From: Subject: BioMed Central | Abstract | 1471-2202-9-15 | Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma Date: Sun, 3 Feb 2008 19:00:26 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0004_01C86697.09566190" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0004_01C86697.09566190 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.biomedcentral.com/1471-2202/9/15 =EF=BB=BF BioMed Central | = Abstract | 1471-2202-9-15 | Potential identity of multi-potential cancer = stem-like subpopulation after radiation of cultured brain glioma

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Research article

Potential identity of multi-potential cancer stem-like = subpopulation=20 after radiation of cultured brain glioma

Mi K Kang ,=20 Beong I Her ,=20 Mi H Ko ,=20 Cheul H Kim ,=20 Seung H Cha and = Soo K Kang

BMC Neuroscience 2008,=20 9:15doi:10.1186/1471-2202-9-15


Published:	30 January 2008

Abstract (provisional)

Background

Glioblastoma multiforme (GBM) is the most frequently = encountered brain=20 cancer. Although the existence of cancer stem cells in GBM has = been=20 previously established, there is little evidence to explain the = difference=20 between cancer stem cells and radio-resistant cells in GBM. In an = effort=20 to increase our understanding of whether cellular radio-resistance = is a=20 characteristic associated with cancer stem cells, we developed a=20 dissociated cell system of subpopulations derived from GBM, and=20 demonstrated radiotherapy resistance therein.

Results

The radio-resistant cancer cell subpopulations of GBM = abundantly=20 express CD133, CD117, CD71, and CD45 surface markers, and these=20 radio-resistant cancer cell subpopulations have the capacity for = extensive=20 proliferation, self-renewal, and pluripotency. These = radio-resistant=20 cancer subpopulations have been shown to initiate tumorigenesis = when=20 transplanted into SCID mouse brains. Moreover, these tumors = evidenced=20 highly peculiar nest-like shapes harboring both vascular and = cancerous=20 tissue structures, which expressed the blood vessel specific = marker, the=20 von Willebrand factor. Accordingly, subpopulations of = radio-resistant=20 cells in GBM have been shown to be very similar to hematopoietic = stem=20 cells (HSCs) in the circulating blood. This similarity may = contribute to=20 increased tumor growth and GBM recurrence.

Conclusion

The results of the present study provide further evidence for = radio=20 resistant subpopulations of cancer stem cells in GBM . Also, our = results=20 will assist in the identification and characterization of cancer = stem cell=20 populations in glioma, and will help to improve the therapeutic = outcomes=20 of GBM.

The complete article is available as a = prov= isional=20 PDF. The fully formatted PDF and HTML versions are in = production.=20

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=C2=A9 1999-2008 BioMed Central Ltd = unless otherwise=20 stated

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Date(_u5_udt.getTime()+(_u5_utimeout*1000)); x=3D" expires=3D"+x.toGMTString()+";"; } s=3D_u5_udl.search; if(s && s!=3D"" && s.indexOf("__utma=3D")>=3D0) { a=3D_u5_uGC(s,"__utma=3D","&"); b=3D_u5_uGC(s,"__utmb=3D","&"); c=3D_u5_uGC(s,"__utmc=3D","&"); if (a!=3D"-" && b!=3D"-" && c!=3D"-") f=3D1; else if(a!=3D"-") f=3D2; } if(f=3D=3D1) { _u5_ubd.cookie=3D"__utma=3D"+a+"; path=3D/;"+nx; _u5_ubd.cookie=3D"__utmb=3D"+b+"; path=3D/;"+x; _u5_ubd.cookie=3D"__utmc=3D"+c+"; path=3D/;"; } else if (f=3D=3D2) { a=3D_u5_uFixA(s,"&",_u5_ust); _u5_ubd.cookie=3D"__utma=3D"+a+"; path=3D/;"+nx; _u5_ubd.cookie=3D"__utmb=3D"+_u5_udh+"; path=3D/;"+x; _u5_ubd.cookie=3D"__utmc=3D"+_u5_udh+"; path=3D/;"; _u5_ufns=3D1; } else if (a>=3D0 && b>=3D0 && c>=3D0) { _u5_ubd.cookie=3D"__utmb=3D"+_u5_udh+"; path=3D/;"+x+_u5_udo; } else { if (a>=3D0) a=3D_u5_uFixA(_u5_ubd.cookie,";",_u5_ust); else a=3D_u5_udh+"."+_u5_uu+"."+_u5_ust+"."+_u5_ust+"."+_u5_ust+".1"; _u5_ubd.cookie=3D"__utma=3D"+a+"; path=3D/;"+nx+_u5_udo; _u5_ubd.cookie=3D"__utmb=3D"+_u5_udh+"; path=3D/;"+x+_u5_udo; _u5_ubd.cookie=3D"__utmc=3D"+_u5_udh+"; path=3D/;"+_u5_udo; _u5_ufns=3D1; } if (s && s!=3D"" && s.indexOf("__utmv=3D")>=3D0) { if ((v=3D_u5_uGC(s,"__utmv=3D","&"))!=3D"-") { _u5_ubd.cookie=3D"__utmv=3D"+unescape(v)+"; path=3D/;"+nx+_u5_udo; } } _u5_uInfo(page); _u5_ufns=3D0; _u5_ufno=3D0; _u5_uff=3D1; } u5_urchinTracker(); function _u5_uInfo(page) { var p,s=3D"",pg=3D_u5_udl.pathname+_u5_udl.search; if (page && page!=3D"") pg=3Descape(page); _u5_ur=3D_u5_ubd.referrer; if (!_u5_ur || _u5_ur=3D=3D"") { _u5_ur=3D"-"; } else { p=3D_u5_ur.indexOf(_u5_ubd.domain); if ((p>=3D0) && (p<=3D8)) { _u5_ur=3D"0"; } if (_u5_ur.indexOf("[")=3D=3D0 && = _u5_ur.lastIndexOf("]")=3D=3D(_u5_ur.length-1)) { _u5_ur=3D"-"; } } s+=3D"&utmn=3D"+_u5_uu; if (_u5_ufsc) s+=3D_u5_uBInfo(page); if (_u5_uctm && (!page || page=3D=3D"")) s+=3D_u5_uCInfo(); if (_u5_utitle && _u5_ubd.title && _u5_ubd.title!=3D"") = s+=3D"&utmdt=3D"+escape(_u5_ubd.title); if (_u5_udl.hostname && _u5_udl.hostname!=3D"") = s+=3D"&utmhn=3D"+escape(_u5_udl.hostname); if (!page || page=3D=3D"") s+=3D"&utmr=3D"+_u5_ur; s+=3D"&utmp=3D"+pg; if (_u5_userv=3D=3D0 || _u5_userv=3D=3D2) { var i=3Dnew Image(1,1); i.src=3D_u5_ugifpath+"?"+"utmwv=3D"+_u5_uwv+s; i.onload=3Dfunction() {_u5_uVoid();} } if (_u5_userv=3D=3D1 || _u5_userv=3D=3D2) { var i2=3Dnew Image(1,1); = i2.src=3D_u5_ugifpath2+"?"+"utmwv=3D"+_u5_uwv+s+"&utmac=3D"+_u5_uacct+"&u= tmcc=3D"+_u5_uGCS(); i2.onload=3Dfunction() { _u5_uVoid(); } } return; } function _u5_uVoid() { return; } function _u5_uCInfo() { if (!_u5_ucto || _u5_ucto=3D=3D"") { _u5_ucto=3D"15768000"; } var c=3D"",t=3D"-",t2=3D"-",o=3D0,cs=3D0,cn=3D0;i=3D0; var s=3D_u5_udl.search; var z=3D_u5_uGC(s,"__utmz=3D","&"); var x=3Dnew Date(_u5_udt.getTime()+(_u5_ucto*1000)); var dc=3D_u5_ubd.cookie; x=3D" expires=3D"+x.toGMTString()+";"; if (z!=3D"-") { _u5_ubd.cookie=3D"__utmz=3D"+unescape(z)+"; = path=3D/;"+x+_u5_udo; return ""; } z=3Ddc.indexOf("__utmz=3D"+_u5_udh); if (z>-1) { z=3D_u5_uGC(dc,"__utmz=3D"+_u5_udh,";"); } else { z=3D"-"; } t=3D_u5_uGC(s,_u5_ucid+"=3D","&"); t2=3D_u5_uGC(s,_u5_ucsr+"=3D","&"); if ((t!=3D"-" && t!=3D"") || (t2!=3D"-" && t2!=3D"")) { if (t!=3D"-" && t!=3D"") { c+=3D"utmcid=3D"+_u5_uEC(t); if (t2!=3D"-" = && t2!=3D"") c+=3D"|utmcsr=3D"+_u5_uEC(t2); } else { if (t2!=3D"-" && t2!=3D"") c+=3D"utmcsr=3D"+_u5_uEC(t2); } t=3D_u5_uGC(s,_u5_uccn+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmccn=3D"+_u5_uEC(t); else c+=3D"|utmccn=3D(not+set)"; t=3D_u5_uGC(s,_u5_ucmd+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmcmd=3D"+_u5_uEC(t); else c+=3D"|utmcmd=3D(not+set)"; t=3D_u5_uGC(s,_u5_uctr+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmctr=3D"+_u5_uEC(t); else { t=3D_u5_uOrg(1); if (t!=3D"-" && t!=3D"") = c+=3D"|utmctr=3D"+_u5_uEC(t); } t=3D_u5_uGC(s,_u5_ucct+"=3D","&"); if (t!=3D"-" && t!=3D"") c+=3D"|utmcct=3D"+_u5_uEC(t); t=3D_u5_uGC(s,_u5_ucno+"=3D","&"); if (t=3D=3D"1") o=3D1; if (z!=3D"-" && o=3D=3D1) return ""; } if (c=3D=3D"-" || c=3D=3D"") { c=3D_u5_uOrg(); if (z!=3D"-" && = _u5_ufno=3D=3D1) return ""; } if (c=3D=3D"-" || c=3D=3D"") { if (_u5_ufns=3D=3D1) c=3D_u5_uRef(); if = (z!=3D"-" && _u5_ufno=3D=3D1) return ""; } if (c=3D=3D"-" || c=3D=3D"") { if (z=3D=3D"-" && _u5_ufns=3D=3D1) { = c=3D"utmccn=3D(direct)|utmcsr=3D(direct)|utmcmd=3D(none)"; } if (c=3D=3D"-" || c=3D=3D"") return ""; } if (z!=3D"-") { i=3Dz.indexOf("."); if (i>-1) i=3Dz.indexOf(".",i+1); if (i>-1) i=3Dz.indexOf(".",i+1); if (i>-1) i=3Dz.indexOf(".",i+1); t=3Dz.substring(i+1,z.length); if (t.toLowerCase()=3D=3Dc.toLowerCase()) cs=3D1; t=3Dz.substring(0,i); if ((i=3Dt.lastIndexOf(".")) > -1) { t=3Dt.substring(i+1,t.length); cn=3D(t*1); } } if (cs=3D=3D0 || _u5_ufns=3D=3D1) { t=3D_u5_uGC(dc,"__utma=3D"+_u5_udh,";"); if ((i=3Dt.lastIndexOf(".")) > 9) { _u5_uns=3Dt.substring(i+1,t.length); _u5_uns=3D(_u5_uns*1); } cn++; if (_u5_uns=3D=3D0) _u5_uns=3D1; = _u5_ubd.cookie=3D"__utmz=3D"+_u5_udh+"."+_u5_ust+"."+_u5_uns+"."+cn+"."+c= +"; path=3D/; "+x+_u5_udo; } if (cs=3D=3D0 || _u5_ufns=3D=3D1) return "&utmcn=3D1"; else return "&utmcr=3D1"; } function _u5_uRef() { if (_u5_ur=3D=3D"0" || _u5_ur=3D=3D"" || _u5_ur=3D=3D"-") return ""; var i=3D0,h,k,n; if ((i=3D_u5_ur.indexOf("://"))<0) return ""; h=3D_u5_ur.substring(i+3,_u5_ur.length); if (h.indexOf("/") > -1) { k=3Dh.substring(h.indexOf("/"),h.length); if (k.indexOf("?") > -1) k=3Dk.substring(0,k.indexOf("?")); h=3Dh.substring(0,h.indexOf("/")); } h=3Dh.toLowerCase(); n=3Dh; if ((i=3Dn.indexOf(":")) > -1) n=3Dn.substring(0,i); for (var ii=3D0;ii<_u5_uRno.length;ii++) { if ((i=3Dn.indexOf(_u5_uRno[ii].toLowerCase())) > -1 && = n.length=3D=3D(i+_u5_uRno[ii].length)) { _u5_ufno=3D1; break; } } if (h.indexOf("www.")=3D=3D0) h=3Dh.substring(4,h.length); return = "utmccn=3D(referral)|utmcsr=3D"+_u5_uEC(h)+"|"+"utmcct=3D"+_u5_uEC(k)+"|u= tmcmd=3Dreferral"; } function _u5_uOrg(t) { if (_u5_ur=3D=3D"0" || _u5_ur=3D=3D"" || _u5_ur=3D=3D"-") return ""; var i=3D0,h,k; if ((i=3D_u5_ur.indexOf("://")) < 0) return ""; h=3D_u5_ur.substring(i+3,_u5_ur.length); if (h.indexOf("/") > -1) { h=3Dh.substring(0,h.indexOf("/")); } for (var ii=3D0;ii<_u5_uOsr.length;ii++) { if (h.indexOf(_u5_uOsr[ii]) > -1) { if ((i=3D_u5_ur.indexOf("?"+_u5_uOkw[ii]+"=3D")) > -1 || = (i=3D_u5_ur.indexOf("&"+_u5_uOkw[ii]+"=3D")) > -1) { k=3D_u5_ur.substring(i+_u5_uOkw[ii].length+2,_u5_ur.length); if ((i=3Dk.indexOf("&")) > -1) k=3Dk.substring(0,i); for (var yy=3D0;yy<_u5_uOno.length;yy++) { if (_u5_uOno[yy].toLowerCase()=3D=3Dk.toLowerCase()) { = _u5_ufno=3D1; break; } } if (t) return _u5_uEC(k); else return = "utmccn=3D(organic)|utmcsr=3D"+_u5_uEC(_u5_uOsr[ii])+"|"+"utmctr=3D"+_u5_= uEC(k)+"|utmcmd=3Dorganic"; } } } return ""; } function _u5_uBInfo(page) { var sr=3D"-",sc=3D"-",ul=3D"-",fl=3D"-",je=3D1; var n=3Dnavigator; if (self.screen) { sr=3Dscreen.width+"x"+screen.height; sc=3Dscreen.colorDepth+"-bit"; } else if (self.java) { var j=3Djava.awt.Toolkit.getDefaultToolkit(); var s=3Dj.getScreenSize(); sr=3Ds.width+"x"+s.height; } if (_u5_ujv=3D=3D"-" && (!page || page=3D=3D"")) { for (var i=3D5;i>=3D0;i--) { var t=3D""; _u5_ubd.write(t); if (_u5_ujv!=3D"-") break; } } if (n.language) { ul=3Dn.language.toLowerCase(); } else if (n.browserLanguage) { ul=3Dn.browserLanguage.toLowerCase(); } je=3Dn.javaEnabled()?1:0; if (_u5_uflash) fl=3D_u5_uFlash(); return = "&utmsr=3D"+sr+"&utmsc=3D"+sc+"&utmul=3D"+ul+"&utmje=3D"+je+"&utmjv=3D"+_= u5_ujv+"&utmfl=3D"+fl; } function _u5__utmSetTrans() { var e; if (_u5_ubd.getElementById) e=3D_u5_ubd.getElementById("utmtrans"); else if (_u5_ubd.utmform && _u5_ubd.utmform.utmtrans) = e=3D_u5_ubd.utmform.utmtrans; if (!e) return; var l=3De.value.split("UTM:"); var i,i2,c; if (_u5_userv=3D=3D0 || _u5_userv=3D=3D2) i=3Dnew Array(); if (_u5_userv=3D=3D1 || _u5_userv=3D=3D2) { i2=3Dnew Array(); = c=3D_u5_uGCS(); } for (var ii=3D0;ii=3D2;ii--) { try { var fl=3Deval("new = ActiveXObject('ShockwaveFlash.ShockwaveFlash."+ii+"');"); if (fl) { f=3Dii + '.0'; break; } } catch(e) {} } } return f; } function _u5__utmLinker(l) { var p,a=3D"-",b=3D"-",c=3D"-",z=3D"-",v=3D"-"; var dc=3D_u5_ubd.cookie; if (l && l!=3D"") { if (dc) { a=3D_u5_uGC(dc,"__utma=3D"+_u5_udh,";"); b=3D_u5_uGC(dc,"__utmb=3D"+_u5_udh,";"); c=3D_u5_uGC(dc,"__utmc=3D"+_u5_udh,";"); z=3D_u5_uGC(dc,"__utmz=3D"+_u5_udh,";"); v=3D_u5_uGC(dc,"__utmv=3D"+_u5_udh,";"); = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmz=3D"+escape(z)+"&= __utmv=3D"+escape(v); } if (p) { if (l.indexOf("?")<=3D-1) { document.location=3Dl+"?"+p; } else { document.location=3Dl+"&"+p; } } else { document.location=3Dl; } } } function _u5__utmLinkPost(f) { var p,a=3D"-",b=3D"-",c=3D"-",z=3D"-",v=3D"-"; var dc=3D_u5_ubd.cookie; if (!f || !f.action) return; if (dc) { a=3D_u5_uGC(dc,"__utma=3D"+_u5_udh,";"); b=3D_u5_uGC(dc,"__utmb=3D"+_u5_udh,";"); c=3D_u5_uGC(dc,"__utmc=3D"+_u5_udh,";"); z=3D_u5_uGC(dc,"__utmz=3D"+_u5_udh,";"); v=3D_u5_uGC(dc,"__utmv=3D"+_u5_udh,";"); = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmz=3D"+escape(z)+"&= __utmv=3D"+escape(v); } if (p) { if (f.action.indexOf("?")<=3D-1) f.action+=3D"?"+p; else f.action+=3D"&"+p; } return; } function _u5__utmSetVar(v) { if (!v || v=3D=3D"") return; var r=3DMath.round(Math.random() * 2147483647); _u5_ubd.cookie=3D"__utmv=3D"+_u5_udh+"."+escape(v)+"; path=3D/; = expires=3DSun, 18 Jan 2038 00:00:00 GMT;"+_u5_udo; var s=3D"&utmt=3Dvar&utmn=3D"+r; if (_u5_userv=3D=3D0 || _u5_userv=3D=3D2) { var i=3Dnew Image(1,1); i.src=3D_u5_ugifpath+"?"+"utmwv=3D"+_u5_uwv+s; i.onload=3Dfunction() { _u5_uVoid(); } } if (_u5_userv=3D=3D1 || _u5_userv=3D=3D2) { var i2=3Dnew Image(1,1); = i2.src=3D_u5_ugifpath2+"?"+"utmwv=3D"+_u5_uwv+s+"&utmac=3D"+_u5_uacct+"&u= tmcc=3D"+_u5_uGCS(); i2.onload=3Dfunction() { _u5_uVoid(); } } } function _u5_uGCS() { var t,c=3D"",dc=3D_u5_ubd.cookie; 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d=3Dd.substring(4,d.length); } _u5_udn=3Dd; } if (_u5_uhash=3D=3D"off") return 1; return _u5_uHash(_u5_udn); } function _u5_uHash(d) { if (!d || d=3D=3D"") return 1; var h=3D0,g=3D0; for (var i=3Dd.length-1;i>=3D0;i--) { var c=3DparseInt(d.charCodeAt(i)); h=3D((h << 6) & 0xfffffff) + c + (c << 14); if ((g=3Dh & 0xfe00000)!=3D0) h=3D(h ^ (g >> 21)); } return h; } function _u5_uFixA(c,s,t) { if (!c || c=3D=3D"" || !s || s=3D=3D"" || !t || t=3D=3D"") return "-"; var a=3D_u5_uGC(c,"__utma=3D"+_u5_udh,s); var lt=3D0,i=3D0; if ((i=3Da.lastIndexOf(".")) > 9) { _u5_uns=3Da.substring(i+1,a.length); _u5_uns=3D(_u5_uns*1)+1; a=3Da.substring(0,i); if ((i=3Da.lastIndexOf(".")) > 7) { lt=3Da.substring(i+1,a.length); a=3Da.substring(0,i); } if ((i=3Da.lastIndexOf(".")) > 5) { a=3Da.substring(0,i); } a+=3D"."+lt+"."+t+"."+_u5_uns; } return a; } function _u5_uTrim(s) { if (!s || s=3D=3D"") return ""; while ((s.charAt(0)=3D=3D' ') || (s.charAt(0)=3D=3D'\n') || = (s.charAt(0,1)=3D=3D'\r')) 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window.open(url,n,'width=3D'+w+',height=3D'+h+',resizable=3Dyes,scrollbar= s=3Dyes,toolbar=3Dno,location=3Dno,directories=3Dno,status=3Dno,menubar=3D= no,copyhistory=3Dno'); } function fullpopup(url,n,w,h) { = window.open(url,n,'width=3D'+w+',height=3D'+h+',resizable=3Dyes,scrollbar= s=3Dyes,toolbar=3Dyes,location=3Dyes,directories=3Dyes,status=3Dyes,menub= ar=3Dyes,copyhistory=3Dyes'); } function largepopup(url,n,w,h)=20 { var wi=3D520, he=3D550; if (undefined !=3D w) wi=3Dw; if (undefined !=3D h) he=3Dh; if (window.screen) { if (undefined =3D=3D w) wi =3D screen.availWidth-100; if (undefined =3D=3D h) he =3D screen.availHeight-200; } = window.open(url,n,'width=3D'+wi+',height=3D'+he+',top=3D10,left=3D10,resi= zable=3Dyes,scrollbars=3Dyes,toolbar=3Dyes,location=3Dyes,directories=3Dy= es,status=3Dyes,menubar=3Dyes,copyhistory=3Dyes'); } function loadhalf(width) { var popwidth =3D typeof width !=3D 'undefined'? width+40 : 640; if (popwidth > screen.availWidth) popwidth =3D screen.availWidth; if (popwidth < 640) popwidth =3D 640; window.focus(); window.moveTo(0,0); window.resizeTo(popwidth,screen.availHeight); window.blur; } function loadfull()=20 { window.focus(); window.moveTo(0,0); window.resizeTo(screen.availWidth,screen.availHeight); window.blur; } function loadInParent(link)=20 { if (parent.window.opener.closed) window.open(link); else { parent.window.opener.location =3D link; parent.window.focus(); } } function toggleauthors(auth,button) { try{ var aut=3D document.getElementById(auth); var but =3D document.getElementById(button); if (aut.style.display !=3D "none") { aut.style.display =3D "none"; but.src =3D "/bmcimages/expand2.gif"; } else { aut.style.display =3D "block"; but.src =3D "/bmcimages/contract2.gif"; } } catch(e){} } function andtotext() { document.write(" | Return to text") } function stepback(text) { document.write("" + text + "") } function turn() { if (window.location.hash.length > 0) window.history.back();=20 else window.location=3D"#"; } function goback() { window.history.back();=20 } // Movie embedding. Part 1 - Player detection (incl. version detection), = courtesy of http://skyzyx.com/ // QuickTime detection var quicktime=3Dnew Object(); // Set some base values quicktime.installed=3Dfalse; quicktime.version=3D'0.0'; // for non-IE browsers if (navigator.plugins && navigator.plugins.length) { for (x=3D0; x=3D 0.0; movietext=3D"

"; break; case "mp4": cond =3D document.getElementById && quicktime.version >=3D 6.0; movietext=3D"

"; break; case "peg": ; case "mpg": cond =3D document.getElementById && quicktime.version >=3D 6.4; movietext=3D"

"; break; case "avi": cond =3D document.getElementById && quicktime.version >=3D 3.0; movietext=3D"

"; break; case "mov": cond =3D document.getElementById && quicktime.version >=3D 3.0 ; movietext=3D"

"; break; } =09 // This executes the replacement if (cond) { document.getElementById(id).innerHTML=3Dmovietext; link =3D false; } } //Functions related to FLV movies // Stopping the movie when another is started var currentItem; function getUpdate(typ,pr1,pr2,pid) { if (typ =3D=3D "state") { =09 // Play=20 if (pr1 =3D=3D 2) { =09 // Pause active movie if it is playing. if (currentItem !=3D null && currentItem !=3D pid) { thisMovie(currentItem).sendEvent('playpause'); } =09 // Save current movie currentItem =3D pid;=09 =09 // Flush active movie var on Stop (3) and Pause (0). } else if(pr1 =3D=3D 3 || pr1 =3D=3D 0) { = =20 currentItem =3D null; }=20 } }; // This is a javascript handler for the player and is always needed. function thisMovie(movieName) { if(navigator.appName.indexOf("Microsoft") !=3D -1) { return window[movieName]; } else { return document[movieName]; } }; // Replacing the jpeg with the movie var link =3D true; function playvideo(id,moviename,width,height) { if (document.getElementById) { var flvheight =3D height + 20; var so =3D new = SWFObject('/movies/mediaplayer.swf','js'+id,width,flvheight,'7'); =20 so.useExpressInstall('/movies/expressinstall.swf');=20 so.addParam('allowfullscreen','true'); so.addParam('salign','lt'); so.addParam('quality','high'); so.addParam('scale','noscale'); so.addVariable('file',moviename); =20 so.addVariable('autostart','true'); so.addVariable('showdigits','false'); so.addVariable('useaudio','false'); so.addVariable('usefullscreen','true'); so.addVariable('showicons','false'); so.addVariable('enablejs','true'); so.addVariable('javascriptid','js'+id); = =20 so.addVariable('width',width); so.addVariable('height',flvheight); so.write(id); link =3D false; } } /** * SWFObject v1.5: Flash Player detection and embed - = http://blog.deconcept.com/swfobject/ * * SWFObject is (c) 2007 Geoff Stearns and is released under the MIT = License: * http://www.opensource.org/licenses/mit-license.php * */ if(typeof deconcept=3D=3D"undefined"){var deconcept=3Dnew = Object();}if(typeof = deconcept.util=3D=3D"undefined"){deconcept.util=3Dnew = Object();}if(typeof = deconcept.SWFObjectUtil=3D=3D"undefined"){deconcept.SWFObjectUtil=3Dnew = Object();}deconcept.SWFObject=3Dfunction(_1,id,w,h,_5,c,_7,_8,_9,_a){if(!= document.getElementById){return;}this.DETECT_KEY=3D_a?_a:"detectflash";th= is.skipDetect=3Ddeconcept.util.getRequestParameter(this.DETECT_KEY);this.= params=3Dnew Object();this.variables=3Dnew = Object();this.attributes=3Dnew = Array();if(_1){this.setAttribute("swf",_1);}if(id){this.setAttribute("id"= ,id);}if(w){this.setAttribute("width",w);}if(h){this.setAttribute("height= ",h);}if(_5){this.setAttribute("version",new = deconcept.PlayerVersion(_5.toString().split(".")));}this.installedVer=3Dd= econcept.SWFObjectUtil.getPlayerVersion();if(!window.opera&&document.all&= &this.installedVer.major>7){deconcept.SWFObject.doPrepUnload=3Dtrue;}if(c= ){this.addParam("bgcolor",c);}var = q=3D_7?_7:"high";this.addParam("quality",q);this.setAttribute("useExpress= Install",false);this.setAttribute("doExpressInstall",false);var = _c=3D(_8)?_8:window.location;this.setAttribute("xiRedirectUrl",_c);this.s= etAttribute("redirectUrl","");if(_9){this.setAttribute("redirectUrl",_9);= }};deconcept.SWFObject.prototype=3D{useExpressInstall:function(_d){this.x= iSWFPath=3D!_d?"expressinstall.swf":_d;this.setAttribute("useExpressInsta= ll",true);},setAttribute:function(_e,_f){this.attributes[_e]=3D_f;},getAt= tribute:function(_10){return = this.attributes[_10];},addParam:function(_11,_12){this.params[_11]=3D_12;= },getParams:function(){return = this.params;},addVariable:function(_13,_14){this.variables[_13]=3D_14;},g= etVariable:function(_15){return = this.variables[_15];},getVariables:function(){return = this.variables;},getVariablePairs:function(){var _16=3Dnew Array();var = key;var _18=3Dthis.getVariables();for(key in = _18){_16[_16.length]=3Dkey+"=3D"+_18[key];}return = _16;},getSWFHTML:function(){var = _19=3D"";if(navigator.plugins&&navigator.mimeTypes&&navigator.mimeTypes.l= ength){if(this.getAttribute("doExpressInstall")){this.addVariable("MMplay= erType","PlugIn");this.setAttribute("swf",this.xiSWFPath);}_19=3D"

0){_19+=3D"flashvar= s=3D\""+_1c+"\"";}_19+=3D"/>";}else{if(this.getAttribute("doExpressInstal= l")){this.addVariable("MMplayerType","ActiveX");this.setAttribute("swf",t= his.xiSWFPath);}_19=3D"

";}return = _19;},write:function(_20){if(this.getAttribute("useExpressInstall")){var = _21=3Dnew = deconcept.PlayerVersion([6,0,65]);if(this.installedVer.versionIsValid(_21= )&&!this.installedVer.versionIsValid(this.getAttribute("version"))){this.= setAttribute("doExpressInstall",true);this.addVariable("MMredirectURL",es= cape(this.getAttribute("xiRedirectUrl")));document.title=3Ddocument.title= .slice(0,47)+" - Flash Player = Installation";this.addVariable("MMdoctitle",document.title);}}if(this.ski= pDetect||this.getAttribute("doExpressInstall")||this.installedVer.version= IsValid(this.getAttribute("version"))){var n=3D(typeof = _20=3D=3D"string")?document.getElementById(_20):_20;n.innerHTML=3Dthis.ge= tSWFHTML();return = true;}else{if(this.getAttribute("redirectUrl")!=3D""){document.location.r= eplace(this.getAttribute("redirectUrl"));}}return = false;}};deconcept.SWFObjectUtil.getPlayerVersion=3Dfunction(){var = _23=3Dnew = deconcept.PlayerVersion([0,0,0]);if(navigator.plugins&&navigator.mimeType= s.length){var x=3Dnavigator.plugins["Shockwave = Flash"];if(x&&x.description){_23=3Dnew = deconcept.PlayerVersion(x.description.replace(/([a-zA-Z]|\s)+/,"").replac= e(/(\s+r|\s+b[0-9]+)/,".").split("."));}}else{if(navigator.userAgent&&nav= igator.userAgent.indexOf("Windows CE")>=3D0){var axo=3D1;var = _26=3D3;while(axo){try{_26++;axo=3Dnew = ActiveXObject("ShockwaveFlash.ShockwaveFlash."+_26);_23=3Dnew = deconcept.PlayerVersion([_26,0,0]);}catch(e){axo=3Dnull;}}}else{try{var = axo=3Dnew = ActiveXObject("ShockwaveFlash.ShockwaveFlash.7");}catch(e){try{var = axo=3Dnew ActiveXObject("ShockwaveFlash.ShockwaveFlash.6");_23=3Dnew = deconcept.PlayerVersion([6,0,21]);axo.AllowScriptAccess=3D"always";}catch= (e){if(_23.major=3D=3D6){return _23;}}try{axo=3Dnew = ActiveXObject("ShockwaveFlash.ShockwaveFlash");}catch(e){}}if(axo!=3Dnull= ){_23=3Dnew deconcept.PlayerVersion(axo.GetVariable("$version").split(" = ")[1].split(","));}}}return = _23;};deconcept.PlayerVersion=3Dfunction(_29){this.major=3D_29[0]!=3Dnull= ?parseInt(_29[0]):0;this.minor=3D_29[1]!=3Dnull?parseInt(_29[1]):0;this.r= ev=3D_29[2]!=3Dnull?parseInt(_29[2]):0;};deconcept.PlayerVersion.prototyp= e.versionIsValid=3Dfunction(fv){if(this.majorfv.major){return = true;}if(this.minorfv.minor){return true;}if(this.rev=3D0;i--){_2f[i].style.display=3D"none";for(var x in = _2f[i]){if(typeof = _2f[i][x]=3D=3D"function"){_2f[i][x]=3Dfunction(){};}}}};if(deconcept.SWF= Object.doPrepUnload){if(!deconcept.unloadSet){deconcept.SWFObjectUtil.pre= pUnload=3Dfunction(){__flash_unloadHandler=3Dfunction(){};__flash_savedUn= loadHandler=3Dfunction(){};window.attachEvent("onunload",deconcept.SWFObj= ectUtil.cleanupSWFs);};window.attachEvent("onbeforeunload",deconcept.SWFO= bjectUtil.prepUnload);deconcept.unloadSet=3Dtrue;}}if(!document.getElemen= tById&&document.all){document.getElementById=3Dfunction(id){return = document.all[id];};}var = getQueryParamValue=3Ddeconcept.util.getRequestParameter;var = FlashObject=3Ddeconcept.SWFObject;var SWFObject=3Ddeconcept.SWFObject; 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