Nature Clinical = Practice Oncology | Metastasis: a therapeutic target for = cancer

Review

Nature=20 Clinical Practice Oncology (2008) 5, 206-219
doi:10.1038/ncponc1066 = 3D""=20

Received 16 = May 2007 |=20 Accepted 2 October 2007 | Published online: 5 February 2008

Metastasis: a = therapeutic target=20 for cancer

Patricia S Steeg* and = Dan=20 Theodorescu*

Correspondence *Laboratory of Molecular = Pharmacology,=20 National Cancer Institute, Room 1122, Building 37, 37 Convent Drive, = Bethesda,=20 MD 20892, USA

Email steegp@mail.nih.gov

Correspondence *University of Virginia, Room = 2561, 2nd=20 Floor, West Clinics, Hospital Drive, Charlottesville, VA 22908=960422, = USA=20

Email theodorescu@virginia.edu

Metastasis = remains the major=20 driver of mortality in patients with cancer. The similarities and = differences=20 between primary tumors and metastases are described, and pathways = controlling=20 the colonization of a distant organ and incorporation of anti-metastatic = therapies into clinical testing are discussed. The authors emphasize = that the=20 time is ripe for metastasis and metastatic colonization to enter = mainstream=20 clinical development and testing.

Full text of this article is available with one of the=20 following:

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Review

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