Wiley = InterScience :: Article :: HTML Full Text

From: Subject: Wiley InterScience :: Article :: HTML Full Text Date: Fri, 8 Feb 2008 18:34:15 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="multipart/alternative"; boundary="----=_NextPart_000_0059_01C86A81.34F07B40" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: multipart/alternative; boundary="----=_NextPart_001_005A_01C86A81.34F07B40" ------=_NextPart_001_005A_01C86A81.34F07B40 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/96516027/HTMLSTART Wiley = InterScience :: Article :: HTML Full Text ------=_NextPart_001_005A_01C86A81.34F07B40 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/blank.html UNTITLED_PAGE= ------=_NextPart_001_005A_01C86A81.34F07B40-- ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/jpeg; image/spj Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/logo.wiley.526x59.jpg /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAARgAA/+4ADkFkb2JlAGTAAAAAAf/b AIQABAMDAwMDBAMDBAYEAwQGBwUEBAUHCAYGBwYGCAoICQkJCQgKCgwMDAwMCgwMDQ0MDBERERER FBQUFBQUFBQUFAEEBQUIBwgPCgoPFA4ODhQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQU FBQUFBQUFBQUFBQUFBQUFBQU/8AAEQgAOwIOAwERAAIRAQMRAf/EALMAAAICAwEBAQAAAAAAAAAA AAMEAgUBBgcACAkBAAMBAQEBAQEAAAAAAAAAAAABAgMEBQYHCBAAAQIEBAIGBQgIAwYHAQAAAQID ABEEBSExEgZBsVFxIjJCB2GBwcIT0VKC0kOTFBWRoSMzU1RVCLM0FvBicpKyRKJzoyRkNXUYEQAC AgEBBwEGBQUAAwAAAAAAARECAxIhMVGRUhMEBUFhgTKSFHHBQlMG8KGx0SKiMxX/2gAMAwEAAhED EQA/ANg81/NrcPmFeqmkt1W7RbOp1lqhoqda2xUoQuYfqO6VKWUhSUKEmxIAatSlfceF6fXDVN/P /j3L+tp8x5fk91tfp4GjU7NYc33cj41fLHp6Ty+3j6VyRaMUtUZTdcz+cro64UE9unSuQ81R1EhN xfDxGFBPbpwXIZTQvy76+PiMIWinBcgooHp95WfSeiAWinBcj34F6XeVw4mEGinBciJoHpd5XHie EAaKcFyIKoXpy1Kz6T0QBopwXICaF6XeVkOJgDRTguQJVC/j21ceJhh26cFyBqon599efzj0QBop wXICaKo+evh4jDDt04LkDVRVHBxeR8RgDRTpXIgaKpn+8Xn849HXALRTpXIh+Dqf4i+HiPywD7dO lciC6GoUMVryPiPywgVKcFyBrt1TPsuLzy1HohQVppwXIEaKrAxW5w8R+WFBWinBcg34SqkP2rmR 8SvliiO3TpXIA5SVWs/tHP8AmV0RLKVKRuXIEaWq/iucPEYRWinBciSaerKcHXMJ+JXyw9pDx4+l cgTtPWpMw85Kcu+ro64HI1jx9K5ACit4uucPGr5YnaPtY+lciKmawiYfdlj41fLD2i7ePpXJAFs1 s/37ufz1dHXBtDt4+lchZbVd/MO8PGr5YW0fbx9K5IVcbr8ZVD3Hxq+WDbxH28fSuSFnE3Cf+Zez /iK6OuDbxDt4+lckKOC4/wAy9w+0X8sT/wBcSu1i6VyQm6bkJ/8Aun+P2i/lg/64j7WLpryQm6q5 A/5t/P8AiL6OuFNuLH2sXTXkhRxy5/zb/D7VfywptxY+1i6a8kKrcun84/x+1X8sE24sOzh6K8kA W7dJ/wCcfz/ir6OuCbcWHZw9FeSAKeuv85UcPtV/LCm3Fh2cPRXkgSn7r/OVHH7VfD1wTbiw7OHo ryQMv3Sf+cqM/wCKvo64JvxYuzh6K8kCNRdP5x/h9qvj64NV+LDs4eivJA1VF0/najj9qvh64Wq/ Fh2cPRXkiC6q5jOtfGP8VfR1war8WPs4uivJEfxd1l/najIfar4+uFqvxfMOzh6K8kDcrrqhM/xt Rx+1X8sS7X4vmUsGF/oryQuqtuqj2q2oOPF1fR1xGq/F8zVYcPRXkiTdZdUpmK2oE5far+WGrX4v mTbDhf6K8kDer7qcDXVBzP71fyxNr34vmVXBh6K8kBNddR/3tRn/ABV9HXEa78XzNOxh6K8kQFfd pgitqeGTq/lha8nF8x9jD0V5Iy5cbwQR+YVMsftnPrQnkydT5hXx8HRX6ULquN2Sf8/U/fOfLGby ZOp8zVePhf6K8kDVeb2MrlVffufWjN5snU+bLXiYOiv0oAu8Xs53KqPW+59aIebL1PmzReJg6K/S j353ff6nV/fufWg72XqfNi+08f8Abr9KMG+X3+p1f37n1oO9l6nzZX2fj/t1+lGPzy+/1Or+/d+t C72XqfNh9n4/7dfpR788vv8AU6v79z60Hfy9T5sPs/H/AG6/Sj357ff6nV/fufWg7+XqfNh9n4/7 dfpRn89vn9Tq/v3PrQ+/k6nzYfZ+P+3X6UZ/Pb5/U6v79z60V38nU+bF9ng/br9KMi+3v+pVX37n 1offydT5sX2eDor9KJi+3v8AqVV9+59aK7+TqfMn7PB0V+lEhfL1/Uar79z60Us2TqfMn7PB0V+l ExfLz/Uan75z60Us1+p8yfs8HRX6UTF8vH9QqfvnPrRfev1PmS/Dw9FfpRP87u8v/sKn75z5Yfev xfMn7PD0V5I+vqS1zlh82PoWjzNQveLtS2Wqp7ZUNutOVyShisCNTaHFHSJjjI5iOa9o2FVTe0sK LaO562gQxdLoqlr2KgqaqKQyDjUhg4nsg+iM4cbWGpew2AbNdUK0t3OsbNYEFEnSoMKBmfh6pyB6 Ilk6vcWCLDdqd0raq01DClNhTT6ACltAk4UqTmpRkccIlsUos6agcdbSt5gsOK7zSiFFOHSMIWoU E1W0JTqI4Jg1BBY0G3qN6qpKGuL7dTXtqepktNqUnRPAlQQvPPKQGZjz8vlus6Y2Hfi8bVEztF2L FS19UlqncXRsirTQVDlckhLTzgkgqUkSko4ZYQ/u9Kl7dk7Bfay4WzbG0sUeXdQunu1S5X0rLdje cYufxCtJa+Cj4gUcO6sd3pjJ+pVlKHt3Gv8A8+0Nytgn/oZSmnlqr6dDzFr/ADt5hQc1opl4pB7O CiOEX/8AQrO574J+xtx9klVddvt2u22a6O1LTjN6bNQwlAVNCEnSdUxKYPRHRj8pXtZR8phk8Z0r Vz8xY3bYtBZXG6e4bktbVY4mnWaRS3A8luoI0rKdOXamfRHNT1HVuqzov4OnfZAXtg1NNcb5QVtS zTt2JgVFRVrC/guJdl8MNkCZK59npjVefV1q0vm9hm/CsrWTfy+011NsS4NSU4E+yPRVjz2Y/KhK engmCRSBFA2cCJd7PrgkZP8AKgTMJmJ+yCREfyn/AHeCecEgRNpwPZ6ecEhINdkClTlIz6PRBI5A GxrlgAcBzhD1EE2daFGaMCFc4JCTLln1AjTx9kOSZK1dqlgU44c4ReoF+XaZ9ns4zgBs85aUq4YE +yGRqK561ON8MJCRhF6hZVCCCFJ4HGGEgnLUDiBPH2Q4J1CTlqw7vAc4IHrEnrVgezwVzggNYm7a sT2ePsggesRctf8Au8E84UBrFHLXgcOCucGkNYuu1493j7INIdwWVbMuz83nBpDuAF23A9ngrnBp F3ASrd2suPsg0h3BdVvAGIkJJ5wtIaxN6mEiED52PriWi1Ygi2knWoccB6oFQHlPKoglMyMJJ5wa RaxNyjWsk6TkcJemM3U1V4IG3rJ7vHj1QaB91E/wUgABwEPSR3ADlAFEk+mIdDRZQKqRtJ6cevhC 0oruNgVMjAJHRENGisDcpTI4cDEug65BFdOZ5cfZGLodKuLqp/R0Rm6GquAWxLh0xm6GquQDOJEL SN2IKa9kLSUrEC3E6StRHRC0jkxohQOT2mCAk9phwEnpQAZihEgYYjIMUImDBJJnVhFCg+/hTU9H SO1lUoNUzDZdedOSW0AqUcJ5AR9RZwj5lbTXPLazLqayurae+NXuxqKi2wsKL7TxIIUpLg7JlxGc cKfvN7v3QzsVvshf1uEhDTUitRE8SJAD0mPm/Xf5Bg9LxO1/+r/pqt7/ANL3m/i+JbM9mxcTabXY 7Yw02t9n8Q84JpSo9kJBlM9OIyj8gv8Ayvz/ACXqd9GrdWmxJfj8z5n0mPwMNFun8TbWtsWOraSy 9QJbXpkHWU/DEzjIknHrj6LxfU/L2TktPHev/KZNLeHha+VFDfNirt86ijJdpwZuII7ScP1x9n4f rEtUzbH1eyfy/wAHj+T6c6LVTajVKmg/YKkMZJ5x9A7HkpE7ZXV1LdaF5lp6qcokNVVscDvwmmyy 0lmqaePzCE6tAzwjws9d/v3/AJHvePbd/b8zX7s+Ljabp+XN1VNQVSkllNQsqccrFPB51yfiSkJC UnolGuOrlTv/ACMsl1Djd+ZtlFfdnXdiga3CXE3Le9Km3bg0uBDbTlpSSh5Q4KdOkTjz7UvV7P07 viehS9LLb+rf8Cgsde/ebh5h3h9QbRWWeopqFtagmTbckNITOUzpTkI6b001ovec1L6rXfuJXTbd detjbPfpX6ZKbZbnjWJdqG0upK3NaRonqJIyEXizKl7T7WRlwu9KxGxFn5kWu5XylccZatBsjVDR r/HhbRuRdZQApuYJURMylKMvFaVvbM/A18pN19kR8SsvdTeLnsHaVBUvpWVqeTXqTpLriKQ6aUOk Y4JKpTjq8eiWaxzeRkbw1/r8ATdqDaUplkfdj3VY8Fog7bgGiZeFPOHqCCvNuHzeCucPUEHhQFKu zhj7IeoIJJplACaQcE84WoUDItwUjVpzCj+uDUKDyrckKkZCZwn1Qaggh+WggEDgnnBqCCCrYJHD grnBqFANVsxy4+yHqCBdVrBHd4J5wahQLuWlJB7AyVw9MPUAFdqAMgmQnw6oqRCjlqBEimYknD1w SITdtCJHsDJXD0w5CRZy1AGQTLtdHoipEJOWsEd3gnnDkUiL1rEj2eCucMUiTtrGru+L2QxSV71u QgDVIYJz64Y5K96laAMgT3sh6YA2i5oHFqwaknVmcOHVDE2AXbcMuCecBOoXctuBw4K5wQLUJu0r SFyOergJ8IYSxRdOwQJieCcx6Yke0gq2oKdQQMQo5Y5w4FrYNdCASSMAc/owQLUIqbbAwSck84k0 2gHGxIyRwVzhDRFFMpxRJTJIP65Q4E7QDepNDZVLGSZdc4TQ1aWV66UmeZwVzjNo3VgK6THLj7IW krWB/CYjD5vOJ0l6ybtJ2VYcFQ3UiuTaVrlJjlx9kYup1K4qul9HRGboarILrpvR0xm6GyuANPJW XH2ROkvWQVTno6ITqNXAqp88OmIdTRXBKZx/26IWkpWBlv2RGkvURKPbCgqTBRCgckdMv1QoHJgi CBngIYpMygA8IYEp4QCP0qFsYepHWaloOUzjWh5oiYUhQIUJekYR9Jdny6Rz/wAornsBy919t27T 1VDcqwKKGqxYWlbbRJ0ollIYyVjHnZctcdHZ7kpOt1s4R9A/A/ZPU7CJlt1oaAMcEFM/WY/lz1fz snqPkZcj2t3rC4VhpH2ODEsVFVFrRrbQwgMhLtTTgpeVmEpJJmkcZEyJjTxbVrRKv/VqbH+Hu/Nm xslDVpW2H3lydHZSpRmFEcT1R9b4udWWqz2/5EOO1obb+IVglQ0FIM545/ojuv5Omsz7gNJuVA2m qdSgdgkS/TH3no/mvPg2uXRw/wAv7HzPmYVTJs3M1K6sUluck5c27ep8KIQ4+lnXI9CiJx61qK3s MKXddw9T2UrIcqVqfUcAtR1YaeHoh1qq7ibWdhV7Z9uecDymhq7JnL0xUIWpmKjadI6jRokJK/UY GkJWaKg7MtDlaujQ+2axsBxymCwXEoUMFFE5gHphaEVrYel2NS0ytaeITP8ATDVUhO7ZYU+22Kdw upGMlc4tbDNuSy/ByVgOMv8AwxeoiBeppAGZSz0D9cUrC0mjeYG8LXsCy/mle2p+oeUpmipEEJU6 7niTkkDFRi05BVk5q35u7+apG7/XbLV/pxyTn4lr4oPwz4gsgiUuJSBF7C9COz2pxF2tlJckMO06 Kppt5LFQnQ6gLxkpPAxEmbqXLNICynDgvnEOwoKzc7n5NZq27hg1H4Fpx/4KTIr+G2VaQZHOXRFK w1U03y63mrflDW1n5au2GjdbZ0LWV69Q1TB0pim4HakG6FhwA9o5Kzx4wtREEkNEuALxBVKcvRBI tIQ0IkMOCecGoWkr32VNlSVNjAKx9E4pMWkXWntYt+Lp9EVItIqtAkP2fBPH0w5FpImkQ4gqSOCp j1w5JgUqaBxOLSQZKxBz7sUrEwU7rTpGQBknh6fTFJhBWOp+IpxCHQpaNWtKSJpmeIGUVIQQFK+p Ui3rGrPLwxUkNAnbcCkakzwRhL0w0yBBy1NJBKUAGS+cVIpAO28au74vdipIK6ppg0kdgqMkZDDP pgke8pqlpxwKBwTJfZGHGApJITXRdqQHi92AJMtWiQC3U4yQQn18YaRna5J2jASokSAC+cMzkqap v4iylI/Z6v04QM1qoQgaTAYcE84mCpBKo5zAGernBAahtNAGwEgY6sevTFQYO0lfWU4JSgDIJJ6y YlmtGIrpcDhwVziYNVYEqlxy4+yCA1AU0k1pEvm84SQ3cK9SdhRl4Vw2jOttpVLpccuPsjJ1OpXF V0mGXARGk0VxZykwOHAxLqaq4sulM8Bx9kQ6mqyEVUnZBlmBC0h3BdylPR0xLqaLILrp5HLj7Ih1 NVcWWx7IzdTVXAqZ9sS6misDLePr9kS0WrAyj2RMFyRKfbEwOTGmCByYlBASelAM9KAD9TqWmwT1 I5x7d7HzaRqO76bavlzTP7+p7A3UXcOfDCmv2fbdVIqUQCEzGZCZx5fm4H5GG+JW066us8JUSdWN xZPfBZ+W/m9Z99O17aKNy33cICnqJTgdSaZRktbbgCZqBKc0iU+Mfgvrn8eyejN5Z7mPI9MrY67J eyXt2f8ALn2PcfT+P5azOIhm+sM1FPUtGnXNC8W3093SM59EhmI+SxY748i0PY91vZH9b0dpai50 zygO00hA0oKACkjp0kiRPXHt18/HZ9KXD/XvEMLq6dFO2VuFc1qUlAEpgADEk4Yx2W8qiom3O1iF gV1INSvxqw9R4eiPvP4je18eS73OyPH8/a0fLP8AdcgJ3BtXDNl//GTH6Pg3M8po6P5reYm5tiWa jb21YnK11yjFU/dnUFVHSttpSg6tMpqmoYKIz4xnSqs9rBo5nY91+e1x2bUeZ1De6attVE47+KtD rDQIZpz21AJQmYTnguco1aonpFB2bYu/anzF2I7f7DSsNbhbDtO5RVC1CnRVpkRNSQVaCFBWU+EY 2Wlwwg4H5NL8wb75nXitobmwa9LqVbgeqRr+NTIqAlaGppMspJykI3yQqhB1Pza82Ltt290Ww9kU iK3d1eGtTixrSyXj2EhOAKyO1NRkkYmM6VlS9woNQvW6PPLyqFFf95VNJfLDVuBmqYbDc2lqmSjU 222UqIB0ntJi0q22IIOpb736qxeXbPmBYUJqGHF0VQhp0SDlPUqQFIMsjpVKfAxlVTaBQcme3t56 70YO79n25FLtZLvw6GgCWXXHkoVoKla+0uR7xTpHRlGyVVse8IRtPnD5ebk3vsy2Oshpzc1q1P1F GxMNPKcSA6lorOYImmecKt0mJbDRtj+e723W6bam/wC2OsihSmlVWJQUvIS2nQkPMqAJkBIlP6It 0nagdTuly3TYrbtR7eIqE1Nkap01LbzB1fESTJKU+kqOnHjnGS3wTBx/b9/88vNFupvW06iksNgZ WtFMhwIPxFCRKdS23FKI4qkkRdtNd5UI6Za6rzCpthX2s3vT0tNuC3NVK6R6mKVodSwwVpdUkEpx Iy/UIzlTsFBq3kbvG+bzsl2r9xPturo6htttaG0MhLejUZ6ABGl1ArVNWd8w9/8AmTuKtsvlmGbf Z6An4t0fCVFSNRAWStKgAuXZSEzlxioSW0elIsNo7/3hY97teXvmOlp6rqiPwVzaCU6lLSSiegBK krlpB0gg5wmlEoTqo2BfNzzW3ftR5y2WG0qpqZkModvlUjW2tbqVKSGR3eBxVPEHCCtUwVUa5V7k 839qbdtW/brcKa+7duKG1u0ym0NraD+KQShCCJ5TExPhFKG4HpTOjXPf1motit77CFLo320Lp6Yk BxTzg0hufSFTBPonC9sGWjbBzWz1nnVvik/1HaKmltlsWT+DpVpQA6EKIw1IWoiYlqJE4uUi2qo6 DRXa+2LZ7+4N807dJW0SHVVCaY6kqSFBKOJGpZOABhSZOqb2HPbZfPN/zGS/ettOU1msza1IpkL0 ftFpGKdS0LKj0mQTFTBTrWu8tdibuuO7VXXa1+aTR7st6FIS+2NKVFCi2SUiclIUROWcOSL0S2rc WNg2xW0Ny+M/SKbSS6talESaTpUnQFalFzUSkzwy6YckWco2x2kGrLxe7FpnO0Vr7DTaQVkDBGHH OKTJgqapxICg2meC+0rripDSIqW4FdtAUNXV4YuSXUCVsKACgUmSM8ePohyQ6i7lHTPBRCUrMlzl nnDJ2oXNsZbcKkokdXHHwwyW2AXSCQw4I5w0ySsraCocCkpA+HJchPE48YBppFc7bH0rxbPe4SPh hlakJqoHABNs5I4HphBJligJKnFpwSFy65wyLWDPMBsKWRgFfr0wzNbSjXT6u0cyEk/piTeQK6bA 4cFc4QSCVSkqy8Xuwwkg1RkuIOkykkzlCSFa2wm/SEtrCRMkLAHrimiK22leq2Ok4gDH3YnSa9xC 6rXgNR4JyHpidJXdArtqADMEmSs+uE6lLKwC6IA4Jlj7INI1kFHKTDLgOcRpNVkE3aTA4cDziHU2 WQUcpZHLj7Ih1Na5BNynkMuiM3U3VxRxjPDpiHU3rcXWzj6/ZGbRqrAFN+yIg0Vgake2JaLTIlGc KCpIlMKByY0wQOTGmFASfq7StjSnqRzj07s8JIaqrZQ3Sift9wYRU0VQhxDzLg1JUkniI5bM2SNF rdq7W8rrVer9tWzL/ME06VDW848JJM1CSyZJxmZYx+Peofdef6nT03zckYrWmtlVKdj+Db3Lgz15 phwPNjU2Sjb7Jan4e0o/LjzxO4LorbtzoW6aoruzTupmWllIJLakEnSTLBQPojX13+I19N8a+Xxb WvVfPXJE6fbEf1A/E9QveyrkS2+2u4662mmfcShCHGnFkAJTJYmeicjH5nRY8jSSab+J7Y2RTOOo ZYDlR8IaEJEkJJnMqJxwJjvSpe6pRO8bEt0+/wCJLLFLak4KIJ7PdwSJHIeiP3D0bwX4njqlvme1 xu/BfgeB5GTXefYfKv8AdoANw7T/APJqP8ZEfT+PuZyWOv8AnIkDyYvx/wDgs/8AU1GGP50NrYc7 8qQP/wCatynop7tP7oxrk/8AYhLcN/2lpCtl3z/9FX+A1C8jegqax/bepNN5qbwoKg/DqlIqAlpW CiWqrtD1Ti83yoSKjz521+RebNJui+oqv9J3f8Op2roToeb+E2llxCVykFgJ1gcRFYrTWFvBhbpb f7d00jRd3debil9SQmlaW46sFRwKkraAEszMz6ISeTgLYdH85bHbtt+QblltTrj1tozQopXXjqWp svIUkkyHT0Rnjc3G0bL5BNpX5R7c1AEaH88f+8eicr/6YJFv5ib4sXlzaGbveKWoqGah78OhFIjU RqM1KUSQkADpOOQhUTs4FBxXzg8wfJjeezqh2keVV7nkn8r007jdS05hg4taQNA8Q1H0RvSt0xQT 2jsHct5/tyuFtDazcKxxdfaaNQktTCHELCQD88oWpPTMdMK10rhBLyL81tm7Y2irbO6a02i5291+ aX2l6XEuL1YFIMlAkgpIEPLRtygg6m9vfbW/dg7suG2qhVTS0dNW0zq1oU0daaVSgQFSOkg4GMdL rZSEHK/7ZLYq67M3TRpWEfHqEsauI+Ixpn+uNsrhoUHLNp7f23t/dF22t5m11dYX2DoYqqVa22VL bJHb0pJKVjFCpSjVttShnSto7U8mLzvu30O39wXS53ylP4ymfWVKpyaY69GtaAZ8ej0zjN2sltQi 8/ugpQxsi2qCpk17Y/8ASchYnLElBX7+SB/bXZVdNPbv+tMOvzh7Srq9p1+5f7crOq1NKeraBZrS wgFS3G2lupWEgZkBWqXoitUWF7S48rvN7YtBsm32m+1qbZc7U0mmeacbWfiBtRktBSkzmMxnOC1X JLqbBu12j82PK66ubPcVU/E1FhCkltanKR5LhQUqxBUB2esQlse0lKGcJ2FTeXT9sco94Xm42S80 rqw4ylxbbCkHLSEoVJQOCgY1cmlp9h0nyvs3lsb3XXraVwrquto0hh9VXPQ4HyCVpmkEiaeMG0yv MbTq620rQVJxTJzH1wHPBX1tG8tRLS5dru5eHpi0yYNefplJMlpkqSM+uLTFAi9TiSsOC+cVJMCj lP28vF7sXJLQJu2LeAURpRJGPTjwgklhjQttIKUJlg5M8TjDkyYrVIbZJK89WCRmexFSTBSreezA GkhEky9MMekAt9QB1Ng4Lyw4wydJBT7ZXigjtYyx8MMjQCSWndKUg6iEcPTAJ1gw5T4HqXzhkCzi GgspUoAhWR/4YYQKqbYkO0nJHEdMIIYu4hmR7Scl8R0wwhglhkK7w73uwChi4bQ53TOQRP8ATADU AnKbA4cF84CZArpu1l4vdhhIqqmwGHBPOEORZymwOHBXOENWF3KXtHDxe7BBSsJuUuGI4J5xMGiu JPUsgcOCucS0a1uJPUuJw4+yJaNVcQdpsMuA5xm0dCuIPMYH184zdTorcTcZkThx9kZupvWwotr2 Rm0bqwBSPbENGiZEozhQVIMohQVJgpiYKkxpggcn6u0wwT1I5x2WPHqWLeCT1L5xzWNkHXTsVH7O oQHEFUlJPEacQfQY8T1P0rB59FXKttXKa2NP3M6cWV43sNVovLrbtrvAv1utVMi46i4hwJklCnJg lKD2QZEiYj4r1LwvX8mN4O8s2J8dKb/GVt+o6cFfFpfWq6bfGPgt39jbEMqZQfh07JeWFBxztBKU 5EJGqc/THz2H+L+ctnbom971bEvdDb+Ow9N+ZjXtGadotSSZAAy0oGlOU+s+uPufSP49j8OLXatf 3KKr/f4s8/N5TvsWxBgcB1I5x9WcRS3zaW19yuMv3+0UtyepkuCnXVNJdUgFQJ0lQMsYpWa3AWFw tdtutC7ablStVVsek27SPJC2lICQQCk4SwhJwAnQ7Z27brO7YaC2U1NZahJS/QNNpSwsPYLCkASO oZw5bcgZsu3LBtqmdpNv22ntlM6pbjrVK2lpKl4J1EJAmZACBtveBKg25YbZdK68W+3sU90ubgXX 1baAHXVJRIalf7Y4wNt7BB7jbLbeKJdBdaVqtoXUoDlPUIS42rHilQIgTgDXLX5X+Xljq/zC17co aetTrUh4MhSkmfh1T0+qKd7P2ig2C7Wa036jXbL1Rs19vdWkuU1QgONqKBqSSk4YETiU2twHrXar bZaBm22mlaorewE/BpmEhttGpZUZJGAmSTA3IBqukpq2ndpaxlFRTOpWlxl1IWhQJyKVTBgA1On8 pfLWkrxcKfa9vRVJWFJV8FJSCBOYQZpGPoi9duIoNvSlKUpSkAJAQABgAAYgDVr55bbD3FVm4Xrb 9FV1x1FVQtoBxRBw1KTIq9cWr2W5hBcUe3bFbrcuzUFupqa0uBTTlGy0lDSkLRJQKQADMHGJlgCs e2dv7aYcp9v22ntrDxbcebpW0tJUsYAkJlMyhuze8BbcWzdqbpQkbitNLcS0F/DW+2lS04+FeCh+ mGrNbhGbFtPa21kqa2/a6S2pUrtmnbShSuzxVmfWYbbe8Rm9WPb24aVujv1FT3GlbKHEM1KEupC8 RMAzxkYE2twC9ZYts1loRYKq3071laTpaoFtBTCQ2RokkiQ08IpTvEOW+1W6z0jVutVM3R0DBIZp 2UhDaARMgAYDEwSS0ahe/LjY1xqxcq7blC/VK0KW8WgCpROJWEyCp+mNK2YmP09OxbqVNHbmGqOk bSsNsU6EtISJ8AkCLIZrd62LtK+1hrbvZ6aqrCrtPrQAtUk+IiRPri0xS0MUVot1ppU0lspGqOmS ESaYQG0zn0ACKkh7SSviNalIMsF9WcMkKmobWuTg0K158O7FENAXqZt1ACkhQ0ty/TDTJaKertRk otGYk52T1xckg02tttc3O2vXlwHYipIZBbA0jDwt84aZDRU1ryG0qQ32lycE+AxihaSmebWt0qXi orx/5IoIElMdkYcG+cMQs6zgcOC+cMmAC2O3l4vdhiGqai+E2FKHbUGz1CeUBlYHVgMtKV4iHAke mcBKUlKtklZJxJXifowyxcs4DqRzhAAcZwOHBfOGIEpjtZeL3YYglLTgNlUs9A/QYEZ33knGMDhw XzhmYFbHa+l7sMQqpjAYcEc4AAOMCR6l84AkAtjtZeL3YBSKLpxLLgnnCLkTepsDhwVzhNFKwk9T do4cfZCaNVYrXqfDLgnnGcHRWxW1DEp9SozaOitiveZx9fsiGjprYQcb9kZtHSrC62/bENGqYIox MTBckFIiYKTIaIUFSY0QoHJ+rFP3U9TfON7HmofbyPU5zjCxqhtPe+l7sYstBUd0dSOcQUT4HqXz iRk/F9L3YQzwyHUjnAM8cj1L5whGfF9L3YYzAyHUjnAB45HqXzgEZ8X0vdgAiMh1I5wAeOR6l84A M+L6XuwCMDIdSOcAHjkepfOADPi+l7sAERkOpHOADxyPUvnABLxfS92GITq/3SfoczFITEFZHPJf OLEYPe+l7sAgfAdSOcMCCsj1L5wxFgz3E597xZ92JAC9+5Pd7qO9lnFITKNzJXUvnGpABff+n7sU iWKKyHUjnFIQo7krLJznFECznf8Ap+7FoklST0jvykic5aM/0wEsk93VZd1znDJF3O+cu/7kWZlV Wz+D4paW56JSz48YpCKB3JWWTnOKAXX3+Hf9yKIYmrIZZN84BMVcyVlk5zhiMNS/Eo7n7zxTl3YZ D3Dishlk3zgM2VNy7w/4XJTy73CGOpXr7/Dve7AAue6OpHOEDAOZHLJfOGIEqWvh3vT82GSMMS+A ju5J6fnQ0ZW3kXMjlkvnDIAr73Dve7DELKyGWSOcIGAcyOWS+cMQBfe4d73YCRVcpDLJHT0wihV3 I5ZK5wFIRe7xy73uwi0Vr+XDJPOJNqlXUccvFzjNnVUrXszln7IhnTUr3fkjNnTUVXlw4xDNkBVx iS0QMSUQMIoxCGf/2Q== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/dot.069.gif R0lGODlhAQABAIAAAABmmQAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/auxnav.gif R0lGODlhwQBXAOYAAE2UtjmGrM/l/HuvzRRxnZfA3LXU7mGYtv+ZAGudv4+30VKQtYyyztTm+LjT 6FiRs12avSZul9Tm91SJrcHZ7bfR50WDqsje8Zq+2E2LsM7j9XOgvzl5oVCIrix1nzNxmkR9o2eb u67K4YOuy6/N487i9HalxD2BqDh6oWOUtsDX7KPD25G51NTn+KXG3bnU6YCpx8fd8FyWuFGWt1aZ uUOOsWajwFqcu0mRtD6KrzSDqmCfvi9+pih5oRpplRRhjSFxmw1WhAlOfQAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAADBAFcAAAf/gASCg4SFhoeIiYqLjI2Oj5CRkpODQkJBQZaam5ydnp+goaKjpKWm p6ipqpuZmZauq7Gys7S1tquusLe7vL2+v6Ctl7mausDHyMnKr5evrcTGnNGd08HL19ilusKYzN7N rN/hp8ShsNXS2eK05ejFps/d8sLgzdDv3PX03vL86fn23n07V6+gQYHlhlEjZQxgwHUHIWKaOIzi PIXFGuID16+iuGj39AkMmI/gxnvT9vljlsvhSnop/+krObFmTYU3LcbzaJMlyXhAeeJsubOkvW44 WVpUerFfSJgPmzJ1yhHjzoo2s2rdOi+nVaBNdTrDyo0i1qE8qfYs6rRr2KxH/+Ou9fkWLMmHP7gG yau3b1eyYP3CLSu4sLPChgPrVJyz7dCtR/diystXMuLLfStXrqkZs9bNnkNv7Sx6ImjBlCerloyA c5AJGzAx+IAJhAgRIDBNYJA7CAwGuhkIj7269GfXpFOfNo7a8+bUq5Wj/kGdMl++CFpbZ+Agb4MJ QSJoEF4iQhAGElYEQdFAQl4GMRgoiE1d8nXV0i3nx6/fsmn+9mlW33WkmQZddPndd6B9/YGmIH4F VifhhNlptxcDFewlwQNBpKDBXiWk8IMCElwQxAbtYaJABdBVh+B/L/I3YID9/ddZiw8yuFeLNupX n489zmhdjQAySGCAE1JYYf91DFygAAPfjchiEA4w8AMDFDTwgQsqNLCXAhRM8MAHQg5pnZnK/Sjh jgOiuaaLbZq5o5FzppkmjWUSGCeabMLZJptIJinhktUp4KQCDXCogAN7OaBAECtSYMIFGHg5ogYO VGCCoEn2KaingJ5Z55ujejrhqHbuaSqnoMIZ6plloronp9Rl1+ai1CU6Ync/OLorBg40EIJ7u8JK 65vH9qnsp8Ye6yyrpz4brZ+z5intjj784EO21XGLQJK4/qDrAw1EEIGui4bQAAXkUheutPDGK++8 9NZr77zcZpuvvhMumm2i2VJAAgkUZLvouRg80AJ1LGjwggMYULettt1SbDH/txTnW/GEGHd8ccZJ eiwxx4JqjLG2/I6s8cgkswwyyCezrO/E2+47M78+oJABdQ94kG0EI4zg8w8n7JxBBB48oO0JD8jw wM4Spxz1zCjLvHHVIousssUwc00zzi5LSLPVH5tcc8Ydeyx1yl/X7LbNWLuN9tltU2132XJ3ffPE UaPtNcx0720yymPX7Xfhb8d9c9Vb57343odnS8DbcttdeeCUC044znQTrnjnl2PeNuCiJ/644INX Prfno3POOeuhs0745EBkbnvmpM9tuu6lb2447rfXTbnvtvMePOrDAx888cf7UPvzzk++7eTS11z7 ttdj7/zb2d/e/fHXh2/7//fNk7+9+ds3Xz7l0KvvfubZQ99++u0DUfsBB2yLv/0H7KB//kDYnw/w 5zwBEjCAADwgAQd4gPs1kIH/+x//HmhACibQghGEIAIdyEEGOjCDFYwgAkVoPeehj37x014K5Rc+ 8dXvfOk7nwtj+EL6wRB78kNhDnEIwxa+8HlAjKEJS0hDHrIQhy284fxyuMMgspCJTrSfFKNoPxNW UYZS7OEThyhDKw4RilrkohNteMUq1hCIZhSjCrNYxjF2MYna66EQf/jFI6KRjWbMIxXTyMcpYvGN cGQjINP4RRXW0Yo+9GMb5chHI45xilmM4xYVScknNhKSmMykHjdZSU1mEv+Rn/TkHSkJyj52spSI LGUn7ShKUWLRlZB8JRB6MEsp0lKKCMikDgQgAPsNgJcGGID9alAAARTAAkBIQC+BIIAEAKGYvBTA AqT4S/s105cCMAAyW8nNbnrzm+AMpzi/eUv70TI75qylDXgJACCscwHrhMAzg1kAAwDhl7QUgDAT sE4DJACZtKxmD/QJhAU00wD2FOUty1nLcdrSoVNkaDohudBaSrSVF+VmDza60YaWswcVouUtC1DP BPRAmUCYgQDk2cwerNOdAsinMGUqUvutM5/OhIAAOmCBmlr0pw396UeB+tCKDnWiHLWoT4O61IU2 FagdralPK/pQTD5VqBz/BWlIZ9kDehqgB7/kZQFmqU+w9rKazByASAlqS4ESlAcGKKtQudpUqnK1 qHS1pVTnylCjKnWuRJVqVCnq0b0K9q6IFWlWF6vUrW40AALYAUp/OYNf1mCgJsWnMjcqABvUsqVZ RWtLZ/lLtQ7WqYrN61T/ytis3lWxsM3ra82Z1Nq+dqqpPa1f6Qpbw952scDNzmJ1Gk0c4HOgNhio Wqt53M5ylKCKvSlye2CBzMa0tlEFLnZ/i13tuja7vM3tdwXb3daCd7zeRW9505tVBAB3AMH8pQ0o +0scdNUANkBoDzpgzGLal7Om5SgO+isA+yozAfVkr4IXzOAGr9fBENZu/3ghzAPgVvjCizVAASqs 4bCWtQc4KGYBOrBR+AYzqx+ucIkRGuBfGmAGKnZwjDk648XWeMY1pnGEN5pjHdu4ByrGcHp77F0e GBnIPBaykHnM5BgHGclGxvCFn+xjKFs4q0fGspWpvGUdL7nJYFZylZ/sZC+PGclgRrOUraxlJts4 ylEG8pSPDGc5Q5nOeFZynOls5zXDOctSnnOSB11nP2+50Hc+tJynnOQ193nRf270nucc6EgLOs+Q /jOl+WxpTXM605e+dJ893WlQk7rTnNb0qEV96lYnOs+FJjWk74zoVtva0zq4ta53zete+xrOuSZ1 sH9N7GIL28jD5kGyh/9tAxsYudnPdjYPbJAAZSdgAMqmtpEHkIBcc9vI17Y2tnkQ7mlLewDnlra2 yY1tHTTb2+2GNg+4nWt5h1sH/AT3uOUtb3Q/e9/q3jfAo71tZ+O73VHOdbL/vHBb60DhClf2w4f9 cIkr++LIZjjGK27xi0c84hr3eMZFDvKSA3vjHv84yVPecZBj/OUs3zjFNe7yYHPc5SePuc1JXvKK Q1zmEp/4yh/OgZp3POUml/nMIT7xjzM94TxvObB9vnKJF13oPv+5zYs+dJbbXOVa1zrSsR70ppvd 7BY/O9PBPna0u/3pao872Zve9qzbHdl0n7vayy53p6/d7nFPe97jHoD/iRe+74hPvOIXz/jGO17x h+975HUweblX/vFqr3zhL//wyUd+852nfOhFP3rSi57zoD+86ju/+c+TXvNnT73hmx6A1Z+e8KWn /et1P3vOxz73owc97YWfegSEvvA0EDENCg9ffRY+m7XX5w6iacwADFgAlA+AiQegg+lHswCg/+XD nb+DuL649bdHP/pfX/vs9571u5f97eEvf+Kvv/XCT//xbX//7Nf+/wBYe9nxf5THYggVADRAYMvH SwMAWQMAAM03ANwXVjuAgAoIgXElga33S9HHfcZUfgbgf6nXfgFIgCaIfyhYgiq4gisogifIgvRH ginofgGYfTkQADeI/4O1l4MBUCE6CFngNwBBKAAdCFnQV305wIG1R1LBpH1EGAAGUIFOqIM5qITO V30zUAM8+H9buIM/WII32IVeOIYsWIYq2IViGIY7KIZcGIBs+IVq+IM5cIMVggA66Hw7yIE5cIUZ qE83qIRQKIQGEADFVIK/FIeESIR7OIT4FYeImIOO2IaS+IhjqIZhCIlyCIeZGImY2IZzSIWXmIlU SIZeGIqQmAMVModz6IefeIgOuIjQBH45UEw3CACdVU9JKACqiIO5uItzqIesuAAitoZyaIqlCIqj 6Im8uIyWyIu+eIy++Iyq2IyWeIqa+InYWI3TuI3cmB3b6IeHeIh7OP8A47hOrCiO5shLNyCO56iL 28iOA2BcMzCL7siN9niP+JiP+riP/HiPztiPAHmPCMCNBmgAOXADxhRXOzCO9EiO9DiH9SSExoSQ JCUANwCR9aiKFFlMELCH+IVQARmSIjmSJFmS26iFOYCS06iS03gD5ncDWmhiBbCKM1laKXmINaBh c6iT25eSuciSN5mBc+iS2bSQJ+mTKcmSWgiUR7mUSumTTKmKUYmU9jiVU3mUUsmNKrmUc4iSXOmV UNmVYfmUXfmUWwmUZlmWY5mUahmWbkmVVPmVXxmXYLmVSAmWYumVdgmXUsmVKymWbumXc9mXTpmU NXCYiGmYTnmYign/lYj5mJCpmIkZmZA5l5T5mJJZmY7ZmIbJlpNZmXL5mYWpmYxZmonpmZeZmaWZ mawJmq4pmqopmq/5mrE5m6BZm4tpm7q5m7xJmqOpmo7Zm4+JAzVAnIdpnMNZAxJ4mMupnANQnM0Z nfHonND5nNR5ndLJnNaZndi5nd6pncTJnRIYnt5Jntp5nt2JnuL5ncJZnO6JnK9JnPL5nu+JA/ZZ n8g5n/e5n8fZn8apn/9pn/w5n8UpoAVaoANKoANKn/upnwwqnwpKoO6JnxOqoBV6oRD6oBnqn/7p oAkqoAa6oAAaogmKnyDaoCSKoAF6nwcKoS5aoSKKoC1KoiGqoSd6/6ImOqIymqIl6qEPCqMZeqNC OqREWqRGeqRImqRKuqRM2qRO6qQAYJ9RigNROqUgaqVJOqVWugBSKqBV2qUAYKVfSqUnyqVaaqRY eqJpSqZq2qVkiqVVOqZwCqZsSqRhWqdX2qZfOqd02qcLEKd4+qZryqZyyqVsyqWGGqV/KqALsKhC OqZ4qqhXmqaQmqeMuqdemqmCmqdh6qiYigN/aqaP2qaG+qamKqZumqlxGqasyqpU2qqueqewKquw eqqzuqq3mqu6Wqu72qu4uqe9+qqxuqvC6qu5WqyziqzA6qsIMKu/FKb6ZIvRBK0FwKphhV/Gmq3a uq3c2q3e+q3fOv8DMwAA4jqu5goA2UGu4woAxUSuxmSLJFWt8BqmM1BMEkmu+Hqu9Mqq69qv+1qu 65qvAvuv+Squ6lqw/qqv6mqwDNuvAYuvBQux5lquB3uuBhuxB0uvExuxFquxC0uxACuuFTKxlKVS BWCyAKtPBltM9SoAIYuwIRuzMfuxDTuxFguyMruxOZuzNMuzNYuzHfuyMzu0Oxu0RVuudViu0CRW KsW0KCuu9sqyRzu1VFu1Vnu1WJu1Wlu1NEADM+C1Xvu14uq1Iyu2ImavCRhfX2tMZgtMNiC2cAu3 YSu2XVu0YAu2Y5u3ehu2fFuueHu3dAuweKu3fpu3g1u4gfu3hVv/t3fbtYA7t187uH8LuYz7uGCb HYFLWQlYAJvruCYLtsXEuJErupUbuYlbunTbuJXbt6X7uKMbuImburJbt6Y7u41ruq5LurCrurh7 u46rur8bvAgQvMknAF1rTJtbAOiWvANQvMT7vNAbvdI7vdRbvdZ7vdibvdd7A8HLvdzruN/7u6GL kAOAkNFkA+abTc4bvjTwve7bvvALv+8Lvr/rvfYbv+wbv887v/orv/XbvwBMv977v/07v/nrv/jb vQKcwDfQwAZsvw0svxE8wQhMwRbctRFcwe3rwBAswfebwR+8wSEcwiK8wSbMwR08wQ4swhzsvyn8 whiMvxe8wjTs/74DjMInjMPcCwE5XMMjrMMqDMFCnMI9HMQoHME8DAE63MM53LVK7MFFPMRBDMU8 fAM8XMIQrMQW3MIqzMJcfMRgHMZiPMZkXMZmfMZonMZqvMZszMY7cANvHMdw3MBvLMZ1fMd0PMd5 LMdxLMdwXMcOjMdzDMh6HMiFzMGAnMiGbMh9rMd8jMKPvMeDPMmDLMiEHMh+7Mia3MiT/Mh9vAON DMqeHMp//Ml4/Ml0fMei/MelDMqsPMqr7MqynMqt/MqoPMuinMu6XMq0zMe3XMim7MmV3Mmx7Mix rMvFjMyhvMyVrMy7fMy5PMzOHM3BDM3W3MrT7MvT3My2TM3YnP/N2/zMzszN4FzO5nzO6JzO6rzO 7NzO7uzONgDK8bwD8TzPylzPomzPyDzP+pzL+CzP9BzQAp3PAz3N+tzPAY3P/EzQ/0zQAO3M/2zP Cg3QC/3QCe3PFM3Q9IzQEX3RC13PzdZsG83PEx3SH+3RID3SGy3PCi3SLi3QJS3SFC3TMZ3QHV3R LZ3RH33SKM3SKv3SE+3RMG3T/mzSJr3SL23TIa3ULe3SJE3UKJ3TS93USG3UR13SSL3SPx3TTc3V Tl3VXz3VT33VM+3UKW3VaJ3War3WbN3Wbv3WcB3Xcj3XdF3XbY1ua43XRo1ueq3WfW3XgB3YIf3X eV3Ydk3YzcYE120dCAA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #333; PADDING-TOP: 0px; BACKGROUND-COLOR: #fff } H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DT { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .txt { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } FIELDSET { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; BORDER-TOP-STYLE: none! = important; PADDING-TOP: 0px! important; BORDER-RIGHT-STYLE: none! = important; BORDER-LEFT-STYLE: none! important; BORDER-BOTTOM-STYLE: = none! important } LEGEND { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.25em 0px 0.25em 1.25em; PADDING-TOP: 0px } DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .homepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .homepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .homepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .HomepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .HomepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .HomepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .HomepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } .HomepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } TABLE.menuIEFOUR { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; MARGIN: 0px; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURSIDE { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } TABLE.menuIEFOUR TD { FONT-WEIGHT: bold; FONT-SIZE: 70%; PADDING-BOTTOM: 0.2em; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; FONT-WEIGHT: normal; COLOR: white; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { FONT-WEIGHT: bold; FONT-SIZE: 0.7em; TEXT-TRANSFORM: uppercase; COLOR: = #6089b2; FONT-STYLE: normal } H3.navigationHeader EM { FONT-SIZE: 1.1em; COLOR: #ff9b06; FONT-STYLE: normal } .homepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .HomepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .homepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .HomepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-REPEAT: repeat-y; BACKGROUND-COLOR: #13709d } UL.menuDOM LI { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: none; PADDING-BOTTOM: = 0.2em; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; BACKGROUND: white; = PADDING-BOTTOM: 0px; COLOR: white; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM LI UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuIEMAC { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM A { PADDING-RIGHT: 0.1em; DISPLAY: block; PADDING-LEFT: 0.1em; FONT-WEIGHT: = bold; PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } LI.nosaved EM { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuDOM LI UL { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover UL { BORDER-RIGHT: #90d7ff 1px solid; BORDER-TOP: #90d7ff 1px solid; = DISPLAY: block; BACKGROUND: white; LEFT: auto; MARGIN-LEFT: -1.25em; = BORDER-LEFT: #90d7ff 1px solid; WIDTH: 200px; BORDER-BOTTOM: #90d7ff 1px = solid; TOP: auto; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-RIGHT: 5px; MARGIN-TOP: 0px! important; DISPLAY: block; = PADDING-LEFT: 5px; FONT-WEIGHT: bold; BACKGROUND: #ff9900; = PADDING-BOTTOM: 5px; WIDTH: 190px; COLOR: white! important; PADDING-TOP: = 5px; voice-family: inherit } LI.nosaved EM { FONT-WEIGHT: normal! important; COLOR: black! important; = TEXT-DECORATION: none! important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none! important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } .domArrowOut { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { DISPLAY: inline; PADDING-BOTTOM: 3px } UL.menuIEMAC LI UL { LEFT: -999em; POSITION: absolute } UL.menuIEMAC { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif)!= important; PADDING-BOTTOM: 0.1em; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } #user { PADDING-RIGHT: 2em; PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: = white } #mycart { PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: white } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.standards.css @import url( = http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { PADDING-LEFT: 1em; MARGIN: 0.25em 0em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-POSITION: 100% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.basic.gif); = BACKGROUND-REPEAT: no-repeat } #searchBox { BACKGROUND-POSITION: 0% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.search.gif); = BACKGROUND-REPEAT: no-repeat } #citationBox { BACKGROUND-POSITION: 0% 0%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.citation-finder.gif)= ; BACKGROUND-REPEAT: no-repeat } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { FONT-WEIGHT: bold; MARGIN: 0px; TEXT-ALIGN: right } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { COLOR: #f90; BORDER-BOTTOM: #ccc 2px solid } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { FONT-WEIGHT: normal; TEXT-ALIGN: left } #contentFrame .mainCol #footer { BORDER-TOP: #ccc 2px solid; MARGIN: 10px 10px 0px; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 7px; MARGIN: = 0px 0px 15px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; BORDER-LEFT-STYLE: none } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { MARGIN-TOP: 1px; BORDER-BOTTOM: #cce5ff 1px solid } #contentFrame .sideCol #citationBox .item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 0px 10px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .sideCol #relatedProducts UL { MARGIN-TOP: 0px; PADDING-BOTTOM: 8px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { PADDING-RIGHT: 0.5em; TEXT-ALIGN: right } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { FONT-WEIGHT: bold; COLOR: #9cf; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= WIDTH: 100%; BACKGROUND-REPEAT: repeat-y } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; WHITE-SPACE: nowrap } #personalnavSpecial { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0.5em; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-RIGHT: #069 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: #069 2px = solid; PADDING-LEFT: 2px; FONT-SIZE: 11pt; PADDING-BOTTOM: 2px; = BORDER-LEFT: #069 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #069 2px = solid; FONT-FAMILY: arial } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { LINE-HEIGHT: 140%; TEXT-ALIGN: center } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.home.jpg); = BACKGROUND-REPEAT: no-repeat } #logoCell { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.jpg); = BACKGROUND-REPEAT: no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; FONT-WEIGHT: bold; COLOR: #666 } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; BORDER-LEFT: = red 1px solid; BORDER-BOTTOM: red 1px solid; BACKGROUND-COLOR: #fcc } #browserWarning { BORDER-RIGHT: #c00 1px solid; PADDING-RIGHT: 0.3em; BORDER-TOP: #c00 = 1px solid; PADDING-LEFT: 0.3em; FONT-SIZE: 100%; PADDING-BOTTOM: 0.3em; = MARGIN: 5px 28px; BORDER-LEFT: #c00 1px solid; COLOR: #300; PADDING-TOP: = 0.3em; BORDER-BOTTOM: #c00 1px solid; FONT-FAMILY: arial; = BACKGROUND-COLOR: #fef } .invisible { OVERFLOW: hidden; WIDTH: 0px; POSITION: absolute; HEIGHT: 0px } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { FLOAT: left; MARGIN: 10px } .linkPrint { FLOAT: right; MARGIN: 10px 20px 0px 0px } .linkTop { CLEAR: both; TEXT-ALIGN: right } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { FONT-WEIGHT: bold; COLOR: #c00 } #errorList LI { FONT-WEIGHT: bold; COLOR: #c00! important; LIST-STYLE-TYPE: none } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #contentFrame #intro .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; PADDING-BOTTOM: 6px; MARGIN: = 10px 0px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { PADDING-LEFT: 2em; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -2em } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 8px; COLOR: #000; LINE-HEIGHT: = 150%; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalReferences .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { MARGIN: 0px; TEXT-ALIGN: center } #contentFrame #content .issueNav SPAN { FONT-WEIGHT: bold; COLOR: #f90 } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px 0.5em; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #ccc 1px solid } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-LEFT: 6px; PADDING-BOTTOM: 10px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none! important } .journalArticleMain #intro .item { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px! important } .journalArticleMain #searchBox { BORDER-RIGHT: #99c2d6 1px solid; WIDTH: 150px } .journalArticleMain #intro #searchBox .item { PADDING-RIGHT: 10px! important; PADDING-LEFT: 10px! important; = PADDING-BOTTOM: 10px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #565565; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #content .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content .prerendered TABLE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TH { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT A { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT[size=3D'+1'] { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #666 } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-WEIGHT: bold; FONT-SIZE: 14px } #contentFrame #content .prerendered FONT[size=3D'4'] A { FONT-SIZE: 14px; COLOR: #090 } #contentFrame #content .prerendered P { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; TEXT-TRANSFORM: = uppercase; COLOR: #f90 } .prerendered .firstLevelHeading { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .secondLevelHeading { DISPLAY: block; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { FONT-SIZE: 10pt; COLOR: #369 } .prerendered .referenceNum { FONT-SIZE: 10pt; COLOR: #369 } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/genlink.js function get_link(a, b) {=0A= document.write("" + b = + "");=0A= }=0A= =0A= function get_pdf_link(a, b, c) {=0A= document.writeln('' + b + = ' (Size: ' + c + 'K)');=0A= }=0A= =0A= function get_button_link(cgi, params, imgbutton) {=0A= document.writeln('

3D"Click

');=0A= }=0A= =0A= function get_text_link(url, linktext)=0A= {=0A= document.writeln('' + = linktext + '');=0A= }=0A= =0A= function get_htmlftext_link(a, b) {=0A= document.writeln("" + = b + ", ");=0A= }=0A= =0A= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/personalisation.js /*=0A= * Project : Interscience Redesign=0A= * File : personalisation.js=0A= * Creation Date : 25th March 2003=0A= * Author : Jonathan Sugar=0A= *=0A= * Various functions to deliver personalisation functionality.=0A= */=0A= =0A= // Pre-declare userName so it's available when we need to test if the = page=0A= // assembler ran OK=0A= var userName =3D null;=0A= var shcrtCookie =3D null;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Factory Methods=0A= =0A= // Simple wraper object to encapsulate the data for a co-branding item.=0A= function coBrandingItem(image, imageAltText, href)=0A= {=0A= //alert("Making new coBrandingItem:\nImage: " + image + = "\nimageAltText" + imageAltText + "\nhref: " + href);=0A= this.image =3D image;=0A= this.imageAltText =3D imageAltText;=0A= this.href =3D href;=0A= }=0A= =0A= /*=0A= * Insert the 'Customer co-branding' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert customer co branding. Loop through 'customerCoBranding' array=0A= * inserting XHTML where needed.=0A= *=0A= * NOTE: the array contains ONLY the resource location (the location of a = gif=0A= * on the file system), the required XHTML is then added where needed. = This way=0A= * we maintain the seperation between presentation and content.=0A= */=0A= function insertCustomerCoBranding(maxBranding)=0A= {=0A= if( customerCoBranding[0].image !=3D "none")=0A= {=0A= document.writeln('

');=0A= document.writeln('

');=0A= document.writeln('

' + imageAltText + '
' + imageAltText + = '
More Providers

');=0A= document.writeln('

');=0A= document.writeln('

3D""

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the 'My Area' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= *=0A= * My profile link absolute as this file isnt only run from w3 anymore.=0A= */=0A= function insertMyArea(userdata)=0A= {=0A= // just in case the page assembler isn't running.=0A= =0A= =0A= if (userName !=3D null)=0A= {=0A= document.writeln("

" + = userName.substring(0,33) + "..., access your
" + userName + = ", access your

My Profile"); =0A= document.writeln(getLoginOutLink());=0A= document.writeln("

");=0A= }=0A= if (menuloadedflag){=0A= wisMenu();=0A= }=0A= }=0A= =0A= /*=0A= * Insert the Customer Admin 'Login/Logout' link=0A= * -----------------------------=0A= *=0A= * Author: Bobby Jack, December 2004.=0A= *=0A= */=0A= function insertAdminLink(page)=0A= {=0A= val =3D getCookie("AID");=0A= =0A= if (val && val !=3D "-1")=0A= {=0A= document.writeln('

Logout');=0A= }=0A= else=0A= {=0A= document.writeln('

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the username section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert the username.=0A= */=0A= function insertUserName()=0A= {=0A= document.write(userName);=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the login/logout cgi=0A= * ---------------------------------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= * Had to change the links absolute as this file isnt only run from w3 = anymore.=0A= */=0A= function getLoginOutLink()=0A= {=0A= if(userName !=3D "")=0A= {=0A= return "

";=0A= }else=0A= {=0A= return "

";=0A= }=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the shopping cart content page=0A= * ---------------------------------------------------=0A= *=0A= * Author: Zhiming & Warrell June 2007=0A= */=0A= function getShCrtLink(logged)=0A= {=0A= if(logged =3D=3D true )=0A= return "

";=0A= else=0A= return "

";=0A= }=0A= =0A= function toggleShCrtLink()=0A= {=0A= shcrtCookie =3D readCookie("SHCRT");=0A= if(shcrtCookie !=3D null)=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "block";=0A= }=0A= }=0A= else=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "none";=0A= }=0A= }=0A= }=0A= =0A= =0A= =0A= function readCookie(name)=0A= {=0A= var nameEQ =3D name + "=3D";=0A= var ca =3D document.cookie.split(';');=0A= for(var i=3D0; i tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract | References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if (arguments.length >=3D 4 && arguments[3] =3D=3D 'cluster')=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln(' 3D"blank"

');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln(' 3D"blank"

'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x" + = liels[j].innerHTML + "

You do not have = anything saved in this menu.

";=0A= else=0A= tmpinnerhtml +=3D "

" = + liels[j].innerHTML + "

"; =0A= } =0A= } else {=0A= //setup var to see if more is required=0A= var more =3D (subnodeslength < lilength) ? true : = false; =0A= var flag =3D true;=0A= for (var j=3D0; j" + liels[j].innerHTML + = "";=0A= } else if (j > lilength-3){=0A= if (j =3D=3D lilength-2){=0A= var url =3D liels[j].innerHTML.split('"')[1];=0A= tmpinnerhtml +=3D "

" + liels[j].innerHTML + "

";=0A= } else {=0A= tmpinnerhtml +=3D "

" + liels[j].innerHTML + = "

"; =0A= } =0A= } =0A= }=0A= // set last two menu items to have no rollover and = a border at the top =0A= }=0A= menu.childNodes[x].childNodes[y].innerHTML =3D = tmpinnerhtml;=0A= // set default menu elements with diff style=0A= if (flag){=0A= if (more){=0A= liels[liels.length-3].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-3].className =3D "noroll";=0A= liels[liels.length-2].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-2].className =3D "noroll";=0A= liels[liels.length-1].className =3D "noroll";=0A= more =3D false;=0A= } else {=0A= liels[liels.length-2].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-2].className =3D "noroll";=0A= liels[liels.length-1].className =3D "noroll";=0A= } =0A= flag =3D false; =0A= } =0A= =0A= // set sub menu title for the msnu=0A= liels[0].className =3D "hoverTitle";=0A= // apply rollover functions to hide/show sub menus=0A= if (classname =3D=3D "menuDOM"){=0A= menu.childNodes[x].onmouseover =3D function(){=0A= // safari doesnt handle auto in absoulte = positioning correctly so this code makes the menus display correctly.=0A= if (navigator.userAgent.indexOf("Safari") !=3D -1){=0A= if(!window.devicePixelRatio) {=0A= this.getElementsByTagName("UL")[0].style.marginTop =3D "20px";=0A= this.getElementsByTagName("UL")[0].style.marginLeft =3D "0";=0A= }=0A= }=0A= this.className =3D"menuhover domArrowOver";=0A= }=0A= menu.childNodes[x].onmouseout=3Dfunction() {=0A= this.className =3D "domArrowOut";=0A= }=0A= }=0A= } =0A= }=0A= // deletes the sub menus on the IEMAC as they have a = background bug, will still remain on NS6=0A= if ((navigator.userAgent.indexOf("Mac") !=3D -1) && = (navigator.userAgent.indexOf("MSIE") !=3D -1)){=0A= menu.childNodes[x].innerHTML =3D = menu.childNodes[x].innerHTML.split(""=0A= var menu =3D document.all["menu"].children[0];=0A= menu.style.marginBottom =3D "-3px";=0A= for (var x=3D1; x" + tmp + "";=0A= } else if (x=3D=3D5 || x=3D=3D6){ =0A= tmptable +=3D "" + tmp + = "";=0A= } else {=0A= tmptable +=3D "" + tmp + = "";=0A= }=0A= if (x =3D=3D (menu.children.length-1)){=0A= tmptable +=3D ""; =0A= }=0A= } else {=0A= var tmp =3D menu.children[x].innerHTML.split("" + tmp + = "";=0A= } else if (x=3D=3D2) {=0A= tmptable +=3D "" + tmp + = "";=0A= }=0A= }=0A= }=0A= menu.innerHTML =3D tmptable;=0A= }=0A= };=0A= =0A= var menuloadedflag =3D true;=0A= =0A= =0A= var time =3D new Date();=0A= //@@@DM It was anoying me this error =0A= var ordval=3D (time.getTime());=0A= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/journalhome.js //=0A= // Homepage links format:=0A= // homepagelinks[i][0] =3D location=0A= // homepagelinks[i][1] =3D currenthref=0A= // homepagelinks[i][2] =3D type: "e" =3D end of line, "s" =3D separator, = "" =3D normal=0A= //=0A= var writeLinksTraceOn =3D false;=0A= function writeJournalLinks(filename, oid)=0A= {=0A= var url =3D new String(document.location);=0A= var urlpathinfo =3D "";=0A= var pathinfomatch =3D false;=0A= =0A= // Find the pathinfo in the URL - need it later (probably)=0A= //=0A= // Both url and currenthref are expected to be of the form:=0A= // .....//[/]=0A= //=0A= =0A= urlindex =3D url.indexOf("jabout");=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("mrwhome");=0A= }=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("collectionhome");=0A= }=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("bookhome");=0A= }=0A= =0A= if (urlindex !=3D -1) // If found a known CGI name....=0A= {=0A= // We needs a pathinfo match.....=0A= pathinfomatch =3D true;=0A= =0A= // Find the end of the cgi-name=0A= urlindex =3D url.indexOf("/", urlindex + 1);=0A= =0A= // Look for the start of pathinfo=0A= urlindex =3D url.indexOf("/", urlindex + 1);=0A= =0A= if (urlindex !=3D -1)=0A= {=0A= urlindex1 =3D url.indexOf("?", urlindex + 1);=0A= =0A= if(urlindex1 !=3D -1){=0A= urlpathinfo =3D url.substring(urlindex + 1, urlindex1);=0A= writeLinksTrace("urlpathinfo: " + urlpathinfo); =0A= }else{ =0A= urlpathinfo =3D url.substring(urlindex + 1, url.length);=0A= writeLinksTrace("urlpathinfo: " + urlpathinfo);=0A= }=0A= }=0A= }=0A= =0A= var colnum =3D 0;=0A= =0A= for (var i =3D 0; i < homepagelinks.length; i++)=0A= {=0A= var location =3D homepagelinks[i][0];=0A= var currenthref =3D homepagelinks[i][1];=0A= var type =3D homepagelinks[i][2];=0A= =0A= writeLinksTrace(location + " : " + currenthref + " : " + type);=0A= =0A= if(type =3D=3D "x") // End of the list=0A= {=0A= break;=0A= }=0A= if(type =3D=3D "s")=0A= {=0A= document.writeln('
');=0A= colnum =3D 0;=0A= continue;=0A= }=0A= if (colnum > 0)=0A= {=0A= document.writeln(' | ');=0A= }=0A= =0A= var hrefindex;=0A= var urlindex;=0A= var greydisplay =3D false;=0A= =0A= // See what type of link we have=0A= =0A= // Cases here are for URLs with no /relevant/ pathinfo=0A= if (pathinfomatch !=3D true)=0A= {=0A= hrefindex =3D currenthref.indexOf("jhome");=0A= if (hrefindex !=3D -1)=0A= {=0A= urlindex =3D url.indexOf("jhome");=0A= if (urlindex !=3D -1)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= if (hrefindex =3D=3D -1) // Didn't find jhome, try jtoc=0A= {=0A= hrefindex =3D currenthref.indexOf("jtoc");=0A= if (hrefindex !=3D -1)=0A= {=0A= urlindex =3D url.indexOf("jtoc");=0A= if (urlindex !=3D -1)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= }=0A= // Add more non-pathinfo cases here...=0A= }=0A= =0A= // Cases under here are for cases with relevant pathinfo=0A= if (pathinfomatch =3D=3D true)=0A= {=0A= var hrefmatch =3D false;=0A= var hrefpathinfo =3D "";=0A= =0A= writeLinksTrace("pathinfo handler");=0A= =0A= // Find the pathinfo in the href=0A= =0A= hrefindex =3D currenthref.indexOf("jabout");=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("mrwhome");=0A= }=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("collectionhome");=0A= }=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("bookhome");=0A= }=0A= if (hrefindex !=3D -1)=0A= {=0A= // We needs a pathinfo match.....=0A= hrefmatch =3D true;=0A= =0A= // Find the end of the cgi-name=0A= hrefindex =3D currenthref.indexOf("/", hrefindex + 1);=0A= =0A= // Look for the start of pathinfo=0A= hrefindex =3D currenthref.indexOf("/", hrefindex + 1);=0A= =0A= if (hrefindex !=3D -1)=0A= {=0A= hrefpathinfo =3D currenthref.substring(hrefindex + 1, = currenthref.length);=0A= writeLinksTrace("hrefpathinfo: " + hrefpathinfo);=0A= }=0A= }=0A= =0A= // If we found a CGI matches in currenthref, and the=0A= // pathinfos match then grey this link=0A= if (hrefmatch =3D=3D true && urlpathinfo =3D=3D hrefpathinfo)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= =0A= // Time to write the link=0A= if (greydisplay =3D=3D true)=0A= {=0A= document.writeln('' + location + '');=0A= }=0A= else=0A= {=0A= document.writeln('' + = location + '');=0A= }=0A= =0A= // Defunct - separators now worked by from colnum=0A= // If end of line skip separator=0A= //if(type !=3D "e")=0A= //{=0A= // document.writeln(' | ');=0A= //}=0A= =0A= colnum++;=0A= }=0A= }=0A= =0A= function writeLinksTrace(message)=0A= {=0A= if (writeLinksTraceOn)=0A= {=0A= document.writeln(message);=0A= }=0A= }=0A= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/96516027/FILE?TPL=journal-article.html-navbar&mode=html Navbar


	Home / Medical, Veterinary and Health Sciences / = Oncology =

3D"Utility

3D""=20

------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/txt.jump-to.gif R0lGODlhOQAQAKIHAP/x3P/WmP+8V/+yP//lv//Mf/+ZAP///yH5BAEAAAcALAAAAAA5ABAAAAPM eLrc/jAyIE8xihiiTMkGpgiecoUCt5xhyJHGQEEXqJaHZszhZ3mnWa5wIgIChoBGEKnlNh2fZhA4 AGI+p6baGAwWXpOIIBTboqACs+DNjqHdb4d5QAKuvtX7Jt1gBmxuXjFlCmFoTxyFP2cHOBqOGgCA YgMCAYsHh450GiorVVpwj38Df24Vm4dODISmCldMSCqQSEyUjBKbF2QxJjNIPQswBnRPVkmaqLpy VqYhFHgLAGQN1JkV2Q0E1bDa3+Dh4uPk5ebn6Onq698JADs= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #333; PADDING-TOP: 0px; BACKGROUND-COLOR: #fff } H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DT { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .txt { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } FIELDSET { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; BORDER-TOP-STYLE: none! = important; PADDING-TOP: 0px! important; BORDER-RIGHT-STYLE: none! = important; BORDER-LEFT-STYLE: none! important; BORDER-BOTTOM-STYLE: = none! important } LEGEND { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.25em 0px 0.25em 1.25em; PADDING-TOP: 0px } DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .homepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .homepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .homepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .HomepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .HomepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .HomepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .HomepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } .HomepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } TABLE.menuIEFOUR { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; MARGIN: 0px; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURSIDE { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } TABLE.menuIEFOUR TD { FONT-WEIGHT: bold; FONT-SIZE: 70%; PADDING-BOTTOM: 0.2em; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; FONT-WEIGHT: normal; COLOR: white; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { FONT-WEIGHT: bold; FONT-SIZE: 0.7em; TEXT-TRANSFORM: uppercase; COLOR: = #6089b2; FONT-STYLE: normal } H3.navigationHeader EM { FONT-SIZE: 1.1em; COLOR: #ff9b06; FONT-STYLE: normal } .homepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .HomepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .homepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .HomepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-REPEAT: repeat-y; BACKGROUND-COLOR: #13709d } UL.menuDOM LI { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: none; PADDING-BOTTOM: = 0.2em; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; BACKGROUND: white; = PADDING-BOTTOM: 0px; COLOR: white; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM LI UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuIEMAC { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM A { PADDING-RIGHT: 0.1em; DISPLAY: block; PADDING-LEFT: 0.1em; FONT-WEIGHT: = bold; PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } LI.nosaved EM { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuDOM LI UL { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover UL { BORDER-RIGHT: #90d7ff 1px solid; BORDER-TOP: #90d7ff 1px solid; = DISPLAY: block; BACKGROUND: white; LEFT: auto; MARGIN-LEFT: -1.25em; = BORDER-LEFT: #90d7ff 1px solid; WIDTH: 200px; BORDER-BOTTOM: #90d7ff 1px = solid; TOP: auto; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-RIGHT: 5px; MARGIN-TOP: 0px! important; DISPLAY: block; = PADDING-LEFT: 5px; FONT-WEIGHT: bold; BACKGROUND: #ff9900; = PADDING-BOTTOM: 5px; WIDTH: 190px; COLOR: white! important; PADDING-TOP: = 5px; voice-family: inherit } LI.nosaved EM { FONT-WEIGHT: normal! important; COLOR: black! important; = TEXT-DECORATION: none! important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none! important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } .domArrowOut { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { DISPLAY: inline; PADDING-BOTTOM: 3px } UL.menuIEMAC LI UL { LEFT: -999em; POSITION: absolute } UL.menuIEMAC { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif)!= important; PADDING-BOTTOM: 0.1em; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } #user { PADDING-RIGHT: 2em; PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: = white } #mycart { PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: white } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.standards.css @import url( = http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { PADDING-LEFT: 1em; MARGIN: 0.25em 0em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-POSITION: 100% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.basic.gif); = BACKGROUND-REPEAT: no-repeat } #searchBox { BACKGROUND-POSITION: 0% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.search.gif); = BACKGROUND-REPEAT: no-repeat } #citationBox { BACKGROUND-POSITION: 0% 0%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.citation-finder.gif)= ; BACKGROUND-REPEAT: no-repeat } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { FONT-WEIGHT: bold; MARGIN: 0px; TEXT-ALIGN: right } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { COLOR: #f90; BORDER-BOTTOM: #ccc 2px solid } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { FONT-WEIGHT: normal; TEXT-ALIGN: left } #contentFrame .mainCol #footer { BORDER-TOP: #ccc 2px solid; MARGIN: 10px 10px 0px; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 7px; MARGIN: = 0px 0px 15px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; BORDER-LEFT-STYLE: none } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { MARGIN-TOP: 1px; BORDER-BOTTOM: #cce5ff 1px solid } #contentFrame .sideCol #citationBox .item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 0px 10px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .sideCol #relatedProducts UL { MARGIN-TOP: 0px; PADDING-BOTTOM: 8px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { PADDING-RIGHT: 0.5em; TEXT-ALIGN: right } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { FONT-WEIGHT: bold; COLOR: #9cf; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= WIDTH: 100%; BACKGROUND-REPEAT: repeat-y } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; WHITE-SPACE: nowrap } #personalnavSpecial { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0.5em; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-RIGHT: #069 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: #069 2px = solid; PADDING-LEFT: 2px; FONT-SIZE: 11pt; PADDING-BOTTOM: 2px; = BORDER-LEFT: #069 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #069 2px = solid; FONT-FAMILY: arial } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { LINE-HEIGHT: 140%; TEXT-ALIGN: center } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.home.jpg); = BACKGROUND-REPEAT: no-repeat } #logoCell { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.jpg); = BACKGROUND-REPEAT: no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; FONT-WEIGHT: bold; COLOR: #666 } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; BORDER-LEFT: = red 1px solid; BORDER-BOTTOM: red 1px solid; BACKGROUND-COLOR: #fcc } #browserWarning { BORDER-RIGHT: #c00 1px solid; PADDING-RIGHT: 0.3em; BORDER-TOP: #c00 = 1px solid; PADDING-LEFT: 0.3em; FONT-SIZE: 100%; PADDING-BOTTOM: 0.3em; = MARGIN: 5px 28px; BORDER-LEFT: #c00 1px solid; COLOR: #300; PADDING-TOP: = 0.3em; BORDER-BOTTOM: #c00 1px solid; FONT-FAMILY: arial; = BACKGROUND-COLOR: #fef } .invisible { OVERFLOW: hidden; WIDTH: 0px; POSITION: absolute; HEIGHT: 0px } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { FLOAT: left; MARGIN: 10px } .linkPrint { FLOAT: right; MARGIN: 10px 20px 0px 0px } .linkTop { CLEAR: both; TEXT-ALIGN: right } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { FONT-WEIGHT: bold; COLOR: #c00 } #errorList LI { FONT-WEIGHT: bold; COLOR: #c00! important; LIST-STYLE-TYPE: none } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #contentFrame #intro .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; PADDING-BOTTOM: 6px; MARGIN: = 10px 0px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { PADDING-LEFT: 2em; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -2em } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 8px; COLOR: #000; LINE-HEIGHT: = 150%; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalReferences .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { MARGIN: 0px; TEXT-ALIGN: center } #contentFrame #content .issueNav SPAN { FONT-WEIGHT: bold; COLOR: #f90 } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px 0.5em; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #ccc 1px solid } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-LEFT: 6px; PADDING-BOTTOM: 10px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none! important } .journalArticleMain #intro .item { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px! important } .journalArticleMain #searchBox { BORDER-RIGHT: #99c2d6 1px solid; WIDTH: 150px } .journalArticleMain #intro #searchBox .item { PADDING-RIGHT: 10px! important; PADDING-LEFT: 10px! important; = PADDING-BOTTOM: 10px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #565565; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #content .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content .prerendered TABLE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TH { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT A { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT[size=3D'+1'] { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #666 } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-WEIGHT: bold; FONT-SIZE: 14px } #contentFrame #content .prerendered FONT[size=3D'4'] A { FONT-SIZE: 14px; COLOR: #090 } #contentFrame #content .prerendered P { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; TEXT-TRANSFORM: = uppercase; COLOR: #f90 } .prerendered .firstLevelHeading { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .secondLevelHeading { DISPLAY: block; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { FONT-SIZE: 10pt; COLOR: #369 } .prerendered .referenceNum { FONT-SIZE: 10pt; COLOR: #369 } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/96516027/toc.html,journal-article.html-sidebar Article Table of = Contents

Cancer
ISSN: 1097-0142 = (Online)
ISSN:=20 0008-543X (Print)

Volume 95, Issue 2, 2002.
Pages: 249-257

Top of page
Abstract
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
References

Tables: 1, 2, 3, 4
List of=20 Images
Abstract=20 Only

------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/rss_feed.gif R0lGODlhDwAPANU6AP///+J7AONfAOJrAP2jFeJzAP50APro1v63KP6xI/qLAe5rAP6rHeNlAPOa E/yVCO+YR/j08fS0SuadM/Lj1ei4hu2PCuaCAuuXEuzJlvp5AOBxGem1edGcVOe3Zul5APaEAPdv ANmyjPHax+3f1eyDAOd7HeymY/K9fPjly9NkAOt3ANGNSd+aQvOZL9JZAPnj1MiJS/fRjeJ/IPyF AOyjKvR0APOEHfO2Z+KXLv///wAAAAAAAAAAAAAAAAAAACH5BAEAADoALAAAAAAPAA8AAAahQN3k Eigai5eJTujwZDIyCWI6deR0gYQHwAUcJIlwIqArMGqdjojCRTHehTKBgMHQKxEAZx4vECxcBzgO LXkSDnEDDxYjJFwZFhwAKQ8DOooPChcxeSclbC6WAwoKJaQsXiCSKKIgB140H44fEAAVlg0zXSsa IwAqtRUNOg0LbDAaGiYQNjciJ8MmCwsvIQbX2CELG0sbAt/g4dxL5OXmS0EAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/link.journal.homepage.gif R0lGODlhDgEuAMQAAKzN3u/1+tHo/0WPtXityf6gFPX46gBmmfL38ZC80/nRgyB5pjCDrPbtyL/Y 5vH2987i7NXl7qHGxtXl3OLt6d7r9BBwn8DZ1Onw4QBZlOjy9+vz+LfCqebv9uDv/ez0+yH5BAAA AAAALAAAAAAOAS4AAAX/4CN6QmmeaKqubOu+cCzPdG3feM56ovgJmk9gSCwaj8ikcslsOp/QqHRK rVqvSY3gM9o8EOCwOGwom8/lsRrca/ew8Lh8Tq/bib+HR/Ndk9GAgH5hbm53h4iJiotPHh4VfX6B k4GDCIVvjJqbnJ1UPxWDlGUNCqWjg5iZnqytrpsCoWujZQW2CrQGqapKFUy+Q8C/r0UAwkvCxxXH RhB1ysRHsbO5CrYNubprIg4MBwsSIkkDAEsEBEPkTerRBAwOThZDDgNF50kA9XPsAfTRRtPGZKtV YKA2NRQsJHgAgIA4Y0UgMCDgrF/FYOfgkYM4BMLFdAA4WiziwJfICvCI/6AkAqEcEZcvm030VQFm AI9EHBwwlg9CSpwBAHxcOYRjyZsVgdYsVpGfO5giX15cGswmzJrAsDoJ+GegKYMHxUgY4AbCggHg iCSwwCBBgAEMFqCbt0Du27MWnBFYMLEI2gF538ZFR8ACYAaAnUk4y6CmhbroJCBuXAHxggM3zy5I GWDtu8VoW7KdG4DAgQEOALC1ew8uAwkv65lFC1vdOdV9DzDYnQ6tW34MDGem7dd3AAlsGRxPPnxz BcMMIDyH+zEJVwRgMTTAADYsmHMizkG4B0A5EXVjAzwXdu8t7HPPQy64OOA9gfTr7+lH1zZfgvJD zFfBOQwAkAA6FWB2W/97IAXwTmkEAGgEZkEp9xyEAShkRD4YAmhbhOYFcIAvDzZEQD38cNhhiEGd U8+DzsAIoYkOLOBSjTYtwdVAE1xwwTkRXjABd7moIYFDD+yVDwAPiOhXOe05NdeHDhg2AGrnQQkk SPthaOUA/+lDzgDnWGDiEJjBdSVpb5VD4ZL6FPGmPgqiQ48FsBWFoktpaqmik20CINeVbcbWIKBB DVoPhWj6hRiZx8WlmKRN7GgGBl+dMcGR3gyQQVwZgHkBBUWKkdBCqiXp0IlPotRYlfYQ4MuHGZb0 EZWvytNla3YmKp0F61Vg41g1KVgPZw2C+VaEcRKBWU10YghbAnFyqB//iuiQ+SeF5FxbqJ6+eDuE t2BW8FsC5pZ2rHpaLsWgEgGh0UABmWKQDwH0uHWAR2eZeMEZCuByhhrd6ObAAwOehqxpbhWW1ksW ZKtlohE/iaHD9l2MDgQDHICOoMG55RmWpnU87mm3lkOPx9AeAVhq0cKHsaEJY1mjYWE6C1IFgEHK j7ALqFcyZzwbZqc3R3t88gA+dRzdytFVKssZpdxiAAZPdTZAByKWoxo8Y0nA3bz0orENJv8w8acS NbrybtqJTCOvNdfs1VY3Fe00LgMRJBAyprYUgI0ZZxcCN9t5KqFkKxxXd/gdcsvbwOQckHNgXABE ICIEHUCQwGkEhMlB/8ABD074GLw8rvrq0UQeyATKqhexmroh5k5jQ1A7ASWFt8H678Bz4jogxHbE dGqmhS6UoFyrVx/vYVDARhsQiFMEM4dgX4XjVdCUVRPca9+E+El830oslMDuVu6yOssZx5ydSGol YVgwvQjCWk+EPIq83X3QcdCVxNTWrP1NwR9PYAf/WIG+SVwAS+kgQPNExJkIQEpP/5oEGHQCAAqI wCMMwR9HKKSVI5QwKB8pB1VigiH1IOslwojKUYLCwqJwz4XFcJJHJEKRjiCrJEQpIaM6YhOfqARm G6rIUXY4EWeMyCYO+MgM69DAQORDc0Noi5w4swFWDcGCGaTf0HDjkP8DIEwz8HgWdKoznahdaQG/ 4UtceCMiOQ4oMowRBgQMk5fZpKVnFkhjczSym8QRATSUsUydPNMwvtSjMNqqh7DQIshDTsYxg+kH Xpr1xt9oiZEi2o154MIao0GuApSQTBT5lYAdQuAArfSIA9wRAVm+BnoIOAAYytMDMz7gQJDCDI6Q MMyiuMg9DoJNgUQUrgPxJ0zrw5BePqac+nQGHXU6k4aQ0B8wHUg9dSqUsGZ1pLmoCJjYvB6BQmIh XbklPS85Jq3YMSIHOQA/wPLfHKpIvAwc4J8ADahAB3qADAAAl7pEQD56mSQy5WYIkpnPESLaEkUV Sh3qoBCQ0PGlaPL/g56F4lCaHmUnwBhyCB1tTzjVoaKN6kld7kjnecoUkmixtFoWnSefuDSlMx2C n2iQjHSWYaNlLGMnRo2AO4wqEQkgFAEUWKgIzGjNYLILQuNRiZbIVQ6Muqmr5VxWP2LVmTuqS6z3 MNZYj6O10tCnV8QCwEoh4pzNtIdDVZUpSola00aJ62LYEis5fMEtAHQDJQJEBFDP0BMiwHEDzoJJ B7x4kwGEURBgeJlUH2DGGp1FX/1wGgTgGVrdSKdnA/SqiDpGmI2x9nodG8AyhvaWnhF2adLBWIIi 8trSnOaRhIHlcRZQsbseqy7KGuLIkOikol3Qeaa8mbIYBijbPCZj/z9FpQOlJAy9fTF2QbEsLgmB NiboMwpDvAI/nLC24LmXCIu91DmEEN4IbKADHdhJBzSwgW6k5APnIBL9xJC6JUgHC2y6QvugUIEb vvd3w0ND5f5rI2oBdCIJSAAAQzu6yZnudAQu74NHTGIqRHhe1lAAfGoSnAi9MgEOsPBgLUgAutHr w71bRYl3zGMdhUJegWsA7NSUD2AcICV+o4cjJ1A1wZktDBC4Xw+iGAdgOPhx5OtxJ+IFsLIZYAKI cUAXCaABCmrSAR3oxgB2ZwAUY1ahA7iEGzQcTStE6YWrO6+Wtzw1wpVCwBTYS4T0uxOJoOZKCZCX gNMQPQfIOYoIE//PVY8YkxWiUGj46oeVkWXEJHQah0jRNA0vTcwfXsQjb8MJlatyvZ9wrwB7hgKX afGj3cjlt78lAJtpIYZ8IACSePJsAkAj0drdxdZ07KRnB2i3euDGLhtaDR7hYi6OSqAbgnnNEU7U F2BPiy8VKwpboIOn4YYmlMqxW4IDYItYb0UW2MnGBAy0UQlcYNGo6DVZwDMWVdkTQ/VEpraXaSLg 7mwB5ATQhTbUTgdB0yw12tI2jzAe00irHhJlEIAkc5wXwSOtNDGToKoTOHcz4TrdyRRYxrBQ8LRc piLN0kXlcyKDB0oft4nWhqLV0QDIRcPquNNJhXWOcMa8heFN+tH/j16lK0GQCIGDtcmtA+94D4Rs 3VHDyxmy72z9Rq+q7RZhgDurctSVuZgxkKGcBKmUmIZjAJwW00iDbZ106EUS4BlpOMR3FH0dUYFs 8HGEUfKpU10gXrmGQdaw9ZeXtn2MCrsxUBuUiqGHuB+L2d6jxTGlDfesA7ouaX1LKPIc97OG6vvj b1sUzCcT6lI3PBKuA4ZsYCBwAiuVGlTRpFY8HcHrfkXsZS+NqndlFKU4he53L2JW4NkKBya+e2l/ /O4MmPnNl772H0f96lsfxNg33PbHz31IWOL74A+/+MnP/tYJQASWsPriLcH73rf//q4oQQ/iX/vl +6H++BeA52MCGkZVgAZ4gAiYgAioAwzYgA74gBAYgRIoAyEAADs= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/icons.email-print.gif R0lGODlhWgAUAJEDAMzMmf///wBmmQAAACH5BAEAAAMALAAAAABaABQAAAK1nI+py+0Po5y02ouz 3nyLDwrdSCZCgKZiiYRuyC5nGKwxmObop4k2c9L9IsPGp6bb1ThFUw3XrDSPyFzQxmu5BjDfI2g1 Zrs8kIJaTa/WLQPbzY0DX9sznI2XgZH7tbkMF/cnJwNgeIg4dbcoqCckFGgSONZ4RncpWelVabKX tOSWNRk6OIV4ejpkJrfpU3T5EuNmKIBKS5uJAQsjy0ULi9vWOzxrixpF3Lsbm9zs/AwdLV1SAAA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/txt.search.gif R0lGODlhMQAQAKIHAPHp2vfFd/m6WPXQl/Peu/uwPv+ZAP///yH5BAEAAAcALAAAAAAxABAAAAPL eLrc/jAyIEoJK9g9WBGTJQTEQlmdEmBKMRSGAbPw5i5EDOAybKQCQ8VQOlgWhoDuIAAZDZBgklcC xA5Wp6xVQGqIDRhEGKS2oLkiYGfsKpI5Gfu5macHBnZuBAMpix49M1g+KTUWc2VWLHExATt/DoeD CnFnDzIEOW5pewp4gAtHbytFMDtiDY0xeQdpTyU5hk6jB0mZUmeamjtBbFYdr1ZuOp5tXnishqwx XVtIXa9MYKtstVMAvBLbEdkEc9zh4uPk5ebn6Onq5AkAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/but.go.gif R0lGODlhHgATALMPADhqm7u6u26Uuv///7TI2522ztbW1pCPkYqmwunp6fPz88vX5PH1+eLq8VN+ qf///yH5BAEAAA8ALAAAAAAeABMAAASm8D0iqr04V0TkXEMojmQZMktHgGbrDqnwzqRiVHRuB3jJ FA4AAMGY7XokAWBVGBoNPBmJsBQVCCGKoFCDIq2AUGOxaAyoV6foKB01QwhhWOCAh9fetmhRDb17 b3hRJkorBEEDTQ0MDnpsJgxxQghmA5ICRYJfOS2PnC8JeSEKCaWmp6ipoQEIAisGUAGys7S1tgEH ByoICLm+v8DBvwUeWhrHGh0PEQA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/dot.CCC.gif R0lGODlhAQABAIAAAMzMzAAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/icon.bullet.orange.gif R0lGODlhCQAJAKIHAP/AYf/Ri//Jd/+hFP+zQP/15v+ZAAAAACH5BAEAAAcALAAAAAAJAAkAAAMq eBdAFOqIUKogi15QQOvEYBDFMJRGahTGSajkwBQvCQgHwVmYIogG3CEBADs= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/dot.clear.gif R0lGODlhAQABAIAAAAAAAAAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/10/dagger.gif R0lGODlhBwAQAPEAAAAAAP///////wAAACH5BAEAAAIAIf4lICBJbXBvcnRlZCBmcm9tIEdJRiBp bWFnZTogZGFnZ2VyLmdpZgAsAAAAAAcAEADBAAAA////////AAAAAleUJCIiAiCEEEIAIYQQAAgh CAIACIIgCAAgCIIgAIAgCIIgAIIgCAIAEAgEAgEAIBAIBAAAAAAQCAQAgEAgEAgAAIFAIBAAAAKB QCAQAAQCgUAgAAgEggIAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/bull.gif R0lGODlhBQAHAPcAAAAAAP////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////////////////////////////////////////yH5BAEAAAEALAAAAAAFAAcA AAgTAAMIHAigoMCCAA4aHMiw4cCAAAA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_here_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISAABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxInRgSQcMAAhRwPevS4EeHIjwczXiNZUmPJhhAphnR5rWLM gxhnuizIU2BAAAA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_down_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISQABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxIxaNx4UOLEiACubRyJ4VpGkh1DHhwJMqFGhSEbQqSo8mPK hwkx1rRZsKfAgAAAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_up_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISwABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxIPYsCgEADCjRsjerwGEuTBhSVLXss48eTIlBxXemwIkeLI li4fJsR4E2fBnwIDAgA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/mu.gif R0lGODlhCgALAPcAAAAAAICAgIAAAICAAACAAACAgAAAgIAAgICAQABAQACA/wBAgEAA/4BAAP// /8DAwP8AAP//AAD/AAD//wAA//8A////gAD/gID//4CA//8AgP+AQAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAA4ALAAAAAAKAAsA AAgnAB0IHEjQAYCBBwkmNFhw4UKBDhsilGgwoUUABzFGLDiRI8SHAwMCADs= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/prime.gif R0lGODlhBQANALMAAAAAAP////////////////////////////////////////////////////// /////yH5BAEAAAEALAAAAAAFAA0AAAQNMMgZAJgXa8q7/+AUAQA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/le.gif R0lGODlhCwAMAPcAAAAAAICAgIAAAICAAACAAACAgAAAgIAAgICAQABAQACA/wBAgEAA/4BAAP// /8DAwP8AAP//AAD/AAD//wAA//8A////gAD/gID//4CA//8AgP+AQAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAA4ALAAAAAALAAwA AAglAB0IHEiwoMGDAwEcBMDQYMOCDBUiFPhwYkWEFy1G3ChxooOAAAA7 ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/96516027/tfig001 R0lGODdhVQB4APcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///ywAAAAAVQB4AAAI/gD/CRxI cJ0/gggTKlzI8CDDhxAj8opIsaLFixUnYtzIsSNCYQLnaRo47Jc0jyhTLrwlMF+rge3YPVJJs+ZA jQMv2dyZshdCRKV4Ct3oE+HIoUgpFiW4KanThzgHSuLV7KlVgr4SclMX9apQVQL7sUTYr1hXrzbP URLobpJCabdmzUOrcpurcgp/va137RxdlXyS5VWoDto1dH9TcpI3WCE1dakSeyTXCnFCvQqP+Rsm 2WOmuZcXWtvcuaMmv6EVfjsXzdeneDQdJhV1bSC3gZgV1v7H7F1pi+UKWT6HR+A6SAx39/5d8Rss co0zC2SnS5ds5gx1iYuekNqzfgI5/mN/6K+T79QLs+kLP/6hOUXruCd0d/IfsGLFgLVPOK+St3/X /ZPbQs1QQ5B++yH0hzPyKdRMPgMhmKBA2ojyn0AMCiQhQ/Cg9g8ru0w4EBv1nTPTP+Kc+JA+0HQz UDAiCmTKOAptyBA/wrgjEIwxnlFNjRXNI0w11ohCTYAcIZlSKrehZ1E4pPQSjDDDEINfMcYYgx8x w0Tm1TizmAPkRulQ4yJEZxG0zz9rlgPON880udE0mkCXkI0XYSORQrL0IUgnjvCRSSel0OLLKh6B NyZHeqKpUDrbYPONNOB0A8457JADT00Z2ufRbg/h0osvvwAzJZVVWpnlMci06iqr/sfYw5E6nggk jlsdUVPNMzH2s6aGKUGDTTbEnjchnihJg8899thTTz30zCPtPPJUG8+118Kj7XpDIeuRN9x00403 3nwDDjjhpCuOOOO0S86775Yja7dXsfMPPgLhI000z2xz1YBJ3YLIIX+UEoonrPQiy1VZWfXOOeiM ww4868TTDr6K8lTPQA3HmFIbAl3jiMcqXfjPUiSrhHLKKNmyCy+56MLLzLzskgsuttQySyuxxCKL z7PUYsstt8Ciy8s007xLLLncjMsttkRdSy2xtDLLLLJkrbUsq7yytdY9y2KKLLRkQ9FqDxET6kPM PPQOqAllY6xCy7Bs990JHfMN/kPUmGK2g6Oks5A3piDDECaZKFlNK5oIlhA/tIjyUkW/+LvQMa5o sxAuoMT31ij1KWSKKkpmowssBibUjy6v5NaPknhXBEyaTrkzjm/+6PgUKYH8Zc0bu7RiSiC13JOU N9nAEs5f2oSzDObLbBz79NRXb/312GffkfHaR3RM9xGtDD6AxgwkPnOwY+SPLQJt08hA0wwjjCjA +MLLKDRqD/A/P7aPl/Z4UgY1dKWLW2TJW3fj0UKYARoE2g0kDGGHMqDTsepB8CGGm0b/qieeh3Tj GtYwxfLuxo9XCEQfIaJIPzwxCzmljBy4EkdTKvKOZKRORMo4xa8Q0sGIvIMZ/uugRqf2Qw834Csh aqtIPnbRtmpQAxoJmscmMkaQJFaEHx2cBj32Q41I7LCKF+FHJYIxpVkUYz/w8AQVB2JFJebjjfno BT24xRx4kIIfCmnjRnbxjWiMJx6Q2CGo9IiRYMiDGMfooWS+sQc8/sN9AgGHJVBiDmlY8hPUaJRA 0tetS0AIiTWBkeY6g49mrFEghOyI2sZRjWo4ji5SVFIqOTIOmvXCE15CCzowccp/XHAn+1gLXY6x hi++CCmk8NBV3jEIRyJkfzW5hSh0wSuK7GMf9sDHETFSDDvQsXz3qkVSvAMJZw5EHa0oRStucQla YOIaXjiEJ3R3kXg0UiDd/kCFQMYxyaTYAxSnZAcwYmE/WSRjF+nQYDY+eRF3AMKc5nOKPQpRiaRZ 9KK88NxG2uEGYwqEdjthhjVMBhFoUgQegYDoR9XXkQ1CpIIX+cYoeglSnngDG8PyI0PORxFhsEKl /6gpUqwBlY7U438JEepQuNFKa1RDmUGlCT+guNLS+MNyN6FJOUYRMhVJxh96XJhK+OFMpT5llAOp FU/M6pRrtHKA1PiEvezFmH/I4xnKkMY0NsJWtATjR60QhBzaYAlOWMIVsJgFXyf0VzbdAx/2yIc+ JJsPoDoqQcEABlzh+tbNzu2y+1HgQ/iBVoXkQ6cnYyxF+IFVhYxDmNdY/sSE4MaQfliGIjAdH0Jy WxNO/iUYV9pFMbgkjMz+YhYYjcUuSnWqYeRiGFuyUn54IV38ZAkX1cUSlnRxJeIKoxbAAMYvfOGL XvSCFjTLH0T6AQuF6EIhwoANQnoxL4KIA7UE0cU2CXI+WtRov6vVrYAx0g0XCqQdr9DkCU9B23sE w3AE6YcpFIuQYwRjFhr9xzqOkYq/DcSGt7DXQPLqX4sUQ5H/AIck9OiNPZyRIN5IBIUH0g9HHIUg tmCFJbYzEHOo4hLJuM4tTGGJEQqkFoeIxEDCMQweD3gg2DAFcuhij3gYjx90RAo2RmGIv8RCD8XI hS0m4cCS7eKVXrmHDjGsYYxhcOK9CfGtRQICADs= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/96516027/tfig002 R0lGODdhUAB4APcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///ywAAAAAUAB4AAAI/gD/CRxI UBjBgwgTKlzIsKHDhLceSpxIsSJBXBYzatz4DyPHjyAX5gpJEqS5gR5LqrRYS+CvUALjsVpJ0yE7 lAM11dzpMGUwnkAVptwkL6hRnAJ7KTt6NKW0Xg/9MXVoDJXQgeB4TQ3Jzg7BUwKHiRoYThO9rR/h eRqITue/fhEFhpOmDS3HZ5QUxv3nrtswuxvbpdJLMJtBwBnRASM8MNtMxBbX4WEskNtiyBXBLaL8 b9oqzBV1bR7Yb+Def9sug5a4r65Af5MEGgNFMJotdaslsrM0MF2z17YIkmPXciA+Yst8MSsm7ZMu TKDAQobXSmHwgeTqwRL291+9UZxE/pl6FetTs3PJrGHuFcc6wXvJ2v07nHthOToKixOE9o9bsP8A CqNVff8Y80Z+CG2zEH0hpfPPWfR084wyz0yUjiMIHsTNQj99JJVAkSxiBx6R2MKLJ7BM1E4YBC3l zy+0HVShQh2SRE898dBjTz763IOPhYywdYlA7qR4EDxLJVQjQf406WST/UQpJT9U7rOPPvnkgw8+ 93Rpz5f1hEmPPgyx80WGB7mjjTbbrKlNNtmUwuY23Gxj5512csNNN3z26Y0333wDzqDghBOOOIiO Mw455JRjjjnn1MMQOpig+VArAAYDjKbAdArgMUw5I42lBEq0zS6klsqRfqpmdJZA/qy2WpEsAgGz lqwWpWPMQLHiypKvqwK7Ua/CSkRssQ4diyxCvwl03bIN7SHQMbdCy9CH/yhrLUK0yPqkP1NSKS5D t7jiSieftKKuuey6goi6677CLiPwtsLuK/gKAm+78k7iCbv2rttKIK/AYnAsCCMcCMK+PEQOOgvN mNCGC1Wz0DnwKORPNgt5s+1ATSoUJT8TkRJPQv54skgsCc1yCCIJ3SMHIKoRNIoffiR0Sh9uFHVQ P4rMEaREvdiDci+5SEzQMLx0l+Yyx4yT0DDLMJPQN84sUxpCzEyDzccV3dIN2A2dMvRRvNjijT3G zPPqStdwE8k8TNFCSSmD7DFJ/kpkCzSyPvrsQ3LfhBdu+OGIg5y4Q9QsPlC3jv8zC+L9OCjQ5Ihf F80jMcFCSt/93HT5QNWgUnPfkFf2y+Gp/wNPjIVjPlAoFBPe+j/ZGGk7Qp99bM9JAt3+zzGNfIzM WP88UwlC/RziM7DOvEHmP++cHHxCseAmrD6ITH+Q8P8sw0mx+2Sy9fcJwcMJMN8AKw4lgx90rIK0 +spPJ9gSdGw53Miyj6/7cET8CAI+gTgDF+MwBznEkbFS8aML+RjI8wr4j3s0I0/d4FtuvhGJwTUD ctBY3kJq948l5cYavZjeOdbBK4ZQ4xwDMeFq+JEJ7+kPIfkbm0BMoap+SOJ8/gRsiDE+dDomXekf D8NGM9QDlHEEYoCPa4g3tCGVIvbjD4igRCcGAYo4DEMWp9DdTs7hCBtGsSHg4FgR/QEOcoSjG984 RzfiAQ9yaK8h+avIPrRwj4RoayDb8Ic6hEHIAHGHO8NIZCKJEY2gOMMR/xMI3UbnEHq4xoFSiCAS NyEQvEikGslQFT8MMb12uGMgsnPINkRXn31IwYyUfMg+mJgRf0RSIPC4hzz6qBF+7EGT6JsIOPQE sYq4YxSYsEUxfDEKRtyCZRrxBi2AiMqMeOwg35KSNucxjF3QYhnXmEY4rLEOK5nznIJjyDIuAct/ UJAh4uiTPPWkJz79KVD4/synPvVJqHDIhyHUrCZJQoYYezQyloXjhpGeEZvD9QNb7+xbKhM3UcRV 9HAXNVxGY4e4eFyGHJ873DpcIRBwIM9xESXbKrBxjWpMQxrPcEYzZNqMZSgDGcYoBjF2SoxECgMY v/AFL3Shi1wYtai4SKpSjarUWyj1qUm1RVNvQVWq1iKpTkuIOwC1inA4Ch3oSIdY1bGOVLwDHvGY h1rVSo9c2MNHPBKcuIDBD2066R/5GJDiBCJD01Bkkgp5G0J+tBBgJuSWCEHsQRS7EX9QKSE8aqd3 fJQ+drCSIPaQh9ESgo+3ToQXm+VWHHKGkFfQ4Q4J4UcjxHBSggiiDXKAZMgc2mA5grQDEGKwikRI 8Q6FaEMa00gIMa7BMYTcIxzYIEf62vHPg4SDG97I4z/4wSYYRg47jgjpUe6xo39INiTuEETxmBKK Q+SCFopAxiVVIo5ExEa6NUHHL5ihi13YAhk1CQgAOw== ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/ge.gif R0lGODlhCwAKALMAAAAAAP////////////////////////////////////////////////////// /////yH5BAEAAAEALAAAAAALAAoAAAQVMMhJJagYaFw3n9rViSPnfWgQrlsEADs= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #333; PADDING-TOP: 0px; BACKGROUND-COLOR: #fff } H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DT { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .txt { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } FIELDSET { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; BORDER-TOP-STYLE: none! = important; PADDING-TOP: 0px! important; BORDER-RIGHT-STYLE: none! = important; BORDER-LEFT-STYLE: none! important; BORDER-BOTTOM-STYLE: = none! important } LEGEND { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.25em 0px 0.25em 1.25em; PADDING-TOP: 0px } DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .homepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .homepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .homepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .HomepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .HomepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .HomepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .HomepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } .HomepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } TABLE.menuIEFOUR { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; MARGIN: 0px; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURSIDE { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } TABLE.menuIEFOUR TD { FONT-WEIGHT: bold; FONT-SIZE: 70%; PADDING-BOTTOM: 0.2em; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; FONT-WEIGHT: normal; COLOR: white; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { FONT-WEIGHT: bold; FONT-SIZE: 0.7em; TEXT-TRANSFORM: uppercase; COLOR: = #6089b2; FONT-STYLE: normal } H3.navigationHeader EM { FONT-SIZE: 1.1em; COLOR: #ff9b06; FONT-STYLE: normal } .homepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .HomepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .homepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .HomepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-REPEAT: repeat-y; BACKGROUND-COLOR: #13709d } UL.menuDOM LI { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: none; PADDING-BOTTOM: = 0.2em; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; BACKGROUND: white; = PADDING-BOTTOM: 0px; COLOR: white; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM LI UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuIEMAC { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM A { PADDING-RIGHT: 0.1em; DISPLAY: block; PADDING-LEFT: 0.1em; FONT-WEIGHT: = bold; PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } LI.nosaved EM { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuDOM LI UL { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover UL { BORDER-RIGHT: #90d7ff 1px solid; BORDER-TOP: #90d7ff 1px solid; = DISPLAY: block; BACKGROUND: white; LEFT: auto; MARGIN-LEFT: -1.25em; = BORDER-LEFT: #90d7ff 1px solid; WIDTH: 200px; BORDER-BOTTOM: #90d7ff 1px = solid; TOP: auto; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-RIGHT: 5px; MARGIN-TOP: 0px! important; DISPLAY: block; = PADDING-LEFT: 5px; FONT-WEIGHT: bold; BACKGROUND: #ff9900; = PADDING-BOTTOM: 5px; WIDTH: 190px; COLOR: white! important; PADDING-TOP: = 5px; voice-family: inherit } LI.nosaved EM { FONT-WEIGHT: normal! important; COLOR: black! important; = TEXT-DECORATION: none! important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none! important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } .domArrowOut { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { DISPLAY: inline; PADDING-BOTTOM: 3px } UL.menuIEMAC LI UL { LEFT: -999em; POSITION: absolute } UL.menuIEMAC { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif)!= important; PADDING-BOTTOM: 0.1em; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } #user { PADDING-RIGHT: 2em; PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: = white } #mycart { PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: white } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.standards.css @import url( = http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { PADDING-LEFT: 1em; MARGIN: 0.25em 0em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-POSITION: 100% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.basic.gif); = BACKGROUND-REPEAT: no-repeat } #searchBox { BACKGROUND-POSITION: 0% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.search.gif); = BACKGROUND-REPEAT: no-repeat } #citationBox { BACKGROUND-POSITION: 0% 0%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.citation-finder.gif)= ; BACKGROUND-REPEAT: no-repeat } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { FONT-WEIGHT: bold; MARGIN: 0px; TEXT-ALIGN: right } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { COLOR: #f90; BORDER-BOTTOM: #ccc 2px solid } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { FONT-WEIGHT: normal; TEXT-ALIGN: left } #contentFrame .mainCol #footer { BORDER-TOP: #ccc 2px solid; MARGIN: 10px 10px 0px; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 7px; MARGIN: = 0px 0px 15px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 0px; = PADDING-BOTTOM: 10px; BORDER-LEFT: medium none; PADDING-TOP: 10px } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { MARGIN-TOP: 1px; BORDER-BOTTOM: #cce5ff 1px solid } #contentFrame .sideCol #citationBox .item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 0px 10px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .sideCol #relatedProducts UL { MARGIN-TOP: 0px; PADDING-BOTTOM: 8px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { PADDING-RIGHT: 0.5em; TEXT-ALIGN: right } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { FONT-WEIGHT: bold; COLOR: #9cf; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= WIDTH: 100%; BACKGROUND-REPEAT: repeat-y } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; WHITE-SPACE: nowrap } #personalnavSpecial { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0.5em; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-RIGHT: #069 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: #069 2px = solid; PADDING-LEFT: 2px; FONT-SIZE: 11pt; PADDING-BOTTOM: 2px; = BORDER-LEFT: #069 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #069 2px = solid; FONT-FAMILY: arial } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { LINE-HEIGHT: 140%; TEXT-ALIGN: center } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.home.jpg); = BACKGROUND-REPEAT: no-repeat } #logoCell { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.jpg); = BACKGROUND-REPEAT: no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; FONT-WEIGHT: bold; COLOR: #666 } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; BORDER-LEFT: = red 1px solid; BORDER-BOTTOM: red 1px solid; BACKGROUND-COLOR: #fcc } #browserWarning { BORDER-RIGHT: #c00 1px solid; PADDING-RIGHT: 0.3em; BORDER-TOP: #c00 = 1px solid; PADDING-LEFT: 0.3em; FONT-SIZE: 100%; PADDING-BOTTOM: 0.3em; = MARGIN: 5px 28px; BORDER-LEFT: #c00 1px solid; COLOR: #300; PADDING-TOP: = 0.3em; BORDER-BOTTOM: #c00 1px solid; FONT-FAMILY: arial; = BACKGROUND-COLOR: #fef } .invisible { OVERFLOW: hidden; WIDTH: 0px; POSITION: absolute; HEIGHT: 0px } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { FLOAT: left; MARGIN: 10px } .linkPrint { FLOAT: right; MARGIN: 10px 20px 0px 0px } .linkTop { CLEAR: both; TEXT-ALIGN: right } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { FONT-WEIGHT: bold; COLOR: #c00 } #errorList LI { FONT-WEIGHT: bold; COLOR: #c00! important; LIST-STYLE-TYPE: none } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #contentFrame #intro .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; PADDING-BOTTOM: 6px; MARGIN: = 10px 0px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { PADDING-LEFT: 2em; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -2em } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 8px; COLOR: #000; LINE-HEIGHT: = 150%; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalReferences .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { MARGIN: 0px; TEXT-ALIGN: center } #contentFrame #content .issueNav SPAN { FONT-WEIGHT: bold; COLOR: #f90 } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px 0.5em; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #ccc 1px solid } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-LEFT: 6px; PADDING-BOTTOM: 10px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none! important } .journalArticleMain #intro .item { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px! important } .journalArticleMain #searchBox { BORDER-RIGHT: #99c2d6 1px solid; WIDTH: 150px } .journalArticleMain #intro #searchBox .item { PADDING-RIGHT: 10px! important; PADDING-LEFT: 10px! important; = PADDING-BOTTOM: 10px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #565565; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #content .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content .prerendered TABLE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TH { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT A { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT[size=3D'+1'] { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #666 } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-WEIGHT: bold; FONT-SIZE: 14px } #contentFrame #content .prerendered FONT[size=3D'4'] A { FONT-SIZE: 14px; COLOR: #090 } #contentFrame #content .prerendered P { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; TEXT-TRANSFORM: = uppercase; COLOR: #f90 } .prerendered .firstLevelHeading { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .secondLevelHeading { DISPLAY: block; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { FONT-SIZE: 10pt; COLOR: #369 } .prerendered .referenceNum { FONT-SIZE: 10pt; COLOR: #369 } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/links.js // These are the JavaScript functions required for outbound linking from =0A= // Wiley InterScience. (AID April 2000)=0A= // Approach copied from Andy's SFX js.=0A= // ChrisNS 20020320 - added setEarlyView()=0A= =0A= //version check=0A= var version =3D 1;=0A= var appname =3D "";=0A= var artDOI =3D "";=0A= var artEarlyView =3D "EVIEW=3DY"; // EarlyView defaults to Y=0A= var artEnableISI =3D "ENABLEISI=3DN"; //Enable ISI linking from journal = articles=0A= var artTurnOnCas =3D "ENABLECAS=3DY"; // Turn on CAS linking=0A= var artEnablePubMed =3D "ENABLEPM=3DY"; // Turn on PubMed linking=0A= =0A= if (navigator.appName.indexOf("Netscape") >=3D 0) { appname =3D "ns"; }=0A= else if (navigator.appName.indexOf("Explorer") >=3D 0) { appname =3D = "ie"; }=0A= if (navigator.userAgent.indexOf("Mozilla/2") >=3D 0) {=0A= version =3D 2;=0A= } else if (navigator.userAgent.indexOf("Mozilla/3") >=3D 0) {=0A= version =3D 3;=0A= } else if (navigator.userAgent.indexOf("Mozilla/4") >=3D 0) {=0A= version =3D 4;=0A= } else if (navigator.userAgent.indexOf("Mozilla/5") >=3D 0) {=0A= version =3D 5;=0A= }=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Get the cookies named "REF_LNX and SRC_LNX"... deprecated for now. = Always set.=0A= // Instead set the hypertext for linking.=0A= //var anchorString =3D ' 3D"extended

3D"extended

';=0A= var anchorString =3D 'Links';=0A= var targString =3D ' target=3D_top';=0A= var anchor2 =3D 'links';=0A= =0A= //NEW for special content linking. Anchor string must be taken from SGML.=0A= var contAnchor =3D '';=0A= =0A= // Linking functions=0A= =0A= =0A= //Get the EarlyView flag of the citing article which is needed to ensure = that the link is suitable for ISI WoS.=0A= // The CONTROL details are passed in, in the form -----. only grab the = 2nd of 5 characters which is the EarlyView flag=0A= function setEarlyView(object)=0A= {=0A= if ((version >=3D 3) && (object.substring(1,2) !=3D "Y"))=0A= {=0A= artEarlyView =3D "EVIEW=3DN"; =0A= }=0A= }=0A= =0A= //Get the DOI of the citing article which is needed for the ISI links.=0A= function setDOI(object){=0A= if (version >=3D 3)=0A= {=0A= artDOI =3D object;=0A= }=0A= }=0A= =0A= function setISSN(object)=0A= {=0A= }=0A= =0A= // Print out the reference link. =0A= function print_link(object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= // remove "BIB" prefix from the value of BIBID (for ISI linking)=0A= // note, this could be performed in LNX. Need to reassess where this = should be done.=0A= var re =3D new RegExp ('BIBID=3DBIB', 'i') ;=0A= var paramstring =3D new String();=0A= paramstring =3D object.replace(re, 'BIBID=3D');=0A= =0A= var unpCookie =3D '/cgi-bin/reflink?object=3D' + escape(paramstring = + "&" + artDOI + "&" + artEarlyView + "&" + artEnableISI + "&" + = artTurnOnCas + "&" + artEnablePubMed);=0A= if (netscape4 =3D=3D false)=0A= {=0A= document.write ('' + anchorString + ' ');=0A= }=0A= else // protect against inline style application hanging NN4=0A= {=0A= document.write ('' + = anchorString + ' '); =0A= }=0A= }=0A= else=0A= {=0A= document.writeln();=0A= } =0A= }=0A= =0A= //Print out source links (in the citing article)=0A= function print_SRClink(object){=0A= if (version >=3D 3)=0A= {=0A= var unpCookie =3D '/cgi-bin/srclink?object=3D' + escape(object);=0A= var url =3D unpCookie;=0A= document.write ('

Find = other ');=0A= document.write (anchor2.link(url));=0A= document.write (' for this article.

');=0A= }=0A= else=0A= {=0A= document.writeln();=0A= } =0A= }=0A= =0A= // Links for journal citations=0A= function print_JCIT(object)=0A= {=0A= if (object.match(/JTL/) !=3Dnull)=0A= {=0A= print_link(object); =0A= } =0A= }=0A= =0A= // Links for book citations=0A= function print_BKCIT(object){=0A= }=0A= =0A= // Links for electronic path citations=0A= function print_EPATHCIT(object){=0A= }=0A= =0A= // Links for patent citations=0A= function print_PATENTCIT(object){=0A= }=0A= =0A= // Links for standard citations=0A= function print_STANDARDCIT(object){=0A= }=0A= =0A= // Links for other citations, e.g., theses, proceedings, personal = communications=0A= function print_OTHERCIT(object){=0A= }=0A= =0A= //NEW functions for special content linking. (AID Sept 5 2000)=0A= =0A= // print an anchor with the specified text and calling linking program.=0A= =0A= function print_contentlink_start(conttext, object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= if (object.match(/URL/) !=3D null || object.match(/ACC/) !=3D null)=0A= {=0A= object =3D object + "&TEXT=3D" + conttext;=0A= var unpCookie =3D '/cgi-bin/contlink?object=3D' + escape(object);=0A= document.write ('');=0A= }=0A= }=0A= document.writeln();=0A= =0A= }=0A= =0A= function print_contentlink_end(object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= if (object.match(/URL/) !=3D null || object.match(/ACC/) !=3D null)=0A= {=0A= document.write('');=0A= }=0A= } =0A= document.writeln();=0A= =0A= }=0A= =0A= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/96516027/FIGJS =0A= =0A= function newfigwin() {var hwnd =3D window.open('', 'Figures', = 'dependent=3D0,toolbar=3D1,location=3D0,status=3D0,menubar=3D0,scrollbars= =3D1,resizable=3D1,width=3D600,height=3D400'); return hwnd; } =0A= function pagetitle() {return 'Cancer Vol.95, 2 Pages: 249-257'; } =0A= function dochead(hwnd, spec) {var title =3D pagetitle(); = hwnd.document.open(); = hwnd.document.write(''+spec+title+''); } =0A= function doctail(hwnd) {hwnd.document.write(''); } =0A= function pagehead(hwnd) {hwnd.document.write('

3D"About

Online ISSN: 1097-0142 Print ISSN: = 0008-543X
Cancer
Volume 95, Issue 2, 2002. Pages: 249-257

Copyright © 2002 American Cancer = Society

'); } =0A= function copyright(hwnd) {var title =3D pagetitle(); = hwnd.document.write(title.bold() + '
Copyright © 2002 American = Cancer Society

'); } =0A= function imagelink(hwnd, iname) {hwnd.document.write('

'); } =0A= function otherlinks(hwnd, iname, size) {hwnd.document.write('View Normal Image '); else = hwnd.document.write('(1) target=3Dmain >View Magnified Image '); = hwnd.document.write('View List of Images '); hwnd.document.write('

'); } =0A= function caption_fig001(hwnd) { hwnd.document.write('Figure 1. Kaplan-Meier A) progression free and B) overall survival curves in = glioblastoma patients with mutated (black line, n =3D 17) or intact = (gray line, n =3D 38) p53 (P > 0.05 in both A and = B).
'); } =0A= function gcaption_fig001(hwnd) { hwnd.document.write('American Cancer Society

'); } =0A= function display_fig001(size) { var i =3D new Array(); i[0] =3D = 'nfig001'; i[1] =3D 'mfig001'; var hwnd =3D newfigwin(); dochead(hwnd, = ''); copyright(hwnd); otherlinks(hwnd, 'fig001', size); imagelink(hwnd, = i[size]); gcaption_fig001(hwnd); caption_fig001(hwnd); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= function caption_fig002(hwnd) { hwnd.document.write('Figure 2. Kaplan-Meier A) progression free and B) overall survival curves in = patients with diffuse astrocytoma (n =3D 15), anaplastic astrocytoma (n = =3D 23), and glioblastoma (n =3D 55) with mutated (n =3D 31) or intact = (n =3D 62) p53 (P > 0.05 in both A and B).
'); } =0A= function gcaption_fig002(hwnd) { hwnd.document.write('American Cancer Society

'); } =0A= function display_fig002(size) { var i =3D new Array(); i[0] =3D = 'nfig002'; i[1] =3D 'mfig002'; var hwnd =3D newfigwin(); dochead(hwnd, = ''); copyright(hwnd); otherlinks(hwnd, 'fig002', size); imagelink(hwnd, = i[size]); gcaption_fig002(hwnd); caption_fig002(hwnd); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= function imagelist() {var hwnd =3D newfigwin(); dochead(hwnd, 'List of = Images - '); copyright(hwnd); hwnd.document.write(''); hwnd.document.write(''); hwnd.document.write(''); hwnd.document.write('

	'); caption_fig001(hwnd); = hwnd.document.write(' [Normal View 17K \| Magnified View = 30K]

	'); caption_fig002(hwnd); = hwnd.document.write(' [Normal View 16K \| Magnified View = 29K]

'); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= ------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/96516027/main.html,ftx_abs Wiley InterScience = :: Article Full Text HTML

Cancer

3D"RSS What=20 is RSS?

Volume 95, Issue 2, Pages 249-257

Published Online: 11 Jul 2002

Copyright =A9 2002 American Cancer Society

3D"Journal

3D"E-Mail

3D""=20

< Previous Article | Next Article=20 >

Save Article to My Profile=20 Download Citation=20

Abstract | References | Full Text: = HTML , PDF (116k)=20

View Full Width

3D""=20

3D""=20

Original Article

Influence of p53 = mutations on=20 prognosis of patients with glioblastoma

Shoji Shiraishi, M.D.^{1=20
*}, Kenji Tada, M.D.^=
1,=20 Hideo Nakamura, M.D., Ph.D.^=
1,=20 Keishi Makino, M.D., Ph.D.^=
1, Masato=20 Kochi, M.D., Ph.D.¹, = Hideyuki Saya,=20 M.D., Ph.D.², Jun-ichi = Kuratsu,=20 M.D., Ph.D.³, Yukitaka = Ushio, M.D.,=20 Ph.D.¹

¹Department of = Neurosurgery,=20 Kumamoto University Medical School, Kumamoto, = Japan
²Department of Tumor Genetics and = Biology,=20 Kumamoto University Medical School, Kumamoto, = Japan
³Department of Neurosurgery, Faculty = of=20 Medicine, Kagoshima University, Kagoshima, = Japan

email: Shoji Shiraishi (sshira@fc.kumamoto-u.ac.jp= )

^*Correspondence to Shoji = Shiraishi,=20 Department of Neurosurgery, Kumamoto University Medical School, = 1-1-1=20 Honjo, Kumamoto 860-8556, Japan

Fax: +81-96-371-8064

Conference: 14th International Conference on Brain Tumor = Research and Therapy, North Carolina, 27 May 2001 to 30 May = 2001.

Funded by:
Ministry of Education, Sports, Science, and = Culture of=20 Japan

Keywords

p53 =95 astrocytoma =95 glioblastoma =95 yeast functional = assay =95=20 prognosis =95 tumorigenesis

Abstract

3DAbstract=20

BACKGROUND

The influence of p53 mutations on the biology of=20 astrocytic tumors is controversial. p53 is thought to = be=20 inactivated in the early stage of gliomagenesis; however, = what role=20 its inactivation plays in the malignancy of gliomas remains = unknown.=20 To understand the significance of p53 inactivation, = the=20 authors identified the locus of p53 gene mutation in = glioma=20 samples at different stages of progression and studied the=20 correlation between the mutation and clinical = behavior.

METHODS

Samples from newly diagnosed gliomas, including pure and = mixed=20 astrocytomas, were analyzed for p53 mutations using a = yeast=20 functional assay. To determine the locus of the gene = mutations, DNA=20 sequencing was performed.

RESULTS

The incidence of p53 mutations was higher in = anaplastic=20 astrocytomas (AA, 48%) than glioblastomas (GBM, 31%). There = was no=20 significant difference in the average ages of GBM patients = with and=20 without p53 mutations (54.9 years =B1 2.3 and 53.2 = years =B1 4.6,=20 respectively). In GBM patients, the mutation did not affect=20 progression free survival or overall survival. Astrocytomas = and GBM=20 differed in the distribution of p53 mutation = loci.

CONCLUSIONS

The p53 gene mutation does not markedly affect the=20 survival of GBM patients. The difference in the location of=20 p53 mutations between AA and GBM suggests that in = gliomas,=20 the p53 mutation may contribute not only to = tumorigenesis (as=20 an early event) but also to progression to malignancy (as a = late=20 event). Cancer 2002;95:249-57. =A9 2002 American Cancer = Society.

DOI 10.1002/cncr.10677

Received: 17 October 2001; Revised: 30 January 2002; Accepted: 15 = February=20 2002

Digital Object Identifier=20 = (DOI)

10.1002/cncr.10677 = ; About=20 DOI

Article=20 Text

Astrocytic tumors are the most common adult neoplasms of the = central=20 nervous system. They have been classified into four = clinico-pathologic=20 groups: pilocytic- (PA), diffuse- (DA), and anaplastic astrocytoma = (AA),=20 and glioblastoma multiforme (GBM).[1]=20 However, PA is thought to be clinically and genetically distinct = from the=20 other astrocytic tumors.[2][3]=20 In addition, GBMs have been divided into two subgroups based on = clinical=20 and biologic features. Primary GBMs arise de novo, while secondary = GBMs=20 are the result of progression from lower grade astrocytomas. These = tumors=20 can now be characterized by their molecular genetic backgrounds. = Some have=20 suggested that primary and secondary GBMs are distinct disease = entities=20 that evolve via different genetic pathways.[4][5]=20 Primary GBMs are characterized by amplification/overexpression of=20 epidermal growth factor receptor (EGFR),[6][7]=20 homozygous deletion of p16,[8][9]=20 amplification/ overexpression of murine double minute 2 (MDM2),[10][11]=20 and the entire loss of chromosome 10.[12]=20 Secondary GBMs are characterized by functional loss of TP53 mainly = caused=20 by the gene mutations[13][14]=20 and partial or complete loss of chromosome 10q.[12]=20 As the p53 gene mutation has been shown to occur in the = early stage=20 of progression to secondary GBM,[14][15-19]=20 it can presumably be present in astrocytic tumors of different = stages.=20 Whether the mutation affects sensitivity to therapy and prognosis = remains=20 controversial.[20-27]=20 To clarify whether p53 mutations affect the clinical = biology of=20 these tumors, we explored the p53 status of 123 surgical = specimens=20 using a well-established yeast functional assay. Mutations of the=20 p53 gene were identified by DNA sequencing.

MATERIALS AND=20 METHODS

3D"MATERIALS

Patients and = Tissue=20 Specimens

The samples analyzed in the current study were obtained from = the=20 Department of Neurosurgery at Kumamoto University Hospital, = Kumamoto,=20 Japan, and its affiliated hospitals. They were from newly = diagnosed,=20 consecutive patients treated between 1995 and 2000. There were 73 = males=20 and 50 females ranging in age from 0 to 78 years (mean, 45 years). = The=20 patients and/or their legal guardians gave written informed = consent for=20 use of their specimens. Tumor specimens were obtained by surgical=20 resection (including biopsy), quickly frozen, and kept at -80 =B0C = until=20 use. Formalin-fixed, paraffin-embedded specimens were subjected to = histopathologic examination. Each specimen was classified = according to=20 established World Health Organization criteria.[1]=20 The presence or absence of high cellularity, nuclear atypia, = mitoses,=20 microvascular proliferation, and necrosis were recorded. The = presence of=20 necrosis and/or microvascular proliferation was used as major = criteria to=20 distinguish between GBMs and AAs. There were 9 PAs, 15 DAs, 23 = AAs, 55=20 supratentorial GBMs, 4 brain stem GBMs, 2 giant cell = glioblastomas, 1=20 oligoastrocytoma, and 14 anaplastic oligoastrocytomas. All = patients=20 underwent surgical resection (including biopsy) with or without=20 postoperative radiotherapy and/or nitrosourea-based chemotherapy. = Most GBM=20 patients younger than 70 years received both radio- and = chemotherapy;=20 older patients usually underwent only radiotherapy. To determine = the=20 extent of surgical resection we performed postoperative magnetic = resonance=20 imaging (MRI) study. Total resection was recorded when there were = no=20 residual lesions, subtotal resection when less than 10% of the=20 preoperative mass remained, and partial resection when more than = 10% of=20 the mass remained. For analysis, subtotal and partial resections = were=20 combined into the subtotal resection group. All patients were = reevaluated=20 after receiving initial adjuvant therapy; at periodical followup = visit,=20 MRI was performed. Clinical details, including the Karnofsky = performance=20 status (KPS) at the time of diagnosis, the extent of surgery, date = of=20 recurrence (or regrowth) on MRI, and date of death were = recorded.

mRNA Extraction = and Reverse=20 Transcriptase Polymerase Chain Reaction

The mRNA was extracted from the frozen tissue samples using the = Quick=20 Prep Micro mRNA Purification Kit (Amersham Pharmacia Biotech, = Piscataway,=20 NJ), and random hexamer-primed single-strand cDNA was synthesized = using=20 the SUPERSCRIPT Preamplification System (Life Technologies, = Rockville, MD)=20 according to the manufacturer's instructions. To amplify the = p53=20 cDNA, polymerase chain reaction (PCR) was performed in 25 L of reaction mixture containing 2.5 = L of 10 X Pfu buffer (Stratagene, La = Jolla, CA),=20 1.25 units of Pfu polymerase (Stratagene), 100 ng of each primer, = 50 M of dNTPs, and 10% (vol/vol) = dimethyl sulfoxide=20 using a Thermal Cycler (Perkin-Elmer, Norwalk, CT) for 5 minutes = at 94 =B0C,=20 for 35 cycles of 40 seconds at 94 =B0C, 70 seconds at 65 =B0C, 90 = seconds at=20 78 =B0C; then for 8 minutes at 78 =B0C. The p53 specific = primers for a=20 1 kb fragment encompassing codons 53-364 (exons 4-10) were P3 = (5-ATT TGA TGC TGT CCC CGG ACG ATA TTG AAsC-3, where s represents a phosphorothioate linkage) and P4 = (5-ACC CTT TTT GGA CTT CAG GTG GCT GGA GTsG-3.[28]

Yeast = Functional=20 Assay

To investigate the p53 gene status in various glioma = subtypes,=20 we performed a yeast functional assay as previously described.[28]=20 Briefly, the p53 PCR product and linearized = p53-expression=20 vector pSS16 were co-transfected into the reporter yeast strain = yIG397,=20 using the lithium acetate procedure. The transformed yeast cells = were=20 plated, incubated at 30 =B0C for two days to generate colonies, = and stored=20 at 4 =B0C overnight to develop color. At least 200 colonies were = examined=20 for each plate. When more than 15% of the colonies were red, we = judged the=20 sample positive for p53 functional loss and proceeded to = sequencing=20 analysis.

DNA = Sequencing

To examine possible effects of p53 mutations in gliomas, = we=20 performed DNA sequencing on samples judged positive for the = mutation.=20 Eight red colonies from each positive plate were randomly picked = and=20 p53 fragments were amplified by direct PCR with P3 and P4 = primers,=20 using rTth polymerase (PE Applied Biosystems, Foster City, CA). = The PCR=20 products were separated on an 0.8% agarose, then the DNA bands = were=20 excised and purified using a QIAquick Gel Extraction Kit (QIAGEN, = Hilden,=20 Germany) according to the manufacturer's instructions. Sequencing=20 reactions were performed with P3 and P4 primers using a Big Dye = Terminator=20 Cycle Sequencing Kit (PE Applied Biosystems). The sequencing = instrument=20 was an ABI377 automated sequencer (PE Applied Biosystems).

Statistical=20 Analysis

Few patients with GBM, the most malignant glioma subtype, are = treated=20 successfully. To clarify whether p53 gene mutations = contribute to=20 the malignancy of GBM, we analyzed the association between = p53=20 status and clinical parameters in adult patients with cerebral = GBM.=20 Progression free survival (PFS) and overall survival (OS) were = calculated=20 from the day of surgery to the day of recurrence or death. We used = the=20 student t test to evaluate the relationship between = p53=20 status and age and the chi-square test to determine the = relationship=20 between p53 status and gender. The effect of different = parameters,=20 i.e., age (54 vs 55), gender, preoperative KPS (60 vs 70), extent = of=20 surgical resection (total vs subtotal/biopsy), and p53 = mutation=20 status (intact vs mutated), on the Kaplan-Meier survival curve of = PFS or=20 OS was analyzed using the log rank (Mantel-Cox) test. The = independent=20 effect of each parameter on PFS and OS was analyzed using the = multivariate=20 Cox proportional hazards regression model. Also, to clarify the = overall=20 effect of p53 status on clinical behavior regardless of = tumor=20 grade, we performed the same survival analyses on the entire = patient=20 population, including DA, AA, and GBM. All calculations were = performed=20 using Statview statistical software (Version 5.0; Abacus Concepts, = Inc.,=20 Berkeley, CA). P values lower than 0.05 were considered=20 significant.

RESULTS

3DRESULTS=20

p53 = Mutations and=20 Statistical Analyses in GBM Patients

Clinical data and the results of mutation analysis are = summarized in=20 Table 1.=20 p53 mutations were present in 48% of AAs and 31% of = supratentorial=20 GBMs; they were less frequent, or absent, in the other subtypes. = The ages=20 of GBM patients with and without p53 mutations were 53.2 = =B1 4.6 and=20 54.9 =B1 2.3 years, respectively; there was no significant = difference in age=20 or gender between these two groups. The median survival of GBM = patients=20 carrying the mutation was 69.7 =B1 16.2 weeks; it was 71.2 =B1 3.4 = weeks for=20 GBM patients with normal p53, and the difference was not=20 statistically significant. p53 mutations had no influence = on PFS or=20 OS not only in GBM (Fig. 1)=20 but also in overall astrocytic tumors, including low grade and = anaplastic=20 astrocytomas (Fig. 2);=20 OS was longer in younger patients (=20 54) and those with a higher KPS (70 ;=20 P =3D 0.003 and P =3D 0.017, respectively; Tables 2=20 and 3).=20

Figure 1. Kaplan-Meier = A)=20 progression free and B) overall survival curves in = glioblastoma=20 patients with mutated (black line, n =3D 17) or intact (gray = line, n =3D=20 38) p53 (P > 0.05 in both A and B).
[Normal View 17K | = Magnified View=20 30K]

Figure 2. Kaplan-Meier = A)=20 progression free and B) overall survival curves in patients = with=20 diffuse astrocytoma (n =3D 15), anaplastic astrocytoma (n = =3D 23), and=20 glioblastoma (n =3D 55) with mutated (n =3D 31) or intact (n = =3D 62)=20 p53 (P > 0.05 in both A and B).
[Normal View 16K | = Magnified View=20 29K]

Table 1. Genetic Status and = Clinical=20 features of Patients with Glioma

No.	Age in = years	Gender	WHO = Class	WHO = Grade	p53 = Mutation	KPS	Resect
Mutation	Exon	Codon	Base change	AA change

1	2	M	PA	1	N
2	9	F	PA	1	N
3	20	M	PA	1	N
4	8	M	PA	1	N
5	6	M	PA	1	N
6	9	F	PA	1	N
7	6	M	PA	1	N
8	6	M	PA	1	N
9	36	M	PA	1	N
10	43	F	DA	2	N					90	total
11	48	M	DA	2	N					100	subtotal
12	62	M	DA	2	N					100	subtotal
13	4	M	DA	2	N					90	total
14	43	F	DA	2	N					100	subtotal
15	50	M	DA	2	N					80	subtotal
16	78	M	DA	2	N					80	biopsy
17	70	M	DA	2	N					90	biopsy
18	35	M	DA	2	N					80	subtotal
19	23	M	DA	2	N					80	biopsy
20	0	F	DA	2	N					90	total
21	41	F	DA	2	N					NR	subtotal
22	60	F	DA	2	P	6	220	tat to tgt	Y to C	100	total
23	62	M	DA	2	P	8	273	cgt to tgt	R to C	100	subtotal
24	39	M	DA	2	P	8	273	cgt to tgt	R to C	100	total
25	38	F	AA	3	N					100	NR
26	62	M	AA	3	N					70	biopsy
27	26	M	AA	3	N					70	subtotal
28	43	M	AA	3	N					NR	NR
29	43	M	AA	3	N					100	biopsy
30	72	M	AA	3	N					100	subtotal
31	50	F	AA	3	N					70	subtotal
32	68	F	AA	3	N					90	total
33	20	M	AA	3	N					70	subtotal
34	35	M	AA	3	N					100	subtotal
35	43	F	AA	3	N					100	total
36	26	M	AA	3	N					90	biopsy
37	54	F	AA	3	P	6	213	cga to caa	R to E	70	subtotal
38	41	M	AA	3	P	7	248	cgg to cag	R to Q	100	total
39	43	F	AA	3	P	7	261	agt to agg	S to R+ ins.	100	subtotal
40	40	M	AA	3	P	8	264	cta del.	L del.	100	subtotal
41	18	F	AA	3	P	8	273	cgt to cat	R to H	70	total
42	31	M	AA	3	P	8	273	cgt to tgt	R to C	100	subtotal
43	42	F	AA	3	P	8	273	cgt to tgt	R to C	90	biopsy
44	29	M	AA	3	P	8	273	cgt to cat	R to H	100	subtotal
45	56	F	AA	3	P	8	273	cgt to tgt	R to C	100	total
46	37	F	AA	3	P	8	280	aga to gga	R to G	20	subtotal
47	48	M	AA	3	P	8	280	aga to aaa	R to K	100	subtotal
48	54	M	GBM	4	N					70	total
49	69	F	GBM	4	N					80	subtotal
50	56	M	GBM	4	N					90	total
51	53	F	GBM	4	N					70	subtotal
52	54	F	GBM	4	N					50	subtotal
53	71	F	GBM	4	N					70	subtotal
54	75	F	GBM	4	N					60	total
55	66	F	GBM	4	N					100	subtotal
56	51	F	GBM	4	N					50	subtotal
57	63	F	GBM	4	N					100	subtotal
58	45	M	GBM	4	N					100	total
59	74	F	GBM	4	N					60	total
60	54	M	GBM	4	N					70	subtotal
61	29	F	GBM	4	N					70	biopsy
62	25	M	GBM	4	N					60	subtotal
63	59	M	GBM	4	N					90	biopsy
64	54	M	GBM	4	N					70	subtotal
65	51	F	GBM	4	N					90	subtotal
66	64	M	GBM	4	N					90	subtotal
67	38	F	GBM	4	N					10	subtotal
68	61	F	GBM	4	N					90	biopsy
69	47	M	GBM	4	N					90	total
70	53	M	GBM	4	N					60	subtotal
71	53	M	GBM	4	N					90	biopsy
72	45	M	GBM	4	N					70	total
73	72	M	GBM	4	N					100	subtotal
74	52	F	GBM	4	N					70	subtotal
75	40	M	GBM	4	N					80	total
76	68	M	GBM	4	N					60	subtotal
77	73	F	GBM	4	N					50	total
78	71	F	GBM	4	N					100	subtotal
79	48	M	GBM	4	N					100	total
80	64	F	GBM	4	N					70	total
81	65	M	GBM	4	N					90	subtotal
82	21	M	GBM	4	N					100	biopsy
83	61	M	GBM	4	N					70	total
84	20	F	GBM	4	N					60	total
85	69	M	GBM	4	N					80	subtotal
86	17	F	GBM	4	P	4	90 to 105	del.		100	subtotal
87	60	M	GBM	4	P	5	131	aac to del.	N to del.	70	subtotal
88	33	M	GBM	4	P	5	158	cgc to ctc	R to L	70	subtotal
89	71	M	GBM	4	P	5	175	cgc to cac	R to H	60	subtotal
90	71	M	GBM	4	P	5	179	cat to tat	H to Y	NR	subtotal
91	23	M	GBM	4	P	5	179	cat to ctt	H to L	50	biopsy
92	54	M	GBM	4	P	6	190	cct to ctt	P to L	60	total
93	23	F	GBM	4	P	6	195	atc to acc	I to T	100	subtotal
94	45	M	GBM	4	P	6	196	cga to tga	R to stop	100	total
95	47	M	GBM	4	P	7	245	ggc to agc	G to S	60	subtotal
96	77	F	GBM	4	P	7	246	atg to gtg	M to V	70	subtotal
97	74	M	GBM	4	P	7	248	cgg to tgg	R to W	80	subtotal
98	67	F	GBM	4	P	7	251	atc to ttc	I to F	90	total
99	56	F	GBM	4	P	8	267	cgg to tgg	R to W	80	subtotal
100	64	M	GBM	4	P	8	273	cgt to ggt	R to G	70	total
101	55	M	GBM	4	P	8	273	cgt to tgt	R to C	60	biopsy
102	69	F	GBM	4	P	8	282	cgg to tgg	R to W	80	subtotal
103	71	M	GBM, BS	4	N
104	53	M	GBM, BS	4	N
105	4	F	GBM, BS	4	N
106	3	M	GBM, BS	4	P	8	277	tgt to ttt	C to F
107	22	F	GGB	4	N
108	32	F	GGB	4	P	5	148	cgg to cag	R to Q
109	47	M	AOA	3	N
110	42	F	AOA	3	N
111	49	F	AOA	3	N
112	51	F	AOA	3	N
113	39	M	AOA	3	N
114		M	AOA	3	N
115	52	M	AOA	3	N
116	43	M	AOA	3	N
117	44	F	AOA	3	N
118	37	M	AOA	4	N
119	66	M	AOA	4	N
120	65	F	AOA	4	N
121	58	M	AOA	4	N
122	45	F	AOA	3	P	5	131	aac del.	N del.
123	1	M	OA	2	N

WHO: World Health = Organization;=20 AA change: amino acid change; KPS: Karnofsky performance = status;=20 Resect: extent of resection; M: male; F: female; PA: = pilocytic=20 astrocytoma; DA: diffuse astrocytoma; AA: anaplastic = astrocytoma;=20 GBM: glioblastoma multiforme; BS: brain stem; AOA: = anaplastic=20 oligoastrocytoma; OA: oligoastrocytoma; GGB: giant cell=20 glioblastoma; N: negative; P: positive; del: deletion; ins:=20 insertion; stop: stop codon; NR: not=20 recorded.

Table 2. Univariate Analysis for=20 Prognosis Factors in GBM

Characteristic	No. of = cases	PFS	OS
Median =B1 SE = (weeks)	P values	Median =B1 SE = (weeks)	P = values

Age	54	27	14.4 =B1 3.6	0.869	80.3 =B1 7.7	0.018
	55	28	18.0 =B1 2.6		46.3 =B1 20.6
Gender	Male	31	17.5 =B1 4.7	0.863	61.4 =B1 25.0	0.390
	Female	24	17.1 =B1 6.1		71.3 =B1 3.0
KPS	60	15	9.9 =B1 1.8	0.050	50.4 =B1 10.1	0.055
	70	39	20.3 =B1 2.5		78.3 =B1 11.9
	Not recorded	1
Extent of resection = p53=20 status	Subtotal/biopsy	37	14.1 =B1 1.0	0.030	68.6 =B1 12.4	0.639
	Total	18	44.9 =B1 34.0		71.3 =B1 5.0
	Intact	38	14.4 =B1 4.1	0.364	71.2 =B1 3.4	0.925
	Mutated	17	20.3 =B1 6.6		69.7 =B1 16.2

GBM: glioblastoma = multiforme;=20 PFS: progression free survival; OS: overall survival; SE: = standard=20 error; KPS: karnofsky performance score. P values = lower than=20 0.05 were considered=20 significant.

Table 3. Multivariate Analysis = for=20 Prognosis Factors in GBM

Factor	PFS	OS
Hazard ratio	95% Confidence = interval	P values	Hazard ratio	95% Confidence = interval	P = values

Age (54 )	0.992	0.492-1.998	0.982	0.310	0.143-0.675	0.003
Gender (female)	0.726	0.338-1.559	0.412	0.652	0.305-1.397	0.271
KPS (70)	0.609	0.274-1.350	0.222	0.295	0.126-0.694	0.005
Extent of resection = (total)	0.379	0.137-1.050	0.062	1.203	0.543-2.665	0.648
p53 status = (mutated)	0.634	0.293-1.370	0.246	0.744	0.316-1.753	0.499

GBM: glioblastoma = multiforme;=20 PFS: progression free survival; OS: overall survival; KPS: = Karnofsky=20 performance score. P values lower than 0.05 were = considered=20 significant.

Sequencing=20 Analysis

Of an overall 34 mutations, 28 (82%) were missense mutations; = of these,=20 14 (50%) were located on hot spots. There was only one nonsense = mutation=20 (Patient 94, Table 1).=20 Of the 28 missense mutations, 24 (86%) were transition mutations. = There=20 was no significance in these mutational characteristics in AA and = GBM=20 (Table 4).=20 Of the 34 mutations, 4 (12%) were base deletions; one was a base = insertion=20 mutation. With respect to mutation location, 8 of 11 (73%) = p53=20 mutations in AA and 4 of 17 (24%) in GBM were located on exon 8 = (Tables 1=20 and 4);=20 the difference between AA and GBM was significant at P =3D = 0.01.=20

Table 4. Profile of Overall = Mutations in=20 Glioma

WHO class	Missense (%)	Hot spot (%)	Transition (%)	Exon 8 (%)

AA	9/11 (82)	6/9 (67)	9/9 (100)	8/11 (73)
GBM	14/17 (82)	6/14 (43)	11/14 (79)	4/17 (24)
others	5/6 (83)	2/5 (40)	4/5 (80)	3/6 (50)
total	28/34 (82)	14/28 (50)	24/28 (86)	15/34 = (44)

WHO: World Health = Organization;=20 AA: anaplastic astrocytoma; GBM: glioblastoma=20 multiforme.

DISCUSSION

3DDISCUSSION=20

The tumor suppressor p53 gene mutation is a genetic = alteration=20 often seen in astrocytic tumors, especially malignant gliomas, = including=20 AA and GBM. This mutation has been documented by single-strand=20 conformational polymorphism study,[21][22][26][29]=20 immunohistochemistry,[13][15][18][30]=20 and yeast functional assays.[28][31]

The aim of the current study was to categorize gliomas = genetically to=20 promote the development of evidence based cancer therapies. If = such=20 genetics based treatment becomes available, a patient's p53 = status=20 must be known. The yeast functional assay we employed can detect = only=20 loss-of-function mutations. However, it is simple and its results = are=20 reproducible,[31][32]=20 and we found it to be as sensitive as other assays for the = detection of=20 mutations in the p53 gene. We consider the yeast functional = assay=20 best suited for our current studies.

The influence of p53 mutations in gliomas has already = been=20 discussed.[1]=20 Tumor cells carrying p53 mutations are resistant to = apoptosis=20 induced by DNA damage, while an overexpression of wild-type = p53=20 enhances the radiosensitivity of glioma cells.[33-35]=20 However, the effect of p53 mutations on the efficacy of = radio- and=20 chemosensitivity in patients with gliomas, especially GBMs, = remains=20 controversial. Some have reported that the p53 status of = GBM=20 patients did not affect their survival[22][29]=20 or sensitivity to radiotherapy.[21]=20 Others have shown that the presence of p53 gene mutations = in GBM=20 was associated with longer survival[23][26]=20 and a better radiation response.[23]

The current data show that the time to tumor progression after = surgery=20 in patients receiving radiochemotherapy was not affected by the = presence=20 of p53 mutation. Therefore, the p53 gene mutation = alone does=20 not account for the radiochemoresistance of GBM. In fact, there is = some=20 evidence that p21 overexpression due to wild-type p53=20 overexpression results in radioresistance[36][37]=20 and chemoresistance[38]=20 in glioma, and that drug-resistance gene expressions render glioma = cells=20 chemoresistant.[39]

Diverse gene alterations are involved in glioblastoma = progression. The=20 MDM2 oncogene, whose product degrades and inactivates = p53=20 protein,[40][41]=20 is amplified and overexpressed in approximately 10% of GBMs, = particularly=20 primary GBMs with intact p53.[10]=20 Amplification of MDM2 leads to inhibition of the = tumor-suppressive=20 effects of p53. In gliomas, transcription of a short = alternative=20 splice variant of MDM2 is frequently observed.[42][43]=20 It has been reported[44]=20 that the variant lacks the ability to bind p53 protein for = its=20 degradation. This may be one explanation for the observation that = in 30%=20 of primary GBMs there is accumulation of wild-type p53 = protein. The=20 p53 mutation occurs early in the progression from low grade = diffuse=20 astrocytoma to glioblastoma.[1]=20 We posit that in secondary GBMs that manifest the mutation, the = mutation=20 may be carried over from earlier stages in tumor progression. We = found=20 that in 73% of AAs and 24% of GBMs, the p53 mutation was = localized=20 to exon 8. This suggests that AAs containing the p53 = mutation on=20 exon 8 have a lower tendency for malignant progression. If this = were not=20 the case, GBMs could be expected to have acquired new p53 = mutations=20 on exons other than exon 8 as a later event in progression to GBM. = On the=20 other hand, if the propensity for malignant progression is indeed = lower in=20 AAs with the mutation on exon 8, one could expect a lower = incidence of=20 p53 mutations in GBMs. In fact, this was not the case in = the=20 current study, where no less than 31% of GBMs manifested the = p53=20 mutation. In addition, the fact that the rate of exon 8 mutation = in DA was=20 lower than in AA is inconsistent with the first hypothesis. We = concluded=20 that some of mutations in GBM were acquired de novo.

We also found that mixed gliomas rarely contained p53 = mutations=20 (Table 1).=20 This suggests that in these tumors, the pathway for tumorigenesis = or=20 progression is different from that in pure astrocytomas. To = classify=20 gliomas genetically and to elucidate factors involved in their=20 tumorigenesis and progression to malignancy, large scale studies = must be=20 performed that also address the status of other genes, such as = MDM2,=20 p16, p14, EGFR, and PTEN.

Mechanisms upstream and downstream from the p53 tumor=20 suppressive pathway are being revealed.[40][41][45-48]=20 TP53 transactivates many target genes that are involved in various = biologic functions. Each gene has its own p53-binding = sequence in=20 its promoter and is under the control of p53 in a promoter = specific=20 manner. As we screened for the functional loss of p53 by = RGC, one=20 of the binding sequences, we were unable to detect all possible=20 mutations[49]=20 and may have overlooked some mutations resulting in the loss of = important=20 unknown promoter activities. Studies are underway to determine = whether=20 such mechanisms are impaired in gliomas.

Although we found that in AA the p53 mutation tended to = be=20 located on exon 8, this tendency may lack significance. The = current=20 finding may reflect promoter-selective transactivation. In breast=20 carcinoma, p53 mutations on exon 4 were associated with a=20 particularly poor prognosis, while mutations on exons 6 and 7 and = on hot=20 spot regions were not, suggesting that different p53 = domains may=20 affect patient survival differently.[50]=20 Further investigations may yield information on whether this is = also the=20 case in patients with glioma.

Acknowledgements

3DAcknowledgements=20

The authors thank Dr. Mitsuhiro Tada, Division of Cell Biology, = Cancer=20 Institute, Hokkaido University School of Medicine for providing = the=20 expression plasmid vector pss16 and the reporter yeast strain = yIG397.

References

3DReferences=20

1 Kleihues P, Cavenee WK. Pathology and = genetics=20 of tumors of the nervous system. Lyon: IARC Press, 2000.

2 Ishii N, Sawamura Y, Tada M, et al. Absence = of=20 p53 gene mutations in a tumor panel representative of = pilocytic astrocytoma diversity using a p53 = functional assay.=20 Int J Cancer. 1998; 76: 797-800.

3 Cheng Y, Pang JC, Ng HK, et al. Pilocytic=20 astrocytomas do not show most of the genetic changes = commonly seen=20 in diffuse astrocytomas. Histopathology. 2000; = 37:=20 437-444.

4 Lang FF, Miller DC, Koslow M, Newcomb EW. = Pathways=20 leading to glioblastoma multiforme: a molecular analysis of = genetic=20 alterations in 65 astrocytic tumors. J Neurosurg. = 1994;=20 81: 427-436.

5 Ohgaki H, Schauble B, zur Hausen A, von = Ammon K,=20 Kleihues P. Genetic alterations associated with the = evolution and=20 progression of astrocytic brain tumors. Virchows = Arch. 1995;=20 427: 113-118.

6 Watanabe K, Tachibana O, Sata K, Yonekawa = Y,=20 Kleihues P, Ohgaki H. Overexpression of the EGF receptor and = p53 mutations are mutually exclusive in the evolution = of=20 primary and secondary glioblastomas. Brain Pathol. = 1996;=20 6: 217-223.

7 Sung T, Miller DC, Hayes RL, Alonso M, Yee = H,=20 Newcomb EW. Preferential inactivation of the p53 = tumor=20 suppressor pathway and lack of EGFR amplification = distinguish de=20 novo high grade pediatric astrocytomas from de novo adult=20 astrocytomas. Brain Pathol. 2000; 10: 249-259.

8 Jen J, Harper JW, Bigner SH, et al. = Deletion of p16=20 and p15 in brain tumors. Cancer Res. 1994; 54: = 6353-6358.

9 Biernat W, Tohma Y, Yonekawa Y, Kleihues P, = Ohgaki=20 H. Alterations of cell cycle regulatory genes in primary (de = novo)=20 and secondary glioblastomas. Acta Neuropathol (Berl). = 1997;=20 94: 303-309.

10 Reifenberger G, Liu L, Ichimura K, Schmidt = EE,=20 Collins VP. Amplification and overexpression of the MDM2 = gene in a=20 subset of human malignant gliomas without p53 = mutations.=20 Cancer Res. 1993; 53: 2736-2739.

11 Biernat W, Kleihues P, Yonekawa Y, Ohgaki = H.=20 Amplification and overexpression of MDM2 in primary (de = novo)=20 glioblastomas. J Neuropathol Exp Neurol. 1997; = 56:=20 180-185.

12 Fujisawa H, Reis RM, Nakamura M, et al. = Loss of=20 heterozygosity on chromosome 10 is more extensive in primary = (de=20 novo) than in secondary glioblastomas. Lab Invest. = 2000;=20 80: 65-72.

13 Fults D, Brockmeyer D, Tullous MW, Pedone = CA,=20 Cawthon RM. p53 mutation and loss of heterozygosity = on=20 chromosomes 17 and 10 during human astrocytoma progression.=20 Cancer Res. 1992; 52: 674-679.

14 Ishii N, Tada M, Hamou MF, et al. Cells = with TP53=20 mutations in low grade astrocytic tumors evolve clonally to=20 malignancy and are an unfavorable prognostic factor.=20 Oncogene. 1999; 18: 5870-5878.

16 Reifenberger J, Ring GU, Gies U, et al. = Analysis=20 of p53 mutation and epidermal growth factor receptor=20 amplification in recurrent gliomas with malignant = progression. J=20 Neuropathol Exp Neurol. 1996; 55: 822-831.

17 Watanabe K, Sato K, Biernat W, et al. = Incidence=20 and timing of p53 mutations during astrocytoma = progression in=20 patients with multiple biopsies. Clin Cancer Res. = 1997;=20 3: 523-530.

18 Louis DN, von Deimling A, Chung RY, et al. = Comparative study of p53 gene and protein alterations = in=20 human astrocytic tumors. J Neuropathol Exp Neurol. = 1993;=20 52: 31-38.

19 Ohgaki H, Watanabe K, Peraud A, et al. A = case=20 history of glioma progression. Acta Neuropathol. = 1999;=20 97: 525-532.

20 Haas-Kogan DA, Yount G, Haas M, et al.=20 p53-dependent G1 arrest and p53-independent = apoptosis=20 influence the radiobiologic response of glioblastoma. Int = J=20 Radiat Oncol Biol Phys. 1996; 36: 95-103.

21 Baxendine-Jones J, Campbell I, Ellison D.=20 p53 status has no prognostic significance in = glioblastomas=20 treated with radiotherapy. Clin Neuropathol. 1997; = 16:=20 332-336.

22 Newcomb EW, Cohen H, Lee SR, et al. = Survival of=20 patients with glioblastoma multiforme is not influenced by = altered=20 expression of p16, p53, EGFR, MDM2 or Bcl-2 genes. = Brain=20 Pathol. 1998; 8: 655-667.

23 Tada M, Matsumoto R, Iggo RD, et al. = Selective=20 sensitivity to radiation of cerebral glioblastoma harboring=20 p53 mutation. Cancer Res. 1998; 58: = 1793-1797.

24 Leenstra S, Oskam NT, Bijleveld EH, Bosch = DA,=20 Troost D, Hulsebos TJ. Genetic sub-types of human malignant=20 astrocytoma correlate with survival. Int J Cancer. = 1998;=20 79: 159-165.

25 Nieder C, Petersen S, Petersen C, Thames = HD. The=20 challenge of p53 as prognostic and predictive factor = in=20 gliomas. Cancer Treat Rev. 2000; 26: 67-73.

26 Schiebe M, Ohneseit P, Hoffmann W, = Meyermann R,=20 Rodemann HP, Bamberg M. Analysis of mdm2 and p53 gene = alterations in glioblastomas and its correlation with = clinical=20 factors. J Neurooncol. 2000; 49: 197-203.

27 Simmons ML, Lamborn KR, Takahashi M, et = al.=20 Analysis of complex relationships between age, p53, = epidermal=20 growth factor receptor, and survival in glioblastoma = patients.=20 Cancer Res. 2001; 61: 1122-1128.

28 Tada M, Iggo RD, Ishii N, et al. Clonality = and=20 stability of the p53 gene in human astrocytic tumor = cells:=20 quantitative analysis of p53 gene mutations by yeast=20 functional assay. Int J Cancer. 1996; 67: = 447-450.

29 Kraus JA, Glesmann N, Beck M, et al. = Molecular=20 analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes = in=20 long-term survivors of glioblastoma multiforme. J = Neurooncol.=20 2000; 48: 89-94.

30 Anker L, Ohgaki H, Ludeke BI, Herrmann HD, = Kleihues P, Westphal M. p53 protein accumulation and = gene=20 mutations in human glioma cell lines. Int J Cancer. = 1993;=20 55: 982-987.

31 Tada M, Iggo RD, Waridel F, et al. = Reappraisal of=20 p53 mutations in human malignant astrocytic neoplasms = by=20 p53 functional assay: comparison with conventional = structural=20 analyses. Mol Carcinog. 1997; 18: 171-176.

32 Flaman JM, Frebourg T, Moreau V, et al. A = simple=20 p53 functional assay for screening cell lines, blood, = and=20 tumors. Proc Natl Acad Sci. 1995; 92: = 3963-3967.

33 Gomez-Manzano C, Fueyo J, Kyritsis AP, et = al.=20 Adenovirus-mediated transfer of the p53 gene produces = rapid=20 and generalized death of human glioma cells via apoptosis. = Cancer=20 Res. 1996; 56: 694-699.

34 Lang FF, Yung WK, Raju U, Libunao F, Terry = NH,=20 Tofilon PJ. Enhancement of radiosensitivity of wild-type = p53=20 human glioma cells by adenovirus-mediated delivery of the = p53=20 gene. J Neurosurg. 1998; 89: 125-132.

35 Broaddus WC, Liu Y, Steele LL, et al. = Enhanced=20 radiosensitivity of malignant glioma cells after adenoviral=20 p53 transduction. J Neurosurg. 1999; = 91:=20 997-1004.

36 Jung JM, Bruner JM, Ruan S, et al. = Increased=20 levels of p21 WAF1/CIP1 in human brain tumors. = Oncogene.=20 1995; 11: 2021-2028.

38 Ruan S, Okcu MF, Ren JP, et al. = Overexpressed=20 WAF1/Cip1 renders glioblastoma cells resistant to = chemotherapy=20 agents 1, 3-bis(2-chloroethyl)-1-nitrosourea and cisplatin.=20 Cancer Res. 1998; 58: 1538-1543.

39 Nutt CL, Noble M, Chambers AF, Cairncross = JG.=20 Differential expression of drug resistance genes and=20 chemosensitivity in glial cell lineages correlate with = differential=20 response of oligodendrogliomas and astrocytomas to = chemotherapy.=20 Cancer Res. 2000; 60: 4812-4818.

40 Pomerantz J, Schreiber-Agus N, Liegeois = NJ, et al.=20 The Ink4a tumor suppressor gene product, p19 Arf, interacts = with=20 MDM2 and neutralizes MDM2's inhibition of p53. = Cell.=20 1998; 92: 713-723.

41 Honda R, Yasuda H. Association of p19 ARF = with=20 Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor = suppressor=20 p53. EMBO J. 1999; 18: 22-27.

42 Matsumoto R, Tada M, Nozaki M, Zhang C, = Sawamura=20 Y, Abe H. Short alternative splice transcripts of the mdm2 = oncogene=20 correlate to malignancy in human astrocytic neoplasms. = Cancer=20 Res. 1998; 58: 609-613.

43 Kraus A, Neff F, Behn M, Schuermann M, = Muenkel K,=20 Schlegel J. Expression of alternatively spliced mdm2 = transcripts=20 correlates with stabilized wild-type p53 protein in = human=20 glioblastoma cells. Int J Cancer. 1999; 80: = 930-934.

44 Perry ME, Mendrysa SM, Saucedo LJ, Tannous = P,=20 Holubar M. p76 MDM2 inhibits the ability of p90 MDM2 to = destabilize=20 p53. J Biol Chem. 2000; 275: 5733-5738.

45 Buschmann T, Fuchs SY, Lee CG, Pan ZQ, = Ronai Z.=20 SUMO-1 modification of Mdm2 prevents its self-ubiquitination = and=20 increases Mdm2 ability to ubiquitinate p53. = Cell.=20 2000; 101: 753-762.

46 Oda K, Arakawa H, Tanaka T, et al. = P53AIP1, a=20 potential mediator of p53-dependent apoptosis, and = its=20 regulation by ser-46-phosphorylated p53. Cell. = 2000;=20 102: 849-862.

47 Oda E, Ohki R, Murasawa H, et al. Noxa, a = BH3-only=20 member of the bcl-2 family and candidate mediator of=20 p53-induced apoptosis. Science. 2000; = 288:=20 1053-1058.

49 Di Como CJ, Prives C. Human tumor-derived=20 p53 proteins exhibit binding site selectivity and = temperature=20 sensitivity for transactivation in a yeast-based assay.=20 Oncogene. 1998; 16: 2527-2539.

3D""=20

------=_NextPart_000_0059_01C86A81.34F07B40 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/blank.html UNTITLED_PAGE= ------=_NextPart_000_0059_01C86A81.34F07B40--