From: Subject: Impaired microRNA processing enhances cellular transformation and tumorigenesis : Abstract : Nature Genetics Date: Thu, 8 May 2008 13:46:05 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_017E_01C8B111.DCADD7C0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_017E_01C8B111.DCADD7C0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/ng/journal/v39/n5/abs/ng2003.html Impaired microRNA = processing enhances cellular transformation and tumorigenesis : Abstract = : Nature Genetics

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Letter abstract

Nature Genetics 39, 673 - 677 (2007)
Published online: 1 April 2007 = | doi:10.1038/ng2003

Impaired microRNA processing enhances cellular = transformation and=20 tumorigenesis

Madhu S Kumar1= ,=20 Jun Lu2= ,3= ,=20 Kim L Mercer1= ,=20 Todd R Golub2= ,3= ,4= =20 & Tyler Jacks1= ,5=

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MicroRNAs (miRNAs) are a new class of small noncoding = RNAs that=20 post-transcriptionally regulate the expression of target mRNA = transcripts. Many=20 of these target mRNA transcripts are involved in proliferation, = differentiation=20 and apoptosis1,=20 2,=20 processes commonly altered during tumorigenesis. Recent work has shown a = global=20 decrease of mature miRNA expression in human cancers3.=20 However, it is unclear whether this global repression of miRNAs reflects = the=20 undifferentiated state of tumors or causally contributes to the = transformed=20 phenotype. Here we show that global repression of miRNA maturation = promotes=20 cellular transformation and tumorigenesis. Cancer cells expressing short = hairpin=20 RNAs (shRNAs) targeting three different components of the miRNA = processing=20 machinery showed a substantial decrease in steady-state miRNA levels and = a more=20 pronounced transformed phenotype. In animals, miRNA = processing=96impaired cells=20 formed tumors with accelerated kinetics. These tumors were more invasive = than=20 control tumors, suggesting that global miRNA loss enhances = tumorigenesis.=20 Furthermore, conditional deletion of Dicer1 enhanced tumor = development in=20 a K-Ras=96induced mouse model of lung cancer. Overall, these studies = indicate that=20 abrogation of global miRNA processing promotes = tumorigenesis.

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  1. MIT Center for Cancer Research, Cambridge, Massachusetts = 02139, USA.
  2. Broad Institute of MIT and Harvard, Cambridge, = Massachusetts 02141,=20 USA.
  3. Department of Pediatric Oncology, Dana-Farber Cancer = Institute and=20 Harvard Medical School, Boston, Massachusetts 02115, USA.
  4. Howard Hughes Medical Institute, Harvard Medical School, = Boston,=20 Massachusetts 02115, USA.
  5. Howard Hughes Medical Institute, Department of Biology,=20 Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, = USA.

Correspondence to: Tyler Jacks1= ,5= =20 e-mail: tjacks@mit.edu =

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} SPAN.page-header-spacer { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140%; VISIBILITY: hidden; = PADDING-BOTTOM: 4px; MARGIN: 15px 0px 0px } SPAN.booktitle { FONT-STYLE: italic } SPAN.journalname { FONT-STYLE: italic } SPAN.journalnumber { FONT-WEIGHT: bold } SPAN.tm { VERTICAL-ALIGN: super } LEGEND { COLOR: #000 } * HTML #breadcrumb DIV { MARGIN-TOP: 0px; PADDING-LEFT: 5px; PADDING-TOP: 1px } #breadcrumb DIV { CLEAR: left; MARGIN-TOP: 0px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 10px; PADDING-TOP: 1px } #breadcrumb DIV A:link { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:visited { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:hover { COLOR: #000; TEXT-DECORATION: underline } #breadcrumb SPAN.divider { FONT-SIZE: 70%; COLOR: #000 } #breadcrumb SPAN.thisitem { FONT-SIZE: 70%; COLOR: #000 } #login-inpage { MARGIN: 0px; COLOR: #000; BACKGROUND-COLOR: #eaeaea } #login-inpage A { FONT-SIZE: 70% } #login-inpage DIV.userpassbox { FLOAT: left; WIDTH: 8em } #login-inpage .passdetails { CLEAR: left } #login-inpage INPUT.text { FONT-SIZE: 80%; MARGIN: 0px; WIDTH: 9em; COLOR: #000 } #login-inpage LABEL { FONT-SIZE: 70% } #login-inpage INPUT.button { MARGIN-TOP: 5px } #login-inpage #savepass-inpage { MARGIN-BOTTOM: -2px } #login-inpage DIV.error { PADDING-LEFT: 20px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/login_error.gif) no-repeat 0px 4px; MARGIN-BOTTOM: = 5px; COLOR: #c30 } #login-inpage DIV.error SPAN { FONT-WEIGHT: bold } #head-er HR { DISPLAY: none } #head-er .header-nonad-wrapper { PADDING-BOTTOM: 15px; BORDER-BOTTOM: #fff 1px solid } #head-er .accessibility-login-wrap { FLOAT: left; WIDTH: 100%; BORDER-BOTTOM: #000 1px solid; = BACKGROUND-COLOR: #eaeaea } #head-er .accessibility-login { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 4px; TEXT-ALIGN: right } #head-er .accessibility-login A.nature-link { FLOAT: left; FONT: bold 160%/80% Garamond, serif; WIDTH: 4.9em; COLOR: = #b1062e; MARGIN-RIGHT: 20px; TEXT-ALIGN: left; TEXT-DECORATION: none } * HTML #head-er .accessibility-login A.nature-link:hover { BACKGROUND: none transparent scroll repeat 0% 0% } #head-er .accessibility-login A.nature-link:hover { BACKGROUND: = url(/common/includes/header/images/nature.com.underline.gif) no-repeat = left bottom } #head-er .accessibility-login IMG.nature-logo { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 1px 20px 0px 0px; WIDTH: 82px! = important; HEIGHT: 11px; BORDER-RIGHT-WIDTH: 0px } #head-er .accessibility-login .jumplinks { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 45%; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } #head-er .accessibility-login .jumplinks LI { DISPLAY: inline; PADDING-LEFT: 15px } #head-er .accessibility-login .jumplinks LI.first { PADDING-LEFT: 0px } #head-er .accessibility-login .jumplinks A { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/b1062e/arrow_down.gif) no-repeat left center; = COLOR: #000; TEXT-DECORATION: none } #head-er .accessibility-login .jumplinks A:hover { TEXT-DECORATION: underline } #head-er DIV.logon { =09 } #head-er .logon .onlyformacie { FONT-SIZE: 3px } #head-er .logon .onlyformacie { DISPLAY: none } #head-er .logon A.login { PADDING-RIGHT: 15px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logon.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon A.login:hover { BACKGROUND: url(/common/includes/header/images/logon_over.gif) = no-repeat right center; TEXT-DECORATION: underline } #head-er .logon A.login:active { BACKGROUND: url(/common/includes/header/images/logon.gif) no-repeat = right center } #head-er .logon A.logoff { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logoff.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon P { MARGIN: 0px } #head-er .logon .user { FONT-WEIGHT: bold } #head-er .logon .inst { FONT-WEIGHT: bold } #head-er .image-user-services-wrap { FLOAT: left; WIDTH: 100%; BACKGROUND-COLOR: #d6335c } #head-er .image-user-services { BORDER-BOTTOM: transparent 1px solid } * HTML #head-er .image-user-services { BORDER-BOTTOM-WIDTH: 0px } #head-er .image-user-services IMG.journal-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; WIDTH: 344px; HEIGHT: 74px; = BORDER-RIGHT-WIDTH: 0px } #head-er .user-services { FLOAT: right } #head-er .div1.user-services { WIDTH: 12.35em! important } #head-er .div2.user-services { WIDTH: 8.7em! important } #head-er .user-services UL { BORDER-RIGHT: #fff 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: #fff 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 22px 0px 21px; = BORDER-LEFT: #fff 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 0px = solid; LIST-STYLE-TYPE: none; TEXT-ALIGN: right } #head-er .user-services UL.list1 { BORDER-RIGHT: #fff 1px solid } #head-er .user-services LI { BORDER-BOTTOM: #fff 1px solid } #head-er .user-services A { PADDING-RIGHT: 13px; DISPLAY: block; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) #767474 no-repeat right = center; PADDING-BOTTOM: 1px; TEXT-TRANSFORM: uppercase; COLOR: #fff; = PADDING-TOP: 1px; TEXT-DECORATION: none } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .publications-search-wrap { BACKGROUND: #000 } * HTML #head-er .publications-search { PADDING-BOTTOM: 3px; PADDING-TOP: 3px } #head-er .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 4px; = PADDING-TOP: 4px } * HTML #head-er .publications { MARGIN: 6px 0px 0px } #head-er .publications { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4px 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #head-er .publications LI { DISPLAY: inline; MARGIN-LEFT: 10px } #head-er .publications LI.first { MARGIN-LEFT: 0px } #head-er .publications A { PADDING-RIGHT: 15px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .publications A:hover { TEXT-DECORATION: underline } #head-er .search { TEXT-ALIGN: right } #head-er .search FORM { DISPLAY: inline; MARGIN: 0px } #head-er .search FORM A { PADDING-RIGHT: 14px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .search FORM A:hover { TEXT-DECORATION: underline } #head-er #searchtext { WIDTH: 10em } #head-er .publications-search LABEL { TEXT-TRANSFORM: uppercase; COLOR: #fff } #head-er INPUT { FONT-SIZE: 100% } #head-er SELECT { FONT-SIZE: 100% } #head-er .publications-search INPUT.button { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px } #head-er .accessibility-login { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .image-user-services { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .publications-search { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } .header-leaderboard-wrap { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: = url(/common/includes/header/images/bg_leaderboard.gif) no-repeat 50% = 0px; OVERFLOW: hidden } .header-leaderboard { MAX-HEIGHT: 105px; TEXT-ALIGN: center } * HTML .header-leaderboard IMG { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard ilayer { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard IFRAME { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard EMBED { BORDER-BOTTOM-WIDTH: 1px } .header-leaderboard IMG { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard ilayer { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard IFRAME { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard EMBED { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard TABLE { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MAX-WIDTH: 728px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: auto; WIDTH: 100%; MARGIN-RIGHT: auto; PADDING-TOP: 0px; = BORDER-BOTTOM: #fff 1px solid; BORDER-RIGHT-WIDTH: 0px } * HTML .header-leaderboard TABLE IMG { HEIGHT: auto } #constrain { MARGIN-TOP: 14px } #global-subject-areas { BORDER-RIGHT: #ebebeb 1px solid; BORDER-TOP: #ebebeb 1px solid; = BACKGROUND: #ebebeb; MARGIN: 0px 0px 20px; BORDER-LEFT: #ebebeb 1px = solid; BORDER-BOTTOM: #ebebeb 1px solid } #global-subject-areas ABBR { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px; TEXT-DECORATION: none } #global-subject-areas A:link { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:visited { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:hover { TEXT-DECORATION: underline } #global-subject-areas H2 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #global-subject-areas UL UL { FONT-SIZE: 100% } #global-subject-areas UL LI { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = LINE-HEIGHT: 150%; PADDING-TOP: 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL LI LI { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #global-subject-areas UL LI H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H5 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H6 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav { DISPLAY: block; MARGIN-BOTTOM: 20px } MAP.journal-nav UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } MAP.journal-nav UL LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } MAP.journal-nav UL LI.grouped { BORDER-BOTTOM: #eaeaea 1px solid } * HTML MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } * HTML MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:hover { COLOR: #fff; BACKGROUND-COLOR: #c00; TEXT-DECORATION: none } MAP.journal-nav UL LI A.on { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.on:visited { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.submission { PADDING-LEFT: 20px! important; BACKGROUND: = url(/common/images/online_submissions.gif) no-repeat left center } MAP.journal-nav UL LI UL.subnav { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } MAP.journal-nav UL LI UL.subnav LI { BACKGROUND: url(/common/images/nav_dots2.gif) #fafafa no-repeat 11px = 5px; BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px } MAP.journal-nav UL LI UL.subnav LI.on { BACKGROUND: url(/common/images/nav_dots1.gif) #c00 no-repeat 11px 5px; = BORDER-BOTTOM: #fafafa 1px solid } * HTML MAP.journal-nav UL LI UL.subnav A { PADDING-RIGHT: 10px! important; PADDING-LEFT: 20px! important; = PADDING-BOTTOM: 2px! important; PADDING-TOP: 2px! important } MAP.journal-nav UL LI UL.subnav A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:hover { BACKGROUND: url(/common/images/nav_dots1.gif) #fab934 no-repeat 11px = 5px; COLOR: #fff; TEXT-DECORATION: none } MAP.journal-nav UL LI 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= PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-plugins { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { BORDER-BOTTOM-WIDTH: 0px } #article-related DIV.wrapper { MARGIN-BOTTOM: 10px } #article-related P.explain { FONT-SIZE: 70%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P.last { MARGIN: 0px } #article-related P.results { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related A.article { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article-related P.journal { FONT-SIZE: 70%; MARGIN: 0px } #article-related DIV.container-more2 P.journal { MARGIN-BOTTOM: 1em } #article-related H3.area { FONT-WEIGHT: normal; FONT-SIZE: 70%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase } #article-related A.allmatches:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related A.allmatches:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related A.allmatches:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat left center } #article-related DIV.text { FLOAT: left; WIDTH: 210px; TEXT-ALIGN: right } #article-related DIV.text LABEL { FONT-WEIGHT: bold; FONT-SIZE: 90% } #article-related DIV.text P { FONT-SIZE: 70%; MARGIN: 0px } #article-related DIV.form { MARGIN-LEFT: 220px } #article-related DIV.form INPUT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.form TEXTAREA { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.form INPUT { WIDTH: 100% } #article-related DIV.form TEXTAREA { WIDTH: 100% } #article-related INPUT.friend { CLEAR: both; FLOAT: right } * HTML #article-related TABLE.data { FONT-SIZE: 100% } #article-related TABLE.data { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: = #999 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #999 1px solid; = BORDER-COLLAPSE: collapse; TEXT-ALIGN: left } #article-related TABLE.data THEAD { FONT-WEIGHT: bold } #article-related TABLE.data THEAD TH { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0.5em; PADDING-LEFT: = 0.5em; FONT-SIZE: 90%; BACKGROUND: #f6f6f6; PADDING-BOTTOM: 0.5em; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 0px } #article-related TABLE.data THEAD TH.colspan { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 0px solid; BORDER-LEFT: = #999 1px solid; BORDER-BOTTOM: #999 1px solid; TEXT-ALIGN: center } #article-related TABLE.data THEAD TH.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.rowsep { 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#footer-journal:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #foot-er #footer-journal { HEIGHT: 1% } #foot-er #footer-journal P { PADDING-RIGHT: 1em; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 1em 0px 0px; PADDING-TOP: 0px } #foot-er #footer-journal P.journal-name { FONT-WEIGHT: bold; FONT-SIZE: 100%; FONT-STYLE: italic } #foot-er #footer-journal P.issn { FONT-SIZE: 100% } #foot-er #footer-journal P.eissn { FONT-SIZE: 100% } #foot-er #footer-journal P.extra { FONT-SIZE: 100% } #foot-er #footer-links { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: #000; PADDING-BOTTOM: = 5px; PADDING-TOP: 5px } #foot-er #footer-links UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #foot-er #footer-links UL LI { DISPLAY: inline } #foot-er #footer-links UL LI A:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #foot-er #footer-links UL LI A:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } * HTML #foot-er #footer-links UL LI A:link { DISPLAY: inline } * HTML #foot-er #footer-links UL LI A:visited { DISPLAY: inline } #foot-er #footer-links UL LI A:hover { TEXT-DECORATION: underline } #foot-er #footer-links UL LI A.about-npg:link { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-links UL LI A.about-npg:visited { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-copyright { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left! important } * HTML #foot-er #footer-copyright .footer-constrain { TEXT-ALIGN: left } #foot-er #footer-copyright A { COLOR: #b1062e } #foot-er #footer-copyright P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 5px } #foot-er #footer-copyright P.logo { PADDING-RIGHT: 36px; PADDING-LEFT: 36px; BACKGROUND: = url(/common/images/npg_logo.gif) no-repeat 0px 50%; PADDING-BOTTOM: 7px; = MARGIN: 5px 0px 0px; PADDING-TOP: 7px } #foot-er #footer-copyright P A:link { FONT-WEIGHT: bold; TEXT-DECORATION: none } #foot-er #footer-copyright P A:visited { FONT-WEIGHT: bold; TEXT-DECORATION: none } #foot-er #footer-copyright P A.footer-copyright:link { FONT-WEIGHT: normal; COLOR: #000 } #foot-er #footer-copyright P A.footer-copyright:visited { FONT-WEIGHT: normal; COLOR: #000 } #foot-er #footer-copyright P A:hover { TEXT-DECORATION: underline } #content .scp { FONT-VARIANT: small-caps } DIV.ab-ad { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; BACKGROUND: #eaeaea; = MARGIN-BOTTOM: 15px; PADDING-BOTTOM: 3px; PADDING-TOP: 0px; TEXT-ALIGN: = center } DIV.ab-ad H2.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H4.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H5.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H6.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad H6.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad DIV.container { BORDER-RIGHT: #e0ebf9 1px solid; BORDER-TOP: #e0ebf9 1px solid; = MARGIN-TOP: 3px; BORDER-LEFT: #e0ebf9 1px solid; BORDER-BOTTOM: #e0ebf9 = 1px solid; BACKGROUND-COLOR: #fff } DIV.ab-ad UL { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 5px; MARGIN: 0px; TEXT-TRANSFORM: none; PADDING-TOP: = 5px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } DIV.ab-ad UL UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } DIV.ab-ad LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: = 0px; PADDING-TOP: 2px } DIV.ab-ad A { COLOR: #0068b3 } DIV.ab-ad A.sponsor IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 118px; WIDTH: 100%; BORDER-RIGHT-WIDTH: 0px } DIV.ab-ad P.blurb { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 5px 5px; PADDING-TOP: 0px; TEXT-ALIGN: left } .eotm-jotw { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: 0px = 0px 20px; OVERFLOW: hidden; BORDER-LEFT: #e7e7e7 1px solid; PADDING-TOP: = 0px; BORDER-BOTTOM: #e7e7e7 1px solid; LIST-STYLE-TYPE: none; = BACKGROUND-COLOR: #fff } .eotm-jotw .main-heading { PADDING-RIGHT: 10px; PADDING-LEFT: 48px; FONT-SIZE: 110%; BACKGROUND: = url(/common/images/eotm_jotw_bg.jpg) no-repeat 0px 0px; 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} A.fulltext { FONT-WEIGHT: bold } #content SPAN.free-access { FONT-SIZE: 80%; TEXT-TRANSFORM: uppercase; COLOR: #c03 } UL.anchor { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; PADDING-BOTTOM: = 0px; MARGIN: 1em 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.anchor A:link { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/309/arrow_light_down.gif) no-repeat 0px 0.5em } UL.anchor A:visited { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/309/arrow_light_down.gif) no-repeat 0px 0.5em } UL.anchor A:hover { BACKGROUND: url(/common/images/icons/c03/arrow_down.gif) no-repeat 0px = 0.5em } UL.anchor A.out:link { BACKGROUND: url(/common/images/icons/309/arrow_light.gif) no-repeat 0px = 0.5em } UL.anchor A.out:visited { BACKGROUND: url(/common/images/icons/309/arrow_light.gif) no-repeat 0px = 0.5em } UL.anchor A.out:hover { BACKGROUND: url(/common/images/icons/c03/arrow.gif) no-repeat 0px 0.5em } #content UL.anchor UL { LIST-STYLE-TYPE: none } UNKNOWN { BACKGROUND: #fffddd } #content P.support-note { FONT-SIZE: 80%; MARGIN: 0px; COLOR: #666 } * HTML #content TABLE.data { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content TABLE.data { CLEAR: both; BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #999 1px solid; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px = solid } #content TABLE.data TD { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } #content TABLE.data TH { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } * HTML #content TABLE.data CAPTION { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; = PADDING-TOP: 0px } * HTML #content TABLE.data CAPTION { FONT-SIZE: 90% } #content TABLE.data CAPTION { PADDING-RIGHT: 0px; PADDING-LEFT: 20px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; PADDING-BOTTOM: 5px; MARGIN: 1em 0px 0px; PADDING-TOP: 0px; = TEXT-ALIGN: left } * HTML #content TABLE.data THEAD TH { BORDER-TOP-WIDTH: 0px } * HTML #content TABLE.data THEAD TD { BORDER-TOP-WIDTH: 0px } #content TABLE.data THEAD TH { BORDER-TOP: #d6d6d6 1px solid; BORDER-BOTTOM: #d6d6d6 1px solid } #content TABLE.data THEAD TD { BORDER-TOP: #d6d6d6 1px solid; BORDER-BOTTOM: #d6d6d6 1px solid } #content TABLE.data TR.odd { BACKGROUND-COLOR: #efefef } #content TABLE.data TH { FONT-WEIGHT: bold; FONT-SIZE: 80% } #content TABLE.data TD { FONT-SIZE: 80% } DIV.account-buttons A:link { BORDER-RIGHT: #000 0.1em solid; BORDER-TOP: #ccc 0.1em solid; = BORDER-LEFT: #ccc 0.1em solid; COLOR: #fff; BORDER-BOTTOM: #000 0.1em = solid; BACKGROUND-COLOR: #757575 } DIV.account-buttons A:visited { BORDER-RIGHT: #000 0.1em solid; BORDER-TOP: #ccc 0.1em solid; = BORDER-LEFT: #ccc 0.1em solid; COLOR: #fff; BORDER-BOTTOM: #000 0.1em = solid; BACKGROUND-COLOR: #757575 } DIV.account-buttons A:hover { BORDER-RIGHT: #000 0.1em solid; BORDER-TOP: #ccc 0.1em solid; = BORDER-LEFT: #ccc 0.1em solid; COLOR: 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PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #fff } #content H1.page-header { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; MARGIN-TOP: 0px; = PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: = 110%; BORDER-LEFT-COLOR: #dae6ff; BORDER-BOTTOM-WIDTH: 0px; = MARGIN-BOTTOM: 0px; BORDER-BOTTOM-COLOR: #dae6ff; PADDING-BOTTOM: 3px; = BORDER-TOP-COLOR: #dae6ff; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px; = BORDER-RIGHT-COLOR: #dae6ff } HR { DISPLAY: none } DIV.hr { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/line.gif) repeat-x center center; PADDING-BOTTOM: = 4px; MARGIN: 0px; PADDING-TOP: 4px } DIV.ad-top { CLEAR: both; FONT-SIZE: 80%; BACKGROUND: #fff; COLOR: #ccc; TEXT-ALIGN: = center } DIV.ad-top IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 728px! important; MARGIN: 7px 0px; WIDTH: 100%; HEIGHT: = 90px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-top EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 728px! important; MARGIN: 7px 0px; WIDTH: 100%; HEIGHT: = 90px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-center { TEXT-ALIGN: center } #content DIV.ad300x250.ad { TEXT-ALIGN: center } #content DIV.ad300x250.ad P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 70%; PADDING-BOTTOM: = 4px; MARGIN: 0px; COLOR: #999; PADDING-TOP: 0px; BACKGROUND-COLOR: = #eaeaea } #content DIV.ad300x250.ad { MARGIN: 15px 0px 0px 10px; WIDTH: 300px! important } #content DIV.ad-center DIV.ad300x250.ad { MARGIN-LEFT: auto; MARGIN-RIGHT: auto } DIV.ad-rh { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 20px 0px; PADDING-TOP: 10px; TEXT-ALIGN: center } DIV.ad-rh P { FONT-SIZE: 80%; MARGIN: 0px; COLOR: #999 } DIV.marketing.ad-rh { BORDER-RIGHT: #d3d3d3 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #d3d3d3 1px solid; PADDING-LEFT: 5px; BACKGROUND: #fdfdfd; = PADDING-BOTTOM: 5px; MARGIN: 0px 0px 20px; BORDER-LEFT: #d3d3d3 1px = solid; PADDING-TOP: 5px; BORDER-BOTTOM: #d3d3d3 1px solid; TEXT-ALIGN: = center } DIV.marketing.ad-rh H2 { FONT-SIZE: 80%; MARGIN: 0px; COLOR: #000; TEXT-ALIGN: center } * HTML DIV.marketing { BACKGROUND: #fff; MARGIN-BOTTOM: 10px } DIV.marketing.ad-rh DIV { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } DIV.marketing.ad-rh P { FONT-WEIGHT: bold; MARGIN: 0px; COLOR: #000; TEXT-ALIGN: center } * HTML DIV.marketing.ad-rh P { FONT-WEIGHT: bold; MARGIN: 0px; COLOR: #000; TEXT-ALIGN: center } DIV.marketing.ad-rh .fake-button { MARGIN-TOP: 15px; MARGIN-BOTTOM: 5px } DIV.marketing.ad-rh .fake-button A:link { BORDER-RIGHT: #000 2px solid; PADDING-RIGHT: 5px; BORDER-TOP: #c8d9db = 2px solid; PADDING-LEFT: 5px; BACKGROUND: #309; PADDING-BOTTOM: 2px; = BORDER-LEFT: #c8d9db 2px solid; COLOR: #fff; PADDING-TOP: 2px; = BORDER-BOTTOM: #000 2px solid; TEXT-DECORATION: none } DIV.marketing.ad-rh .fake-button A:visited { BORDER-RIGHT: #000 2px solid; PADDING-RIGHT: 5px; BORDER-TOP: #c8d9db = 2px solid; PADDING-LEFT: 5px; BACKGROUND: #309; PADDING-BOTTOM: 2px; = BORDER-LEFT: #c8d9db 2px solid; COLOR: #fff; PADDING-TOP: 2px; = BORDER-BOTTOM: #000 2px solid; TEXT-DECORATION: none } DIV.marketing.ad-rh P.advert { FONT-WEIGHT: normal; MARGIN-BOTTOM: 2px; COLOR: #999 } DIV.artsrc { MARGIN-BOTTOM: 10px } DIV.artsrc A { BACKGROUND-POSITION: left bottom; DISPLAY: block; BACKGROUND-REPEAT: = no-repeat } DIV.skyscraper IMG { MIN-HEIGHT: 600px; WIDTH: 100%; HEIGHT: 600px } DIV.skyscraper EMBED { MIN-HEIGHT: 600px; WIDTH: 100%; HEIGHT: 600px } DIV.skyscraper IFRAME { MIN-HEIGHT: 600px; WIDTH: 100%; HEIGHT: 600px } DIV.wide.skyscraper IMG { MAX-WIDTH: 160px } DIV.wide.skyscraper EMBED { MAX-WIDTH: 160px } DIV.wide.skyscraper IFRAME { MAX-WIDTH: 160px } * HTML DIV.skyscraper { MARGIN-LEFT: auto; OVERFLOW: hidden; MARGIN-RIGHT: auto } A.seealso { MARGIN: 0px } A.seealso:link SPAN.link { DISPLAY: block; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/008cb4/arrow.gif) no-repeat 0px 0.5em; COLOR: = #c03 } A.seealso:visited SPAN.link { DISPLAY: block; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/008cb4/arrow.gif) no-repeat 0px 0.5em; COLOR: = #c03 } A.seealso SPAN.see { FONT-WEIGHT: bold; COLOR: #c03 } A.seealso:hover SPAN.link { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; = COLOR: #c03 } #content A.backtotop:link { PADDING-RIGHT: 13px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/icons/backtotop.gif) no-repeat right center; FLOAT: = right; MARGIN: 0.5em 0px 2px 7px; TEXT-TRANSFORM: lowercase; COLOR: = #000; TEXT-DECORATION: none } #content A.backtotop:visited { PADDING-RIGHT: 13px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/icons/backtotop.gif) no-repeat right center; FLOAT: = right; MARGIN: 0.5em 0px 2px 7px; TEXT-TRANSFORM: lowercase; COLOR: = #000; TEXT-DECORATION: none } #content A.enclosed.backtotop:link { MARGIN-RIGHT: 7px } #content A.enclosed.backtotop:visited { MARGIN-RIGHT: 7px } #content A.backtotop:hover { BACKGROUND: url(/common/images/icons/backtotop_hover.gif) no-repeat = right center; COLOR: #c03 } #content A.backtotop-dark:hover { COLOR: #c03 } #content DIV.no-header { CLEAR: both; PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! = important; FLOAT: left; PADDING-BOTTOM: 2px! important; MARGIN: 0px; = WIDTH: 100%; PADDING-TOP: 0px! important; BORDER-BOTTOM: #fff 1px solid; = TEXT-ALIGN: right } #content DIV.no-header A.backtotop { DISPLAY: block; FLOAT: none } #content DIV.no-header-art { PADDING-RIGHT: 0px; MARGIN-TOP: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/dots.gif) repeat-x left bottom; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #content DIV.no-header2 { PADDING-RIGHT: 1px; MARGIN-TOP: 2em; PADDING-LEFT: 1px; BACKGROUND: = url(/common/images/dots.gif) repeat-x left top; PADDING-BOTTOM: 1px; = PADDING-TOP: 1px } #content DIV.no-header3 { PADDING-RIGHT: 1px; MARGIN-TOP: 1em; PADDING-LEFT: 1px; BACKGROUND: = url(/common/images/dots.gif) repeat-x left top; MARGIN-BOTTOM: 1em; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } #content DIV.no-header4 { PADDING-RIGHT: 0px; MARGIN-TOP: -2em; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/dots.gif) repeat-x left bottom; MARGIN-BOTTOM: 1em; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #content DIV.divider { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 5px } #footer-sponsor { TEXT-ALIGN: center } #home #content H1 { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; COLOR: #000 } #home #content H2.page { CLEAR: both; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; COLOR: = #000 } #home #content .norm { FONT-SIZE: 90% } #home #content DIV.issue H1 SPAN.description { DISPLAY: block; FONT-SIZE: 90%; COLOR: #000 } #home #content DIV.issue H1 SPAN.description SPAN.issue { FONT-WEIGHT: normal; FONT-SIZE: 90% } #home #content DIV.issue { MARGIN-BOTTOM: 1em } #home #content DIV.issue DIV.cover { FLOAT: left; WIDTH: 132px! important; MARGIN-RIGHT: 10px } #home #content DIV.issue IMG { BORDER-RIGHT: #666 1px solid; BORDER-TOP: #666 1px solid; BORDER-LEFT: = #666 1px solid; WIDTH: 130px! important; BORDER-BOTTOM: #666 1px solid } #home #content DIV.issue A.about-the-cover:link { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat left center; MARGIN: 4px = 0px 9px } #home #content DIV.issue A.about-the-cover:visited { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat left center; MARGIN: 4px = 0px 9px } #home #content DIV.issue A.about-the-cover:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat left center } #home #content .cover .impact-factor { DISPLAY: block; FONT-SIZE: 70% } #home #content .cover .impact-factor SPAN { FONT-WEIGHT: bold } #home #content DIV.issue DIV.issue-links { MARGIN-LEFT: 162px } #home #content DIV.issue UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; 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10px; FONT-SIZE: 90%; BACKGROUND: = url(/common/images/icons/309/arrow_light.gif) no-repeat 0px 0.5em; = MARGIN: 0px } * HTML #home #content DIV.issue-links UL.issue-links LI A:link { BACKGROUND: url(/common/images/icons/309/arrow_light.gif) no-repeat 0px = 0.8em } * HTML #home #content DIV.issue-links UL.issue-links LI A:visited { BACKGROUND: url(/common/images/icons/309/arrow_light.gif) no-repeat 0px = 0.8em } #home #content .container { FLOAT: left } #home #content .featurebox { MARGIN: 10px 0px 20px } #home #content .featurebox .padder { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } #home #content .featurebox .padder .heading { MARGIN-TOP: -5px } #home #content .colour.featurebox { BACKGROUND-COLOR: #f3f7fb } #home #content DIV.left { FLOAT: left; WIDTH: 48% } #home #content DIV.right { FLOAT: right; WIDTH: 48% } #home #content .featurebox H3 { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-SIZE: 80%; BACKGROUND: = #309; PADDING-BOTTOM: 3px; MARGIN: 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#fff; PADDING-TOP: 1px; = BORDER-BOTTOM: #555 1px solid; TEXT-ALIGN: center; TEXT-DECORATION: none } #home #content DIV.cover A.subscribe:hover { BACKGROUND-COLOR: #c03 } * HTML #home #content A.register { BACKGROUND: url(/common/images/icons/fff/envelope.gif) no-repeat 0px = 0.5em } #home #content A.register { DISPLAY: block; PADDING-LEFT: 20px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/icons/fff/envelope.gif) no-repeat 0px 0.3em } * HTML #home #content A.recommend { BACKGROUND: url(/common/images/icons/fff/tick.gif) no-repeat 0px 0px } #home #content A.recommend { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 20px; FONT-SIZE: 80%; = BACKGROUND: url(/common/images/icons/fff/tick.gif) no-repeat 0px 0.2em; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } #home #content DIV.callpapers { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: 20px = 0px 10px; BORDER-LEFT: #e7e7e7 1px solid; PADDING-TOP: 5px; = BORDER-BOTTOM: #e7e7e7 1px solid; BACKGROUND-COLOR: #f3f7fb; = TEXT-DECORATION: none } #home #content DIV.callpapers H2 { FONT-SIZE: 90%; MARGIN: 0px } #home #content DIV.callpapers P { FONT-SIZE: 80%; MARGIN: 0px } #home #content .pl-list { BORDER-RIGHT: #dae6ff 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: = #dae6ff 1px solid; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #dae6ff 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: = #dae6ff 1px solid } #home #content .pl-list .atl { FONT-WEIGHT: normal; FONT-SIZE: 90%; MARGIN: 0px } #home #content .pl-list UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 10px 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #home #content .pl-list LI { MARGIN: 15px 0px } #home #content .pl-list P { FONT-SIZE: 90%; MARGIN: 0px } #about-cover #content H2 { FONT-SIZE: 90%; MARGIN: 1em 0px } #about-cover #content DIV.coverimage { PADDING-RIGHT: 10px; MARGIN-TOP: 1em; PADDING-LEFT: 10px; = PADDING-BOTTOM: 0px; PADDING-TOP: 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