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Glioblastoma / Treatment / Fotemustine

Clinical Investigations 1

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Contents


Cancer Research


De Rossi A, Rossi L, Laudisi A, Sini V, Toppo L, Marchesi F, Tortorelli G, Leti M, Turriziani M, Aquino A, Bonmassar E, De Vecchis L, Torino F.
Focus on Fotemustine.
J Exp Clin Cancer Res. 2006 Dec;25(4):461-8.
  Abstract |   Reprint |   Related articles

Fischel JL, Barbé V, Berlion M, Formento P, Berrile J, Bizzari JP, Milano G.
Tamoxifen enhances the cytotoxic effects of the nitrosourea fotemustine. Results on human melanoma cell lines.
Eur J Cancer. 1993;29A(16):2269-73.
  Abstract |   Related articles

Fischel JL, Formento P, Etienne MC, Gioanni J, Frenay M, Deloffre P, Bizzari JP, Milano G.
In vitro chemosensitivity testing of Fotemustine (S 10036), a new antitumor nitrosourea.
Cancer Chemother Pharmacol. 1990;25(5):337-41.
  Abstract |   Related articles

Khayat D, Lokiec F, Bizzari JP, Weil M, Meeus L, Sellami M, Rouesse J, Banzet P, Jacquillat C.
Phase I clinical study of the new amino acid-linked nitrosourea, S 10036, administered on a weekly schedule.
Cancer Res. 1987 Dec 15;47(24 Pt 1):6782-5.
  Abstract |   Reprint |   Related articles


Brain Tumors


Hargrave DR, Bouffet E, Gammon J, Tariq N, Grant RM, Baruchel S.
Phase I study of fotemustine in pediatric patients with refractory brain tumors.
Cancer. 2002 Sep 15;95(6):1294-301.
  Abstract |   Reprint |   Related articles

Silvani A, Gaviani P, Lamperti E, Botturi A, Ferrari D, Simonetti G, Salmaggi A.
Lecture: fotemustine in brain tumors.
Neurol Sci. 2011 Oct 7. [Epub ahead of print]
  Abstract |   Reprint |   Related articles


Glioblastoma


Laboratory Investigations


Ilc K, Ferrero JM, Fischel JL, Formento P, Bryce R, Etienne MC, Milano G
Cytotoxic effects of two gamma linoleic salts (lithium gammalinolenate or meglumine gammalinolenate) alone or associated with a nitrosourea: an experimental study on human glioblastoma cell lines
Anticancer Drugs 1999 Apr;10(4):413-7 
  Abstract |   Related articles


Clinical Investigations


Newly Diagnosed Tumors

Altinbas M, Ozkan M, Er O, Everest H, Coskun SH, Menku A, Cihan Y, Kaplan B.
Adjuvant radiotherapy and fotemustine in treatment of anaplastic astrocytoma and glioblastoma multiforme patients.
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 459 
  Abstract

Fazeny-Dorner B, Veitl M, Wenzel C, Rossler K, Ungersbock K, Dieckmann K, Piribauer M, Hainfellner J, Marosi C
Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme
Br J Cancer 2003 Feb 24;88(4):496-501
  Abstract |   Reprint |   Related articles

Gallo C, Buonerba C, Di Lorenzo G, Romeo V, De Placido S, Marinelli A
Can high-dose fotemustine reverse MGMT resistance in glioblastoma multiforme?
J Neurooncol. 2010 Nov;100(2):311-9. Epub 2010 Jun 17.
  Abstract |   Reprint |   Related articles

Recurrent Tumors


Addeo R, Caraglia M, De Santi MS, Montella L, Abbruzzese A, Parlato C, Vincenzi B, Carraturo M, Faiola V, Genovese M, Cennamo G, Del Prete S.
A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma
J Neurooncol. 2011 May;102(3):417-24. Epub 2010 Aug 10. Erratum: 2010 Sep 21.
Dosage error in published abstract; MEDLINE/PubMed abstract corrected. 
  Abstract |   Reprint   Erratum |   Related articles

Addeo R, De Santi MS, Del Prete S, Caraglia M.
Fotemustine and recurrent glioblastoma: possible new opportunities for an old drug.
Cancer Chemother Pharmacol. 2009 Oct;64(5):863-6. Epub 2009 Jul 29
.
  Abstract |   Related articles

Radiotherapy, Cisplatin, Fotemustine, Temozolomide (Recurrent). 
Radiotherapy, Temozolomide (First-diagnosis)

Balducci M, Chiesa S, Diletto B, D'Agostino GR, Mangiola A, Manfrida S, Mantini G, Albanese A, Fiorentino A, Frascino V, De Bari B, Micciche' F, De Rose F, Morganti AG, Anile C, Valentini V.
Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: a feasibility study.
Neuro Oncol. 2011 Oct 12;. [Epub ahead of print]
  Abstract |   Related articles

Brandes AA, Tosoni A, Franceschi E, Blatt V, Santoro A, Faedi M, Amistà P, Gardiman M, Labianca R, Bianchini C, Ermani M, Reni M
Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
Cancer Chemother Pharmacol. 2009 Jan 24;. [Epub ahead of print]
  Abstract
|   Reprint |   Related articles

Fabrini MG, Silvano G, Lolli I, Perrone F, Marsella A, Scotti V, Cionini L
A multi-institutional phase II study on second-line Fotemustine chemotherapy in recurrent glioblastoma
J Neurooncol. 2009 Mar;92(1):79-86. Epub 2008 Nov 19.
  Abstract |   Reprint |   Related articles

Fazeny-Dörner B, Veitl M, Wenzel C, Piribauer M, Rössler K, Dieckmann K, Ungersböck K, Marosi C.
Second-line chemotherapy with dacarbazine and fotemustine in nitrosourea-pretreated patients with recurrent glioblastoma multiforme.
Anticancer Drugs. 2003 Jul;14(6):437-42.
  Abstract |   Related articles

Gaviani P, Salmaggi A, Silvani A.
Combined chemotherapy with temozolomide and fotemustine in recurrent glioblastoma patients.
J Neurooncol. 2011 Jan 13. [Epub ahead of print]
  Abstract |   Reprint |
  Related articles

Paccapelo A, Lolli I, Scoccianti S, Detti B, Silvano G, Fabrini MG, Perrone F, Savio G, Cascinu S.
Efficacy of nitrosourea-based chemotherapy in recurrent malignant glioma according to time to adjuvant temozolomide failure: A pooled analysis.
A
SCO Meeting Abstracts Jun 9, 2011:2060
J
Clin Oncol. 2011 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 29, No 15_suppl (May 20 Supplement), 2011: 2060
  Abstract

Silvani A, Lamperti E, Gaviani P, Eoli M, Fiumani A, Salmaggi A, Falcone C, Filippini G, Botturi A, Boiardi A.
Salvage chemotherapy with procarbazine and fotemustine combination in the treatment of temozolomide treated recurrent glioblastoma patients
J Neurooncol. 2008 Apr;87(2):143-51. Epub 2007 Jun 19. Erratum in: J Neurooncol. 2008 Aug;89(1):119. J Neurooncol. 2008 Apr;87(2):153.
  Abstract |   Reprint |   Related articles

Scoccianti S, Detti B, Sardaro A, Iannalfi A, Meattini I, Leonulli BG, Borghesi S, Martinelli F, Bordi L, Ammannati F, Biti G.
Second-line chemotherapy with fotemustine in temozolomide-pretreated patients with relapsing glioblastoma: a single institution experience.
Anticancer Drugs. 2008 Jul;19(6):613-20.
  Abstract |   Related articles

Soffietti R, Trevisan E, Ruda R, Bertero L, Bosa C, Fabrini MG, Lolli I.
Phase II trial of bevacizumab with fotemustine in recurrent glioblastoma: Final results of a multicenter study of AINO (Italian Association of Neuro-oncology).
ASCO Meeting Abstracts Jun 9, 2011:2027. 
J Clin Oncol.  2011 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 29, No 15_suppl (May 20 Supplement), 2011: 2027
  Abstract


Gliomas


Clinical Investigations


Drug Interactions

Bourg V, Lebrun C, Chichmanian RM, Thomas P, Frenay M
Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity.
Ann Oncol 2001 Feb;12(2):217-9
  Abstract |   Reprint |   Related articles

Pharmacokinetics


Marzolini C, Decosterd LA, Shen F, Gander M, Leyvraz S, Bauer J, Buclin T, Biollaz J, Lejeune F.
Pharmacokinetics of temozolomide in association with fotemustine in malignant melanoma and malignant glioma patients: comparison of oral, intravenous, and hepatic intra-arterial administration.
Cancer Chemother Pharmacol 1998;42(6):433-40
  Abstract |   Erratum |   Related articles

Recurrent Tumors


Boiardi A, Silvani A, Ciusani E, Watson A, Margison G, Berger E, Lucas C, Giroux B
Fotemustine combined with procarbazine in recurrent malignant gliomas: a phase I study with evaluation of lymphocyte 06-alkylguanine-DNA alkyltransferase activity.

J Neurooncol 2001 Apr;52(2):149-56

  Abstract |   Reprint |   Related articles

Fabi A, Metro G, Vidiri A, Lanzetta G, Carosi M, Telera S, Maschio M, Russillo M, Sperduti I, Carapella CM, Cognetti F, Pace A.
Low-dose fotemustine for recurrent malignant glioma: a multicenter phase II study
J Neurooncol. 2010 Mar 30;. [Epub ahead of print]
  Abstract |   Reprint |   Related articles

Fabi A, Metro G, Russillo M, Vidiri A, Carapella CM, Maschio M, Cognetti F, Jandolo B, Mirri MA, Sperduti I, Telera S, Carosi M, Pace A
Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation
BMC Cancer. 2009 Mar 31;9:101
  Abstract |   Reprint |   Related articles

Frenay M, Giroux B, Khoury S, Derlon JM, Namer M.
Phase II study of fotemustine in recurrent supratentorial malignant gliomas.
Eur J Cancer. 1991 Jul;27(7):852-6.
  Abstract |   Related articles

Khayat D, Giroux B, Berille J, Cour V, Gerard B, Sarkany M, Bertrand P, Bizzari JP.
Fotemustine in the treatment of brain primary tumors and metastases.
Cancer Invest. 1994 Jan;12(4):414-20.
  Abstract |   Related articles

Malhaire JP, Lucas B, Simon H, Person H, Dam-Hieu P, Labat JP.
[Fotemustine (Muphoran) in 22 patients with relapses of high-grade cerebral gliomas].
Bull Cancer. 1999 Mar;86(3):289-94. French.
  Abstract |   Full text   Supplemental data |   Related articles

Silvani A, Gaviani P, Lamperti E, Botturi A, Ferrari D, Simonetti G, Salmaggi A.
Lecture: fotemustine in brain tumors.
Neurol Sci. 2011 Oct 7. [Epub ahead of print]
  Abstract |   Related articles

Depletion

Gander M, Leyvraz S, Decosterd L, Bonfanti M, Marzolini C, Shen F, Lienard D, Perey L, Colella G, Biollaz J, Lejeune F, Yarosh D, Belanich M, D'Incalci M.
Sequential administration of temozolomide and fotemustine: depletion of O6-alkyl guanine-DNA transferase in blood lymphocytes and in tumours.
Ann Oncol 1999 Jul;10(7):831-8
  Abstract |   Reprint |   Related articles

 

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