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Epidemiology and Risk Factors
| Staging and Prognosis
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Eur J Cancer.
2006 Sep;42(13):2064-80. Epub 2006 Aug 17. doi:10.1016/j.ejca.2006.05.009
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Abstract |
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Childhood central nervous system
tumours – incidence and survival in Europe (1978–1997): Report
from Automated Childhood Cancer Information System project
Rafael Peris-Bonet a,
 ,
 ,
Carmen Martínez-Garcíab, Brigitte Lacourc,
Svetlana Petrovichd, e,
Begoña Giner-Ripolla, Aurora Navajasf
and Eva Steliarova-Foucherg
aNational Childhood Cancer
Registry, Spain (RNTI-SEOP) and Instituto López Piñero (CSIC-Universitat
de València), Faculty of Medicine, Avd. Blasco Ibáñez, 15,
46010-Valencia, Spain. bGranada Cancer Registry, Andalusian
School of Public Health, Granada, Spain. cFrench National
Registry of Childhood Solid Tumours, Faculty of Medicine, Vandoeuvre,
France. dBelorussian Childhood Cancer Subregistry, National
Scientific and Practical Center of Childrens Oncology and Haematology,
Minsk, Belarus. eN.N. Alexandrov Research Institute of
Oncology and Medical Radiology, Minsk, Belarus. fPaediatric
Oncology Unit, Hospital de Cruces, Bilbao, Spain. gDescriptive
Epidemiology Group, International Agency for Research on Cancer, Lyon,
France. -- Corresponding
author: Tel.: + 34 96 3983220.
rafael.peris@uv.es. -- Available online 17 August 2006.
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This paper describes the incidence and
survival of childhood central nervous system (CNS) tumours in Europe
for the period 1978–1997.
A total of 19,531 cases, aged 0–14 years,
from the ACCIS database were analysed by five regions: the British
Isles, East, North, South, and West.
Overall age-standardised incidence rate
(ASR) of CNS tumours in Europe (1988–1997) was 29.9 per
million, with the highest rates in the North.
Astrocytoma (ASR = 11.8),
primitive neuroectodermal tumours (PNET) (ASR = 6.5) and
ependymoma (ASR = 3.4) were the most frequent types.
Incidence increased significantly during
1978–1997, on average by 1.7% per year.
Diagnostic methods may partially explain
incidence rates and trends, although a role of variations in risk
factors cannot be excluded.
Overall 5-year survival was 64% and varied
between 72% in the North and 53% in the East.
PNET had the poorest prognosis (49%) and
astrocytoma the best (75%).
Survival has improved by 29% since late
1970s.
The positive trends were seen in all
regions, although the interregional differences persisted, as a
reflection of the different healthcare systems.
Keywords: Childhood cancer;
Central nervous system tumours; Incidence; Survival; Population-based
cancer registries; Europe; Trends
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Copyright © 2006 Elsevier Ltd All
rights reserved.
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Abstract
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