From: Subject: Journal of Medical Case Reports | Abstract | 1752-1947-2-53 | Gliomatosis cerebri presenting as rapidly progressive dementia and parkinsonism in an elderly woman: a case report Date: Fri, 29 Feb 2008 22:48:23 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0016_01C87B25.30961E10" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0016_01C87B25.30961E10 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.jmedicalcasereports.com/content/2/1/53 =EF=BB=BF Journal of Medical = Case Reports | Abstract | 1752-1947-2-53 | Gliomatosis cerebri = presenting as rapidly progressive dementia and parkinsonism in an = elderly woman: a case report
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Case report

Gliomatosis cerebri presenting as rapidly progressive dementia = and=20 parkinsonism in an elderly woman: a case report

Emmanuelle Duron ,=20 Anne Lazareth ,=20 Jean-yves Gaubert ,=20 Carole Raso ,=20 Olivier Hanon =20 and Anne-sophie Rigaud

Journal of Medical Case Reports 2008,=20 2:53doi:10.1186/1752-1947-2-53

=
Published:20 February 2008
<= A=20 name=3Dabstract>

Abstract (provisional)

Introduction

Dementia is one of the most important neurological disorders in = the=20 elderly. Dementia of tumoral origin is rare and parkinsonism of = neoplastic=20 origin is unusual. We herein report a case of gliomatosis cerebri, = a very=20 rare brain tumor seldom affecting the elderly, which presented as = rapidly=20 progressive dementia and parkinsonism.

Case presentation

An 82-year-old woman very rapidly developed progressive = dementia and=20 akineto-rigid parkinsonism. Brain CT scan was normal. Cerebral = magnetic=20 resonance imaging (MRI) with gadolinium injection highlighted a = diffuse=20 tumor-related infiltration involving both lobes, the putamen, the=20 pallidum, the substantia nigra, and the brainstem, corresponding = to the=20 specific description and definition of gliomatosis cerebri

Conclusion

This atypical presentation of a gliomatosis cerebri, and the=20 infiltration of the substantia nigra by the tumor, merits = attention.=20


The complete article is available as a = provisional=20 PDF. The fully formatted PDF and HTML versions are in = production.=20

Published by
=C2=A9 1999-2008 BioMed Central Ltd = unless otherwise=20 stated < info@biomedcentral.com = >=20   Terms and = conditions=20 =
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_u5_uRno=3Dnew Array(); //_u5_uRno[0]=3D".urchin.com"; //-- **** Don't modify below this point *** var = _u5_uff,_u5_udh,_u5_udt,_u5_udo=3D"",_u5_uu,_u5_ufns=3D0,_u5_uns=3D0,_u5_= ur=3D"-",_u5_ufno=3D0,_u5_ust=3D0,_u5_ujv=3D"-",_u5_ubd=3Ddocument,_u5_ud= l=3D_u5_ubd.location,_u5_uwv=3D"6.1"; var _u5_ugifpath2=3D"http://service.urchin.com/__utm.gif"; if (_u5_udl.protocol=3D=3D"https:") = _u5_ugifpath2=3D"https://service.urchin.com/__utm.gif"; function u5_urchinTracker(page) { if (_u5_udl.protocol=3D=3D"file:") return; if (_u5_uff && (!page || page=3D=3D"")) return; var a,b,c,v,x=3D"",s=3D"",f=3D0; var nx=3D" expires=3DSun, 18 Jan 2038 00:00:00 GMT;"; var dc=3D_u5_ubd.cookie; _u5_udh=3D_u5_uDomain(); _u5_uu=3DMath.round(Math.random()*2147483647); _u5_udt=3Dnew Date(); _u5_ust=3DMath.round(_u5_udt.getTime()/1000); a=3Ddc.indexOf("__utma=3D"+_u5_udh); b=3Ddc.indexOf("__utmb=3D"+_u5_udh); c=3Ddc.indexOf("__utmc=3D"+_u5_udh); if (_u5_udn && _u5_udn!=3D"") { _u5_udo=3D" domain=3D"+_u5_udn+";"; } if (_u5_utimeout && _u5_utimeout!=3D"") { x=3Dnew Date(_u5_udt.getTime()+(_u5_utimeout*1000)); x=3D" expires=3D"+x.toGMTString()+";"; } s=3D_u5_udl.search; if(s && s!=3D"" && s.indexOf("__utma=3D")>=3D0) { a=3D_u5_uGC(s,"__utma=3D","&"); b=3D_u5_uGC(s,"__utmb=3D","&"); c=3D_u5_uGC(s,"__utmc=3D","&"); if (a!=3D"-" && b!=3D"-" && c!=3D"-") f=3D1; else if(a!=3D"-") f=3D2; } if(f=3D=3D1) { _u5_ubd.cookie=3D"__utma=3D"+a+"; path=3D/;"+nx; _u5_ubd.cookie=3D"__utmb=3D"+b+"; path=3D/;"+x; _u5_ubd.cookie=3D"__utmc=3D"+c+"; path=3D/;"; } else if (f=3D=3D2) { a=3D_u5_uFixA(s,"&",_u5_ust); _u5_ubd.cookie=3D"__utma=3D"+a+"; path=3D/;"+nx; _u5_ubd.cookie=3D"__utmb=3D"+_u5_udh+"; path=3D/;"+x; _u5_ubd.cookie=3D"__utmc=3D"+_u5_udh+"; path=3D/;"; _u5_ufns=3D1; } else if (a>=3D0 && b>=3D0 && c>=3D0) { _u5_ubd.cookie=3D"__utmb=3D"+_u5_udh+"; path=3D/;"+x+_u5_udo; } else { if (a>=3D0) a=3D_u5_uFixA(_u5_ubd.cookie,";",_u5_ust); else a=3D_u5_udh+"."+_u5_uu+"."+_u5_ust+"."+_u5_ust+"."+_u5_ust+".1"; _u5_ubd.cookie=3D"__utma=3D"+a+"; path=3D/;"+nx+_u5_udo; _u5_ubd.cookie=3D"__utmb=3D"+_u5_udh+"; path=3D/;"+x+_u5_udo; _u5_ubd.cookie=3D"__utmc=3D"+_u5_udh+"; path=3D/;"+_u5_udo; _u5_ufns=3D1; } if (s && s!=3D"" && s.indexOf("__utmv=3D")>=3D0) { if ((v=3D_u5_uGC(s,"__utmv=3D","&"))!=3D"-") { _u5_ubd.cookie=3D"__utmv=3D"+unescape(v)+"; path=3D/;"+nx+_u5_udo; } } _u5_uInfo(page); _u5_ufns=3D0; _u5_ufno=3D0; _u5_uff=3D1; } u5_urchinTracker(); function _u5_uInfo(page) { var p,s=3D"",pg=3D_u5_udl.pathname+_u5_udl.search; if (page && page!=3D"") pg=3Descape(page); _u5_ur=3D_u5_ubd.referrer; if (!_u5_ur || _u5_ur=3D=3D"") { _u5_ur=3D"-"; } else { p=3D_u5_ur.indexOf(_u5_ubd.domain); if ((p>=3D0) && (p<=3D8)) { _u5_ur=3D"0"; } if (_u5_ur.indexOf("[")=3D=3D0 && = _u5_ur.lastIndexOf("]")=3D=3D(_u5_ur.length-1)) { _u5_ur=3D"-"; } } s+=3D"&utmn=3D"+_u5_uu; if (_u5_ufsc) s+=3D_u5_uBInfo(page); if (_u5_uctm && (!page || page=3D=3D"")) s+=3D_u5_uCInfo(); if (_u5_utitle && _u5_ubd.title && _u5_ubd.title!=3D"") = s+=3D"&utmdt=3D"+escape(_u5_ubd.title); if (_u5_udl.hostname && _u5_udl.hostname!=3D"") = s+=3D"&utmhn=3D"+escape(_u5_udl.hostname); if (!page || page=3D=3D"") s+=3D"&utmr=3D"+_u5_ur; s+=3D"&utmp=3D"+pg; if (_u5_userv=3D=3D0 || _u5_userv=3D=3D2) { var i=3Dnew Image(1,1); i.src=3D_u5_ugifpath+"?"+"utmwv=3D"+_u5_uwv+s; i.onload=3Dfunction() {_u5_uVoid();} } if (_u5_userv=3D=3D1 || _u5_userv=3D=3D2) { var i2=3Dnew Image(1,1); = i2.src=3D_u5_ugifpath2+"?"+"utmwv=3D"+_u5_uwv+s+"&utmac=3D"+_u5_uacct+"&u= tmcc=3D"+_u5_uGCS(); i2.onload=3Dfunction() { _u5_uVoid(); } } return; } function _u5_uVoid() { return; } function _u5_uCInfo() { if (!_u5_ucto || _u5_ucto=3D=3D"") { _u5_ucto=3D"15768000"; } var c=3D"",t=3D"-",t2=3D"-",o=3D0,cs=3D0,cn=3D0;i=3D0; var s=3D_u5_udl.search; var z=3D_u5_uGC(s,"__utmz=3D","&"); var x=3Dnew Date(_u5_udt.getTime()+(_u5_ucto*1000)); var dc=3D_u5_ubd.cookie; x=3D" expires=3D"+x.toGMTString()+";"; if (z!=3D"-") { _u5_ubd.cookie=3D"__utmz=3D"+unescape(z)+"; = path=3D/;"+x+_u5_udo; return ""; } z=3Ddc.indexOf("__utmz=3D"+_u5_udh); if (z>-1) { z=3D_u5_uGC(dc,"__utmz=3D"+_u5_udh,";"); } else { z=3D"-"; } t=3D_u5_uGC(s,_u5_ucid+"=3D","&"); t2=3D_u5_uGC(s,_u5_ucsr+"=3D","&"); if ((t!=3D"-" && t!=3D"") || (t2!=3D"-" && t2!=3D"")) { if (t!=3D"-" && t!=3D"") { c+=3D"utmcid=3D"+_u5_uEC(t); if (t2!=3D"-" = && t2!=3D"") c+=3D"|utmcsr=3D"+_u5_uEC(t2); } else { if (t2!=3D"-" && t2!=3D"") c+=3D"utmcsr=3D"+_u5_uEC(t2); } t=3D_u5_uGC(s,_u5_uccn+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmccn=3D"+_u5_uEC(t); else c+=3D"|utmccn=3D(not+set)"; t=3D_u5_uGC(s,_u5_ucmd+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmcmd=3D"+_u5_uEC(t); else c+=3D"|utmcmd=3D(not+set)"; t=3D_u5_uGC(s,_u5_uctr+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmctr=3D"+_u5_uEC(t); else { t=3D_u5_uOrg(1); if (t!=3D"-" && t!=3D"") = c+=3D"|utmctr=3D"+_u5_uEC(t); } t=3D_u5_uGC(s,_u5_ucct+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmcct=3D"+_u5_uEC(t); t=3D_u5_uGC(s,_u5_ucno+"=3D","&"); if (t=3D=3D"1") o=3D1; if (z!=3D"-" && o=3D=3D1) return ""; } if (c=3D=3D"-" || c=3D=3D"") { c=3D_u5_uOrg(); if (z!=3D"-" && = _u5_ufno=3D=3D1) return ""; } if (c=3D=3D"-" || c=3D=3D"") { if (_u5_ufns=3D=3D1) c=3D_u5_uRef(); if = (z!=3D"-" && _u5_ufno=3D=3D1) return ""; } if (c=3D=3D"-" || c=3D=3D"") { if (z=3D=3D"-" && _u5_ufns=3D=3D1) { = c=3D"utmccn=3D(direct)|utmcsr=3D(direct)|utmcmd=3D(none)"; } if (c=3D=3D"-" || c=3D=3D"") return ""; } if (z!=3D"-") { i=3Dz.indexOf("."); if (i>-1) i=3Dz.indexOf(".",i+1); if (i>-1) i=3Dz.indexOf(".",i+1); if (i>-1) i=3Dz.indexOf(".",i+1); t=3Dz.substring(i+1,z.length); if (t.toLowerCase()=3D=3Dc.toLowerCase()) cs=3D1; t=3Dz.substring(0,i); if ((i=3Dt.lastIndexOf(".")) > -1) { t=3Dt.substring(i+1,t.length); cn=3D(t*1); } } if (cs=3D=3D0 || _u5_ufns=3D=3D1) { t=3D_u5_uGC(dc,"__utma=3D"+_u5_udh,";"); if ((i=3Dt.lastIndexOf(".")) > 9) { _u5_uns=3Dt.substring(i+1,t.length); _u5_uns=3D(_u5_uns*1); } cn++; if (_u5_uns=3D=3D0) _u5_uns=3D1; = _u5_ubd.cookie=3D"__utmz=3D"+_u5_udh+"."+_u5_ust+"."+_u5_uns+"."+cn+"."+c= +"; path=3D/; "+x+_u5_udo; } if (cs=3D=3D0 || _u5_ufns=3D=3D1) return "&utmcn=3D1"; else return "&utmcr=3D1"; } function _u5_uRef() { if (_u5_ur=3D=3D"0" || _u5_ur=3D=3D"" || _u5_ur=3D=3D"-") return ""; var i=3D0,h,k,n; if ((i=3D_u5_ur.indexOf("://"))<0) return ""; h=3D_u5_ur.substring(i+3,_u5_ur.length); if (h.indexOf("/") > -1) { k=3Dh.substring(h.indexOf("/"),h.length); if (k.indexOf("?") > -1) k=3Dk.substring(0,k.indexOf("?")); h=3Dh.substring(0,h.indexOf("/")); } h=3Dh.toLowerCase(); n=3Dh; if ((i=3Dn.indexOf(":")) > -1) n=3Dn.substring(0,i); for (var ii=3D0;ii<_u5_uRno.length;ii++) { if ((i=3Dn.indexOf(_u5_uRno[ii].toLowerCase())) > -1 && = n.length=3D=3D(i+_u5_uRno[ii].length)) { _u5_ufno=3D1; break; } } if (h.indexOf("www.")=3D=3D0) h=3Dh.substring(4,h.length); return = "utmccn=3D(referral)|utmcsr=3D"+_u5_uEC(h)+"|"+"utmcct=3D"+_u5_uEC(k)+"|u= tmcmd=3Dreferral"; } function _u5_uOrg(t) { if (_u5_ur=3D=3D"0" || _u5_ur=3D=3D"" || _u5_ur=3D=3D"-") return ""; var i=3D0,h,k; if ((i=3D_u5_ur.indexOf("://")) < 0) return ""; h=3D_u5_ur.substring(i+3,_u5_ur.length); if (h.indexOf("/") > -1) { h=3Dh.substring(0,h.indexOf("/")); } for (var ii=3D0;ii<_u5_uOsr.length;ii++) { if (h.indexOf(_u5_uOsr[ii]) > -1) { if ((i=3D_u5_ur.indexOf("?"+_u5_uOkw[ii]+"=3D")) > -1 || = (i=3D_u5_ur.indexOf("&"+_u5_uOkw[ii]+"=3D")) > -1) { k=3D_u5_ur.substring(i+_u5_uOkw[ii].length+2,_u5_ur.length); if ((i=3Dk.indexOf("&")) > -1) k=3Dk.substring(0,i); for (var yy=3D0;yy<_u5_uOno.length;yy++) { if (_u5_uOno[yy].toLowerCase()=3D=3Dk.toLowerCase()) { = _u5_ufno=3D1; break; } } if (t) return _u5_uEC(k); else return = "utmccn=3D(organic)|utmcsr=3D"+_u5_uEC(_u5_uOsr[ii])+"|"+"utmctr=3D"+_u5_= uEC(k)+"|utmcmd=3Dorganic"; } } } return ""; } function _u5_uBInfo(page) { var sr=3D"-",sc=3D"-",ul=3D"-",fl=3D"-",je=3D1; var n=3Dnavigator; if (self.screen) { sr=3Dscreen.width+"x"+screen.height; sc=3Dscreen.colorDepth+"-bit"; } else if (self.java) { var j=3Djava.awt.Toolkit.getDefaultToolkit(); var s=3Dj.getScreenSize(); sr=3Ds.width+"x"+s.height; } if (_u5_ujv=3D=3D"-" && (!page || page=3D=3D"")) { for (var i=3D5;i>=3D0;i--) { var t=3D""; _u5_ubd.write(t); if (_u5_ujv!=3D"-") break; } } if (n.language) { ul=3Dn.language.toLowerCase(); } else if (n.browserLanguage) { ul=3Dn.browserLanguage.toLowerCase(); } je=3Dn.javaEnabled()?1:0; if (_u5_uflash) fl=3D_u5_uFlash(); return = "&utmsr=3D"+sr+"&utmsc=3D"+sc+"&utmul=3D"+ul+"&utmje=3D"+je+"&utmjv=3D"+_= u5_ujv+"&utmfl=3D"+fl; } function _u5__utmSetTrans() { var e; if (_u5_ubd.getElementById) e=3D_u5_ubd.getElementById("utmtrans"); else if (_u5_ubd.utmform && _u5_ubd.utmform.utmtrans) = e=3D_u5_ubd.utmform.utmtrans; if (!e) return; var l=3De.value.split("UTM:"); var i,i2,c; if (_u5_userv=3D=3D0 || _u5_userv=3D=3D2) i=3Dnew Array(); if (_u5_userv=3D=3D1 || _u5_userv=3D=3D2) { i2=3Dnew Array(); = c=3D_u5_uGCS(); } for (var ii=3D0;ii=3D2;ii--) { try { var fl=3Deval("new = ActiveXObject('ShockwaveFlash.ShockwaveFlash."+ii+"');"); if (fl) { f=3Dii + '.0'; break; } } catch(e) {} } } return f; } function _u5__utmLinker(l) { var p,a=3D"-",b=3D"-",c=3D"-",z=3D"-",v=3D"-"; var dc=3D_u5_ubd.cookie; if (l && l!=3D"") { if (dc) { a=3D_u5_uGC(dc,"__utma=3D"+_u5_udh,";"); b=3D_u5_uGC(dc,"__utmb=3D"+_u5_udh,";"); c=3D_u5_uGC(dc,"__utmc=3D"+_u5_udh,";"); z=3D_u5_uGC(dc,"__utmz=3D"+_u5_udh,";"); v=3D_u5_uGC(dc,"__utmv=3D"+_u5_udh,";"); = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmz=3D"+escape(z)+"&= __utmv=3D"+escape(v); } if (p) { if (l.indexOf("?")<=3D-1) { document.location=3Dl+"?"+p; } else { document.location=3Dl+"&"+p; } } else { document.location=3Dl; } } } function _u5__utmLinkPost(f) { var p,a=3D"-",b=3D"-",c=3D"-",z=3D"-",v=3D"-"; var dc=3D_u5_ubd.cookie; if (!f || !f.action) return; if (dc) { a=3D_u5_uGC(dc,"__utma=3D"+_u5_udh,";"); b=3D_u5_uGC(dc,"__utmb=3D"+_u5_udh,";"); c=3D_u5_uGC(dc,"__utmc=3D"+_u5_udh,";"); z=3D_u5_uGC(dc,"__utmz=3D"+_u5_udh,";"); v=3D_u5_uGC(dc,"__utmv=3D"+_u5_udh,";"); = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmz=3D"+escape(z)+"&= __utmv=3D"+escape(v); } if (p) { if (f.action.indexOf("?")<=3D-1) f.action+=3D"?"+p; else f.action+=3D"&"+p; } return; } function _u5__utmSetVar(v) { if (!v || v=3D=3D"") return; var r=3DMath.round(Math.random() * 2147483647); _u5_ubd.cookie=3D"__utmv=3D"+_u5_udh+"."+escape(v)+"; path=3D/; = expires=3DSun, 18 Jan 2038 00:00:00 GMT;"+_u5_udo; var s=3D"&utmt=3Dvar&utmn=3D"+r; if (_u5_userv=3D=3D0 || _u5_userv=3D=3D2) { var i=3Dnew Image(1,1); i.src=3D_u5_ugifpath+"?"+"utmwv=3D"+_u5_uwv+s; i.onload=3Dfunction() { _u5_uVoid(); } } if (_u5_userv=3D=3D1 || _u5_userv=3D=3D2) { var i2=3Dnew Image(1,1); = i2.src=3D_u5_ugifpath2+"?"+"utmwv=3D"+_u5_uwv+s+"&utmac=3D"+_u5_uacct+"&u= tmcc=3D"+_u5_uGCS(); 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