From: Subject: microRNAs join the p53 network [mdash] another piece in the tumour-suppression puzzle : Abstract : Nature Reviews Cancer Date: Fri, 9 May 2008 18:37:39 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_00B6_01C8B203.C251B5C0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_00B6_01C8B203.C251B5C0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nrc/journal/v7/n11/abs/nrc2232.html microRNAs join the = p53 network [mdash] another piece in the tumour-suppression puzzle : = Abstract : Nature Reviews Cancer

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Nature Reviews Cancer = 7, 819-822 = (November 2007) | = doi:10.1038/nrc2232

microRNAs join the p53 network =97 another piece in the=20 tumour-suppression puzzle

Lin He1,=20 Xingyue He1,2,=20 Scott W. Lowe1=20 & Gregory J. Hannon1 =20 Ab= out the=20 authors

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Abstract

Several recent studies have found a conserved microRNA = (miRNA)=20 family, the miR-34s, to be direct transcriptional targets of p53. miR-34 = activation can recapitulate elements of p53 activity, including = induction of=20 cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can = impair=20 p53-mediated cell death. These data reinforce the growing awareness that = non-coding RNAs are key players in tumour development by placing miRNAs = in a=20 central role in a well-known tumour-suppressor network.

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Author affiliations

  1. Lin He, Xingyue He, Scott W. Lowe and Gregory J. Hannon = are at the=20 Watson School of Biological Sciences, Howard Hughes Medical Institute, = Cold=20 Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New = York 11724,=20 USA.
  2. Xingyue He is at the Program in Genetics, Stony Brook = University,=20 Stony Brook, New York 11794, USA.

Correspondence to: Gregory J. Hannon1=20 Email: hannon@cshl.edu =

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solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #foot-er #footer-links UL LI A:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } * HTML #foot-er #footer-links UL LI A:link { DISPLAY: inline } * HTML #foot-er #footer-links UL LI A:visited { DISPLAY: inline } #foot-er #footer-links UL LI A:hover { TEXT-DECORATION: underline } #foot-er #footer-links UL LI A.about-npg:link { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-links UL LI A.about-npg:visited { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-copyright { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left! important } * HTML #foot-er #footer-copyright .footer-constrain 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