From: Subject: Blackwell Synergy - J Cellular Mol Med, OnlineAccepted Articles (Article Abstract) Date: Tue, 26 Feb 2008 18:03:22 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_00C0_01C878A1.E04141E0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_00C0_01C878A1.E04141E0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1582-4934.2007.00151.x =EF=BB=BF Blackwell Synergy - = J Cellular Mol Med, OnlineAccepted Articles (Article Abstract)
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Publication history

Accepted article online:
20 Nov 2007

Received 15 June 2007, accepted 25 october=20 2007

3D"Journal=20

Journal of Cellular and Molecular = Medicine

OnlineAccepted Articles (Accepted, unedited = articles or=20 abstracts published online for future issues)

To cite this article: Nathan D. Price, Greg Foltz, = Anup=20 Madan, Leroy Hood, Qiang Tian (2007)
Systems Biology and Cancer Stem = Cells=20
doi:10.1111/j.1582-4934.2007.00151.x
(Online Accepted)

 Free Content

Abstract

Systems Biology and Cancer Stem Cells

  • 1Institute for Systems = Biology,=20 Seattle, WA 2Seattle = Neuroscience=20 Institute, Swedish Medical Center, Seattle, WA =
*To = whom=20 correspondence should be addressed: qtian@systemsbiology.org
= Qiang=20 Tian, M.D., Ph.D.
Institute for Systems Biology
1441 N. = 34th=20 St.
Seattle, WA 98103

3Department of Chemical and = Biomolecular=20 Engineering & Institute for Genomic Biology, University of Illinois, = Urbana-Champaign

Abstract

 

The identification, purification, and characterization = of cancer=20 stem cells holds tremendous promise for improving the treatment of = cancer.=20 Mounting evidence is demonstrating that only certain tumor cells (i.e. = the=20 cancer stem cells) can give rise to tumors when injected and that these = purified=20 cell populations generate heterogeneous tumors. While the cell of origin = is=20 still not determined definitively, specific molecular markers for = populations=20 containing these cancer stem cells have been found for leukemia, brain = cancer,=20 and breast cancer, among others. Systems approaches, particularly = molecular=20 profiling, have proven to be of great utility for cancer diagnosis and=20 characterization. These approaches also hold significant promise for = identifying=20 distinctive properties of the cancer stem cells, and progress is already = being=20 made.


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(elem=3Ddocument.getElementById(eid)))=0A= elem.style.color=3Dcolor;=0A= }=0A= =0A= /**=0A= * Shorthand for id'ing elements=0A= */=0A= if (typeof $ =3D=3D "undefined") $ =3D function(id) { return = document.getElementById(id); } // do not override if already defined = by prototype=0A= =0A= /** ccc rights link */=0A= function RightslinkPopUp(aPublisher, aPublication, aTitle, aDate, = aAuthor, aContentId, aCopyright, aVolume, aIssue, aStartPage, aEndPage, = aIssn, aOrderBeanReset, aColor)=0A= {=0A= var location =3D=0A= "?publisherName=3D" + aPublisher=0A= + "&publication=3D" + aPublication=0A= + "&title=3D" + aTitle=0A= + "&publicationDate=3D" + aDate=0A= + "&author=3D" + aAuthor=0A= + "&contentID=3D" + aContentId=0A= + "©right=3D" + aCopyright=0A= + "&startPage=3D" + aStartPage=0A= + "&endPage=3D" + aEndPage;=0A= if (aVolume !=3D null) {=0A= location +=3D "&volumeNum=3D" + aVolume;=0A= }=0A= if (aIssue !=3D null) {=0A= location +=3D "&issueNum=3D" + aIssue;=0A= }=0A= if (aIssn !=3D null) {=0A= location +=3D "&issn=3D" + aIssn;=0A= }=0A= if (aOrderBeanReset !=3D null) {=0A= location +=3D "&orderBeanReset=3D" + aOrderBeanReset;=0A= }=0A= if (aColor !=3D null){=0A= location +=3D "&color=3D" + aColor;=0A= }=0A= =0A= var link =3D "/servlet/linkout?type=3Drightslink&url=3D" + = escape(location);=0A= var winprops =3D = "location=3Dno,toolbar=3Dno,directories=3Dno,status=3Dno,menubar=3Dno,scr= ollbars=3Dyes,resizable=3Dyes,width=3D650,height=3D550";=0A= PopUp =3D window.open(link, 'Rightslink', winprops);=0A= }=0A= =0A= =0A= /* Function to load images.=0A= * note: make this empty method so that=0A= * 1) mininize code changes; 2) for future integration; 3) easier to = take the feature back=0A= */=0A= function MM_preloadImages() {=0A= }=0A= =0A= function MM_swapImgRestore() {=0A= }=0A= =0A= function MM_findObj(n, d) {=0A= }=0A= =0A= function MM_swapImage() {=0A= }=0A= =0A= function menuMouseOver(type, actualType) {=0A= = document.getElementById('MenuItem_'+type).className=3D'MenuItemOver_'+(ty= pe =3D=3D actualType);=0A= }=0A= function menuMouseOut(type, actualType) {=0A= = document.getElementById('MenuItem_'+type).className=3D'MenuItem_'+(type = =3D=3D actualType);=0A= }=0A= function menuClick(type) {=0A= document.getElementById('MenuLink_'+type).click();=0A= }=0A= =0A= // browser detection=0A= function browserCheck() {=0A= this.ns4 =3D (document.layers)? true:false;=0A= this.ie =3D (document.all&&(!window.opera))? true:false;=0A= this.dom =3D (document.getElementById)? true:false;=0A= this.ns6 =3D (window.sidebar)? true:false;=0A= this.moz =3D = (window.sidebar||navigator.userAgent.indexOf('Gecko')!=3D-1)? true:false;=0A= this.opera =3D (window.opera)? true:false;=0A= this.mac =3D (navigator.userAgent.indexOf('Mac')!=3D-1)? true:false;=0A= }=0A= browser =3D new browserCheck();=0A= var Obj;=0A= =0A= // multibrowser get object by id, in NN4 you cannot access all object = (test it first)=0A= function getObjectByName(nameOfObject){=0A= Obj =3D null;=0A= if (browser.ie) Obj =3D document.all[nameOfObject]=0A= else if (browser.dom) Obj =3D findDOMObject(nameOfObject)=0A= else if (browser.ns4) findLayer(window,nameOfObject);=0A= return (!Obj || ( browser.ns4 && Obj =3D=3D window ) ) ? "Object not = found" : Obj;=0A= }=0A= // helper function=0A= function findDOMObject(nameOfObject) {=0A= for (var i =3D 0; i < document.images.length; i++) {=0A= if (document.images[i].name=3D=3DnameOfObject) return = document.images[i]=0A= }=0A= return document.getElementById(nameOfObject)=0A= }=0A= // helper function=0A= function findLayer(node,nameOfObject) {=0A= if ( node.name =3D=3D nameOfObject ) Obj =3D node;=0A= for ( var counter =3D 0; counter < node.document.images.length; = counter++ ) {=0A= if (node.document.images[counter].name=3D=3DnameOfObject) Obj =3D = node.document.images[counter];=0A= }=0A= for ( var i =3D 0; i < node.document.layers.length; i++ ) {=0A= findLayer(node.document.layers[i],nameOfObject);=0A= }=0A= }=0A= =0A= function toggleVisibility(id) {=0A= obj =3D getObjectByName(id);=0A= if (obj) {=0A= v =3D obj.style.display;=0A= obj.style.display =3D (v =3D=3D 'none') ? 'block' : 'none';=0A= i =3D getObjectByName('hiddenImage');=0A= if(i) i.src =3D '/page/imageHack.jsp?object=3D' + id + = '&display=3D' + obj.style.display + '&dummy=3D' + (new Date()).getTime();=0A= }=0A= }=0A= =0A= /** CSS class support */=0A= /** return true if removed, false if not found */=0A= function removeClass(el, className) {=0A= if (!(el && el.className)) return false;=0A= var cls =3D el.className.split(" ");=0A= var ar =3D new Array();=0A= for (var i =3D cls.length; i > 0;) if (cls[--i] !=3D className) = ar[ar.length] =3D cls[i];=0A= el.className =3D ar.join(" ");=0A= return cls.length !=3D ar.length;=0A= }=0A= /** return true if element has that class */=0A= function hasClass(el, className) {=0A= if (!(el && el.className)) return false;=0A= var cls =3D el.className.split(" ");=0A= for (var i =3D cls.length; i > 0;) if (cls[--i] =3D=3D className) = return true;=0A= return false;=0A= }=0A= /** add class to element, if element already had that class - does = nothink */=0A= function addClass(el, className) {=0A= if (!el || hasClass(el, className)) return;=0A= if (el.className) el.className +=3D " " + className;=0A= else el.className =3D className;=0A= }=0A= /** Add CSS rule as last rule in last stylesheet - override all previous = definitions=0A= removing is harder - not implemented, use it with caution */=0A= function addCssRule(selector, rule) {=0A= if (document.styleSheets) {=0A= var css =3D document.styleSheets[document.styleSheets.length-1]; = // get last css=0A= if (css.addRule) css.addRule(selector, rule); // IE=0A= else if (css.insertRule) css.insertRule(selector + "{" + rule + = "}", css.cssRules.length); // W3C=0A= }=0A= }=0A= /** get CSS style of the document */=0A= function getCssText() {=0A= var imports =3D "";=0A= var cssText =3D "\n";=0A= var styleSheets =3D document.styleSheets;=0A= for (var i =3D 0; i < styleSheets.length; i++) {=0A= var css =3D styleSheets.item(i);=0A= var mediaText =3D typeof css.media =3D=3D "string" ? css.media : = css.media.mediaText;=0A= if (!mediaText || mediaText.indexOf("all") !=3D -1 || = mediaText.indexOf("screen") !=3D -1) {=0A= if (css.imports) {=0A= // IE imports=0A= for (var j =3D 0; j < css.imports.length; j++) {=0A= var href =3D css.imports[j].href;=0A= var lastQuote =3D href.lastIndexOf('"');=0A= if (lastQuote !=3D -1) {=0A= // href contains media - "url" media=0A= mediaText =3D href.substr(lastQuote + 1);=0A= if (mediaText.indexOf("all") =3D=3D -1 && = mediaText.indexOf("screen") =3D=3D -1) continue;=0A= href =3D href.substr(1, lastQuote - 1);=0A= }=0A= imports +=3D '@import url("' + href + '");\n';=0A= }=0A= }=0A= if (css.rules) {=0A= // IE rules=0A= for (var j =3D 0; j < css.rules.length; j++) {=0A= // How to filter media rules ???=0A= cssText +=3D css.rules[j].selectorText + " { " + = css.rules[j].style.cssText + " }\n";=0A= }=0A= } else if (css.cssRules) {=0A= // W3C compliant browser=0A= for (var j =3D 0; j < css.cssRules.length; j++) {=0A= var rule =3D css.cssRules.item(j);=0A= if (rule.type =3D=3D rule.IMPORT_RULE || rule.type =3D=3D = rule.MEDIA_RULE) {=0A= mediaText =3D rule.media.mediaText;=0A= if (mediaText && mediaText.indexOf("all") =3D=3D -1 && = mediaText.indexOf("screen") =3D=3D -1) continue;=0A= if (rule.type =3D=3D rule.IMPORT_RULE) imports +=3D = rule.cssText;=0A= else cssText +=3D rule.cssText + "\n";=0A= } else {=0A= cssText +=3D rule.cssText + "\n";=0A= }=0A= }=0A= }=0A= }=0A= }=0A= return imports + cssText;=0A= }=0A= =0A= function loadCss(url, title, media) {=0A= var el =3D document.createElement('link');=0A= el.type =3D 'text/css';=0A= el.rel =3D 'stylesheet';=0A= el.href =3D url;=0A= el.media =3D media || 'screen';=0A= el.title =3D title || 'dynamicLoadedSheet';=0A= document.getElementsByTagName("head")[0].appendChild(el);=0A= }=0A= =0A= function loadJs(url) { =0A= var el =3D document.createElement("script");=0A= el.type =3D "text/javascript";=0A= el.src =3D url;=0A= document.getElementsByTagName("head")[0].appendChild(el);=0A= }=0A= =0A= /** DOM Event support */=0A= /** addEventListener method may already exist, it's not trivial = implement it and not break it, use other mame 'addListener' is simple */=0A= function addListener(el, evname, func) {=0A= if (el.attachEvent) el.attachEvent("on" + evname, func);=0A= else if(el.addEventListener) el.addEventListener(evname, func, true);=0A= }=0A= /** removeEventListener */=0A= function removeListener(el, evname, func) {=0A= if (el.detachEvent) el.detachEvent("on" + evname, func);=0A= else if (el.removeEventListener) el.removeEventListener(evname, func, = true);=0A= }=0A= =0A= /** Server session access */=0A= /** helper method to access session object */=0A= function _getSession() {=0A= return window.session ? window.session : (window.session =3D new = Array());=0A= }=0A= /** send request to server to preserve some value between different = requests, value is accessible using getSessionAttribute */=0A= function setSessionAttribute(name, value) {=0A= /* just to test callback */=0A= function test(doc) {=0A= // alert("Server returned: " + doc.body.innerHTML);=0A= }=0A= = sendServerMsg("/action/sessionAccess?action=3DsetJavaScriptAttribute&name= =3D" + name + "&value=3D" + value, test);=0A= _getSession()[name] =3D value;=0A= }=0A= /** see setSessionAttribute */=0A= function getSessionAttribute(name) {=0A= return _getSession()[name];=0A= }=0A= =0A= /** send request - url - to the server, response is accessible in = document passed to callback function=0A= DO NOT Send anything before page is loaded!=0A= */=0A= function sendServerMsg(url, callBack) {=0A= /* called when frame is loaded */=0A= function _receiveServerResponse(ev) {=0A= var iFrame =3D window.event ? window.event.srcElement : = ev.currentTarget; // IE : W3C=0A= var doc =3D iFrame.contentDocument ? iFrame.contentDocument : = document.frames(iFrame.id).document; // W3C : IE=0A= if (iFrame.callBack) iFrame.callBack(doc);=0A= document.body.removeChild(document.getElementById(iFrame.id));=0A= }=0A= =0A= var iFrame =3D document.createElement('iframe');=0A= addListener(iFrame, "load", _receiveServerResponse);=0A= iFrame.setAttribute("id", "msgFrame" + new Date().getTime()); // = so IE can retrive document=0A= iFrame.setAttribute("src", url);=0A= iFrame.setAttribute("style", "display:none");=0A= if (callBack) iFrame.callBack =3D callBack;=0A= document.body.appendChild(iFrame);=0A= }=0A= =0A= /**=0A= copy innerHTML of src element to innerHTML of target element=0A= */=0A= function copyInnerHtml(src, target) {=0A= var domSupported =3D document.getElementById ? true : false;=0A= var se =3D (domSupported && typeof src =3D=3D "string") ? = document.getElementById(src) : src;=0A= var te =3D (domSupported && typeof target =3D=3D "string") ? = document.getElementById(target) : target;=0A= if (se.innerHTML && te.innerHTML) te.innerHTML =3D se.innerHTML;=0A= }=0A= /**=0A= filter select options, options that do not contain filter text are = removed=0A= in first use, original select options are backed up as attribute = optionsCopy=0A= */=0A= function filterSelect(selectId, value) {=0A= var select;=0A= if (document.getElementById && (select =3D = document.getElementById(selectId)) && select.options) {=0A= if (!select.optionsCopy) {=0A= select.optionsCopy =3D new Array();=0A= select.optionTexts =3D new Array();=0A= for (var i=3D0; i'+document.title+'');=0A= tmp.writeln(el.innerHTML);=0A= tmp.writeln('');=0A= tmp.close();=0A= }=0A= if (anchor) {=0A= var target =3D (tmp.getElementById) ? = tmp.getElementById(anchor) :=0A= (tmp.all) ? tmp.all[anchor] : false;=0A= if (target) {=0A= if (target.scrollIntoView) target.scrollIntoView();=0A= else if (window.scroll && target.offsetTop) = el.popupWindow.scroll(0, target.offsetTop);=0A= }=0A= }=0A= }=0A= }=0A= =0A= /** marks all check box */=0A= function markAllCheckboxes(aForm, aNamePrefix, aChecked)=0A= {=0A= var elmts =3D aForm.elements;=0A= for (var i=3D0; i 0);=0A= if (addElmt)=0A= url +=3D "&" + elmts[i].name + "=3D" + elmts[i].value;=0A= }=0A= window.location =3D url;=0A= }=0A= }=0A= =0A= /**=0A= * @param aAuthorArray array stores all authors=0A= * @param aKeywordArray array stores all keywords=0A= */=0A= function getAuthorsAndKeywords(aForm, aAuthorArray, aKeywordArray, = aForceAdd)=0A= {=0A= setCheckWhenDefine(aForm.sauthusercbx, true);=0A= setCheckWhenDefine(aForm.keyusercbx, true);=0A= =0A= var elements =3D aForm.elements;=0A= var cntAuthor =3D -1;=0A= var cntKeyword =3D -1;=0A= for (var i=3D0; i0) || (aKeywords.length>0))=0A= {=0A= pmurl =3D = "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dopt=3DDocSum&cmd=3DSearch= &db=3DPubMed&term=3D";=0A= =0A= for (var i=3D0; i0) && (aKeywords.length>0)) {=0A= pmurl +=3D "+OR+";=0A= }=0A= =0A= for (var i=3D0; i0) || (aKeywords.length>0))=0A= {=0A= adsurl =3D=0A= "http://adsabs.harvard.edu/cgi-bin/nph-abs_connect?db_key=3DAST" +=0A= "&sort=3DSCORE&ttl_syn=3DYES&version=3D1" +=0A= "&txt_syn=3DYES&txt_logic=3DAND" +=0A= "&aut_syn=3DYES&aut_logic=3DAND";=0A= =0A= if (aAuthors.length > 0) {=0A= adsurl +=3D "&author=3D";=0A= for (var i=3D0; i 0) {=0A= adsurl +=3D "&text=3D";=0A= for (var i=3D0; i0) || (aKeywords.length>0))=0A= {=0A= var array =3D [aAuthors, aKeywords];=0A= for (var i=3D0; i