From: Subject: Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma -- Beier et al. 68 (14): 5706 -- Cancer Research Date: Mon, 28 Jul 2008 18:37:20 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C8F0E0.F843C2B0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://cancerres.aacrjournals.org/cgi/content/abstract/68/14/5706 Temozolomide Preferentially Depletes Cancer Stem = Cells in Glioblastoma -- Beier et al. 68 (14): 5706 -- Cancer = Research 3D"Cancer 3D"
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF=20 CONTENTS
Cancer = Research Clinical Cancer=20 Research
Cancer=20 Epidemiology Biomarkers & Prevention Molecular=20 Cancer Therapeutics
Molecular=20 Cancer Research Cancer Prevention = Research
Cancer Prevention = Journals=20 Portal Cancer=20 Reviews Online
Annual Meeting = Education=20 Book Meeting=20 Abstracts Online
Cancer Research 68, 5706-5715, July 15, 2008. = doi:=20 10.1158/0008-5472.CAN-07-6878
=A9 2008 American = Association=20 for Cancer Research
This = Article
3D"
3D"Right Fu= ll=20 Text
3D"Right Full=20 Text (PDF)
3D"Right Supplementary=20 Data
3D"Right Alert=20 me when this article is cited
3D"Right Alert=20 me if a correction is posted
3D"
Services
3D"
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in PubMed
3D"Right Alert me to=20 new issues of the journal
3D"Right Download=20 to citation manager
3D"Right 3D"reprints
3D"
Google = Scholar
3D"
3D"Right Articles by Beier, D. =
3D"Right Articles by Beier, C. P. =
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Beier, D. =
3D"Right Articles by Beier, C. P.=20

Cell, Tumor, and Stem Cell = Biology

Temozolomide Preferentially Depletes Cancer Stem Cells in=20 Glioblastoma

Dagmar Beier1,=20 Stefanie R=F6hrl1, Deepu R.=20 Pillai1, Stefanie Schwarz1,=20 Leoni A. Kunz-Schughart3, Petra=20 Leukel1, Martin Proescholdt2,=20 Alexander Brawanski2, Ulrich=20 Bogdahn1, Ariane = Trampe-Kieslich4,=20 Bernd Giebel5, J=F6rg = Wischhusen6,=20 Guido Reifenberger4, Peter = Hau1=20 and Christoph P. Beier1

Departments of 1 Neurology and = 2=20 Neurosurgery, University of Regensburg, Medical School, Regensburg, = Germany;=20 3 ZIK OncoRay, Center for Radiation Research in Oncology, = Dresden,=20 Germany; 4 Department of Neuropathology, = Heinrich-Heine-University,=20 Medical School and 5 Institute of Transplantation Diagnostics = and=20 Cell Therapeutics, Heinrich-Heine-University, D=FCsseldorf, Germany; and = 6 Interdisciplinary Center for Clinical Research, Junior = Research=20 Group "Tumor Progression and Immune Escape," University of W=FCrzburg, = Medical=20 School, Clinics for Gynecology and Obstetrics, W=FCrzburg, Germany =

Requests for reprints: Christoph P. Beier, = Department of=20 Neurology, University of Regensburg, Universit=E4tsstrasse 84, 93053 = Regensburg,=20 Germany. Phone: 49-941-941-3258; Fax: 49-941-941-3292; E-mail: Christoph.Beier{at}gmx.de .

Key Words: cancer stem cell =95 glioblastoma =95 = CD133 =95=20 temozolomide

The prognosis of patients suffering from glioblastoma = (GBM)=20 is dismal despite multimodal therapy. Although chemotherapy=20 with temozolomide may contain tumor growth for some months,=20 invariable tumor recurrence suggests that cancer stem cells=20 (CSC) maintaining these tumors persist. We have therefore=20 investigated the effect of temozolomide on CD133+ = and=20 CD133=96 GBM CSC lines. Although differentiated = tumor cells=20 constituting the bulk of all tumor cells were resistant to = the=20 cytotoxic effects of the substance, temozolomide induced a = dose- and=20 time-dependent decline of the stem cell subpopulation. = Incubation=20 with sublethal concentrations of temozolomide for 2 days = completely=20 depleted clonogenic tumor cells in vitro and = substantially=20 reduced tumorigenicity in vivo. In=20 O6-methylguanine-DNA-methyltransferase = (MGMT)=96expressing=20 CSC lines, this effect occurred at 10-fold higher doses = compared=20 with MGMT-negative CSC lines. Thus, temozolomide = concentrations=20 that are reached in patients were only sufficient to = completely=20 eliminate CSC in vitro from MGMT-negative but not from=20 MGMT-positive tumors. Accordingly, our data strongly suggest = that=20 optimized temozolomide-based chemotherapeutic protocols might = substantially improve the elimination of GBM stem cells and=20 consequently prolong the survival of patients. [Cancer Res=20 2008;68(14):5706=9615]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF=20 CONTENTS
Cancer = Research Clinical Cancer=20 Research
Cancer=20 Epidemiology Biomarkers & Prevention Molecular=20 Cancer Therapeutics
Molecular=20 Cancer Research Cancer Prevention = Research
Cancer Prevention = Journals=20 Portal Cancer=20 Reviews Online
Annual Meeting = Education=20 Book Meeting=20 Abstracts Online
Copyright =A9 2008 by the American Association for Cancer=20 Research. ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://cancerres.aacrjournals.org/icons/banner/title.gif R0lGODlhwgFQAPf9APPz8xQWF35/gNTU1Pn5+ezs7XV2dyQmJ1xdXi0vMAUHCIyNjR0eHy4wMQsN DtnZ2eLj4wcJCt/f3y8xMvv7+7/AwPLy8n+AgRIUFaKjpDw+PiEiI/X19RscHfT09AYICe7u7kFD Q/z8/Pf39/39/eDg4AoMDQwODx8gIQ0PEA4QEXh5em1ubyIjJB4fIAgKCxwdHvb29hUXGOfo6BAS E/r6+ltcXRMVFiMlJvHx8Xt8ffDw8Ojp6dPT0wkLDNDQ0Pj4+BETFBobHOvr7DAyM+Dh4bO0tDM1 NiUnKMbGxygqK4GCgyAhIhkbG+/v76ipqcnJyqWmpuPk5O3t7WBhYTY4OSYoKRcZGYuMjMPDxA8R EkxNTqqrq+Xm5s7Oztra2mxubhgaGjU3OFZXWOnq6j9BQXR1diwuL5GSkjc5Or6/v5OUlNzc3M/P z1FSUyMkJVJTVHp7fI6Pj0pLTLi5uaanpyosLZaXl9bW1q+wsERFRsrKyn1+fz0/P83NzW5vcKus rEJEREhJSmlra7m6uo2Ojk1OT4WGhomKiq2urrS1tScpKsDBwaeoqLGyst3d3YOEhHx9foaHh6Sl phYYGd7e3ra3t3JzdCstLtHR0UVGR9jY2D5AQFlaW5ycnZ+foOHi4p2dnktMTcHBwsjIydLS0oqL izo8PDEzNLW2tk9QUTs9PaGhojI0NWJjY0BCQpKTk7e4uJCRkTQ2N9fX19vb24CBgmVnZ8fHyNXV 1cLCw5qam6CgoVVWV72+vrq7u0NERTg6O4iJiVhZWoKDg0ZHSFRVVpiYmSkrLG9wcaGio2ZoaOTl 5Y+QkEdISbCxsTk7PHd4eZ6en8TExV9gYJmZmk5PUKOkpczMzGFiYpeXmGhqanBxcldYWWNlZamq qlBRUru8vMXFxnN0dV1eX7Kzs4eIiISFhV5fYJubnObn53l6e7y9vXFyc2ttbcvLy+rq65SVlZWW llNUVVpbXKytrWdpaWJkZHZ3eGpsbGRmZklKSwQGB////wAAAAAAACH5BAEAAP0ALAAAAADCAVAA AAj/APsJHEiwoMGDCBMqXMiwocOHECNKnEixosWLGDNq3Mixo8ePIEOKHEmypMmTKFOqXMmypcuX MGPKnEmzps2bOHPq3Mmzp8+fQIMKHUq0qNGjSJMqXcq0qdOnUKNKnUq1qtWrWLNq3cq1q9evYMOK HUu2rNmzaNOqXcu2rdu3cOPKnUu3rt27ePPq3cu3r1+aP4zEGhzLUhYCfxMrzhlJTJXHj4ft4Fkj VxR5AtBlsyfnWYnFoNv24ke69IEhOEdIWaMKhQofERSUjmBCyxkzpQCELskHg+/fwIHLCEYNURIn u1ciKF06QQGbANihe8G8unV+zhLNSB7SzPXvzIk0/3rO3eTy6s5r+joPvv0gEuU9GmhPfw6e+CTZ Nycf04KOE/TRBwt+Hc0XIHgN/EBgSPqRll5MMwgSYAQ44HDDdROMsOBGBh743Rk8bOhRg/w8+BIu DYBnwhxYZIFHESXU8sMTLCxSWgYiatQhc93U4YknoeyCDw7gJZMjRySa2NIMp3yXQid4xIAQBTlY EogGkx150Y6lFVKQCDnIocJ1DEihZUZJ8scSABJel0A4DxUA35kVcUnaAgjBEoF1DnxC50VpukRB HN8J0sWfJtnJD54IrXIdGIhWFGhL4shwnQaoRUqSooweBMt1qmg60aQrWdDJdRv4IdIj7CizwKvK ZP8xxUYe4NJIIViwokaWFXEAxRNyvJpOBSBEBAAUjqyxQCIVhJgRHhnsksmW13VqkBrXhQBRLXRc IwkvsWxCkQhQfCPLss1OxMEoiiyABiDTODuRFGpM8uoCnzAi70VfPIGGFw+R4EUesmCxwB2EMIMQ qQLlksoaiNzxjAQhqUGddcKAxAwkISDRRAqyKaACDGeooowICtUQggYstyzHQOHcMwEDNMiWQhMN GLOHRCI0MgYRLtRMmglCJABHFA1FQc8ELgSwJwZC2OFGHQvxMEbLLWsjEAUC4KCCCRvA0UOd1SZU wXWGNNTDJdAgccWYKVyBQxoCfOYQHnG04kIQHyj/ALUdgmTAQUMkZKDKBB1Y+gEGMEhtBERDFKKH Ek1oEfIJUQuiDRALqYI1yxcMhMgBNETARDGkLPQLNUcwccMHpL1wBTLFyONBQZOWIMApb1Cypw8B WLGKJyhzJMIl1zXwhUc8tBMG7O050EcbCRFw3SD9+KEJDe3dsA2vCwHxRAIAtneCGGoSVEMUi5T/ 3QmvqIoQKDBYd0k/I2wjG3Mw0EERpwm5xnXMsJBNGCMA7VFAB9BAgYVQQBJXMB8qHKEQAmjjAO67 jhY0Ia6FOMEWMLgYeHzQCl0o5ELVMYZADLAn5mAAEAepgS/KwL32+GADpSBIkixgAQNQYn/XMUEa /6DAkSFQ4joG6MgILGEFD5EmDHlACAEcUB0FJCMRQfAQOGrAkAFowonAQIxBZjAMJ8LgCQiBwAGs o4N+mOM7Y8jBRACIEH1Y5wShSIgIpDEmD93idgjxwDI8pIEGHqQIc3AiCvyHkBroohVO5EcQpJEQ BliHHP2IBxCZUwVADqQL6Nhke5SgsIGQiAhZCIaHNkBEjYziOjJg5EZ+kALrjAwFWbzOARRkkClW 5wVIyKWHXqaQWNTPic84SCVeYZ0UzEIUhhBDDUsThiQcRI3WWQIhREmaFIzif2U7yAwsWR0MjO0g FDjEdawQCEO8gkjViUYj13EdJWzBGRNoYRN4af+QL6DCOjSYhSHmkAYTVOcA8jNIEZrQTCEwAYHX 6YAaEEJO5twiEyi0jiIKkokJRNJa/SCRCyp6oC3IMSPCuM4sMrWRHVCBOVu4wBMYkYRERKIF13HF 4AriS/C4AA6XSIYxUPCdK5gJIZaAqC054QY4WOMIVDzArAoCD05YJw1RyFQB6pGA6hxhOwXBZnU6 QYTv6BSc1gHpQAbBTU4kBAvWkUEczpm9bFiHCwfxA0OZY4J20EIgEAiFKF5QjTQewToh4EKmdsCK DVQnBCctCAfGwRxNrKAOvkiCI4iBieuIAjkGISk/FNDO72zBk/34QROv84E0gMMNbkiDpbSQQx3/ tucDIQDDJbIhBvAoQyOnso4gPiKFM/BDD3nQTUGwAQ3raKGDBOlpM6NBCjFSYA9/YC0kENIDJlwn Amb4hTqAQIAYPIIO6/iEIQny0upwoggGyYQdqrPdsK6xOrW8jgt2htbqqFUEpvDBdQiB1Azygwbf OMggqmOH9PVDFtbZAhcJYgFA7LQgABiDdUSxL4HsYa+luQNCCtAHfgSjDlMlCB7axFcThpZP38FA BQjSBUfltBxFGAEQgFAERkACEco1JXi2YAQyDEQCniCqdcqA2orM4lEgycA5DoWQCrjAOrvoJRWd K2KDUOAW19nHQUbgBl0yIiHrHYgRWliaADwA/yFLqE4rIGBf8BxhDWoAhA5QcAuLKGpAAynAE7bA TX70AiEzCIR16qtQS5VGAXmksIar08aHJMI6SngEQrLLnDOI0SDliEQlEpIJJSx6TgQRLXPsgAg1 GMEWTUDHhAWygutg4AkaOsinhXydMTi4H404YnUi8GuJRNA6tgBJmhFCDevcg3PR3XJ1IIWQIgiz NERI8UC4IODq4IB6EAmBdbZhNiEw5wN4JYhYrUMF/ohACmDtL3NkUKEKuaCP1rEDKBByDeiVZhF/ PUgMJl2aMhRkCqKwzjBmvRALNKk690OILkRIGksgRATFS0itq+MG8AlE1aQZQ7xJUAQjDwQbx/9m ThAeBxES8QMJkTUIHK4DJ4wolTnJTokFpEAIcVenGBbgqbRLw4Rc6HE01VECGyQ7D+t8oBEREUfK S/OLhAzhn8wxQJrXzZw0BJ0jivIQDnARSBtYhxrLJsgCvF0LgniARBFAY0OgYJ0ApCIhNchvaeQZ EQ90YRSqsE4V1PFi60xg3wkhwcaZo4AlSMTlWkvILgzMD1Zk5NqlYTRJmPGOY4BD79VpQLGijdiF vLE6QpgoQXARBuGO/iECEKUCmuz2wzLHGdrmOmk+IHewR/LRcwj4Qdig6owl5FPMuUEUCYIGVEGd ITqwzgGKLRDQ8yMQD+GBHz7RjYxWZwN2S7X/dSJg/IR0wUbVOcPSI0IiB2g6IUkAcWn4kBFTW2cc JOGBIojRB4pj6PUCIV2lgT0KEQXW0QEzRhB3cB2eEBE1oAdxBQUPMIEUOIFfQArzxRwuAF8DoXv8 IANBxiG/xw8mwAIeVxDlYB0KEAmPUIEuGA3WYQoF0QPmNn5LQHgK0VXeVgouWIEDMHT8cAUMMQW/ IAx6YH3W0QLhNxCqFgbQhRCMcB3cMCqYRn39AAo4VR2hgxFNZx3gIBIlQAyvwGbDVh0TAID9IICk 8QcLkQEHmIAC4QHBxRwqkAURMQS9VR00kAAT0AB++IcNQASYYGAn8IQeaHDyMYIOgAULsXZV//QG RwCIfzgBE3BMzDGFBSELhcYPr+Bi6ISEKSAGkgiICSBKlIB4B8EDWKAJ+PZL1aGEhccci7AQIkAo wxZp7GcdDWCFEuBYWpgRyGMdfSAlHkEAxKCD1uEMn7AM/kYaZyh01sECbfiGBMEDZWB4ywMRP3Bf I1gddNUPHoiJBeJZaCAJ5rAEWcgcVrB+uuYO3chuBuEBZvcdDBAPCIEHWvCOLgRuBtEMtrdkx2AG 3VYasFgQquYG4UMOB3hmj2cdSmIQvWgdW3gRbmgdLjANHjEAPsd4fVANpVAshWB4aKiG/CCNClGR zIGABMEG6VgaaUAxEJEESqaPpPGNHhgHH/+hKF4yEM2ggmyIECPQXjTJD9lwEDnwB83IHD7wBxc2 EFDQiu9IA9NSEEVgCP7HD0fwL88xCWTIDwUpftWBSQoBAA/HHEyQOg2JHrzoi8wxkRbxCF1JGozI ET2QInJGB7kmEJIgktBYHSaZEChZGio5EA9Qg5wEkw8hk+N3AzIQAI75mJAZmQEgfODIjaWxAjl5 HTsJWKvFHAxgTWMmlMyhBZQgmab5mNRmECKABd7nl7vWD085fqV5mqbZAkZHECWgAdaBDIBAjAIR Cl35lUxoHTbQcFhnlmSXlszxkAURkb+IETGQSNahBydYEWSgStUxBqBFEHtphiMJhCU5jdX/MZgC UQlIYB1EkI0PsY3WcQakkAsDEJ/yOZ/0+QN5WZnWgZmJmFYFEZLEmXZpCAbW8QJYUAn0eaDz+QNH hRB7gJ3XsQYFQQtQyQ/IYKAIiqA9gAf3yQFfVB16QGUEEQpJKZwfR5wLAQDXWB0w8E3KuR8K4Zxt qRHVwFpUoxFyIHjxRhDJwJek55fimZJw2A8gsAXWgQGg+RAcUJalgQlNKREeqJ/jyJ+4aX/M4QCq ZxAzOmyT0BE5oAOYRxonwI8C0Zr8QAQXwQqY9n4FYQpJuIQlWh3FmTLu+EvXQIVq+aJsWRpuaRES 8AbXcQTwkBEAIFongDSqKZ3M8Yw9yhx//4kQgUka5NkPQLAN15FgEEECRFodJ2ByFPGkmSmlBIEI 2cJwA2EJ1yEJH+EIfmodcFAQzXVQnDoRxsUcEQChB+ENbRqLpRGnieef1SEAdrqcaymRGkECbHod +pARXnCAsToQPdCZpaGoA0GSjXoQj8oPkdoP0pBTvukQfMBNG1URnrqf/mUQA7Cq1fF8BVEL8kca ndCkGuEFM1ka5kQQtqhyyzcREmB9KcCOuPlkr+im/aBqvJoQpHAdr9CsDcEwEJmnpLGnFtEFSvpo UFoRzVcdb4AQxxCX0hqA4FmtBnGt2QoFHWAdQQAwEMEIjsYcbiWulkkaFSuCoDoQJJAP1/+BBF9H Yd1gS0HKEVwgSiaQDgQxDdcxDxWRAQbFHDQAoM9wlSQ6sCa6EOqAjKXhA+nWcg45rM+pEY7wpfzw AVSwnRNxesyRsQZRAMXwf33JqD8qmD07AmVkHd7QrQxBArr5SzjSqS/LDzGrI+FUEF5wZdZBTAXB C9w0BjnLEQTgUdXRDgSRAwBLhzA0EdXgfzRwEBwQtwGrq6RRsAnBB9ehCTm6sFmLp8TKEer0HZhA CGKLEJVAmQLRk9URBm9WELLLo9P6sW0LqT3bD4pAefygAwCaED9rHTDATwlBt4C1t32bEXRkELhq HUJQSgQhBTZWHajqQACKcQkxsfyQRAT/YYC6KKZAaRCskLSlYQL8RRCT8B1PS7BqI7jVQQXVmRAM 25wOyw8QexEkwGnfoQpR0AZo6AFfYASRwABK0LpnU0V9xr7Ayw+o8J3RuLvY2rv90GzXMQ6ISRAA MAqkSgKKZh2LQGAIQQa8sAxPuLz5+anlehCbsLKl8QE/WRCfcJX6O7oEIQ7cwAsHQQjjsKAEMQWt x1eGGmglJnjskBCg4Am30Ky0ZB29kGapAMPMgQMcCJbM4bkJkVLXYQMDgE6ygjulmxAwqqceQQKX kJTVwQRbsAzEcAiH8Ae9wLikUaMDMQRfagI6UAQW8A4C8MAvlz7USsHZKhC1cJ7XUQUL/0AIbdAG fmAJaGAMJ3ClA5EJQ1wdJjAIdMADAGABMVAE5bAEHUq4Hci8LMwcajUQlBpX2GAQMaCQ1wEMu/AF FgAAAOAESXAMy4ABJXKfkipufcAL4DMCC6aiOJwFU1caNAAGjDADHmABHsAGeXAINralBDECLVka YPAFHJAJpkCm1OSvb5rFDgEPEHiztuAIXtAGXhAOu0AFKnAMYnynZJy/+4sRIuAJ4OxEaYBqAmEP 33EEIYCuOBAC6Bs7HTbIJ0mNB5EFlhhXSIAEB5BRYODPAmEEhlkdAQANIRACenAE08QPTNB26mbK 5IrKCYEHaswPrnAQXWANCNLRIcAJ8/+qAOdAECSwBsxRBnFQD0ZwCM5wHbKAEIkgbNIbDIEQAoEw Aa24ASwlEPcaesDQmR1QDEj4xQYZtQ1RC2X1HVpwABKdctYQc/dLEGX8sCGBDTP3jhFwdwTxACAn Zw+wAGqcnLk7wQs9nhYsEFmQ0QGCAr580e3qIfiwa+MapS18ECKguXTo1gUxBIbQjUygnlJwc6SB AVSszcPbD/Vg2R5CfwQxA9D6HUiADedrHRSU1XAKEWzQ1R7iAOoZUmOMEGetvyLBAXXQAOBJH6aj rgPhCAddHT7QCUYmqtYhDzw1kNq8EMpgHU2w1+UJB7vNWlV3ELigAXEJHirgChsMjuj/uncf4R3W MZcIAQUrbQ2tKxA5YAYTOkJHkAifRgF3cMntYQJmQHsFkQWtsNLfcQMs0N39oAv7zA8vMAefwQrc tAQWXbLVQQ8RMQX5gITgIbQDMY/MgQm8OK+kAawkkQrW0AIhfR0+AAOzgAZoOBB5sLc+QARF7AvJ zA+tGl3BHZ55zRxCAN0DkQqrQN8AlQCIUL/9wAGygAxeWxo3YAW3cJthBU/M0bwY8byYa1eloQVN cACrALsEkQT78NDWYQIooAfWbBCgQAUboNyjSQT56kHnoAQhXh03gAnuIM4EMQqYIHvIEHnZ892k EQJNyuX84OASsQeGAAP8zQ8ncABm/wCisp1+vOhdv3oSM8AF6+AGZVAFZ8AALmAFYgAMvQALSm51 OlAGDeACtIMG0CYQIrAGcSAArM7qtuDPIgAJrd7q4ZoQbbACs64DpjBqDZEEFyAKYrAIDIACKIAK gTAIV7sQMZAH3hACDbABKOACBwANgpAMinDqBrEDsqADsx4J1d0RdMDtrc4HAiAOCzENE9AHxqAD UQAFIZgQPSAAcyAGVuAC0X4Er9ANdwDgBgEBa4AAfYAKTAADRAAMVIBrxsIFVKABE0DsCCwGW2AG RmDRB+EBhxACRIACiwAMkhBz2orrs74OTYoFkTDrfDC5EzEAphBbmDDsLpAAnOAK0v/g8f0ACAaQ 6/EArwQBAnIg7qweCb6AEgRgAQWwB7HACwJwAbBgBD0wBcqLEBawB9dwAenwAMobA7Vsy7ZM81rf 9diOTllvy9CccQwBAFJgBHfAB0tADFzwAzvwmikDAl4wCYdgCxfQDL7wCDmw2QLBAWFvy3CfEUDQ 9VpPqmNUB0nAAxYQ+AkBABJgBGtwAUtwAc/wDk7vEDFQANMACOegA9/wkYy/EATgBFlQB0uwBHxw DIrQBXvvEB7gBU+wBHdQCrQ3An8PACfoAYQPAIENERwwBHTwCQIw+RlACk7w9QJh+4Sv8zit+4Qf +qIS/dI//dRf/dZ//dif/dq//dxe3/3e//3gH/7iP/7kX/7mf/7on/7qv/7s3/7u//7wH//yP//0 X//2f//4n//6v//8DxD9BA4kWNDgQYQJFS5k2NDhQ4gRJU6kWNHiRYwZNW7k2NHjR5AhRY4kWXJj QAA7 ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://cancerres.aacrjournals.org/adsystem/graphics/1217262986135/canres/Landon_256x80.gif?ad=18195&adview=true R0lGODlhAAFQAPf/AAAAAP///4ZMTYRLTHdERXhDRIRKS4JJSoBISXZCQ3RBQnJAQXA/QGY5OmI3 OIVLTH5HSHxGR3pFRm4+P2w9Pmo8PYJKS4BJSn9ISX1HSHtGR3lFRnhERXZDRHRCQ3JBQm8/QG0+ P2s9Pmg7PGY6O2Q5OoVMTYNLTIFKS3VDRHNCQ3BAQWc7PH9JSn1ISXtHSHZERXFBQm9AQW0/QGU6 O3lGR2s+P2k9PnxLTHlJSnpKS3pMTXhLTH1PUIVZWmA2N1QvMFIuL1AtLkkpKkIlJkAkJV41Nlw0 NVcxMlMvME4sLUwrLEcoKUUnKD4jJDcfIGE3OF82N101NlozNFgyM1EuL08tLkoqK0ElJjohIjMd HmI4OVs0NVkzNFQwMU0sLUsrLGM5OmE4OVcyM1UxMkImJ183OF02N1MwMWU7PFs1NmxERW5GR25G R3FISVw7PGNAQVA0NV8+P1Q3OEsyM39XWHFPUGxMTZNpao1mZ4lkZVxDRHtcXZ53eJVxcnBWV45u b4tsbZ9/gHtjZKuNjqSJip2FhpiCg7+nqLqkpVwzNWlCRHRfYIZxcpN/gKWRkraio6COj8m0tcCv sL2trrusrZOHiLmrrLeqq9nMzcK3uODX2N3V1tnT1Ork5ejj5Ofi4/by8+Xh4vTx8npFRUwrK2g7 O2Q5OV01NVozM1gyMlYxMU8tLUgpKUElJWk8PEQnJz8kJD0jI1o0NEkqKkUoKGc8PE8uLkEmJkss LHVKSnBHR2ZCQlc5OYpeXnpUVHVSUmVISGdKSmBGRllBQYRhYVU/P088PJh0dJJxcWlSUnNaWoVp aYBmZpd7e5B3d4t0dLWamn9tba+Xl6yVlaiTk459faOQkJ2NjYd5eYV3d8WysrCfn5qLi6ucnJaJ idLBwaaZmc+/v8u9vaKXl7Wpqca6urKnp9fLy9XKyq6lpdPJyb+2tuPZ2dDHx+HY2N7X193W1tzV 1czFxdrU1NnT0+zm5unk5Ojj49fS0vXy8vTx8eXi4uTh4fPx8f///yH5BAEAAP8ALAAAAAAAAVAA AAj/AHFw4LCh4AYJGhJqiJChYQYIGCJGvEDxwAEUFjIaMHDixICPAx6INEFSgMmTKE2SNCHyAcgT Gw1kRGGRosSIDjNEUKhBgsGBBIJ2GJqiaAoPSJGqWMq06VIQFbaUqLDAg9GhHYISGGjwoEKGDiFK pHjBYkYLMT1+bLkyZcqVLEWC/AhT5kyLB2zehJBzJ0+fPzlohYHVaNGkHnIIJGgQ4decGW5iIGsR o0aOateOLOn2LcmWL2Oerak3It+GfhMC3gA0KOEOhhErdbp0RYUwW3LrJgFCRdGhMLRyLeg4YU6x ERFUvHiZ41y2nDsLWNnSZeiNo0lfkAyZZ8+urQm8/4YdO6ni4cS9Q5ZM2WzzzCE3m5COkrrc69nz bpd4GrXC1awJJhRRh8nmVAwVlKDbgrqVUAILIHgwlHCMefWYQ+yVxdxl8EE3H31wgXadXRbgRRZ3 ff0FnoADkmcUYudVaKFC62WI11loOQeShx+C+Nl9dGGXkYn7SZSiaquFV9iLiDEVAgsMRpmbg1RW sAKFjfEEVkM2updjh/LRN5191gUppAU06VckTkeqtqJW4hFYXmI4bNXVjAsd1+WGXz7noZgq/ThX XWelWRqb/v0XGAGwJaWCVUchFsMIYkBhqaViSJkbbgxCmAJ6ElToWEPITabhAWdtBOYDbfn4Y5kD dP90pqGHYtCfTt4BGN54hkVK51YyFpdnThlqaNmXq7YqJpkj3qUfAje1+V1BHBTggQoxMADCCit8 8GhSINAARRRSSHFEuVFEAUWmDELxw7hRGJGuGGGUEIIC1DJ61KNZIVRqe6mquqN8PXbG7KBnlkia ZBh0p+Kiri3J5K/o4bkllze1d2xafrIanasimpndifzl9PAGMCTgwzYBBOBJISKE0O0CIZTgrh3c tBzAOs9wIYW6UOjmbhSGwKNzNbxIEXQYNIywQgI9sNyyOD6oUABCNyln7HsdK2vwq7DWRSKRazYs ra4s8jqnYsB2JawGNY61HKpcD+xxwdIdLPKQC5f/7FBqEvhEQAp56PMONZC0DAkLFdDggKVRPBNA PI9cc00lAZhDBRfpruvuIusEwM0jpH+yDzNSmCGVg228E0Ai00wTgD51fNDBBpHJfSOHXX/sVohA xiqasyQbefabWklcIMXBendxqabitbGOmt2N99chCz9238YnqhoHHXyQCTphRGGHzs0gwfkPRkge gDBKfKGEFcv4oznnlv5wRDwBXCKEFVYQQhUwx4fU5UYM1AgAH6hwhCgEIgCTEMECOqCBjJ0qYMny nWdeNShCEa9Wt0rNtH4Cp9f0KlJsa1uWLkSqYlUGgxm83u84aCa70ApF3usJATyQhwAUIwpTuIPO /7whBCQc4Qi82EfLhkELMCxhfn8IQDM2ly4pPKJlmLgCGOQnQHOsowtSeJcZ4MGNJFRBCaxwRwBG EQYRfIADuTOVhgJGvT+5Ki6w0l6hiCSZEOYKeXGSU4FSWDFhXSyOE1nO9DrSOxluMGRiG9mh+iNC CRBAAX4IwBZQkYRh6GweV0hCF7pwCJ3tgQlXUIIAq3AJc5ChC0ecwidaVo4mpLIKSUiCMBToMyNI YR+HSIIQvtAInfGCNwWIo9ZemCPqxeduywIbws5ENhw25I8QC6SLBlknFaaHJ3FL5AXrVj2v5Y2G e1OYfvbSJgl0IAY8UKAQruDJlrGDCVYgAxIw1/8yYjQBDLhEQxKg4Y8kjGEKXRBiy85BhCsIwQtk 8EISOPGIzR1hCvHgRhWskAtQtMwfYJiCCFKASEVisJHRRKf2tqcma+JKUdlklCBR2M1CqodYe8KR wOwGF0DpTY98W2e0/vafAqygBOtwhxXoqTNpNEEJXgCCGvsJiyUYFAleaEYAqoCEMSBBqwt1xRWC MIYujMEL7rgGErqA0Efs4w1fwIbOzsGEKhxBBBXUnZd2Wk4N1uenkfxg2SBTSUAG8oS/CoqMLKYn C0rvpHaDpk8FhZ8PWjM1G5jAFqRgh33IYwn1ZIcsaqEEICQBEzozxlPVN4UxELQKXsDqLhdahCv/ eMFnXEBCPK5BBiogtAvuwEck/PFROjAhCFzYQgU8IJa5wZCnfj0J8MLmQTTxkZ1EPVmABqO8o6TQ m4zFqdy2xqEYAmpMeGyWdZ81VP9IYAE3IMEWosCFOxziC4MIwDycgAVaVIEMSYhEaptgBQZygQqV MAdssWoF4gbgHLUlw8+OIMRl9JatXfCCgHX2jVgMAQhSKMEIYpYACACMnDxKafaAGtRamc0h2KRW 2rqbWPAaMpxy3F0zzTvZ9FZWYcWzVU48UIFXjIAEYYCCFMaQhD/4Yx5YwAITvuCFMZChFw5WrRJY ywcpLtgLQpBrANRR29tKgQvmcEcSXsmFi3oh/78t60cWXLEEJPyABCMWAQVCwAGT7hilIMteYNUZ 5BfnEG3cnWmNbQpO8YpTxxyDbnSlq9LqXtc0DYEBBYpsZBbINwpdqJ87YFEGW1bhoGMQQjEDYIyq GpQP9qsCV72aBDB04sGuGAJZu0CJACwjCeorFxfI4NGWZWO0VUguCSogAj1TgAIg2ACknWnHc1Z6 eOstNGG1Gx6ZbtO73bSx8xqrVz7x9Zk9naygqcm9iHAAKhXg9AiOHAYz8EGJ2OhGN7ARDC9MQQpT AMIVrKFfbETicpmTtUERSgYrzOHW+77GI0zXjFxSMQpHKGXL5vEEV4BhFVFowAiY7ew9h4ABEf+g W58knVIf06W6tCqbH2FKwkSf8LviZuFDXGhuzABaxUAK7A0jogHbxDver0j6CFhgs5zprGXpa6AU qCAEWigjHDpzBzRk/V9YHqELSVgCE7pBD51dQw65vO0ZLNVZnS3DCXU9whaWHe9mPzsEeJ+AAjKA 4jDdccUwvzSms0vz7UZspjnQAZwYnZBD8nyRPAZ6mQatnQwooNlHR7rSRyCuI3hBCbRgAi2+kAQq /Iy+qxACGIagxScGELYXn3oSlHAF1j9RgEnwAhXU4DkpIEEJTMBCEWrBCiREAc9Ht/vdQzCBCYAg AReIdF8dGSg8hg3b1WzvNbk9Y8TrIDiKbV7/ozFkwXH+meU9XjdLt/NsCogg85qfNw02O4YqfOEK S4BtF4wAudwGQQhKEIBWgEu6hz/jcgRU4AVVwAoBiHu9xTlbEAZiEAVUEHa0kEqrgAoOYAqZp3wm 13zOBwLRR21+Z20ut1L5oW3HE1PdlXjgl3M04miJpGMrN33UV33ql4IXsADPhnmZt3lIBgW5JVFo gAQMpC5b4C4IiFWmhQb6dHGeQy5TkIASBVFl1UBQEAa4AQVHcFa5RwUa2AAcmHwll3fNFyE1iG6T hl4nOGgx51KFFVMmZBg68H2Ldyc3FhaPB1nVI1lAN017pB8S0IPv94NKRwIKYgYXNUpthoSc/8I+ F0UFktgFPgM0QpMui0gFbFWJQUMDNIAbP3AGR8AFqKAuNMA48FeGzHeGfKcqmVFtX1NpgdduQkZ4 bpJNalMUdZgVWCIgjIEQjscwGdMCEoEAlhETrigraKEW0bESH2FDF4AA0oMCFEGMEDAB85aNI1cB 2WgLJEADJZBk6TKOQbM6Scg+5tJmp7cuulEpQ+NLR9Q5l7IgDuCOlhIGp0ADIjdvdedseLeKHsBe LUA3IEESsQITqeIRd4OQaKIRHVEiF0CMN9ECEskmbqIBM4Joh7dNu/iC1QIDKaAAMeAtHkAAB1Ej fCFCfuETA8EBcDMRfAQBO8EQGIAqITEfK/8hEwfQMDuBEFwSjRjgAhi5AKfQIA1AAiTQAEqJlEjp iQoSgbhRL49oBL4kL0DDLkkIL1JglT/QlfkTL+gCNEHjjl35LltwCkc5cqrYfBLQMKFCEC85ghyB ArbiFwwBAQiAFjMhkxFAk6hClzIJGBzgk6bBFxgJGwlgFQlgJwchGIgJG1mRiynQkcLRASqQCU8X AraDO8SSARrAAb4QDe1gDwnQAcjwdAHQDtHQAyZJCAHQBwwhCagZDXggARBwAAYwACtxAgcAAYUA DjpjD9FQAC4JY6g5CtXAB+8CDAFADadQAkfJAtLZlE75lFBgBIaQM4ZwBPJSjlmJcdkZANv/aQTv AjnVEDotsw7V8DOWMgmouUbVEDQiVwHtl3cLkAHRgJrigAwcEAHSmBeyiZqhEA22iQHEiJk60wES EBkZgAf5qTOJgAwSgjs7sQGCAJwtI5w7oAApEBQFkAIqQAiZEAMKYBUtQoc60AEvWAAJEAMI2jIl QAEfQABwgxoRsAG+IA464wkUMAGZ9J4BEA0r4JrIkAApIDWoiQgFUEEWQBcX4AsIKg7UQA36EACh IAi34xMdAKSZwwvnUw3qcgokIJ2e9o1OmYREo0QtcwhI8G/lOC5SYAhqGgBsOgXyYgR8cA8tww3X 4HT3UEBS0GstIw+Wwz/rYAQOMJ/LNwGD//mgs5kAC6AAsakzmxA77RAAmUAACCEBLxoAFKACg4mh 7TANm6Az6LADJVkAUDo1sVOlASAIH4AUCoAMl+oJetAtKRCZgkSZQqEAIYAOTzcLDRACCbCgOhEq goCa9/ADpwAIT3cIq1ANowBBhRAAyfBsSBoASGAInoCpxYoBGfGk9hAA4uAAXoUEWwAI3UoIVuEB DPB05VALjiAPASAPyxAAj7B/UPAg02mm8wcFoIOajlBEBhgFvICeOjOwqzAFR9BlAeAN8SM/VXAI leBbXcBPARCvqXQN+Iqoy7Z8CxABBeCoAXAHzNCtgnCUVoKklDAFUbAFshMNVnGZTwcFbv+ECAGw DbpAAoswp80ZAgvgA+O6CecYNIAwDrowASuwA5ipD4WAZ0ArIdpkFLvIi4OzABWQDk9XBVFQAQoA Rzrkmvqgpy2DD2RwBMzwdI6gBGTAC0bTrYGglO6pM2AQBF2gtYngAQWqAZeKr0GQe+rTALvgOnqw AFABr04AC0OAWh4VCUDAOWLar54ogYvAP/SqM9YQSi47LrxguU9nDf61CnegptgwBE30BVYAuEhA BpcwV65QC2CgBO6wD/snYvS5ZwnhAbKjM8NgBXcwCvdgBFIBBXPbP6L0suigD873q0+nCvbyAcgA AqYABVekM/hwBFPhOjszBaQYBQ4QBnj/pmfAGgCUwAVGEAYVwAAqoKtyUrXglwIrMAIIGwBgMAsj EANgywHJ6gl2MFUBwA9UlraYG0pd0LktwwxR8AOC2jLEhwRG0K11kAAF4ZotEwlKwFWUSAMk8Av6 gA7v1wBPdw6xQARMMATl0DLYUERSMHdkipSJyD+RwAhPlw1NIASmRy4wLMM6kw1VFQSt2zLdoLhL IARrZoQJ+MNj5gSwywocewdcAAUfSwEegAES8AEJZEqhdEV8kMBSgLHlUGBRcAoJVAciwAJaqzNc ayUfAAIksAY+6wggVq0t4w5esH9zt40ioAdPtwxUAAUjwABS621Um6IqGhQpwAAkML9M/zAGJHAl n9kD+uAJwEAG/ssPrSAEYNUymXtbaHvADLvAAQALNhwFzjoNIKAACqC9AYANV1AFVMB/ymUKCVQM DfADIQwLsHAFVzAHxIUNX7AKcjem/Zpk1RAAkcAEOmxsRLBlbXZFx5zMAZANRUALvfB03YAFQ2AF QLBWXMAFGYZaLaMOo1UKQsCxy9AFUTAVzxYR73XF/RRKWnUI5zIFXqwEXQAFDSA7xWAKYTC/S3AE VOEBk+LO+lXDVMA/c2zDUEwBMwACE0ABxfB0aiYFEBLIcziZhPy+INAA8wsLSNAAK9ABHOABLOMM VFAFlfxUmRwA1rAEfXydocMMqUDPT//XBElwBInawSIwAW5gzUNw01vwic0W0dTAhSHMBE8UP3KF DUsABEeAz54Ijkl4PvJwBWUAzdpQBEuge0IkD7SAC/eqM9qgxKvWMt9QW6XHBWcQBWfABV4AzmM2 Wl+A0v4QBK+szgqwHRvAAARNDGAwUAHwDFMwBaqAxOdwBVPgACSQvEoJBfN7BVxQAR9QACqgC9Oq M4xQw3Ag0S7tACKwAgqALSFAAmTbMoPQBTQwARa9JFXLiymw0R390RGSAPGUDlOQBF8wDzrDD7Dw BSttDUJgBGNaAsXMDIONsQHQCqqg2K+ADp5AAj+gUEA8BF4QBSzwfiTAALrQnBQYwlf/wGRAEARR 5MtAMAv8hynuwgU5MwhNUARh3TLaEAtj5QXrDQux8N4BoA2yAAsEpzOWUARgcLZv6tZwLc618AUc ew1BoApGIGIUkAF6zddPtwcB6A0BIAdUkAqrYNi4IARQkEDU0NiPfVcewAEJsLsb5wS0EATSrV+0 gK5udBhsLMBz7AViQAEKwItq09rB8doc/XQebS8+EA06ag6VEwn8sNu9/dtJ4NkhIALVygwXhdyQ TQIx49xUgAT43Q1DgARQUAEgEAIjEALxBAlSoAohvATlkgpIsEsWDARd8HRScAaG8Aj+4A/59g3q 8HRjfQWHcA13nud7LtZZQAT93TL//11nL1sC82dFlxsA+fANZBcA7kDEd+21GAAtHCDhWBxFriSJ j/Do+bBv9JoOGixfIy4CCcABkPx0jFALVsAMTtcy/IANj0AN0xANKUAYWCsF/kunUuA0JTm1GI0V PQ7bQE4GYRACP8ql/7vknwsEpzABMQAC1RoIRnAEyA0GqDACzucJ67C6b/B039AKXg7mIHADDdBD 1OB7IfwF6XxmQhQJVQAEaK4zozS/QDrWQ/Dr+54FWCANT5foxicVje7svpy6U3BnFbABEeECBDAB fW0N/oAPd7BWqeDskdAFJUACpoBUT3cFqCACEkKyUFZnxezs9vABuaoAFAAFKw0KSP+w7LZzohid q4Xs4x2t7Hs2Ap5gDsL0BWBQydCOuUDQAOr7Adf+A6iw7ajwChMQ0Y+wulVQdmZt7l8OAul+Cvrs 7nMF7yKgZOej4ECwCkhw9hBFBkBQSsqAC0UgC/it36jkCAGgDEXgBFkQ9wAfBwOv1QXP6GLABUBw wuH8B+cQAP7wB6U1BVDAAhRgJB0wDWf8dPQgDAU4BatQ4Mtw+ImPBCXwCokc8nf1Aa2O2UwAYlz4 6PPgCl9ABQ4A5uubAGzcBXAN7E7ToYd188AxOCAA8joDC17QRiJAAgFQCVUgBKywBETv29HeAAsA oq4ZCNcJymBwBKcgBeNQsmefBHT/P91I8PphPgLAMAro8ANT9+5RUMZGMPZJsM2qgPYRFQQCtgdu 7wRxLwtNMARytQdOABCxZC0LUDCAtixEYJ0zaKnIEiRRtpQIA4VLknIG1Wl5wsgfqDdejjgwpQDD yQwpDBokJ62WFSRHohhBgknjE1keQcnpQoPEupVXjoyYkGjlPCxfpmw5FeWQwXkPkfxgMeFDigQf RPwQthJblwYgPBAgAKPD2RQ6dKQ42wFGChAlgBosA2RLBREkAlAis8pLEHcG+cH60mylNSANFiTw QCgAIChGKK0cEsTLowDVqHSZgqQKvYLfhnihKqJCG3gB+ECJMmXluS9RRID4YSfA/zUgq7rMmjWl S5cxXiIFGFarVhlGK7XJakILW4A9ZcpgSW5wOaxae/wVdAiGzBEoUMREuZix4MYssaQFuOSFiwMS Gk5CiJCiQrWVx2QxqTIFyhYoprjkpiJqaSSASqiYIoq5CrpiChLqWCmAZZoIwohiSNhCFXkKmqcM JbrYgqgPPOjAAxBooMKmgrAhY4sQVCDLLLTUYuust+JqMAAsqoiChVdIGMWcLrjoLLCCBivssMQW U8ExyCRbKZY5zAlgnd+OMOIIJILhJwB2hkjiiC1oAMSTAAxBwgEopHgtthBiOMU23FSZBRUjjJBC iinIuCaAP2i5gonqClquiSuGU/+GCSZqKfQgWWoZgtCCyCniiiSo4MIQSqToAqObnIClFZvkmOKH CjKYTwIP7suvCDAi8imMIwY8TxZYrlBiQDi6QAJJB6doYJujZGnFC0gC2KYBI4QBJYBO+OsCChKS EWcHDxJYoQIj/iionjleDOEDsghoK6212sqRhh27uaaaYkYgAR54pPiBvAb5eckwgxzxgoTFUoBy ix8mg6ogbpDoArwttpCCjGCQvOSRakYJYJRnkJiKBihWKkcIKMYVgU4vFv4BCgfY9BSaABr54gsw Hs0mFiaWOLCRK8C4QuYihlhiCSaU+TIAbCLhpqB7+BgjCRYDUAdXWr5gGZpTV1D/9aT6RMDPIGOa qIKLEiqogIQoKjHoHCyuEAKIZwJ4hgoygA1giSMa2GUcg9jpRpOC0NFlhC26eAPJSqqhRp+CBPlA gRh0maSgcuJYgooSJpBxxhrXuvGtFVjY0aBCWGAh2UBKaMCBfDFlZiVHqBhBgQI6gFJDgw3C5o8k YvqhBNFLeNiKRqxEWrMxkJjiCBFoWAmTJLYAQYUPgAngESS4iMKBBkggoYQ24QjAnSqSEGKQlbIh Qtc3vrfCCiXINyibMpaoIgglWimjm3kMcucRMopn+uy0CSEJd5iefxIggZNgIAIECAE1VkKMK0yF BSEIQQUcULtzDKEKxrNNNXwl/zcfkWAEDmDGcAzCjUCwQGyA4xI0zFYQT1BDFxRYwQcW8I69CGMJ X/BCFEbAgASUi0YdsNGNOpCCbUUhCUOARRlaEQQyAYkFDVDh2KCABCXsMAhF8szLkmAECiSAAxxA kWlY4IAkNAELTsDCEKzghQWVYAQiqKDvxoCGJCTBCxrT2BimYARUiWALXsiiEFIBMA94oAFcUJAR oHAKU4xgBCwIgxk6gwYyIMELQrgCFmQhiyIwQQlByCMp8WiFIRQhC+lhghAyuckrtIIJtADDF6wQ Po15wQr2K0IZNKgbX2mKBClAIEo2sAASTIEVRcACE6BYgtmAQASLrAItZnkLKv84kjVSOEIXvLCE 44BBFacQAQVGYARCLkEJQOACFFhAgQmAgAIsgMIRjufIiZBgNjFYgR8AEQUqrAIJUqBBCBbQASG2 pYjn+kAISjCFJCjBlkgwghxNg5cQTCAvAEWCKhj2Ay6oQhVSIMEKOCABCRDAAysAQQh+ENErCOqN p2pABUIAAhBMoAI0MAMXuqCKjm5mClKQSANesYAKcHQWW6CAiTqwgi3ZywE0kOQkuXeGKVBhM8FB ZRNgwYQvJEGgmswkGZLwBSZIB6xeoII9kRAEVuzwC0q45R67QAU0KOEKQ1Bb9VCBiiNoCQQFKCYG ICCBFITgFEm4gvy64IARhID/pRQgwQ/eeosqjCEKJaABDbgXmU9ZYa5UEMECFACCEYBUqyMhAQ0V kAAFrGCep0jZFsLQgBHQ0IYgqEBFokCtOKWgAAk9y0LRslIRlIA8XABPA+iIUxDUUAEL0CkNtpA9 CoRABKZoQE1B0IEIZCADGtgAARIwgsikAgmZ7IIRymTT6C6ApSKgJGvyZITflmkEFRiBBz4wNipS QAEn3UABToGy6wKpqjSoSFT35KsgrK8KZFDQFCx84eAI4WVv7AJRt+QrL3ghj16g8FB9ioQRj8Fe KIPCD07RAQ7IJ4ER2IAHQtAZTVFLBDNYwQoqWNkjcEEK1MKLGT3bJp8OlQQF/yBFARpaARaIUARW SQEBNlDelWpXbGIzqAoSGQPtSrICILgKjMtlruJqbnMp+IBsJ0kCFVJABjFQQZ3ZEjsPLACnDDCt B1SwAECTS8YoqUEIJNkAAIVHv1MGwQI+8GiWhuAGLKBBA04RhhKI8AblpCEHpstnDxA2AhrQAAO6 SwIqvqKqJGBweFxtBJ+OYQxF0tJ998TNKRQPCX4kanh+sCXf3JUzQjaDGc4QZObml7OnOAUIThoB CCRQvBuYQIsdsAUSVACePW4pgMNAAxbQcQIT0K5pRsBg21J1AhrIQEr9C+jXEkACLxDveFW62xU4 OgEILYB/VyADBsTARBzYAP8HzkyjIm7uiCrgJwhk0OMYKKDKZCH4BiTAgeF2oAAEJ2/BY6yqCxzg ACjIQEtDQAFz7/cG8Izvo10u35ZeVGx0zOi4QxCBi3M8vBCYtghHYIpXBF2SUfZswxrW4png9wdL b/G9ovD0KHDzCET9rRi2wKZfS0FP+M3vFsTgaqtnGs5TJIAGdp5AlFTAFCLEC8sfjtMJUKDIN40u S+F+chHk3QbbdsEFMJCBUaOU3RhoAQIQgJKLx47fBC5vBxKQAuESoOJjJG7C1WUutkC+LRVHqQRI HYFR11u8J3FBAkOOAgukXs/QhTtOH+5ol8ce0v/OaTxdz/oC+B0DpUe7YXn/K7agq3qSouts8cNg dKNfG/li+LqrwY78o/8H+d/2LKY5C25JBn3d9Y422jfAaQqO2/U9trvrHx57QMu3xzJgPwP4/IET pB4FF0BAyC+AAhSI/AItQMl42W12/7syAay4K6M8zCEiNbs8iiNAiyM1BxS9qzG9Cwg5kUs9CzAA DHwB8ss3QIsBD5Q9EPwAD4yB9NtA1lsACxC5A5hAtIMAAtiyChC64RMd7Sm+ErhBHDw+6NtBHkQ+ HPzB4tMe0WGB7HuFFAiveuu9hho324OuhyO/9BvBEHS5ESTBBciAAcjCATgBDDQAC1TBCdQ9aRO9 UXNACRBAjzuzNIM8I4KB/3IZIzT0PAdkN9HrPQyYQBW0wAs0gBPYACjsQCmcwkcbwRIkPxlgPQ0A QzFECZmTwRmswc76QRzsQUrcQUm8wSAcOyIUMwBMQmkLP/FjvSfssSj8QEGswgXggAfQwi3kQi+U P/1jQbSDwDIktTMcQINLqITbnDNjwAZ0QCQUr+6TQApEvdTDwBMYACTiQECMAUGkQg8EtA08ROjy gPxbwUX8u/8CPhkcQkj0rEusRHFsmEu8Pp/QxKpagE4UxgRSAFBsQif8wwUIxCmswgR4gFXUwhNw RQu8RmzsPZ6rt1q0RTQ0wLJAQDY0ol5kQDn8PAjsvTAUOWPcw300gNhiRv96PMVolMb1Yz0QcIFY PDxp24AtC76ho0FWs0FJHMdxvMTi84kh3MQYo0N2NCwKAkWPdDh5rMJn9EAVMAB8zMcs5McvjEU7 hMA51IBbLMBcPMhdVEDJY8g5DMbRQ7uIrMBjRMYBuAB+KkVnfEYR3Ej14zbW64BYXESek7sY7EZv TElw/EGWFMdyzMQh3C9grEMMKAAKyK6ag0ed3ElTrMcYQIGgFMot7MKixMZspMU5XMo0xJynxJE3 lMo5fEirxEOs3EM+zMIMwMiMDEFC5MiOZD0EMMoE4jmk4saqakuVXMm47MG57CwhFJ0RAIG79MS4 40sm9MhR9MyvrEcXMAH/EwhKVnTFV7SAawzD3mNMMyzIpjSXXeTFBYzDpKTKYTwJzBw5C9TKLDym ZvxNjbTCafTIAjBNaXtB1TzJKHPLcnxN2HRJ2URHD7hNYdyAvdTNUGS9DfTKZ9wA4RxOfCxOokTO swRIMmxMNCy4g4vOtlhI6qTPDLjOO8TMiUTGZMzCFOBPsAzNsaRG6GIA8+y/izLJR2TPcHTPHbQ+ IIzPumxI61wB8MNJ3gRM8JS9DhCA/yTO4sTAflREAxXIpHRMg4QBHciBhGzDyXxQh8RLYpTI7eTO AbDIZgTLsLTCDs3JRFTO08wABuBG4WPN1pxEFLVESXzJ2QyBhlzHCMi7//uUUVHcz3n8zEdTgQfA UeEszB3l0dRTxMUUvSB1TiEq0iOFSjgUwDSlyaps0szswgvNwgOwITkFQQ41QY9MgBDluQ4oyS8F 07fMwTGFvtg8R9H5gDQNxgRg0718xxml0RC0AAGw0zsNUH1EzD0t0Fk80ObExTPDASNNSEKlTAhF O1JrgRagPwTAP9SD0gF4gAyI08C0IdiLPbEcT48sTVmUtgjQ1NVESeODPjaprU8N1dk8KRetN5Tj NPz0y97U0NjDgFeFVQA1zIo0gJMgUMVcTlwlSF0tF149UoVDKMlL0FIVve6DAHKTDxcYvQlEAWXF RwlwVvWDLlKERvE0RP/WIzcO2L2EjdD++z0SZU2K8DWoG9mTEQ/3FFc4CwGLK9cMIMm2S9W+zMlR LMUNzDcOGMr420ctFMp9FLmSA4E7NLzT7D7AA70y7Dym3FcC4FUPOFLG8LJEks4xmsqH5NJUjQBE sAdfiADCOwALZUV8TAB+OsQJqANPSISMii6KLUTagzuUm4BbPClSq7cE8FL1rMEwAAZPSBo+uId7 sAM7uAduUDrpe024tC3bui0WiIErS1Px2kZUvcn8hLsZYD33+7cZkNwFELnDg4Bou4ALzMJV5EIL aIE1FZsJAFKlBD1bHKPJwzysQCiCM0imTUgPUIA8sIdoiK6Iy4N28AH/tuC4JU1CedrLcrKHABAE UgA5igTbB0CBGAABPfAbQQgAT7CpCaihQZxW8nNbQXiHTbAHe2gHScADGJMA1rXbGYyyBhADM7CY OyCgfZCDtrmHP+o6w71BAAkETwAGk6UBK/tFh7woVE1X6Dq5OhCHOsiueJoAP0CHdzjbCuCACBBf C46GDAg5A1hW0vUBSUAHT0gHQMg2DoiGdiBfjRsjE26HbVAAL/MBcTjhaxE42W3K2mXDP9ODxHmF KcuDAPABOkMoNEzKGNgySSKBXxCE1/q4YtRDHt0ACfEEr3MGYKABvIin9WO/nHQ4cqsAZ7DeBuCB ZLAYJe6ABhSBnzMF/1NYT+1JA0Qjj3sIgGAIhgAAhS+oAmi4A+ORid9yPj9GMKO7Qd8CCm7ggjOg lqhkyBSoKhgssjbFuxFAnF/Yr+zSYUAogXRQln1rh0wQhxgmBARiWA62gAsAB3TYgkAoCP+dhgDw Ax9OBD6LhlbWYbQFgXYIgDrQYXSQrKal3RxoWjb8AOk1iGKQIx2uA8kyrcybuAIoAFNrAJ9ANIKB AgpgABUwY7MLL7TrXA2I4sCaOiigKpu6SQqyAQKmuTD74nugggYogUIIAH3QhecRrglAtUrLwTA4 PotAAnwgjmEIAH7wmSVghdzhjKnbk5F9OqpjOpQ5viiwjQDYB7YaCv8V0LzHO4tTbefrOkef26+Z G5sSQBNgwDa80AVxaIMowA99gKdM0AU2BYEU0IAL2OAHiD8I8ANqII99CIBDgIOd3oVdgGc3cAPE aYM2gOc2+AXrjQLpGQUSCC7J49dfBmY2C4FiGAWg8Ac7iIJi0AdxnoYTzgRBAAEfGF9B8AR44ANq GIW0XgS/tQNdEF9kyITxxQMJ6AFJGN8+4IAeyIQAiId1uAO/XQQoAAQI3oREGGpP8ARASAdP2IRi KLKd+mJ8CIIo+IE1KAhAGAEeSIQThgSUWYNJQOtAiAIzWIRx8AdueJY92AOAhoVhAAWQuINPiAdD uId44APO4IZ4iAf/SoCDKaiGvwWk/4gMbjCHZ4GG3HmHdsiDFchde9gBGIaHxYaHZ6BuYFiDxf6F BoCEdNiEdFgDvLkSPiBpKGsT/EgHqkIH7RGhGEEgC+DgC+At36GCnW6GrsCHP0ITPpCee2CuOOYD BgmAO1gdSoCC2pQRA2Raqo4BESiGe5ADTggAfIADPvCEKAiDx3GGCiCWQpCQ6cGMezAEzIgHJIjj O0AFNNkGPSCWdvgAQiCE6rUHBpiAd5aDICCgT6CCVE4HKOjxKEATSuCDx4EH3pGkLWgbfFACigry zICCTC6GZAgAbjgCQzCE+v0NoLgGEyIGYwBoLPhnUFiCruDpP5GH/yQIjGUgCHPwgjg2BC0pWS74 hEHwhu/BFDSpgwrQBesdARy6Az64khMPADvggji2A0MIgEWIgnHghTH4BH+AIyioKSgTAy7IZGeY KnSYhE1Ah2mggA/YAAw4gGUdgA6oIykIdHkAA/IZ80F/htX5hEz6BLehgjvAB3zwB3yQgyMoqA+A gQWfajaEUQgPAmf5nr7tAogm7C+GB9vYh16gY3+wgvQBBSvo52Cogjge6aP2hDmqAKIOAO7O5DtQ gvxOAqA4hM3Y6WWg9TvwAjkIgHtwr85ygLYBBSWoAj2xmGewjVEwgszGB41ZBTnYaWEgiADohTko CGP4cn6IBdfmh/9WkPY5WHhQ+Gd/yJnteANhOIRVOJ7fioJnwIcrcG3osIJt3wKl7l8KN/cA8Icv 6GdhSAJ3PxpOeAQ5SIIq+AghoKiwMactKIYAmIQfgA9nGGp0CIBEWAECyACGfQAOiDkaiAJz2Idg uALy4Qew6udmMAx8ECCuT4IJ/wPykQcquIsYAPZcZPBhFwFAuAed/4PtkAd8SIL6pYJZaJt9ICB+ aIJ/1vq/b4VnGYYleBY7OALbuAcoKIZ0GAeLsQMjQBM7sAI6xvd+hoYgAIJ+HoRnCQaXxwcqyPBT +IF7/wIhmAKIvgN+WYd1iAfwWQZ3MIftGIYDGQxc+JKGB2gniHj/2AZoIoj46piHeaAHepgD08+d qYu6dfAHfuCH7egGMOjnQk98JAAKZSAfb2CCwS98OQ6GDnn5Oa5jmKgobRuBBniHSXCAH9gCoPu5 L9aHEPAACWgBA2hWqXeGfViGJaAFbwEIfk2YgAoQ7E8AUEqq4DPYLCEtMP4CMINSYUUKDhwIEMCR w4OHFCk8rBDhzBOSJFUGBUioZFmAfUm8HArgLlgAfkX25IQ1LCcRfgH2DCkoTJWdAPd43dsH516A O6qg2qGCExQYeQEafXnTcljBYVdw4iMjRcyWH88SfhHipVqAdUFgBngz80ovUP7mCN2jLIC/InRa GjOWUxZPfq4S/zshllNYSzpFypRhEsxRECRTjkhJ+oYJEWs5wRR84+VOAHy3evFjp8maq6AB4syZ KHZOI3cBvP0E9QWJkRIVKJAQt60EFCgNdOkS8cpZgE0XYWTgAOJ6iArFPvEJ8gXvRNqAlbyZ+Mar PyUPQUUsyMfiig4bNHb8CHLkihAnuVBBUiUSW1Xo1kwSug2SWCyJlZGYbHsQFEAvSKB2Dxz7BPBQ XatAxQcXqLHnSACagNFIiEwINcdYqXnBBRQOqMXWGzVRCESBu72xzCC9TMRIZFh0EoA0ogVAh2H+ 0JHYTjk1FoAoWcwTwDnE7CHNg4dodgQXlLijxBCwxNFSI1pdsv9MJWyFE0A43XQjTRH0BNCNkHvM QU8cPzVSW11UREFDBRVsE4AngXpCQiKJTCACOgEAYkoImYAjAgUTTEBBMfoE8Ak+oDjyBYDKsIRN FUlcE8AyD10jRBINHZTaGA5cJB99HoEUEkkhFLLJD1FIQQUZlciDqhzcxBOPO81csQc//MSBrLJ/ 8NNJHMnKCQoof1jBxz3xUPHMJ+Y8sg83SDBzDzyBAJNpL0vkJo88kdAyB7V/KPEHPvIgIcUWYTjw TDzy4OOPPNwsIkUXVMDBDT77rHOHEo2Aokk3/oSz4DwSz8OPMspIy+yyydKhcT1Z0BFOP/7Mw8gV keAjjGZc8BL/zyFVfMfEPPRo8oc8oBSLrmj+CIWmMp34Yw09/AzTCyagtEvLFQ7L8x6fgoTSzjub BDqCIJlQLU4xW5CQTADpsDAcBSJYPaw8/sRchTfy0BPJFUFM0QU3nMTziBdeUHGHOeyacwcXp7w6 30ay3pdCDCCIMEIDDYTxgxRcqLIKFXNX3gUZVzDdyhBgLHEFGF+AMcQQn1+hhBBCBAEEEj8YIQXB mhV8xA9Q5FuCA0BUsbvqulvxuxWhrrKKZlGEQUNaXQARBPNIbJFWrlxMwQUqXOy+BC1MNDFQ9k3U UksZuNSifS2kM1FLK61srz0RRJSBBRblX9FWFUBULv0USHiR/4QQ3wVRRerqRwYvBOEK4WBHLIjA o05sbyCkA4MVhIC6KkSwefgigQg4oAAK0CA5pxjBBBgAguyQgASmSMQogBEGElRABBWgQRSooJIq rG5/AVRdcoyACthx4Qi6moUqqECFLkSBBCH4AAEIV59ZieQDMgiBCytwAxbQ4HFRSA4UovCDH3hB CLvbXRJUMhP+qW53Xhhe5TbTOOTUrkUNMMUIRtCnCpxiiEK0IxKQQIUxdKGHR/Ch11hAgi0YoT95 QwILX1GBEZTgeacoQRdWEQRWKOELS0CdFZagySuATpOXrOQnNWlJTmouIkoI3iE380dFFAwJZKDR EQpGBVX0kf8/V/AHNtpXBn+wgwlDmF/qkkCGVZwRCcQTIotKwAIPSCABExgBDWgwAgqs4AMLWMEI XQgPQ0TBayNwYQenMEAv6HFuecyjnipAggaUoASnaAAJqrjF2tGAmh5I4nyWyEQVxEAGIJjAdbK5 SDkOFApD7EIqutCFKTB0evhz6BGMYIQruqgB1xEBpEJAAQYsYAEfUIEKFPCBCmARi21MzvOe14Cx 3UCdaXldRCsQA48uYIQUuGkJYpnHAepxDOMMY97yRoYBAiFvQCgqGsI4w5mQYQxC3IxEJSqFP0qv iGF4ngO24LgjCEEe7mACE0j0h0tWQW9U4IIUohqFiW7RAdL/ZEAGMkAKBWATBCtQQAcIUIAOdMAD CiDBJKJgBq8NZ3HIgV1Ef+CitUbhilAIAQMmEILJAlRxFXiFIkMQA7xyYAOEM9x9PKCCD6zAox+I AWqvwwAZYDMEWdTiPJOzxS1gMasqbQANShhPEHQgBQngawc4QApSSKC4xqVAHJPLgjiyYGzJbeFk KbBIGrhzCx9Mokb6qoDtzmCxr4OdrqjKhfHij7wNPa9CZcnQ8f5RCrDdokmjUAEozlEEUIyChPrm jpt9oaxnpWg7GxdN3ZJgBCGAAAYwEAFSEICvMNiABiKsgQhIYAHURYs07QtFaJbgqiXIbTwbB8/l /jYBtBIJ/z9XUFoVpKAA+PysfQ4nWhUwcSRMBMkIThGGU0TznetsHIFJ0Fw5yhGjGK0AB+KqZARj oAVOvsAFDhAByU62ylTWaJVDgJ2y9ekVcayABjIQgQhogHAc6AAJTqHmq6ZUDMkxgxleC1vGrnWi jW0s7MB7Z8diMaXP6yhqSxsDa/4glsvzYqiKp9USPreFRrbvBlCAggMgAAJKzkCCEYAAKEvAhSMY MqQAqtE+xVGRRp6joxdQ3A1IgNUS2Mhe8zofz3pWI6ANiUhEAlwYcKQDBXAxBz4AYhOaAo7JJSiq MXrTSElqsiBogQWibQEDUPsE1j7BALItARVzu7TXXAEDwv99HRXLoNnRvSkHWpBgS2dAwiIwRXN1 G03qdjgMbPazA0qq730nBy1+bmc7WZCABOTawQqgrRRmYcxj0k6Z9YXUTSUlcRVQu+IGkLYFsq1x FCROshgNwQxAwNGAgmAGVpbUsqucQXaPmcwaaHVxX05rGM8K17lOgYM5whGNbEAEQx4BZhWJaken nLKVJbkKND6ABzD9ASZ4ugCi/oDRfqDqVkftTDvKbX+SXOIKuECCw67kkQadufGOZzQBrnY/s73t bt+C2inAV53zPAbUdUAUUIEKiSr2jWSjgNGPfh0MYDvbTX+6CaKu+A5YE5shB4EMOPptcpM8oBKP LgPCzu7/uLpcwq2mNQdubXNdz53uHIhBc5cLdMwOneg3Pbngr0MApR8e6orHgNVzj/WOTp7rXZfs BRAQdgwoGQaXxazZBYn2tKu9kW9/ftsBHp8O8HrnPY9nh/Ntu1MwWtmANzrJOWCAwi+d6YhPfNQl YHWtqzjr7Kd85S+vUQpwQOyXlnCEP19r0d8c5znfeQF82s+tXut53/eFgMRVHuRlgMbVHvopHgHk XtXt3vvV1e+FgAaAnebFlQYcn5cJ4NnNW/M5H/SVINy1kwcAF90RQAjOGzx9mQEG3nUswAGMH+2Z n+3hngSeFgVO3gr4nuWZm0ZNAJNdmpjhn/7NB//d3K7RbR0IpJ7qrZ7QPRzEfV8CVp4MxMAFGB4O 2l7UWcAO9mC3AeE/SYoHaOC6KVl2IF/ylZAIjqAJlmDA+V9e7dwCpN4I2ELqmUKyVaEMgkAGVNsN Oh3UWQDVSSDWud8YKqD8zV8CJJgRdp7MgR4OBAQAOw== ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://cancerres.aacrjournals.org/icons/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAQAICRAEAOw== ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://cancerres.aacrjournals.org/adsystem/graphics/1217262986135/canres/MolDiag256x80.noabs.jpg?ad=17766&adview=true /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAAPAAA/+4ADkFkb2JlAGTAAAAAAf/b AIQABgQEBAUEBgUFBgkGBQYJCwgGBggLDAoKCwoKDBAMDAwMDAwQDA4PEA8ODBMTFBQTExwbGxsc Hx8fHx8fHx8fHwEHBwcNDA0YEBAYGhURFRofHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8f Hx8fHx8fHx8fHx8fHx8fHx8f/8AAEQgAUAEAAwERAAIRAQMRAf/EAKQAAAEFAQEBAAAAAAAAAAAA AAMAAQIEBQYHCAEBAQEBAQEAAAAAAAAAAAAAAAECAwQFEAACAgEDAgQFAQQGBwkAAAABAgMEBQAR EiEGMSITB0FRYTIUFXGRQiOBoVIzFgjB4fFygnMXsdGSorJDUyQlEQACAgECAwUHAgcBAQAAAAAA ARECAyESMUFR8GFxEwSBkaGx0SJCwQXh8TJSYnLSkhT/2gAMAwEAAhEDEQA/APDE8dfeNgJjvK30 6aAhoBaAJoCY8NAMNwd/3aAJv/F8D0YaAZhsfp8NANoBtALQotAQPidCC0AtAEB6bHqProUiY0Pg dj8joQgVdP2aAkspGgCCRWGx66AkRvsVPUaAY7H7hxb+1oCMsZI5fH4n56AGrbdD4aATDb9h8NCj r4aAmn3b/LroQGvVtAS0A+gHB6bHqNAOjeY7+GgK7HdifmdANoBDxGgCbg/Q6AJsRoBjoCanZP8A RoAiV53ACxswP2EKTvqqrOds1Fxa94IowXlseO+3L4b/AC1IN7lMcxcH4F+J4AhS23Tc9QN/6NIG 5TE6jFWG24I3G43+WkBNMWhSDeOgHMUof0yjB/7BB369R01YZlXq1M6CRWILbHZfE/Ab6kGpXAIs MzbcUY79RsD121drMvJVcWiHm3IAJ2+76ahqUOCRoUYqjeI4n5jQhAxsOq9R9NAIGQKWAJVSAW+A J8N/3aQTcpjmEWYEddChFjZwxj3IUbsNtwBvtufl46sEdkol8QTQvxLhTsv3EeA0gOymOZBW6bHw 1ChGikjC81KhxyQkEbj5jVagzW6cw5gbwVj9NQ0QTQEtALQD6AYfYToAOgFoCcKF5Ao2BPhuQo/e dhqNwUtLjrDnYNEW/wCdDv8A+vrrDypdfc/oIJ2Mdkqic7FaRYT4SlTwP7G8NKZqW0TUhplfoSOP 7tdCC0Bp0LsMcVZJJNjHO7sNidlKKB4fUHXfHdJLxPmeq9Na1rtLjRJeMsL+RjDEDspbiWZCp29T 0QPDbb+81d1I7dPqc/Jz7ucTHH8d/wDz2kDZnptREETKpZ4WK8SCOMbK5Y7bHzHUtau2F3HXDiyr Lusm9Lc/8k6x7Ak9zHSbN8YkkihV15bgAekfD57+Oq71fb3HLH6fNXT+51bhx/sSlnwoLBFUoG5L 5DuR6wO25H/x76rtTt4/QlMXqtJmY6/4f9QQ9TCiVeTKV48XARtju0h3B4777cfl+3SaT27w6ep2 uE5nTVdK98f3dfAD+bWXIy2gxPGNRDxBBLlVQ+I6bdfHWd63Nnb/AOe7wrHH5OfCW/joHaxjFjnh jY8LPNydjsp6NGpG2/RhtuPnqu1dV17I51w5262a1pC8eVnx5r5DfqFZbM85l5RyRkRwDmCvVdl3 22HQdNjp5ilsP0t3StIi1ba20146/wAwUFuoMjdklkDwz+DcTswMyMfKB08oOpWy3Nvg/qayYMjw 41VRavfw+yy4+IYW8cFlVeKrLCocBPFlm32HToTH8fn9dXfXXw/X6GPIzPa3M1s415Onj/d8O4T2 cTyPGNB54uuxbyBn5nbiu3lK6O1PkWuH1Eat8Le+Kx+T5z/IUUuGNhHcqqcVEgCHb7238FJ34cfD 9+qnSSXx+pVGlMy417l39Z4+4ZruOeKMWCr7CEFQhBHBXDctgARyK6b6ta9xH6fNWz2z+fPq6xz6 SQEuHKkeQuQRIwQgE+k2xToNvPx/2ak07eBry/UTKmOWv+S466/bPX3jy2cbHWlWFx6jxPHvxKlv PEyb7KBv0b/v0dqw46fQUxZ3dOy0Vk+PddPn4fQDHbqslQSycYofLYr+bd95CxYbdD0I8T8NZVlp PBHa+LInd1X3W/ptpp9sR7/mWI58NsBIIzIeAkdUYKR/M5cQR06FNbVqc+3H+Bwvj9RymNY1U/jE 6/7E3tY+WPeRVkkEMSKduIHGPZttlPUP/t21Her49F8hT0+ar+1xXdZ9fy0/JaR/KQU8+MEU49Jd yoWM7FQfJ4jyt1Dn6fu1HampuuLPNZb468+fitNvj7x5J8Qwb0uCyecRMUPAdUKlht16c/hqu1OX bh/Ezjx+oUbpa0nXX8phz/qAttRaCFYEHJePNgTyPlHLccQPu8Op1i7rCg9OCmVXs7PTWOnHTn07 kWjPiFZyFQ/d6XkbYLzQorAjqwUNuddN1O3sPJ5XqWlx5TquMWlrunbp8DKsel68npf3XJvT/wB3 fp4/TXC0TofVxbti3f1Rr4g36IdZNmpgu1reTie3LItPGRf3tyXovTxCjpyOvH6n1lcb2pbrvkjd aSaNezgo7kOO7fxJy+QndYYZrQL+pIx4qI4RtvuT0321yWHNfXJbYulfqWUuB0GS7a90KI7geWKC tW7ZMK5NoEhESvOF4JGeO8jbOu4HhpX02BxxbfVsz5jM3J0O6sbDG3cMtCCaYKy426IWtBHG6s8M aNLD06+fifp4a15GNf0bvY39YG9srenNVjjtVJP01rBIjmhl9WlKw8UbkWMZ+j7j9muUqzdbLfHV RZd/f7DXAUNXGZ6Z6U0S4vPpuEZBxhmZfFWT+Fv2f6tLXvgW5Pfi+K9pYT8TnbdazTtSVLkZjniP F1P+j5g6+jjyVvVWrqmc2oO4wftPYy/txkO9IslGn4DTAY0xkvItdUaRlcN8Fk3+3XO2eLqpJLHe Pszm8BdwWOoz/rWVzazb0a0RDRSVwnqISWYNxLnkem3HrqY/UK0zpAkD2/7UZKfK5nG9xxz4mfG4 WfM1wFV/WEToiANuVKMXPmUnw1b50kmtdYEnNXOx+7qmAh7hsYuePDT8GiuEDiVkPGNyu/JVc9FY jY/DXRZKtxOokvS+1/f0U1eCTCzrYtRtLDXJT1eCLzZmj5c02Xr5gNZ86nUSX8F7YXLWEzeTzKz4 4UcOuZxg4qRZic7Rt1/gb56lsyTSXWBJkT+3He9bH0slPiJkpZB4oqk3kYM9gAwqQGJQvyHHkBrS y1biRILIdldxYnK0Mbm6cmMnyEgjhWYDlsZBGX4b77A+G/j8NVZE1KB2HdHsiMXSzsuK7hrZi92z s2bxwhkrTRRsvL1E5llkAHU7H+vprjT1MxKiSSZOS9q8/Y7ilxPbeNvWvQggnmS4sMEy+uCV6c+O zcTw67nW1mUS2WTNxftt35lY7b4/B2rC0LH4dvinWOwCFMZB2PJSRy28PjrTy1XFiQlH2u9wb8Ek 9PBWp4YjOskiKCA1Z/TmXx+5WG3HxPw1HmquYkrVPb/vO5gH7grYieXDoryG2oGxjiO0jqu/NkQ/ cwGw1p5apxOok0cT7Q9+5SziYVxrVY8y6LTsWCFXi6NIJHVeUip6aM2/DwGs2z1U68BITK+2F3FU s9HZguT5TE34qVZ60SvUlWaQJG5bl6gMu4Maheu+srMnHRiSifa/3BTKJiXw0rX3hewa3OIlIo9u byEPtEF5DfmR46151YmRJHtPsz9U7x/w7kYLqTx+ss9ehHHPYEkKkkKrMqEAr1PLw1b5IrKACD23 77nwr5yHC2XxEcBttdVQY/QBO7g79QOJ32082sxOoku9jdi/4gx2VzORyceF7ewqxm/kZI2nbnMd o44oUKl3bb5j4fPUyZdsJKWw2Kp2Fl89fvQ9nRydw4+mYx+asYrFvUTnx9KV9+Q2YcQT4aeckvu0 EkMZ7Yd85al+bjsHasVgJSZUXpvXbhKvUjzK3Tj46ry1XFiSlJ2L3ZFgYs++PlTEzkCvZbiPU5OI wY0JEjgswG6rtq+ZWYnUSXbPth7h1MhRx8+DsrcyXP8ACgAVmkMSepIvQnZlQcirbED4aizViZEm JmMRlMLeahlqr07qKjvBJsHUSKGXkB4HY+B6jWq2TUoBMLijlcnVo77LK/8AMYfBFBZv6h01y9Vm 8rG7dDVVLL/fGa9a7+kUx6WNx59JIl6AunRif909B/r15P2708V8y2t7amsluR0fYnb1SlXjFq1L R7gzlZ3p2Y4FmGOxnE+vdm5ywemZY+QRgSQm5A3dDr1ZLT4L4s5Hv1TK4a97pd3UMjOxpUP06NqT wJFWWSSzA6yGQSuZXkk4Bi0a+UAeC68bTVE13kPmLvWG3/1BzidwPPDaN+wbL8BI+5kJXoWQceO2 2x8Ntte5N7FsSfwNIn3LD+nYmpjaimXGzP8AlpeJ39WQpx2AAHDiPhrx+jt5mS17aXX27ei/U6X0 UGBJbctXmVytmDZQ4+7aPYxnf5jw/YBr3LGtVyfZmJOu75hS7hsVmyoEsyJHNt8S6cx+4htfJ/bb bMl8XJcPkdcmqTNfsf3cxfavb+Ixk1Ka1+JkLlnIIFQxyVrdT8fgu7ruwbZuuw+uvdnxNtvuODRa pe/eOktYWbJ0rMskUedgzMsfBX45mz6yNWJY7mJQF2bb5DXHynr7PgSCMXvL27RRcbUq3JsdU7as 4GnZkWITST2ZYpDLIgfZYx6RAAYnV8uz98lGzfvVib2CievDJVy/4NOjap/iQvDMabKRvZ9RZRGQ u4XgdjosbTBYi93ex4vc2XvlYcmzZSGWHIUXWHaD1K4i3ik57v5lHQgbD92rsts2gr5T3s7bmwtz FVaN0I/bMPbtR5RETzgOyyycX8CoG+w8fhqbLT7ZBZyHvb2UmNahhsTYpVJLmJupSjgqxRwLQkWS aP1EKyTNIyluchPU/AaLHbn3kPPu4O8IMz7i2O5lSYVJryW1jk2MojRlPH7iNwF2Hm13xpqsFO17 r94u1pJO77vbtC8Mt3jGKtyW8Ylhr1uAR1iSNnLM/wASx6fD68VisoT5CDQb3w7Inz9zNy4mylwt jTTtmCrPOIqX99ComLpF6nwkTzaz5dogh1PYffWMzyrlLVealjcb3Hay8F82akChJIdnjtRyS+r4 S+Uxqwb7dxsxGLprTugHLYP347dxV7GNJUuTx42/mLMhiEZWRci0phKBpF+31By321t4259gM/C+ 83b1PDYmxNTt/r+Ew9nC16yen+HMJzskzsTzXYb8l4nc606Nt9GyhLPvJ2vt2jZkpz5TLYG5UmsZ OWtBVs/iV0Cmtzjkf1tj9pbb9++ipbXowDpe8nbeFnzr46patjJdw089AsyRxqqQTixLCxDsQd91 RtvrqeXZx4QCOJ9y+ycZ35le5KVjJfiZxbDZLHWqVazC62JlkNV1eYco9uXmHUdB1G+rts6x0Bjd ke43b/b3unP3WmOlgw5Nr8bH1gnKNZ42RFAZlUAFvAN0+Gulq2tTbzBsUPerCVO3qGKenbZ6nbd7 BswEfA2bc8MqSLvIPIFhIJ8fprnbG5nvkGD2F37g8d2rn+0+46c8+Gz3oubFMqJ4J4G5I6h/Kw34 7j6fXXW9W2rLigbvY3uJ7c9nc2p4+7PLBkq9ytkZYKctqWqkKrLWJfcQD1w0gaM8iNlJ+Oud6WsD Q7d9/cBjbOIlno3ZFx93L25lQRnkMk0piABkHVPUHLf+jfWLY259hDBue5/bV2n2hkmr2o+4e0Ya VaOlxjalZFKZHDO5bmnJFPLZDu379dK1tLXJlOqb347bh7lp5aBLZojIXMnZx0dStCyzW6U9bn6y y7yvymXkSB0HzA1zeK0R3Eg8VlsSWbk07Fj6sjOS/VjyJPU9euvbRmjouzLMdXO1J5SFid/QLH4N KjBP/Mu2vL+5UdsTS48fcdMb1NDFYFk7qztu5BFYq4hHuz15YJLRkjlnSKMpBHLX57GdWO8gUDff fwOsGVWxVjmoM3UM7nI9qZjuTLXalfJ16l7uRcVLZC1DB60M8K2BXhLWZivpRbSGFuHIpxXoEBqu qrhwkwXpcjatw5vKST17U3c1KpkMlzxrKzQTP6UEagZEAcHrciBv/wAXgIlELp3/AMANku0O4c5A uLy2Tx2VupJFWo5iaoPy5KhaVQ8NlZo2leJK0rPFOOS8GG/IdasiWqTQOfxft/lHgjxsV2O1QsZD H1hHYrHnGmQjhP5Kqsu4SKW3HG/m8W6fEa55KVdt+qtD4M0r6QeXCGV7q10iYyyMFiRl4sef2eXr tuCNe52SUvggdp35LDRw2Lw24aSMK7fsjQoD/wARY6+L+1p3y3y8n+up1yaJI0+yMf2Bb9ve4Mzl e3HvZDtw1jNN+dNCthbkkiqAiLtH6Yj+u/019LNaysknxODNfuD2owGU7Dw+YxFirj8jR7bGXyNP hJ6tpUHKSUuBwU7dB8z8vHXKuWLNPqJMm17BZepjq073k/MZqP59RoJlWBMi4jjKTMBHM0ZYeoqf bros9ZEgU9mKUvdljtpe4FsWaKM2QlpULdpIX5hURuC/FTyZiQq+G5OnmrbMCSzW9hJRbyFbJ5+n j0x2Vjw7SvHLJ6k06I0JjCD+MyqCG228SemjzrSFykSRp/5d89NHaFm9FWtJbtUcfGIZpI7ElRSz u8yjjBG22yM/ifhqPPUSUKXsfkrWLq3zkYIhZw1zN+k6PySOlJHE0R2/iZpeh8OmtPNWeHOBJ12H 9pe1Ic92fVw9qtlrmZx0tyzDlIpzWkBgZ/WQIIWVE47KpPLfx3GubzOHOkCTzfMdgVsR2ljM3k8r HFkczD+VjsOkMju0HPgHkl6Im48wHXprssm60JA7HtPtn22g7BwGY7jw09+fNZaXFy2YLUkLQpsO EixjdHK7+HTXLJa25pPggFt/5crTZ3MU4cmK1CtkFxuLllglmaaWSBbKiYwgrCiJIqtK3l5fDU89 QtBJiUfYzJy1KF6TJV4qVmrkLd2wVZhUOLcR2I5NvFubbL8DrXmpfD4iRr3snlafZ36/JbT8taEW WlxvoygLTmbZSLJHpNKF8zReIGtLLXdAk6z3C9m8JJ3tmpq9qt2z23Smo0K+0Uswe3ajUhFRNyPH k7E9N9cseX7VzYkwMd7A3JpbEeUzlTFvBmf0BQ8c0vq2WiSSEx8B4S+soHLbb4/LXR51yU6SJFg/ 8v8AcviMXs5Uxs02Qt4qGF45pTJapqzEKVG3BlRm5Nt0+pA1LZ0uCEkq/wDl+v2GxktHN1ruOuV7 1m5drw2GEC41xFY4RFVkm/mngnFRyP021fPSnQSA/wChFlMhkYrear1MfRq0sgt6aGYGSredkUmE AypIhRg0bDfcbaeeo4CS/kPZntzBdtd6y5fMF8z25PVr1zDHKIF/I4SI0q8CSZlbgvFvKfu6bHUW eXWFoxJ5BwHw8NelJFJiKMjzLv8AUeOrsQEaqn7Dv9D46bUCPpbHYjY/XTaAsbBdVIFuvYhj2ScE 1phwm4/cvgQ6/VSN/r4fHWMtW1K4oqOgmybOlcZOxJVuxoVx/cFUsRJGf4ZOOzHx67eYfEeOvn46 Orbx6r8qPk+7tBt68TLsR9zhEjhuzXq8RUwmtO0yrw6oQinknH4bqNteuuenP7X36Gdoft/NWsXZ kkyMNm1CYYq6xetNEUjSxHKygqR5TEsiBfAct9dHFuDRILmc7txd2lHBjcbJRlaRJ7Ev5UrkSJzY mMuz9WeTcs3Xp8yTpWjXFkNfGd5YiSGrAmHvWcwkKQtaju2OUhBUueIc7KwUjbwG/L+EA88i2ptt KoSkNYTHYS9a7iyiAZK0SaONDmV4124jd23LNxHmfw8dvlr5eTLf1T8vH/Rzfb5HZJV1fE4DLZK7 k78t20d5ZT4DfioHQKv0GvsYMNcdVWvBHJuWW8b3blsX27msDWSI0s9+P+azqxkH4rO0fpkMAOsh 33B0yY02n0Iai+7vdseKOMWKr+OcM3b2/pycvxH23bf1P7zy+O230153g598kgJa94+5rdeobdOr Pkqf4oTJt64lYUpEkj5Isqwkt6YVm4bld9RYYEAqXu13LXu9w2pKtOyvczwzZGtNG7RerWk9WF0H MN5HO+xJB+OteTou4QdVU99JV7by1u9Wq2u5b+cgyv4ksDtW2rwxojqeR4srx7/d/Udtcnhc90CD nK/vT3Wa88GTr1stHLblvxLZ9dPSmn6uFMEsJMe/8DEjWvJ6CBVPervCr25WwccNNoq1KxjFtPEx sGraYO6Fww/iVT4fAb/WvDLkQSxfvT3VjjgZoalJ7vb1aSjQtyRyF/x5I2j9NwsiA7B/H5jR4Znv EGZb9w8nkO16WAyVCnbGNiNbHZGRHFqCEuH4KyuqHbbYclOw1uuOHINPBe7eeweApYevRx9mDHWX vUZrcDTSRWXG3qru4Tkv8Pl6auTDLnUQRxvvB3TXrXq2RSHMV79s5GRLfqqVtMoQurQSQsAVABXf bprm8PQQVIPc/uqHtC92rE8K4vITy2JTwYyr6xQyRo5Y+QmMdCD+3WvK1kQGyHuhnMj25DhshVrW Xr1FoV8g3rrOtePoikJIsTFR5eTIemnlQ5EGnL7493WslkbmRpY+9Fkpq9uWlNE5gSzUAEUsY9Tk D5RuOWx1nyNNBBrY73rnqdmWHsrDf7qn7kObMdiFmhAWvEkUqMpXi0ckflG/w1i2Jz3QIObpe8ve tc0n2rzSUMjZy0ckqOWaxbR45OezqOPGQ8QNttb8mRBLHe83emPr4+rAtYVaC3ovRKPtNFkpjPYj lIfqObeXjsRsPHR4BBXb3SzqjJx06VSpXysEFaxCosSbLWdpFZWllduRaQ77nb6aqxCCzkPd3ujJ t3P+o1aViHuv8dshAY5FRJKiBIXi2fkOPEHYseo1FhiO4QcXHG223Tpr10KGEbbDWwLg/wAtAOOX gw3H10AxiB+08fofDQEZx5U0BYoZa5SVok4y1nO8lWZRJExHxKnwP1Gx1xy4K31ej6riVOC4LHat nYz1bNB/iazrLH+3hLsw/wDFrjtz14OtvHR/D6GpQeOh2q4XfMzKgHRGrMT/AEEORrLy51+C/wDX 8BC6ho17GreaSS5fYfwKqRIf27nl/XrLfqrcFWvxL9oWTvY1oWgwdCHGxt0Mo/mSn9rEf9u+sr9u 3Octnf4Ib+hzk89izO008ryyud2kclif6Tr6FKKqhKEYbG2kHgdaId52ZgsFmOzc0qV4bHddZbFq FLjWY0/Bgrh5HrNCyRGeNt2KzbqRtsNcclmrL+0GyPZbGJkK1CxnB+T+PLPehhiilkT06H5yvEiT lmRusY58CSNwNmGsefpMdpJJF/avtyHC5VjannvN+iSYid4lhVI80jOgsp6jcWUrxc8iAOo336PN cr2/ASTk9le348rdqyZ9jBj4ybfpQxSTpKl+OmyNGlhkXmJQ67vyHgw3Gp5zjh2gSWF9oe2sSc3+ XclyNaHFZQmYVQs0FrF5GCpK8UfrMrghm4FnHTx21l5W48V8UJMzJeyNPG0szPazkcf4M9ivRLrG gmetVS3xkVpeaPIkoVVRX2IPLy9dbrmmNBJz/dfZuL7b7xrYOm8ufmjaH8uoYmh9R5eLrBGY2Z25 I6jku3mOw323O6W3VngU7F+0ewo+58xVsYeGPEY3Fxy5y1HbstHjb/oMHgrSeowndrBRFRy/UMPh uOW60LXWfeQ5z277Rxk2eqpm6dPKYaeuLeRsLcdBQqLs0s0pruCkiqdlSTxbYba6ZbaaaP5lZbzP a3bGQ7HF7tOjE9jHfjRZaacXheea1LIIzDvKajKyBAVWPlvuR01K2atFiGb7bYHB3jl37gxiTYin UkmtZZppoWpsI3EIiEbKkkssxRURgd+vTx21lbURxKzvYPajsx/TjOPlIxorP64ml/8A1fXwk2TZ PHZdp4Qg9HbyE/xeYcPNt25awSQ1f2n7LloT2JMdJDYyVaGbH0zNMXjsyYc35KlduXleOUoxa0Cv pnb7tHltPbrHaBJ5f2/2bhsn2dnc5b7grY/IYrh+HiJQPVtcv7G7KfoOKt18dh116LWaslHEpv8A aXbnYj+2sub7jSKKd79+olovaFk+lRilrR1o4iYC35EnmMq7cT49Nc8jtvhEOnyXtX26ndzWcbJH +Ks1mlYxdisTBHJHhGvI0ZSZWk+3fc8dn+DAdedcj269tYElLJ+0FDK3WkpO2Kh/S6slQrFG9ea2 mKS9OrM0yS8mHU8I2A5An5HSzQuuv6wJFh/Z/GzYKTGi16mayM3b5W/LBwhqrlEmldYHEh9bycQ3 Req/XS2bWeWvwEhO3vabt68mQxMd9LL2rWGStkQsTzVBae4k8LrDLLEX5Vxvxc9NvDS2VrWOv6CS OE9re2f0S0bd2ZoMtDiZMdeemq26zWshLTdTAZuIDPH1Pqfb8CRsVsrnTlPyElYe1UVlMLTmmEEE cd1L+SqwJy5xZd6ETTmezEG5NsE4dfBeJ6trXnce3KRJyuL7UWr7pY7tfKobNP8AXI8XYcc40sRp dFaUowKsA2xG4O4/bro7zRtdCnpeF7B9tcpnrDJFC9GmsdDIw1rNiKrFet3WiheKa3IkrtDUjaSR OTAt0G/hrhbLdIh4jlKdvF5O3jbY4WqU0ledPlJExRh1+o1605UlKk/2JqgDoBaAmv2jQo+gFoBx 4jQBNCF2tm81VoT46tkLMGPtHe1TjmkSGU7bbyRqQrdPmNR1Tcg1sB7gdy4ieOQW5rkVetYqVK1i aVooVswtAzRLy2RlV+m2sWxJiDLk7h7gkkuSSZS40mRUJkHaxKTYVftWYlv5gHw5b61tXQErHdXd Ux3lzV6QmMQ7vZmb+UriRU6t9odQwHhuAdNlegFF3h3hDOZ4c3kI5z6u8qWpg5/IkE03mDb/AMyV Q7/2mG566bK9ABj7m7jjS4iZS2iZHl+oKJ5QLHP7vWAb+Zv8eW+m1dAMM3mHyS5Vr1g5RGV0vmV/ yAyABGEu/PdQBsd9XaojkDT/AMe99+rNMO5Mp6s6qliT82xykRN+Kuee7BeR2B+Z1ny69EIKGI7g z2Flklw+StY2WVQsslOeSBmUHcBjGykjfWrVT4oFyr3v3fWmpyx5i2xx7tLRSWVpo4ZHBDOkcpdF bznrt9dZeOvQFbFdy9x4eKaLE5W5jorO35EdSxLAsmwIHMRsobYE+Oq6J8UCH+IM9wpJ+pWuGNPL HL68m1c777wjl/LO4/h21dq6AIvdHcym4Vy90HI9cgRYlH5H/O838z/i31Ni6Azdz89aAY37xpLR NiQ0kkadapc+kJWUK0gTfjyKqAW232GpC4gut3V3OXaT9Xu+qzmRn/Il5F2iNdmJ5fcYT6ZP9ny+ GpsXQDR94d2RK6xZq/GsirHIFtTKGRI/RVTs3ULF5AP7PTw02V6AEe5u4moxY9spcNCAoYan5Evo oYiWjKx8uK8CxK7DppsUzANXBe4vdOK7hrZuS/YyM1eWGaSG3YmkjmNcMIRKC27CP1G4/Lc7eOs2 xVagGVJ3N3G7tI+XvNIwhDObMpJFZuUG5Lf+03VP7J8Na2LoAkPdPc8brNFmr8cqrIiutmUMFmkM soBDb7SSMXb5t1PXTZXoBZDuXuLIW6V23k55LuOH/wBK3y4zRt6zWPUEi7OZPWkZzITy3PjoqJAp nIZQwvXN6YwPOLbxGR+DWACBMV32MgDEcvHrqwgDuT3r1qW3csPatzsXmsTO0kjsfFndiWYn5nRK AAk+xNUpDQgtATX7RoUfQC0A48RoAmhBaAZfDQD6Ag/iNCkdALQE02/p0IOfA6FB6EFoB08dAT0A j4aAHoBaAWgFoBaAWgGOgJpttoCWgG/i/o0A+gP/2Q== ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://cancerres.aacrjournals.org/icons/shared/misc/arrowTtrim.gif R0lGODlhBAAJAIABAGZmZv///yH5BAEAAAEALAAAAAAEAAkAAAIKjAMHidsLm2HHFAA7 ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://cancerres.aacrjournals.org/icons/misc/permissions.gif R0lGODlhZQAPAMQAACkpqSAgg/Hx+YeHz8nJ6ff3/ENDs9bW7nJyxqys3Zqa1+Hh87y85Orq9/// /1tbvf7+//z8/gAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAA AAAALAAAAABlAA8AQAX/oOMEZGmeaKqubOu+qBgAdPMABUEDBl3shsYOICAOjgjAYTAkNgmMI3Og UzKLzsGB9jgIkgaGIOEsU8vY8HhHAhZ6B4ijoAA0mLtFHcCoPvE7WDhNhIWGh4iIbUMGCzkEDV+J k5SVlpdNizsDBUsDDAUMmKOkpZOaAj0Qe0M/NGdNCToMoktNBUcMCwAPDQYIQgOpSgwGdMAAWgAI OgRJbwxkWHdBSRAIyDhhZDSaREkPfQoGBgI3QF4FDWACAgVJCQznNII7BwUFZLC2WEXK5QJsKCkg 4AoNBPi2oKFxryAbGTAiSpxIUaKIEYQUECCQoIepjyBJBcC4Q8GbJgsUsQJxVGCBxybYmkBol48U LET1MGmKNvDGgDq9gAgpSYOAgCoRXAVaCkCBAJfLvDyQNcZoEgTcjDpr+jSJwkYC9hw4sI6GU6jd ZtCj4QAQ02RV2hU5urGIrSERNmZdsDECXIYGs2xhBqjm2kFNdfTzwY2NWgCymkLgezTZrjzchBGz bKVJTgVCjP3tvFhZAjIaH+wqV+bkgTqLVfMQ5A1BBLcPDIfczdvQyMdApPQeTvxhCAA7 ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://cancerres.aacrjournals.org/javascript/ajax/xmlhttprequest.js /*=0A= =0A= Cross-Browser XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://cancerres.aacrjournals.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else if (name =3D=3D "margin-right") {=0A= e.style.marginRight =3D value;=0A= }=0A= else if (name =3D=3D "margin-top") {=0A= e.style.marginTop =3D value;=0A= }=0A= else if (name =3D=3D "min-height") {=0A= e.style.minHeight =3D value;=0A= }=0A= else if (name =3D=3D "overflow") {=0A= e.style.overflow =3D value;=0A= }=0A= else if (name =3D=3D "overflow-x") {=0A= e.style.overflowX =3D value;=0A= }=0A= else if (name =3D=3D "overflow-y") {=0A= e.style.overflowY =3D value;=0A= }=0A= else if (name =3D=3D "padding") {=0A= e.style.padding =3D value;=0A= }=0A= else if (name =3D=3D "padding-bottom") {=0A= e.style.paddingBottom =3D value;=0A= }=0A= else if (name =3D=3D "padding-left") {=0A= e.style.paddingLeft =3D value;=0A= }=0A= else if (name =3D=3D "padding-right") {=0A= e.style.paddingRight =3D value;=0A= }=0A= else if (name =3D=3D "padding-top") {=0A= e.style.paddingTop =3D value;=0A= }=0A= else if (name =3D=3D "page-break-after") {=0A= e.style.pageBreakAfter =3D value;=0A= }=0A= else if (name =3D=3D "page-break-before") {=0A= e.style.pageBreakBefore =3D value;=0A= }=0A= else if (name =3D=3D "pixelBottom") {=0A= e.style.pixelBottom =3D value;=0A= }=0A= else if (name =3D=3D "pixelHeight") {=0A= e.style.pixelHeight =3D value;=0A= }=0A= else if (name =3D=3D "pixelLeft") {=0A= e.style.pixelLeft =3D value;=0A= }=0A= else if (name =3D=3D "pixelRight") {=0A= e.style.pixelRight =3D value;=0A= }=0A= else if (name =3D=3D "pixelTop") {=0A= e.style.pixelTop =3D value;=0A= }=0A= else if (name =3D=3D "pixelWidth") {=0A= e.style.pixelWidth =3D value;=0A= }=0A= else if (name =3D=3D "posBottom") {=0A= e.style.posBottom =3D value;=0A= }=0A= else if (name =3D=3D "posHeight") {=0A= e.style.posHeight =3D value;=0A= }=0A= else if (name =3D=3D "position") {=0A= e.style.position =3D value;=0A= }=0A= else if (name =3D=3D "posLeft") {=0A= e.style.posLeft =3D value;=0A= }=0A= else if (name =3D=3D "posRight") {=0A= e.style.posRight =3D value;=0A= }=0A= else if (name =3D=3D "posTop") {=0A= e.style.posTop =3D value;=0A= }=0A= else if (name =3D=3D "posWidth") {=0A= e.style.posWidth =3D value;=0A= }=0A= else if (name =3D=3D "right") {=0A= e.style.right =3D value;=0A= }=0A= else if (name =3D=3D "ruby-align") {=0A= e.style.rubyAlign =3D value;=0A= }=0A= else if (name =3D=3D "ruby-overhang") {=0A= e.style.rubyOverhang =3D value;=0A= }=0A= else if (name =3D=3D "ruby-position") {=0A= e.style.rubyPosition =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-3dlight-color") {=0A= e.style.scrollbar3dLightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-arrow-color") {=0A= e.style.scrollbarArrowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-base-color") {=0A= e.style.scrollbarBaseColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-darkshadow-color") {=0A= e.style.scrollbarDarkShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-face-color") {=0A= e.style.scrollbarFaceColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-highlight-color") {=0A= e.style.scrollbarHighlightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-shadow-color") {=0A= e.style.scrollbarShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-track-color") {=0A= e.style.scrollbarTrackColor =3D value;=0A= }=0A= else if (name =3D=3D "float") {=0A= e.style.styleFloat =3D value;=0A= }=0A= else if (name =3D=3D "table-layout") {=0A= e.style.tableLayout =3D value;=0A= }=0A= else if (name =3D=3D "text-align") {=0A= e.style.textAlign =3D value;=0A= }=0A= else if (name =3D=3D "text-align-last") {=0A= e.style.textAlignLast =3D value;=0A= }=0A= else if (name =3D=3D "text-autospace") {=0A= e.style.textAutospace =3D value;=0A= }=0A= else if (name =3D=3D "text-decoration") {=0A= e.style.textDecoration =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationBlink") {=0A= e.style.textDecorationBlink =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationLineThrough") {=0A= e.style.textDecorationLineThrough =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationNone") {=0A= e.style.textDecorationNone =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationOverline") {=0A= e.style.textDecorationOverline =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationUnderline") {=0A= e.style.textDecorationUnderline =3D value;=0A= }=0A= else if (name =3D=3D "text-indent") {=0A= e.style.textIndent =3D value;=0A= }=0A= else if (name =3D=3D "text-justify") {=0A= e.style.textJustify =3D value;=0A= }=0A= else if (name =3D=3D "text-kashida-space") {=0A= e.style.textKashidaSpace =3D value;=0A= }=0A= else if (name =3D=3D "text-overflow") {=0A= e.style.textOverflow =3D value;=0A= }=0A= else if (name =3D=3D "text-transform") {=0A= e.style.textTransform =3D value;=0A= }=0A= else if (name =3D=3D "text-underline-position") {=0A= e.style.textUnderlinePosition =3D value;=0A= }=0A= else if (name =3D=3D "top") {=0A= e.style.top =3D value;=0A= }=0A= else if (name =3D=3D "unicode-bidi") {=0A= e.style.unicodeBidi =3D value;=0A= }=0A= else if (name =3D=3D "vertical-align") {=0A= e.style.verticalAlign =3D value;=0A= }=0A= else if (name =3D=3D "visibility") {=0A= e.style.visibility =3D value;=0A= }=0A= else if (name =3D=3D "white-space") {=0A= e.style.whiteSpace =3D value;=0A= }=0A= else if (name =3D=3D "width") {=0A= e.style.width =3D value;=0A= }=0A= else if (name =3D=3D "word-break") {=0A= e.style.wordBreak =3D value;=0A= }=0A= else if (name =3D=3D "word-spacing") {=0A= e.style.wordSpacing =3D value;=0A= }=0A= else if (name =3D=3D "word-wrap") {=0A= e.style.wordWrap =3D value;=0A= }=0A= else if (name =3D=3D "writing-mode") {=0A= e.style.writingMode =3D value;=0A= }=0A= else if (name =3D=3D "z-index") {=0A= e.style.zIndex =3D value;=0A= }=0A= else if (name =3D=3D "zoom") {=0A= e.style.zoom =3D value;=0A= }=0A= }=0A= catch (e) {=0A= /* ignore error on attempt to set e.style.[property] */=0A= }=0A= }=0A= }=0A= }=0A= ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://cancerres.aacrjournals.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. For now we have to disable=0A= * the callback until we can track down a proper fix=0A= * (or everybody sanely upgrades to version 6 or 7!).=0A= */=0A= if (navigator) {=0A= var appname =3D navigator.appName;=0A= if (appname =3D=3D "Microsoft Internet Explorer") {=0A= var userAgent =3D navigator["userAgent"];=0A= var s =3D "MSIE ";=0A= var n =3D -1; =0A= if ((n =3D userAgent.indexOf(s)) !=3D -1) {=0A= var v =3D parseFloat(userAgent.substring(n+s.length));=0A= if (v < 6) {=0A= return;=0A= }=0A= }=0A= }=0A= }=0A= =0A= /*=0A= * Acquire table row element to update, initiate callback=0A= * to update table with Entrez Links.=0A= */=0A= var tr =3D document.getElementById('entrez_callback_'+pmid);=0A= if (!tr) {=0A= return;=0A= }=0A= var req =3D new XMLHttpRequest();=0A= if (!req) {=0A= return;=0A= }=0A= req.onreadystatechange =3D function() {=0A= if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || req.status = =3D=3D 304)) {=0A= var src =3D req.responseXML.documentElement;=0A= var dst =3D document.createDocumentFragment();=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], dst);=0A= }=0A= var tbl =3D tr.parentNode;=0A= tbl.replaceChild(dst, tr);=0A= }=0A= }=0A= req.open('GET', callback_url, true);=0A= req.send(null);=0A= }=0A= ------=_NextPart_000_0000_01C8F0E0.F843C2B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.google-analytics.com/urchin.js //-- Google Analytics Urchin Module=0A= //-- Copyright 2007 Google, All Rights Reserved.=0A= =0A= //-- Urchin On Demand Settings ONLY=0A= var _uacct=3D""; // set up the Urchin Account=0A= var _userv=3D1; // service mode (0=3Dlocal,1=3Dremote,2=3Dboth)=0A= =0A= //-- UTM User Settings=0A= var _ufsc=3D1; // set client info flag (1=3Don|0=3Doff)=0A= var _udn=3D"auto"; // (auto|none|domain) set the domain name for cookies=0A= var _uhash=3D"on"; // (on|off) unique domain hash for cookies=0A= var _utimeout=3D"1800"; // set the inactive session timeout in seconds=0A= var _ugifpath=3D"/__utm.gif"; // set the web path to the __utm.gif file=0A= var _utsp=3D"|"; // transaction field separator=0A= var _uflash=3D1; // set flash version detect option (1=3Don|0=3Doff)=0A= var _utitle=3D1; // set the document title detect option = (1=3Don|0=3Doff)=0A= var _ulink=3D0; // enable linker functionality (1=3Don|0=3Doff)=0A= var _uanchor=3D0; // enable use of anchors for campaign = (1=3Don|0=3Doff)=0A= var _utcp=3D"/"; // the cookie path for tracking=0A= var _usample=3D100; // The sampling % of visitors to track (1-100).=0A= =0A= //-- UTM Campaign Tracking Settings=0A= var _uctm=3D1; // set campaign tracking module (1=3Don|0=3Doff)=0A= var _ucto=3D"15768000"; // set timeout in seconds (6 month default)=0A= var _uccn=3D"utm_campaign"; // name=0A= var _ucmd=3D"utm_medium"; // medium (cpc|cpm|link|email|organic)=0A= var _ucsr=3D"utm_source"; // source=0A= var _uctr=3D"utm_term"; // term/keyword=0A= var _ucct=3D"utm_content"; // content=0A= var _ucid=3D"utm_id"; // id number=0A= var _ucno=3D"utm_nooverride"; // don't override=0A= =0A= //-- Auto/Organic Sources and Keywords=0A= var _uOsr=3Dnew Array();=0A= var _uOkw=3Dnew Array();=0A= _uOsr[0]=3D"google"; _uOkw[0]=3D"q";=0A= _uOsr[1]=3D"yahoo"; _uOkw[1]=3D"p";=0A= _uOsr[2]=3D"msn"; _uOkw[2]=3D"q";=0A= _uOsr[3]=3D"aol"; _uOkw[3]=3D"query";=0A= _uOsr[4]=3D"aol"; _uOkw[4]=3D"encquery";=0A= _uOsr[5]=3D"lycos"; _uOkw[5]=3D"query";=0A= _uOsr[6]=3D"ask"; _uOkw[6]=3D"q";=0A= _uOsr[7]=3D"altavista"; _uOkw[7]=3D"q";=0A= _uOsr[8]=3D"netscape"; _uOkw[8]=3D"query";=0A= _uOsr[9]=3D"cnn"; _uOkw[9]=3D"query";=0A= _uOsr[10]=3D"looksmart"; _uOkw[10]=3D"qt";=0A= _uOsr[11]=3D"about"; _uOkw[11]=3D"terms";=0A= _uOsr[12]=3D"mamma"; _uOkw[12]=3D"query";=0A= _uOsr[13]=3D"alltheweb"; _uOkw[13]=3D"q";=0A= _uOsr[14]=3D"gigablast"; _uOkw[14]=3D"q";=0A= _uOsr[15]=3D"voila"; _uOkw[15]=3D"rdata";=0A= _uOsr[16]=3D"virgilio"; _uOkw[16]=3D"qs";=0A= _uOsr[17]=3D"live"; _uOkw[17]=3D"q";=0A= _uOsr[18]=3D"baidu"; _uOkw[18]=3D"wd";=0A= _uOsr[19]=3D"alice"; _uOkw[19]=3D"qs";=0A= _uOsr[20]=3D"yandex"; _uOkw[20]=3D"text";=0A= _uOsr[21]=3D"najdi"; _uOkw[21]=3D"q";=0A= _uOsr[22]=3D"aol"; _uOkw[22]=3D"q";=0A= _uOsr[23]=3D"club-internet"; _uOkw[23]=3D"query";=0A= _uOsr[24]=3D"mama"; _uOkw[24]=3D"query";=0A= _uOsr[25]=3D"seznam"; _uOkw[25]=3D"q";=0A= _uOsr[26]=3D"search"; _uOkw[26]=3D"q";=0A= _uOsr[27]=3D"wp"; _uOkw[27]=3D"szukaj";=0A= _uOsr[28]=3D"onet"; _uOkw[28]=3D"qt";=0A= _uOsr[29]=3D"netsprint"; _uOkw[29]=3D"q";=0A= _uOsr[30]=3D"google.interia"; _uOkw[30]=3D"q";=0A= _uOsr[31]=3D"szukacz"; _uOkw[31]=3D"q";=0A= _uOsr[32]=3D"yam"; _uOkw[32]=3D"k";=0A= _uOsr[33]=3D"pchome"; _uOkw[33]=3D"q";=0A= _uOsr[34]=3D"kvasir"; _uOkw[34]=3D"searchExpr";=0A= _uOsr[35]=3D"sesam"; _uOkw[35]=3D"q";=0A= _uOsr[36]=3D"ozu"; _uOkw[36]=3D"q";=0A= _uOsr[37]=3D"terra"; _uOkw[37]=3D"query";=0A= _uOsr[38]=3D"nostrum"; _uOkw[38]=3D"query";=0A= _uOsr[39]=3D"mynet"; _uOkw[39]=3D"q";=0A= _uOsr[40]=3D"ekolay"; _uOkw[40]=3D"q";=0A= _uOsr[41]=3D"search.ilse"; _uOkw[41]=3D"search_for";=0A= =0A= //-- Auto/Organic Keywords to Ignore=0A= var _uOno=3Dnew Array();=0A= //_uOno[0]=3D"urchin";=0A= //_uOno[1]=3D"urchin.com";=0A= //_uOno[2]=3D"www.urchin.com";=0A= =0A= //-- Referral domains to Ignore=0A= var _uRno=3Dnew Array();=0A= //_uRno[0]=3D".urchin.com";=0A= =0A= //-- **** Don't modify below this point ***=0A= var = _uff,_udh,_udt,_ubl=3D0,_udo=3D"",_uu,_ufns=3D0,_uns=3D0,_ur=3D"-",_ufno=3D= 0,_ust=3D0,_ubd=3Ddocument,_udl=3D_ubd.location,_udlh=3D"",_uwv=3D"1.3";=0A= var _ugifpath2=3D"http://www.google-analytics.com/__utm.gif";=0A= if (_udl.hash) _udlh=3D_udl.href.substring(_udl.href.indexOf('#'));=0A= if (_udl.protocol=3D=3D"https:") = _ugifpath2=3D"https://ssl.google-analytics.com/__utm.gif";=0A= if (!_utcp || _utcp=3D=3D"") _utcp=3D"/";=0A= function urchinTracker(page) {=0A= if (_udl.protocol=3D=3D"file:") return;=0A= if (_uff && (!page || page=3D=3D"")) return;=0A= var a,b,c,xx,v,z,k,x=3D"",s=3D"",f=3D0,nv=3D0;=0A= var nx=3D" expires=3D"+_uNx()+";";=0A= var dc=3D_ubd.cookie;=0A= _udh=3D_uDomain();=0A= if (!_uVG()) return;=0A= _uu=3DMath.round(Math.random()*2147483647);=0A= _udt=3Dnew Date();=0A= _ust=3DMath.round(_udt.getTime()/1000);=0A= a=3Ddc.indexOf("__utma=3D"+_udh+".");=0A= b=3Ddc.indexOf("__utmb=3D"+_udh);=0A= c=3Ddc.indexOf("__utmc=3D"+_udh);=0A= if (_udn && _udn!=3D"") { _udo=3D" domain=3D"+_udn+";"; }=0A= if (_utimeout && _utimeout!=3D"") {=0A= x=3Dnew Date(_udt.getTime()+(_utimeout*1000));=0A= x=3D" expires=3D"+x.toGMTString()+";";=0A= }=0A= if (_ulink) {=0A= if (_uanchor && _udlh && _udlh!=3D"") s=3D_udlh+"&";=0A= s+=3D_udl.search;=0A= if(s && s!=3D"" && s.indexOf("__utma=3D")>=3D0) {=0A= if (!(_uIN(a=3D_uGC(s,"__utma=3D","&")))) a=3D"-";=0A= if (!(_uIN(b=3D_uGC(s,"__utmb=3D","&")))) b=3D"-";=0A= if (!(_uIN(c=3D_uGC(s,"__utmc=3D","&")))) c=3D"-";=0A= v=3D_uGC(s,"__utmv=3D","&");=0A= z=3D_uGC(s,"__utmz=3D","&");=0A= k=3D_uGC(s,"__utmk=3D","&");=0A= xx=3D_uGC(s,"__utmx=3D","&");=0A= if ((k*1) !=3D ((_uHash(a+b+c+xx+z+v)*1)+(_udh*1))) = {_ubl=3D1;a=3D"-";b=3D"-";c=3D"-";xx=3D"-";z=3D"-";v=3D"-";}=0A= if (a!=3D"-" && b!=3D"-" && c!=3D"-") f=3D1;=0A= else if(a!=3D"-") f=3D2;=0A= }=0A= }=0A= if(f=3D=3D1) {=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+b+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+c+"; path=3D"+_utcp+";"+_udo;=0A= } else if (f=3D=3D2) {=0A= a=3D_uFixA(s,"&",_ust);=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= } else if (a>=3D0 && b>=3D0 && c>=3D0) {=0A= b =3D _uGC(dc,"__utmb=3D"+_udh,";");=0A= b =3D ("-" =3D=3D b) ? _udh : b; =0A= _ubd.cookie=3D"__utmb=3D"+b+"; path=3D"+_utcp+";"+x+_udo;=0A= } else {=0A= if (a>=3D0) a=3D_uFixA(_ubd.cookie,";",_ust);=0A= else {=0A= a=3D_udh+"."+_uu+"."+_ust+"."+_ust+"."+_ust+".1";=0A= nv=3D1;=0A= }=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= }=0A= if (_ulink && xx && xx!=3D"" && xx!=3D"-") {=0A= xx=3D_uUES(xx);=0A= if (xx.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmx=3D"+xx+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= if (_ulink && v && v!=3D"" && v!=3D"-") {=0A= v=3D_uUES(v);=0A= if (v.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmv=3D"+v+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= var wc=3Dwindow;=0A= var c=3D_ubd.cookie;=0A= if(wc && wc.gaGlobal && wc.gaGlobal.dh=3D=3D_udh){=0A= var g=3Dwc.gaGlobal;=0A= var ua=3Dc.split("__utma=3D"+_udh+".")[1].split(";")[0].split(".");=0A= if(g.sid)ua[3]=3Dg.sid;=0A= if(nv>0){=0A= ua[2]=3Dua[3];=0A= if(g.vid){=0A= var v=3Dg.vid.split(".");=0A= ua[0]=3Dv[0];=0A= ua[1]=3Dv[1];=0A= }=0A= }=0A= _ubd.cookie=3D"__utma=3D"+_udh+"."+ua.join(".")+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= _uInfo(page);=0A= _ufns=3D0;=0A= _ufno=3D0;=0A= if (!page || page=3D=3D"") _uff=3D1;=0A= }=0A= function _uGH() {=0A= var hid;=0A= var wc=3Dwindow;=0A= if (wc && wc.gaGlobal && wc.gaGlobal.hid) {=0A= hid=3Dwc.gaGlobal.hid;=0A= } else {=0A= hid=3DMath.round(Math.random()*0x7fffffff);=0A= if (!wc.gaGlobal) wc.gaGlobal=3D{};=0A= wc.gaGlobal.hid=3Dhid;=0A= }=0A= return hid;=0A= }=0A= function _uInfo(page) {=0A= var p,s=3D"",dm=3D"",pg=3D_udl.pathname+_udl.search;=0A= if (page && page!=3D"") pg=3D_uES(page,1);=0A= _ur=3D_ubd.referrer;=0A= if (!_ur || _ur=3D=3D"") { _ur=3D"-"; }=0A= else {=0A= dm=3D_ubd.domain;=0A= if(_utcp && _utcp!=3D"/") dm+=3D_utcp;=0A= p=3D_ur.indexOf(dm);=0A= if ((p>=3D0) && (p<=3D8)) { _ur=3D"0"; }=0A= if (_ur.indexOf("[")=3D=3D0 && = _ur.lastIndexOf("]")=3D=3D(_ur.length-1)) { _ur=3D"-"; }=0A= }=0A= s+=3D"&utmn=3D"+_uu;=0A= if (_ufsc) s+=3D_uBInfo();=0A= if (_uctm) s+=3D_uCInfo();=0A= if (_utitle && _ubd.title && _ubd.title!=3D"") = s+=3D"&utmdt=3D"+_uES(_ubd.title);=0A= if (_udl.hostname && _udl.hostname!=3D"") = s+=3D"&utmhn=3D"+_uES(_udl.hostname);=0A= if (_usample && _usample !=3D 100) s+=3D"&utmsp=3D"+_uES(_usample);=0A= s+=3D"&utmhid=3D"+_uGH();=0A= s+=3D"&utmr=3D"+_ur;=0A= s+=3D"&utmp=3D"+pg;=0A= if ((_userv=3D=3D0 || _userv=3D=3D2) && _uSP()) {=0A= var i=3Dnew Image(1,1);=0A= i.src=3D_ugifpath+"?"+"utmwv=3D"+_uwv+s;=0A= i.onload=3Dfunction() { _uVoid(); }=0A= }=0A= if ((_userv=3D=3D1 || _userv=3D=3D2) && _uSP()) {=0A= var i2=3Dnew Image(1,1);=0A= = i2.src=3D_ugifpath2+"?"+"utmwv=3D"+_uwv+s+"&utmac=3D"+_uacct+"&utmcc=3D"+= _uGCS();=0A= i2.onload=3Dfunction() { _uVoid(); }=0A= }=0A= return;=0A= }=0A= function _uVoid() { return; }=0A= function _uCInfo() {=0A= if (!_ucto || _ucto=3D=3D"") { _ucto=3D"15768000"; }=0A= if (!_uVG()) return;=0A= var = c=3D"",t=3D"-",t2=3D"-",t3=3D"-",o=3D0,cs=3D0,cn=3D0,i=3D0,z=3D"-",s=3D""= ;=0A= if (_uanchor && _udlh && _udlh!=3D"") s=3D_udlh+"&";=0A= s+=3D_udl.search;=0A= var x=3Dnew Date(_udt.getTime()+(_ucto*1000));=0A= var dc=3D_ubd.cookie;=0A= x=3D" expires=3D"+x.toGMTString()+";";=0A= if (_ulink && !_ubl) {=0A= z=3D_uUES(_uGC(s,"__utmz=3D","&"));=0A= if (z!=3D"-" && z.indexOf(";")=3D=3D-1) { = _ubd.cookie=3D"__utmz=3D"+z+"; path=3D"+_utcp+";"+x+_udo; return ""; }=0A= }=0A= z=3Ddc.indexOf("__utmz=3D"+_udh+".");=0A= if (z>-1) { z=3D_uGC(dc,"__utmz=3D"+_udh+".",";"); }=0A= else { z=3D"-"; }=0A= t=3D_uGC(s,_ucid+"=3D","&");=0A= t2=3D_uGC(s,_ucsr+"=3D","&");=0A= t3=3D_uGC(s,"gclid=3D","&");=0A= if ((t!=3D"-" && t!=3D"") || (t2!=3D"-" && t2!=3D"") || (t3!=3D"-" && = t3!=3D"")) {=0A= if (t!=3D"-" && t!=3D"") c+=3D"utmcid=3D"+_uEC(t);=0A= if (t2!=3D"-" && t2!=3D"") { if (c !=3D "") c+=3D"|"; = c+=3D"utmcsr=3D"+_uEC(t2); }=0A= if (t3!=3D"-" && t3!=3D"") { if (c !=3D "") c+=3D"|"; = c+=3D"utmgclid=3D"+_uEC(t3); }=0A= t=3D_uGC(s,_uccn+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmccn=3D"+_uEC(t);=0A= else c+=3D"|utmccn=3D(not+set)";=0A= t=3D_uGC(s,_ucmd+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmcmd=3D"+_uEC(t);=0A= else c+=3D"|utmcmd=3D(not+set)";=0A= t=3D_uGC(s,_uctr+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmctr=3D"+_uEC(t);=0A= else { t=3D_uOrg(1); if (t!=3D"-" && t!=3D"") = c+=3D"|utmctr=3D"+_uEC(t); }=0A= t=3D_uGC(s,_ucct+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmcct=3D"+_uEC(t);=0A= t=3D_uGC(s,_ucno+"=3D","&");=0A= if (t=3D=3D"1") o=3D1;=0A= if (z!=3D"-" && o=3D=3D1) return "";=0A= }=0A= if (c=3D=3D"-" || c=3D=3D"") { c=3D_uOrg(); if (z!=3D"-" && = _ufno=3D=3D1) return ""; }=0A= if (c=3D=3D"-" || c=3D=3D"") { if (_ufns=3D=3D1) c=3D_uRef(); if = (z!=3D"-" && _ufno=3D=3D1) return ""; }=0A= if (c=3D=3D"-" || c=3D=3D"") {=0A= if (z=3D=3D"-" && _ufns=3D=3D1) { = c=3D"utmccn=3D(direct)|utmcsr=3D(direct)|utmcmd=3D(none)"; }=0A= if (c=3D=3D"-" || c=3D=3D"") return "";=0A= }=0A= if (z!=3D"-") {=0A= i=3Dz.indexOf(".");=0A= if (i>-1) i=3Dz.indexOf(".",i+1);=0A= if (i>-1) i=3Dz.indexOf(".",i+1);=0A= if (i>-1) i=3Dz.indexOf(".",i+1);=0A= t=3Dz.substring(i+1,z.length);=0A= if (t.toLowerCase()=3D=3Dc.toLowerCase()) cs=3D1;=0A= t=3Dz.substring(0,i);=0A= if ((i=3Dt.lastIndexOf(".")) > -1) {=0A= t=3Dt.substring(i+1,t.length);=0A= cn=3D(t*1);=0A= }=0A= }=0A= if (cs=3D=3D0 || _ufns=3D=3D1) {=0A= t=3D_uGC(dc,"__utma=3D"+_udh+".",";");=0A= if ((i=3Dt.lastIndexOf(".")) > 9) {=0A= _uns=3Dt.substring(i+1,t.length);=0A= _uns=3D(_uns*1);=0A= }=0A= cn++;=0A= if (_uns=3D=3D0) _uns=3D1;=0A= _ubd.cookie=3D"__utmz=3D"+_udh+"."+_ust+"."+_uns+"."+cn+"."+c+"; = path=3D"+_utcp+"; "+x+_udo;=0A= }=0A= if (cs=3D=3D0 || _ufns=3D=3D1) return "&utmcn=3D1";=0A= else return "&utmcr=3D1";=0A= }=0A= function _uRef() {=0A= if (_ur=3D=3D"0" || _ur=3D=3D"" || _ur=3D=3D"-") return "";=0A= var i=3D0,h,k,n;=0A= if ((i=3D_ur.indexOf("://"))<0 || _uGCse()) return "";=0A= h=3D_ur.substring(i+3,_ur.length);=0A= if (h.indexOf("/") > -1) {=0A= k=3Dh.substring(h.indexOf("/"),h.length);=0A= if (k.indexOf("?") > -1) k=3Dk.substring(0,k.indexOf("?"));=0A= h=3Dh.substring(0,h.indexOf("/"));=0A= }=0A= h=3Dh.toLowerCase();=0A= n=3Dh;=0A= if ((i=3Dn.indexOf(":")) > -1) n=3Dn.substring(0,i);=0A= for (var ii=3D0;ii<_uRno.length;ii++) {=0A= if ((i=3Dn.indexOf(_uRno[ii].toLowerCase())) > -1 && = n.length=3D=3D(i+_uRno[ii].length)) { _ufno=3D1; break; }=0A= }=0A= if (h.indexOf("www.")=3D=3D0) h=3Dh.substring(4,h.length);=0A= return = "utmccn=3D(referral)|utmcsr=3D"+_uEC(h)+"|"+"utmcct=3D"+_uEC(k)+"|utmcmd=3D= referral";=0A= }=0A= function _uOrg(t) {=0A= if (_ur=3D=3D"0" || _ur=3D=3D"" || _ur=3D=3D"-") return "";=0A= var i=3D0,h,k;=0A= if ((i=3D_ur.indexOf("://"))<0 || _uGCse()) return "";=0A= h=3D_ur.substring(i+3,_ur.length);=0A= if (h.indexOf("/") > -1) {=0A= h=3Dh.substring(0,h.indexOf("/"));=0A= }=0A= for (var ii=3D0;ii<_uOsr.length;ii++) {=0A= if (h.toLowerCase().indexOf(_uOsr[ii].toLowerCase()) > -1) {=0A= if ((i=3D_ur.indexOf("?"+_uOkw[ii]+"=3D")) > -1 || = (i=3D_ur.indexOf("&"+_uOkw[ii]+"=3D")) > -1) {=0A= k=3D_ur.substring(i+_uOkw[ii].length+2,_ur.length);=0A= if ((i=3Dk.indexOf("&")) > -1) k=3Dk.substring(0,i);=0A= for (var yy=3D0;yy<_uOno.length;yy++) {=0A= if (_uOno[yy].toLowerCase()=3D=3Dk.toLowerCase()) { _ufno=3D1; = break; }=0A= }=0A= if (t) return _uEC(k);=0A= else return = "utmccn=3D(organic)|utmcsr=3D"+_uEC(_uOsr[ii])+"|"+"utmctr=3D"+_uEC(k)+"|= utmcmd=3Dorganic";=0A= }=0A= }=0A= }=0A= return "";=0A= }=0A= function _uGCse() {=0A= var h,p;=0A= h=3Dp=3D_ur.split("://")[1];=0A= if(h.indexOf("/")>-1) {=0A= h=3Dh.split("/")[0];=0A= p=3Dp.substring(p.indexOf("/")+1,p.length);=0A= }=0A= if(p.indexOf("?")>-1) {=0A= p=3Dp.split("?")[0];=0A= }=0A= if(h.toLowerCase().indexOf("google")>-1) {=0A= if(_ur.indexOf("?q=3D")>-1 || _ur.indexOf("&q=3D")>-1) {=0A= if (p.toLowerCase().indexOf("cse")>-1) {=0A= return true;=0A= }=0A= }=0A= }=0A= }=0A= function _uBInfo() {=0A= var sr=3D"-",sc=3D"-",ul=3D"-",fl=3D"-",cs=3D"-",je=3D1;=0A= var n=3Dnavigator;=0A= if (self.screen) {=0A= sr=3Dscreen.width+"x"+screen.height;=0A= sc=3Dscreen.colorDepth+"-bit";=0A= } else if (self.java) {=0A= var j=3Djava.awt.Toolkit.getDefaultToolkit();=0A= var s=3Dj.getScreenSize();=0A= sr=3Ds.width+"x"+s.height;=0A= }=0A= if (n.language) { ul=3Dn.language.toLowerCase(); }=0A= else if (n.browserLanguage) { ul=3Dn.browserLanguage.toLowerCase(); }=0A= je=3Dn.javaEnabled()?1:0;=0A= if (_uflash) fl=3D_uFlash();=0A= if (_ubd.characterSet) cs=3D_uES(_ubd.characterSet);=0A= else if (_ubd.charset) cs=3D_uES(_ubd.charset);=0A= return = "&utmcs=3D"+cs+"&utmsr=3D"+sr+"&utmsc=3D"+sc+"&utmul=3D"+ul+"&utmje=3D"+j= e+"&utmfl=3D"+fl;=0A= }=0A= function __utmSetTrans() {=0A= var e;=0A= if (_ubd.getElementById) e=3D_ubd.getElementById("utmtrans");=0A= else if (_ubd.utmform && _ubd.utmform.utmtrans) = e=3D_ubd.utmform.utmtrans;=0A= if (!e) return;=0A= var l=3De.value.split("UTM:");=0A= var i,i2,c;=0A= if (_userv=3D=3D0 || _userv=3D=3D2) i=3Dnew Array();=0A= if (_userv=3D=3D1 || _userv=3D=3D2) { i2=3Dnew Array(); c=3D_uGCS(); }=0A= =0A= for (var ii=3D0;ii-1) return;=0A= if (h) { url=3Dl+"#"+p; }=0A= else {=0A= if (iq=3D=3D-1 && ih=3D=3D-1) url=3Dl+"?"+p;=0A= else if (ih=3D=3D-1) url=3Dl+"&"+p;=0A= else if (iq=3D=3D-1) url=3Dl.substring(0,ih-1)+"?"+p+l.substring(ih);=0A= else url=3Dl.substring(0,ih-1)+"&"+p+l.substring(ih);=0A= }=0A= }=0A= return url;=0A= }=0A= function __utmLinker(l,h) {=0A= if (!_ulink || !l || l=3D=3D"") return;=0A= _udl.href=3D__utmLinkerUrl(l,h);=0A= }=0A= function __utmLinkPost(f,h) {=0A= if (!_ulink || !f || !f.action) return;=0A= f.action=3D__utmLinkerUrl(f.action, h);=0A= return;=0A= }=0A= function __utmSetVar(v) {=0A= if (!v || v=3D=3D"") return;=0A= if (!_udo || _udo =3D=3D "") {=0A= _udh=3D_uDomain();=0A= if (_udn && _udn!=3D"") { _udo=3D" domain=3D"+_udn+";"; }=0A= }=0A= if (!_uVG()) return;=0A= var r=3DMath.round(Math.random() * 2147483647);=0A= _ubd.cookie=3D"__utmv=3D"+_udh+"."+_uES(v)+"; path=3D"+_utcp+"; = expires=3D"+_uNx()+";"+_udo;=0A= var s=3D"&utmt=3Dvar&utmn=3D"+r;=0A= if (_usample && _usample !=3D 100) s+=3D"&utmsp=3D"+_uES(_usample);=0A= if ((_userv=3D=3D0 || _userv=3D=3D2) && _uSP()) {=0A= var i=3Dnew Image(1,1);=0A= i.src=3D_ugifpath+"?"+"utmwv=3D"+_uwv+s;=0A= i.onload=3Dfunction() { _uVoid(); }=0A= }=0A= if ((_userv=3D=3D1 || _userv=3D=3D2) && _uSP()) {=0A= var i2=3Dnew Image(1,1);=0A= = i2.src=3D_ugifpath2+"?"+"utmwv=3D"+_uwv+s+"&utmac=3D"+_uacct+"&utmcc=3D"+= _uGCS();=0A= i2.onload=3Dfunction() { _uVoid(); }=0A= }=0A= }=0A= function _uGCS() {=0A= var t,c=3D"",dc=3D_ubd.cookie;=0A= if ((t=3D_uGC(dc,"__utma=3D"+_udh+".",";"))!=3D"-") = c+=3D_uES("__utma=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmx=3D"+_udh,";"))!=3D"-") = c+=3D_uES("__utmx=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmz=3D"+_udh+".",";"))!=3D"-") = c+=3D_uES("__utmz=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmv=3D"+_udh+".",";"))!=3D"-") = c+=3D_uES("__utmv=3D"+t+";");=0A= if (c.charAt(c.length-1)=3D=3D"+") c=3Dc.substring(0,c.length-1);=0A= return c;=0A= }=0A= function _uGC(l,n,s) {=0A= if (!l || l=3D=3D"" || !n || n=3D=3D"" || !s || s=3D=3D"") return "-";=0A= var i,i2,i3,c=3D"-";=0A= i=3Dl.indexOf(n);=0A= i3=3Dn.indexOf("=3D")+1;=0A= if (i > -1) {=0A= i2=3Dl.indexOf(s,i); if (i2 < 0) { i2=3Dl.length; }=0A= c=3Dl.substring((i+i3),i2);=0A= }=0A= return c;=0A= }=0A= function _uDomain() {=0A= if (!_udn || _udn=3D=3D"" || _udn=3D=3D"none") { _udn=3D""; return 1; }=0A= if (_udn=3D=3D"auto") {=0A= var d=3D_ubd.domain;=0A= if (d.substring(0,4)=3D=3D"www.") {=0A= d=3Dd.substring(4,d.length);=0A= }=0A= _udn=3Dd;=0A= }=0A= _udn =3D _udn.toLowerCase(); =0A= if (_uhash=3D=3D"off") return 1;=0A= return _uHash(_udn);=0A= }=0A= function _uHash(d) {=0A= if (!d || d=3D=3D"") return 1;=0A= var h=3D0,g=3D0;=0A= for (var i=3Dd.length-1;i>=3D0;i--) {=0A= var c=3DparseInt(d.charCodeAt(i));=0A= h=3D((h << 6) & 0xfffffff) + c + (c << 14);=0A= if ((g=3Dh & 0xfe00000)!=3D0) h=3D(h ^ (g >> 21));=0A= }=0A= return h;=0A= }=0A= function _uFixA(c,s,t) {=0A= if (!c || c=3D=3D"" || !s || s=3D=3D"" || !t || t=3D=3D"") return "-";=0A= var a=3D_uGC(c,"__utma=3D"+_udh+".",s);=0A= var lt=3D0,i=3D0;=0A= if ((i=3Da.lastIndexOf(".")) > 9) {=0A= _uns=3Da.substring(i+1,a.length);=0A= _uns=3D(_uns*1)+1;=0A= a=3Da.substring(0,i);=0A= if ((i=3Da.lastIndexOf(".")) > 7) {=0A= lt=3Da.substring(i+1,a.length);=0A= a=3Da.substring(0,i);=0A= }=0A= if ((i=3Da.lastIndexOf(".")) > 5) {=0A= a=3Da.substring(0,i);=0A= }=0A= a+=3D"."+lt+"."+t+"."+_uns;=0A= }=0A= return a;=0A= }=0A= function _uTrim(s) {=0A= if (!s || s=3D=3D"") return "";=0A= while ((s.charAt(0)=3D=3D' ') || (s.charAt(0)=3D=3D'\n') || = (s.charAt(0,1)=3D=3D'\r')) s=3Ds.substring(1,s.length);=0A= while ((s.charAt(s.length-1)=3D=3D' ') || = (s.charAt(s.length-1)=3D=3D'\n') || (s.charAt(s.length-1)=3D=3D'\r')) = s=3Ds.substring(0,s.length-1);=0A= return s;=0A= }=0A= function _uEC(s) {=0A= var n=3D"";=0A= if (!s || s=3D=3D"") return "";=0A= for (var i=3D0;i0) r=3Da.substring(i+1,i2); else return = ""; =0A= if ((i=3Da.indexOf(".",i2+1))>0) t=3Da.substring(i2+1,i); else return = ""; =0A= if (f) {=0A= return r;=0A= } else {=0A= var c=3Dnew = Array('A','B','C','D','E','F','G','H','J','K','L','M','N','P','R','S','T'= ,'U','V','W','X','Y','Z','1','2','3','4','5','6','7','8','9');=0A= return = c[r>>28&m]+c[r>>23&m]+c[r>>18&m]+c[r>>13&m]+"-"+c[r>>8&m]+c[r>>3&m]+c[((r= &7)<<2)+(t>>30&3)]+c[t>>25&m]+c[t>>20&m]+"-"+c[t>>15&m]+c[t>>10&m]+c[t>>5= &m]+c[t&m];=0A= }=0A= }=0A= function _uIN(n) {=0A= if (!n) return false;=0A= for (var i=3D0;i"9") && (c!=3D".")) return false;=0A= }=0A= return true;=0A= }=0A= function _uES(s,u) {=0A= if (typeof(encodeURIComponent) =3D=3D 'function') {=0A= if (u) return encodeURI(s);=0A= else return encodeURIComponent(s);=0A= } else {=0A= return escape(s);=0A= }=0A= }=0A= function _uUES(s) {=0A= if (typeof(decodeURIComponent) =3D=3D 'function') {=0A= return decodeURIComponent(s);=0A= } else {=0A= return unescape(s);=0A= }=0A= }=0A= function _uVG() {=0A= if((_udn.indexOf("www.google.") =3D=3D 0 || _udn.indexOf(".google.") = =3D=3D 0 || _udn.indexOf("google.") =3D=3D 0) && _utcp=3D=3D'/' && = _udn.indexOf("google.org")=3D=3D-1) {=0A= return false;=0A= }=0A= return true;=0A= }=0A= function _uSP() {=0A= var s=3D100;=0A= if (_usample) s=3D_usample;=0A= if(s>=3D100 || s<=3D0) return true;=0A= return ((__utmVisitorCode(1)%10000)<(s*100));=0A= }=0A= function urchinPathCopy(p){=0A= var d=3Ddocument,nx,tx,sx,i,c,cs,t,h,o;=0A= cs=3Dnew Array("a","b","c","v","x","z");=0A= h=3D_uDomain(); if (_udn && _udn!=3D"") o=3D" domain=3D"+_udn+";";=0A= nx=3D_uNx()+";";=0A= tx=3Dnew Date(); tx.setTime(tx.getTime()+(_utimeout*1000));=0A= tx=3Dtx.toGMTString()+";";=0A= sx=3Dnew Date(); sx.setTime(sx.getTime()+(_ucto*1000));=0A= sx=3Dsx.toGMTString()+";";=0A= for (i=3D0;i<6;i++){=0A= t=3D" expires=3D";=0A= if (i=3D=3D1) t+=3Dtx; else if (i=3D=3D2) t=3D""; else if (i=3D=3D5) = t+=3Dsx; else t+=3Dnx;=0A= c=3D_uGC(d.cookie,"__utm"+cs[i]+"=3D"+h,";");=0A= if (c!=3D"-") d.cookie=3D"__utm"+cs[i]+"=3D"+c+"; path=3D"+p+";"+t+o;=0A= }=0A= }=0A= function _uCO() {=0A= if (!_utk || _utk=3D=3D"" || _utk.length<10) return;=0A= var d=3D'www.google.com';=0A= if (_utk.charAt(0)=3D=3D'!') d=3D'analytics.corp.google.com';=0A= _ubd.cookie=3D"GASO=3D"+_utk+"; path=3D"+_utcp+";"+_udo;=0A= var sc=3Ddocument.createElement('script');=0A= sc.type=3D'text/javascript';=0A= sc.id=3D"_gasojs";=0A= = sc.src=3D'https://'+d+'/analytics/reporting/overlay_js?gaso=3D'+_utk+'&'+= Math.random();=0A= document.getElementsByTagName('head')[0].appendChild(sc); =0A= }=0A= function _uGT() {=0A= var h=3Dlocation.hash, a;=0A= if (h && h!=3D"" && h.indexOf("#gaso=3D")=3D=3D0) {=0A= a=3D_uGC(h,"gaso=3D","&");=0A= } else {=0A= a=3D_uGC(_ubd.cookie,"GASO=3D",";");=0A= }=0A= return a;=0A= }=0A= var _utk=3D_uGT();=0A= if (_utk && _utk!=3D"" && _utk.length>10 && _utk.indexOf("=3D")=3D=3D-1) = {=0A= if (window.addEventListener) {=0A= window.addEventListener('load', _uCO, false); =0A= } else if (window.attachEvent) { =0A= window.attachEvent('onload', _uCO);=0A= }=0A= }=0A= =0A= function _uNx() {=0A= return (new Date((new Date()).getTime()+63072000000)).toGMTString();=0A= }=0A= ------=_NextPart_000_0000_01C8F0E0.F843C2B0--