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Overall Management > Astrocytic
Tumors
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Arch
Pathol Lab Med. 2007
Mar;131(3):397-406
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Abstract |
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Glioblastoma. Morphologic
and Molecular Genetic Diversity
C. Ryan Miller, MD, PhD; Arie Perry, MD
From the Division of Neuropathology,
Washington University School of Medicine, St Louis, Mo -- Accepted
October 25, 2006
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Context.
Glioblastoma (GBM), the most common primary intracranial malignancy,
is a morphologically diverse neoplasm with dismal prognosis despite
multimodality therapy.
Only 3 distinct morphologic variants of
GBM are currently recognized by the current World Health Organization
classification scheme, including GBM, giant cell GBM, and gliosarcoma.
Additional variants, some of which have
significant morphologic overlap with tumors that have more favorable
prognosis and treatment response rates, particularly anaplastic
oligodendroglioma, have been described since its publication in 2000
and may be included in the next classification.
Objective.
To summarize the morphologic and molecular genetic diversity of both
well-established and novel GBM variants and outline our approach to
these heterogeneous neoplasms and their distinction from other
diffuse, high-grade gliomas.
Data Sources. Published
literature and our own experience in an active academic diagnostic
surgical neuropathology practice were reviewed.
Conclusions. Precise
subclassification of GBM is required for accurate prognostication and
appropriate treatment planning.
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© Copyright by College of American
Pathologists 2007
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Abstract |
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