BRAIN TUMOR LIBRARY
Medulloblastoma | Prognosis
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OVERVIEW



Yu J, Zhao R, Shi W, Li H.
Risk factors for the prognosis of pediatric medulloblastoma: a retrospective analysis of 40 cases.
Clinics (Sao Paulo). 2017 May;72(5):294-304. doi: 10.6061/clinics/2017(05)07.
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ADULT PATIENTS



De B, Beal K, De Braganca KC, Souweidane MM, Dunkel IJ, Khakoo Y, Gilheeney SW, DeAngelis LM, Menzel P, Patel SH, Wolden SL.
Long-term outcomes of adult medulloblastoma patients treated with radiotherapy.
J Neurooncol. 2017 Oct 10. doi: 10.1007/s11060-017-2627-1. [Epub ahead of print]
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Mallick S, Gandhi AK, Benson R, Sharma DN, Haresh KP, Gupta S, Julka PK, Rath GK.
Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience.
South Asian J Cancer. 2015 Oct-Dec;4(4):174-8. doi: 10.4103/2278-330X.175954.
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PEDIATRIC PATIENTS



Huang PI, Lin SC, Lee YY, Ho DM, Guo WY, Chang KP, Chang FC, Liang ML, Chen HH, Liu YM, Yen SH, Wong TT, Chen YW.
Large cell/anaplastic medulloblastoma is associated with poor prognosis-a retrospective analysis at a single institute.
Childs Nerv Syst. 2017 May 9. doi: 10.1007/s00381-017-3435-9. [Epub ahead of print]
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Stensvold E, Krossnes BK, Lundar T, Due-Tønnessen BJ, Frič R, Due-Tønnessen P, Bechensteen AG, Myklebust TÅ, Johannesen TB, Brandal P.
Outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS-PNET) - a retrospective analysis spanning 40 years of treatment.
Acta Oncol. 2017 May;56(5):698-705. doi: 10.1080/0284186X.2017.1301679. Epub 2017 Mar 21.
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HISTOLOGICAL VARIANTS



Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F.
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators.
Pediatr Blood Cancer. 2013 Feb;60(2):210-6. doi: 10.1002/pbc.24225. Epub 2012 Jun 12.
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POSTOPERATIVE RADIOTHERAPY



Eaton BR, Esiashvili N, Kim S, Weyman EA, Thornton LT, Mazewski C, MacDonald T, Ebb D, MacDonald SM, Tarbell NJ, Yock TI.
Clinical Outcomes Among Children With Standard-Risk Medulloblastoma Treated With Proton and Photon Radiation Therapy: A Comparison of Disease Control and Overall Survival.
Int J Radiat Oncol Biol Phys. 2016 Jan 1;94(1):133-8. doi: 10.1016/j.ijrobp.2015.09.014. Epub 2015 Sep 18.
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Kann BH, Park HS, Lester-Coll NH, Yeboa DN, Benitez V, Khan AJ, Bindra RS, Marks AM, Roberts KB.
Postoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children.
JAMA Oncol. 2016 Aug 4. doi: 10.1001/jamaoncol.2016.2547. [Epub ahead of print]
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Paulino AC, Jaboin JJ.
Radiotherapy Deferral in Medulloblastoma.
JAMA Oncol. 2016 Aug 4. doi: 10.1001/jamaoncol.2016.2546. [Epub ahead of print]
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RELAPSE PATTERN



Mokhtech M, Morris CG, Indelicato DJ, Rutenberg MS, Amdur RJ.
Patterns of Failure in Patients With Adult Medulloblastoma Presenting Without Extraneural Metastasis.
Am J Clin Oncol. 2017 Oct 17. doi: 10.1097/COC.0000000000000407. [Epub ahead of print]
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Only 10% of medulloblastomas present in adults but most treatment recommendations are extrapolated from the experience in pediatric patients. The purpose of our study is to evaluate long-term outcomes in patients treated with radiation therapy for medulloblastoma that was diagnosed in the adult age range with particular focus on pattern of tumor recurrence.




Ramaswamy V, Remke M, Bouffet E, Faria CC, Perreault S, Cho YJ, Shih DJ, Luu B, Dubuc AM, Northcott PA, Schüller U, Gururangan S, McLendon R, Bigner D, Fouladi M, Ligon KL, Pomeroy SL, Dunn S, Triscott J, Jabado N, Fontebasso A, Jones DT, Kool M, Karajannis MA, Gardner SL, Zagzag D, Nunes S, Pimentel J, Mora J, Lipp E, Walter AW, Ryzhova M, Zheludkova O, Kumirova E, Alshami J, Croul SE, Rutka JT, Hawkins C, Tabori U, Codispoti KE, Packer RJ, Pfister SM, Korshunov A, Taylor MD.
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.
Lancet Oncol. 2013 Nov;14(12):1200-7. doi: 10.1016/S1470-2045(13)70449-2. Epub 2013 Oct 17. Erratum in: Lancet Oncol. 2014 Apr;15(4):e154.
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Sabel M, Fleischhack G, Tippelt S, Gustafsson G, Doz F, Kortmann R, Massimino M, Navajas A, von Hoff K, Rutkowski S, Warmuth-Metz M, Clifford SC, Pietsch T, Pizer B, Lannering B; SIOP-E Brain Tumour Group.
Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study.
J Neurooncol. 2016 Sep;129(3):515-24. doi: 10.1007/s11060-016-2202-1. Epub 2016 Jul 16.
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Zollo M.
Genetics of recurrent medulloblastoma.
Lancet Oncol. 2013 Nov;14(12):1147-8. doi: 10.1016/S1470-2045(13)70482-0. Epub 2013 Oct 17.
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