From: Subject: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing - Nature Structural & Molecular Biology Date: Fri, 28 Apr 2006 09:36:37 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0084_01C66AA7.3ECF6620" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nsmb/journal/vaop/ncurrent/abs/nsmb1088.html;jsessionid=D7512980CC0C3CB87FF10D22A1CA4193 WRN exonuclease structure and molecular mechanism = imply an editing role in DNA end processing - Nature Structural & = Molecular Biology
=20
=
=20 Advanced search=20 =20

=
  Journal=20 home >Adva= nce=20 online publication > A= rticle=20 > Abstract
=20
3D""=20
Journal = home
Adva= nce=20 online publication
Current=20 issue
3D""=20 Archive 3D""=20
3D""=20 Press=20 releases 3D""=20
3D""=20
3D""=20
3D""=20 Supplements 3D""=20
3D""=20
3D""=20 For=20 authors 3D""=20
3D"Online Online=20 submission
3D""=20 Permissions 3D""=20
3D""=20
3D""=20 For=20 referees 3D""=20
3D""=20
Free=20 online issue
3D""=20
3D""=20 About the=20 journal 3D""=20
3D""=20 Contact=20 the journal 3D""=20
3D""=20 Subscribe 3D""=20
3D""=20 Advertising 3D""=20
http://npg.nature= .com/npg/forms/03_current.jsp
3D""=20 naturereprints 3D""=20
3D""=20 About this=20 site 3D""=20
3D""=20
3D""=20 For librarians 3D""=20
 
3D""=20 NPG = Resources 3D""=20
3D""=20
3D""=20 Nature 3D""=20
3D""=20
3D""=20 Nature Cell=20 Biology 3D""=20
3D""=20
3D""=20 Nature Reviews=20 Molecular Cell Biology 3D""=20
3D""=20
3D""=20 The EMBO=20 Journal 3D""=20
3D""=20
3D""=20
3D""=20 NPG = Subject=20 areas
3D""=20
3D""=20 Biotechnology
3D""=20
3D""=20 Cancer
3D""=20
3D""=20 Chemistry
3D""=20
3D""=20 Clinical=20 Medicine
3D""=20
3D""=20 Dentistry
3D""=20
3D""=20 Development
3D""=20
3D""=20 Drug=20 Discovery
3D""=20
3D""=20 Earth=20 Sciences
3D""=20
3D""=20 Evolution & = Ecology
3D""=20
3D""=20 Genetics
3D""=20
3D""=20 Immunology
3D""=20
3D""=20 Materials=20 Science
3D""=20
3D""=20 Medical=20 Research
3D""=20
3D""=20 Microbiology
3D""=20
3D""=20 Molecular = Cell=20 Biology
3D""=20
3D""=20 Neuroscience
3D""=20
3D""=20 Pharmacology
3D""=20
3D""=20 Physics
3D""=20
3D""=20 Browse=20 all = publications
3D""=20
3D""=20
 3D""=20
3D""=20
Article
3D""=20
3D""=20
Published online: = 23 April=20 2006; | doi:10.1038/nsmb1088

WRN exonuclease structure and molecular = mechanism=20 imply an editing role in DNA end processing

J Jefferson P=20 Perry1, 2, Steven M=20 Yannone2, Lauren G Holden1, = Chiharu=20 Hitomi1, Aroumougame = Asaithamby4,=20 Seungil Han2, 3, Priscilla = K=20 Cooper2, David J Chen4 = & John A=20 Tainer1, 2

1  Department of = Molecular=20 Biology and Skaggs Institute for Chemical Biology, The = Scripps=20 Research Institute, La Jolla, California 92037, = USA.

2  Life Sciences = Division,=20 Department of Molecular Biology, Lawrence Berkeley = National=20 Laboratory, Berkeley, California 94720, USA.

3  Pfizer Global = Research=20 and Development, Exploratory Medicinal Sciences (EMS), = MS4039=20 Eastern Point Road, Groton, Connecticut 06340, = USA.

4  Division of = Molecular=20 Radiation Biology, Department of Radiation Oncology,=20 University of Texas Southwestern Medical Center, = Dallas, Texas=20 75390-9187, USA.

Correspondence should=20 be addressed to John A Tainer jat@scripps.edu or Steven M Yannone smyannone@lbl.gov

3D""=20
3D""=20
3D""=20
WRN is unique=20 among the five human RecQ DNA helicases in having a = functional=20 exonuclease domain (WRN-exo) and being defective in = the=20 premature aging and cancer-related disorder Werner = syndrome.=20 Here, we characterize WRN-exo crystal structures, = biochemical=20 activity and participation in DNA end joining. = Metal-ion=20 complex structures, active site mutations and activity = assays=20 reveal a nuclease mechanism mediated by two metal = ions. The=20 DNA end=96binding Ku70/80 complex specifically = stimulates=20 WRN-exo activity, and structure-based mutational = inactivation=20 of WRN-exo alters DNA end joining in human cells. We=20 furthermore establish structural and biochemical = similarities=20 of WRN-exo to DnaQ-family replicative proofreading=20 exonucleases, describing WRN-specific adaptations = consistent=20 with double-stranded DNA specificity and functionally=20 important conformational changes. These results = indicate=20 WRN-exo is a human DnaQ family member and support = DnaQ-like=20 proofreading activities stimulated by Ku70/80, with=20 implications for WRN functions in age-related = pathologies and=20 maintenance of genomic integrity.
3D""=20
3D""=20
3D""=20

MORE = ARTICLES LIKE=20 THIS
These links to content published = by NPG=20 are automatically generated

REVIEWS
THE 3'=965' = EXONUCLEASES
Nature Reviews Molecular Cell = Biology=20 Review (01 May 2002)
RecQ helicases: caretakers of = the=20 genome
Nature = Reviews=20 Cancer Review (01 Mar 2003)
 See all 7 matches = for=20 Reviews

RESEARCH
Distinct roles of two separable = in vitro=20 activities of yeast Mre11 in mitotic and meiotic = recombination
The EMBO=20 Journal Article (02 Nov 1998)
Processing of DNA for = nonhomologous=20 end-joining by cell-free = extract
The EMBO Journal Article (23 = Feb=20 2005)
The premature ageing syndrome = protein,=20 WRN, is a 3'3D"right5' = exonuclease
Nature Genetics = Correspondence (01 Oct=20 1998)
 See all 7 matches = for=20 Research

3D""=20 3D""=20 Top
3D""=20
 3D""=20
3D""=20
3D""=20
3D""=20
Abstract
3D""=20 Previous=20 | Next 3D""
3D""=20
3D""=20 Tabl= e=20 of contents
3D"Full Full=20 text
Download=20 PDF
3D""=20
3D"Send Send to a=20 friend
3D""=20
3D"rights et = al.&contentID=3D10.1038/nsmb1088&publicationDate=3D$date.form= at('MM/dd/yyyy',$rb.getIssueDate(),$system.getLocale(),$system.getTimeZon= e())&Vol=3Daop&Issue=3Dcurrent">Rights=20 and permissions
3D""=20
3D"Save Save=20 this link
3D""=20
3D""=20 3D""=20
3D""=20 Figures & = Tables
3D""=20 Supplementary=20 info
3D""
3D""=20
3D""=20 Export=20 = citation

nature = jobs

More science=20 jobs
3D""=20
3D""=20 3Dnatureproducts=20 3D""=20
3D""=20
3D""=20
3D""=20

Search buyers=20 guide:

 3D""=20
3D""=20
 
3D""=20
3D""=20

ISSN: 1545-9993
EISSN: 1545-9985= 		Journal = home | Adva= nce=20 online publication | Current=20 issue | Archive |=20 Press=20 releases | Supplements=20 | For = authors=20 | Online submission | Permissions | For=20 referees | Free=20 online issue | About = the=20 journal | Contact the=20 journal | Subscribe | Advertising=20 | http://npg.nature= .com/npg/forms/03_current.jsp=20 | naturereprints | About = this=20 site | For librarians
3D""=20
3D""=20
3D""=20
3D""=20 =A92006 = ;Nature=20 Publishing Group | Privacy policy
3D""=20
------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/nsmb_logo.gif R0lGODlhvABKAMQAAFYXe////6uLvdXF3oBRnPTw92Emg5ZurWs0jOri7r+ozXZDlN/T5otgpMq2 1rWZxaB9tQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEA AAAALAAAAAC8AEoAAAX/ICCOZGmeaKqubOu+cCzPdG3feK7vfO//wKBwSCwaj8ikcnk7QJjQqHR0 CAim2GxrwSAABIPA4EoiOAqJQOIwEgTEgrh8ITrIBQgS+ItmAxYKBQyCflqGMxAFAQ0Mb44KIw8B kAAOb3lhbwkDnIpWIg0Cnl4ACGEDCo4DXwEMeQCplIezLAZpjk8AEI55VQltb6SSAYVunyOZXruO DqkBDrsFBiMEwbTXK5myldZhD8ABpMakrMci46CO06ELil0EBBC3ZNj1JcaF5coC0+fW+uDIARTx hgGJZZs4cUpQIJ89e+gCmjDQKJw/ixcFRgTwZtUISxgfijyxcaAIAwIY//7bWHJjRxLJRsq89y9j mwIOUF6yybPnS2Rv6M2U2fJfLBHDJPbkFvIn0oJDhxa1WCVAv4pKy+USUZGcUwDV3jhc4DCqFmcN 9LxJa2xa2HAIIBj79qdqAi8InGE08BVAJit5EKSkY/bQgls5RSBAbAChggTDxC5wNGiAAU+OHmTa tMAYsX4AKDpylIBwYS0HFCo0kFr1AALOHOQBMyAtn1Z+FoB04GUAAwEEDLjmZFsEhEy/QZ9ezlwH AgKvmkunAdvjisOqok/fvuLArQAs2hWgQ0AQ9/Mqnt9iYYkuAEkC0csf4YyFInpu4ks3o0TB1iLG sPCGLGloJ1071hmRyv9/RAS4QhoFiJCKe1G1Bg0EbBygyGvwUBMhIwE88Bw8DZAyIgEHCCQYJw74 YcBucjjACWF34EHCAqvoVhs1tD0Qn4MqOAPGJH/AAw8E+tFyRoqJWBFZAZ2ENkxVb8h1i0cEpOSU G2OI0gp2BcXxwCgixOMIOV42MFpoAxSApDP5AJmCmprYltobBfj4UBX0tCPAAsvQU54jBXgZQB58 iUECnR5JIktVDrxXU0kxEfBdAiBZ1UghX4G0Ql6O5JOoaRA9Q4ICV4QllC1rlQLcCF+FleMboE2m KEs1+WWNAXQuAkADte3yC6yKAgVeChoW4EwCoFVDYanPvPIcWEGVEJP/CbG+8Y0kCYJlI64h6Xro CFgdtAYJX2WC7JcA3OJeIMrZgwBmCpCjqrVvoJDtJ6ekAK5A6hq7gqww5XsCnYS9hRcxQ3ExmmXU miNCwNgWW2a1/aLwb8HHTmzwCaAOyDEKaWwDErMMdCuTd5RFLJS4J9ia4L1hRGjCbJPmSjHMNweC ZLUCm3DvCJfhWYCBD0FHhScpAh10CQRTg7FYJiQgWE0gAfwxzyQkS57TXJehbQm9qvyQABTaChzY YUttMQBVXbGMNKeushFIxRXdcdsIUP0r2Du7TTcJmW5zQHHXuEHqWmFFWso0mZBKLMNgeQIJqwE0 READlnhhzBW8IpQW/4hvmLbeQa2KC4nSgZ9EWT8GSPIdAymKgvQhbjTkT6R9F8QAA7xaLjkso6lh DJQQtFN8ALm8pa3eeN6pCQK2Mr8onmAEUpA01ZdVTuacZP5EZKGeHb4m9GhoPEqcKCDjGCUY4Iyy BlQDDWEht4I4GAnUq5gCv1MAJlo0DQckpBOFmN8VQOSAzrjGcWSriBpERI2TIW4+LjBAvDDIwQ56 8AgIuN0QgtODEP7AhNNhTRheJgQEPCANSaLBASzBwiasMIUMmIcRDiDBGMogATpMgWaGlwIgso05 vathEIbhQxkkSokRM1sKnnieIwqhJDiwomIU8SwBSUw6WgQCFm8Qxv/QEHEFZRSCaRagHzbOII09 GON1TjI8OGoQBnD0gXBW0aTMkaGPX2zM+xRwQbA1RiEQiBcPmbEAYCmELq3hhHs24sJb9C9euyiH QdD1CS0lgB9lKBQJWPM+G3FSKC58pIHycqVExkB9/eufBCHwGAA6ok8FcBMBhgExgphDQ12oXGlO 0ggIUK8rjXGKTiwWEWDmgU6yIIA2RiMQbUmwINNwodMaoAhUueuUVMAN58YmAvF4AUzLs5j61MAy kRnnESNYhkfmFQDThGWTHDmGmgYnKY+EYSuM8uXMtmQNW5nmJwSQIANAxM986g9FnljFX8hgUPqQ M59kqALwLPqJogn/6g2yEU2IoGaq0KiDaI4YZUp1tQ3iUa5aRXMcWTyBgCrYbIsl3Zd10JEKfOYz QbfwQv3iBdIb0VRSvmrXSIkWVF+CThEOuQUC6CQQd5SzqGqJDp5KsNLJlYJttjLIveyykNEgwBIq O+jbogaQLC3ubZkQIUZLMIwnoINOF1wGJaq1DAN9jlIfcwY5LrONvnTVl+Cpin5Sei/BoiBj+lqr 0+RojAS1Dpxi66Q1sCgzpzJFaB2hk1Aagc/eWacK1XybQ7mar8+ZQF00y1XBpCjQzOJHtt6pCIUu S6yX3Qsd1+LkrPi1ExKYVqnMUozfJPSPTbC2W4dd7TK6WDOXict7/+LaYAOmsa/bhiS3zwHc1irm W6qhYxgX/Kl1g0ssSGDnNSB61nGr4RDDjjelthoWCUpm3cqiQEjxs1l3P2KUVrhFvHsjbwmqgjOq uJOT3/jtRS9GOQBqZgxEFKwBKwbd+xqsK8a1xr26R1delY+Ye80caOZirHOmLlAjSwHbwuA4Yzyh aA21VR7u1buG2lQEltjgRNwRyOga2WD5Bc1R/rbUTAFnqqjwGEjRlstXXOlwBsQmJqyxjCcspiMu pENFzvhT0PiiH66F24OJR4bGXUQWrEqLzGrUAKQdTznjBCl5CrdnRv5KEYW60+USiqc6C2d57jn0 aMYzgl5p6y1j6NbVOyjTEIV2RhUHyDD6YCOGabDmFgWwjTF4swBJ0EWahaYDLyEgD92VAjPLa2nR WhoHeNiBLQIoUSjSIhddC8BFx5Ek/mr0KrgNcngz5IQrjQsGGwHCNlmqEZRRgag4ZIjY6VWMZgTR Ih5Ju0wKUIgCTEPs3Fx4AMbsWp5UI0GHSEKuH9xPUkuwmJdhKt4YnJdPS3AuqTUR38vp8kQcsFFy 6Rfg51Ee+MQUBuBxU1lh+DfCT5MXWOPmInmc+HLYCA/lOGyhGg+5yEdO8pKb/OQoT7nKMRgCADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://ad.doubleclick.net/ad/structmolbio.nature.com/article_back;type=af;artid=nsmb1088;date=20060423;pos=top;sz=728x90;fidid=7;posid=10;plaid=157;maact=${dcFieldValue};prisp=75;secsp=${dcFieldValue};proqu=${dcFieldValue};abr=!NN2;tile=1;ord=123456789? R0lGODlh2AJaANUAAD+MZn+ymb/YzO/18g9vP8zMzGZmZpmZmV+ffx95TC+CWd/r5Z/Fss/i2PLy 8j8/P2+ojK/Pv0+VckxMTI+8pdjY2OXl5VlZWYyMjLKysr+/v39/f3JycqWlpZkAAPjv758PD6wv L+vPz/Lf36UfH+W/v79fX9ifn0mFYtvFwnKSecx/f7x1cnwTCd+vr9KPjxMTEjMzM////wBmMwAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAALAAAAADYAloAAAb/QJhw SCwaj8ikcslsOp/QqHRKrVqv2Kx2y+16v+CweEwua2XotHrNbrvf8Lh8Tq/b7/i8fs/v+/+AgYKD hIWGh4iJiot9QoyPkJGSk5SVlpeYmZqbnJuOnaChoqOkpaanqKmqjTCrrq+wsbKztLW2hUIzuru8 vb6/wMHCw7sEC7fIycrLzM3OgbnE0tPU0wzP2Nna29zdoNHV4eLUAd7m5+jp6uts4OPv8LwS7IsN Ag1xAwICA3IL+6kcFCjgwFSFAhVCHUzYZqAFGRYGRlooKGIBZAIJgrKIzF28j+EU9Ev0Dw8/ZApm QIgjQJcAOQFmJOBT4CEiDWkKxIhhk09E/0QGYnAIFdRAGwc7cR6IMSHShRgYBGFgKgmnIQ07C3Za GqMjDJBgqxHAd2gAAgK7JIxkmYBAMl0U4sScMYdBgGt4NDzdOeFAoQ4PhqIpcMDvHgcbHuwUynDQ TsNwdC6OcQGyoccNdybMcCBDHqSTK2uNs7ODoKCC30xdHPiiHsCpCS19EKjC5MlN7xT1GrY3MbyH UhJAcHYGgDUA1yAw3qcB2Tz6nt9pcExNyxkv0eg7mWb5zJJ49MHpsLPyXstoBKYR2FhNxtFoJsRA v8YhHQtPH2xIHOMB/DcSsZGRGrbFYJVrbXBlgAHyQVUfggJqNIcFO3lWkxpcAShhZOUxuP+TUQRu KINkCL73RgU9pVEBQ5jBEdQDCy4GIXtvqCeDfPS9EVF76w0E325vJOcGdzJosOBeFywY1X0JKbZk GxGlaIpHvlWpCwKJRKALWRFIEBcaFKA1AwF4/ZMSAkJ2N4MCaaC1kgxXAqCLSGxQoEt1MiTA3AAS 7JJABGqyiYabMjDgkp6AqmEnXTKYxcubMqQEAAS6jNXGAroAquUMDSwn01pqYOUgGkHlJh8GU10g gwMcLDaBVatuMNmSB5WG0I2jHqDYh/+1kZ9Nknl2204boAHYTg94loauyCqbgWayMtWrDK2CSG1/ aRzbn7IyzMZsDNyeikaBOInaQYPFolH/LURJoaFBg6O+kSEaqzGUAbwbaEVeV7HOmsZTG7xbmooN TvBsDBC20aIFignGqquwnppqrTF0cKu4MpC7alDDWoCYv2golqMMEIhJQDloLKcAA2iB6q5maRys VauqUghuUBjYrGx+F1nAcQwGaKVYujIcnHAlQuyj9NJMN+3001BHHbXLhMxFNcljQkApdjJ4ustx a6T0JqYzAHrdminNgCVyLqFhKKcDoJVAAHJyiobYaJAN6NZiStf1mmjIOffWiX5dskxtbHrMXAQk oOcMKK8hn7UjZpAQaLty4IBifXHMUKkHrIYTvI+B5tlsGDD7pBtGY0iQzwsasKtpUz2A/+pOrtV+ QLQPrfbABA3mKB/R89Z+O8KkIiv7Tg+BZpXM3SKLAcfKiivqQ6Kiqhi3bdCcE+7Rx7ABBg2jIauq MoAuOhrIAr1Yeoo9cMDPUq6hcfJGbc7U/DBjvhMHpJuP89AAvadUJloauIj62mUzWKlBTgSAgKe+ JJxKJWgnakhVGqzXvoqJ6iKyekBCGAa0AzwFREDCVWwu8Ql6bEoB2UlDSyz1NywxwFMBCEAM06AL vChOBovCi+DYMIBMoUFPWJITnfKkNjT0EA0/rFsArnamRtFtJHIqx3W+9Da/ySAmbpEBBK9RRMix 4WDcU4NkLuCaoFxAK8Nb1fy0EhS/8P+vLweICMw6wAHXLIVybZBPbuBwsKHoRITmE9+IwCeDC7Ax ff3BCWjoAxrTrEo+huwPQ2SVLsW8cZHgAqVNppKbUsFRKKuqUPRooz/DYGAClnRDHNHAFYGosmjM a6QiHTDH5PlFMhzoHQZlEEKGtIo2hMzlqpwEyU/iqlhr9CPo8iiZUVLlWROgY8XkGDRfFkmZagAj WbzjxDEBhw1uVENQ0mW68AWTlhgsZvLSZTNhou9g9UNaK+iRsq89p0+QignYFjWkLaFhLv0U1Bd1 0Qa0lONtC2iAEQPHnOuQBaFwUskbdBG5f+RQT3FZ1Eius0OKgs2h2mnbGlrFrwvGQCv/94OktSJS GPlYcl3wbKlAOsC/FdqvRW842Cdb9aQ/Xgt9q0pDi0BztDUuKH4JIeqygMYuAyl1PqtMA5CYiT9Q KpCq+9LKtNZArIEcKyreGwz4gErTA9hUBvtKw1RAxFWZxoErAynAiywQ093UUg04zWpXl4I+B8iH W21967zWQKiDMvQ6iXLD0NQwMK82U52UmQ1DCjQa8MX1mZxoIT8j8LiyldMX8/gb2OrEUJPerYmO ZdQassjElWCUovMgqGslyrU28PYlA6gbL15CTigalLFm1BsarkM1+SCVDYFdLCSH4oCfySg+WFUX VWWwmsmMjIDtOpEntTKs/8kAqCoK/69kesUV79qkvKi83lX9EljM6OxfqPysyOxKB8ncRnPnzS4o VwS+6g4LhJTRqoNIlIb9umhYD1DKMJM3lMBiFzL1xWqBNmDCBG/swNcCpAxImgYwArG1bqhkepEX vpAJGFe7akx7b5MQyeDyAfnUJwB2zOMe+/jHQA6ykIf846slgmWIu86P8YK3NixntY2FSxrktFo1 UEoCWiJAP/pUZY6qtk0afZuRxRwp45ittSlJ7UJlmwbl/nChYSTrdgMZLwtj5oQ4sXEqrYrdqJAy AwVhpBvwKl7KaEUysYud5QQdM2XOpntUGSAoE72g02FLrcjD0bjaJarGYOZ8VcWJg//nsK/CHKAD NikQgjJUQKDleZgAu6ppFtvAOCjGAKaGlZ2xirH0hBdXhrnfwYilFTyDss+sZTOV/6bQzLAYly31 Xq19LZRbQnIClAYRaCrwlO9SgkpWAknkFDGAtSD0OhudwTkfqFEZkO0aJG6UlFm7YzOKkTluu9O9 x/ZESs3EDf6WgZb+vdB/e/mIM1BzGn5oYjRwmc6U0wAGJGntFOITK4NcSm6qSW1AK5PjQWX0BlCd sfiNRs/1YWRPHq1dEasQDbE+dhtSWDv28RmfLQZvDBISa/kudaxpkNUg1SjoOJLymxmnSoAtqeqc f5MncLgvOueMz3Z+D+o2f54yn+L/ozRgfKpNsXo4UfzuMq9t0BOOHlLjKF9MF+CY2vyuyPoD9G9/ Jdy9IbgilnN2Jbpb30DE8nJVygZdrGQBacPHosYJeLbpScv9/PcA9JRaw7s78feu8mwTvlBBNSDN MuAtyhZVUji7FuHjDjrMlolKBicyN4ZFJWHH9RTBLFYyFCvIw5C5IzbYLDVcqUDsEZmGehqLAxQP JSQ9k0JNr2GS9Lq08eGKfBcLpgKTlUye46dd/1xyuwNjecyXUqyD1O+EULrlvhKCGrXTvvWMPJix Cpyf9AQoVIxWPewxadmptlT7I8J9oHQBJAdP6MNt8LdzbABRDvcpGZV6K6V0yaMq/x+zTdKVITZj GJyUHgaAAaNRKi+mCeCGd+9QeocwFwAQAI+THYITAH1iN6E3JwEQWWBmHDLRWp4SQS8IgSn1RINn HCrogDIgJoLTWijlBl72NsQhJg+1C8ShCwqXBg83hPZWRjRYfPGDAfyBY3CVdojmVtICbfuxK4ax LxyQM3FlMx34ALcGc8+WQR/SYQ7CUtgWO+y3Pyz1Of1xRwXhYJJGdCwGgNd2AHlYVSVkchmDLBfA httVMGCogAyGU1yhhZqBFN4nZyPzIpS4TQHmFwczhpjxWdzlYTYDI7sCIlNBH9IFiLgmSAUhivMn FDlTIA+wiG0IbYvRTZ/IH1i1iv/aITd0Y1C/BQf8lwYstYgNchEWlla8A0ocVj5yxRehMIIkGA5n xwiHowsAEEPB5SfS4TWlNxd/smxlJgFb025IiDhqgGRXYm66MI7MoVyXolJpAwC8tTfmJCaQsgZ6 cng++GZsUAHWtQE2AWpqkAG7Ij6jsRcGcD8OsBddYZCrMQEF8BRRoRMuR0sJaTDYNSwc6CqNYWAf MkK31HZqsC89QSwfyRcMISr3wpIKBjQF4heTxDETYC/D1Gvd9SrRQx+CKCA/w5NV5RoMqTFCh19E czAPcCw0yYa9kk6sk5D5kkjPtSoQmTwy+WnzYQEZEC3pUpTtIisZ2QClZY/5NgP/RrZnlqEB8VMY ORkvoFVVgoGQi7E64ZNGInh31QgPkCcJA+BFeXMPlyIAeLIGEdUGXqYPafl3psUG9kA1h+kHhMkS i+kHK1IHB9ErF+IGmdkGl7kGQcEjEVJ3vncrpZljf9B7/jcuookiccBXdkAjy5RNeiCbAIKaUSci 0RNLeNCZc+CbGSMlz/JcU5Eam3kH/1CYfGAjf9B1a2CQ36CXezkO66YM8QYHERABksJPmKATRNMM KTQJS4GXo7A5Q4cJ5PEAriEwDoQNFqABhDaN0jmd1dBszCBS+bALS8Sd/FkIddWfqCCSrEGeztBd BJoJQpBDCrqgDNqgDvqgEBqh/zkEmMnwDya4BgPAABRwoQDaoXtgHx6aChXAUwdwNNlQAQegAbiJ CaIVoi76ojAaozI6Cy06ozZ6oziaozqKCDW6oz76o0AapD/ao0JapEZ6pEiaDtRIn0zapE76pFAa pVI6pVRapVZ6pViapVraC0u6pV76pWAapmI6pmRapmZ6pmg6DV2apmzapm76pnAap3I6p3T6Dmta p3iap3q6p3zap376p7twp4A6qIRaqIZ6qIiaqNIgqIraqI76qJAaqZJapYw6qZZ6qZiaqZqKqZW6 qZ76qaAaqqKapkTqDGczqqiaqqq6qm1aqs5QWqwaq7I6q7T6pK7aDG9Tq7q6q/+82qvhcKvMEDe+ OqzEWqy7CqzM4DXGuqzM2qyaiqzLQDbOOq3UWq2HCq3L8ILWuq3c2q1yiq3W6a3iOq7kKqbgapgC sKARQKGjIFyomgA8JiZgEUERsA9zUa7CwGNpE6b6qp885hsEwGOwiq9meq7uBgGTQiQCQAHEwaGd kKuoGkPy+hEIACqnSrC9EGcQS4ITWw2rtSiyxVvv0LFqpqyW2rGZCq4LgADbCAcLQDcOuwkDa6Yn o6DnyKTVIa0fEYWFQqcSGoQywaAm+zUMKlwI4KAIKwzDEQH94FEoCwyrdbPhJgEMcLHUcHaeQnAb Ow3Dka69EDn7OqlUa7Wcuk//c0ABf0IHiAcBlYkJW1um6+akcUa244AnWzOzbRpn6cZ5aqCzxeAy 2pqWC6Ct8nA1jkIMKfhRHFsdIBsOX3JvfLtmHjsShKs2CnqpxgAmoAqtCKAAyikHndu2l4C3Yqp5 Zcakq3Wv8aBQbwunprsGIguBvwCBj6N3bhC2M/C4AIelqzW00xBDuxA57joNkUO6mNq7m2u2cBC6 ecC8o9C6YZodeFK52rhjaSMBAVAcvaAA/7omAQABMxs5XNa9vACvO2a84vsLAZtDEIC7c9K9BIC9 xjsnEJBDEoCyAXu+73i01Du7aYCwP7av2fEcuNuX1VFGkcsAPIYAeAKxkDIA/0GoADQ4v2tCvvkL ALXLv8CQANjbuf77Wr4Qv+zrviG7CxK7vfXrgk+bHQj8NdbrCxycQwiAt9xbb9r4vRTMCyKcvT+m J+YLAEQYjJWCvd9LwjUsXCkIvr4AtskLun2ZBwCwn6GQw1nadyXmCx/LtmlwuLuQBg0AAIXZuI3J RGvhCweMtzsWQywrXARAAS4jALh7wJAzEsIgAcrJxZaXMglwTpsiDJFFwSPxuMPLRTIUvFPGCwp1 Nqu1AAMbWWJsxj2IjjPMx71gltaxrzsWWQJbKdUpABPLurswEjprxxjqNflbHV+8Y3KzcOV7hYXS saKsNnjSjcNAJnGwHMChAP+kfG+2jBywnDeyvMVIDACarL/PqryJ01t6EDf7CArQu6WZO2Ky1ce7 8MBtUFoKdTXKKsfK3Atnp7p+km40RET7OrfAIbK+oLtrQLjA4cZs0L+8gCfDQHAQcFHl2x1XTHgd mwa5SsBY7MVKW8g+CERUo63XqAaTh29t4G9Ghs5nd7esPG9tsINvAHqxtSYNLa8ElyZogM7qy65K kxLPcY2N09D3vFylx1uviwZSa6muGjcHnQeGErOjW6bCC4MerW5q0CUS8By5eo2dQsxtVgwCLcjx /Iu/sNIz5NM71lFfwwb/0LpqRlrGMRLo7Dca6o7CINDBoGYte2K7gBd2IYX/oQzM8qAmCQwMapCv +QyD/OzOsdWXn1fV+dbM7EYWjtLLMqCtRh25czHVegIAVj1RiGlvkLtEEJzJ/JwWhqlDay0MLOwp akFRXYyh9wCDeQ0c2hqFL7tDedwGw+vSyLwGAfDEfJAAds0Jz4ylCTBShOcLI03UZp27i70Lz/E4 qfvZRvu/UHsXMmS/tN1PYZ0GaTNucDwMgkfNkcMLOy0m38zWmisMkXMyPwg4jaLXtRvR7WhchE26 jw0M6YtiAufc+Xx28ooAETDDQAgcdpFDY0IBxxC2bQ28Bwe5yc0Ly225MaSgnnLCmB223GzYfLIL 8hwMCuWuX9LHVTa4xQDf/6eLYvcaOQPeeDfM3pe7qa46HNtAxVSqyfWNu1z92iJuyJQd3lFL4LMN DJDiNRvdC2o2F5EFzrXMC4/71NytjYccDKmtBgIMzPymUjGB14wNB40L0GrNQ8Hwxzh+4wotRWkw v5BCwhMbZ/dq5MrcsRNb47uQKC2sC7EMW5Ir0XUTQ2GbHXRb372Q4NW8cE875fNN3MNV3ehIwmX7 BlrCrodQAZyhopCw2lW6WmcDKYSb23F+WiFu2HWTyxYUW1g7DIou0ZVL6AXOtdi7odwR6Gj92fNb nWvAC669WksurFzNg3kz6GnwyHNy6L0Q4Cv+KE9+JVsMtL4AHMCgAPVbr//PUTcE18cBPsQBYOmu jeLSfNICd1xUiN85/uVl3bPBcHb7ukReAxyhTb8zKJiUjZYpju3MPtCiWqpnASDlZRR1SW3zMWPl wRACuhN2mQh0fqX+vORhLui9IOTWDda78LiYd1ra/mZnbttIflxdHrmeouobzOlnqdMg7IMBP+8y 1DQgS+XqWGb2/LEm3PD7sBZeU7LAcHbQO7fDnfAIj8Cm7W5DSxZWy8Bv8DgvvujDLhMGv+0Qf9aO FWfULNE+rN0R39I6PBIDQAG+3dGFnlHe/LmvHvHUTM+8YPLdPtrEzbNXdxvi/iEv8xjmLo2xxxTL A5eJ0O9UyvE6HOLAMbD/At3oQV/ZLd9bLdF3xBDiqn7TFE8M+7kAdgEc5/gcDH/2v0DwvLBaLzhl ayOsZK/tLUwAMfQ4N/0LwOG78H6vdp/0cu65jjmxp94L55SuARDgh0/ocT/3vA3vlev2bV3x5bTy Qw65wSDYbeDJzA30lG8dORTgpA+FOY5iqJ6yTO9EpN5/lPU+o0j1ExZ8pZYee7GigjDtVTry8+jv 8rb3+YzvvSDQbz9vLVEdXK/QIEvojl9OrV7LVr3b137ok3/64R8MxXtcaCLczh/xF6tmW3P4GbsW T1vf2gr+0S0PDAAq53jiJP5F8goEC5lMMDMKhjKCMZCUzAiDYQNgnCGS/1VmUmE9JpfNodZKSBZn Yhk5Dfa+rWrZgsGeKZKMtzqwNAqJ4rK81PxmAJIg4BYZGx0fISMlJ99gYJIwh2YYMjELYmIKOkEf QmUMYi5iDg5AkzpALVAnPEEzOnFzdXUbKH1/rSh2Mb3O3jiHumaQNL2whhRnIJIQCIcEEIcSIKeH qo2yZQLeEvKMkGWUHbsHtoPdDpMovMK/GbtlohsjhgasmPnN+ZfEioQk4+gdNILvCRw1ehqhcxdu npV6jAigQyNtkBUpMioaMTMk5McFVgLK2MbOnRFhQwylhAPoZJsxb57J+MZMiRdmNR29NLQopz4j H0NCkTcQps8hQDneBP82lWpVq14s6Vqm6xMor6ZAcVglI8YEVKxAGTBQKsYGsjEwZAJ1YFhdu5js XdVbrp8Av38FAFoDTqGVBCatGPPSIIk7dOriEQkI8dFjK3hIvuGphXGzRwE3GukMFF9eNZDhoLMz 85ogvIlbbxnS8N1swkMoX8bUclFnfwupWUtm2OgMxTNeyvCCeXDB4DP4yohgBdBv0G9GL45dJsn0 qDJoQ/k4wA/iYkO8N4oeIfyb5GyYszHozePTN929JNe7n3//Spdy2SqXrr4Ca5UYOPhkg7NaKTCV t+jCZK67KByGPP+q4ikv13QC7ik/COiswzswUQcdykQk56l+eGuEpzf/xjPkRNgCgeQnPxQQMT3L UCLIkRQdGUkcK/ARyAjmQuIJMnwuPIqL5T7K55HjeDRCpjs6UyccfXgyZEsO0zFiviGViu3GI3U8 T4ZeEhoCIeY2CvG59ZYrTL1MBohgQwGVa1NK2YaDDj/d3HSqKQwRTZSSrALkqZOuOihA0gIceOuT B1rpgEFQJm0wg1LcknCsCknFBSFFJwmHTTjCQSg5GQagIADBNhoTtwB4atK47WgsNJLjAF0ggABE bMAPiiJJTtiUfJ0BSOp4XQQTwADT4qLbbBPzuRmiBCyTvJikAAAJ0JEht0WQFc1HaGucoToIAKAg xh6fCqAOIc2lQDDP/9SwtjBlA2CWTCevCTgMJ5giIgB9zdG22Ss6agSAfZNYILwkVhUJEwYYJsbh gSGWysqK7V0N1ZMTZRQXBeTIpCtR5Apllhgq2DQGUQ8Q64FKh8gAFA1KDTqTFlFmRDCTSTQzj06M 5bDcftRBEo5ch2pEas1yadrDER8J54ycyABWyHPfYE4XZU4zDNh+jYhOl+I22QVuOEqjMbSxLYoS kwEgy+lJR2FFoLONUvKDIWy/jjjuvUfWxjCKGwaUjeSI9gKZBiCIQO/mmCMb8AEE347t2lRyphPU ik6dP5U7QcBvl0GJdFJROMXAq1NWaXDSDWzxORULZNCglAeELj5a1f+9wCc0OCo2wpgAomRgqBcl oLXvRFLDPpKc9kxj3wY2rPIRBExSRI2JlnIOGkdex4XePmlk48WPM1lAAAgql4biARjI/5gnIwMS L4zJKApg1gIoQDQ5/IYAPInANiJXHStUiXxPMV9jvEAAZnlHghlkgN4iYIcuaQdWjhBDeg6REu8U BQ4N7A4EcZOwofjGIYxD3g33w7pMSI8rDnIFpzSQFtyhxUEXqBTvHAQ04xWvPTicytUOAYCqcWsK lwGA/4xmn/4oAABS7A8AUOdEMS4HAQGQANJQxkVIdLFqCfDifsAoCQJ0kRJdRCNVouA47KBnEm6c ol7YOEZB/kKHmdD/YC5qphZFquUUBqiALAxwCwxEMgOLVMsGeCaDA7AlFUpcotAW8MdBQoJ7j4gO 2SihhiaOkpWtdOUrYTmVcFSNAIDoXixxOcZCYiIAKDjBJ0tlAZgB03hJySUckhPGAWqPEiEiFrCO GU1pTpOaiIoOFdoWujVVk5tF22USUtACD5SAmOU0Z12Uecz5mVBxknid1roZT3nOc55F6oQARElP ffrim0N4gQc8QIIPGG8BmzvnQTGRMWpizEbwoERyBtCHfU6UohUdJAAElqdbWpSji+jnEEIA0BAM NGgDAIBBEZrSU3UUjulk6UthGlNKuPGNMrWpET4qgxGAQKQkrZBJ/0WUUqGy6KZFNepRkZpUpUoi pzIQAU8DSk4KLQAAQR3qUJe3VK1ulatd9Woum+pUqHrABCOwCwMkgNKrpnRuX3XrW+EaV7nyE0B1 EUFIAcqCYdThaWu9Kt/mGljBDpawXQ1rElbAUxUggAIC+EgDBEAB1/XVr2tVaGExm1nNitGOkLHj FQ0D2rbZ0RBu9IJp7/BG0NKUjo5ALWtRo4AuyHa0d+iCH49khwR4lrdviCMcDpuED7hgCgwY1nEd W1nlZmKlm3Xuc6Hbn4T6gZdWYAxl5PCNJljjCxAZkhwckdY+Qc8vxvTLMtCw3fOWQw9RyE1gFmCs EBW0vQ2gL5EAC//cui6Xv+e8Y3QBHGAB32ccCuCf85qLhw/6Ybtx20aDt3AEKXThu/A7QnPJxw8m ZPUIRThvG9C7hQRAz0uhNAMEyDdHlaQYEdsw8C2D218Z2yWUA7bxjW1MJnk5rw6i1Vc5tNunE4NY EB22n3HG0QQ7HqlFu20weSXqEw+nVzkfjoLmmnsknUQADfngsvMU4dgAVC7GMzazLlCIYzWvubBk anB1uTWPBngHwhXmLnqxgIgke6wRDZbAnw8s5RCD+MMQg0oZIDtocXxYHArmB9HKfGZJZ6KtbLb0 pblKJgbUBGQGgawQDta2DkGYyOddAD/2LAlSp+E3/5hyhAuN5Bb/NqBpDOgyAmztvDIqZ8j/mfSv g+ZSTA+b2DI1FwCagJBjx3HTx5WSkiXQgAspOY4NPu989kzaO1SuwXraxKqWMGdpXEgA0xEAFUAL MijQ2g8sXjF5WowFApSjiZEG9qRrXGx97zumJOsVPgdGa5tIB23P69OHkbDnQQggy0Qmn2Np85Iq yAlWXeDJONQthz7Y98DzDTR8OWzve0uaw/w2+cn5jdoyiDa3V1EAb16+nPyJfORnbjjKcZ5znQuS 5jU380Z3HnShD311+/X50TuRX6IvnelNp6sloB51qU+d6lW3+tWxnnWtb53rXff618EedrGPnexl N/vZ0Z52ta+dDO1td/vb4R53uZs9CAA7 ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/common/images/clear.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/images/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/nsmb_icon_onlinesub.gif R0lGODlhFgANAKIHAOvd9P7//4OKn1JnedzM5srA1qWou////yH5BAEAAAcALAAAAAAWAA0AAANa eLoKTmTIOQpg7ZEigw/AcFyLownTFxjGOG4GOmyD+oluBkCFYASUVcsFKMQkBY7Ng8uZeD5gqlfa HQW0JZDk1MSkHWpJBxkAljMG6WmgUAQYLmZON9nv+HsCADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_bio.gif R0lGODlhCQAJAIAAAJmZMwAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_can.gif R0lGODlhCQAJAIAAAACZmQAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_chem.gif R0lGODlhCQAJAIAAAMxmAAAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_cli.gif R0lGODlhCQAJAIAAAJmZzAAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_den.gif R0lGODlhCQAJAIAAADNmZgAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_dev.gif R0lGODlhCQAJAIAAAJkzMwAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_dru.gif R0lGODlhCQAJAIAAAP+ZMwAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_ear.gif R0lGODlhCQAJAIAAAJlmAAAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_evo.gif R0lGODlhCQAJAIAAAGaZMwAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_gen.gif R0lGODlhCQAJAIAAAMwAMwAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_imm.gif R0lGODlhCQAJAIAAAJlmmQAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_mat.gif R0lGODlhCQAJAIAAAGaZzAAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_med.gif R0lGODlhCQAJAIAAAMyZAAAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_mic.gif R0lGODlhCQAJAIAAAGYAMwAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_mol.gif R0lGODlhCQAJAIAAAAAzmQAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_neu.gif R0lGODlhCQAJAIAAAACZZgAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_pha.gif R0lGODlhCQAJAIAAAMxmmQAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/areas_phy.gif R0lGODlhCQAJAIAAAMzM/wAAACH5BAAAAAAALAAAAAAJAAkAAAIIhI+py+0PTwEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/arrow_red.gif R0lGODlhAwAFAIABAMwzAP///yH5BAEAAAEALAAAAAADAAUAAAIFRAKWi1cAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nsmb/images/spacer_purple.gif R0lGODlhAQABAIAAAOre8gAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/rl_images/arrow_red.gif R0lGODlhAwAFAIABAMwzAP///yH5BAEAAAEALAAAAAADAAUAAAIFRAKWi1cAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/__chars/arrow/black/med/base/glyph.gif R0lGODlhDgAJAIAAAP///wAAACH5BAEAAAAALAAAAAAOAAkAAAIShI+pFrvtEgSh2lvjmZE7rx0F ADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nsmb/images/arrow_black_up.gif R0lGODlhBQADAIAAAAAAAP///yH5BAAAAAAALAAAAAAFAAMAAAIFTGAHuF0AOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nsmb/images/arrow_black_prev.gif R0lGODlhAwAFAIABAAAAAAAAACH5BAEAAAEALAAAAAADAAUAAAIGTHCgqAYFADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nsmb/images/arrow_black.gif R0lGODlhAwAFAIABAAAAAP///yH5BAEAAAEALAAAAAADAAUAAAIFRAKWi1cAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/ni/images/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nsmb/images/fulltext_icon.gif R0lGODlhCwANALMAAAAAAP////Xq+1YXe/f7/tLZ3vv7++rq6uPj4729vampqf///wAAAAAAAAAA AAAAACH5BAEAAAsALAAAAAALAA0AAAQ0cMg5jrmDaDLEKNjGCR6YbVRyZJI4KMgpcjBL0fGsvTnF 1jqcjwI7JBTIpEJlOCCeUIQlAgA7 ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nsmb/images/icon_pdf.gif R0lGODlhDgAOAKIAAPf39/NiZKysrtefo9nc3OkfHtT29uvN5SH5BAAAAAAALAAAAAAOAA4AAANO CKoR+y3KtsK4194imBCGARQHMHAEEAhEmh0nq7KpExVF3RrN4OKdgIFAWZxQwkYL0BJwgkzCsEWI 1Q5Y2OBjVeG+YJTiQy5/HtT0UpEAADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nsmb/images/icon_email.gif R0lGODlhDQAKALMAAAAAAP///1YXe/v7++rq6uPj4729vampqf///wAAAAAAAAAAAAAAAAAAAAAA AAAAACH5BAEAAAgALAAAAAANAAoAAAQtUMhJBQky6I2FIQLGicJRhKKGlucWopgJp6o8cmylm4Rx /EDgZ0AoGI9GwiUCADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/common/images/icons/fff/permissions.gif R0lGODlhDgAPALMPAP///wAAAMo3Jvf6/fj4+Onp6eLi4qmpqdvb27m5uerq6vj7/tTU1JSUlLCw sP///yH5BAEAAA8ALAAAAAAOAA8AAAReMMgZCnkYh7HACEqAXNnmfUo4lp5HJQUrAfR3GCywDIDg CwxSADAR0GiC1WYwMPZ8vdFQYnQiYcue9ii4UZy/3q3AOJitvQaMUDC4GT9Bw7HKPAiIhDlRt9/b BhYYEQA7 ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/common/images/icons/fff/connotea.gif R0lGODlhDgAMALMPAOkfHuLi4vj4+AAAAPHx8cXFxXd2dunp6c3NzdTU1LCwsP///9vb2729vamp qf///yH5BAEAAA8ALAAAAAAOAAwAAARb8IF5hCT2aQkUIg8BBACmdcD3CGR6aAeCjMIydYEmEETA EAsCQtF4bQzIZIJROQYQhWjBEMgMroMCIxDADiqEhMFRAAbHigTmkPBeC41Ec/WUFhDVje7A5c4f EQA7 ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/images/arrow_black.gif R0lGODlhAwAFAIABAAAAAP///yH5BAEAAAEALAAAAAADAAUAQAIGRGIIaxsFADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/prdct_img/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/prdct_img/logo.gif R0lGODlhWAAQAPcAAP///wAAAP/7+/39/fHx8f7+/vSQkQEBAerq6vWZmZqamlNTU0FBQfz8/PT0 9PX19X19ffeysuo1Nvadn11dXfvS0u1NTO5VVXt7exYWFs7Ozo+Pj//+/szMzNPT03Nzc8nJyegl Ju9kZpaWlnd3d/7x8YmJifr6+mlpafvV1uo+PgQEBKurqwICAvrMzebm5vatrf74+FtbW5SUlCIi IvWWlm5ubklJSfzh4qKiov7r7PzY2b+/v/ixsXBwcAYGBv/8/Hl5edTU1Hx8fPzn5j09Pfn5+ekx MetFRhAQEGZmZqWlpfalpUNDQ97e3lFRUf729mNjY8XFxQoKCoaGhpeXl/nAwJCSkkZGRvj4+F5e XhkZGe3t7etCQvapqmBgYCkpKU1NTR0dHe/v7+Li4uozNfb29vagoPFvcOPj4/3n6PvIyPWTlP7w 8FZWVt3d3fLy8g4ODucREe7u7vrFx/7z88/Pz6mpqektLv76+u1TU/OGhtfX17Ozs6CgoJmZmfBq aVRUVBEREXh4eP719fBmZugpKutERf3v7zk5ORoaGuzs7PvP0IODg+o3OCwsLPiztTExMf/2+E9P T1hYWPi5u/m9vWtra729vYSEhOcbG7CwsOHh4fDw8PF6evJ9fQgICO5aW/rGxvrBwfrNzv7x8v70 9Le3t+kpKekqKvOKi/SPjzs7O+ksLNDQ0NHR0e1GReotLeghIo2NjfBcW/BjY+xDRf/5+u1QT/3o 6fSMjPBubvvU1PONjfzc3c/Q0PrDxP/+/fJ2d7q6uucYFxMTE+cfIK2trfanqOovMP3k5fe3uCQk JOYTFOYXF+9naPm2uNPW1tjY2O5YV//7/PWam/BxcsHBwe5LS/m7vP719uckJv/6+u9iZO9lYvOB gv/9/vKDhO1QUWhoaOjo6Pzf4PWhofm1tfWio/ajox8fH+geHvnExfjCwvrOzu1ISe1JSuxKSvet rf709f/09PF1dPF1duvr6/B2d7S0tPOIiP7s7f7u7m1tbfetrvv7+yH5BAAAAAAALAAAAABYABAA AAj/AAEIHEiwoMGDCBMqLHjCQw4HCyNKnEix4kAEjwLMscixo8eFGwIQ+EiyZMcqB8iZVMghxkAB kPJUhFJwgMECBXHWnHGAk8ICNgEsMkGwAUFtTNR8wuVFIB02CbwRgYIGVS999eQBYKfKAD0AvryY 05MCB5tKq9QA8PDFx4YiUdLw+eIHgg0AxxaEGTISgBQtC2hM4bTkEgsHQ1A0EqiAUpNMUiKtQGHi QaNAT0AAUNYNjxdkoYyVq3ABRy5n6HDEk9DOSohCAHSE09SGV5kunkLY0+MOwCp44K4EYJUDRYAb GAIswOLmjyIWmKZgacCDxp8OTVYgGBEgyIkqARhk//FxQ4OfR5vEJDFxZ0MGIYOCAIixp1WJ2NuW WYkAoMS2agB48o5ASOwiUCV41GGKBBcAUIo4R0ygywWOcBNNACQIlEgAd4AyAwCutKCFQP0EsEkR MjAWAAJCBIABAEYk8cQSAXQg0EhFqCMQCi0oAMALAiXQBTUA1JEMDALpwAQx6QCABjYABKOCNQJB UgYhACAhwnwhAIIIPyWYAsAvAXywYwAjTDECACx0p+IHgkAgEE8IaOAiAGMkscAHAQA5UCJiPABA B1sEIIOfNRwigINH9ADAGdWMogmSgOACABCO4FOlBC4dsuU8hkxTkB0YCkTBD5j8sOYpASghEHdU xP9BiUAocWGnnA4IEsgQAfQx0AOAGjEAGWnwOSIANaggkCSxWMKLsi7IEUEehcACgAASPHOpAXjc AkAXW3IQSjOMCLSDAK8E8AWexcjgQQBUDMAFGFvcA0AYUziBxQo8dJKcBx0EEAYBGqzQRB8BgAEC H1Rcw8AK0rwQRRYA/HADAOWIkMoohMgjiyrQoLKHP7ZYwEg1cgiTwgTr0MLEJ4ZYssYRSJDCQQoW pFLLN9lw4MoKcYzjAwRkzPKEDcMA8IZeJExyCgBCMKCIDRTQkIkGFGQQhQnM3MADC5FkwEAOJ4yw BQMKDEIBBG68AsAOoriwxj7AMEKHMhGcIQA/VghicMsZPbh0Tg1t+FJBCS64QMoai4IjDxs7CGTH AUqQwYVAJwDQAMUCdbJIQQRk4YADRgHgwAMFjPEPTg0QYMRAZsAh0BwIrFRRuhnarvvuA0nRalC8 B0/SAxvIYEM+OgkfUUAAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://ad.doubleclick.net/ad/structmolbio.nature.com/article_back;type=;artid=nsmb1088;date=20060423;pos=right;abr=!NN2;sz=120x600;ord=07893195? R0lGODlheABYAuYAANPo9HmEpqusr8bM3CwySTIyMzRDa42PkYp0MfzDFtTY5QEVUpylwayMKUlU bldYWuPl7R0oTGNyniQ3ZlVllbPa7Pv8/fG8GOi3GWRlaOLw+NeqHfvilUZZizlMg3dnNv/JFPnV aHF/p9fY2o2ZufHy9lpTPUFCQ3V3eQEVTebp8Kuyyq+JF8XGx7e5vUpLTJeguaSsxbe/0mdbOsDF 1va/F5Wcu2lqbvL4/FlfbcyiHhgrXf3uwfjKQAANVAxTjr6ZJE1OTwN0sPL1+M7Q105JQICBhH+M sFJNP//PEpydoL+WF0VFR3Bxdf723zBto//VD4GIqBU9gEZFQuu/F5x/J3ahxwAMRi2FugNjnaTT 6FBQUoiTsmBulW15nVpmhv778Wxyf21XGFNTVREiUlaArZPA2eCwGvfDIxscaT0/QkdISgodUvXI FF1eYIhrGN3f5jo6PUlHQaOhw21ucJGQuHFxcMHh7/j4+ru60u/w8llIGOzu8io/ewUaUP///yH5 BAAAAAAALAAAAAB4AFgCAAf/gH6Cg4SFhoeIiYqLjI2Oj35/kpOUlZaXmJmam5ydnp2Cn6KjpKWm oJGnqqusrZKhrrGys5ewtLe4q7a5vL2ovsDBtanCxcC7f0RHXszNzs/NEjSSd0N/FjHZRCUkKzBw 2Ct5MSQxKzQkfDTjECsMfxBHcMaeuzQeffn6+/z8739aNEgiIWOAiD8i2nn5Q4IBBBUiFKigEQBi CTh8YryzIEEFvV+TuvQb2e9HFjOSAkpiAAPGij8BFLj7AyPGtZjJjuBhIO3PCi5wiEjg85HTLnz6 JihVmnRpnx9CoqIEKJDmCiIB+BwhIQIPTZt4cCrzOkDCgBUkICgYWnTTrg77/8ppjHFkghcZK8Rh iSrkZMqq3fh4gRMADgkSDN/h8aLgz4AAEGzmyQvjD56ObTW9zTehg7VJJHbYlGRhb1+/VK9lk6GA jw0FeEjAyfvHdeMBDhmYG4L3jwrZmTNt7jOBQpQuFNLBZdDhCZa9WaKjVjnJgiXrpC/hwR4cpCS4 TXfQkDHBw08zVk5n+fFjNPXux4j9AZ+UwuIdHQAAoLaefR/3AlkAhwIDlDCEAuAMqMc1KlhXggJE EOGVWtYdWIIkDZI2AA3z/KEAa5YhiJ0FH3b4Bxw0DMAHibB5SEOLeHjkm0SWDJdUDHwQ5wEWWWDh kRX+/ffXTV0c0QUcFHDxB/9zEJxIgUcqdLBMVyv0MQ0JHjRZAgVE/DFEAFzIkBADR8jgRQx4dCGC dXhwEaYELzHgxQAwkGABMxYwIIIMAUwjQxfWDOCBDDXKR5+OkU3Qh3Q/WOGTFPoAKMkREfWhQHJ/ xEDBgjJ4AFYHMuTh2QBS4iFCB0QJitgKHVwIhwwd3OYBHF4cIUmnC7JK6jQWNCnCERB4MAA888DQ x7AKCFsoJYdOcBAFE5jEnhSOcgFpPpL+cURydlLQxQpeUFCCHitsawEeHYggAaEDcEGBDMypgEcM NrRKQhdeZdpBkyoMWqskMHRgXbJcdDDPWRAdIaiJcMTgxUHJDluJjfkMAEH/H1Jk8cQTP5TxIFLY DqktBU3Oh5imQwxQjgfTSEnBSzLQoKagD3YzqAyWWkaDlR56oMC/2Pj8Bw0d3JPHHzhDEACwQlow hDtYQgBHB11y9wfF5kWR8Q9PwMBaDB4oGumQFogA6B8ldKBkwArIZgEFIvQbQ6cKxDCADTHcowAM A5T9pAQd2LBCCdvGIAIDad5lA2FdOPySu2iJUAKeWHbTbowekECEBwzMNAnFxEU7bR/4MLWPpCxa 82CCCqjl1YAqiIggHCoMgYdaalkDwQC2yyADUcnk0RgeChDYmAUDyGDih7AR3yIRK0DAx/DFq2U8 JViTzjHppOPjAchCpgZf/3zM7rNtGUd04MERHogQgAQigJ/tNdxZYPV21WV3jf7jLzsJfcVJH5aS IwE3SakLYgufSixABLzMYzwrGJYFIDgABTCADyuYW8zckRcZkCBXJoKPjaTQAcCJgAIUSFcXJCAB 5JxuSCWADBxeBQM88CEm6LjdChRwkHIQT0VlmqEXaFCCFXxmfKAjCUlQFwOzIKQxPnFTl66hAFu1 ZAAd4oLEeDi4/r3CUEoMY8hSY52yiEliMuBCACTmISvyrWRanAQX/uHFo4gxjP9QCQYd4xLJtYkG KxjKECCAFYbYBAILOsI0ADaaOsqHUiKIpCQnSUlKLrIaXpILBPJUDhmci/8BXIhe20qgERrEoAQW 4BtpzGE1EcpnFhYoQb7QdkRaksZ+5xpR/VrpSi/60ju/DKb/hEnMz70yFhbQgAa4MwQcUMJ+xoBm JmIpCmQgswIVGNEdljkJDeynEslsJS9x4MzrgJMSytTEELZ5DRwckZdXO2YsvKkfDdxBCwC4wzaT qZ9rVKOe9sznNreZz88AoAL11CcA7OnNO+jHoTgAwBDo+Qcc6HOg+sFmQ5Xp0ICy05i50ABCAWAG ewYEmwStAA4sUAF8WlQLWsAmAAKiAZh+s6b6iWkF7lCBEqBUnzVtaQW8mU2R7jSmMTWqSg96VGzu FHvydEVDL7pTjWrBAjP/JSdKHzpSezpUpgKZKkB56tCF8jSgFfjDQcm5UKLqU6YKTShCsQnVXpCz ohXiZzsl4cy74nUSK7UADkpQlYqWcxJDqN9hSbNYvtrviLWs6F9BWszKWrOyvrwsZvun2c320rPB 7CxoMyPa0RaltKalB2pTW4zVsjYYrn2tL2IrW17Qtra4uC1uaaHb3cqit751BXCDy4rhElcVxj2u KZKrXFIwt7nVjCp0b/Hc6QLTurmoLnY1I93tCre73i0ueMOL3KjK4AgSIAEUM+GOkl2ivauQwLFO gRsG2Ne+L1nSffH7icsygB9svIR8A1yJAZNiLYhhiATWS4r/8kMCkugH/4TrIU98kKAsfThIJgyM CQ6LYgB9mDArdjeAEougD//oAwVKXGIGu+WYIO6DJGIsCQicOMMlMzA38LFiSciXJ31IMAnMIoJh yYAC+TjChY7Qhw68Y8iNCSQDsCSBCxEuHxHpMSbgUrIQw+NC0bUEjdFWYkkgGYUq9vF8SdBk+Wbp D/J1Mj4a4+ZjXSzEy/nDPuA8XweTAMnvYHIHkBxiF09CAU2eRJPBE6v+wjgflkA0BcycMwPj40Js foeBM83ndxRRAu/AGYT/22MD/xcx/30HPpoEFzBfgs0J1nOImZNoCosZ0pUAsZNpPSwD58O+P+bz sFIt7ErEw8sgnrCpUf+8JGbj2sOWgAuhVvKPEqza1rnGdQnKHON99Hq+/dB0n5ntYQjINx8QTraa h81sYnP5D0h2byUQ7YENz/e6jsE1jUG8YhZfyNfHYnGTli3uLX4vgsj2crGJzfAmI1nElvivhuFh sUlAm7uWuHOTqtSBfE8YvgCfMQO+ze6CT6oP7Eq4ssf9DmLPBx8JyQSS89tsW6Ht0tguMOnO/Q8L s9kD/57viQ+Hj28XWdrF5nOZHp5vzi283cxmc0EMPYk7u/rOR6A1xF98iUvpQ3IzRop51g0PQgdZ zVVKc9JxRjomQ3hLkCZ4s5+8j7FHXO2TgJU+quzoTOzO1ZMoMeDnXfH/Smzb71QvMycYwLkpk24U BBq8Uca72Yt1IIKkJp9vgaxiYGmevLylPOidK/rRh9n0vy19Maq4YPY6ZBQQ2O96Y3/fAMdeAkeg OWV9SWgCs5DsH37wjPnR6GSZb2KqF0Y+JP/se38ixrjJx0ugf+QMayvEJWA7g63JE0KZ+yA2xnLJ eIhuKLLwUmhjMrMjfeOINBvF8k67Q34s3wTvWMUEzreMO63/4cu4/pKwAtO2e5NQJYiBM7ZyZmf2 HSrGdLKGD83WAXlWCXCBZh3nbZRwbsfiZoyXM2xWQqQjb/1nfMMyZjhTbw5GR8iXcWn2XzukdkhW PLiHNriWDwoQdAUi/wK65yEwaCnQB3iIdiwlIF+EYml9gGnrF3j+4H9Thg+2AndNln+XhWRD2Ae7 02T2BRdsVAIOFmH7F4H553Fkh2uV0HwkJ2vAloT+BzgqdiHdlmRgxoVIsYOXJXWJ9oYVgzZspg9e OAlViH3ZtnLDQoaUYIbFFm7Ztn8ACH1haG75IG+XBWInhhj8xmIFAncMUAI1+IUzBhc2p4SCKGuX YIgAZ4kiOGb/lW6EWGMyUDIT+EWYgBQp93EOYYB9KIor8YSrqG6HyImKpojzFXKOMXKJqGa2Mmbl 8w+AVleXcGNg5nOkw4X4d2O3eH0iwGaTVgnQWG+4WIZB5ohnOHQdSP9gMcaG84WMk+BnNwaJUZV5 YZcPYxcs+bCH1QiFQlMJKyB2+bWKJ7eBwThfEGB2saaEXycx6JiO+gAqK3gJLhd4BeKHYRhpD4kJ iscJkacJBCKCq1BBw2AJK4Bkb4Z6p0cJpDaAIplzJ6kLyZeSmKBdIumSqAeTpieTo0eToGeT5IWT 4aWT3sWT2+WT2AWU1iWU00WU0GWUzYWUyqWUx8WUxOWUwQWVviWVu0WVuGWVtYWVsqWVr8WVrOWV qQWWpiWWo0WWoGWWHyEjI3mSDSMBBjAB8IRxqLc3XzABhRBC+DZdeNAuX7ADidBIKNlcJUADUdAB fskIWzd5zaUCLhD/AB5ABpDgBwYwCmgJe+BiAGwQmYTABmqZl6BlQQikmYmwg1xnWkRgA3Upmoyw EH2HWXhAAwVzmKpZCAtwCJPZmsHEBzIQBQ4gm7MpCLVZm4lABgsSmN2hAisQP5n5m4SwAM5JAGTA BmRAAEhAAIdgkqUZHG1pAMzZnM7pB84pnQgwBSbwASaAADPABsI5CFGAm/SwN6HZncDpnLXJBhEQ AWowA0XwAVUwAyZwAmRwAmqwnITgAO7pC8hDAqkpn+ApnPhJBhFwAuU5A1WAAEUQB3EAneA5nJEl HCtJCkNAA+njm8z5nRDqB2pAABSKAAjwAUVQBASQopnpAz6wnutZ/wgROUyzoJuOCZkMSp/B6Qcn 8AEzMAMfcKT+SQBsoJ40eqOMoCSeaQoKgZkMaggLgJ9I8AHjiQAmEAczMAXRuQA16qSP0HFR+glw wABdwJ1VeghscJ4m0ABFagIpCpmQ+Z3MuQNxuZCkQAQwsKBtmggLYKQEoKSQ2aTAWaVTlJ2csJex +aM16ggLIJ1AGqiFUBmKqQnZx5skOptiSqNkQAZiiqeKQKqWWghfkJfI2aMMSqM1Sp382QANAAQI EAds4AOnqpoT4B0N4wVU2p2fWqP4SaFAsAFnUANtAAVJ0AYY8AGmmquOwAZ4OQxqapfy+Z0+wAYE IKEf0AAbgAE60P+fahABSNAAIAACCZAAckCm0MoIKtiSkAqq1okEQOCtVAACUHAGauAHrvqpVZAA NQAFVSCquRqpj9AFk+eprqqtctCtCCCkLfoBF5AAINAAz+oDEQAEIJAEOkAAuPqjeJqh7IoIt8ld qnml3IoAQHAGOsClfnCrNNoACZAEQOCxtLkAH3CuGxABH3uyQHqfEQCmEtqzjCCtL9YIproAUyCr G9AGSQAFNXACNEoIPvABM7sBU0C0wIkESZAAG0CgkACkEBoBMBoBBBABFhoBJrAAPpqoI0uayIcI wfqyUysIPqCiJlAEGgsC+qq1C3ACFwACF2ACWsuvVpsEVTCyclv/o6FKAPtZBFOgpVMQAV6KAEMq B9b5neoJoWTKmh7anK5KBnFQnizKpeo5CK46A+eKAYRLm2SwARSLAE4qplWQBBdAAIo7n8JJnQTw AYWqBi0aBwKKAHIwAxEgB3EQAUv6qvhpAoVKpiULr8GqrefprRiwscqKAQNLtAsQBxObAAhQuD4g s1DQABEQpGI6BW0AAjNQuPOJqxEQqjNwApOLAA2gBtPJn/s5nffZoAvwuycAnWpwnuzKmZqBsXEw BcR6BhsABP2JBAhwBudaA+HbnGygAzPbAARLtR8QsDoQB7japEVwBlTQvt75nWaLBGTwAfs6Aw2A BD5gAlVgAnQ6/wXJq7xsa5+4K7wEIKtse7YIALaEALefo7JAgAE10LXG268+EAdnQLEYcL6DQLsJ AAU1q7U+MAUXkAQYAMO9WwU6cAFAUATv+8NxUARy4LwzoAZEugBqMMNIMK5qMKDheZ8Z+gFIQLi1 6gP2iwRyIAdsMK6IEACaoaUIcL0JcAanO8V8XAMggAFq0LNiOgMzewZZS5sRsAHn+gFZ7MDEy6+M m8ImML8Nm8f6CbzTaQJmSwaRmplkMLlFMAN/OwMqbKRxkKIEYKuJegjcCK80WgWOnABT4KQx7ME8 25zeCwI1YMK0Sb4anK3Ki6uFOqQDzMLO67j5ScMLUATd67HPGf8HC4AAjku4BOC8o/ufZwuduPqs hkAGkmdM/GoCGNC1nHyjPnACGey3FzyzVbDIqNvBUNCxNRqpwEvLLUoACEAG6DwDyRud/Mq/coAE ODsDK1ye/0mucRyqETCfkICdUMWvBLABXVsFfosAUIu7tOkD/2rFNku1RbDFZ1AERBsBM3yeHyAH CICfyvuyS+oHysvGJpClRGoCaczGt2ydocrRmtme8AqebNAAXasDy/mpBMDAcmCwjEzJSbABUovJ mtwGnFwIRJrGQCsIGj2dAMqlBFCh5XykRG2d53u67ByZBtrUhuvIt9vKSLABG0DR0onV4KkGeM3M zQkEVTywNpr/og0aqtq6n2s8yn5wpFNQ0yew0Um9obmbCFeQAoawAx36RXaLBGeQBMvMBkMKBMuq A0CgA2dQBTBso687sw9LzAhQxR/MvX5QqI4Lnb07Aw17AsSby1NwAtJJsHPNCClwBcotmRPA2Thq 13erA6RtrODaAEc6q0mwsW0gy1O8AOQLBMdMtSaQxKxLtGyABBFApERqnx8QoIA8Bfj7sv4rmsmt 3GxgAF1gAzRwQ37g3IMApYUCnGQA1TUwuBsNnNn6ARhQxRiwrgh+uBsQybRJAIgcvt95pe0bAUYa yeRqnzuN2fSt3FdABh7gBSMHAbIUgGRwBYVgpgFutwjgyBjg/814WqO1fa6yK5xK68gl7L4YDALg feEaXgRqcAJFENc+Sp8hrtw74AAiEANEUDuzNAlwMAEsTgg7MOXwbLfyTNowbAg+oAYSnABAgKdX +sQgILveqdIbCwJV0K3OercZytO7rJkifgWdEQA7xAe2owl44AD+PQhUVwhNrANQAL7uywYamwBS 3d3OHN7ASQConQAXsAENIM5ue9yMIOIpMAFfECZwoAeJxQnQJAL9fanDMMURANVkzq7jW8UNsMhi ergCPQhToAMbEK7O26DMWd8sbgCfTgMQkC/S5HcooiKZsuKomuqoe+NnIMWgWwUbS9jgWQQU27eD sJ/W2aRKrv+Zvk4GBiABfJMhXgIHAzAZCtBKMUIEA1AHdUAvc9AYCrADVz4Iu/riXD7PNfDlVJvJ AQ3twBkBC54AJ2CjlTqbTF7iDEAExRki524DczAHNvAaknAR6G4DdTAHdfAaGOEVQ+AB9T4I0wrm aiDSiG6jVcvF/N7dhp0E3AysC5sC36IAnyEgwjM0dRAFeUMECKICQYEXUSACXiAOHPLOXnDqhACY oK3q0t3qzgmqH9AGCUDtCI4AXCzhovmpV7qfQGACVxAD1gEHcxAAcEEtNm8xeqACMZAHdXAEcxAF k/EiWm4JMKDshJCYh+Dd6XoBG22fSwsCG3DVrm4CAa3ph9D/r9Rpv9+axFVwBQsRhH2QBh4gBU9Q AoMZA3WQB3MAJxOPIJ9tTgNA74UQvUvf7BTr5t26AZUuzmQKpB8ABVSf9wtbziq7+KdPsVItYytw BX0QBRRgBU9gKRrg7hk/B3nwELijCTjAByrQTyVgACH/sp0ZT4SOAOcquBvQn7hbt4Vwn4HMsm1r paFbuSt7AY58rgBbA+pP6Uo6PWmQBiIgBWXQBWmwAjgABxCA/O2QB3kACANwf4SFeHx8AIoajIQS fpCRfiuFhJKQC0UXQB9FEQs+C6KXkT4mQGcgGGoLl6A+PmQnM1U6Zxc1ILoJNb01vLgJICZXMngd Ph5SHn1p/1EWfHkrcytEeUQQfxbaQ3wQACoqQxolhXAxAROkfiKVf+sRn6GireulSCBQOic+mLA+ EeR8aKADwwVhu3z5SpDgwpmCuhBcCfAngI8+zNIkwwGB2gAFJYYQwqGB5KKShPCMYNDFAJsrV1Ks 8+DOHj176wB+mMHm3wICSAZuwPBLFwheCw+CcKhjSZU3LDboAuKH5gofabJiDMAHmkhuKhQBGIID B6EhRGB8UQczhVuZ68jwqYSz7rpXoQiYQNBgaNGjCxeC2MBiCYs3iKEuKfgLAwEyQxT06eDFRh4F c//g0bCoBLltf/jQ4LI2Rdu3diHJoJsaJ142ehGgCpZQYf8vDA03OK0iRkyVKixYMEYqDMkVGn+I YHb3x7MKlH9UyIjSYYfpt25bS4rCWrs/WGTU0Jqdq7ZChg0xVHGKWMwb4GeIAj6fRCJ35szhrAjg gcxp1N5d4kB3duEVwQkf1HILQvMx1AtSGBD2xhIX/PbbYSwIg5RtvoAARAod4KeNAgx44dJ/cAVo D2SF1PXKAgENVJBS5j14xi8PBXfYe0vUgMGNG5xxC4dEJoBBBDuUc1ZaLfmBooraIWcJKaD8FFRf RDHIi4MPNnTGe8FdiNgGG+jQ5S8bEokmQ0kYt8JopT0JZYBctEgKGbL5hRBxu/zIyxJO9dbberYY xNAFuKj/aRt6DB11BhBqpGBdTNjNaWmIU17Chg5G8XmbDjpsgNgSGLzRG2LCEfWLokWit8sGDXxw wif1AGjprTuAllMDDgrj4y0XGGaYGHu8cYawNx6VJqtrIlSDDlXMoAYZVd5067WXDJCpJD7M4Oux 0P5WA7jARaXUsswyqssF0M4QBxv0WIvtvJKQsG0kC6hxAQg1bCAGC+tVESQGhs7HbJeuqgIEAiYQ 4Mc88tIrcSRf3IsJGRsw9KVwINx4MIeMavgoAkjIE289E6csyQTb2OMDr7wsuOrHze5yRqxymByx ytfaSooC7+T0AZc018wvrB9MW+0oPM8LIBs7TGAAGSlC/wJD0FROse/H6i7V7rtLo9z0raixQUbU BjiQAx1hTHDFJRXbFEHGaoa8LhBVNPzwyWP3XPbZUqudgRtjvLDGAx68vbIFkJBBJa/nqWvkwnpD zHTfc1ZqNtqCP7AFEyecwMQaQbiRQ9WQwAGJB6T4MLSyjSZwMwKehC025gFqzrkDbrjxQBChi77G C0FsYbwbX1B9SQyQBNA6EjUkcRTSU+h8Oe4q/r2775/HwcQWvgexhvHFjzHGFg/c4PYlj/iRB5UR ANGAtNRajn3mkMgEeNo5+P6CGgUoQBzWkAEjHEAJRsjAA9Ywhgc00HwPyIABFBcJA0BCBWxwmf3u l73s+P9BJoHr3wP+F0ABxkENaljDAeCgBxXwQQUuOAD6HuBA82UgBxSERAb98AcL3uV2HLSL5gDn gAmk4AsZAF4cAhiHE6LwBGo4wQH0wBw9HOABvqthBr7ABtRB4g9eCCLZtMe/DGQABQ5YgAEecEIo ovCNoVNhZpgzAhRkkYYZCIN11vGHFYgxdx6EWgjN6DnQjSEHULvBFJgAOigGL3RGgIMFJskcPCiB hjR0QwaaMEE+QmCHf7SH9kLYu8K5UXhBuMEO/BCGLQTBcIxs5AkP0IIRqAAPzLGAC+6oySZ0IIeR IIQ6QimJUfKvd1s4QRNPCLpYroEJ6ltA/85nuGeCrgD/arjBAQQwgiHg4ZsqGEELBHAAOgShgb2z wxc+SApCdIGYxlSb/6YwBtJB8QWNDB4jTyBBNdLBga9cwzOVmUJtCsAFAlBCQs1oBBQY4XfotIMe vUgIBnDQg37Y3AQcIM8FAnCZahjDGVHwT3wONJYPQOQOUEBDV8KSCWo4YQb+qcAT0EEACqSDEQRw gxeg8wZh6OQlCKG6vmkOEjsQnAL/t0QBnmB4MI3DFlBwgAMkkHjWfOYLVMkGOwJUoIxc4gma8AA1 nJEOTRCAABzqAhdkwKdYdMMNHABMHgpTZU/j3AQnwNKogvSJLwhsYLegTSUo4QA3cOkzn6m+Iypw Cy+F/2IcTnADOijQCEZIKxEUSgQX3GB8DYzgOttJiNFiK54ifIAFd5CDMYxOsk1EoRNPAD6dHlSt CKTDFgT6An4aYAEOSOwr86nMEzwAs1U9AAoEgIcWEEGcTQjCORuYxz1KohAwGKNMNHrMEQIwgNNi A+8GKtsTOnGyW91pC1rQVoQewA3Dw+cDHOCHCUQXlqGL4gnOF8FawgGz7B2BOFFgvtDmUajBJIQC AJkd7nZ0Dd9lYhNPYB0PZIC8MZ0tE14gVyMowQXrXW9b12o4wwUhBztgQxgC+sj9KlANbhAAHOCA AiY8gJudzUBosThTug6VEBZYZV10t4O08W6EU2iqCf+XKcACnMBtBkgi6N442dC94IwHFIBziUAE 9qpVhvGF5gQW8IXCWTO/hHUDP3cqgIYKAAJw6Gwme6dJdaKuEh0QZYM51z83vICZf25yE0vYZAFG irUP2Ocbo8jhJnhYrSEWMUKV4OfAMqGfvAvsQENn4zGcwA1NOKBVD+rcXdJZkxmQqHW/WAgu2EOQ ZSRckuMwhgO4oMsJ7Smhd31CMojXDa9dNAOxrFZSRxqhbQ6s+NxA3wnQQdMn3XBMsXhAzH54ve89 tRklimC7EmIA6xBvDgb3OyUXwA0uEDAc8DAEF7qADrsmdBys44AMBDumarDxDRytUBCvl8tdbqsR BOv/0xyQgQwrfuVLNa2GV6LAsFVVApcfGkEzmpEOaMxhJYYg5EikQLwQZqYyvfcAWs54xhDQAxXh 0AR5l1ANUJayGxmNTg9fe8stOOxhK63paJZZ4fEV7Bqg6IadugAOQ4BDm29QcYvfAAVfqJo7WFdM PxgAwo504xZCLYDnnhwRVBzBGuItQAJIqrWPjOIYsmjYg/o7524IQhPgS/BL/5Z30lU2ZIn3ADpM 9gEPdy8tjaDtbYdBeawuRBTWMYEgwPGNWw38v0eAcj1YwAhKHvQJzda/WHJak0U3bL/bikA36LSe dWe2Gm+Qd2Ur+wY5H4P3XoC+JrQADzwtPNvWl3hC/8hgHTv4c77zzQRar93DbXWugCnPhxa4QcIv pzewN82E3h3wsFkGcZu3idMNC/2QZ1uxYPPueDew0IDJVUILqOiCJljc6ShIXIILUQJQRoINOUg0 TENXgMIV3e0g9lwCBgEQcAMllHkxh19R5EBUdX2jl1C2VkcnoGmCpUqsNAavJF0a2H8u8AeGRQgl gAcQ0ALJkQH7hlZN0AQO9QUUxBw+5HHAxXpxwGG9ZUjZR04P5196gAJkFwdmNwE6FksNdwNZ5IC3 hYO2pAQCxVuvdAO/lX8aqIFMEEB0MAJEYATZoA0tcAAlwAc3cFb7hgJU5QVd1HuEEEak0HjM9D2e 5v89LFVASgBAbqB+I4AHB2BuTKQGnNdT1vRwKmiEbodAVRVD4sNbrpQBaRRlxKOBa9BUcYCFRjAC 2uCBkXR5biCGdIBxDmUEvMccfkQKwWdeBxhAJxBAKpRoBdR1I6AEeGho9MZSQQBTEkdO6adQuJVr u7WEw2M8KQU1dBBfApVhy4RALgAalOYCECAAdHCJKaiCmCV/3lYIKkAKKUAGIdeKBQA8TEBV1rZl rBhv3gNlsNiITMBNMWRAondYNvdZo6OL50RYq/RZYLVME0ZbaqAEX7FLtJRzL4BxmeiMLGiGhPCC +cMGBjByjkiKNzAGanB0hyWAcNACZOdkbjMBORD/izBVAExwAOKEQBCHWZi1jLHESFq1W9HUWoo2 WaADSzDWgX9QRxmgBBHZQCjQjI4WBmWIH++Uhn8WWzElQICXAQWgBKtoewNoBBO5eUm1BfpViieA AgImiFZlVZY1dKLTSKMTi6pnAG4wBS9FOg3EBA/kBiRYAgdwRiPABwO3byroUCiwA2+DH8wDikFA j0ymBg6VjUbgAmKYbgIwkU61Sg7ARlEURSdElqsIktuEAsXVYu0olirVUy5Fkp/2AhUHakTwBwLg QAcAAS5wPmEohkbQSfhRVJdgjUwGXk2UiQGEAuNkQHCgBD0oQEwAZWX1RIUZB0HATWu1b0xXfLj5 /0jtmAEp1kpbYD5KhE0+JVdMZwREIABuQFhdhwKHU5NimHHRWAgWMEweZ5AEtUT02HcaaUDkRJRE 8Hy8tkRTUJEPMAWL9kYF8AJEyZcMSY9wJJz8NGb5d5w0VJe6eTwWtwUZQE4maARbmGgY15ajJSI7 6XH1BZzguUxbgFhxQFWltn52AI7quVoOIHzvqUxM4Jzth0349p5NCWO/ZQBMdzy/Az6eE0FfiEWO hlZ0YFg3oAYPkIIYp0fZiV3AN4UJyUQGNAY7JYBEoAdKMIXyFlNe6WsOIHsz50QZ9gA7N2Xl9aFq sAUOwAb2VUhr50o1hEU3MKa903ckZUDUeWmZmP+JFiQiCmB/jTN2jqhkawBqRRpnLRCRdvST3uNI W2Cb+VVe9BhA/jNzJvpGTIBibMB69UlDfJdJlRWjEdSWmAVfckcHdkAH9CUi23kJH5dhJcpEAbQF j9ZeEEAEZ3Rq5vM5Y7BX8JVfdjmoJvpXcBQHGTBmX3CcU/hpwPY9vWOCX0g46VOT7sd02dQEmLpO IvIHppU/D3pCompCpKhJBkSCOGVOIgVZxwk+9MVadUllsWqXgnqocaBawJVEstd/OrZEBGRGY8p0 WJQ+C9k7/WcH9hoGPVoINvCjhfaThmloY/BwXfFeGbBbWAQ8gTUGDuCkW2Cf4fqwPrlourmlE9D/ la6kkS0FXnJFB5WVRUHQn/VUAGvANjnQpiJCBMA3di9HiggLOlS6biwXQQ6ESfvkU3DpAWUFUhD7 sO85YShGBjfKQDF1Tr8jWemTiUToOQlbT2pAABPgODKxrEHmqWzwk+k5Wb2zBpGYHA+0dmXFtA33 AIC6s2TbszHlBvqJkE52nNIFWTM4U5lIbgYwATvgaw6ar4WQZ8UEG9jIRBBGqi6gByNQOkTrZ8mE XqolKQ4wa2QbriU6qOY6mChUQqQjUNv6PU0wVwZQt8V0Z8vqaqBYij0IYQVglG3ltbwYi/hmmUHA BuL1AkvWuH+ls4MWBM12X464YR9rOpubYqLg/zOkJSLgFroTiaOjcwC3hKSWGZ27+EpNZJlbQG9b ELsPS707ewI/e1+9NVnSNbcp5gcLQCn6s2rBix8l4DjFFB49yE+eY2t6gHvnFj4T6EDFdzhBAGWy t7PyJrvnhqtYlAMOQAA74Ltv4boG4AFp8wVe8Es4sayEQHXdSQAR9nLGhQKkGoklIJuDwz2GQ02s +4MPUIrhWmj7G6sHaKsGkAIGMLe+tkPVOMArTAZeMMNfUEQdx0cOvHhpKLovd0Jau5E7VQJukE0K 1LXnJF3RSQBm4wByQL2AKWGZF0XPRABT80G1kiIG4AVd4ABc5AET4Lpd5EXX5cC/R7y85loZoP8G 6OcC/4NWOoZOMztDcUAtDhAEsfvES7pPTlu3cEqNO9ABvZtRlWIXDhwa6Otx6nvC1ReWblBVLRcH KriimEQ46OMG83YFBtCwqfnEVda0dGu3zqod2SHGDVzIBPlBsAHFf1dPpFNV01u6JOU5Bca8IiUH P5iug0Z2+tW0A+y6+UPKOAHMqVHIYLQOBsCD0mp8KolxontG7kc4GOioAroFDkMGTEzCJpRfAmy3 CwC8HETMn1hME/CcCElrbDR0ESS6OZq5OvZKXes70+IHDoAE2exG2+y62PFxiPdHxIxBnpoCNIAH RHCbODrEUGQ833VlZLqqlfyrUwCXa8RIe2z/t6NcZEWmwAwcSsT8B9yZP1cQBXigAijQcBz2iykU PKa4sedDyXi0b7cqKZ8MSh8Hw1zaAZQByDcsRhvdoJFwBV/AByPgZ54Dan8GU1EUQArdU5bpQJp0 AwD8tOwUyh9EBl/gAelABt4r1d6BGsJMyMQ8l+IsYBtWOKnkePf0XQS0jEwNwFkNRNS4FlDzy11N CpTiB742t32sHRttmg5KAwJwT6NjrPkWaE5mgmwN1VecGpLyQXP9zzpEt0XWAVEQAMljKRvN0Z56 BQxwhzNoOEQIXkPng2rAwp2bPYDETq47ARNAGVFQw178vXNy2c36QT7Ng9wbBCY4ZQRwz6OM/zuj nAKqvdpf0AEiMLe9m0EYBSWXva9pOAYmREMc9clyDco8cx0ehNUGIAEzTNmqjb7erNwbjbJ3orp7 DC9cPQEI3AULnNza5QdFdnAG0AUK7AUO4MVSYx3sPS+XjQc5LRO97MJ2jTZRM98d0NGZExMZRQaq rcDz/QVzC9VugeBNc9l/oLfrgFET0AVd0AFr8d5QCyX5zKU74AFcLAI1bNxCZt3YQ+GgmxpJtbl2 zdj5PWSoDDiqHQBdQNk4XYbfzTM3QeE0sNUy3kGMbdcOYAAdEAAksNoxXeT3wzcZROH8PTYI7hbY 3RJJ/uBfHMYz7uPxYtcEMAOygbciQl9NA//ZBqDAAYDjkI3cPa4yfBMetKAD+yI9ZI4fOpwyH8fh WtwBXgzKXe7lN3EgCWIm0oMevXDnzFHGel5fqv29b54yJ7MAbBAjfZEAh040vqDo7nC+RhXpEgPl QMEXqZDp6KIQnD51xBTqX04GsQEEGAACpk4zqV4JzrPqlhLncTAesT7rRZPoFE4I4YzrrcE3ESAe tVDnsPPrHFLr0pjXxI4vXx4BUyAUmL7szK4ozl4Ip0zsk17pRWDtvp7tzLLtZxjtoo4EslHqh07u zG7ufURMcf7qvb4LDvEQtpAo7l7uwU4In8RBuj7nyo4e9w4owbEEG6Dv+04kPYAA8I7ZfWP/7AhS C9GT6bnwI7ZgGKGS76qy8L6ABj3AATwABkHT7+4E5ydT6dV+6RZ/AQRTJsHxHj9iEDUQDKf+62gQ AiJP8qxh8n9gUfOS7gNxBteO6L6AAWFiGPHhMTOz8Dkv8g4skHt9K6K+F6gg69hOJKECLGji8TXQ AzrvBJct9Rtt4AXS6mEuG/Vu9KxCHJpO7mDPAWLf72RPzLP9Qzch58meBHz/9l7/MSHPA3Pv8yXv 89mF96NA6H0RPUZR8/HR9H+vJiC/84TPHHVfyOINvilv6Rlj6kbSFADzBrgR+Rzy9CNf+ct6+Q7M 3zcBG+reAKW+C+gRIUECMIXBGKT/9WGP//obrfoO3AGubvVrfyjxAfNPQSozkvtxP/i83/sPTwgu AAQD//aHsR6L8SMI4/FgL/jN7/O+v6w8kPWLcv2I0vVOH/g83/2E//0iAgZocDC4wfbkbvrpr/6o z/4i0gO5TySmDwgWf4OEhYaHiImKi35+i49/HDWTlJWWl5iUPSEcTpCfoKGHjaKHPJmoqZudpa2u jI6vf2CptZObPJ6yu7x/pLs9tpZoPRw8YL3JvL+yIcJonMfK08uxsqeZ0MbU3L3Mr7SVq7rd5bvf rz245ObtsuiuyO7z1fT294jw+Pvt+vz/1PwBHFiPoEFlAg8qBJVwoUNFDR9KLBRx4sSKFv8f+ltx RAIDCNMk9BmgaAADkhnzWSt0pI/LPh4UKCMhQWYiBn0YpFR5CIJLGSVEiriHU+dOQ/AGuCzxB8LH QRJIrOjgYcUgCCJcigD5R0HWPiJs0pRZ4oiHPh1kDCp6FOnKQSXOUuBKCGZUmIMo9KGgl8KgDnv1 doA68k/LDiI9MGXblpC+FS9JMB3kMu9IBXstK8Ds949emSJJSpDAVC9Jxo19vSU0QOTeyZX/hFba gQEDwAOUShikYADT0IWmFkbdOCGDs0co9yGc++XL5rsNAf9z/Dn1nKkH6Rug9g9kD8qZK6WQO3cJ 3bx9yy7ccitw4m3hfWcqA++f2LP7RF//8RH9etEj+dTZe9hlB08JgFFQXXL35VRfH0ydRQIJMEXY x4T25eeBDDgNV2Bq+iigl0tHwNZHSxcOMsBZMFnlHYtVMeeZSxKYdp1RIK5GCATq1bUcBDax1qOQ JU2WHU+hxHbkPBiFtySTOj5pUJNS2kNllVBi6dCVoEyn5SdcfjLWlwxFSSY+IX5VE1QSDEBBjLK1 +aaLY0EgAYMMSKDWbWgZtYIEK5CgkwwJ2uQVjTaNJqIMHg0iggR0maNPgnpF5xIFFILXIKYZFgZY aX1AUJ8HEpy1J0w5xaVfhX9Qqp9yZwn4Rwlo0QOPAnfOGttSDSrHFH7s9QFUrVmpVd9Q/zgNdd6r DJAAZK60LtegAkx9qhSD7ghUQodO7iotsCRBRkJ9yYl0BAMt7caYqpIZsq23hFDIYR8uZqtjCRS+ 1O23/MpIq0fCruecuh+ucBac+Drn5B/10RSqrauVoBcD0e5r8X+WifRbTuXJRFzCoUqcKrx1ldpZ loaIezHJ4A6S74CFOWUVYwqM+weFDKjc686OukSClavhRN5XK/eL8R9KFSg0AxPfeBVMTAsr9ABE 83xdwBD3xGK+RTvppUso/fGVfosV/FJyEGxNsoq8Zn3IefPwGCQi5wUJ9yNKDQX0mYTg+tM9YaZE G45u8w1Q4IZ7Y2bi9jL+jz5epsSYbf+LUJ7yU6/oM+ZRf7qoJCKfy5j54kuGbojpkZei+ZpluWRU 6wXi+rPsKurlQbuGHKqfx23OKoGyZqHVXedO6r5mg1PBOR2ftZWJCIEdAKYTTtFjhx56aesH2M+G uLqbyuQahlZiZRsVm/fK3aUpcKOWivUjkBcWWgkiWDV//Ui/ih5OP9Oqad/QqoysKGQ/0szoNAWq DK6SU7Gd2Qg4xWIYWMCkI+iFjXphux6z9GMb08GFW62CkF4iJRwEmk9aHyQZcFZ4InS9ChLxI0lQ aMSUGZItf7vZn3NMB7LYUGg8hKgO2Jy2sx4ajYUAGhgFn1cYFQEGWwN4Ig6niJMjlCf/bHCZWAPr IxLutcdOHjrhrLSoQvmZ8SS5mRtEKjgcBlYGXbpajgYJZhTLEUJnsYlWwGSFMcZUBo9HNCOASCKz JR4COO2hkF8SmRnauOlVmPEAA7ISnSDuhWpKcg3bNtQhE4ZnalVz3YM2hkAFNQ2GbJThiGIyRpew cka3e2GH0KLG7F1ISTip5IhqFMbw2JJr97mTz0Q3NgOi8hO9MVJXhoQ0uuUmEXeDBDMXEc2eqLEQ cgsF4hw3Om7uY5veVB3pwjkNcJLTeedEWTr7oSP+uKiQa3kUxQbBH65wCCUKyFk44/cw/7jGleUj THTgkzh+6gQ9mKEXobDDReVISyTd/+EmPxWjw4G+yifgSWgfZHIWZTIufmc5yQYtGp1YQQYwK/DJ YPbJRgp1oKJreWGxWlLF8LGUiVE80UhjatGo3UdBH5JoKiFDo+uQlG0i2U1Sm+jNGP6BRQQ7ahyx ky8UNjWVV/tercSHLcAEjKjRMU9TBmATsVbJqarajao6MKKwoYgpCeXeEHOpHCwuyak3e6EMWBRU 6vmoO3N94RDPOk5E9GadhkRsOcyp2EQwtrGjKCxkxTlZbjy2stqRLGYTu9mCdNazn32HZkPr2NGS NrKnFW1qu7naVlwWs6+tbGwnO1vI1raxt1VsbhG723X2Np2/PWdwyTncm7aWsscVRf9xr5pc5Zr2 uMsVanO1+dzWRtdx1/1odfHhn4xkNxS0S8l3DQfO0USxAzW7IXUAI0l6tomSTPkTJg0YXvPOaRAL 7QB/Krm3XVwqKx4QQdO+4z4EdoAETaMegq0n2L1kqik0OsuBv7ldH+XPL2yhCUlw5rSGsqWh/uHV G0/knRRRmBeV0SHhWoMdtqh4iiHul4tfiKYKh+fFSPNqixlMRxg3ODyQSY5Na4xiOW5QJ5AhD1tm 3OM5WiytZ7Fr4bBJVrg8U0U9SvGRQxhQJjvNyTuLjcH69Dgd0TV/KByslnvsujFPby8yyMrPhBbn FMXYlwE264kPceak+Qgla3Zavjr/kJU3S4C9IMkloqcY5h/xVb2AszEyI/XlybjYo4oQ0bmiRrgp EyWoRAxFS6woA71EtL/7gA9BH+EV9gKKH+PlW6zPNGsy1fpLj+2ubiUNQO7hltefhVybopdeY/Kp vV2JCm++EhY2iaigOvovTASMHQJHmdGuWqkrrWrraBsZw1TtHYcRmpkZycQl1II26IzcY9aI5KD6 eyFwPIhrb1OxQDl1nY+jM29u09reL06ySXjM6H5jF+Bb/tSX483vwtBbS/oINFvaHFJGS+jBVpM1 wns86EIzeswtWhh5q6sASuv6ysQF9pixtetkHKdEtAV2Z28NcZlvluZYapIdJVLP/1Ks+hF2bNLD DZI6SBCvFEoSur8XUnRzJL2CUqGK54Ql9WUjytl+oQmjqmIw9Fp9d19vdleYnajClEUu3fHb7Vbk nVczzHYwfzuJTOSYaJMK45fCOPoadJb1xNIDFMiK3vae7b8EZquIHJ9LQJIgVzvNJ9ojMeQPnUAU RlxaNhLxchYYR+Wku9/L2g3nK8YZzZTe3BjraF4ZgJnB8HHJKfJf2wf148yuW0ZrmxUIM+lwdhfi Xb5fZuhlZPAb3dlpjEF5U9K1sMvj3mhGXJjB/RN9XRdckDsrikp1tVLYd7op/7SU5e2NMXiJjGJr m/6rzl8x/yTTn9iPDVtEQgHpxf/0zUZ5pgI8UJXjq+b25dcvgCR9vTdFAwh/0EF8Bfh4MHE7lrZj YtQSauF/l8cAo9Ro1zE06VeAOqSB0nJx9gGC61MYglcdMlF/uUEXbBFJkzRB5lJqtfd/h0Aiw4SB v7SBJBFoNygtIAcnPegiwKEAOsY9I+ISXscYVeV1D+IBzMczzgckj1BNriCFRGIIyncIyQQX8tSC euMuVbYj1+QWAHgmkKEnmORrijOGZFIWuzRPCGFzsAWHsiWHMTdd6GSH8EM6ltN098CHsqAAHRGG x7QIPnQ8ALE509BWrtAQQ3cmbeNa7eQB+lWIZIEiOMI8lwgYzWMneKInSGM77SL/OxxxM8eDiXBh iYZFdleDOchlCBKiSX2EFvZnbfRSYqRyFlahcCOUPZT3M0pxFkpVGO1jKtdRPd9XeM4hZZzFNp3R MvdjFRF0LGITMNIogbQyGPyjK+BBGyVAStNoLC44EvRTL7xRbp+RNNN0h6xRexZECMBRNxiDHuIS PrnUQcGHMebiQgTzUoiAgBnnXIdwfO/oGgaUOsCBHv+CE6eyQ4yGjzukVgTpUf7YiLAQkOzIVDlV LmZXZQf5QpUCIddhReXRkCyERl+YYyRWCBO5dOqIVF7TRp3XkcFIEv7xMve3FvBWSUjUFPoERw20 jg2Xgyy5jHE0Lw8VLCKgSBnI/2lLeUpJYxQsSEkk6SGmhB2MdDKEIIIi14qFkC8dcZSq5EpkEX41 RJZ/ZklGKBPdNR3FVEOrdE0/uJUAaViUhoXMxCOUhpeQcB7KmAjZVAhZmAhXeA50aFuF+Wt4OIiJ uUaLWZGNWVp4cxIOYRuUqU/09CjOQmSH1FP8MBrrpkTi8xKv5GlO8nPt4EGX1DFdgRYgQSFdqE53 5DpOcSHpYmma+H2yEXVwYjw2sVAUIBNExYqUsRsQYCTZqI2RdkjP0SELRnu3+D51cXf2gT5pVSH/ ZFeymJahRpFviIVg8y5zhh3ROEGng3mXEUC+1yxA8p3l6RGauJ1DaVnk533rcf8uTVgILZNCy8Eu RuJBlqMqs4kj3JkMzod82PFPRVWe/lJVPHgwUwcJoYEaA5qGMygt9Pluqqmg/8F+SgIyIGE6eskc EhqfATGfEIgx8ISfYDmANaMWHGY6VQQXHSWNq4mVjVOhzkKfS3NKKmqBSwFKAgQ1ptYgmbkjJMIn aoUcfIKbi6UjKDJw+NczNFShKPIzO0hPZzMIT2oICzWlXTGEmmmXmEZlgihAdqOM8Ng36Sh8Yrpn 3TChNed0JKpxjwmZdYpadyqGeUoRh9lye1p3fwqohpAnamEnQ4EVWsEVvIl1s4KKB3cI4ENifdEX hscXDdZ31GN/2tUTmYETK3D/ep8xet7yeeKIP5t6CHoxQzzSJ3wSNsC3MBjEXIcgL7WSNMk4Kwy6 MDZkTOpmkXJ2YVfUjWRkNKwhRad6CCwygS9UTwPIMz4JpzmSCF8xGSL4Lh64MFf5qIggNKwBI1Zx pTwjMjAhiHG6raCmZ1RoWGvabZBqO3UJXUEDZ4uJc4QVqLZnr/QqJfn6JPt6V33KW//qWwELXAMr XAWbcvaqGhOwsAzbsA77sBAbsRI7sRRbsRZ7sRbbCBq7sRzbsR77sSAbsiI7siRbsiZ7siibsiq7 sizbsi77sjAbszI7szRbszZ7szibszq7szzbsz77sy/rA0I7tERbtEK7AB67/wBGa7R+oLRL+7RH C7QpuwARMAMzYAJIgARFUARIYAJW+wFge7UnEAE+gLQauwAE8AEzkLVFMAVykLVeawJUa7VYq7VT wLVI8LVhiwRxQAZlK7Umi7YbgAFUAAIJcLgg0AZtQAWKmwRQAAI1cAZVQLYa6wNFcAZnULgJMAmJ ewYY0AALEAcb4LmGu7kJkASLSwWq67ggcAEbgACUC7glywZkMAVnALkg0ABIcAJxoAZFMAMNUAOG mwQbQABm2wi0SwBAULo1MANkQAZsgLxkEAENULoXgAB8SwDaawJVILynewZT4AOyS7ILoLQNkATC +wFLa7sJcAFJALobW74+MP8DuLsBflu+jSC/SFC/Tiu/QnsCG7C5SXAGxju+5Fu9wjsD4hu/PmAC plsDcbDAlUu/wqsDZHC8lVsEiKsDbIDBjeADJ1ADAowAEmzAILsAVYC7CtyxC0AGZ2C6JlDCftDA uGvBHjzDUyDCIKADH1u+CLzDHWzCIesDKZzAMty0fqADkJsASCDDNFzBF9yxPqAGVJAAOwyy87vE 9nvDQly5CGC4ILDCHNvCAZwAGBABHmy5mwvENzzFVQwCQMDFM2wCYLwBQdzFHusDX2zFYryxIDwJ SUDCUqzBwgsESMyxPhAHbxzHH5vFwgu/eJzHexzGTswGy5sEQBDFiEzIcHz/yH6syFbMyHmcwlbc xJEsyWAcw0SLtkAABW1QBX6bx5xsyG0MynDMxT5AABgAAu+Lv6eMyF8swlXQtV6LAA1wAWeAAATw t7K8xrQsxbbMyL6stGRwyTqAxr8sxcEsvCDQzSAABVCQBDqAADOgBjPczIXsyZUbzUgbAR3cwkig A4/bANiczcC8xAgQB/qsBnIwA1VwBuFcA0BwAkesxulcy4vswxgABDpwBkkAx0jgy/bsx5Mcw/4r tBFAypBryn48y+r8wey8AGqAAFXQAFUwA3GgtHKczXoMxn18tkSMu2cQux/s0QgdykjrtKvctGZb vj6d0znN0/kr1Ifs00P9/9ErPcST/NJnGwEYIMDq29HO/NEzzM4dO73QGwER4AfTGwFdTQZ+oNXT ywZezdUXHAEEwAZkTbta7c7P28JbrbFjnbItzcdHnL8/XAUYbNCdfNO3PMZg+wFTQM5Xi72EjQAm UAQnMAPqq7YN/AFqgLUfUAQI4AdFYALkDNn0TAAKrAbqKwdVEL0oW9eU3MgIgL65u9c2Dc0JjciM rczkjARToMCwm7YfoMwnANvhewK3TbaBnchxoLYzEAEfUAUEoAYLgASb/QFJbdoufdczfNrCq9dS fdBSTMU4Ddgm8AGY3QAE0M96jNawOwUn/QFk8AFyAMK3vcyvPcWefdJoXf8EDTAFaYsAH5C2LTza wVzaSfvDUZ3BU93G2H3FgK22SADZasvc+UwAiH3ZjO0D3O0Dsy0HCHDZEUDOJnDhvL22EC62ZFAF lJ21o13E/D3GEfDCIIABy1zdfS3FIWzFHOzBZJDWZM3VWk3Wz6vVaT3WWu0HM7DMaN20ZNC3YR29 PQ7Xau3VaA3WJ4vCKnzXED68/w3g1o3IcqDDdpzGLVy+aj3NP920ZVu+07sAbBDmYC6+Yn7OF7zA Kv3OLQy9RM3CC+DfJey0JiC8SaDXabzam4y4Wxy/BOC15fwBfLsAwm218xvDclAEjz3oBE3hc0vm iV3OWfsBwR3Bge61ZID/BIu+3WSgBikt58ubvkWLtghQA0mQAJXdxrMs0WdOx4d7xlHbwsqsx7et BsvM3QlO3E1c3D5w4DMw21WgxyQsBw2w6ep73opu32iczxDeAFFNBjOA2KLNsWwwA9wMApKLANxe BTpQA48LBOGLy5wMyULutjOgAw/dzborB+ZMtZM7v7ed4fM73LnN4GNb3MddBVXgB3Fg31d73oSt wHrcxAz+Ae5s3JarAwp8AmpAxAWMyB9ABRiAuZmruhh/BkCAACegtFjMyYL8wWpAuBhQ8RswuiVP BUDwzmAbBzNA2TyNvb9OwsJNAJS93VbL6VUgB9yNBBk90nJAAEhg3CYw69iKDbacndsur77GzcVo TQA6rr1SD/VOK7K/frhMXMJsoL1t3fVoHdeNoAYnML1qEMRxYLwEEAdbr8+0i+tpDeo5DururAbT Kwdx4AcEMAVo3Lt3Hwdj6wMRMAV0zwZqUM9jfLQXjfjN/cF0DAJ/7sdh/tPyu9dfnr9AzdNALfma P8NfbtSan/lIy8w0e7xZXOITHckdPLQNAAUNQNWnb8ALYMxZu/rXDN2vL7tE/LjgTM+2f/uAm/sC PQOu7/sGLPRqL/rEj8cqvfjJ3/zOH7I7EP3SP/3UX/3Wf/3Yn/3av/3c3/3d//z2HAgAOw== ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/nsmb_footer_logo.gif R0lGODlhdgApAKIHAMzLy1lWV+rq6qyrqzYyM4qHiCMfIP///yH5BAEAAAcALAAAAAB2ACkAAAP/ eLrcLC7KSau9ONdStP9gSBXBQBgBJAQsMawGwQbdwHaHXaAH6YvAIAVGKAACho7sAEgKdh0Bj8lD omIFAqSJE3q9zYAiDCAAqB2oYioVSwkHwSDWmn7vovbC/kz2/Ad2U1NqeIZBYXtiPTR+OwNri4mB i4WHlx+TlD1aXH+Qm1SLU3NaCxCYqRSTelUoA1ACTQYDR4OLByclAByqvg62ScEkMTZOJy47xSgs BihnwS6/0xgAqKdnCrLaQ9l51w283tTkQcbjCz405ewituhUkCbtEXJfXUA78E2QWfSy1gSswPdi AKgJAM/0AcDQGhOGqGRJHMMwnYF9r2i1M8GB/xYyGrasGKuBpEaRklY4nDhj4mIOGScKcCykL4Iu a0ikTVvXgyEgZbDEePpTQAqoE6FqHkDCMCfHInEIuXwQQNeYqTudCBwayACDoVB2LAAASWo2pjkA rdhi9kERASf64ftVxllRrjG+/kyCxEHbpS65jkFSCetSU6VMgPsFoWUJQKGu4oCC5KC1KWgBQ4N8 RObecXZEsksRJy7kvGP3eia9FrNGuC7ndFkiW4HSNVOloNhyUBULgSzCcJh1bZbKVzmrKuG7Q0ZV YZaK5TRSmYHTLFnomPrF4QYEH084GFlgo4SNF09YgNLRmMaTWuV/MwrAqwQJ9afuj09Pn57///8A 8rIYCHLAU4GAHxgEICeGgdDSXBusFE5REsCAy3+3uQMZBhl+QoEdGDYIgmAXdMhEBSAGIVN58uCn DSwv2DYVL+ON4QNZw+WQ41D1UWhbfdnocx4qvJCXYyQvHskEeKtMl514caVlUFVn1JSFNVCZ8AIB ZqgBQweeZCELD7ZwuRdMu+3gxg0lIVkGdRrN8QJhViwyhxg0qQYXDm/8QZYwLe0p45+T+cEFP1Gt 6YSPj8RR2Z1/oFJdFbgwxaUCtWVWhow41IbGHN4wpU9J4nmGTp6QcLFNWoWdOiMPPCyBKaz0QSbb pWgkaluhOPCYRKODMoUEOMBaVOhmfBLTagPht9EaWSu1diFcbBr5KQUqhfjaURejXlQdeXbQ+Fla NdACVoNKSdEBrF4pQokmiDpXwiko9MLprJ06EYOkYoi6bxxFxSQLfZDC0I8fPMSyELNT7SBQwtWC uklmYpIw4B9mDPZMSE09c6cNZtQFJwrSzOGMH7DRId0zuljhwk0MfJzFC83h5AJ7zdXCJSzSWHFy f7pSBFFDRDcUB4xCOwTjNXLUePQLFSXEkExxWFN0A03HKDWmOW6dNbYyQdnFvAuWLcEcDcAyBhxm t512vTjSJxPZbtedw3PumQyh3XxXDU8CADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/rj_globnavimages/npg_footer_logo.gif R0lGODlhGgAaAKIHAAEBAW5uburq6pOTk7i4uCsrK1NTU////yH5BAEAAAcALAAAAAAaABoAAAPP eLoqFKaUEAi7WATAux8Cdg1e6RWWqJlsN4hbK78MKd/pIdx8ER4x3kxXIBkgrgil0DlGAIUDQSAY BECbgJRCZRJIWocmsOMQCBxgxxFlAlaDYxkwQAMOBpfAcHCvAhNzdWl5HCBvJD4cSoJ2eB1fAAZf QQZyLo4xPhJzHVdnG5MPdw4DA0w+VWckgy2PJZMUIFOdJa8dKB4GPzYmt4Z2HFoNbicHvYvHEhUM wZ4UhU2mgD8LyEJmItc3KCIKBMUyPt4LVeG6OeQMVRSf1RgJADs= ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/includes/prdct_img/go.gif R0lGODlhGgATAJEAAAAAAP///4CAgMDAwCH5BAAAAAAALAAAAAAaABMAAAJPjI+pCDEPo5xPtAGy 3rwD63iiB2LjmZUoqnIMe7mBNp8tXW+vdmeG7Mt9YrrZoVH78Yi4INK5DMmOSGXUtBL1spwt9/ol NQTksvmMLodRBQA7 ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nsmb/style_older.css A.topnav { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Tahoma, Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.topnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Tahoma, Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.topnav:hover { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Tahoma, Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.topnavsml { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.topnavsml:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.topnavsml:hover { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .leftnavOn { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2:visited { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on:visited { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on:hover { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3 { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred:visited { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.closewindow { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2 { FONT-SIZE: 10px; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2:hover { FONT-SIZE: 10px; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2:visited { FONT-SIZE: 10px; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .search { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } A.adsearch { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.adsearch:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.adsearch:hover { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .breadcrumb { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.breadcrumblink { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.breadcrumblink:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.breadcrumblink:hover { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .whitesml2 { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.whitesml2 { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.whitesml2:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.whitesml2:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .login { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.redsml { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.redsml:visited { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.redsml:hover { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction { FONT-SIZE: small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction:visited { FONT-SIZE: small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction:hover { FONT-SIZE: small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2:visited { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .date { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .subjecttitle { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .subjecttext { FONT-SIZE: 10px; COLOR: #990000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.linksml { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.linksml:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.linksml:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2 { FONT-SIZE: small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2:visited { FONT-SIZE: small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2:hover { FONT-SIZE: small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth { FONT-SIZE: x-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth:visited { FONT-SIZE: x-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth:hover { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #691f94; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle:visited { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #691f94; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle:hover { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .authorname { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .author { FONT-SIZE: small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .seealso { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .freeaccess { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .greysml { FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: #cccccc; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } .redsml2 { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .blacksml { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .whitesml { FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: #ffffff; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } .webfocustext { FONT-SIZE: 11px; COLOR: #56177b; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .pagenum { FONT-SIZE: small; COLOR: #999999; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .pagenum2 { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .blacksml2 { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .blacksmltext { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .blacknorm { FONT-SIZE: 11px; COLOR: #000000; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.bodylink { FONT-SIZE: 12px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink:visited { FONT-SIZE: 12px; COLOR: #990099; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink:hover { FONT-SIZE: 12px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2 { FONT-SIZE: 11px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2:visited { FONT-SIZE: 11px; COLOR: #990099; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2:hover { FONT-SIZE: 11px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink { FONT-SIZE: x-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink:visited { FONT-SIZE: x-small; COLOR: #925ab1; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink:hover { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink:visited { FONT-SIZE: 10px; COLOR: #990099; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink:hover { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.login { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.login:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.login:hover { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor { FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.anchor:visited { FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.anchor:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .articlelink { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .bottomnav { FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.bottomnav { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; = FONT-STYLE: normal; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A.bottomnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; = FONT-STYLE: normal; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A.bottomnav:hover { FONT-SIZE: 11px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.copyright { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.copyright:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.copyright:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.privacy { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.privacy:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.privacy:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A { COLOR: #691f94; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A:hover { COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A:visited { COLOR: #691f94; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A.footer { FONT-SIZE: 11px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.footer:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.footer:visited { FONT-SIZE: 11px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink:hover { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink:visited { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml { FONT-SIZE: 10px; COLOR: #691f94; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml:hover { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml:visited { FONT-SIZE: 10px; COLOR: #691f94; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .sponsor { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #990066; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .introtext { FONT-SIZE: 12px; COLOR: #000000; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .browsetext { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .browsehighlight { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #006666; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } A.browselink { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.browselink:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.browselink:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .heading1 { FONT-WEIGHT: bold; FONT-SIZE: medium; COLOR: #56177b; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } H2 { FONT-WEIGHT: bold; FONT-SIZE: large; COLOR: #000000; FONT-FAMILY: = Georgia, Times New Roman, Times, serif } .heading3 { FONT-WEIGHT: bold; FONT-SIZE: small; TEXT-TRANSFORM: uppercase; COLOR: = #56177b; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .heading4 { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .table1 { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .table2 { FONT-SIZE: small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .table3 { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .archivehead { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articleareatitle { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #006666; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .articleinfo { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articletitle { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #000000; FONT-FAMILY: = Georgia, Times New Roman, Times, serif } .articletext { FONT-SIZE: small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .faq { FONT-SIZE: small; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .quote { FONT-SIZE: small; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .doi { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .divider { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .specialoffer { FONT-SIZE: small; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articleinfo2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articleinfodate { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .bodytext { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #000000; LINE-HEIGHT: = 15px; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .subtitle { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; LINE-HEIGHT: 15px; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .toctitle { FONT-WEIGHT: bold; FONT-SIZE: medium; COLOR: #691f94; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .lgn_border { COLOR: #eadef2 } .lgn_background { COLOR: #eadef2 } .lgn_text { FONT-SIZE: 10px; COLOR: #000000; LINE-HEIGHT: 11px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } A.lgn_text { COLOR: #56177b; TEXT-DECORATION: underline } A.lgn_text:link { COLOR: #56177b; TEXT-DECORATION: underline } A.lgn_text:visited { COLOR: #384955; TEXT-DECORATION: underline } A.lgn_text:hover { COLOR: #cc3300; TEXT-DECORATION: underline } .lgn_textbig { FONT-SIZE: 11px; COLOR: #000000; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } .lgn_textalt { FONT-SIZE: 11px; COLOR: #384955; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } .lgn_textred { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 11px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } .lgn_textbox { PADDING-LEFT: 0px; FONT-SIZE: 11px; MARGIN-LEFT: 0px; COLOR: #000000; = FONT-FAMILY: Verdana, Arial, Geneva, sans-serif } .boxbar { FONT-WEIGHT: bold; FONT-SIZE: xx-small; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .boxtitle { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .boxlink { FONT-SIZE: xx-small; COLOR: #56177b; LINE-HEIGHT: 1.5; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .boxlink:visited { COLOR: #56177b } .boxlink:hover { COLOR: #56177b } .boxlinkedtitle { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #56177b; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .boxlinkedtitle:visited { COLOR: #56177b } .boxlinkedtitle:hover { COLOR: #56177b } .boxtext { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .boxseealso { FONT-WEIGHT: bold; FONT-SIZE: xx-small; COLOR: #cc0033; LINE-HEIGHT: = 1.5; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } TD { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: none } .jbs_red { FONT-WEIGHT: normal; COLOR: #cc3300; TEXT-DECORATION: underline } .jbs_red:hover { FONT-WEIGHT: normal; COLOR: #000000; TEXT-DECORATION: underline } .jbs_red:visited { FONT-WEIGHT: normal; TEXT-DECORATION: underline } .prdnorm { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: none } A.prd_red { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #cc3300; = TEXT-DECORATION: underline } A.prd_red:hover { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } A.prd_red:visited { FONT: 10px Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = underline } .smallcaps { FONT-SIZE: x-small; TEXT-TRANSFORM: uppercase; COLOR: #000000; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .jbsnorm { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: none } A.jbslink { FONT: bold 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } A.jbslink:hover { FONT: bold 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #cc3300; = TEXT-DECORATION: underline } A.jbslink:visited { FONT: bold 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } .jbs_red { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #cc3300; = TEXT-DECORATION: underline } .jbs_red:hover { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } .jbs_red:visited { FONT: 10px Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = underline } .smallcaps { FONT-SIZE: xx-small; TEXT-TRANSFORM: uppercase; COLOR: #000000; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/table_sites/naturejobs.css .natjob { FONT-FAMILY: Verdana, arial, Helvetica, sans-serif } .natjobmore { FONT-FAMILY: Verdana, arial, Helvetica, sans-serif } H2.natjob { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: black = 1px solid; PADDING-LEFT: 4px; PADDING-BOTTOM: 2px; MARGIN: 0px; FONT: = bold 12px georgia; BORDER-LEFT: black 1px solid; PADDING-TOP: 1px; = BORDER-BOTTOM: black 1px solid; LETTER-SPACING: -0.04em } H2.natjob A { TEXT-DECORATION: none } H2.natjob SPAN.first { COLOR: #f44 } H2.natjob SPAN.second { COLOR: #444 } UL.natjob { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: 0px; = PADDING-LEFT: 4px; BACKGROUND: #f3f2f2; PADDING-BOTTOM: 4px; MARGIN: = 0px; BORDER-LEFT: black 1px solid; PADDING-TOP: 4px; BORDER-BOTTOM: = black 1px solid; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.natjob H3 { FONT-WEIGHT: bold; FONT-SIZE: 10px; MARGIN: 10px 0px 0px } UL.natjob H3.first { MARGIN: 0px } UL.natjob H3 A:link { COLOR: #000; TEXT-DECORATION: underline } UL.natjob H3 A:visited { COLOR: #000; TEXT-DECORATION: underline } DIV.natjobmore { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: 0px; = PADDING-LEFT: 4px; BACKGROUND: #f3f2f2; MARGIN-BOTTOM: 15px; = PADDING-BOTTOM: 6px; BORDER-LEFT: black 1px solid; PADDING-TOP: 4px; = BORDER-BOTTOM: black 1px solid } DIV.natjobmore A:link { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 10px; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: underline } DIV.natjobmore A:visited { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 10px; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: underline } UL.natjob UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10px; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } P.natjobmore { PADDING-BOTTOM: 5px; MARGIN: 0px } P.nateventmore { PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: 5px } ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/table_sites/abad.css DIV.ab-ad { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 10px; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 3px; MARGIN: 15px 0px; PADDING-TOP: 0px; = FONT-FAMILY: Verdana, arial, Helvetica, sans-serif; TEXT-ALIGN: center } DIV.ab-ad H2.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H4.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H5.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H6.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad H6.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad DIV.container { BORDER-RIGHT: #e0ebf9 1px solid; BORDER-TOP: #e0ebf9 1px solid; = MARGIN-TOP: 3px; BORDER-LEFT: #e0ebf9 1px solid; BORDER-BOTTOM: #e0ebf9 = 1px solid; BACKGROUND-COLOR: #fff } DIV.ab-ad UL { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 5px; MARGIN: 0px; TEXT-TRANSFORM: none; PADDING-TOP: = 5px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } DIV.ab-ad UL UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } DIV.ab-ad LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: = 0px; PADDING-TOP: 2px } DIV.ab-ad A { COLOR: #0068b3 } DIV.ab-ad A.sponsor IMG { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BORDER-LEFT: 0px; WIDTH: 100%; = BORDER-BOTTOM: 0px; max-width: 118px } DIV.ab-ad P.blurb { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 5px 5px; PADDING-TOP: 0px; TEXT-ALIGN: left } ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/table_sites/header_footer_shared.css HTML #head-er { FONT-SIZE: 62.5% } HTML #foot-er { FONT-SIZE: 62.5% } HTML #head-er { FONT-SIZE: 63% } HTML #foot-er { FONT-SIZE: 63% } #head-er { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 62.5%; BACKGROUND: = #fff; PADDING-BOTTOM: 20px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 0px; = FONT-FAMILY: Verdana, arial, Helvetica, sans-serif } #foot-er { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 62.5%; BACKGROUND: = #fff; PADDING-BOTTOM: 20px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 0px; = FONT-FAMILY: Verdana, arial, Helvetica, sans-serif } #head-er .hidden { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } #foot-er .hidden { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } #head-er .clearfix:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } #foot-er .clearfix:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } HTML #head-er .clearfix { HEIGHT: 1% } HTML #foot-er .clearfix { HEIGHT: 1% } #head-er DIV.cleardiv { CLEAR: both; PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! = important; PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #foot-er DIV.cleardiv { CLEAR: both; PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! = important; PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #head-er .button { FONT-WEIGHT: bold; FONT-SIZE: 80%; COLOR: #fff; BACKGROUND-COLOR: #000 } #foot-er .button { FONT-WEIGHT: bold; FONT-SIZE: 80%; COLOR: #fff; BACKGROUND-COLOR: #000 } #head-er .b { FONT-WEIGHT: bold } #foot-er .b { FONT-WEIGHT: bold } #head-er .i { FONT-STYLE: italic } #foot-er .i { FONT-STYLE: italic } #head-er SPAN.journalname { FONT-STYLE: italic } #foot-er SPAN.journalname { FONT-STYLE: italic } #head-er SPAN.journalnumber { FONT-WEIGHT: bold } #foot-er SPAN.journalnumber { FONT-WEIGHT: bold } #head-er HR { DISPLAY: none } #foot-er HR { DISPLAY: none } ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/includes/header/style/table_sites/header.css #head-er HR { DISPLAY: none } #head-er .header-nonad-wrapper { PADDING-BOTTOM: 15px; BORDER-BOTTOM: #fff 1px solid } #head-er .accessibility-login-wrap { FLOAT: left; WIDTH: 100%; BORDER-BOTTOM: #000 1px solid; = BACKGROUND-COLOR: #eaeaea } #head-er .accessibility-login { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 4px; TEXT-ALIGN: right } #head-er .accessibility-login A.nature-link { FLOAT: left; FONT: bold 160%/80% Garamond, serif; WIDTH: 4.9em; COLOR: = #b1062e; MARGIN-RIGHT: 20px; TEXT-ALIGN: left; TEXT-DECORATION: none } HTML #head-er .accessibility-login A.nature-link:hover { BACKGROUND: none transparent scroll repeat 0% 0% } #head-er .accessibility-login A.nature-link:hover { BACKGROUND: url(/test/images/nature.com.underline.gif) no-repeat left = bottom } #head-er .accessibility-login IMG.nature-logo { BORDER-RIGHT: 0px; BORDER-TOP: 0px; FLOAT: left; MARGIN: 1px 20px 0px = 0px; BORDER-LEFT: 0px; WIDTH: 102px; BORDER-BOTTOM: 0px; HEIGHT: 11px } #head-er .accessibility-login .jumplinks { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 45%; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } #head-er .accessibility-login .jumplinks LI { DISPLAY: inline; PADDING-LEFT: 15px } #head-er .accessibility-login .jumplinks LI.first { PADDING-LEFT: 0px } #head-er .accessibility-login .jumplinks A { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/b1062e/arrow_down.gif) no-repeat left center; = COLOR: #000; TEXT-DECORATION: none } #head-er .accessibility-login .jumplinks A:hover { TEXT-DECORATION: underline } #head-er .logon .onlyformacie { FONT-SIZE: 3px } #head-er .logon .onlyformacie { DISPLAY: none } #head-er .logon A.login { PADDING-RIGHT: 15px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logon.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon A.login:hover { BACKGROUND: url(/common/includes/header/images/logon_over.gif) = no-repeat right center; TEXT-DECORATION: underline } #head-er .logon A.login:active { BACKGROUND: url(/common/includes/header/images/logon.gif) no-repeat = right center } #head-er .logon A.logoff { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logoff.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon P { MARGIN: 0px } #head-er .logon .user { FONT-WEIGHT: bold } #head-er .logon .inst { FONT-WEIGHT: bold } #head-er .image-user-services-wrap { FLOAT: left; WIDTH: 100%; BACKGROUND-COLOR: #d6335c } #head-er .image-user-services { BORDER-BOTTOM: transparent 1px solid } HTML #head-er .image-user-services { BORDER-BOTTOM: 0px } #head-er .image-user-services IMG.journal-header { BORDER-RIGHT: 0px; BORDER-TOP: 0px; FLOAT: left; MARGIN: 0px; = BORDER-LEFT: 0px; WIDTH: 344px; BORDER-BOTTOM: 0px; HEIGHT: 74px } #head-er .user-services { FLOAT: right } #head-er .div1 { WIDTH: 12.7em! important } #head-er .div2 { WIDTH: 8.7em! important } #head-er .user-services UL { BORDER-RIGHT: #fff 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: #fff 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 22px 0px 21px; = BORDER-LEFT: #fff 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 0px = solid; LIST-STYLE-TYPE: none; TEXT-ALIGN: right } #head-er .user-services UL.list1 { BORDER-RIGHT: #fff 1px solid } #head-er .user-services LI { BORDER-BOTTOM: #fff 1px solid } #head-er .user-services A { PADDING-RIGHT: 13px; DISPLAY: block; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) #767474 no-repeat right = center; PADDING-BOTTOM: 1px; TEXT-TRANSFORM: uppercase; COLOR: #fff; = PADDING-TOP: 1px; TEXT-DECORATION: none } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .publications-search-wrap { BACKGROUND: #000 } HTML #head-er .publications-search { PADDING-BOTTOM: 3px; PADDING-TOP: 3px } #head-er .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 4px; = PADDING-TOP: 4px } HTML #head-er .publications { MARGIN: 6px 0px 0px } #head-er .publications { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4px 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #head-er .publications LI { DISPLAY: inline; MARGIN-LEFT: 10px } #head-er .publications LI.first { MARGIN-LEFT: 0px } #head-er .publications A { PADDING-RIGHT: 15px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .publications A:hover { TEXT-DECORATION: underline } #head-er .search { TEXT-ALIGN: right } #head-er .search FORM { DISPLAY: inline; MARGIN: 0px } #head-er .search FORM A { PADDING-RIGHT: 14px; FONT-WEIGHT: normal; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .search FORM A:hover { TEXT-DECORATION: underline } #head-er #searchtext { FONT-WEIGHT: normal; FONT-SIZE: 80%; WIDTH: 10em } #head-er .publications-search LABEL { FONT-WEIGHT: normal; FONT-SIZE: 80%; TEXT-TRANSFORM: uppercase; COLOR: = #fff } #head-er INPUT { FONT-WEIGHT: normal; FONT-SIZE: 80% } #head-er SELECT { FONT-WEIGHT: normal; FONT-SIZE: 80% } #head-er .publications-search INPUT.button { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px } #head-er .accessibility-login { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .image-user-services { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .publications-search { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } .header-leaderboard-wrap { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: = url(/common/includes/header/images/bg_leaderboard.gif) #eaeaea no-repeat = 50% 0px } .header-leaderboard { MARGIN: 0px 0px 15px; TEXT-ALIGN: center } .header-leaderboard IMG { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; VERTICAL-ALIGN: bottom; = BORDER-LEFT: 0px; WIDTH: 100%; PADDING-TOP: 0px; BORDER-BOTTOM: 0px; = HEIGHT: 90px; max-width: 728px } .header-leaderboard ilayer { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; VERTICAL-ALIGN: bottom; = BORDER-LEFT: 0px; WIDTH: 100%; PADDING-TOP: 0px; BORDER-BOTTOM: 0px; = HEIGHT: 90px; max-width: 728px } .header-leaderboard IFRAME { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; VERTICAL-ALIGN: bottom; = BORDER-LEFT: 0px; WIDTH: 100%; PADDING-TOP: 0px; BORDER-BOTTOM: 0px; = HEIGHT: 90px; max-width: 728px } .header-leaderboard EMBED { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; VERTICAL-ALIGN: bottom; = BORDER-LEFT: 0px; WIDTH: 100%; PADDING-TOP: 0px; BORDER-BOTTOM: 0px; = HEIGHT: 90px; max-width: 728px } .header-leaderboard TABLE { MARGIN-LEFT: auto; MARGIN-RIGHT: auto } ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/style/restrict_width/760px.css #head-er .accessibility-login { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN: 0px auto; WIDTH: 760px } #head-er .image-user-services { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN: 0px auto; WIDTH: 760px } #head-er .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN: 0px auto; WIDTH: 760px } HTML #head-er .accessibility-login-wrap { TEXT-ALIGN: center } HTML #head-er .image-user-services-wrap { TEXT-ALIGN: center } HTML #head-er .publications-search-wrap { TEXT-ALIGN: center } .header-leaderboard IMG { WIDTH: 728px } .header-leaderboard ilayer { WIDTH: 728px } .header-leaderboard IFRAME { WIDTH: 728px } .header-leaderboard EMBED { WIDTH: 728px } #head-er { PADDING-BOTTOM: 0px } ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nsmb/style.css @import url( /common/style/table_sites/naturejobs.css ); @import url( /common/style/table_sites/abad.css ); @import url( /common/style/table_sites/header_footer_shared.css ); @import url( /common/includes/header/style/table_sites/header.css ); @import url( /common/style/restrict_width/760px.css ); #head-er .image-user-services-wrap { BACKGROUND-COLOR: #56177b } #head-er .image-user-services IMG.journal-header { WIDTH: 188px } #head-er .image-user-services { BACKGROUND: url(/includes/rj_globnavimages/nsmb_bg_header.gif) = no-repeat right top } #head-er .user-services A { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #320e47 no-repeat = right center } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } A.topnav { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Tahoma, Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.topnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Tahoma, Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.topnav:hover { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Tahoma, Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.topnavsml { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.topnavsml:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.topnavsml:hover { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .leftnavOn { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnavOn:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2:visited { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on:visited { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav2on:hover { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3 { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.leftnav3On:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subject:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred:visited { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.subjectred:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Arial, Verdana, = Helvetica, sans-serif; TEXT-DECORATION: none } A.closewindow { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2 { FONT-SIZE: 10px; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2:hover { FONT-SIZE: 10px; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.closewindow2:visited { FONT-SIZE: 10px; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .search { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } A.adsearch { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.adsearch:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.adsearch:hover { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .breadcrumb { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.breadcrumblink { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.breadcrumblink:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.breadcrumblink:hover { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .whitesml2 { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.whitesml2 { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.whitesml2:visited { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.whitesml2:hover { FONT-SIZE: 10px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .login { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.redsml { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.redsml:visited { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.redsml:hover { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction:visited { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.retraction:hover { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.blacksml2:visited { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.top:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } .date { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .subjecttitle { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .subjecttext { FONT-SIZE: 10px; COLOR: #990000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } A.linksml { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.linksml:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.linksml:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2 { FONT-SIZE: x-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2:visited { FONT-SIZE: x-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor2:hover { FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth { FONT-SIZE: xx-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth:visited { FONT-SIZE: xx-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.archivemonth:hover { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #691f94; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle:visited { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #691f94; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articletitle:hover { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .authorname { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .author { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .seealso { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .freeaccess { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .greysml { FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: #cccccc; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } .redsml2 { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .blacksml { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .whitesml { FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: #ffffff; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } .webfocustext { FONT-SIZE: 11px; COLOR: #56177b; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .pagenum { FONT-SIZE: x-small; COLOR: #999999; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .pagenum2 { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .blacksml2 { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .blacksmltext { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .blacknorm { FONT-SIZE: 11px; COLOR: #000000; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A.bodylink { FONT-SIZE: 12px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink:visited { FONT-SIZE: 12px; COLOR: #990099; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink:hover { FONT-SIZE: 12px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2 { FONT-SIZE: 11px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2:visited { FONT-SIZE: 11px; COLOR: #990099; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.bodylink2:hover { FONT-SIZE: 11px; COLOR: #0000ff; LINE-HEIGHT: 15px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink { FONT-SIZE: xx-small; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink:visited { FONT-SIZE: xx-small; COLOR: #925ab1; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.contentslink:hover { FONT-SIZE: xx-small; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink:visited { FONT-SIZE: 10px; COLOR: #990099; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.articlelink:hover { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.login { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.login:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.login:hover { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.anchor { FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.anchor:visited { FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.anchor:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .articlelink { FONT-SIZE: 10px; COLOR: #0000ff; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .bottomnav { FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.bottomnav { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; = FONT-STYLE: normal; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A.bottomnav:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; LINE-HEIGHT: 14px; = FONT-STYLE: normal; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A.bottomnav:hover { FONT-SIZE: 11px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.copyright { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.copyright:visited { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.copyright:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } A.privacy { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.privacy:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.privacy:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A { COLOR: #691f94; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A:hover { COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A:visited { COLOR: #691f94; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } A.footer { FONT-SIZE: 11px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.footer:hover { FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.footer:visited { FONT-SIZE: 11px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink:hover { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.greysmllink:visited { FONT-SIZE: 10px; COLOR: #666666; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav:hover { FONT-SIZE: 10px; COLOR: #cc3300; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.popnav:visited { FONT-SIZE: 10px; COLOR: #691f94; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml { FONT-SIZE: 10px; COLOR: #691f94; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml:hover { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } A.sml:visited { FONT-SIZE: 10px; COLOR: #691f94; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .sponsor { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #990066; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .introtext { FONT-SIZE: 12px; COLOR: #000000; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .browsetext { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .browsehighlight { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #006666; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } A.browselink { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.browselink:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666666; FONT-STYLE: normal; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = none } A.browselink:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #cc3300; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .tocnext { FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .heading1 { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #56177b; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } H2 { FONT-WEIGHT: bold; FONT-SIZE: medium; COLOR: #000000; FONT-FAMILY: = Georgia, Times New Roman, Times, serif } .heading3 { FONT-WEIGHT: bold; FONT-SIZE: x-small; TEXT-TRANSFORM: uppercase; = COLOR: #56177b; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .heading4 { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .table1 { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .table2 { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .table3 { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .archivehead { FONT-SIZE: 11px; COLOR: #ffffff; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articleareatitle { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #006666; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .articleinfo { FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articletitle { FONT-WEIGHT: bold; FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: = Georgia, Times New Roman, Times, serif } .articletext { FONT-SIZE: x-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .faq { FONT-SIZE: x-small; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .quote { FONT-SIZE: x-small; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .doi { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .divider { FONT-SIZE: xx-small; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .specialoffer { FONT-SIZE: x-small; COLOR: #56177b; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articleinfo2 { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } .articleinfodate { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .bodytext { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #000000; LINE-HEIGHT: = 15px; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .subtitle { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; LINE-HEIGHT: 15px; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .toctitle { FONT-WEIGHT: bold; FONT-SIZE: small; COLOR: #691f94; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif } .categ_small { FONT-WEIGHT: bold; FONT-SIZE: 14px; TEXT-TRANSFORM: uppercase; COLOR: = #56177b; LINE-HEIGHT: 2; FONT-FAMILY: Tahoma, Arial, Helvetica, = sans-serif; TEXT-DECORATION: none } .categ_large { FONT-SIZE: 18px; TEXT-TRANSFORM: uppercase; COLOR: #56177b; = LINE-HEIGHT: 2; FONT-FAMILY: Tahoma, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } .uppercase { TEXT-TRANSFORM: uppercase } .lgn_border { BACKGROUND-COLOR: #eadef2 } .lgn_background { BACKGROUND-COLOR: #eadef2 } .lgn_text { FONT-SIZE: 10px; COLOR: #000000; LINE-HEIGHT: 11px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } A.lgn_text { COLOR: #56177b; TEXT-DECORATION: underline } A.lgn_text:link { COLOR: #56177b; TEXT-DECORATION: underline } A.lgn_text:visited { COLOR: #384955; TEXT-DECORATION: underline } A.lgn_text:hover { COLOR: #cc3300; TEXT-DECORATION: underline } .lgn_textbig { FONT-SIZE: 11px; COLOR: #000000; LINE-HEIGHT: 14px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } .lgn_textalt { FONT-SIZE: 11px; COLOR: #384955; LINE-HEIGHT: 16px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } .lgn_textred { FONT-SIZE: 10px; COLOR: #cc3300; LINE-HEIGHT: 11px; FONT-FAMILY: = Verdana, Arial, Geneva, sans-serif } .lgn_textbox { PADDING-LEFT: 0px; FONT-SIZE: 11px; MARGIN-LEFT: 0px; COLOR: #000000; = FONT-FAMILY: Verdana, Arial, Geneva, sans-serif } .boxbar { FONT-WEIGHT: bold; FONT-SIZE: xx-small; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .boxtitle { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: none } .boxlink { FONT-SIZE: xx-small; COLOR: #56177b; LINE-HEIGHT: 1.5; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .boxlink:visited { COLOR: #56177b } .boxlink:hover { COLOR: #56177b } .boxlinkedtitle { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #56177b; FONT-FAMILY: = Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: underline } .boxlinkedtitle:visited { COLOR: #56177b } .boxlinkedtitle:hover { COLOR: #56177b } .boxtext { FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-DECORATION: none } .boxseealso { FONT-WEIGHT: bold; FONT-SIZE: xx-small; COLOR: #cc0033; LINE-HEIGHT: = 1.5; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } TD { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: none } .jbs_red { FONT-WEIGHT: normal; COLOR: #cc3300; TEXT-DECORATION: underline } .jbs_red:hover { FONT-WEIGHT: normal; COLOR: #000000; TEXT-DECORATION: underline } .jbs_red:visited { FONT-WEIGHT: normal; TEXT-DECORATION: underline } .prdnorm { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: none } A.prd_red { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #cc3300; = TEXT-DECORATION: underline } A.prd_red:hover { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } A.prd_red:visited { FONT: 10px Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = underline } .smallcaps { FONT-SIZE: xx-small; TEXT-TRANSFORM: uppercase; COLOR: #000000; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .jbsnorm { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: none } A.jbslink { FONT: bold 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } A.jbslink:hover { FONT: bold 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #cc3300; = TEXT-DECORATION: underline } A.jbslink:visited { FONT: bold 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } .jbs_red { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #cc3300; = TEXT-DECORATION: underline } .jbs_red:hover { FONT: 10px Verdana, Arial, Helvetica, sans-serif; COLOR: #000000; = TEXT-DECORATION: underline } .jbs_red:visited { FONT: 10px Verdana, Arial, Helvetica, sans-serif; TEXT-DECORATION: = underline } .smallcaps { FONT-SIZE: xx-small; TEXT-TRANSFORM: uppercase; COLOR: #000000; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } ------=_NextPart_000_0084_01C66AA7.3ECF6620 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/mailafriend/mailafriend.js function mailafriend(url, form_url, width, height){ if(url=3D=3D0){ url =3D escape(document.URL); } var title =3D escape(document.title).replace(/\+/i, "%2b"); var open_url =3D form_url + "?url=3D" + url + "&title=3D" + title; var params =3D "width=3D" + width + ",height=3D" + height + = ",resizable=3Dyes,location=3Dno,menubar=3Dno,scrollbars=3Dyes,personalbar= =3Dno,status=3Dyes,top=3D10,left=3D10"; window.open(open_url,'mailafriend',params); } ------=_NextPart_000_0084_01C66AA7.3ECF6620--