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WHO CLASSIFICATION



Classification of tumors of the CNS


The 2016 WHO Classification of Tumors of the CNS (PDF)





WHO 2016 TUMOR GROUPS



Diffuse astrocytic and oligodendroglial tumors
- Diffuse astrocytoma
-
Anaplastic astrocytoma
-
Glioblastoma (Giant cell glioblastoma, Gliosarcoma, Epithelioid glioblastoma)
- Diffuse midline glioma
-
Oligodendroglioma
- Anaplastic oligodendroglioma
- Oligoastrocytoma
- Anaplastic oligoastrocytoma




Other astrocytic tumors
- Pilocytic astrocytoma
(Pilomyxoid astrocytoma)
- Subependymal giant cell astrocytoma
(SEGA)
- Pleomorphic xanthoastrocytoma
(PXA)
- Anaplastic pleomorphic xantoastrocytoma




Ependymal tumors
- Subependymoma
- Myxopapillary ependymoma

-
Ependymoma
- Anaplastic ependymoma




Other gliomas
- Chordoid glioma of the third ventricle
- Angiocentric glioma
-
Astroblastoma




Choroid plexus tumors
- Choroid plexus papilloma
- Atypical choroid plexus papilloma
- Choroid plexus carcinoma




Neuronal and mixed neuronal-glial tumors
Dysembryoplastic neuroepithelial tumor
Gangliocytoma
Ganglioglioma

Anaplastic ganglioglioma
Dysplastic cerebellar gangliocytoma (Lhermitte-Ducloid disease)
Desmoplastic infantile astrocytoma and ganglioglioma
Papillary glioneural tumor
Rosette-forming glioneuronal tumor
Diffuse leptomeningeal glioneuronal tumor
Central neurocytoma
Extraventricular neurocytoma
Cerebellar liponeurocytoma

Paraganglioma




Tumors of the pineal region
- Pineocytoma
- Pineal parenchymal tumor of intermediate differentiation
- Pineoblastoma (PBL)
- Papillary tumor of the pineal region




Embryonal tumors
-
Medulloblastoma
- CNS embryonal tumor
-
Atypical teratoid rhabdoid tumor




Tumors of the cranial and paraspinal nerves
- Schwannoma




Meningiomas
-
Meningioma
- Meningothelial meningioma

- Anaplastic (malignant) meningioma




Mesenchymal, non meningothelial tumors
-
Hemangioma
- Hemangiopericytoma
- Ewing sarcoma – PNET
- Rhabdomyosarcoma




Melanocytic tumors




Lymphomas




Histiocytic tumors




Germ cell tumors
- Germinoma
- Yolk sac tumor
- Teratoma with malignant transformation




Tumors of the sellar region
- Craniopharyngioma




Metastatic tumors





OTHER GROUPS AND TUMORS



Brain tumors
- Classification of tumors of the CNS
- Pediatric brain tumors
-
Spinal cord tumors




Cancer




Gliofibroma




Gliomas
- Brainstem gliomas
- -
Diffuse intrinsic pontine gliomas
- -
Focal gliomas
- High-grade gliomas
- Low-grade gliomas




Lipoastrocytoma




Medullomyoblastoma