From: Subject: Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation -- Mayr et al. 315 (5818): 1576 -- Science Date: Thu, 8 May 2008 14:27:27 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0232_01C8B117.A3CBB660" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_0232_01C8B117.A3CBB660 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencemag.org/cgi/content/abstract/315/5818/1576 Disrupting the Pairing Between let-7 and Hmga2 = Enhances Oncogenic Transformation -- Mayr et al. 315 (5818): 1576 -- = Science
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Originally published in = Science Express=20 on 22 February 2007
Science 16 March = 2007:
Vol. 315.=20 no. 5818, pp. 1576 - 1579
DOI: = 10.1126/science.1137999
Prev | Tab= le=20 of Contents | Next=20

Reports

Disrupting the Pairing Between let-7 and Hmga2 = Enhances=20 Oncogenic Transformation

Christine=20 Mayr,1 Michael T. = Hemann,2=20 David P. Bartel1*

MicroRNAs (miRNAs) are 3D~=2022-nucleotide RNAs=20 that can pair to sites within messenger RNAs to specify = posttranscriptional repression of these messages. = Aberrant=20 miRNA expression can contribute to tumorigenesis, but = which of=20 the many miRNA-target relationships are relevant to = this=20 process has been unclear. Here, we report that = chromosomal=20 translocations previously associated with human tumors = disrupt=20 repression of High Mobility Group A2 (Hmga2) = by=20 let-7 miRNA. This disrupted repression promotes=20 anchorage-independent growth, a characteristic of = oncogenic=20 transformation. Thus, losing miRNA-directed repression = of an=20 oncogene provides a mechanism for tumorigenesis, and = disrupting=20 a single miRNA-target interaction can produce an = observable=20 phenotype in mammalian cells.

1 Howard Hughes Medical Institute = and=20 Department of Biology, Massachusetts Institute of Technology, and=20 Whitehead Institute for Biomedical Research, 9 Cambridge Center,=20 Cambridge, MA 02142, USA.
2 Center for Cancer = Research,=20 Massachusetts Institute of Technology, Cambridge, MA 02139, USA. =

* To whom correspondence should be addressed. = E-mail: dbartel{at}wi.mit.edu

Read = the=20 Full Text

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FONT-WEIGHT: bold } .Links { =09 } .LinkNext { PADDING-RIGHT: 10px; BACKGROUND: url(/icons/icon.arrow.53859F.lg.r.gif) = no-repeat 100% 3px } .LinkPrev { PADDING-LEFT: 10px; BACKGROUND: url(/icons/icon.arrow.53859F.lg.l.gif) = no-repeat 0px 3px } DIV.LinkBack A { PADDING-LEFT: 10px; FONT-WEIGHT: bold; BACKGROUND: = url(/icons/icon.arrow.53859F.lg.l.gif) no-repeat 0px 2px; = TEXT-DECORATION: none } DIV.LinkTop { MARGIN-TOP: 10px; FONT-SIZE: 70%; MARGIN-RIGHT: 1em; TEXT-ALIGN: right } .LinkHelp { =09 } .Invisible { DISPLAY: none } .Separator { MARGIN: 10px 0px; TEXT-ALIGN: center } .Exception { =09 } .Left { FLOAT: left; MARGIN: 0px 10px 10px 0px } .Right { FLOAT: right; MARGIN: 0px 0px 10px 10px } P.ImageAndCaption { FONT-SIZE: 65%! important } P.ImageAndCaption IMG { DISPLAY: block; MARGIN-BOTTOM: 4px } .FeatureLeft { FLOAT: left; MARGIN: 10px } .FeatureLeft IMG { BORDER-RIGHT: #333 1px solid; BORDER-TOP: #333 1px solid; BORDER-LEFT: = #333 1px solid; BORDER-BOTTOM: #333 1px solid } .FeatureLeft P.credit { MARGIN-TOP: 0px! important; FONT-SIZE: 85%! important } .FeatureLeft P.caption { FONT-SIZE: 90%! important } .FeatureRight { FLOAT: right; MARGIN: 10px } .FeatureRight IMG { BORDER-RIGHT: #333 1px solid; BORDER-TOP: #333 1px solid; BORDER-LEFT: = #333 1px solid; BORDER-BOTTOM: #333 1px solid } .FeatureRight P.credit { MARGIN-TOP: 0px! important; FONT-SIZE: 85%! important } .FeatureRight P.caption { FONT-SIZE: 90%! important } #MainColumn .ReadFullText A { PADDING-LEFT: 20px; FONT-WEIGHT: 700; FONT-SIZE: 110%; BACKGROUND: = url(/icons/readfulltext.gif) no-repeat 2px 0px } #MainColumn .EdPromo { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 5px; BACKGROUND: #ffffdd; MARGIN-BOTTOM: 15px; = PADDING-BOTTOM: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: #ccc 1px solid; = WIDTH: 175px; MARGIN-RIGHT: 5px; PADDING-TOP: 5px; BORDER-BOTTOM: #ccc = 1px solid } #MainColumn .EdPromo H3 { COLOR: #666 } #MainColumn .EdPromo P { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px } #MainColumn .EdPromo IMG { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BORDER-LEFT: = #ccc 1px solid; BORDER-BOTTOM: #ccc 1px solid } .RelatedMaterial { =09 } .Even { =09 } .Odd { =09 } TABLE.DataTable TR.Even TD { =09 } TABLE.DataTable TR.Even TH { =09 } TABLE.DataTable TR.Odd TD { BACKGROUND: #ebeff2 } TABLE.DataTable TR.Odd TH { BACKGROUND: #ebeff2 } #MainColumn SPAN.Highlight { FONT-WEIGHT: bold; COLOR: #cc3333 } #MainColumn .drop { PADDING-RIGHT: 3px; DISPLAY: block; FONT-WEIGHT: 700; FONT-SIZE: 200%; = FLOAT: left } .ErrorMsg { BORDER-RIGHT: #c33 1px solid; PADDING-RIGHT: 8px; BORDER-TOP: #c33 1px = solid; PADDING-LEFT: 8px; BACKGROUND: #fff; PADDING-BOTTOM: 8px; MARGIN: = 0.5em 0px; BORDER-LEFT: #c33 1px solid; PADDING-TOP: 8px; BORDER-BOTTOM: = #c33 1px solid } .ErrorMsg P { MARGIN: 0px; COLOR: #c33 } .DEBUG { BACKGROUND: #fcc } .NavGroup { MARGIN-BOTTOM: 16px } .NavGroup H3 { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; FONT-SIZE: 75%; BACKGROUND: = #51829a; PADDING-BOTTOM: 2px; COLOR: #fff; PADDING-TOP: 2px } .NavGroup H3 SPAN { BORDER-RIGHT: #8aaaba 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #8aaaba 1px solid; DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: = 2px; BORDER-LEFT: #8aaaba 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: = #8aaaba 1px solid } .NavGroup H3 SPAN SPAN { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = DISPLAY: inline; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; BORDER-LEFT: = medium none; PADDING-TOP: 0px; BORDER-BOTTOM: medium none } .NavGroup .LinkList { BACKGROUND: #fff } .NavGroup .LinkList LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 75%; PADDING-BOTTOM: = 0px; MARGIN: 0px; COLOR: #333; PADDING-TOP: 0px; BORDER-BOTTOM: #c6d7df = 1px solid } .NavGroup .LinkList LI A { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 12px; BACKGROUND: = url(/icons/icon.arrow.53859F.sm.gif) no-repeat 3px 0.4em; = PADDING-BOTTOM: 4px; COLOR: #2e6d8f; PADDING-TOP: 2px } .NavGroup .LinkList LI.Active { COLOR: #333 } .NavGroup .LinkList LI.Active A { =09 } .NavGroup .LinkList LI.Active A { BACKGROUND-IMAGE: url(/icons/icon.arrow.333333.sm.gif); COLOR: #333 } .NavGroup .LinkList LI.Active SPAN { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 12px; BACKGROUND: = url(/icons/icon.arrow.666666.sm.gif) #f0f0f0 no-repeat 3px 0.4em; = PADDING-BOTTOM: 4px; PADDING-TOP: 2px } .NavGroup .LinkList LI.Active SPAN SPAN { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; PADDING-TOP: = 0px } .NavGroup .LinkList LI.Expanded { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND-IMAGE: none; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .NavGroup .LinkList LI.Expanded A { COLOR: #2e6d8f } .NavGroup .LinkList LI.Expanded A { =09 } .NavGroup .LinkList LI.Expanded A { BACKGROUND-IMAGE: url(/icons/icon.arrow.333333.sm.dn.gif) } .NavGroup .LinkList LI.Expanded SPAN { BACKGROUND-POSITION: 3px 0.5em; BACKGROUND-IMAGE: = url(/icons/icon.arrow.666666.sm.dn.gif) } .NavGroup .LinkList LI.Expanded UL { BORDER-TOP: #c6d7df 1px solid } .NavGroup .LinkList LI.Expanded LI A { BACKGROUND-IMAGE: url(/icons/icon.arrow.53859F.sm.gif); COLOR: #2e6d8f } .NavGroup .Item .LinkList LI.Active { FONT-WEIGHT: bold; BACKGROUND-COLOR: #fff } .NavGroup .Item .LinkList LI.Active SPAN { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 12px; BACKGROUND: = url(/icons/icon.arrow.333333.sm.gif) #fff no-repeat 3px 0.36em; = PADDING-BOTTOM: 4px; PADDING-TOP: 2px } .NavGroup .Item .LinkList LI.Active SPAN SPAN { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; PADDING-TOP: = 0px } * HTML .NavGroup .LinkList LI.Active { BACKGROUND-POSITION: 3px 0.6em } * HTML .NavGroup .LinkList LI A { BACKGROUND-POSITION: 5px 0.6em; MARGIN-TOP: 0px; PADDING-BOTTOM: 0.3em; = PADDING-TOP: 0px } * HTML .NavGroup .LinkList LI.Active SPAN { PADDING-RIGHT: 0px; BACKGROUND-POSITION: 5px 0.5em; PADDING-LEFT: 12px; = PADDING-BOTTOM: 4px; PADDING-TOP: 0px } * HTML .NavGroup .LinkList LI.Active SPAN SPAN { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } * HTML .NavGroup .LinkList LI .Icon { MARGIN-TOP: 2px; VERTICAL-ALIGN: baseline } * HTML .NavGroup .LinkList LI.Expanded A { BACKGROUND-POSITION: 4px 0.5em } * HTML .NavGroup .LinkList LI.Expanded UL { BORDER-TOP: medium none } *:first-child + HTML .NavGroup .LinkList LI.Active { BACKGROUND-POSITION: 3px 0.7em } *:first-child + HTML .NavGroup .LinkList LI.Expanded A { BACKGROUND-POSITION: 4px 0.7em } *:first-child + HTML .NavGroup .LinkList LI.Active SPAN { BACKGROUND-POSITION: 5px 0.7em } *:first-child + HTML .NavGroup .LinkList LI A { BACKGROUND-POSITION: 5px 0.7em } .NavGroup .LinkList .LinkList { PADDING-RIGHT: 0px; PADDING-LEFT: 12px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .NavGroup .LinkList .LinkList LI { BORDER-TOP: #53829c 1px dotted; FONT-SIZE: 100%; BORDER-BOTTOM: medium = none; BACKGROUND-COLOR: #fff } .NavGroup .LinkList .LinkList LI.Active { BACKGROUND-COLOR: #f0f0f0 } .NavGroup .LinkList .LinkList LI A { BACKGROUND-IMAGE: url(/icons/icon.arrow.53859F.sm.gif) } .NavGroup .LinkList .LinkList LI.Active A { COLOR: #333 } .NavGroup .LinkList .LinkList LI SPAN { BACKGROUND-IMAGE: url(/icons/icon.arrow.333333.sm.gif) } .NavGroup .LinkList .LinkList LI:first-child { BORDER-TOP: 0px } * HTML .NavGroup .LinkList .LinkList { MARGIN: 0px } * HTML .NavGroup .LinkList .LinkList LI { FONT-SIZE: 100%; HEIGHT: 16px } * HTML .NavGroup .LinkList .LinkList LI.Active { =09 } * HTML .NavGroup .LinkList .LinkList LI.Active SPAN { PADDING-TOP: 3px } * HTML .NavGroup .LinkList .LinkList LI.Active SPAN SPAN { PADDING-TOP: 0px } * HTML .NavGroup .LinkList .LinkList LI A { PADDING-TOP: 3px } #navgroup_my-science UL.LinkList { MARGIN-BOTTOM: 0.4em } #navgroup_my-science P { PADDING-LEFT: 0.5em; FONT-SIZE: 70% } #navgroup_about-search P { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-SIZE: 70%; PADDING-BOTTOM: = 0px; COLOR: #666; PADDING-TOP: 5px } #navgroup_about-search P A { TEXT-DECORATION: underline } #navgroup_related-information LI { BORDER-BOTTOM: medium none } .NavGroup#navgroup_article-views .Exception { PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .NavGroup#navgroup_related-content .Exception LI A { BACKGROUND-IMAGE: url(/icons/icon.arrow.797979.sm.dn.gif) } .Promo { MARGIN-BOTTOM: 12px } .Promo H5 { FONT-WEIGHT: normal; FONT-SIZE: 80%; MARGIN-BOTTOM: 0.5em; COLOR: #666 } .Promo .Item { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: medium = none; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; BORDER-LEFT: #ccc 1px = solid; PADDING-TOP: 3px; BORDER-BOTTOM: #ccc 1px solid } .Promo .LinkList { MARGIN-BOTTOM: 0px } .Promo .LinkList LI { FONT-SIZE: 70%; BACKGROUND: url(/icons/icon.arrow.53859F.sm.gif) = no-repeat 2px 0.2em } * HTML .Promo .LinkList LI { BACKGROUND-POSITION: 2px 0.6em; MARGIN-TOP: 0px; PADDING-BOTTOM: 0.3em; = PADDING-TOP: 0px } *:first-child + HTML .Promo .LinkList LI { BACKGROUND-POSITION: 2px 0.6em } #journal_search #keyword { WIDTH: 127px } #journal_search #search_type { WIDTH: 132px } #journal_search .LinkList { =09 } * HTML #journal_search .LinkList LI { MARGIN-BOTTOM: 0px; MARGIN-RIGHT: 2em } #select_article { MARGIN: 2px 0px } #search_type { MARGIN: 2px 0px } #keyword { MARGIN: 2px 0px } #select_issue { WIDTH: 150px } #MainColumn #page-nav { FONT-WEIGHT: bold; FONT-SIZE: 70%; COLOR: #999; MARGIN-RIGHT: 4px } #MainColumn #page-nav A { TEXT-DECORATION: none } #MainColumn #page-nav A:hover { TEXT-DECORATION: underline } #MainColumn .page-nav_next { PADDING-RIGHT: 10px; BACKGROUND: url(/icons/icon.arrow.999999.lg.r.gif) = no-repeat 100% 3px } #MainColumn .page-nav_prev { PADDING-LEFT: 10px; BACKGROUND: url(/icons/icon.arrow.999999.lg.l.gif) = no-repeat 0px 3px } #MainColumn A.page-nav_next { BACKGROUND-IMAGE: url(/icons/icon.arrow.53859F.lg.r.gif) } #MainColumn A.page-nav_prev { BACKGROUND-IMAGE: url(/icons/icon.arrow.53859F.lg.l.gif) } #MainColumn #article-info { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px } #MainColumn .article-tools { FONT-WEIGHT: bold; FONT-SIZE: 75%; MARGIN: 4px 0px; COLOR: #666; = TEXT-ALIGN: right } #MainColumn .article-tools .Button { MARGIN-LEFT: 4px } #MainColumn DL.LinkList { CLEAR: left; MARGIN-TOP: 12px } #MainColumn DL.LinkList DT { CLEAR: both; FONT-SIZE: 75%; MARGIN: 0px } #MainColumn DL.LinkList DT A { FONT-WEIGHT: bold; TEXT-DECORATION: none } #MainColumn DL.LinkList DT A .Photo { BORDER-RIGHT: #666 1px solid; BORDER-TOP: #666 1px solid; FLOAT: left; = MARGIN: 0px 1em 1em 0px; BORDER-LEFT: #666 1px solid; WIDTH: 70px; = BORDER-BOTTOM: #666 1px solid; HEIGHT: 50px } #MainColumn DL.LinkList DD { FONT-SIZE: 70%; MARGIN: 0px 0px 1em } #MainColumn DL.ArticleList { CLEAR: left; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 1.5em; PADDING-TOP: 0px } #MainColumn DL.ArticleList DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 75%; PADDING-BOTTOM: 0px; MARGIN: 1em 0px 0px; COLOR: #333; PADDING-TOP: = 0px } #MainColumn DL.ArticleList DT INPUT { MARGIN-RIGHT: 6px } #MainColumn DL.Exception DT { COLOR: #666; TEXT-INDENT: 0px } #MainColumn DL.ArticleList DT STRONG { FONT-WEIGHT: normal; FONT-SIZE: 90%; MARGIN-BOTTOM: 0.3em; = TEXT-TRANSFORM: uppercase; COLOR: #666; LETTER-SPACING: 0.07em } #MainColumn DL.ArticleList DD { FONT-SIZE: 75%; MARGIN: 0px 0px 1em } #MainColumn DL.ArticleList DD A { FONT-WEIGHT: bold; WHITE-SPACE: nowrap; TEXT-DECORATION: none } #MainColumn DL.ArticleList DT A:hover { TEXT-DECORATION: underline } #MainColumn DL.ArticleList DD .RelatedMaterial { FONT-SIZE: 90% } #MainColumn DL.ArticleList DD .RelatedMaterial { COLOR: #c33! important } #MainColumn DL.ArticleList DD .RelatedMaterial A { COLOR: #c33! important } #MainColumn DL.ArticleList DD .RelatedMaterial A { FONT-WEIGHT: normal; TEXT-DECORATION: underline } #MainColumn #RelatedLinks { BORDER-TOP: #ccc 1px solid; PADDING-TOP: 15px } #MainColumn #RelatedLinks .LinkList { MARGIN-TOP: 10px } #MainColumn #CitingArticles { BORDER-TOP: #ccc 1px solid; PADDING-TOP: 15px } #SearchBox { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; BACKGROUND: #eee; MARGIN-BOTTOM: = 10px; PADDING-BOTTOM: 2px; PADDING-TOP: 2px } #journal_search { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; BACKGROUND: #eee; MARGIN-BOTTOM: = 10px; PADDING-BOTTOM: 2px; PADDING-TOP: 2px } #SearchBox .BorderFix { BORDER-RIGHT: #c3c3c3 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: = #c3c3c3 1px solid; PADDING-LEFT: 4px; PADDING-BOTTOM: 4px; BORDER-LEFT: = #c3c3c3 1px solid; PADDING-TOP: 4px; BORDER-BOTTOM: #c3c3c3 1px solid } #journal_search .BorderFix { BORDER-RIGHT: #c3c3c3 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: = #c3c3c3 1px solid; PADDING-LEFT: 4px; PADDING-BOTTOM: 4px; BORDER-LEFT: = #c3c3c3 1px solid; PADDING-TOP: 4px; BORDER-BOTTOM: #c3c3c3 1px solid } #SearchBox H3 { FONT-SIZE: 75%; MARGIN-BOTTOM: 0.5em; COLOR: #747474 } #journal_search H3 { FONT-SIZE: 75%; MARGIN-BOTTOM: 0.5em; COLOR: #747474 } #SearchBox .LinkList { MARGIN: 0px } #journal_search .LinkList { MARGIN: 0px } #SearchBox .LinkList LI { MARGIN-TOP: 0.5em; PADDING-LEFT: 0px; FONT-SIZE: 70% } #journal_search .LinkList LI { MARGIN-TOP: 0.5em; PADDING-LEFT: 0px; FONT-SIZE: 70% } #SearchBox .Inputs LI { FONT-SIZE: 90%! important; MARGIN-BOTTOM: 0px! important } #journal_search .Inputs LI { FONT-SIZE: 90%! important; MARGIN-BOTTOM: 0px! important } #SearchBox LABEL { FONT-SIZE: 70% } #journal_search LABEL { FONT-SIZE: 70% } #journal_search_volume_form { MARGIN-BOTTOM: 10px } #journal_search_volume_form .FormTable TH { PADDING-LEFT: 0.5em } #journal_search_volume_go { MARGIN-LEFT: 8px } #SearchBox .TextInput { WIDTH: 125px } #GlobalLoginBlock { COLOR: #333; FONT-FAMILY: 'Lucida Grande', arial, helvetica, sans-serif } #GlobalLoginBlock A { COLOR: #53859f } #GlobalLoginBlock { FONT-SIZE: 16px } #GlobalLoginBlock TD { FONT-SIZE: 16px } #GlobalLoginBlock H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #GlobalLoginBlock H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #GlobalLoginBlock H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #GlobalLoginBlock H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #GlobalLoginBlock H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #GlobalLoginBlock H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #GlobalLoginBlock H1 { FONT-SIZE: 120% } #GlobalLoginBlock H2 { FONT-SIZE: 110% } #GlobalLoginBlock H3 { FONT-SIZE: 100% } #GlobalLoginBlock H4 { FONT-SIZE: 90% } #GlobalLoginBlock H5 { FONT-SIZE: 80% } #GlobalLoginBlock H6 { FONT-SIZE: 75% } #GlobalLoginBlock P { MARGIN-TOP: 0px; FONT-SIZE: 75% } #GlobalLoginBlock FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #GlobalLoginBlock .NoBullet { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 1em; PADDING-TOP: 0px } #GlobalLoginBlock .NoBullet LI { PADDING-LEFT: 0px; BACKGROUND-IMAGE: none! important; LIST-STYLE-TYPE: = none } #GlobalLoginBlock H2 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 110%; MARGIN-BOTTOM: 0.5em; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: none; BORDER-LEFT: medium none; = COLOR: #333; PADDING-TOP: 0px; BORDER-BOTTOM: medium none } #GlobalLoginBlock #access-denied { MARGIN-BOTTOM: 25px } #GlobalLoginBlock #access-denied H4 { FONT-SIZE: 75%; COLOR: #666 } #GlobalLoginBlock #access-denied P.Link { MARGIN-BOTTOM: 0px } #GlobalLoginBlock #access-denied .LayoutTable { BORDER-TOP: #d9e4e9 1px solid } #GlobalLoginBlock #access-denied .LayoutTable TD.LeftCell { BORDER-RIGHT: #d9e4e9 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: = 20px; PADDING-BOTTOM: 0px; PADDING-TOP: 20px } #GlobalLoginBlock #access-denied .LayoutTable TD.RightCell { PADDING-RIGHT: 0px; PADDING-LEFT: 20px; BACKGROUND: = url(/icons/bg.barrier.question.gif) no-repeat 100% 6px; PADDING-BOTTOM: = 0px; PADDING-TOP: 20px } #GlobalLoginBlock #access-denied .LayoutTable TD.RightCell H4 { MARGIN-BOTTOM: 10px; TEXT-TRANSFORM: uppercase } #GlobalLoginBlock #access-denied .LayoutTable TD.RightCell .LinkList { MARGIN: 0px } #GlobalLoginBlock #access-denied .LayoutTable TD.RightCell .LinkList LI = { PADDING-LEFT: 0px; FONT-SIZE: 75%; MARGIN-LEFT: 15px; LIST-STYLE-TYPE: = circle } #GlobalLoginBlock #access-denied .LayoutTable TD.RightCell .LinkList LI = A { TEXT-DECORATION: underline } #GlobalLoginBlock #access-denied H2 SPAN.Message { MARGIN-TOP: 5px; DISPLAY: block; FONT-WEIGHT: 400; FONT-SIZE: 75%; = FLOAT: 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important; PADDING-BOTTOM: 0px; = MARGIN: 1.5em 0px 1.4em; TEXT-TRANSFORM: uppercase! important; = BORDER-LEFT: medium none; COLOR: #666! important; PADDING-TOP: 0px; = BORDER-BOTTOM: medium none } #MainColumn .AuthorSummary H2#ArticleTitle .SumHead { FONT-SIZE: 90%; FONT-STYLE: italic } #MainColumn .AuthorSummary .Left { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; BORDER-LEFT: #ccc 1px = solid; PADDING-TOP: 10px; BORDER-BOTTOM: #ccc 1px solid } .AuthorSummary .Left #SumFig { WIDTH: 300px } #MainColumn .AuthorSummary .Left P#ResizeImage { PADDING-RIGHT: 0px; MARGIN-TOP: 0px! important; PADDING-LEFT: 10px; = FONT-SIZE: 85%! important; BACKGROUND: url(/icons/blueplus.gif) = no-repeat 0px 0.4em; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #MainColumn .AuthorSummary .Left P.caption { FONT-WEIGHT: 700; FONT-SIZE: 85%! important; WIDTH: 300px } #MainColumn .AuthorSummary .Left P.credit { FONT-SIZE: 70%! important; TEXT-TRANSFORM: uppercase; WIDTH: 300px } #MainColumn .AuthorSummary P.SumRefHead { FONT-WEIGHT: 700 } #MainColumn .AuthorSummary P.ReadFullText { FONT-SIZE: 90%! important } #MainColumn .AuthorSummary .EdPromo H3 { FONT-SIZE: 85%! important } #MainColumn .AuthorSummary .EdPromo P { FONT-SIZE: 85%! important } #MainColumn .AuthorSummary .SurvLinkBox { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; BORDER-LEFT: #ccc 1px = solid; WIDTH: auto; PADDING-TOP: 5px; BORDER-BOTTOM: #ccc 1px solid } #MainColumn #EPAnnouncement { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 5px; FONT-SIZE: 85%! important; PADDING-BOTTOM: = 5px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 5px; BORDER-BOTTOM: #ccc = 1px solid } #MainColumn #EPHypernotes { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 10px; PADDING-TOP: 10px } #MainColumn #EPHypernotes H4.subhead { FONT-WEIGHT: 700; FONT-SIZE: 100%! important; COLOR: #a70716; = PADDING-TOP: 20px; FONT-STYLE: italic } #MainColumn #EPHypernotes H3 { TEXT-TRANSFORM: none! important } .MagazineSubjectIndex { =09 } #PageWrapper .MagazineSubjectIndex #MainColumn { PADDING-LEFT: 17px } .MagazineSubjectIndex #MainColumn H2 { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; FONT-SIZE: 75%; BACKGROUND: = #53829c; PADDING-BOTTOM: 2px; MARGIN: 5px 0px; COLOR: #fff; PADDING-TOP: = 2px } .MagazineSubjectIndex #MainColumn H2 SPAN { BORDER-RIGHT: #bbbbbb 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #bbbbbb 1px solid; DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: = 2px; BORDER-LEFT: #bbbbbb 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: = #bbbbbb 1px solid } .MagazineSubjectIndex #MainColumn H2 SPAN SPAN { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = DISPLAY: inline; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; BORDER-LEFT: = medium none; PADDING-TOP: 0px; BORDER-BOTTOM: medium none } .MagazineSubjectIndex #MainColumn H3 { FONT-SIZE: 95% } .MagazineSubjectIndex #MainColumn H4 { FONT-SIZE: 75%; MARGIN-BOTTOM: 0.5em; COLOR: #666 } .MagazineSubjectIndex #MainColumn DL.ArticleList DT { PADDING-RIGHT: 0px; PADDING-LEFT: 26px; PADDING-BOTTOM: 0px; = TEXT-INDENT: -26px; PADDING-TOP: 0px } .MagazineSubjectIndex #MainColumn DL.Exception DT { COLOR: #666; TEXT-INDENT: 0px } .MagazineSubjectIndex #MainColumn DL.ArticleList DD { MARGIN: 0px 0px 1em 26px; COLOR: #666 } .MagazineSubjectIndex #journal_search_keyword_form { MARGIN-LEFT: 10px; WIDTH: 150px } .MagazineSubjectIndex #journal_search_keyword_form #keyword { WIDTH: 144px } .MagazineSubjectIndex #journal_search_keyword_form #search_type { WIDTH: 150px } .MagazineSubjectIndex #page-nav { RIGHT: 0px; POSITION: absolute; TOP: 3px } .MagazineSubjectIndex #MainColumn #table-of-contents .HorizList LI { WIDTH: 110px; MARGIN-RIGHT: 10px } .MagazineSubjectIndex #MainColumn #table-of-contents .HorizList LI { WIDTH: auto } .MagazineSubjectIndex .LinkTop { MARGIN-BOTTOM: 1em } .MagazineSubjectIndex #issue_contents_wrapper { PADDING-LEFT: 12px; BORDER-BOTTOM: #e8e8e8 5px solid } .MagazineSubjectIndex #issue_contents_wrapper H4 { COLOR: #c00 } .MagazineAuthorIndex { =09 } #PageWrapper .MagazineAuthorIndex #MainColumn { PADDING-LEFT: 17px } .MagazineAuthorIndex #MainColumn H2 { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; FONT-SIZE: 75%; BACKGROUND: = #53829c; PADDING-BOTTOM: 2px; MARGIN: 5px 0px; COLOR: #fff; PADDING-TOP: = 2px } .MagazineAuthorIndex #MainColumn H2 SPAN { BORDER-RIGHT: #bbbbbb 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #bbbbbb 1px solid; DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: = 2px; BORDER-LEFT: #bbbbbb 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: = #bbbbbb 1px solid } .MagazineAuthorIndex #MainColumn H2 SPAN SPAN { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = DISPLAY: inline; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; BORDER-LEFT: = medium none; PADDING-TOP: 0px; BORDER-BOTTOM: medium none } .MagazineAuthorIndex #MainColumn H3 { FONT-SIZE: 95% } .MagazineAuthorIndex #MainColumn H4 { FONT-SIZE: 75%; MARGIN-BOTTOM: 0.5em; COLOR: #666 } .MagazineAuthorIndex #MainColumn #journal_search_keyword_form { =09 } .MagazineAuthorIndex #MainColumn #journal_search_keyword_form #keyword { WIDTH: 144px } .MagazineAuthorIndex #MainColumn #journal_search_keyword_form = #search_type { WIDTH: 150px } .MagazineAuthorIndex #page-nav { RIGHT: 0px; POSITION: absolute; TOP: 3px } .MagazineAuthorIndex #MainColumn #table-of-contents .Item .HorizList { BORDER-TOP: medium none; MARGIN: 10px 0px 0px; HEIGHT: 1.5em } .MagazineAuthorIndex #MainColumn #table-of-contents .Item .HorizList LI = { FONT-SIZE: 75%; BACKGROUND: none transparent scroll repeat 0% 0%; = MARGIN-LEFT: 0px; COLOR: #999; MARGIN-RIGHT: 0.4em } .MagazineAuthorIndex #MainColumn #table-of-contents .HorizList { CLEAR: left } .MagazineAuthorIndex #MainColumn #table-of-contents .HorizList LI { FONT-WEIGHT: bold; FONT-SIZE: 70%; MARGIN: 0.2em 8px 0.2em 0.4em; = WIDTH: 140px } .MagazineAuthorIndex #MainColumn #table-of-contents .HorizList LI { WIDTH: auto } .MagazineAuthorIndex #MainColumn #table-of-contents FORM { MARGIN-TOP: 8px } .MagazineAuthorIndex #MainColumn #table-of-contents FORM H4 { FONT-WEIGHT: normal; FONT-SIZE: 70%; TEXT-TRANSFORM: uppercase; = LETTER-SPACING: 0.07em } .MagazineAuthorIndex #MainColumn .DataTable { MARGIN: 10px 0px 0px 20px; WIDTH: 560px } .MagazineAuthorIndex #MainColumn .LinkTop { MARGIN-TOP: 3px; MARGIN-BOTTOM: 10px } * HTML .MagazineAuthorIndex #MainColumn .DataTable { MARGIN-LEFT: 0px } .MagazinePreviousIssues { =09 } .MagazinePreviousIssues #MainColumn { PADDING-LEFT: 10px; COLOR: #333 } .MagazinePreviousIssues #MainColumn A { TEXT-DECORATION: underline } .MagazinePreviousIssues #MainColumn H2 { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 95%; MARGIN-BOTTOM: 0.8em; PADDING-BOTTOM: 0px; = TEXT-TRANSFORM: none; BORDER-LEFT: 0px; COLOR: #666; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px } .MagazinePreviousIssues #MainColumn H3 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 80%; MARGIN-BOTTOM: 1em; PADDING-BOTTOM: = 0px; TEXT-TRANSFORM: uppercase; BORDER-LEFT: medium none; COLOR: #666; = PADDING-TOP: 0px; BORDER-BOTTOM: medium none } .MagazinePreviousIssues #MainColumn H4 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 75%; MARGIN-BOTTOM: 1em; PADDING-BOTTOM: = 0px; TEXT-TRANSFORM: none; BORDER-LEFT: medium none; COLOR: #666; = PADDING-TOP: 0px; BORDER-BOTTOM: medium none } .MagazinePreviousIssues #MainColumn .Item { PADDING-RIGHT: 0px; BORDER-TOP: #e6e6e6 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 16px; PADDING-TOP: 16px } .MagazinePreviousIssues #MainColumn .Item .LayoutTable { CLEAR: both } .MagazinePreviousIssues #MainColumn .Item TD { PADDING-BOTTOM: 16px } .MagazinePreviousIssues #MainColumn .Item TD DIV A { =09 } .MagazinePreviousIssues #MainColumn .Item TD DIV IMG { BORDER-RIGHT: #333 1px solid; BORDER-TOP: #333 1px solid; BORDER-LEFT: = #333 1px solid; BORDER-BOTTOM: #333 1px solid } .MagazinePreviousIssues #MainColumn .Item TD P { PADDING-RIGHT: 8px; FONT-SIZE: 70%; MARGIN: 5px 0px 0.5em; WIDTH: 100px } .MagazinePreviousIssues #MainColumn .Item TD P SPAN { FONT-WEIGHT: bold } .MagazinePreviousIssues #MainColumn .Item TD P STRONG { FONT-WEIGHT: normal; COLOR: #c33 } .MagazinePreviousIssues #MainColumn .Item TD .LinkList { MARGIN: 0px } .MagazinePreviousIssues #MainColumn .Item TD .LinkList LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 70%; BACKGROUND: none = transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px 0px = 0.2em; PADDING-TOP: 0px } .MagazinePreviousIssues #MainColumn .LinkList LI { BACKGROUND: url(/icons/icon.dot.53859F.gif) no-repeat 0px 2px } .MagazinePreviousIssues #MainColumn .Exception { BORDER-TOP: #e0e0e0 1px solid; MARGIN-TOP: 16px; PADDING-TOP: 10px } .MagazinePreviousIssues #MainColumn .Exception LI { FONT-WEIGHT: bold } .MagazinePreviousIssues #MainColumn .Item DT { CLEAR: both; FONT-WEIGHT: normal; COLOR: #666 } .MagazinePreviousIssues #MainColumn .Item DT STRONG { FONT-WEIGHT: normal; COLOR: #c33 } .MagazinePreviousIssues #MainColumn .Item DD { FONT-SIZE: 70%; MARGIN: 0px 0px 1em; COLOR: #666 } .MagazinePreviousIssues #MainColumn #page-nav { MARGIN-BOTTOM: 1em; MARGIN-RIGHT: 1em; TEXT-ALIGN: right } .MagazinePreviousIssues #MainColumn #page-nav A { TEXT-DECORATION: underline } .MagazineQuarterlyAuthors { =09 } .MagazineQuarterlyAuthors #MainColumn { MARGIN-LEFT: 10px } .MagazineQuarterlyAuthors #MainColumn H2 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 75%; MARGIN-BOTTOM: 0.8em; PADDING-BOTTOM: = 0px; TEXT-TRANSFORM: uppercase; BORDER-LEFT: medium none; COLOR: #666; = PADDING-TOP: 0px; BORDER-BOTTOM: medium none } .MagazineQuarterlyAuthors #MainColumn H3 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 75%; MARGIN-BOTTOM: 0.5em; PADDING-BOTTOM: = 0px; BORDER-LEFT: medium none; COLOR: #333; PADDING-TOP: 0px; = BORDER-BOTTOM: medium none } .MagazineQuarterlyAuthors #MainColumn .Item { BORDER-TOP: #e0e0e0 1px solid; MARGIN: 10px 0px 0px; PADDING-TOP: 10px } .MagazineQuarterlyAuthors #MainColumn .Item UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .MagazineQuarterlyAuthors #MainColumn .Item UL LI { MARGIN-BOTTOM: 0px; COLOR: #666 } .MagazineQuarterlyAuthors #MainColumn .Item LI A { TEXT-DECORATION: underline } .MyScience { =09 } .MyScience #MainColumn .Item { MARGIN-BOTTOM: 25px } .MyScience #MainColumn .Item H4 { FONT-SIZE: 75%; MARGIN-BOTTOM: 0.7em; PADDING-BOTTOM: 5px; = TEXT-TRANSFORM: uppercase; COLOR: #666; BORDER-BOTTOM: #b9cdd7 1px solid } .MyScience #MainColumn .Item P .Icon { MARGIN-BOTTOM: 2px } .MagazineBarrier { =09 } .MagazineBarrier #MainColumn { MARGIN: 0px 25px } .MagazineBarrier #MainColumn .SCIcon { FLOAT: left; MARGIN-RIGHT: 10px } * HTML .MagazineBarrier #MainColumn { MARGIN: 0px 25px } .MagazineSearch { =09 } .MagazineSearch #MainColumn .HelpText { FONT-SIZE: 70% } .MagazineSearch #MainColumn .HelpText A { TEXT-DECORATION: underline } .MagazineSearch #MainColumn H2 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: 5px; MARGIN: 0px; = BORDER-LEFT: medium none; COLOR: #666; PADDING-TOP: 0px; BORDER-BOTTOM: = medium none } .MagazineSearch #MainColumn .Item { PADDING-RIGHT: 0px; BORDER-TOP: #d9e4e9 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 6px; PADDING-TOP: 6px } .MagazineSearch #MainColumn .Item H3 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 75%; PADDING-BOTTOM: 0px; MARGIN: 0px; = TEXT-TRANSFORM: none; BORDER-LEFT: medium none; COLOR: #333; = PADDING-TOP: 0px; BORDER-BOTTOM: medium none; WHITE-SPACE: nowrap } .MagazineSearch #MainColumn .Item LABEL { FONT-SIZE: 75% } .MagazineSearch #MainColumn .Item .LayoutTable { =09 } .MagazineSearch #MainColumn .Item .LayoutTable TH { VERTICAL-ALIGN: top; PADDING-TOP: 4px; TEXT-ALIGN: left } .MagazineSearch #MainColumn .Item .LayoutTable TD .FormAction { DISPLAY: inline; MARGIN-LEFT: 6px } .MagazineSearch #MainColumn .Item #search_citation_form .TextInput { WIDTH: 30px } .MagazineSearch #MainColumn .Item #search_doi_form .TextInput { WIDTH: 170px } .MagazineSearch #MainColumn .Item .FormTable TH { VERTICAL-ALIGN: top; PADDING-TOP: 5px; TEXT-ALIGN: right } .MagazineSearch #MainColumn .Item .Inputs { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .MagazineSearch #MainColumn .Item .Inputs LI LABEL { FONT-SIZE: 100% } .MagazineSearch #MainColumn .Item H5 { FONT-SIZE: 75%; MARGIN: 1em 0px 0.5em 20px; TEXT-TRANSFORM: uppercase; = COLOR: #333 } .MagazineSearch #MainColumn #search_citation_form .FormAction { MARGIN-LEFT: 15px } .MagazineSearch #MainColumn #search_citation-vol { MARGIN-RIGHT: 10px } * HTML .MagazineSearch #MainColumn #search_citation_form .FormAction { MARGIN-LEFT: 4px } .MagazineSearch #MainColumn FORM FIELDSET .Item P { MARGIN-BOTTOM: 0.5em } .MagazineSearch #MainColumn FORM FIELDSET UL.HorizList { HEIGHT: 1em } .MagazineSearch #MainColumn FORM FIELDSET UL.HorizList LI { MARGIN-RIGHT: 2em } .MagazineSearch #MainColumn #search_keyword_form { =09 } .MagazineSearch #MainColumn #search_keyword_form H3 { MARGIN-BOTTOM: 0.7em } .MagazineSearch #MainColumn #search_keyword_form FIELDSET { PADDING-BOTTOM: 10px } .MagazineSearch #MainColumn #search_keyword_form P { MARGIN: 0.7em 0px 0.7em 20px } .MagazineSearch #MainColumn #search_keyword_form .FormTable { WIDTH: 100% } .MagazineSearch #MainColumn #search_keyword_form .FormTable TH SPAN { DISPLAY: block } .MagazineSearch #MainColumn #search_keyword_form .FormTable TD = .HorizList LI { MARGIN-RIGHT: 10px } .MagazineSearch #MainColumn #search_keyword_form .FormTable TD .Inputs { MARGIN-LEFT: 0px! important } .MagazineSearch #MainColumn #search_keyword_form .FormTable TD .Inputs { MARGIN-TOP: 2px; MARGIN-BOTTOM: 2em } .MagazineSearch #MainColumn #search_keyword_form .FormTable TD = .Exception { MARGIN-BOTTOM: 0px } .MagazineSearch #MainColumn #search_keyword_form .FormTable TD .Inputs = LI.Exception { PADDING-LEFT: 0px } .MagazineSearch #MainColumn #search_keyword_form .FormTable TD .Inputs = .Wrapper { FLOAT: left; TEXT-INDENT: 0px; MARGIN-RIGHT: 10px } .MagazineSearch #MainColumn #search_keyword_form .FormTable TD .Inputs = .Separator { MARGIN: 5px 0px } .MagazineSearch #MainColumn #search_keyword_form .LayoutTable TD .Inputs = { MARGIN-LEFT: 20px } .MagazineSearch #MainColumn #search_keyword_form .LayoutTable TD .Inputs = LI { PADDING-LEFT: 20px; TEXT-INDENT: -20px } .MagazineSearch #MainColumn #search_keyword_form .FormAction { PADDING-BOTTOM: 5px; MARGIN-RIGHT: 5px; BORDER-BOTTOM: #ccc 1px solid; = TEXT-ALIGN: right } .MagazineSearch #MainColumn #search_keyword_form #search_keyword-phrase = { MARGIN-BOTTOM: 25px } .MagazineSearch #MainColumn #search_keyword_form = #search_keyword-author-and { MARGIN-BOTTOM: 25px } * HTML .MagazineSearch #MainColumn #search_keyword_form FIELDSET { PADDING-BOTTOM: 0px } * HTML .MagazineSearch #MainColumn #search_keyword_form .FormTable TD = .HorizList { MARGIN-BOTTOM: 1em! important; PADDING-BOTTOM: 1em } * HTML .MagazineSearch #MainColumn #search_keyword_form .FormTable TD = .Inputs { MARGIN-BOTTOM: 0px } .MagazineSearchResults { =09 } .MagazineSearchResults #MainColumn H2 { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FONT-SIZE: 100%; MARGIN-BOTTOM: 0.5em; = PADDING-BOTTOM: 0px; BORDER-LEFT: medium none; COLOR: #666; PADDING-TOP: = 0px; BORDER-BOTTOM: medium none } .MagazineSearchResults #MainColumn #results-header { MARGIN-BOTTOM: 4px; POSITION: relative } .MagazineSearchResults #MainColumn #results-found { FONT-SIZE: 75%; MARGIN-LEFT: 4px } .MagazineSearchResults #MainColumn #sort-by { FONT-SIZE: 70%; RIGHT: 6px; POSITION: absolute; TOP: 0px } .MagazineSearchResults #MainColumn #sort-by A { TEXT-DECORATION: underline } .MagazineSearchResults #MainColumn .PageNav { CLEAR: left; PADDING-LEFT: 4px; FONT-SIZE: 75%; MARGIN: 1em 0px } .MagazineSearchResults #MainColumn .PageNav A { TEXT-DECORATION: none } .MagazineSearchResults #MainColumn .PageNav SPAN { FONT-WEIGHT: bold } .MagazineSearchResults #MainColumn #query-details-box { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; BORDER-LEFT: #ccc 1px = solid; PADDING-TOP: 2px; BORDER-BOTTOM: medium none; POSITION: relative } .MagazineSearchResults #MainColumn #query-details-box .BorderFix { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #eae9e9; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px } .MagazineSearchResults #MainColumn #query-details-toggle { PADDING-RIGHT: 0px; PADDING-LEFT: 20px; FONT-SIZE: 70%; BACKGROUND: = url(/icons/icon.circle.plus.gif) no-repeat left top; PADDING-BOTTOM: = 3px; PADDING-TOP: 1px } .MagazineSearchResults #MainColumn #query-details { DISPLAY: none; MARGIN: 4px 0px 0px 20px } .MagazineSearchResults #MainColumn #query-details LI { FONT-SIZE: 70% } .MagazineSearchResults #MainColumn #modify-search { FONT-SIZE: 70%; RIGHT: 10px; POSITION: absolute; TOP: 6px; = TEXT-DECORATION: underline } * HTML .MagazineSearchResults #MainColumn #query-details-toggle { PADDING-TOP: 0px } * HTML .MagazineSearchResults #MainColumn #modify-search { TOP: 8px } .MagazineSearchResults #MainColumn .search-tools { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; BORDER-LEFT: #ccc 1px = solid; PADDING-TOP: 2px; BORDER-BOTTOM: #ccc 1px solid } .MagazineSearchResults #MainColumn .search-tools DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: #eae9e9; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 2px } .MagazineSearchResults #MainColumn .search-tools DL { WIDTH: 450px } .MagazineSearchResults #MainColumn .search-tools DL DT { CLEAR: left; PADDING-RIGHT: 4px; PADDING-LEFT: 0px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 2px = 0px; WIDTH: 126px; PADDING-TOP: 2px; WHITE-SPACE: nowrap; TEXT-ALIGN: = right } .MagazineSearchResults #MainColumn .search-tools DL DD { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; FLOAT: left; PADDING-BOTTOM: = 2px; MARGIN: 0px; PADDING-TOP: 2px } .MagazineSearchResults #MainColumn .ArticleList BLOCKQUOTE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 1em = 0px; PADDING-TOP: 0px } .MagazineSearchResults #MainColumn .ArticleList DT { BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 24px; TEXT-INDENT: -24px; = PADDING-TOP: 12px } .MagazineSearchResults #MainColumn .ArticleList DD { PADDING-RIGHT: 10px; PADDING-LEFT: 24px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .MagazineSearchResults #MainColumn .ArticleList DD A SPAN.Highlight { =09 } .MagazineSearchResults #MainColumn .ArticleList SPAN { FONT-WEIGHT: bold; COLOR: #cc3333 } .ScienceExpressHome { =09 } .ScienceExpressHome #NavColumn #Alert { BORDER-RIGHT: #e53f40 1px solid; PADDING-RIGHT: 8px; BORDER-TOP: = #e53f40 1px solid; PADDING-LEFT: 8px; MARGIN-BOTTOM: 0.3em; = PADDING-BOTTOM: 8px; BORDER-LEFT: #e53f40 1px solid; PADDING-TOP: 8px; = BORDER-BOTTOM: #e53f40 1px solid } .ScienceExpressHome #NavColumn #Alert H3 { FONT-SIZE: 75%; COLOR: #c33 } .ScienceExpressHome #NavColumn #Alert P { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px } .ScienceExpressHome #NavColumn #Alert A { WHITE-SPACE: nowrap; TEXT-DECORATION: underline } .ScienceExpressHome #MainColumn { MARGIN-LEFT: 10px; MARGIN-RIGHT: 15px } .ScienceExpressHome #MainColumn H1 { MARGIN-BOTTOM: 5px } 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PADDING-LEFT: 0px; FONT-SIZE: 90%; PADDING-BOTTOM: 0px; MARGIN: 0px; = TEXT-TRANSFORM: none; BORDER-LEFT: medium none; COLOR: #333; = PADDING-TOP: 0px; BORDER-BOTTOM: medium none } .ScienceExpressArticleAbstract #MainColumn H4 { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 1.5em; FONT-SIZE: 75%; = MARGIN-BOTTOM: 0.75em; COLOR: #666; PADDING-TOP: 1em } .ScienceExpressArticleAbstract #MainColumn H4 SPAN { FONT-WEIGHT: normal; TEXT-TRANSFORM: uppercase } .ScienceExpressArticleAbstract #MainColumn H5 { MARGIN-TOP: 1.5em; FONT-SIZE: 75%; COLOR: #c00 } .ScienceExpressArticleAbstract #MainColumn OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .ScienceExpressArticleAbstract #MainColumn OL LI { FONT-WEIGHT: normal } * HTML .ScienceExpressArticleAbstract #MainColumn OL { MARGIN-LEFT: 0.2em } @media Print =20 { #PageWrapper .MagazineTOC #MainColumn { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #PageWrapper .MagazineTOC #table-of-contents .LayoutTable { WIDTH: 100% } } .GeneratedPage #MainColumn { MARGIN-LEFT: 10px; MARGIN-RIGHT: 10px } .GeneratedPage #MainColumn #page-nav { FONT-WEIGHT: 700; FONT-SIZE: 85%; TEXT-ALIGN: right } .GeneratedPage #MainColumn #TopMatter { MARGIN-BOTTOM: 30px } .GeneratedPage #MainColumn #TopMatter H2 { MARGIN-BOTTOM: 0px; COLOR: #333 } .GeneratedPage #MainColumn #TopMatter H2 SPAN { DISPLAY: block; FONT-SIZE: small } .GeneratedPage #MainColumn #IndividualArticles HR { VISIBILITY: hidden! important; MARGIN-BOTTOM: 0px! important } .GeneratedPage #MainColumn #IndividualArticles A { TEXT-DECORATION: underline } .GeneratedPage #MainColumn #IndividualArticles .LinkTop { MARGIN-TOP: 0px; FONT-SIZE: 90%; MARGIN-BOTTOM: 20px } ------=_NextPart_000_0232_01C8B117.A3CBB660 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencemag.org/utils.js // js config object. used to store global vars var CONFIG =3D { img_path : "/icons/" // global path to site image assets }; // = -------------------------------------------------------------------------= ---- // used in search results pages function toggleQueryDetails() { if (!getDomObj('query-details-toggle') || !getDomObj('query-details')) = return; var qd =3D DOM_OBJECTS['query-details']; var qdt =3D DOM_OBJECTS['query-details-toggle']; // default, non-persistent state of page is hidden if ( (qd.style.display =3D=3D 'none') || (qd.style.display =3D=3D '') ) = { qd.style.display =3D 'block'; qdt.style.backgroundImage =3D 'url(' + CONFIG['img_path'] + = 'icon.circle.arrow.dn.gif)'; qdt.innerHTML =3D 'Hide Query Details'; } else { qd.style.display =3D 'none'; qdt.style.backgroundImage =3D 'url(' + CONFIG['img_path'] + = 'icon.circle.plus.gif)'; qdt.innerHTML =3D 'Show Query Details'; } qdt.blur(); } // END: toggleQueryDetails() // = -------------------------------------------------------------------------= ---- function uncheckSelectAll(current_checkbox, checkbox_name) { current_checkbox.form.elements[checkbox_name].checked =3D false; } // END: uncheckSelectAll() function toggleSelectAllInFieldset(checkbox) { // bail out if browser isn't capable of simple DOM methods... // this function is just necessary for the UI to update, anyway if (!document.getElementsByTagName) return; // if we are unchecking the checkbox, then bail out... we don't need to = do anything if (!checkbox.checked) return; var fieldset =3D checkbox.parentNode; var all_checkboxes =3D fieldset.getElementsByTagName('INPUT'); for (var i=3D0; i < all_checkboxes.length; i++) { if ( (all_checkboxes[i] =3D=3D checkbox) || (all_checkboxes[i].title = =3D=3D "Pubmed") ) continue; // if (all_checkboxes[i] =3D=3D checkbox) continue; // all_checkboxes[i].checked =3D checkbox.checked; all_checkboxes[i].checked =3D false; } } // END: toggleSelectAllInFieldset() // = -------------------------------------------------------------------------= ---- // attach this to the onfocus of an INPUT or TEXTAREA, passing the = 'this' object as the argument function textFieldStoreAndClear(el) { el.originalText =3D (el.originalText =3D=3D null) ? el.value : = el.originalText; if (el.value =3D=3D el.originalText) el.value =3D ''; } // attach this to the onblur of an INPUT or TEXTAREA, passing the 'this' = object as the argument function textFieldRestore(el) { el.value =3D (el.value =3D=3D '') ? el.originalText : el.value; } // takes title attribute from INPUTs with .ShowTitle and sticks it in = the value attrib. addWindowEvent('onload', function(){ if (!document.getElementById) return; var all_inputs =3D document.getElementsByTagName('INPUT'); var temp_class =3D ""; for (var i=3D0; i < all_inputs.length; i++) { temp_class =3D " " + all_inputs[i].className; if (temp_class =3D=3D " ") continue; if ( (temp_class.indexOf(" ShowTitle") > 0) && (all_inputs[i].value = =3D=3D "") ) { all_inputs[i].value =3D all_inputs[i].title; all_inputs[i].onfocus =3D function() { textFieldStoreAndClear(this) = }; all_inputs[i].onblur =3D function() { textFieldRestore(this) }; } temp_class =3D ""; } }); // = -------------------------------------------------------------------------= ---- var DOM_OBJECTS =3D []; // hash to store frequently used DOM objects // utility function to get DOM objects function getDomObj(object_name) { // bail out if browser is not capable if (!document.getElementById) return false; // return true if object was already fetched if (DOM_OBJECTS[object_name]) return true; // get the object and return the result of the get return (DOM_OBJECTS[object_name] =3D = document.getElementById(object_name)) ? true : false; } // END: getDomObj // = -------------------------------------------------------------------------= ---- // extension of an idea from simon willison // http://simon.incutio.com/archive/2004/05/26/addLoadEvent // adds function call to an arbitrary window event trigger function addWindowEvent(event_name, function_to_add) { var current_event =3D window[event_name]; if (typeof(current_event) !=3D 'function') { window[event_name] =3D function_to_add; } else { window[event_name] =3D function() { current_event(); function_to_add(); }; } } // END: addWindowEvent() // = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D var DEBUG =3D true; var DEBUG_MESSAGE_TYPES =3D ["ERROR", "WARNING", 'STATUS']; var debug_win; function debug(message_type, message) { if (DEBUG && (DEBUG_MESSAGE_TYPES.join(" ").indexOf(message_type) > -1 = )) { if (!debug_win) { debug_win =3D window.open("","",""); debug_win.document.open(); } message =3D message.replace(//g, ">"); =09 try { debug_win.document.write(""); } catch(e) { debug_win =3D window.open("","",""); debug_win.document.open(); =09 } debug_win.document.write("

" + message_type + "

"); debug_win.document.write("
" + message + "
"); } } // END: debug() /* Simple client-side validation of the My Directory Entries form for = STKE. Batch-mode only. Adapted by SW from several sources (including JS and DHTML Cookbook, = O'Reilly, 2003), 2006/08/09 */=20 // Routine to validate that a text field has at least a character or two function isNotEmpty(elem) { var str =3D elem.value; if(str =3D=3D null || str.length =3D=3D 0) { return false; } else { return true; } } // Routine to validate that a pull-down selection has been made function isChosen(select) { if (select.selectedIndex =3D=3D 0) { return false; } else { return true; } } /* Batch-mode validation of the specific entries to be validated in the = My Directory Entries form. Fields that are supposed to be completed and are not are highlighted in = yellow, and the user gets an alert asking for full info. Very ugly series of if-statements, = but it works. */=20 function validateDirForm(form) { var fn =3D ""; var sn =3D ""; var ps =3D ""; var inst =3D ""; var wr =3D ""; if (isNotEmpty(form.firstname)) { if (isNotEmpty(form.lastname)) { if (isChosen(form.position)){ if (isNotEmpty(form.institution_1)) { if (isChosen(form.world_region_id)){ return true; } } } }=20 } if (!isNotEmpty(form.firstname)){ form.firstname.style.backgroundColor =3D "#ffffdd"; fn =3D "First Name\n";} else { form.firstname.style.backgroundColor =3D "#ffffff";} if (!isNotEmpty(form.lastname)){ form.lastname.style.backgroundColor =3D "#ffffdd"; sn =3D "Last Name\n";} else { form.lastname.style.backgroundColor =3D "#ffffff";} if (!isChosen(form.position)){ form.position.style.backgroundColor =3D "#ffffdd"; ps =3D "Position\n";} else { form.position.style.backgroundColor =3D "#ffffff";} if (!isNotEmpty(form.institution_1)){ form.institution_1.style.backgroundColor =3D "#ffffdd"; form.institution_2.style.backgroundColor =3D "#ffffdd"; inst =3D "Institution\n";} else { form.institution_1.style.backgroundColor =3D "#ffffff"; form.institution_2.style.backgroundColor =3D "#ffffff";} if (!isChosen(form.world_region_id)){ form.world_region_id.style.backgroundColor =3D "#ffffdd"; wr =3D "World Region\n";} else { form.world_region_id.style.backgroundColor =3D "#ffffff";} alert("We ask that your directory information include at least the = following: First Name, Last Name, Position, Institution, and World = Region.\n\nPlease provide responses for:\n" + fn + sn + ps + inst + wr); return false; } //End of validation script //--------------cookie stuff function setCookie (name, value, expires, path, domain, secure) { document.cookie =3D name + "=3D" + escape(value) + ((expires) ? "; expires=3D" + expires : "") + ((path) ? "; path=3D" + path : "") + ((domain) ? "; domain=3D" + domain : "") + ((secure) ? "; secure" : ""); } function getCookie(name) { var cookie =3D " " + document.cookie; var search =3D " " + name + "=3D"; var setStr =3D null; var offset =3D 0; var end =3D 0; if (cookie.length > 0) { offset =3D cookie.indexOf(search); if (offset !=3D -1) { offset +=3D search.length; end =3D cookie.indexOf(";", offset) if (end =3D=3D -1) { end =3D cookie.length; } setStr =3D unescape(cookie.substring(offset, = end)); } } return(setStr); } function survey_popup () { var survey_popup =3D getCookie('survey_popup'); if (survey_popup =3D=3D null) { setCookie("survey_popup", "true", "", "/"); window.open("http://www.sciencemag.org/marketing/ed_survey/ed_survey.dtl"= , 'surveypop', 'toolbar=3D0, location=3D0, directories=3D0, menuBar=3D0, = resizable=3D1, width=3D425, height=3D475, left=3D50, top=3D50'); } } =20 //end cookies /***********institutional user pop up******************/ function inst_popup () { var inst_popup =3D getCookie('inst_popup'); if (inst_popup =3D=3D null) { setCookie("inst_popup", "true", "Tue, 14 Apr 2009 = 02:04:57 GMT", "/");=09 window.open("http://www.sciencemag.org/inst_popup.dtl", 'instpopup', = 'toolbar=3D0, location=3D0, directories=3D0, menuBar=3D0, = resizable=3D1, width=3D575, height=3D500, left=3D50, top=3D50'); } } /* Miscellaneous routines to toggle styles and text for specific IDs */ function toggleElement(id){=20 if(!document.getElementById) return; var elem =3D document.getElementById(id); elem.style.display =3D (elem.style.display =3D=3D 'block') ? 'none' = : 'block'; } function toggleWeight(id2){=20 if(!document.getElementById) return; var elem2 =3D document.getElementById(id2); elem2.style.fontWeight =3D (elem2.style.fontWeight =3D=3D '400') ? = '700' : '400'; } function toggleBckImg(id3,img1,img2){=20 if(!document.getElementById) return; var elem3 =3D document.getElementById(id3); elem3.style.backgroundImage =3D (elem3.style.backgroundImage =3D=3D = 'url(' + img1 + ')') ? 'url(' + img2 + ')' : 'url(' + img1 + ')'; } function toggleStyle(id4,stylename,val1,val2){=20 if(!document.getElementById) return; var elem4 =3D document.getElementById(id4); elem4.style[stylename] =3D (elem4.style[stylename] =3D=3D val1) ? = val2 : val1 ; } =20 function switchText(id5,val1,val2){=20 if(!document.getElementById) return; var elem5 =3D document.getElementById(id5); elem5.innerHTML =3D (elem5.innerHTML =3D=3D val1) ? val2 : val1 ; } =09 /* Image resize toggle for ScienceNOW */ function SNOWImageResize() { toggleStyle('PhotoForExp', 'width', '450px', '190px'); toggleBckImg('ResizeImage', '/icons/blueminus.gif', = '/icons/blueplus.gif'); switchText('RItext', 'Enlarge Image', 'Reduce Image Size'); } /* sciLoadExtText -- simple AJAX routine for pulling HTML from external = source into a designated DIV without page reload */ function sciLoadExtText(url,docid) { var req =3D new XMLHttpRequest(); if (req) { req.onreadystatechange =3D function() { if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || = req.status =3D=3D 304)) { var sciswitch =3D document.getElementById(docid); var sciswitchval =3D sciswitch.innerHTML; if (sciswitchval =3D=3D ''){ sciswitch.style.display =3D "block"; sciswitch.innerHTML =3D req.responseText; } else { sciswitch.style.display=3D"inline"; sciswitch.innerHTML =3D ''; } } }; req.open('GET', url); req.send(null); } } ------=_NextPart_000_0232_01C8B117.A3CBB660 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencemag.org/javascript/ajax/xmlhttprequest.js /*=0A= =0A= Cross-Browser XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_0232_01C8B117.A3CBB660 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencemag.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else 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