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{=0A= document.writeln('3D"Click');=0A= }=0A= =0A= function get_text_link(url, linktext)=0A= {=0A= document.writeln('' + = linktext + '');=0A= }=0A= =0A= function get_htmlftext_link(a, b) {=0A= document.writeln("" + = b + ", ");=0A= }=0A= =0A= ------=_NextPart_000_010E_01C8EB51.9A52DFE0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/personalisation.js /*=0A= * Project : Interscience Redesign=0A= * File : personalisation.js=0A= * Creation Date : 25th March 2003=0A= * Author : Jonathan Sugar=0A= *=0A= * Various functions to deliver personalisation functionality.=0A= */=0A= =0A= // Pre-declare userName so it's available when we need to test if the = page=0A= // assembler ran OK=0A= var userName =3D null;=0A= var shcrtCookie =3D null;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Factory Methods=0A= =0A= // Simple wraper object to encapsulate the data for a co-branding item.=0A= function coBrandingItem(image, imageAltText, href)=0A= {=0A= //alert("Making new coBrandingItem:\nImage: " + image + = "\nimageAltText" + imageAltText + "\nhref: " + href);=0A= this.image =3D image;=0A= this.imageAltText =3D imageAltText;=0A= this.href =3D href;=0A= }=0A= =0A= /*=0A= * Insert the 'Customer co-branding' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert customer co branding. Loop through 'customerCoBranding' array=0A= * inserting XHTML where needed.=0A= *=0A= * NOTE: the array contains ONLY the resource location (the location of a = gif=0A= * on the file system), the required XHTML is then added where needed. = This way=0A= * we maintain the seperation between presentation and content.=0A= */=0A= function insertCustomerCoBranding(maxBranding)=0A= {=0A= if( customerCoBranding[0].image !=3D "none")=0A= {=0A= document.writeln('
');=0A= document.writeln('
3D"provided
');=0A= document.writeln('
    ');=0A= =0A= var i;=0A= //Change start for bug#2288=0A= if(typeof(maxBranding) =3D=3D "undefined" | maxBranding =3D=3D "" | = maxBranding =3D=3D 0){=0A= maxBranding =3D 3; // DEFAULT Value for No of Cobranding dispaly=0A= }=0A= var size =3D customerCoBranding.length;=0A= if(maxBranding !=3D -1 & size-1 > maxBranding){=0A= size =3D maxBranding;=0A= }=0A= //Change End for bug#2288=0A= =0A= // Add the co-branding images o the page.=0A= //for(i=3D0; i < customerCoBranding.length; i++ )=0A= for(i=3D0; i < size; i++ )=0A= {=0A= // ignore the terminating array element.=0A= if(customerCoBranding[i].image =3D=3D "none")=0A= {=0A= continue;=0A= }=0A= =0A= this.image =3D customerCoBranding[i].image;=0A= this.imageAltText =3D customerCoBranding[i].imageAltText;=0A= this.href =3D customerCoBranding[i].href;=0A= =0A= if (image =3D=3D "")=0A= {=0A= if(href =3D=3D "")=0A= {=0A= document.writeln('
  • ' + imageAltText + '
    • ');=0A= }=0A= else=0A= {=0A= document.writeln('
  • ' + imageAltText + = '
    • ');=0A= }=0A= }=0A= else=0A= {=0A= if(href =3D=3D "")=0A= {=0A= document.writeln('
  • 3D"'
    • ');=0A= }=0A= else=0A= {=0A= document.writeln('
  • 3D"'
    • ');=0A= }=0A= }=0A= }=0A= =0A= // If there are more co-branding images add in a link to them.=0A= // Changes made for Bug#2288=0A= //if(moreCustomerCoBranding =3D=3D "true")=0A= if(maxBranding !=3D -1 & customerCoBranding.length-1 > maxBranding)=0A= {=0A= document.writeln('
  • More Providers
    • ');=0A= }=0A= =0A= document.writeln('
');=0A= document.writeln('
');=0A= document.writeln('
3D""
');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the 'My Area' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= *=0A= * My profile link absolute as this file isnt only run from w3 anymore.=0A= */=0A= function insertMyArea(userdata)=0A= {=0A= // just in case the page assembler isn't running.=0A= =0A= =0A= if (userName !=3D null)=0A= {=0A= document.writeln("
    ");=0A= if(typeof(environment)!=3D'undefined' && environment!=3D'PRODUCTION')=0A= {=0A= if(userName !=3D "")=0A= {=0A= //write out the user specific data for the menu=0A= if (userdata !=3D null){=0A= if (userName.length > 33){=0A= var writedata =3D "
  • " + = userName.substring(0,33) + "..., access your
    • ";=0A= } else {=0A= var writedata =3D "
  • " + userName + = ", access your
    • ";=0A= }=0A= =0A= for (var x=3D0; xMy Profile"); =0A= } =0A= document.writeln(getLoginOutLink());=0A= //CR 3652 getAthenStatus() as added=0A= document.writeln(getAthenStatus());=0A= document.writeln("
");=0A= }=0A= if (menuloadedflag){=0A= wisMenu();=0A= }=0A= }=0A= =0A= /*=0A= * Insert the Customer Admin 'Login/Logout' link=0A= * -----------------------------=0A= *=0A= * Author: Bobby Jack, December 2004.=0A= *=0A= */=0A= function insertAdminLink(page)=0A= {=0A= val =3D getCookie("AID");=0A= =0A= if (val && val !=3D "-1")=0A= {=0A= document.writeln('
  • Logout');=0A= }=0A= else=0A= {=0A= document.writeln('
  • Login
    • ');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the username section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert the username.=0A= */=0A= function insertUserName()=0A= {=0A= document.write(userName);=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the login/logout cgi=0A= * ---------------------------------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= * Had to change the links absolute as this file isnt only run from w3 = anymore.=0A= */=0A= function getLoginOutLink()=0A= {=0A= if(userName !=3D "")=0A= {=0A= return "
  • Log Out
    • ";=0A= }else=0A= {=0A= return "
  • Log = In
    • ";=0A= }=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the shopping cart content page=0A= * ---------------------------------------------------=0A= *=0A= * Author: Zhiming & Warrell June 2007=0A= */=0A= function getShCrtLink(logged)=0A= {=0A= if(logged =3D=3D true )=0A= return "
    • ";=0A= else=0A= return "
    • ";=0A= }=0A= =0A= function toggleShCrtLink()=0A= {=0A= shcrtCookie =3D readCookie("SHCRT");=0A= if(shcrtCookie !=3D null)=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "block";=0A= }=0A= }=0A= else=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "none";=0A= }=0A= }=0A= }=0A= =0A= =0A= =0A= function readCookie(name)=0A= {=0A= var nameEQ =3D name + "=3D";=0A= var ca =3D document.cookie.split(';');=0A= for(var i=3D0; iYou are logged in = to Athens';=0A= }else=0A= {=0A= return "
  • Athens Log In
    • ";=0A= }=0A= =0A= }=0A= =0A= ------=_NextPart_000_010E_01C8EB51.9A52DFE0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/site.js /************************************************************************= ***************************=0A= FILE: site.js=0A= AUTHOR: Jonathan Sugar, Chris Neatby-Smith and Digital Pulp. July = 2003.=0A= =0A= DESCRIPTION: Javascript relating to site wide functionality across =0A= InterScience.=0A= =0A= INCLUDES FUNCTIONS=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Search Functions=0A= ----------------=0A= =0A= selectAndSubmit() - for deciding where to submit a query based on the = state of the form.=0A= processallContentSearch() - for validating form input for an all = content search.=0A= processTitleSearch() - for validating form input for a Title search.=0A= checkCitationSearch() - for validating the citation search form.=0A= selectAll() - check all the checkboxes in a form.=0A= do_popup() - stasa Acronym Finder window popup function.=0A= =0A= =0A= Other Functions=0A= ---------------=0A= =0A= fixInlineLists() - fix netscape 4.x bug where
  • tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract  |  References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if (arguments.length >=3D 4 && arguments[3] =3D=3D 'cluster')=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln('3D"blank"');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln('3D"blank"'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x" + = liels[j].innerHTML + "
  • You do not have = anything saved in this menu.
    • ";=0A= else=0A= tmpinnerhtml +=3D "
  • " = + liels[j].innerHTML + "
    • "; =0A= } =0A= } else {=0A= //setup var to see if more is required=0A= var more =3D (subnodeslength < lilength) ? true : = false; =0A= var flag =3D true;=0A= for (var j=3D0; j" + liels[j].innerHTML + = "";=0A= } else if (j > lilength-3){=0A= if (j =3D=3D lilength-2){=0A= var url =3D liels[j].innerHTML.split('"')[1];=0A= tmpinnerhtml +=3D "
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    • ";=0A= } else {=0A= tmpinnerhtml +=3D "
  • " + liels[j].innerHTML + = "
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    3D"Jump

    Glia
    ISSN: 1098-1136 (Online)
    ISSN: 0894-1491 (Print)

    Volume 43, Issue 1, 2003.
    Pages: 4-5
    • Top of page
    • Abstract
    Abstract=20 Only

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    3D"About

    Online ISSN: 1098-1136    Print ISSN: = 0894-1491
    Glia
    Volume 43, Issue 1, 2003. Pages: 4-5
    (Special Issue: Glia as Stem Cells in Development and = Adulthood. Issue Edited by Magdalena Götz, Dennis = Steindler.)

    Copyright © 2003 = Wiley-Liss, Inc.

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    Glia

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    Volume 43, Issue 1, Pages 4-5

    Published Online: 16 May 2003

    Copyright =A9 2003 Wiley-Liss, Inc., A Wiley Company

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    3D""=20
     Original Article
    What is a glial = cell?
    Ben A. Barres = *
    Stanford University School of Medicine, Department of=20 Neurobiology, Fairchild D235, Stanford, = California
    email: Ben A. Barres (barres@stanford.edu)

    *Correspondence to Ben A. = Barres,=20 Stanford University School of Medicine, Department of = Neurobiology,=20 Fairchild D235, 299 Campus Drive, Stanford, CA 94305-5125

    Abstract
    3DAbstract=20
    No abstract.

    Received: 28 March 2003; Accepted: 28 March 2003

    Digital Object Identifier=20 = (DOI)

    10.1002/glia.10252 = ; About=20 DOI

    Article=20 Text

    The last few years has seen a revolution in our understanding = of glial=20 cells. We now know that astrocytes, in addition to mopping up = transmitters=20 and maintaining extracellular ion levels, actively control = synaptogenesis,=20 synapse number, synapse function, and synaptic plasticity. Even=20 oligodendrocytes and Schwann cells, are active participants in = nervous=20 system function. In addition to providing insulation and trophic = support=20 to neurons, they sculpt the structure and electrical properties of = axons=20 by controlling their diameter, the spacing and clustering of ion = channels=20 at the node and paranode. Schwann cells also control the = regeneration of=20 axons and the function of synapses at the neuromuscular junction. = Neurons=20 and glia divide metabolic labor in a way that, though still poorly = understood, no doubt underlies an interaction vital to proper = nervous=20 system function and perhaps much of the brain's response to = ischemia. In=20 short, virtually every aspect of brain development and function = involves a=20 neuron-glial partnership. It is no longer tenable to consider glia = as=20 passive support cells.

    There are an endless number of important questions about = neuron-glial=20 interactions. Exactly how is metabolic labor divided between = neurons and=20 glia and what is the point of this? What is the identity of the = signals=20 flowing between neurons and glia and what is their purpose? Might=20 astrocytes be the primary synthesizers of neurotransmitters or = their=20 immediate biochemical precursors, rather than neurons? Do = astrocytes play=20 a role in inducing and maintaining the blood-brain barrier, or is = another=20 cell type responsible? Do astrocytes actually help to signal = neuronal=20 survival in vivo? And what is the point of reactive astrocytes; = are they=20 good, bad, or both? I know of little convincing data that = addresses most=20 of these questions, but newly developed methods for genomics, = proteomics,=20 RNA interference, neural cell purification and culture, all offer = a way=20 forward. These new methods provide powerful new ways to better=20 characterize glia and their interactions with neurons, and to = perform=20 question-oriented, hypothesis-driven research about glial = function.

    An important, closely related set of questions is raised by = recent=20 studies on neural stem cells and gliogenesis reviewed in this = special=20 issue. These papers review the amazing findings of the last few = years that=20 some glia=20 can actually behave as multipotent neural stem cells that can = generate=20 neurons, both in vitro and in vivo. Radial glia and subventricular = zone=20 astrocytes have all been shown to do this in developing and adult = brains,=20 respectively. A subset of ependymal cells also appears to have the = capacity to generate new neurons, although they now appear to lack = the=20 self-renewing ability of a true stem cell. In addition, in the = adult=20 chick, Muller glial cells in the retina and supporting glial cells = in the=20 inner ear can be induced after injury or growth factor stimulation = to=20 generate new neurons. Even oligodendrocyte precursor cells in = culture can=20 be induced with certain growth factors to become multipotent = neural stem=20 cells. It is quite important to note, however, that most glial = cells in=20 the CNS are not neural stem cells, but rather a distinct = subset.

    The new findings that glia can be neural stem cells raise a = difficult=20 question. When should a cell be called a glial cell? Several = papers in=20 this issue will review the astounding recent discovery that in = developing=20 rodent brains, radial glia give rise to the majority of pyramidal = neurons.=20 So, are these radial glia actually glial cells after all? This = question is=20 especially thorny given that radial glia also subserve a = traditional glial=20 function of guiding the migration of developing neurons. = Nonetheless I=20 would argue that they should no longer be called glial cells = because we=20 now know that their most important function is to be neural stem = cells.=20 That radial glia also guide migration does not sway me, because I = believe=20 that all cell classes in the brain, including neurons and glia,=20 simultaneously perform both passive support roles and more active = roles.=20 For instance, considerable evidence now indicates that neurons = provide=20 trophic support for glia. In fact, the evidence that neurons = support glia=20 in the brain in vivo is far stronger than the evidence that glia = support=20 neurons. Thus, I see no reason why we shouldn't return to the = nomenclature=20 of the early neurohistologists and refer to radial glial cells as=20 neuroepithelial cells, just as we do in the developing retina.

    Similarly, should the subventricular zone astrocytes that = generate=20 neurons be referred to as astrocytes? I once again have considerable reservation. Though = these cells=20 may express a few proteins such as GFAP or S100, this alone is clearly insufficient = to make them=20 deserving of the name astrocyte. Though strongly expressed by = white matter=20 astrocytes, GFAP is hardly expressed by most protoplasmic = astrocytes, and=20 is strongly expressed by a number of non-neural cell types outside = the=20 nervous system. Similarly, S100 is expressed by cell types besides = astrocytes=20 such as oligodendrocyte precursor cells. Until there is convincing = evidence that they share important astrocyte functions, I propose = that we=20 call them arturocytes in honor of the person who discovered them = and so=20 beautifully demonstrated their function as neural stem cells. It = is far=20 past time to stop calling every neural cell in the brain that is = not a=20 neuron, a glial cell.

    Finally, the exciting advances reviewed in this special issue, = raise=20 many important questions. First of all, how are white matter = (fibrous) and=20 grey matter (protoplasmic) astrocytes normally generated? Both = radial glia=20 and SVZ stem cells have been shown to generate primarily = protoplasmic=20 astrocytes, so it is still very mystical how the bulk of fibrous=20 astrocytes arise, and how their functions compare to those of = protoplasmic=20 astrocytes. Radial glia are intrinsically different in their = neurogenic=20 potential from region to region; how are these intrinsic = differences=20 specified? Why do radial glia and Muller cells maintain their = ability to=20 behave as stem cells in some organisms but not others? Do = aberrantly=20 persisting glial=20 stem cells in some cases lead to gliomas, and is their failure to = persist=20 in mammals relevant to understanding the evolutionary loss of = regenerative=20 ability in our CNS? Most importantly, how can we harness the stem = cell=20 abilities of some glia to generate new neurons to rebuild damaged = brains?=20 One thing is certain; there has never been a better time for young = neuroscientists to enter this field.
    3D""=20
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