From: Subject: Mining gene expression profiles: expression signatures as cancer phenotypes : Abstract : Nature Reviews Genetics Date: Fri, 9 May 2008 18:42:03 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_011E_01C8B204.5FC97270" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_011E_01C8B204.5FC97270 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nrg/journal/v8/n8/abs/nrg2137.html Mining gene = expression profiles: expression signatures as cancer phenotypes : = Abstract : Nature Reviews Genetics

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Nature Reviews Genetics = 8, 601-609 = (August 2007) | = doi:10.1038/nrg2137

Mining gene expression profiles: expression signatures as = cancer=20 phenotypes

Joseph R. Nevins1=20 & Anil Potti1 =20 Abo= ut the=20 authors

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Abstract

Many examples highlight the power of gene expression = profiles, or=20 signatures, to inform an understanding of biological phenotypes. This is = perhaps=20 best seen in the context of cancer, where expression signatures have = tremendous=20 power to identify new subtypes and to predict clinical outcomes. = Although the=20 ability to interpret the meaning of the individual genes in these = signatures=20 remains a challenge, this does not diminish the power of the signature = to=20 characterize biological states. The use of these signatures as surrogate = phenotypes has been particularly important, linking diverse experimental = systems=20 that dissect the complexity of biological systems with the in=20 vivo setting in a way that was not previously feasible.

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Author affiliations

  1. Duke Institute for Genome Sciences and Policy, Duke = University=20 Medical Center, Durham, North Carolina 27710, USA.

Correspondence to: Joseph R. Nevins1=20 Email: nevin001@mc.duke.edu=20

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DIV.container-plugins { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { BORDER-BOTTOM-WIDTH: 0px } #article-related DIV.wrapper { MARGIN-BOTTOM: 10px } #article-related P.explain { FONT-SIZE: 70%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P.last { MARGIN: 0px } #article-related P.results { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related A.article { DISPLAY: block; FONT-WEIGHT: 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#foot-er #footer-links UL LI A:link { DISPLAY: inline } * HTML #foot-er #footer-links UL LI A:visited { DISPLAY: inline } #foot-er #footer-links UL LI A:hover { TEXT-DECORATION: underline } #foot-er #footer-links UL LI A.about-npg:link { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-links UL LI A.about-npg:visited { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-copyright { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left! important } * HTML #foot-er #footer-copyright .footer-constrain { TEXT-ALIGN: left } #foot-er #footer-copyright A { COLOR: #b1062e } #foot-er #footer-copyright P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 5px } #foot-er #footer-copyright P.logo { PADDING-RIGHT: 36px; PADDING-LEFT: 36px; BACKGROUND: = url(/common/images/npg_logo.gif) no-repeat 0px 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