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Clinical Investigations 1

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Contents


Astrocytic Tumors


Alba A. Brandes, Linda Nicolardi, Alicia Tosoni, Marina Gardiman, Paolo Iuzzolino, Claudio Ghimenton, Michele Reni, Antonino Rotilio, Guido Sotti and Mario Ermani
Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma
  Abstract |   Full Text |   Reprint

Marc Frenay, C Lebrun, D Fontaine, V Bourg, A Ramaioli, PY Marcy, F Peyrade, JF Michiels
First-line chemotherapy in non resectable low-grade astrocytomas in adults

38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
2095  

Medical Research Council Brain Tumor Working Party.
Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial.

J Clin Oncol 2001 Jan 15;19(2):509-18
.
  Abstract |   Reprint |   Related articles

Prados MD, Scott C, Sandler H, Buckner JC, Phillips T, Schultz C, Urtasun R, Davis R, Gutin P, Cascino TL, Greenberg HS, Curran WJ Jr
A phase 3 randomized study of radiotherapy plus procarbazine, CCNU, and vincristine (PCV) with or without BUdR for the treatment of anaplastic astrocytoma: a preliminary report of RTOG 9404
Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1109-15 

Michael D. Prados, Charles Scott, Walter J. Curran, Jr, Diana F. Nelson, Steve Leibel, Simon Kramer
Procarbazine, Lomustine, and Vincristine (PCV) Chemotherapy for Anaplastic Astrocytoma: A Retrospective Review of Radiation Therapy Oncology Group Protocols Comparing Survival With Carmustine or PCV Adjuvant Chemotherapy
Journal of Clinical Oncology, Vol 17, No. 11 (November 1), 1999: 3389-3395. (PDF Full Text)


Gliomas (High-Grade)


Brada M, Stenning S, Gabe R, Thompson LC, Levy D, Rampling R, Erridge S, Saran F, Gattamaneni R, Hopkins K, Beall S, Collins VP, Lee SM
Temozolomide Versus Procarbazine, Lomustine, and Vincristine in Recurrent High-Grade Glioma.
J Clin Oncol. 2010 Sep 20;. [Epub ahead of print]
  Abstract |   Reprint |   Related articles

M Brada, DG Thomas, NM Bleehen, JT Roberts, F Senanayake, P Abram, PL Lantos, TH Moss, JW Ironside, JB Whaley, SP Stenning
Medical Research Council (MRC) Randomised Trial of Adjuvant Chemotherapy in High Grade Glioma (HGG)

ASCO Proceedings, 1998 Annual Meeting, Abstract No. 1543 


Chamberlain MC, Jaeckle KA
Medical Research Council adjuvant trial in high-grade gliomas.
J Clin Oncol 2001 Oct 1;19(19):3997-9
.
  Abstract |   Reprint |   Related articles

Levin VA, Hess KR, Choucair A, Flynn PJ, Jaeckle KA, Kyritsis AP, Yung WK, Prados MD, Bruner JM, Ictech S, Gleason MJ, Kim HW
Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas
Clin Cancer Res. 2003 Mar;9(3):981-90  (
PDF Full Text)

Levin VA, Prados MR, Wara WM, Davis RL, Gutin PH, Phillips TL, Lamborn K, Wilson CB
Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas
Int J Radiat Oncol Biol Phys 1995 Apr 30;32(1):75-83 


Levin VA, Silver P, Hannigan J, Wara WM, Gutin PH, Davis RL, Wilson CB
Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report
Int J Radiat Oncol Biol Phys 1990 Feb;18(2):321-4 

A. Pace, A. Pompili, M. Maschio, E. Galie', S. Telera, B. Jandolo, E. Occhipinti, C. M. Carapella
PCV and/or TMZ chemotherapy in 255 gliomas. Analysis of the clinical experience from a neuro-oncology data-base
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1538 

Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, Sabel MC, Koeppen S, Ketter R, Meyermann R, Rapp M, Meisner C, Kortmann RD, Pietsch T, Wiestler OD, Ernemann U, Bamberg M, Reifenberger G, von Deimling A, Weller M
NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide
J Clin Oncol. 2009 Nov 9;. [Epub ahead of print]
  Abstract


Glioblastoma


Boiardi A.
PCV chemotherapy for recurrent glioblastoma multiforme.

Neurology 2001 Jun 26;56(12):1782 
  Abstract |   Reprint |   Related articles

Alba A. Brandes, Mario Ermani, Umberto Basso, Myriam K. Paris, Franco Lumachi, Franco Berti, Pietro Amistà, Marina Gardiman, Paolo Iuzzolino, Sergio Turazzi, Silvio Monfardini
Temozolomide in Patients with Glioblastoma at Second Relapse after First Line Nitrosourea-Procarbazine Failure: A Phase II Study
Oncology, Vol. 63, No. 1, 38-41, August 2002
 Abstract

Kappelle AC, Postma TJ, Taphoorn MJ, Groeneveld GJ, van den Bent MJ, van Groeningen CJ, Zonnenberg BA, Sneeuw KC, Heimans JJ.
PCV chemotherapy for recurrent glioblastoma multiforme.
Neurology 2001 Jan 9;56(1):118-20.

  Abstract |   Reprint |   Related articles

Levin VA, Maor MH, Thall PF, Yung WK, Bruner J, Sawaya R, Kyritsis AP, Leeds N, Woo S, Rodriguez L, et al
Phase II study of accelerated fractionation radiation therapy with carboplatin followed by vincristine chemotherapy for the treatment of glioblastoma multiforme
Int J Radiat Oncol Biol Phys. 1995 Sep 30;33(2):357-64  

Nieder C.
Treatment of newly diagnosed glioblastoma multiforme.
J Clin Oncol. 2002 Jul 15;20(14):3179-80; author reply 3181-2.
  Abstract |   Reprint |   Related articles

Schmidt F, Fischer J, Herrlinger U, Dietz K, Dichgans J, Weller M.
PCV chemotherapy for recurrent glioblastoma.
Neurology. 2006 Feb 28;66(4):587-9.
  Abstract |   Full text |   Related articles

R. Soffietti, A. Costanza, E. Laguzzi, M. Nobile, R. Rudà; 
A phase II study of first-line temozolomide and second-line PCV in recurrent/progressive malignant gliomas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1574 

 

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