BRAIN TUMOR LIBRARY
Gliomas | Treatment
48



Home > Brain tumor library > Gliomas > Treatment



OVERVIEWS


BRAINSTEM GLIOMAS
-
Diffuse intrinsic pontine gliomas


GLIOMATOSIS CEREBRI


HIGH-GRADE GLIOMAS


LOW-GRADE GLIOMAS





Overviews



Aquino D, Gioppo A, Finocchiaro G, Bruzzone MG, Cuccarini V.
MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives.
J Immunol Res. 2017;2017:5813951. doi: 10.1155/2017/5813951. Epub 2017 Apr 20.
Source | Abstract | Full text | Similar articles




Li G, Qin Z, Chen Z, Xie L, Wang R, Zhao H.
Tumor Microenvironment in Treatment of Glioma.
Open Med (Wars). 2017 Aug 12;12:247-251. doi: 10.1515/med-2017-0035. eCollection 2017.
Source | Abstract | Full text | Similar articles




Platten M, Bunse L, Wick W, Bunse T.
Concepts in glioma immunotherapy.
Cancer Immunol Immunother. 2016 Jul 26. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Uhm JH, Porter AB.
Treatment of Glioma in the 21st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era.
Mayo Clin Proc. 2017 Jun;92(6):995-1004. doi: 10.1016/j.mayocp.2017.01.010
Source | Abstract | Full text | Similar articles





ANTINEOPLASTIC EFFECTS OF ANTIEPILEPTIC DRUGS



Rizzo A, Donzelli S, Girgenti V, Sacconi A, Vasco C, Salmaggi A, Blandino G, Maschio M, Ciusani E.
In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells.
J Exp Clin Cancer Res. 2017 Jun 6;36(1):76. doi: 10.1186/s13046-017-0546-9.
Source | Abstract | Full text | Similar articles





HIPPOCAMPUS



Karunamuni RA, Seibert TM, White NS, McEvoy L, Farid N, Brewer J, Dale AM, McDonald CR, Hattangadi-Gluth JA.
Abnormalities in hippocampal volume of glioma patients prior to radiotherapy.
Acta Oncol. 2017 Mar;56(3):427-430. doi: 10.1080/0284186X.2017.1280847. Epub 2017 Feb 3.
Source | Abstract | Full text | Similar articles





MGMT



Li Q, Guo J, Wang W, Wang D.
Relationship between MGMT gene expression and treatment effectiveness and prognosis in glioma.
Oncol Lett. 2017 Jul;14(1):229-233. doi: 10.3892/ol.2017.6123. Epub 2017 May 5.
Source | Abstract | Full text | Similar articles





MITOXANTRONE



Ellis JA, Cooke J, Singh-Moon RP, Wang M, Bruce JN, Emala CW, Bigio IJ, Joshi S.
Safety, feasibility, and optimization of intra-arterial mitoxantrone delivery to gliomas.
J Neurooncol. 2016 Dec;130(3):449-454. Epub 2016 Aug 30.
Source | Abstract | Full text | Similar articles





NERVE GROWTH FACTOR



Falsini B, Chiaretti A, Rizzo D, Piccardi M, Ruggiero A, Manni L, Soligo M, Dickmann A, Federici M, Salerni A, Timelli L, Guglielmi G, Lazzareschi I, Caldarelli M, Galli-Resta L, Colosimo C, Riccardi R.
Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial.
Brain. 2016 Feb;139(Pt 2):404-14. doi: 10.1093/brain/awv366. Epub 2016 Jan 14.
Source | Abstract | Full text | Similar articles





VENOUS THROMBOEMBOLISM



Al Megren M, De Wit C, Al Qahtani M, Le Gal G, Carrier M.
Management of venous thromboembolism in patients with glioma.
Thromb Res. 2017 Jun 8;156:105-108. doi: 10.1016/j.thromres.2017.06.010. [Epub ahead of print]
Source | Abstract | Full text | Similar articles





Brainstem gliomas




Upadhyaya SA, Koschmann C, Muraszko K, Venneti S, Garton HJ, Hamstra DA, Maher CO, Betz BL, Brown NA, Wahl D, Weigelin HC, DuRoss KE, Leonard AS, Robertson PL.
Brainstem Low-Grade Gliomas in Children-Excellent Outcomes With Multimodality Therapy.
J Child Neurol. 2017 Feb;32(2):194-203. doi: 10.1177/0883073816675547. Epub 2016 Nov 3.
Source | Abstract | Full text | Similar articles



RADIOTHERAPY



Hu X, Fang Y, Hui X, Jv Y, You C.
Radiotherapy for diffuse brainstem glioma in children and young adults.
Cochrane Database Syst Rev. 2016 Jun 27;6:CD010439. [Epub ahead of print]
Source | Abstract | Full text (Protocol, 2013) | Similar articles




Phuong PC, Hung NQ, Ngoc TB, Rades D, Khoa MT.
Rotating Gamma System Irradiation: A Promising Treatment for Low-grade Brainstem Gliomas.
In Vivo. 2017 Sep-Oct;31(5):957-960.
Source | Abstract | Full text | Similar articles



SURGERY (BIOPSY)



Quick-Weller J, Tritt S, Behmanesh B, Mittelbronn M, Spyrantis A, Dinc N, Weise L, Seifert V, Marquardt G, Freiman TM.
Biopsies of pediatric brainstem lesions display low morbidity but strong impact on further treatment decisions.
J Clin Neurosci. 2017 Oct;44:254-259. doi: 10.1016/j.jocn.2017.06.028. Epub 2017 Jul 12.
Source | Abstract | Full text | Similar articles



Diffuse intrinsic pontine gliomas



OVERVIEWS



Long W, Yi Y, Chen S, Cao Q, Zhao W, Liu Q.
Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma.
Front Pharmacol. 2017 Jul 25;8:495. doi: 10.3389/fphar.2017.00495. eCollection 2017.
Source | Abstract | Full text | Similar articles




PDQ Pediatric Treatment Editorial Board.
Childhood Brain Stem Glioma Treatment (PDQ®): Patient Version.
PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-2016 May 18.
Source | Abstract | Full text | Similar articles




PDQ Pediatric Treatment Editorial Board.
Childhood Brain Stem Glioma Treatment (PDQ®): Health Professional Version.
PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-2016 May 18.
Source | Abstract | Full text | Similar articles




LABORATORY INVESTIGATIONS


Hashizume R.
Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma.
Neurol Med Chir (Tokyo). 2017 Jun 7. doi: 10.2176/nmc.ra.2017-0018. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



CHEMOTHERAPY


**

Sewing AC, Lagerweij T, van Vuurden DG, Meel MH, Veringa SJ, Carcaboso AM, Gaillard PJ, Peter Vandertop W, Wesseling P, Noske D, Kaspers GJ, Hulleman E.
Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma.
J Neurosurg Pediatr. 2017 Feb 17:1-13. doi: 10.3171/2016.9.PEDS16152. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Veldhuijzen van Zanten SEM, El-Khouly FE, Jansen MHA, Bakker DP, Sanchez Aliaga E, Haasbeek CJA, Wolf NI, Zwaan CM, Vandertop WP, van Vuurden DG, Kaspers GJL.
A phase I/II study of gemcitabine during radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma.
J Neurooncol. 2017 Jul 26. doi: 10.1007/s11060-017-2575-9. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



RADIOTHERAPY



Freese C, Takiar V, Fouladi M, DeWire M, Breneman J, Pater L.
Radiation and subsequent reirradiation outcomes in the treatment of diffuse intrinsic pontine glioma and a systematic review of the reirradiation literature.
Pract Radiat Oncol. 2017 Mar - Apr;7(2):86-92. doi: 10.1016/j.prro.2016.11.005. Epub 2016 Nov 23.
Source | Abstract | Full text | Similar articles




Janssens GO, Gandola L, Bolle S, Mandeville H, Ramos-Albiac M, van Beek K, Benghiat H, Hoeben B, Morales La Madrid A, Kortmann RD, Hargrave D, Menten J, Pecori E, Biassoni V, von Bueren AO, van Vuurden DG, Massimino M, Sturm D, Peters M, Kramm CM.
Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group.
Eur J Cancer. 2017 Mar;73:38-47. doi: 10.1016/j.ejca.2016.12.007. Epub 2017 Feb 3.
Source | Abstract | Full text | Similar articles




Morales La Madrid A, Santa-María V, Cruz Martinez O, Mora J, Puerta Roldan P, Guillen Quesada A, Suñol Capella M, de Torres Gomez-Pallete C, Lassaletta A, Laperriere N, Villà S, Bouffet E.
Second re-irradiation for DIPG progression, re-considering "old strategies" with new approaches.
Childs Nerv Syst. 2017 Mar 1. doi: 10.1007/s00381-017-3352-y. [Epub ahead of print]

Source | Abstract | Full text | Similar articles




Tinkle CL, Orr BA, Lucas JT Jr, Klimo P, Patay Z, Baker SJ, Broniscer A, Qaddoumi I.
Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma.
Pediatr Blood Cancer. 2017 Jan 13. doi: 10.1002/pbc.26416. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Wang ZJ, Ge Y, Altinok D, Poulik J, Sood S, Taub JW, Edwards H, Kieran MW, Steven M.
Concomitant Use of Panobinostat and Reirradiation in Progressive DIPG: Report of 2 Cases.
J Pediatr Hematol Oncol. 2017 Feb 23. doi: 10.1097/MPH.0000000000000806. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



Gliomatosis cerebri



BEVACIZUMAB



Burger MC, Mildenberger IC, Wagner M, Mittelbronn M, Steinbach JP, Bähr O.
Bevacizumab for Patients with Recurrent Gliomas Presenting with a Gliomatosis Cerebri Growth Pattern.
Int J Mol Sci. 2017 Mar 29;18(4). pii: E726. doi: 10.3390/ijms18040726.
Source | Abstract | Full text | Similar articles





High-grade gliomas



Overviews



Khan MN, Sharma AM, Pitz M, Loewen SK, Quon H, Poulin A, Essig M.
High-grade glioma management and response assessment-recent advances and current challenges.
Curr Oncol. 2016 Aug;23(4):e383-91. doi: 10.3747/co.23.3082. Epub 2016 Aug 12.
Source | Abstract | Full text | Similar articles




CHEMOTHERAPY


Bouffet E, Ramaswamy V.
Old chemotherapy makes a comeback: dual alkylator therapy for pediatric high-grade glioma.
Neuro Oncol. 2016 Oct;18(10):1333-4. doi: 10.1093/neuonc/now200.
Source | Abstract | Full text | Similar articles




Wen W, Guang S, Binbin M, Xiangcheng H, Xin D, Bo Z.
Chemotherapy for Adults with Malignant Glioma: A Systematic Review and Network Meta-analysis.
Turk Neurosurg. 2015 Aug 25. doi: 10.5137/1019-5149.JTN.15462-15.0. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




IMMUNOTHERAPY


Lin Y, Okada H.
Cellular immunotherapy for malignant gliomas.
Expert Opin Biol Ther. 2016 Jul 29:1-11. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




SURGERY


Renfrow JJ, Strowd RE, Laxton AW, Tatter SB, Geer CP, Lesser GJ.
Surgical Considerations in the Optimal Management of Patients with Malignant Brain Tumors.
Curr Treat Options Oncol. 2017 Aug;18(8):46. doi: 10.1007/s11864-017-0487-8. Online 2017 Jul 5.
Source | Abstract | Full text | Similar articles




TARGETED THERAPY


Chen R, Cohen AL, Colman H.
Targeted Therapeutics in Patients With High-Grade Gliomas: Past, Present, and Future.
Curr Treat Options Oncol. 2016 Aug;17(8):42. doi: 10.1007/s11864-016-0418-0. Epub 2016 Jun 22
Source | Abstract | Full text | Similar articles





Laboratory investigations



DIFFERENTIATION



Wang Y, Huang N, Li H, Liu S, Chen X, Yu S, Wu N, Bian XW, Shen HY, Li C, Xiao L.
Promoting oligodendroglial-oriented differentiation of glioma stem cell: A repurposing of quetiapine for the treatment of malignant glioma.
Oncotarget. 2017 Mar 21. doi: 10.18632/oncotarget.16400. [Epub ahead of print]
Source | Abstract | Full text | Similar articles





Clinical investigations



ANTIANGIOGENIC THERAPY



Yonezawa H, Hirano H, Uchida H, Habu M, Hanaya R, Oyoshi T, Sadamura Y, Hanada T, Tokimura H, Moinuddin F, Arita K.
Efficacy of bevacizumab therapy for unresectable malignant glioma: A retrospective analysis.
Mol Clin Oncol. 2017 Jan;6(1):105-110. doi: 10.3892/mco.2016.1086. Epub 2016 Nov 18.
Source | Abstract | Full text | Similar articles



CHEMOTHERAPY



Xu W, Li T, Gao L, Zheng J, Shao A, Zhang J.
Efficacy and safety of long-term therapy for high-grade glioma with temozolomide: A meta-analysis.
Oncotarget. 2017 Apr 24;8(31):51758-51765. doi: 10.18632/oncotarget.17401. eCollection 2017 Aug 1.
Source
| Abstract | Full text | Similar articles



PEDIATRIC PATIENTS



Jakacki RI, Cohen KJ, Buxton A, Krailo MD, Burger PC, Rosenblum MK, Brat DJ, Hamilton RL, Eckel SP, Zhou T, Lavey RS, Pollack IF.
Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study.
Neuro Oncol. 2016 Mar 22. pii: now038. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Massimino M, Biassoni V.
Use of high-dose chemotherapy in front-line therapy of childhood malignant glioma.
Expert Rev Anticancer Ther. 2006 May;6(5):709-17.
Source | Abstract | Full text | Similar articles




Massimino M, Gandola L, Luksch R, Spreafico F, Riva D, Solero C, Giangaspero F, Locatelli F, Podda M, Bozzi F, Pignoli E, Collini P, Cefalo G, Zecca M, Casanova M, Ferrari A, Terenziani M, Meazza C, Polastri D, Scaramuzza D, Ravagnani F, Fossati-Bellani F.
Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma.
Neuro Oncol. 2005 Jan;7(1):41-8.
Source | Abstract | Full text | Similar articles



RADIOTHERAPY



Adeberg S, Harrabi SB, Bougatf N, Bernhardt D, Rieber J, Koerber SA, Syed M, Sprave T, Mohr A, Abdollahi A, Haberer T, Combs SE, Herfarth K, Debus J, Rieken S.
Intensity-modulated proton therapy, volumetric-modulated arc therapy, and 3D conformal radiotherapy in anaplastic astrocytoma and glioblastoma : A dosimetric comparison.
Strahlenther Onkol. 2016 Nov;192(11):770-779. Epub 2016 Jun 22.
Source | Abstract | Full text | Similar articles



***

Nathan JK, Brezzell AL, Kim MM, Leung D, Wilkinson DA, Hervey-Jumper SL.
Early initiation of chemoradiation following index craniotomy is associated with decreased survival in high-grade glioma.
J Neurooncol. 2017 Jul 25. doi: 10.1007/s11060-017-2577-7. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



WITHAFERIN A



Marlow MM, Shah SS, Véliz EA, Ivan ME, Graham RM.
Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives.
J Nat Med. 2016 Jul 2. [Epub ahead of print]
Source | Abstract | Full text | Similar articles





Recurrent tumors



OVERVIEWS



Schwartz C, Thon N, Winkler PA.
Therapeutic Options for Recurrent High-grade Gliomas - A Perspective Statement.
World Neurosurg. 2017 Apr 19. pii: S1878-8750(17)30571-5. doi: 10.1016/j.wneu.2017.04.076. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



ANTI-ANGIOGIENIC THERAPY



de Lemos ML, Markarian A, Chan E, Schaff K, Walisser S.
Clinical effectiveness of bevacizumab in patients with recurrent brain tumours: A population-based evaluation.
J Oncol Pharm Pract. 2016 Nov 30. pii: 1078155216681191. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



BRACHYTHERAPY



Suchorska B, Hamisch C, Treuer H, Mahnkopf K, Lehrke RE, Kocher M, Ruge MI, Voges J.
Stereotactic brachytherapy using iodine 125 seeds for the treatment of primary and recurrent anaplastic glioma WHO° III.
J Neurooncol. 2016 Oct;130(1):123-131. Epub 2016 Jul 15.
Source | Abstract | Full text | Similar articles



CHEMOTHERAPY



Aoki T, Arakawa Y, Ueba T, Oda M, Nishida N, Akiyama Y, Tsukahara T, Iwasaki K, Mikuni N, Miyamoto S.
Phase I/II Study of Temozolomide Plus Nimustine Chemotherapy for Recurrent Malignant Gliomas: Kyoto Neuro-oncology Group.
Neurol Med Chir (Tokyo). 2016 Oct 11. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Chamberlain MC, Colman H, Kim BT, Raizer J.
Salvage therapy with bendamustine for temozolomide refractory recurrent anaplastic gliomas: a prospective phase II trial.
J Neurooncol. 2017 Feb 16. doi: 10.1007/s11060-016-2241-7. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Parasramka S, Talari G, Rosenfeld M, Guo J, Villano JL.
Procarbazine, lomustine and vincristine for recurrent high-grade glioma.
Cochrane Database Syst Rev. 2017 Jul 26;7:CD011773. doi: 10.1002/14651858.CD011773.pub2.
Source | Abstract | Full text | Similar articles




Wong ET, Timmons J, Callahan A, O'Loughlin L, Giarusso B, Alsop DC.
Phase I study of low-dose metronomic temozolomide for recurrent malignant gliomas.
BMC Cancer. 2016 Nov 22;16(1):914.
Source | Abstract | Full text | Similar articles



GENE THERAPY



Portnow J, Synold TW, Badie B, Tirughana R, Lacey SF, D'Apuzzo M, Metz MZ, Najbauer J, Bedell V, Vo T, Gutova M, Frankel P, Chen MY, Aboody KS.
Neural stem cell-based anti-cancer gene therapy: a first-in-human study in recurrent high grade glioma patients.
Clin Cancer Res. 2016 Dec 15. pii: clincanres.1518.2016. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



HISTONE DEACETYLASE INHIBITORS



PANOBINOSTAT


Shi W, Palmer JD, Werner-Wasik M, Andrews DW, Evans JJ, Glass J, Kim L, Bar-Ad V, Judy K, Farrell C, Simone N, Liu H, Dicker AP, Lawrence YR.
Phase I trial of panobinostat and fractionated stereotactic re-irradiation therapy for recurrent high grade gliomas.
J Neurooncol. 2016 May;127(3):535-9. doi: 10.1007/s11060-016-2059-3. Epub 2016 Jan 29.
Source | Abstract | Full text | Similar articles



IMMUNOTHERAPY



Cloughesy TF, Landolfi J, Hogan DJ, Bloomfield S, Carter B, Chen CC, Elder JB, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu PL, Piccioni D, Walbert T, Chu A, Das A, Diago OR, Gammon D, Gruber HE, Hanna M, Jolly DJ, Kasahara N, McCarthy D, Mitchell L, Ostertag D, Robbins JM, Rodriguez-Aguirre M, Vogelbaum MA.
Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma.
Sci Transl Med. 2016 Jun 1;8(341):341ra75. doi: 10.1126/scitranslmed.aad9784.
Source | Abstract | Full text | Similar articles




Fenstermaker RA, Ciesielski MJ, Qiu J, Yang N, Frank CL, Lee KP, Mechtler LR, Belal A, Ahluwalia MS, Hutson AD.
Clinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant glioma.
Cancer Immunol Immunother. 2016 Nov;65(11):1339-1352. Epub 2016 Aug 30.
Source | Abstract | Full text | Similar articles




Strebe JK, Lubin JA, Kuo JS.
"Tag Team" Glioblastoma Therapy: Results From a Phase 1 Trial of Toca 511 and 5-Fluorocytosine for Recurrent High-Grade Glioma.
Neurosurgery. 2016 Dec;79(6):N18-N20.
Source | Abstract | Full text | Similar articles



LASER ABLATION



Rodriguez A, Tatter SB.
Laser Ablation of Recurrent Malignant Gliomas: Current Status and Future Perspective.
Neurosurgery. 2016 Dec;79 Suppl 1:S35-S39.
Source | Abstract | Full text | Similar articles



LASER THERMAL THERAPY



Lee I, Kalkanis S, Hadjipanayis CG.
Stereotactic Laser Interstitial Thermal Therapy for Recurrent High-Grade Gliomas.
Neurosurgery. 2016 Dec;79 Suppl 1:S24-S34.
Source | Abstract | Full text | Similar articles



NOTCH SIGNALING INHIBITORS



Pan E, Supko JG, Kaley TJ, Butowski NA, Cloughesy T, Jung J, Desideri S, Grossman S, Ye X, Park DM.
Phase I study of RO4929097 with bevacizumab in patients with recurrent malignant glioma.
J Neurooncol. 2016 Dec;130(3):571-579. Epub 2016 Nov 8.
Source | Abstract | Full text | Similar articles



RADIOTHERAPY



Dong Y, Fu C, Guan H, Zhang T, Zhang Z, Zhou T, Li B.
Re-irradiation alternatives for recurrent high-grade glioma.
Oncol Lett. 2016 Oct;12(4):2261-2270.
Source | Abstract | Full text | Similar articles



VEGFR INHIBITORS



Zhang H, Chen F, Wang Z, Wu S.
Successful treatment with apatinib for refractory recurrent malignant gliomas: a case series.
Onco Targets Ther. 2017 Feb 14;10:837-845. doi: 10.2147/OTT.S119129. eCollection

Source | Abstract | Full text | Similar articles





Low-grade gliomas



Overviews



Choucair AK.
Low grade glioma: a journey towards a cure.
Chin Clin Oncol. 2017 Aug;6(4):43. doi: 10.21037/cco.2017.07.08.
Source | Abstract | Full text | Similar articles




Schiff D.
Molecular profiling optimizes the treatment of low-grade glioma.
Neuro Oncol. 2016 Dec;18(12):1593-1594. Epub 2006 Nov 8.
Source | Abstract | Full text | Similar articles



CHEMOTHERAPY



Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr.
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
N Engl J Med. 2016 Apr 7;374(14):1344-55. doi: 10.1056/NEJMoa1500925.
Comments and authors reply.
Source | Abstract | Full text | Similar articles | Correspondence




Gnekow AK, Walker DA, Kandels D, Picton S, Giorgio Perilongo, Grill J, Stokland T, Sandstrom PE, Warmuth-Metz M, Pietsch T, Giangaspero F, Schmidt R, Faldum A, Kilmartin D, De Paoli A, De Salvo GL; of the Low Grade Glioma Consortium and the participating centers.
A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma - A final report.
Eur J Cancer. 2017 Aug;81:206-225. doi: 10.1016/j.ejca.2017.04.019. Epub 2017 Jun 22.
Source | Abstract | Full text | Similar articles




Mora J, Perez-Jaume S, Cruz O.
Treatment of childhood astrocytomas with irinotecan and cisplatin.
Clin Transl Oncol. 2017 Aug 21. doi: 10.1007/s12094-017-1741-z. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Villani V, Merola R, Vidiri A, Fabi A, Carosi M, Giannarelli D, Marucci L, Maschio M, Carapella CM, Pace A.
Temozolomide low-dose chemotherapy in newly diagnosed low-grade gliomas: activity, safety, and long-term follow-up.
Tumori. 2016 Sep 22:0. doi: 10.5301/tj.5000565. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




CHEMOTHERAPY VERSUS RADIOTHERAPY


Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJ, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R.
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Lancet Oncol. 2016 Nov;17(11):1521-1532. doi: 10.1016/S1470-2045(16)30313-8. Epub 2016 Sep 27.
Source | Abstract | Full text | Similar articles



RADIOTHERAPY



Harrabi SB, Bougatf N, Mohr A, Haberer T, Herfarth K, Combs SE, Debus J, Adeberg S.
Dosimetric advantages of proton therapy over conventional radiotherapy with photons in young patients and adults with low-grade glioma.
Strahlenther Onkol. 2016 Nov;192(11):759-769. Epub 2016 Jun 30.
Source | Abstract | Full text | Similar articles




PSEUDOPROGRESSION


Tsang DS, Murphy ES, Lucas JT Jr, Lagiou P, Acharya S, Merchant TE.
Pseudoprogression in pediatric low-grade glioma after irradiation.
J Neurooncol. 2017 Jul 27. doi: 10.1007/s11060-017-2583-9. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



RADIOSURGERY



Gagliardi F, Bailo M, Spina A, Donofrio CA, Boari N, Franzin A, Fava A, Vecchio AD, Bolognesi A, Mortini P.
Gamma Knife Radiosurgery for Low-Grade Gliomas: Clinical Results at Long-Term Follow-Up on Tumor Control and Patients' Quality of Life.
World Neurosurg. 2017 Feb 16. pii: S1878-8750(17)30203-6. doi: 10.1016/j.wneu.2017.02.041. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



SURGERY



Brokinkel B, Yavuz M, Warneke N, Brentrup A, Hess K, Bleimüller C, Wölfer J, Stummer W.
Endoscopic management of a low-grade thalamic glioma: a safe alternative to open microsurgery?
Acta Neurochir (Wien). 2017 Feb 24. doi: 10.1007/s00701-017-3120-5. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Jakola AS, Skjulsvik AJ, Myrmel KS, Sjåvik K, Unsgård G, Torp SH, Aaberg K, Berg T, Dai HY, Johnsen K, Kloster R, Solheim O.
Surgical resection versus watchful waiting in low-grade gliomas.
Ann Oncol. 2017 May 5. doi: 10.1093/annonc/mdx230. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Jiang B, Chaichana K, Veeravagu A, Chang SD, Black KL, Patil CG.
Biopsy versus resection for the management of low-grade gliomas.
Cochrane Database Syst Rev. 2017 Apr 27;4:CD009319. doi: 10.1002/14651858.CD009319.pub3.
Source | Abstract | Full text | Similar articles




Weller M.
Surgery for patients with "lower grade" glioma: putting assumptions, beliefs and convictions into perspective.
Ann Oncol. 2017 Jun 16. doi: 10.1093/annonc/mdx295. [Epub ahead of print]
Source | Abstract | Full text | Similar articles




Wijnenga MM, Mattni T, French PJ, Rutten GJ, Leenstra S, Kloet F, Taphoorn MJ, van den Bent MJ, Dirven CM, van Veelen ML, Vincent AJ.
Does early resection of presumed low-grade glioma improve survival? A clinical perspective.
J Neurooncol. 2017 Apr 11. doi: 10.1007/s11060-017-2418-8. [Epub ahead of print]
Source | Abstract | Full text | Similar articles





Recurrent tumors



RADIOTHERAPY



Tsang DS, Murphy ES, Ezell SE, Lucas JT Jr, Tinkle C, Merchant TE.
Craniospinal irradiation for treatment of metastatic pediatric low-grade glioma.
J Neurooncol. 2017 Jun 17. doi: 10.1007/s11060-017-2525-6. [Epub ahead of print]
Source | Abstract | Full text | Similar articles



SURGERY



Uppstrom TJ, Singh R, Hadjigeorgiou GF, Magge R, Ramakrishna R.
Repeat surgery for recurrent low-grade gliomas should be standard of care.
Clin Neurol Neurosurg. 2016 Dec;151:18-23. doi: 10.1016/j.clineuro.2016.09.013.
Source | Abstract | Full text | Similar articles