From: Subject: Cancer Cell -- Calabrese et al. Date: Sun, 21 Jan 2007 13:38:18 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_003A_01C73D61.68C23AB0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3028 This is a multi-part message in MIME format. ------=_NextPart_000_003A_01C73D61.68C23AB0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cancercell.org/content/article/abstract?uid=PIIS1535610806003692 =EF=BB=BF Cancer Cell -- Calabrese et = al. =

Copyright =C2=A9 2007 Cell Press. All rights=20 reserved.
Cancer Cell, Vol 11, 69-82, January 2007

Article

A = Perivascular=20 Niche for Brain Tumor Stem Cells

Christopher Calabrese,1 = Helen Poppleton,1 Mehmet Kocak,2 Twala L. Hogg,1 = Christine Fuller,3 Blair Hamner,4 Eun Young Oh,1 M. = Waleed Gaber,5 = David Finklestein,6 = Meredith Allen,1 Adrian Frank,1 Ildar = T. Bayazitov,1 Stanislav = S. Zakharenko,1 Amar Gajjar,7 = Andrew Davidoff,4 and Richard=20 J. Gilbertson1,7,

1 Department = of=20 Developmental Neurobiology, St. Jude Children's Research Hospital, 332 = North=20 Lauderdale Street, Memphis, TN 38105, USA2 Department = of=20 Biostatistics, St. Jude Children's Research Hospital, 332 North = Lauderdale=20 Street, Memphis, TN 38105, USA3 Department = of=20 Pathology, St. Jude Children's Research Hospital, 332 North Lauderdale = Street,=20 Memphis, TN 38105, USA4 Department = of Surgery,=20 St. Jude Children's Research Hospital, 332 North Lauderdale Street, = Memphis, TN=20 38105, USA
5 Department = of=20 Radiation Oncology, St. Jude Children's Research Hospital, 332 North = Lauderdale=20 Street, Memphis, TN 38105, USA6 The = Hartwell Center=20 for Bioinformatics and Biotechnology, St. Jude Children's Research = Hospital, 332=20 North Lauderdale Street, Memphis, TN 38105, USA7 Department = of=20 Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale = Street,=20 Memphis, TN 38105, USA

Corresponding author
Richard J. Gilbertson
richard.gilbertson@stjude.o= rg


Summary


Cancers are believed to arise = from=20 cancer stem cells (CSCs), but it is not known if these cells remain = dependent=20 upon the niche microenvironments that regulate normal stem cells. We = show that=20 endothelial cells interact closely with self-renewing brain tumor cells = and=20 secrete factors that maintain these cells in a stem cell-like state. = Increasing=20 the number of endothelial cells or blood vessels in orthotopic brain = tumor=20 xenografts expanded the fraction of self-renewing cells and accelerated = the=20 initiation and growth of tumors. Conversely, depletion of blood vessels = from=20 xenografts ablated self-renewing cells from tumors and arrested tumor = growth. We=20 propose that brain CSCs are maintained within vascular niches that are = important=20 targets for therapeutic approaches.

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