| World
Health Organization Classification of Tumors of the Central Nervous System
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From:
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) (2007)
World Health Organization Classification of Tumours of the Central Nervous
System.
IARC, Lyon
As cited in:
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK,
Burger PC, Jouvet A, Scheithauer BW, Kleihues P
The
2007 WHO
Classification of Tumours of the Central Nervous System
Acta Neuropathol (2007) 114:97-109
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Contents |
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Tumors
of Neuroepithelial Tissue |
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Astrocytic
Tumors |
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| 1 |
9421/1(*) |
Pilocytic Astrocytoma |
WHO grade I |
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9425/3(**) |
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Pilomyxoid Astrocytoma |
WHO grade II |
| 2 |
9384/1 |
Subependymal Giant Cell Astrocytoma |
WHO grade I |
| 3 |
9424/3 |
Pleomorphic Xanthoastrocytoma |
WHO grade II |
| 4 |
9400/3 |
Diffuse Astrocytoma |
WHO grade II |
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9420/3 |
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Fibrillary Astrocytoma |
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9411/3 |
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Gemistocytic Astrocytoma |
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9410/3 |
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Protoplasmatic Astrocytoma |
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| 5 |
9401/3 |
Anaplastic Astrocytoma |
WHO grade III |
| 6 |
9440/3 |
Glioblastoma |
WHO grade IV |
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9441/3 |
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Giant Cell Glioblastoma |
WHO grade IV |
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9442/3 |
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Gliosarcoma |
WHO grade IV |
| 7 |
9381/3 |
Gliomatosis Cerebri |
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Oligodendroglial
Tumors |
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| 8 |
9450/3 |
Oligodendroglioma |
WHO grade II |
| 9 |
9451/3 |
Anaplastic Oligodendroglioma |
WHO grade III |
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Oligoastrocytic
Tumors |
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| 10 |
9382/3 |
Oligoastrocytoma |
WHO grade II |
| 11 |
9382/3 |
Anaplastic Oligoastrocytoma |
WHO grade III |
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Ependymal
Tumors |
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| 12 |
9383/1 |
Subependymoma |
WHO grade I |
| 13 |
9394/1 |
Myxopapillary Ependymoma |
WHO grade I |
| 14 |
9391/3 |
Ependymoma |
WHO grade II |
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9391/3 |
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Cellurar |
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9393/3 |
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Papillary |
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9391/3 |
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Clear Cell |
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9391/3 |
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Tanycytic |
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| 15 |
9392/3 |
Anaplastic Ependymoma |
WHO grade III |
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Choroid Plexus
Tumors |
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| 16 |
9390/0 |
Choroid Plexus Papilloma |
WHO grade I |
| 17 |
9390/1 |
Atypical Choroid Plexus Papilloma |
WHO grade II |
| 18 |
9390/3 |
Choroid Plexus Carcinoma |
WHO grade III |
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Other
Neuroepithelial Tumors |
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| 19 |
9430/3 |
Astroblastoma |
WHO grade I |
| 20 |
9444/1 |
Chordoid Glioma of the Third Ventricle |
WHO grade II |
| 21 |
9431/1 |
Angiocentric Glioma |
WHO grade I |
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Neuronal and Mixed Neuronal-Glial Tumors |
| 22 |
9493/0 |
Dysplastic Gangliocytoma of Cerebellum
(Lhermitte-Duclos) |
| 23 |
9412/1 |
Desmoplastic Infantile Astrocytoma
/ Ganglioglioma |
WHO grade I |
| 24 |
9413/0 |
Dysembryoplastic Neuroepithelial Tumor |
WHO grade I |
| 25 |
9492/0 |
Gangliocytoma |
WHO grade I |
| 26 |
9505/1 |
Ganglioglioma |
WHO grade I |
| 27 |
9505/3 |
Anaplastic Ganglioglioma |
WHO grade III |
| 28 |
9506/1 |
Central Neurocytoma |
WHO grade II |
| 29 |
9506/1 |
Extraventricular Neurocytoma |
WHO grade II |
| 30 |
9506/1 |
Cerebellar Liponeurocytoma |
WHO grade II |
| 31 |
9509/1 |
Papillary
Glioneuronal Tumor |
WHO grade I |
| 32 |
9509/1 |
Rosette-forming
Glioneuronal T. of the Fouth Ventricle |
WHO grade I |
| 33 |
8680/1 |
Paraganglioma |
WHO grade I |
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Tumors of the
Pineal Region |
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| 34 |
9361/1 |
Pineocytoma |
WHO grade I |
| 35 |
9362/3 |
Pineal Parenchymal T. of Intermediate
Differentiation |
WHO grade II, III |
| 36 |
9362/3 |
Pineoblastoma |
WHO grade IV |
| 37 |
9395/3 |
Papillary Tumor of
the Pineal Region |
WHO grade II, III |
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Embryonal Tumors |
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| 38 |
9470/3 |
Medulloblastoma |
WHO grade IV |
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9471/3 |
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Desmoplastic/Nodular Medulloblastoma |
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9471/3 |
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Medulloblastoma with Extensive
Nodularity |
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9474/3 |
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Anaplastic Medulloblastoma |
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9474/3 |
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Large Cell Medulloblastoma |
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9473/3 |
CNS Primitive Neuroectodermal
Tumor
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WHO grade IV |
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9500/3 |
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CNS Neuroblastoma |
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9490/3 |
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CNS Ganglioneuroblastoma |
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9501/3 |
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Medulloepithelioma |
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9392/3 |
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Ependymoblastoma |
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| 40 |
9508/3 |
Atypical Teratoid/Rhabdoid Tumor |
WHO grade IV |
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Tumors
of Cranial and Paraspinal Nerves |
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| 41 |
9560/0 |
Schwannoma
(Neurilemmoma, Neurinoma) |
WHO grade I |
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9560/0 |
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Cellular |
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9560/0 |
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Plexiform |
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9560/0 |
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Melanotic |
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| 42 |
9540/0 |
Neurofibroma |
WHO grade I |
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9550/0 |
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Plexiform |
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| 43 |
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Perineurioma |
WHO grade I, II, III |
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9571/0 |
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Perineurioma, NOS |
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9571/3 |
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Malignant Perineurioma |
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| 44 |
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Malignant Peripheral Nerve Sheath Tumor
(MPNST) |
WHO grade II, III, IV |
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9540/3 |
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Epithelioid MPNST |
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9540/3 |
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MPNST with Mesenchymal Differentiation |
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9540/3 |
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Melanotic MPNST |
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9540/3 |
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MPNST with Glandular
Differentiation |
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Tumors
of the Meninges |
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Tumors of Meningothelial Cells |
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| 45 |
9530/0 |
Meningioma |
WHO grade I |
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9531/0 |
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Meningothelial |
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9532/0 |
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Fibrous (Fibroblastic) |
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9537/0 |
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Transitional (Mixed) |
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9533/0 |
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Psammomatous |
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9534/0 |
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Angiomatous |
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9530/0 |
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Microcystic |
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9530/0 |
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Secretory |
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9530/0 |
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Lymphoplasmacyte-rich |
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9530/0 |
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Metaplastic |
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9538/1 |
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Chordoid |
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9538/1 |
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Clear Cell |
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9539/1 |
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Atypical |
WHO grade II |
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9538/3 |
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Papillary |
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9538/3 |
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Rhabdoid |
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9530/3 |
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Anaplastic (Malignant) |
WHO grade III |
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Mesenchymal Tumors |
| 46 |
8850/0 |
Lipoma |
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| 47 |
8861/0 |
Angiolipoma |
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| 48 |
8880/0 |
Hibernoma |
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| 49 |
8850/3 |
Liposarcoma |
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| 50 |
8815/0 |
Solitary Fibrous Tumor |
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| 51 |
8810/3 |
Fibrosarcoma |
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| 52 |
8830/3 |
Malignant Fibrous Histiocytoma |
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| 53 |
8890/0 |
Leiomyoma |
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| 54 |
8890/3 |
Leiomyosarcoma |
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| 55 |
8900/0 |
Rhabdomyoma |
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| 56 |
8900/3 |
Rhabdomyosarcoma |
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| 57 |
9220/0 |
Chondroma |
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| 58 |
9220/3 |
Chondrosarcoma |
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| 59 |
9180/0 |
Osteoma |
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| 60 |
9180/3 |
Osteosarcoma |
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| 61 |
9210/0 |
Osteochondroma |
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| 62 |
9120/0 |
Haemangioma |
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| 63 |
9133/1 |
Epithelioid Haemangioendothelioma |
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| 64 |
9150/1 |
Haemangiopericytoma |
WHO grade II |
| 65 |
9150/3 |
Anaplastic Haemangiopericytoma |
WHO grade III |
| 66 |
9120/3 |
Angiosarcoma |
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| 67 |
9140/3 |
Kaposi Sarcoma |
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| 68 |
9364/3 |
Ewing Sarcoma - PNET |
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Primary Melanocytic Lesions |
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| 69 |
8728/0 |
Diffuse Melanocytosis |
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| 70 |
8728/1 |
Melanocytoma |
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| 71 |
8720/3 |
Malignant Melanoma |
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| 72 |
8728/3 |
Meningeal Melanomatosis |
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Other Neoplasms
Related to the Meninges |
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| 73 |
9161/1 |
Haemangioblastoma |
WHO grade I |
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Tumors of the Haematopoietic System |
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| 74 |
9590/3 |
Malignant Lymphomas |
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| 75 |
9731/3 |
Plasmacytoma |
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| 76 |
9930/3 |
Granulocytic Sarcoma |
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Germ
Cell Tumors |
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| 77 |
9064/3 |
Germinoma |
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| 78 |
9070/3 |
Embryonal Carcinoma |
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| 79 |
9071/3 |
Yolk Sac Tumor |
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| 80 |
9100/3 |
Choriocarcinoma |
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| 81 |
9080/1 |
Teratoma |
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9080/0 |
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Mature |
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9080/3 |
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Immature |
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9084/3 |
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Teratoma with Malignant Transformation |
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| 82 |
9085/3 |
Mixed Germ Cell Tumors |
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Tumors
of the Sellar Region |
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| 83 |
9350/1 |
Craniopharyngioma |
WHO grade I |
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9351/1 |
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Adamantinomatous |
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9352/1 |
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Papillary |
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| 84 |
9582/0 |
Granular Cell Tumor |
WHO grade I |
| 85 |
9432/1 |
Pituicytoma |
WHO grade I |
| 86 |
8991/0 |
Spindle Cell
Oncocytoma of the Adenohypophysis |
WHO grade I |
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Metastatic
Tumors |
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Notes |
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(*) Morphology code of the
International Classification of Diseases for Oncology (ICD-O) {614A} and the
Systematized Nomenclature of Medicine (http://snomed.org). Behaviour is coded /0 for
benign tumors, /3 for malignant tumors and /1 for borderline or uncertain
behaviour. |
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(**) The italicised numbers are
provisional codes proposed for the 4th edition of ICD-O. While they are
expected to be incorporated into the next ICD-O edition, they currently
remain subject to change. |
