From: Subject: Cancer Cell -- Phillips et al. Date: Sat, 13 May 2006 13:08:37 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_000B_01C6768E.59148B30" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_000B_01C6768E.59148B30 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cancercell.org/content/article/abstract?uid=PIIS1535610806000560 =EF=BB=BF Cancer Cell -- Phillips et = al. =
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Copyright =C2=A9 2006 Cell Press. All = rights=20 reserved.
Cancer Cell, Vol 9, 157-173, March 2006

Article

Molecular subclasses of = high-grade=20 glioma predict prognosis, delineate a pattern of disease = progression, and=20 resemble stages in neurogenesis

Heidi=20 S. Phillips,1, Samir Kharbanda,= 1=20 Ruihuan Chen,1=20 William=20 F. Forrest,2=20 Robert=20 H. Soriano,3=20 Thomas = D. Wu,4=20 Anjan Misra,5=20 Janice=20 M. Nigro,5=20 Howard Colman,6=20 Liliana Sorocean= u,1=20 P.=20 Mickey Williams,3=20 Zora Modrusan,3=20 Burt=20 G. Feuerstein,5=20 and Ken Aldape7=20

1 Department of=20 Tumor Biology and Angiogenesis, Genentech, Inc., South San = Francisco,=20 California 940802 Department of=20 Biostatistics, Genentech, Inc., South San Francisco, California=20 94080
3 Department of=20 Molecular Biology, Genentech, Inc., South San Francisco, = California=20 94080
4 Department of=20 Bioinformatics, Genentech, Inc., South San Francisco, California=20 94080
5 Brain Tumor=20 Research Center, University of California, San Francisco, San = Francisco,=20 California 941436 Department of=20 Neuro-Oncology, M.D. Anderson Cancer Center, Houston, Texas=20 77030
7 Department of=20 Pathology, M.D. Anderson Cancer Center, Houston, Texas = 77030

Correspondence:
Heidi S. Phillips
Ph: 650 = 225 2657;=20 Fax: 650 225 4000
hsp@gene.com
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Summary

Previously undescribed prognostic = subclasses=20 of high-grade astrocytoma are identified and discovered to = resemble stages=20 in neurogenesis. One tumor class displaying neuronal lineage = markers shows=20 longer survival, while two tumor classes enriched for neural stem = cell=20 markers display equally short survival. Poor prognosis subclasses = exhibit=20 markers either of proliferation or of angiogenesis and mesenchyme. = Upon=20 recurrence, tumors frequently shift toward the mesenchymal = subclass.=20 Chromosomal locations of genes distinguishing tumor subclass = parallel DNA=20 copy number differences between subclasses. Functional relevance = of tumor=20 subtype molecular signatures is suggested by the ability of cell = line=20 signatures to predict neurosphere growth. A robust two-gene = prognostic=20 model utilizing PTEN and DLL3 expression suggests that Akt and = Notch=20 signaling are hallmarks of poor prognosis versus better prognosis = gliomas,=20 respectively.


 Cell  Immunity  Neuron  Molecular=20 Cell  Structure
 Current=20 Biology  Developmental = Cell  Cancer Cell  Chemistry &=20 Biology  Cell=20 Metabolism


Copyright 2006 Elsevier = Inc.
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MARGIN-LEFT: 10px } UL.article_lists { MARGIN-TOP: 5px; PADDING-LEFT: 10px; LIST-STYLE-IMAGE: = url(../../webfiles/images/ccell/light_sub_bullet.png); MARGIN-BOTTOM: = 10px; MARGIN-LEFT: 10px; LINE-HEIGHT: 12px } TD.cover_image_header { PADDING-LEFT: 4px; WIDTH: 194px; BORDER-BOTTOM: #666666 1px solid; = HEIGHT: 16px; BACKGROUND-COLOR: #666666 } TD.cover_image_header_blank { BORDER-BOTTOM: #666666 1px solid; HEIGHT: 16px; BACKGROUND-COLOR: = #ffffff } TD.cover_image_header_quickjump { WIDTH: 220px; BORDER-BOTTOM: #666666 1px solid; HEIGHT: 16px; = BACKGROUND-COLOR: #ffffff } H1.article_title { FONT-WEIGHT: bold; FONT-SIZE: 17px; COLOR: #666666; FONT-FAMILY: = Verdana, Arial, Helvetica, sans_serif } .corner_l_align { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; VERTICAL-ALIGN: top; WIDTH: 10px; PADDING-TOP: 0px; BORDER-BOTTOM: = #666666 1px solid; BACKGROUND-COLOR: #666666; TEXT-ALIGN: left } .section_header { PADDING-LEFT: 4px; WIDTH: 200px; BORDER-BOTTOM: #666666 1px solid; = BACKGROUND-COLOR: #666666 } .section_header_blank { WIDTH: 520px; BORDER-BOTTOM: #666666 1px solid; HEIGHT: 16px; = BACKGROUND-COLOR: #ffffff } .section_header_blank_sm { WIDTH: 320px; BORDER-BOTTOM: #666666 1px solid; HEIGHT: 16px; = BACKGROUND-COLOR: #ffffff } A { COLOR: #666666; TEXT-DECORATION: underline } A:visited { COLOR: #333333; TEXT-DECORATION: underline } A:hover { COLOR: #333333; TEXT-DECORATION: none } A.ja50-ce-cross-ref { COLOR: #666666; TEXT-DECORATION: underline } A.ja50-ce-cross-ref:visited { COLOR: #333333; TEXT-DECORATION: underline } A.ja50-ce-cross-ref:hover { COLOR: #333333; TEXT-DECORATION: none } A.article_content_link { COLOR: #666666; TEXT-DECORATION: underline } A.article_content_link:visited { COLOR: #333333; TEXT-DECORATION: underline } A.article_content_link:hover { COLOR: #000000; TEXT-DECORATION: none } A.cover_caption_link { FONT-SIZE: 11px; COLOR: #666666; TEXT-DECORATION: underline } A.cover_caption_link:visited { FONT-SIZE: 11px; COLOR: #333333; TEXT-DECORATION: underline } A.cover_caption_link:hover { FONT-SIZE: 11px; COLOR: #000000; TEXT-DECORATION: none } .content_header_darkcolor { FONT-WEIGHT: bold; COLOR: #666666; BACKGROUND-COLOR: #ffff00 } ------=_NextPart_000_000B_01C6768E.59148B30 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cancercell.org/webfiles/css/fla_styles.css .subTitle { FONT-WEIGHT: bold } .paraFont { LINE-HEIGHT: 1.4 } .content_table { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } TD.content_spacer { WIDTH: 10px } TD.magazine_content_header { PADDING-LEFT: 4px; BORDER-LEFT: #89a367 1px solid; WIDTH: 290px; = BORDER-BOTTOM: #89a367 1px solid; BACKGROUND-COLOR: #89a367 } TD.magazine_content { BORDER-RIGHT: #cccccc 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: = #cccccc 1px solid; PADDING-LEFT: 4px; FONT-SIZE: 11px; PADDING-BOTTOM: = 4px; VERTICAL-ALIGN: top; BORDER-LEFT: #cccccc 1px solid; WIDTH: 300px; = COLOR: #333333; PADDING-TOP: 4px; BORDER-BOTTOM: #cccccc 1px solid; = FONT-FAMILY: Arial,Helvetica,sans_serif } TD.research_content_header { PADDING-LEFT: 4px; BORDER-LEFT: #759db6 1px solid; WIDTH: 410px; = BORDER-BOTTOM: #759db6 1px solid; BACKGROUND-COLOR: #759db6 } TD.research_content { BORDER-RIGHT: #cccccc 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: = #cccccc 1px solid; PADDING-LEFT: 4px; FONT-SIZE: 11px; PADDING-BOTTOM: = 4px; VERTICAL-ALIGN: top; BORDER-LEFT: #cccccc 1px solid; WIDTH: 410px; = COLOR: #333333; PADDING-TOP: 4px; BORDER-BOTTOM: #cccccc 1px solid; = FONT-FAMILY: Arial,Helvetica,sans_serif } .cellplus_editorial { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 0px; MARGIN-LEFT: 10px; = BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; BORDER-BOTTOM: 0px; = BORDER-COLLAPSE: collapse } .cellplus_content_header { PADDING-LEFT: 4px; BORDER-LEFT: #cccccc 1px solid; WIDTH: 720px; = BORDER-BOTTOM: #cccccc 1px solid; BACKGROUND-COLOR: #cccccc } .cellplus_content { BORDER-RIGHT: #cccccc 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: = #cccccc 1px solid; PADDING-LEFT: 4px; FONT-SIZE: 11px; PADDING-BOTTOM: = 4px; BORDER-LEFT: #cccccc 1px solid; WIDTH: 730px; COLOR: #333333; = PADDING-TOP: 4px; BORDER-BOTTOM: #cccccc 1px solid; FONT-FAMILY: = Arial,Helvetica,sans_serif } .section_title_white { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #ffffff; FONT-FAMILY: = Arial,Helvetica,sans_serif } .section_title_black { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: = Arial,Helvetica,sans_serif } .corner_r_align_blue { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; VERTICAL-ALIGN: top; WIDTH: 10px; PADDING-TOP: 0px; BORDER-BOTTOM: = #000066 1px solid; BACKGROUND-COLOR: #000066; TEXT-ALIGN: right } .corner_r_align_grey { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; VERTICAL-ALIGN: top; WIDTH: 10px; PADDING-TOP: 0px; BORDER-BOTTOM: = #cccccc 1px solid; BACKGROUND-COLOR: #cccccc; TEXT-ALIGN: right } .corner_r_align_magazine { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; VERTICAL-ALIGN: top; WIDTH: 10px; PADDING-TOP: 0px; BORDER-BOTTOM: = #89a367 1px solid; BACKGROUND-COLOR: #89a367; TEXT-ALIGN: right } .corner_r_align_research { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; VERTICAL-ALIGN: top; WIDTH: 10px; PADDING-TOP: 0px; BORDER-BOTTOM: = #759db6 1px solid; BACKGROUND-COLOR: #759db6; TEXT-ALIGN: right } .cover_image_table { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 20px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .cover_image_table_top_right { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 0px; BORDER-LEFT: 0px; WIDTH: 634px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .cover_image_table_bottom_right { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 0px; BORDER-LEFT: 0px; WIDTH: 634px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .general_table_top { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 20px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .general_table_bottom { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } TD.cover_image { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: top; WIDTH: 96px; PADDING-TOP: 0px; TEXT-ALIGN: center } TD.descriptive_content { BORDER-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: 4px; VERTICAL-ALIGN: = top; BORDER-LEFT: 0px; WIDTH: 730px; BORDER-BOTTOM: 0px } TD.cover_image_content { BORDER-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: 4px; VERTICAL-ALIGN: = top; BORDER-LEFT: 0px; WIDTH: 414px; BORDER-BOTTOM: 0px } TD.cover_image_content_footer { BORDER-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: 4px; VERTICAL-ALIGN: = top; BORDER-LEFT: 0px; WIDTH: 634px; BORDER-BOTTOM: 0px } .cover_image_title { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Arial,Helvetica,sans_serif } TD.browse_archive { PADDING-LEFT: 4px; VERTICAL-ALIGN: top; WIDTH: 204px; TEXT-ALIGN: left } .cover_image_content IMG { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BORDER-LEFT: 0px; BORDER-BOTTOM: = 0px } P.archive_title { MARGIN-TOP: 0px; FONT-WEIGHT: bold; FONT-SIZE: 10px; MARGIN-BOTTOM: = 2px; COLOR: #333333; FONT-FAMILY: Arial,Helvetica,sans_serif } TD.quickjump { MARGIN-TOP: 0px; VERTICAL-ALIGN: top; PADDING-TOP: 0px } TD.quickjump IMG { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } .cover_caption_table { PADDING-RIGHT: 0px; MARGIN-TOP: 20px; PADDING-LEFT: 0px; MARGIN-BOTTOM: = 40px; PADDING-BOTTOM: 0px; MARGIN-LEFT: 10px; WIDTH: 730px; PADDING-TOP: = 0px; BORDER-BOTTOM: #cccccc 1px solid; BORDER-COLLAPSE: collapse } .cover_caption_header { PADDING-LEFT: 4px; WIDTH: 194px; BORDER-BOTTOM: #cccccc 1px solid; = HEIGHT: 16px; BACKGROUND-COLOR: #cccccc } .cover_caption_header_blank { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; PADDING-BOTTOM: 4px; WIDTH: = 430px; PADDING-TOP: 4px; BORDER-BOTTOM: #cccccc 1px solid; HEIGHT: 16px; = BACKGROUND-COLOR: #ffffff } TD.descriptive_content { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-SIZE: 11px; PADDING-BOTTOM: = 4px; COLOR: #333333; PADDING-TOP: 4px; FONT-FAMILY: = Arial,Helvetica,sans_serif } TD.cover_image_content { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-SIZE: 11px; PADDING-BOTTOM: = 4px; COLOR: #333333; PADDING-TOP: 4px; FONT-FAMILY: = Arial,Helvetica,sans_serif } TD.cover_image_content_footer { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-SIZE: 11px; PADDING-BOTTOM: = 4px; COLOR: #333333; PADDING-TOP: 4px; FONT-FAMILY: = Arial,Helvetica,sans_serif } TD.descriptive_content P { MARGIN-TOP: 10px; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 1.4em } TD.cover_image_content P { MARGIN-TOP: 10px; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 1.4em } TD.cellplus_content P { MARGIN-TOP: 10px; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 1.4em } TD.magazine_content P { MARGIN-TOP: 10px; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 1.4em } TD.research_content P { MARGIN-TOP: 10px; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 1.4em } TD.cover_image_content_footer P { MARGIN-TOP: 10px; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 1.4em } .content_header { FONT-WEIGHT: bold } TABLE.article_header { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 20px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } TABLE.article_main { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } H1.dochead_title { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica, sans_serif } H2.authors { FONT-WEIGHT: bold; FONT-SIZE: 15px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica, sans_serif } H4.content_header { MARGIN-TOP: 20px; FONT-WEIGHT: bold; FONT-SIZE: 14px; MARGIN-BOTTOM: = 4px; COLOR: #333333 } STRONG { FONT-WEIGHT: bold } A.correspondence { COLOR: #333333; TEXT-DECORATION: underline } TD.article_info { PADDING-RIGHT: 20px; PADDING-BOTTOM: 40px; VERTICAL-ALIGN: top; WIDTH: = 500px } TD.article_summary { VERTICAL-ALIGN: top; WIDTH: 720px } TD.article_summary_content { PADDING-RIGHT: 10px; VERTICAL-ALIGN: top; WIDTH: 720px } TD.article_content { PADDING-RIGHT: 10px; PADDING-BOTTOM: 30px; WIDTH: 720px } TD.article_info P { FONT-SIZE: 11px; COLOR: #333333; LINE-HEIGHT: 1.2em; FONT-FAMILY: = Verdana, Arial, Helvetica, sans_serif } TD.article_info P.affiliations { LINE-HEIGHT: 1.6em } TD.article_content P { FONT-SIZE: 1em; COLOR: #333333; LINE-HEIGHT: 1.2em; FONT-FAMILY: "Times = New Roman", Times, serif } TD.article_summary_content P { FONT-SIZE: 1em; COLOR: #333333; LINE-HEIGHT: 1.2em; FONT-FAMILY: "Times = New Roman", Times, serif } DIV.image_box { BORDER-RIGHT: #e5e5e5 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: = #e5e5e5 1px solid; PADDING-LEFT: 10px; MARGIN-BOTTOM: 20px; = PADDING-BOTTOM: 10px; BORDER-LEFT: #e5e5e5 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #e5e5e5 1px solid; BACKGROUND-COLOR: #f5f5f5 } DIV.image_box IMG { MARGIN-RIGHT: 1px } A.image_popwin { COLOR: #333333; TEXT-DECORATION: underline } A.image_popwin:hover { COLOR: #333333; TEXT-DECORATION: none } TD.article_options_vertical { VERTICAL-ALIGN: top; WIDTH: 200px; BACKGROUND-COLOR: #f5f5f5 } TABLE.article_options_menu { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; BORDER-COLLAPSE: collapse } .article_options_menu_subheader { PADDING-LEFT: 4px; WIDTH: 200px; BACKGROUND-COLOR: #e5e5e5 } TABLE.article_options_footer { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; MARGIN-TOP: = 10px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 20px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: 10px; BORDER-LEFT: 0px; WIDTH: 730px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px } TD.article_options_footer_cell1 { BORDER-RIGHT: #e5e5e5 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #e5e5e5 1px solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; = VERTICAL-ALIGN: top; BORDER-LEFT: #e5e5e5 1px solid; WIDTH: 320px; = PADDING-TOP: 2px; BORDER-BOTTOM: #e5e5e5 1px solid } TD.article_options_footer_cell2 { BORDER-RIGHT: #e5e5e5 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #e5e5e5 1px solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; = VERTICAL-ALIGN: top; BORDER-LEFT: #e5e5e5 1px solid; WIDTH: 200px; = PADDING-TOP: 2px; BORDER-BOTTOM: #e5e5e5 1px solid } TD.article_options_footer_cell3 { BORDER-RIGHT: #e5e5e5 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #e5e5e5 1px solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; = VERTICAL-ALIGN: top; BORDER-LEFT: #e5e5e5 1px solid; WIDTH: 200px; = PADDING-TOP: 2px; BORDER-BOTTOM: #e5e5e5 1px solid } .article_options_title { PADDING-LEFT: 4px; FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; = FONT-FAMILY: Arial,Helvetica,sans_serif } UL.article_options A:link { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #333333; FONT-FAMILY: = Arial,Helvetica,sans_serif; TEXT-DECORATION: underline } UL.article_options A:visited { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #333333; FONT-FAMILY: = Arial,Helvetica,sans_serif; TEXT-DECORATION: underline } UL.article_options A:hover { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: = Arial,Helvetica,sans_serif; TEXT-DECORATION: none } UL.article_lists LI A:link { FONT-SIZE: 10px; COLOR: #333333; FONT-FAMILY: = Arial,Helvetica,sans_serif; TEXT-DECORATION: none } UL.article_lists LI A:visited { FONT-SIZE: 10px; COLOR: #333333; FONT-FAMILY: = Arial,Helvetica,sans_serif; TEXT-DECORATION: none } UL.article_lists LI A:hover { TEXT-DECORATION: underline } UL.internal_nav { MARGIN-TOP: 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 15px; = PADDING-BOTTOM: 15px; MARGIN-LEFT: 0px; LIST-STYLE-TYPE: none } .internal_nav LI { DISPLAY: inline } UL.internal_nav LI A { BORDER-RIGHT: #e5e5e5 1px solid; BORDER-TOP: #e5e5e5 1px solid; = DISPLAY: block; PADDING-LEFT: 2px; FONT-SIZE: 10px; FLOAT: left; = BORDER-LEFT: #e5e5e5 1px solid; WIDTH: 70px; COLOR: #000000; = PADDING-TOP: 3px; BORDER-BOTTOM: #e5e5e5 1px solid; FONT-FAMILY: = Arial,Helvetica,sans_serif; HEIGHT: 20px; TEXT-DECORATION: none } UL.internal_nav LI A { BORDER-RIGHT: #e5e5e5 1px solid; BORDER-TOP: #e5e5e5 1px solid; = DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 10px; FLOAT: left; = BORDER-LEFT: #e5e5e5 1px solid; WIDTH: 70px; COLOR: #000000; = PADDING-TOP: 3px; BORDER-BOTTOM: #e5e5e5 1px solid; FONT-FAMILY: = Arial,Helvetica,sans_serif; HEIGHT: 14px; TEXT-ALIGN: center; = TEXT-DECORATION: none } UL.internal_nav LI A.wide { WIDTH: 105px } UL.internal_nav LI A.selected { BORDER-BOTTOM: #333333 2px solid } UL.internal_nav LI A.selected_wide { WIDTH: 115px; BORDER-BOTTOM: #333333 2px solid } UL.internal_nav LI A:hover { BACKGROUND-COLOR: #e5e5e5 } .yearlinkscell { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #ffffff; FONT-FAMILY: = Arial,Helvetica,sans_serif } .yearlinkscell A { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #ffffff; FONT-FAMILY: = Arial,Helvetica,sans_serif } .corner_r_align_blue { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; VERTICAL-ALIGN: top; WIDTH: 10px; PADDING-TOP: 0px; BORDER-BOTTOM: = #000066 1px solid; BACKGROUND-COLOR: #000066; TEXT-ALIGN: right } .section_title_white { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #ffffff; FONT-FAMILY: = Arial,Helvetica,sans_serif } .section_title_black { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: = Arial,Helvetica,sans_serif } .mediakit { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: 0px; MARGIN: 0px; = BORDER-LEFT: medium none; PADDING-TOP: 0px; BORDER-BOTTOM: medium none; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; HEIGHT: 100% } ------=_NextPart_000_000B_01C6768E.59148B30 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cancercell.org/webfiles/javascript/script.js function dropdown(list) { var item=3Dlist.options[list.selectedIndex].value; if (item !=3D "nowhere")=20 { top.location=3Ditem; } } =09 function openhelp() { window.open('/popup/help', 'helpwindow', = 'width=3D580,height=3D410,left=3D0,top=3D0,screenX=3D0,screenY=3D0,resiza= ble=3Dno,scrollbars=3Dyes'); self.name=3D"main"; } function opensearchhelp() { = window.open('/popup/help/Finding_Information.htm','helpwindow','width=3D5= 80,height=3D410,left=3D0,top=3D0,screenX=3D0,screenY=3D0,resizable=3Dno,s= crollbars=3Dyes'); self.name=3D"main"; } function statecodeselect(thisform, thislist, list1, list2, = countrycodefield, countrydescfield) { var theform =3D eval("document." + thisform); var thelist =3D eval("theform." + thislist); eval("theform." + list1 + ".selectedIndex=3D0"); eval("theform." + list2 + ".selectedIndex=3D0"); eval("theform.elements[\"" + countrycodefield + = "\"].value=3Dthelist.options[thelist.selectedIndex].text"); eval("theform.elements[\"" + countrydescfield + = "\"].value=3Dthelist.options[thelist.selectedIndex].text"); } function clearstates ( thisform, strControlNameRoot, strIdentifiers ) { eval ( "document." + thisform + "." + strControlNameRoot + = ".value=3D''" ); var colIdentifiers =3D strIdentifiers.split ( ";" ); for ( var iCounter =3D 0; iCounter < colIdentifiers.length; iCounter++ = ) eval ( "document." + thisform + "." + strControlNameRoot + "_" + = colIdentifiers[iCounter] + ".selectedIndex=3D0" ); } function finalstate ( thisform, strControlNameRoot, strSelectRef, = strIdentifiers ) { var strCountryID =3D eval ( "document." + thisform + "." + strSelectRef = + ".options[document." + thisform + "." + strSelectRef + = ".selectedIndex].value" ); if ( strIdentifiers.indexOf ( strCountryID ) =3D=3D -1 || strCountryID = =3D=3D "0") return; var strStateID =3D eval ( "document." + thisform + "." + = strControlNameRoot + "_" + strCountryID + ".options[document." + = thisform + "." + strControlNameRoot + "_" + strCountryID + = ".selectedIndex].value" ); eval ( "document." + thisform + "." + strControlNameRoot ).value =3D = strStateID; } function setstate ( thisform, strControlNameRoot, strIdentifier, = strSelectRef, strIdentifiers, evt ) { // The following line ensures that the event type can be picked up = across all IE and NN var eventType =3D evt.type || arguments.callee.caller.name || = window.event.type; if ( eventType.indexOf ( "on" ) !=3D 0 ) eventType =3D "on" + eventType; if ( strIdentifier !=3D "" ) { if ( eval ( "document." + thisform + "." + strSelectRef + = ".options[document." + thisform + "." + strSelectRef + = ".selectedIndex].value" ) !=3D strIdentifier ) { // This part will be hit if the user selects a drop down that isn't = the one that they should // The country has not been set, or is set to something other than = the state box that was selected // Need to do two things. Set the country to the relevant value and = clear the other boxes if ( eventType =3D=3D "onchange" ) { // First, clear the other drop downs' values var colIdentifiers =3D strIdentifiers.split ( ";" ); for ( var iCounter =3D 0; iCounter < colIdentifiers.length; = iCounter++ ) { if ( colIdentifiers[iCounter] !=3D strIdentifier ) eval ( "document." + thisform + "." + strControlNameRoot + "_" + = colIdentifiers[iCounter] + ".selectedIndex=3D0" ); } // Clear the text box eval ( "document." + thisform + "." + strControlNameRoot + = ".value=3D''" ); // Now set the country eval ( "document." + thisform + "." + strSelectRef + ".selectedIndex = =3D " + searchArray ( eval ( "document." + thisform + "." + strSelectRef = + ".options" ), strIdentifier ) ); } return; } return; } else { if ( ( eval ( "document." + thisform + "." + strSelectRef + = ".selectedIndex" ) =3D=3D 0 ) || ( eval ( "document." + thisform + "." + strSelectRef + = ".options[document." + thisform + "." + strSelectRef + = ".selectedIndex].value" ) =3D=3D 1224 ) || ( eval ( "document." + thisform + "." + strSelectRef + = ".options[document." + thisform + "." + strSelectRef + = ".selectedIndex].value" ) =3D=3D 1037 ) ) { // This part will be entered when the user selects the text box and = that doesn't match what's in the country box // What needs to be done is the country box is aligned and the other = state input boxes to be reset if ( eventType =3D=3D "onchange" ) { // First, clear the drop downs' values var colIdentifiers =3D strIdentifiers.split ( ";" ); for ( var iCounter =3D 0; iCounter < colIdentifiers.length; = iCounter++ ) eval ( "document." + thisform + "." + strControlNameRoot + "_" + = colIdentifiers[iCounter] + ".selectedIndex=3D0" ); // Now set the country // Should we set it to a country? Or should it be blank? Think it = should be set to blank. eval ( "document." + thisform + "." + strSelectRef + ".selectedIndex = =3D 0" ); } return; } return; } } // This function searches an array and returns the index at which the = search string occurs function searchArray ( arrToSearch, strSearchValue ) { for ( var iCounter =3D 0; iCounter < arrToSearch.length; iCounter++ ) if ( arrToSearch[iCounter].value =3D=3D strSearchValue ) return iCounter; return -1; } function sethidden(value,field,value2) { if(!value2) { if(field.options) value2=3Dfield.options[field.selectedIndex].value; else value2=3Dfield.value; } if(value2!=3D"") { field.form.elements[value].value=3Dvalue2; } } function setEcommerce2Hidden() { sethidden('titleid',orderdetails.addresstitleid); sethidden('firstname',orderdetails.addressfirstname); sethidden('lastname',orderdetails.addresslastname); sethidden('address1',orderdetails.addressstreet); sethidden('address2',orderdetails.addressstreet2); sethidden('city',orderdetails.addresscity); sethidden('state',orderdetails.addressstate); sethidden('countryid',orderdetails.addresscountry); sethidden('zip',orderdetails.addresspostcode); sethidden('telephone',orderdetails.addressphone); } // Logic for YOAS checkboxs function yoasValidate(ckb) { var cnt =3D document.journals.journal.length - 3; var bk =3D document.journals.backfile.length >=3D 3; =09 if (bk) { //alert("records " + cnt); for (j =3D cnt; j < (cnt+3); j++)=20 { if (eval("document.journals.journal[" + (j) + "].checked") =3D=3D = true)=20 { document.journals.journal[j].checked =3D false; if (j - cnt =3D=3D ckb - 1)=20 { document.journals.journal[j].checked =3D true; } } } } } function noCheckbox() { for (j =3D 0; j < checkbox_form.uid.length; j++) { =20 if (checkbox_form.uid[j].checked) {=20 return true;=20 } =20 } msg =3D "Please select at least one checkbox"; alert(msg); return (false); } function encode(string){ =20 return string; } ------=_NextPart_000_000B_01C6768E.59148B30--