From: Subject: =?Windows-1252?Q?AIDS-related_primary_central_nervous_system_lymphoma:_a_?= =?Windows-1252?Q?Norwegian_national_survey_1989=962003?= Date: Sat, 29 Nov 2008 16:33:49 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_002D_01C95240.41ED11D0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_002D_01C95240.41ED11D0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2525658&rendertype=abstract =EF=BB=BF AIDS-related primary central nervous system lymphoma: = a Norwegian national survey 1989=E2=80=932003 = <= LINK=20 rel=3Dstylesheet type=3Dtext/css=20 href=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbars-slatebl= ue.css"><= LINK=20 rel=3Dstylesheet type=3Dtext/css=20 href=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcrefs3.css"> =
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PubMed articles by:
Haldorsen,=20 I.
Kr=C3=A5kenes,=20 J.
Goplen,=20 A.
Espeland,=20 A.
BMC Cancer. = 2008; 8: 225.=20
Published online 2008 = August 6.=20 doi:=20 10.1186/1471-2407-8-225.
PMCID:=20 PMC2525658
Copyright<= /A>=20 =C2=A9 2008 Haldorsen et al; licensee BioMed Central Ltd.
AIDS-related primary central nervous system = lymphoma:=20 a Norwegian national survey 1989=E2=80=932003
Ingfrid S = Haldorsen,1,2=20 Jostein Kr=C3=A5kenes,1,2 Anne K = Goplen,3 Oona=20 Dunlop,4 Olav Mella,5,6 and = Ansgar=20 Espeland1,2
1Department of Radiology, = Haukeland=20 University Hospital, Bergen, Norway
2Section for Radiology, Department = of=20 Surgical Sciences, University of Bergen, Bergen, Norway
3Department of Pathology, Ullevaal = University Hospital, Oslo, Norway
4Department of Infectious Diseases = and=20 Department of Acute Medicine, Ullevaal University Hospital, Oslo,=20 Norway
5Department of Oncology and = Medical Physics,=20 Haukeland University Hospital, Bergen, Norway
6Section of Oncology, Institute of = Medicine,=20 University of Bergen, Bergen, Norway
3D"correspondingCorresponding=20 author.
Ingfrid S Haldorsen: ingfrid.haldorsen/at/helse-bergen.no ; Jostein = Kr=C3=A5kenes:=20 jostein.krakenes/at/helse-bergen.no ; Anne K = Goplen: ango/at/uus.no ; Oona = Dunlop: ondu/at/uus.no ; Olav = Mella: olav.mella/at/helse-bergen.no ; Ansgar = Espeland:=20 ansgar.espeland/at/helse-bergen.no
Received March 12, 2008; Accepted August = 6,=20 2008.

This is an Open Access article distributed under the terms of = the=20 Creative Commons Attribution License (http://www.pubmedcentral.nih.gov/redire= ct3.cgi?&&auth=3D0xcAutasseEV2E47rvLluJMNKE891nAO7JEFRk5z1&re= ftype=3Dextlink&artid=3D2525658&article-id=3D2525658&iid=3D16= 1262&issue-id=3D161262&jid=3D16&journal-id=3D16&FROM=3DAr= ticle%7CFront%20Matter&TO=3DExternal%7CLink%7CURI&rendering-type=3D= normal&&http://creativecommons.org/licenses/by/2.0),=20 which permits unrestricted use, distribution, and reproduction in = any=20 medium, provided the original work is properly=20 cited.

 
Abstract

Background
Primary = central=20 nervous system lymphoma (PCNSL) is a frequent complication in = acquired=20 immunodeficiency syndrome (AIDS). The objective of this survey was = to=20 investigate incidence, clinical features, radiological findings,=20 histologic diagnosis, treatment and outcome for all patients with=20 histologically verified AIDS-related PCNSL diagnosed in Norway in=20 1989=E2=80=932003.

Methods
We identified = the=20 patients by chart review of all cases recorded as PCNSL in The = Norwegian=20 Cancer Registry (by law recording all cases of cancer in Norway) = and all=20 cases recorded as AIDS-related PCNSL in the autopsy registry at a = hospital=20 having 67% autopsy rate and treating 59% of AIDS patients in = Norway, from=20 1989 to 2003. Histologic material and radiological images were = reviewed.=20 We used person-time techniques to calculate incidence rates of = PCNSL among=20 AIDS patients based on recordings on AIDS at the Norwegian = Surveillance=20 System for Communicable Diseases (by law recording all cases of = AIDS in=20 Norway).

Results
Twenty-nine = patients had=20 histologically confirmed, newly diagnosed AIDS-related PCNSL in = Norway=20 from 1989=E2=80=932003. Only 2 patients had this diagnosis = established while=20 alive. AIDS patients had 5.5% lifetime risk of PCNSL. Their = absolute=20 incidence rate of PCNSL per 100 person-years was 1.7 (95%CI: = 1.1=E2=80=932.4) and=20 decreased during the consecutive 5-year periods from 3.6, to 2.5, = and to=20 0.4 (p < 0.001). Median survival from initial symptom of PCNSL = was 2.3=20 months, but one patient was still alive 4 years after completed=20 radiotherapy.

Conclusion
This is the = first=20 national survey to confirm decreasing incidence of AIDS-related = PCNSL.=20 Despite dismal survival in most patients, the possibility of long = term=20 survival should prompt more aggressive diagnostics in suspected = PCNSL.

Articles=20 from BMC Cancer = are=20 provided here courtesy of
BioMed Central
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