| World
Health Organization
Classification of Tumors of the Nervous System
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From:
Kleihues P, Cavenee WK, eds.
Pathology and genetics of tumours of the nervous system
World Health Organization classification of tumours
Lyon, France: IARC Press, 2000
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Contents |
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Tumors
of Neuroepithelial Tissue |
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Astrocytic
Tumors |
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| 1 |
9400/3(*) |
Diffuse Astrocytoma |
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| (Variant) |
9420/3 |
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Fibrillary Astrocytoma |
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| (Variant) |
9410/3 |
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Protoplasmatic Astrocytoma |
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| (Variant) |
9411/3 |
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Gemistocytic Astrocytoma |
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| 2 |
9401/3 |
Anaplastic Astrocytoma |
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| 3 |
9440/3 |
Glioblastoma |
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| (Variant) |
9441/3 |
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Giant Cell Glioblastoma |
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| (Variant) |
9442/3 |
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Gliosarcoma |
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| 4 |
9421/1 |
Pilocytic Astrocytoma |
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| 5 |
9424/3 |
Pleomorphic Xanthoastrocytoma |
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| 6 |
9384/1 |
Subependymal Giant Cell Astrocytoma |
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Oligodendroglial
Tumors |
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| 7 |
9450/3 |
Oligodendroglioma |
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| 8 |
9451/3 |
Anaplastic Oligodendroglioma |
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Mixed Gliomas |
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| 9 |
9382/3 |
Oligoastrocytoma |
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| 10 |
9382/3(**) |
Anaplastic Oligoastrocytoma |
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Ependymal
Tumors |
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| 11 |
9391/3 |
Ependymoma |
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| (Variant) |
9391/3 |
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Cellurar |
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| (Variant) |
9393/3 |
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Papillary |
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| (Variant) |
9391/3 |
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Clear Cell |
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| (Variant) |
9391/3 |
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Tanycytic |
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| 12 |
9392/3 |
Anaplastic Ependymoma |
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| 13 |
9394/1 |
Myxopapillary Ependymoma |
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| 14 |
9383/1 |
Subependymoma |
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Choroid Plexus
Tumors |
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| 15 |
9390/0 |
Choroid Plexus Papilloma |
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| 16 |
9390/3 |
Choroid Plexus Carcinoma |
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Glial Tumors of Uncertain Origin |
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| 17 |
9430/3 |
Astroblastoma |
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| 18 |
9381/3 |
Gliomatosis Cerebri |
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| 19 |
9444/1 |
Chordoid Glioma of the Third Ventricle |
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Neuronal and Mixed Neuronal-Glial Tumors |
| 20 |
9492/0 |
Gangliocytoma |
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| 21 |
9493/0 |
Dysplastic Gangliocytoma of Cerebellum
(Lhermitte-Duclos) |
| 22 |
9412/1 |
Desmoplastic Infantile Astrocytoma /
Ganglioglioma |
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| 23 |
9413/0 |
Dysembryoplastic Neuroepithelial Tumor |
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| 24 |
9505/1 |
Ganglioglioma |
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| 25 |
9505/3 |
Anaplastic Ganglioglioma |
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| 26 |
9506/1 |
Central Neurocytoma |
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| 27 |
9506/1 |
Cerebellar Liponeurocytoma |
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| 28 |
8680/1 |
Paraganglioma of the Filum Terminale |
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Neuroblastic Tumors |
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| 29 |
9522/3 |
Olfactory Neuroblastoma
(Aaesthesioneuroblastoma) |
| 30 |
9523/3 |
Olfactory Neuroepithelioma |
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| 31 |
9500/3 |
Neuroblastomas of the Adrenal Gland ans
Sympathetic Nervous System |
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Pineal Parenchymal Tumors |
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| 32 |
9361/1 |
Pineocytoma |
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| 33 |
9362/3 |
Pineoblastoma |
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| 34 |
9362/3 |
Pineal Parenchymal Tumor of Intermediate
Differentiation |
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Embryonal Tumors |
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| 35 |
9501/3 |
Medulloepithelioma |
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| 36 |
9392/3 |
Ependymoblastoma |
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| 37 |
9470/3 |
Medulloblastoma |
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| (Variant) |
9471/3 |
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Desmoplastic Medulloblastoma |
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| (Variant) |
9474/3 |
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Large Cell Medulloblastoma |
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| (Variant) |
9472/3 |
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Medullomyoblastoma |
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| (Variant) |
9470/3 |
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Melanotic Medulloblastoma |
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| 38 |
9473/3 |
Supratentorial Primitive Neuroectodermal
Tumor
(PNET) |
| (Variant) |
9500/3 |
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Neuroblastoma |
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| (Variant) |
9490/3 |
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Ganglioneuroblastoma |
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| 39 |
9508/3 |
Atypical Teratoid/Rhabdoid Tumor |
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Tumors
of Peripheral Nerves |
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| 40 |
9560/0 |
Schwannoma
(Neurilemmoma, Neurinoma) |
| (Variant) |
9560/0 |
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Cellular |
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| (Variant) |
9560/0 |
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Plexiform |
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| (Variant) |
9560/0 |
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Melanotic |
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| 41 |
9540/0 |
Neurofibroma |
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| (Variant) |
9550/0 |
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Plexiform |
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| 42 |
9571/0 |
Perineurioma |
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| (Variant) |
9571/0 |
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Intraneural Perineurioma |
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| (Variant) |
9571/0 |
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Soft Tissue Perineurioma |
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| 43 |
9540/3 |
Malignant Peripheral Nerve Sheath Tumor
(MPNST) |
| (Variant) |
9540/3 |
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Epithelioid |
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| (Variant) |
9540/3 |
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MPNST with Divergent Mesenchymal and/or
Epithelial Differentiation |
| (Variant) |
9540/3 |
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Melanotic |
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| (Variant) |
9540/3 |
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Melanotic Psammomatous |
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Tumors
of the Meninges |
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Tumors of Meningothelial Cells |
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| 44 |
9530/0 |
Meningioma |
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| (Variant) |
9531/0 |
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Meningothelial |
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| (Variant) |
9532/0 |
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Fibrous (Fibroblastic) |
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| (Variant) |
9537/0 |
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Transitional (Mixed) |
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| (Variant) |
9533/0 |
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Psammomatous |
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| (Variant) |
9534/0 |
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Angiomatous |
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| (Variant) |
9530/0 |
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Microcystic |
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| (Variant) |
9530/0 |
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Secretory |
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| (Variant) |
9530/0 |
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Lymphoplasmacyte-Rich |
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| (Variant) |
9530/0 |
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Metaplastic |
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| (Variant) |
9538/1 |
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Clear Cell |
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| (Variant) |
9538/1 |
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Chordoid |
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| (Variant) |
9539/1 |
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Atypical |
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| (Variant) |
9538/3 |
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Papillary |
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| (Variant) |
9538/3 |
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Rhabdoid |
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| (Variant) |
9530/3 |
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Anaplastic Meningioma |
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Mesenchymal, Non-Meningothelial Tumors |
| 45 |
8850/0 |
Lipoma |
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| 46 |
8861/0 |
Angiolipoma |
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| 47 |
8880/0 |
Hibernoma |
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| 48 |
8850/3 |
Liposarcoma (Intracranial) |
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| 49 |
8815/0 |
Solitary Fibrous Tumor |
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| 50 |
8810/3 |
Fibrosarcoma |
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| 51 |
8830/3 |
Malignant Fibrous Histiocytoma |
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| 52 |
8890/0 |
Leiomyoma |
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| 53 |
8890/3 |
Leiomyosarcoma |
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| 54 |
8900/0 |
Rhabdomyoma |
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| 55 |
8900/3 |
Rhabdomyosarcoma |
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| 56 |
9220/0 |
Chondroma |
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| 57 |
9220/3 |
Chondrosarcoma |
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| 58 |
9180/0 |
Osteoma |
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| 59 |
9180/3 |
Osteosarcoma |
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| 60 |
9210/0 |
Osteochondroma |
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| 61 |
9120/0 |
Haemangioma |
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| 62 |
9133/1 |
Epithelioid Haemangioendothelioma |
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| 63 |
9150/1 |
Haemangiopericytoma |
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| 64 |
9120/3 |
Angiosarcoma |
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| 65 |
9140/3 |
Kaposi Sarcoma |
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Primary Melanocytic Lesions |
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| 66 |
8728/0 |
Diffuse Melanocytosis |
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| 67 |
8728/1 |
Melanocytoma |
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| 68 |
8720/3 |
Malignant Melanoma |
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| 69 |
8728/3 |
Meningeal Melanomatosis |
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Tumors of Uncertain Histogenesis |
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| 70 |
9161/1 |
Haemangioblastoma |
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Lymphomas
and Haemopoietic Neoplasms |
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| 71 |
9590/3 |
Malignant Lymphomas |
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| 72 |
9731/3 |
Plasmacytoma |
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| 73 |
9930/3 |
Granulocytic Sarcoma |
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Germ
Cell Tumors |
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| 74 |
9064/3 |
Germinoma |
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| 75 |
9070/3 |
Embryonal Carcinoma |
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| 76 |
9071/3 |
Yolk Sac Tumor |
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| 77 |
9100/3 |
Choriocarcinoma |
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| 78 |
9080/1 |
Teratoma |
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| (Variant) |
9080/0 |
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Mature |
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| (Variant) |
9080/3 |
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Immature |
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| (Variant) |
9084/3 |
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Teratoma with Malignant Transformation |
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| 79 |
9085/3 |
Mixed Germ Cell Tumors |
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Tumors
of the Sellar Region |
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| 80 |
9350/1 |
Craniopharyngioma |
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| (Variant) |
9351/1 |
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Adamantinomatous |
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| (Variant) |
9352/1 |
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Papillary |
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| 81 |
9582/0 |
Granular Cell Tumor |
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Metastatic
Tumors |
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Notes |
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(*) Morphology code of the
International Classification of Diseases for Oncology (ICD-O) and the
Systematized Nomenclature of Medicine (SNOMED). Behaviour is coded /0 for
benign tumors, /1 for low or uncertain malignant potential or borderline
malignancy, (/2 for in situ lesions) and /3 for malignant tumors. |
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(**) The italicised numbers are
provisional codes proposed for the third edition of ICD-O. They should,
for the most part, be incorporated into the next edition of ICD-O, but
they are subject to change. |
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Updates |
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Brat
DJ, Scheithauer BW, Fuller GN, Tihan T.
Newly Codified Glial Neoplasms of the 2007 WHO Classification of Tumours of
the Central Nervous System: Angiocentric Glioma, Pilomyxoid Astrocytoma and
Pituicytoma.
Brain
Pathol. 2007 Jul;17(3):319-24.
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The 2007 WHO Classification of Tumours of the Central
Nervous System.
Acta
Neuropathol (Berl). 2007 Aug;114(2):97-109. Epub 2007 Jul 6.
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