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Glioblastoma | Integrative medicine
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Monrás CA, Martín RS, Muñoz S, Niechi I, Howden J, Uribe DA, Erices JI, Arévalo ÁS.
Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme.
Curr Med Chem. 2017 Mar 3. doi: 10.2174/0929867324666170303122241. [Epub ahead of print]

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CHLOROTOXIN



Cohen-Inbar O, Zaaroor M.
Glioblastoma multiforme targeted therapy: The Chlorotoxin story.
J Clin Neurosci. 2016 Jul 21. pii: S0967-5868(16)30368-X. doi: 10.1016/j.jocn.2016.04.012. [Epub ahead of print]
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CURCUMIN



Alexandru O, Georgescu AM, Ene L, Purcaru SO, Serban F, Popescu A, Brindusa C, Tataranu LG, Ciubotaru V, Dricu A.
The effect of curcumin on low-passage glioblastoma cells in vitro.
J Cancer Res Ther. 2016 Apr-Jun;12(2):1025-32. doi: 10.4103/0973-1482.167609. Epub 2016 Jul 25.
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Daverey A, Agrawal SK.
Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes.
Neuroscience. 2016 Oct 1;333:92-103. doi: 10.1016/j.neuroscience.2016.07.012. Epub 2016 Jul 14.
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Dützmann S, Schiborr C, Kocher A, Pilatus U, Hattingen E, Weissenberger J, Geßler F, Quick-Weller J, Franz K, Seifert V, Frank J, Senft C.
Intratumoral Concentrations and Effects of Orally Administered Micellar Curcuminoids in Glioblastoma Patients.
Nutr Cancer. 2016 Jun 24:1-6. [Epub ahead of print]
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Eun CS, Lim JS, Lee J, Lee SP, Yang SA.
The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice.
BMC Complement Altern Med. 2017 Jul 17;17(1):367. doi: 10.1186/s12906-017-1880-3.
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Gersey ZC, Rodriguez GA, Barbarite E, Sanchez A, Walters WM, Ohaeto KC, Komotar RJ, Graham RM.
Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species.
BMC Cancer. 2017 Feb 4;17(1):99. doi: 10.1186/s12885-017-3058-2.
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Luthra PM, Lal N.
Prospective of curcumin, a pleiotropic signalling molecule from Curcuma longa in the treatment of Glioblastoma.
Eur J Med Chem. 2016 Feb 15;109:23-35. doi: 10.1016/j.ejmech.2015.11.049. Epub 2015 Dec 15.
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Rodriguez GA, Shah AH, Gersey ZC, Shah SS, Bregy A, Komotar RJ, Graham RM.
Investigating the therapeutic role and molecular biology of curcumin as a treatment for glioblastoma.
Ther Adv Med Oncol. 2016 Jul;8(4):248-60. doi: 10.1177/1758834016643518. Epub 2016 Apr 25.
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Sarisozen C, Dhokai S, Tsikudo EG, Luther E, Rachman IM, Torchilin VP.
Nanomedicine based curcumin and doxorubicin combination treatment of glioblastoma with scFv-targeted micelles: In vitro evaluation on 2D and 3D tumor models.
Eur J Pharm Biopharm. 2016 Aug 25. pii: S0939-6411(16)30464-7. doi: 10.1016/j.ejpb.2016.08.013. [Epub ahead of print]
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Wang Y, Ying X, Xu H, Yan H, Li X, Tang H.
The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals.
Int J Nanomedicine. 2017 Feb 17;12:1369-1384. doi: 10.2147/IJN.S124276.

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Zhang Z, Li C, Tan Q, Xie C, Yang Y, Zhan W, Han F, Sharma HS, Sharma A.
Curcumin suppresses tumor growth and angiogenesis in human glioma cells through modulation of vascular endothelial growth factor/angiopoietin-2/thrombospondin-1 signaling.
CNS Neurol Disord Drug Targets. 2016 Sep 2. [Epub ahead of print]
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CYCLOOXYGENASE-2



Qiu J, Shi Z, Jiang J.
Cyclooxygenase-2 in glioblastoma multiforme.
Drug Discov Today. 2016 Sep 28. pii: S1359-6446(16)30341-5. doi: 10.1016/j.drudis.2016.09.017. [Epub ahead of print]
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KETOGENIC DIET



Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, Brucker D, Walenta S, Kämmerer U, Coy JF, Weller M, Steinbach JP.
ERGO: a pilot study of ketogenic diet in recurrent glioblastoma.
Int J Oncol. 2014 Jun;44(6):1843-52. doi: 10.3892/ijo.2014.2382. Epub 2014 Apr 11. Erratum in: Int J Oncol. 2014
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MELATONIN



Zheng X, Pang B, Gu G, Gao T, Zhang R, Pang Q, Liu Q.
Melatonin Inhibits Glioblastoma Stem-like cells through Suppression of EZH2-NOTCH1 Signaling Axis.
Int J Biol Sci. 2017 Feb 6;13(2):245-253. doi: 10.7150/ijbs.16818. Ecollection.

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POMEGRANATE



Mota Ferreira L, Gehrcke M, Ferrari Cervi V, Eliete Rodrigues Bitencourt P, Ferreira da Silveira E, Hofstatter Azambuja J, Prates Ramos A, Nascimento K, Beatriz Moretto M, Braganhol E, Rorato Sagrillo M, Cruz L.
Pomegranate seed oil nanoemulsions with selective antiglioma activity: optimization and evaluation of cytotoxicity, genotoxicity and oxidative effects on mononuclear cells.
Pharm Biol. 2016 Jun 29:1-10. [Epub ahead of print]
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Concomitant pharmaceuticals



STATINS



Chang YL, Huang LC, Chen YC, Wang YW, Hueng DY, Huang SM.
The synergistic effects of valproic acid and fluvastatin on apoptosis induction in glioblastoma multiforme cell lines.
Int J Biochem Cell Biol. 2017 Oct 7;92:155-163. doi: 10.1016/j.biocel.2017.10.003. [Epub ahead of print]
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Lu VM, McDonald KL.
The current evidence of statin use affecting glioblastoma prognosis.
J Clin Neurosci. 2017 May 8. pii: S0967-5868(16)31219-X. doi: 10.1016/j.jocn.2017.04.036. [Epub ahead of print]
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Peng P, Wei W, Long C, Li J.
Atorvastatin augments temozolomide's efficacy in glioblastoma via prenylation-dependent inhibition of Ras signaling.
Biochem Biophys Res Commun. 2017 Jul 29;489(3):293-298. doi: 10.1016/j.bbrc.2017.05.147. Epub 2017 May 26.
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