Archives of Pathology and Laboratory Medicine = 132:1830-1834, 2008

From: Subject: Archives of Pathology and Laboratory Medicine 132:1830-1834, 2008 Date: Sat, 29 Nov 2008 12:00:03 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C9521A.035E9F90" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C9521A.035E9F90 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://arpa.allenpress.com/arpaonline/?request=get-abstract&issn=1543-2165&volume=132&page=1830 Archives of Pathology and Laboratory Medicine = 132:1830-1834, 2008


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Archives of Pathology and Laboratory Medicine = 132:1830=961834,=20 2008
=A9=20 Copyright by College of American Pathologists 2008=20

Archives of Pathology and Laboratory = Medicine:=20 Vol. 132, No. 11, pp. 1830=961834.

Primary Central Nervous System Lymphoma

Sharathkumar Bhagavathi, MD; Jon D. Wilson, MD

From the Department of Anatomic Pathology, William Beaumont=20 Hospital, Royal Oak, = Mich

Accepted April 23, 2008

Primary=20 central nervous system lymphoma (PCNSL) is an uncommon extranodal=20 non-Hodgkin lymphoma. Its incidence has increased during the last 3 = decades=20 and has been reported in both immunocompromised and immunocompetent=20 patients. Immunocompromised patients are affected at a younger age = compared=20 with immunocompetent patients. It presents with raised intracranial = pressure=20 and focal neurologic and neuropsychiatric symptoms. The lesions are=20 typically solitary. The majority of the lesions are located in the=20 periventricular area, whereas in a few cases they are located in the = supratentorial area. Diffuse large B-cell lymphomas constitute most = PCNSLs,=20 whereas T-cell, low-grade, anaplastic, and Hodgkin lymphomas are = rarely=20 encountered. The morphology of PCNSL shows a characteristic = angiocentric=20 pattern and is positive for B-cell markers by immunohistochemistry. = The=20 differential diagnosis of PCNSL includes central nervous system = gliomas,=20 metastatic tumors, demyelinating disorders, subacute infarcts, and=20 space-occupying lesions due to an infectious etiology. The = understanding of=20 the molecular mechanisms involved in the pathogenesis of PCNSL and = the=20 identification of molecular biomarkers have lagged behind that of = systemic=20 nodal lymphomas. Primary central nervous system lymphomas are = treated with=20 combined radiotherapies and chemotherapies. The prognosis for PCNSL = is worse=20 than for other extranodal = lymphomas.

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