From: Subject: ::: JBM ::: Date: Sat, 20 May 2006 09:43:49 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0018_01C67BF1.E55A4130" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0018_01C67BF1.E55A4130 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.biological-markers.com/index.asp?a=abstract&id=E2CDF327-4CCC-4A18-A5A3-3667C5D ::: JBM :::
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Int J Biol Markers 2006; 21: 50 = -=20 57
Association of TP53 mutation, p53=20 overexpression, and p53 codon 72 polymorphism with=20 susceptibility to apoptosis in adult patients with = diffuse=20 astrocytomas
M. Uno1, S.M. Oba-Shinjo1, A.=20 Wakamatsu2, N. Huang1, V. = Avancini=20 Ferreira Alves2, S. Rosemberg2, = P.H.=20 Pires de Aguiar1, C. Leite3, F.=20 Miura1, R. Marino J.1, M.=20 Scaff1, S.K.=20 = Nagahashi-Marie1


1Department of Neurology, School of = Medicine,=20 University of S=E3o Paulo, S=E3o Paulo -=20 Brazil
2Department of Pathology, School of = Medicine,=20 University of S=E3o Paulo, S=E3o Paulo -=20 Brazil
3Department of Radiology, School of = Medicine,=20 University of S=E3o Paulo, S=E3o Paulo -=20 Brazil

ABSTRACT
Clarification of TP53 alterations is = important=20 to understand the mechanisms underlying the = development of=20 diffuse astrocytomas. It has been suggested that the = alleles=20 of TP53 at codon 72 differ in their ability to induce=20 apoptosis in human cancers. The aim of this study was = to=20 analyze the possible association of TP53 mutation, p53 = overexpression, and p53 codon 72 polymorphism with=20 susceptibility to apoptosis in adult Brazilian = patients with=20 diffuse astrocytomas. We analyzed 56 surgical = specimens of=20 diffuse astrocytomas for alterations of TP53, using = polymerase=20 chain reaction single-strand conformation polymorphism = (PCR-SSCP) direct sequencing. p53 and cleaved caspase = 3=20 protein expression were assessed by = immunohistochemistry. We=20 found TP53 mutations in 19.6% (11 out of 56) of tumors = tested,=20 with the lowest mutation rate found in the cases of=20 glioblastomas (8.8%) (p =3D 0.03). Only 16.1% of = tumors tested=20 showed cleaved caspase 3-positive staining, = demonstrating that=20 apoptosis is very inhibited in these tumors. All = tumors having=20 TP53 mutation and p53 accumulation had no expression = of=20 cleaved caspase 3. Additionally, no association was = observed=20 in tumors having proline and arginine alleles and = expression=20 of cleaved caspase 3. We concluded that clarification = of the=20 TP53 alterations allows a better understanding of the=20 mechanisms involved in the progression of diffuse=20 astrocytomas, and the allele status at codon 72 was = not=20 associated with apoptosis in these = tumors.

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The International Journal of = Biological=20 Markers is published and copyrighted by Wichtig = Editore -=20 Milano (Italy)
Reg. Trib. di Milano n. 372 del 20.07.1985 = -=20 Direttore Responsabile Diego Brancaccio - ISSN=20 = 1724-6008
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modifica la dimensione x = della finestra da aprire=20 yDim =3D yDim+16; // se il S.O. =E8 MAC modifica la dimensione = y della finestra da aprire=20 } } var xCrd =3D screen.availWidth; // trova la dimensione x dello = schermo=20 var yCrd =3D screen.availHeight; // trova la dimensione y dello = schermo=20 xCrd =3D (xCrd-xDim)/2; // calcola la coordinata x per il = posizionamento della finestra a centro schermo in base ai precedenti = valori (dimensione x finestrella e dimensione x dello schermo)=20 yCrd =3D (yCrd-yDim)/2; // calcola la coordinata y per il = posizionamento della finestra a centro schermo in base ai precedenti = valori (dimensione y finestrella e dimensione y dello schermo)=20 var nuovaFinestra =3D window.open(indirizzo, "nuovaFinestra", = "menubar=3D0,titlebar=3D0,toolbar=3D0,location=3D0,directories=3D0,status= =3D0,scrollbars=3D0,resizable=3D0,copyhistory=3D0,Width=3D"+xDim+",Height= =3D"+yDim+",screenX=3D"+xCrd+",screenY=3D"+yCrd); // apre fisicamente la = nuova finestra con tutto una serie di parametri facilmente = riconoscibili; allo 0 puoi sostituire no oppure mettere 1 o yes se la = vuoi attivare - ti baster=E0 fare alcune prove per capire come funziona = il tutto.=20 if (browser=3D=3D"Microsoft") {nuovaFinestra.moveTo(xCrd,yCrd); = } // se il browser =E8 IE sposta la finestrella appena aperta alle = coordinate calcolate in precedenza=20 nuovaFinestra.location.href =3D indirizzo; // carica nella = finestrella appena aperta il file specificato } =09 ------=_NextPart_000_0018_01C67BF1.E55A4130 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://ads.wichtig-online-services.com/adx.js function phpads_deliverActiveX(content)=0A= {=0A= document.write(content); =0A= } ------=_NextPart_000_0018_01C67BF1.E55A4130--