From: Subject: Oncomirs [mdash] microRNAs with a role in cancer : Article : Nature Reviews Cancer Date: Fri, 9 May 2008 12:31:42 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C8B1D0.A3459760" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nrc/journal/v6/n4/full/nrc1840.html Oncomirs [mdash] = microRNAs with a role in cancer : Article : Nature Reviews = Cancer

Welcome back: Giovanni Camporeale
Logout of=20 nature.com

3D"Nature=20
= = Advanced search=20
Journal = home > Archive >=20 Review= > Full = Text

Review

Nature Reviews Cancer = 6, 259-269 = (April 2006) | = doi:10.1038/nrc1840

Oncomirs =97 microRNAs with a role in cancer

Aurora Esquela-Kerscher1=20 & Frank J. Slack1 =20 Abo= ut the=20 authors

To= p of page

Abstract

MicroRNAs (miRNAs) are an abundant class of small=20 non-protein-coding RNAs that function as negative gene regulators. They = regulate=20 diverse biological processes, and bioinformatic data indicates that each = miRNA=20 can control hundreds of gene targets, underscoring the potential = influence of=20 miRNAs on almost every genetic pathway. Recent evidence has shown that = miRNA=20 mutations or mis-expression correlate with various human cancers and = indicates=20 that miRNAs can function as tumour suppressors and oncogenes. miRNAs = have been=20 shown to repress the expression of important cancer-related genes and = might=20 prove useful in the diagnosis and treatment of cancer.

Cancer is caused by uncontrolled proliferation and the=20 inappropriate survival of damaged cells, which results in tumour = formation.=20 Cells have developed several safeguards to ensure that cell division,=20 differentiation and death occur correctly and in a coordinated fashion, = both=20 during development and in the adult body. Many regulatory factors switch = on or=20 off genes that direct cellular proliferation and differentiation. Damage = to=20 these genes, which are referred to as tumour-suppressor genes and = oncogenes, is=20 selected for in cancer. Most tumour-suppressor genes and oncogenes are = first=20 transcribed from DNA into RNA, and are then translated into protein to = exert=20 their effects. Recent evidence indicates that small non-protein-coding = RNA=20 molecules, called microRNAs (miRNAs), might also function as tumour = suppressors=20 and oncogenes.

We are just beginning to understand how this novel class = of gene=20 regulators is involved in cancer-related pro-cesses in humans. Out of = hundreds=20 of miRNAs that have recently been identified, only a small number from = worm, fly=20 and human genomes have been characterized. They have been shown to = control cell=20 growth, differentiation and apoptosis; consequently, impaired miRNA = expression=20 has been implicated in tumorigenesis. Continued research into miRNA = function=20 might lead to an advanced understanding of the mechanisms that lead to=20 tumorigenesis. In this Review, we discuss the emerging field of = 'oncomirs' =97=20 miRNAs that are associated with cancer =97 and how these miRNAs could be = used in=20 the diagnosis and treatment of cancer.

miRNAs are a=20 large family of gene regulators

miRNAs are non-coding, single-stranded RNAs of 22=20 nucleotides and constitute a novel class of gene regulators that are = found in=20 both plants and animals1.=20 They negatively regulate their targets in one of two ways depending on = the=20 degree of complementarity between the miRNA and the target (Fig= . 1).=20 First, miRNAs that bind with perfect or nearly perfect complementarity = to=20 protein-coding mRNA sequences induce the RNA-mediated interference = (RNAi)=20 pathway (see Ref. 2 for a=20 review on RNAi). Briefly, mRNA transcripts are cleaved by ribonucleases = in the=20 miRNA-associated, multiprotein RNA-induced-silencing complex (miRISC), = which=20 results in the degradation of target mRNAs. This mechanism of = miRNA-mediated=20 gene silencing is commonly found in plants3, = 4, = 5,=20 but miRNA-directed mRNA cleavage has also been shown to occur in = mammals6.=20 However, most animal miRNAs are thought to use a second mechanism of = gene=20 regulation that does not involve the cleavage of their mRNA targets. = These=20 miRNAs exert their regulatory effects by binding to imperfect = complementary=20 sites within the 3' untranslated regions (UTRs) of their mRNA targets, = and they=20 repress target-gene expression post-transcriptionally, apparently at the = level=20 of translation, through a RISC complex that is similar to, or possibly = identical=20 with, the one that is used for the RNAi pathway7, = 8, = 9, = 10= ,=20 11= ,=20 12= ,=20 13= ,=20 14= ,=20 15= ,=20 16= ,=20 17= ,=20 18= .=20 Consistent with translational control, miRNAs that use this mechanism = reduce the=20 protein levels of their target genes, but the mRNA levels of these genes = are=20 barely affected. However, recent findings indicate that miRNAs that = share only=20 partial complementarity with their targets can also induce mRNA = degradation, but=20 it is unclear if translational inhibition precedes destabilization of = the gene=20 targets in these cases19= ,=20 20= .

= Figure=20 1 | The biogenesis of microRNAs.
=

MicroRNA (miRNA) genes are generally transcribed by RNA Polymerase II = (Pol=20 II) in the nucleus to form large pri-miRNA transcripts, which are capped = (7MGpppG) and polyadenylated (AAAAA). These pri-miRNA = transcripts are=20 processed by the RNase III enzyme Drosha and its co-factor, Pasha, to = release=20 the 70-nucleotide=20 pre-miRNA precursor product. (Note that the human let-7a-1=20 miRNA is shown here as an example of a pre-miRNA hairpin sequence. The = mature=20 miRNA sequence is shown in red.) RAN=96GTP and exportin 5 transport the = pre-miRNA=20 into the cytoplasm. Subsequently, another RNase III enzyme, Dicer, = processes the=20 pre-miRNA to generate a transient 22-nucleotide=20 miRNA:miRNA* duplex. This duplex is then loaded into the=20 miRNA-associated multiprotein RNA-induced silencing complex (miRISC) = (light=20 blue), which includes the Argonaute proteins, and the mature = single-stranded=20 miRNA (red) is preferentially retained in this complex. The mature miRNA = then=20 binds to complementary sites in the mRNA target to negatively regulate = gene=20 expression in one of two ways that depend on the degree of = complementarity=20 between the miRNA and its target. miRNAs that bind to mRNA targets with=20 imperfect complementarity block target gene expression at the level of = protein=20 translation (lower left). However, recent evidence indicates that miRNAs = might=20 also affect mRNA stability (not shown). Complementary sites for miRNAs = using=20 this mechanism are generally found in the 3' untranslated regions (3' = UTRs) of=20 the target mRNA genes. miRNAs that bind to their mRNA targets with = perfect (or=20 nearly perfect) complementarity induce target-mRNA cleavage (lower = right).=20 miRNAs using this mechanism bind to miRNA complementary sites that are = generally=20 found in the coding sequence or open reading frame (ORF) of the mRNA = target.


The biogenesis of miRNAs has only recently been = elucidated1=20 (Fig= .=20 1). miRNAs, which generally seem to be transcribed by RNA polymerase = II, are=20 initially made as large RNA precursors that are called pri-miRNAs. The=20 pri-miRNAs are processed in the nucleus by the RNase III enzyme, Drosha, and the=20 double-stranded-RNA-binding protein, Pasha (also known as = DGCR8), into=20 70-nucleotide=20 pre-miRNAs, which fold into imperfect stem-loop structures21= ,=20 22= ,=20 23= ,=20 24= ,=20 25= ,=20 26= ,=20 27= ,=20 28= .=20 The pre-miRNAs are then exported into the cytoplasm by the RAN = GTP-dependent=20 transporter exportin = 5 (Refs=20 29= ,=20 30= ,=20 31= )=20 and undergo an additional processing step in which a double-stranded RNA = of 22=20 nucleotides in length, referred to as the miRNA:miRNA* = duplex, is=20 excised from the pre-miRNA hairpin by another RNAse III enzyme, Dicer19= ,=20 32= ,=20 33= ,=20 34= .=20 Subsequently, the miRNA:miRNA* duplex is incorporated into = the miRISC=20 complex. The mature miRNA strand is preferentially retained in the = functional=20 miRISC complex and negatively regulates its target genes (see = above).

Many researchers failed to appreciate the importance of = miRNAs=20 when they were initially described more than a decade ago. This is = because the=20 first miRNA gene that was identified, lin-4, was = thought to=20 be unique to the roundworm Caenorhabditis elegans = and=20 control the timing and progression of the nematode life cycle8, = 12= ,=20 35= .=20 However, the identification of hundreds of miRNAs within worm, fly and = mammalian=20 genomes by traditional cloning techniques and bioinformatics12= ,=20 17= ,=20 21= ,=20 36= ,=20 37= ,=20 38= ,=20 39= ,=20 40= ,=20 41= ,=20 42= ,=20 43= ,=20 44= ,=20 45= ,=20 46= ,=20 47= ,=20 48= ,=20 49= ,=20 50= =20 has now captured the attention of scientists specializing in various = different=20 fields. There are estimated to be at least 300 miRNAs (and there might = be as=20 many as 1000) in the human genome, comprising 1=964%=20 of all expressed human genes, which makes miRNAs one of the largest = classes of=20 gene regulator46= ,=20 51= ,=20 52= .=20 Most human miRNAs are found within introns of either protein-coding or = noncoding=20 mRNA transcripts53= .=20 The remaining miRNAs are either located far from other transcripts in = the=20 genome, within the exons of noncoding mRNA genes or within the 3' UTRs = of mRNA=20 genes, or they are clustered with other miRNA genes, including a cluster = on=20 chromosome 19 that is comprised of 54 novel miRNAs1, = 27= ,=20 52= ,=20 53= ,=20 54= .=20 miRNAs can be grouped into families on the basis of sequence homology, = which is=20 found primarily at the 5' end of the mature miRNAs, but whether members = of the=20 same miRNA family control similar biological events remains to be seen. = Many=20 miRNAs are evolutionarily conserved from worms to humans, which implies = that=20 these miRNAs direct essential processes both during development and in = the adult=20 body.

miRNAs = regulate multiple=20 gene targets

The current challenge is to accurately identify targets = that are=20 regulated by miRNAs. Because miRNAs usually bind to their targets with=20 incomplete complementarity, which allows short stretches of mismatched=20 base-pairs and G=96U base pairing, the identification of gene targets = with a=20 simple BLAST search is impossible. However, current bioinformatic = approaches=20 have taken advantage of the fact that miRNAs within families have = highest=20 homology at the 5' end of the mature miRNA. Several studies have = indicated that=20 the 5' end of the miRNA is crucial for the stability and proper loading = of the=20 miRNA into the miRISC complex55= ,=20 56= ,=20 and this end is also important for biological function57= ,=20 58= ,=20 59= .=20 Therefore, most bioinformatic algorithms use a 'miRNA seed' that = encompasses the=20 first 2=968 bases of the mature miRNA sequence to search for = complementarity to=20 sequences in the 3' UTR of all expressed genes. These studies have = revealed that=20 a single miRNA might bind to as many as 200 gene targets and that these = targets=20 can be diverse in their function; they include transcription factors, = secreted=20 factors, receptors and transporters20= ,=20 47= ,=20 60= ,=20 61= ,=20 62= ,=20 63= ,=20 64= ,=20 65= ,=20 66= ,=20 67= ,=20 68= .=20 So, miRNAs potentially control the expression of about one-third of = human=20 mRNAs.

However, many targets are missed using the 'miRNA seed' = approach=20 as there is evidence that other variables besides the first 2=968 = nucleotides of=20 the miRNA sequence dictate miRNA regulation. For example, the complete = mature=20 miRNA sequence of let-7 has been evolutionarily conserved from worms = to=20 humans37= ,=20 demonstrating the functional relevance of the 3' end. Furthermore, = mutagenesis=20 studies in our laboratory have shown that base pairing at both the 5' = and 3'=20 ends of let-7 is required for downregulation of a = target=20 gene69= .=20 Therefore, the number of known miRNA targets could increase and the = challenge=20 will be to determine which predicted targets are biologically relevant. = Sites=20 that are complementary to several miRNAs have also been identified = within the 3'=20 UTR of a single gene target, indicating that complex patterns of = combinatorial=20 regulation by miRNAs exist12= ,=20 16= ,=20 61= ,=20 70= .=20 Because miRNAs potentially have a broad influence over several diverse = genetic=20 pathways, the deletion or misexpression of these small RNAs is likely to = be=20 pleotropic and contribute to disease, including cancer.

The=20 miRNA-associated genes and human cancer

Components of the miRNA-machinery have been implicated = in=20 tumorigenesis. Expression of Dicer has been shown to be downregulated in = lung = cancer71= .=20 Karube et al. examined RNA expression levels of = DICER and DROSHA in 67 = non-small-cell lung=20 cancer samples71= .=20 They found that reduced expression of DICER = correlates with=20 shortened post-operative survival, which indicates that Dicer might be = able to=20 prevent the transformation of lung tissue. As Dicer has been implicated = in=20 heterochromatin maintenance and centromeric silencing, reduced protein = levels=20 might directly result in genomic instability and lead to tumour = formation71= ,=20 72= ,=20 73= .=20 However, Kanellopoulou et al. recently showed = that mouse=20 embryonic stem (ES) cells that lack Dicer showed = no=20 aberrations in chromosome number or structure despite observed = heterochromatin=20 deficits, and the injection of these Dicer-deficient ES=20 cells into nude mice failed to generate tumours72= .=20 Therefore, the potential role of Dicer in tumour formation might be = indirect and=20 result from the reduction of miRNAs in the lung that posses = tumour-suppressor=20 characteristics. Dicer gene-disruption studies in = mice have=20 shown that this gene is important during mammalian development and = directs=20 proper stem-cell differentiation, T-cell specification and limb = morphogenesis,=20 presumably reflecting the role of mature miRNAs in these = processes72= ,=20 74= ,=20 75= ,=20 76= ,=20 77= .=20 Therefore, the association of Dicer with lung = cancer=20 indicates a further role for this gene, and perhaps miRNAs, during lung=20 differentiation.

The Argonaute proteins, which are crucial components of = the RISC=20 complex that direct both short interfering (siRNA)- and miRNA-mediated = gene=20 regulation, have also been associated with various cancers. Three human=20 Argonaute genes =97 AGO3 (also known as eukaryotic = translation-initiation factor=20 2 subunit 3 (EIF2C3)), AGO1 (also known as EIF2C1) = and AGO4 (also known as EIF2C4), = which are=20 clustered on chromosome 1 (1p34=9635) =97 are frequently deleted in Wilms tumour = of the=20 kidney and have also been associated with neuro-ectodermal = tumours7, = 78= .=20 AGO1 is highly expressed in the developing lung = and kidney=20 and is notably increased in renal = tumours that=20 lack the Wilms-tumour suppressor gene, WT1=20 (Ref. 7). This=20 indicates a role for AGO1 in the differentiation = of these=20 tissues during embryogenesis. An additional Argonaute gene, HIWI, which is the human orthologue of the Drosophila melanogaster Argonaute gene piwi, maps to the genomic region 12q24.33, which is = a locus=20 that is associated with testicular = germ-cell=20 cancers79= .=20 This testis-specific gene was found to be upregulated in 12 out of 19 = testicular=20 seminomas (tumours that are derived from embryonic germ cells). These = studies=20 indicate that HIWI might have oncogenic activity = and might=20 normally function to control the proliferation and maintenance of germ = cells.=20 Further insight into the accessory proteins that comprise the machinery=20 mediating miRNA processing and miRNA-directed gene repression will be = important=20 when designing therapeutic drugs that use miRNAs to treat disorders such = as=20 cancer.

miRNAs, = growth,=20 differentiation and disease

The biological roles of only a small fraction of = identified miRNAs=20 have been elucidated to date. These miRNAs regulate cancer-related = processes=20 such as cell growth and tissue differentiation, and therefore might = themselves=20 function as oncomirs. For example, the miRNAs that are encoded by lin-4 and let-7 control the = timing of cell=20 differentiation and proliferation in C. elegans. = Mutations=20 in these C. elegans miRNA genes lead to = abnormalities in=20 cell-cycle exit and terminal differentiation, which are characteristics = that are=20 found in cancer cells. Interestingly, the mammalian homologues of lin-4 and let-7 have been shown = to control=20 cell proliferation in human cell lines80= ,=20 81= =20 and are also associated with various cancers81= ,=20 82= ,=20 83= ,=20 84= ,=20 85= =20 (discussed below).

The D. melanogaster miRNA that is = encoded by=20 bantam induces tissue growth by both stimulating = cell=20 proliferation and inhibiting apoptosis17= ,=20 86= ,=20 which are features that are shared with bona fide = oncogenes. However, there are no close homologues of bantam=20 in humans. Another D. melanogaster miRNA, miR= -14,=20 is a strong suppressor of apoptosis, which is also an important = oncogenic=20 characteristic49= .=20 In addition, miR-14 also seems to have unrelated functions in the D. melanogaster stress-response pathway and in = regulating fat=20 metabolism49= .=20 Other characterized miRNAs have essential functions during development = and=20 direct the proper differentiation of cells into various tissues. = Examples=20 include miR= -273=20 and the miRNA that is encoded by lys-6, which are involved in patterning the C.=20 elegans nervous system43= ,=20 50= ;=20 miR-430 in Danio rerio brain development87= ;=20 miR-= 181=20 in the differentiation of mammalian haematopoietic cells towards the = B-cell=20 lineage88= ;=20 miR-= 375=20 in mammalian pancreatic islet-cell development and the regulation of = insulin=20 secretion89= ;=20 miR-= 143=20 during mammalian adipocyte differentiation90= ;=20 miR-196 in mammalian limb patterning91= ;=20 and the miR-1 genes during mammalian heart development92= .=20 Further characterization of novel miRNAs might reveal other gene = regulators that=20 coordinate proper organ formation, embryonic patterning and body growth, = and=20 might also provide insight into the mechanisms of human diseases such as = cancer.

miRNAs that = are=20 implicated in cancer

miRNA expression correlates with various cancers, and = these genes=20 are thought to function as both tumour suppressors and oncogenes (Fig= . 2;=20 Tab= le=20 1). A recent study showed that about 50% of annotated human miRNAs = are=20 located in areas of the genome, known as fragile=20 sites, that are associated with cancer. This indicates that miRNAs = might=20 have a crucial function in cancer progression83= .=20 For example, mir-125b-1, the homologue of C. = elegans=20 lin-4, is located in a fragile site on chromosome 11q24, which is = deleted=20 in a subset of patients with breast, = lung, ovarian = and cervical=20 cancer83= .=20 A report by Sonoki et al. also linked this gene = with leukaemia,= and=20 described a patient with precursor-B-cell acute lympho-blastic leukaemia = who=20 carried an insertion of pre-miRNA into the immunoglobulin heavy-chain=20 locus85= .=20 Although the investigators could not determine how mir-125b-1 expression85= =20 was modulated in the tumour cells, this study supports a role for this = gene as=20 an oncomir.

= Figure=20 2 | MicroRNAs can function as tumour = suppressors and=20 oncogenes.
=

a | In normal tissues, proper microRNA (miRNA) = transcription, processing and binding to complementary sequences on the = target=20 mRNA results in the repression of target-gene expression through a block = in=20 protein translation or altered mRNA stability (not shown). The overall = result is=20 normal rates of cellular growth, proliferation, differentiation and cell = death.=20 b | The reduction or deletion of a miRNA that = functions as=20 a tumour suppressor leads to tumour formation. A reduction in or = elimination of=20 mature miRNA levels can occur because of defects at any stage of miRNA=20 biogenesis (indicated by question marks) and ultimately leads to the=20 inappropriate expression of the miRNA-target oncoprotein (purple = squares). The=20 overall outcome might involve increased proliferation, invasiveness or=20 angiogenesis, decreased levels of apoptosis, or undifferentiated or=20 de-differentiated tissue, ultimately leading to tumour formation. c | The amplification or overexpression of a miRNA that = has an=20 oncogenic role would also result in tumour formation. In this situation, = increased amounts of a miRNA, which might be produced at inappropriate = times or=20 in the wrong tissues, would eliminate the expression of a miRNA-target=20 tumour-suppressor gene (pink) and lead to cancer progression. Increased = levels=20 of mature miRNA might occur because of amplification of the miRNA gene, = a=20 constitutively active promoter, increased efficiency in miRNA processing = or=20 increased stability of the miRNA (indicated by question marks). ORF, = open=20 reading frame.


= Table=20 1 | MicroRNAs that are associated with = human=20 cancers
=

The first indication that miRNAs could function as = tumour=20 suppressors came from a report by Calin et al. = that showed=20 that patients who were diagnosed with a common form of adult leukaemia, = B-cell=20 chronic lymphocytic leukemia (CLL), often have deletions or = downregulation of=20 two clustered miRNA genes, mir-15a and mir-16-1 (Ref. 93= ).=20 Deletions within the 13q14 locus occur in more than 65% of CLL cases, as = well as=20 in 50% of mantle cell lymphomas, 16=9640% of multiple = myelomas=20 and 60% of prostate=20 cancers. Therefore, it was predicted that a tumour-suppressor gene = must=20 reside in this 30-kb region. Interestingly, mir-15a and=20 mir-16-1 map within the intron of a = non-protein-coding RNA=20 gene of unknown function, which is called LEU2. Clinicians had previously noted that CLL = patients with=20 13q14 deletions have a more favourable prognosis than those with = abnormal=20 karyotypes or deletions at other loci such as 11q23 or 17p13. This might = be due=20 to the fact that homologues of mir-15a and mir-16-1 that are clustered on chromosome 3 (mir-15b and mir-16-2, respectively) continue to be expressed at = low=20 levels in patients with CLL; therefore, 13q14 deletions do not lead to = the=20 complete elimination of these miRNA families.

A recent report by Cimmino et al. = showed that=20 miR-15a and miR-16-1 negatively regulate BCL2, which is an anti-apoptotic gene that is often = over-expressed in many types of human cancers, including leukaemias and=20 lymphomas94= .=20 Therefore, it is thought that the deletion or downregulation of mir-15a and mir-16-1 results in = increased=20 expression of BCL2, promoting leukaemogenesis and lymphomagenesis in=20 haematopoietic cells. The tumour-suppressor role of miR-16 is further = supported=20 by the finding that two patients with CLL carried a germline C to T = mutation 7=20 base-pairs downstream of the mir-16-1 precursor, = resulting=20 in decreased miR-16-1 expression levels95= .=20 Although further characterization of the biological functions of miR-15 = and=20 miR-16-1 have not been completed, evidence indicates that mir-16-1 expression is preferentially downregulated in = various=20 leukaemias but not in cancers that originate from other tissues. This = supports a=20 role for this miRNA in the immune system and B-cell = differentiation93= ,=20 96= ,=20 97= ,=20 98= ,=20 99= ,=20 1= 00.

Additional studies have shown a strong correlation = between=20 abrogated expression of miRNAs and oncogenesis. For example, mature = miRNA levels=20 of miR-143 and miR-= 145=20 are significantly reduced in colore= ctal=20 tumours97= .=20 Interestingly, the hairpin precursor transcripts of these miRNAs were = detected=20 in similar quantities in normal and tumour tissues, indicating that the=20 processing of mir-143 and mir-145=20 might be disrupted in these cancer samples. However, the = tumour-suppressor roles=20 of miR-143 and miR-145 might not be specific to colorectal tissue as = their=20 expression is also downregulated in breast, prostate, cervical and = lymphoid=20 cancer cell lines84= ,=20 97= .=20 Another report demonstrated that miR-= 21=20 is upregulated in glioblastoma<= SUP>1= 01.=20 This gene was found to be expressed at a 5=96100-fold higher rate in = gliomas than=20 in normal tissue. Antisense studies of miR-21 in glioblastoma cell lines = showed=20 that this miRNA controls cell growth by inhibiting apoptosis but does = not affect=20 cell proliferation, which implies an oncogenic role for this miRNA. An=20 independent study that used microarray analysis to compare the = expression of 245=20 miRNAs in glio-blastoma versus normal tissues also identified miR-21 = levels as=20 being increased in glioblastoma tumours1= 00.=20 However, as mir-21 is not a brain-specific = gene1= 00=20 and miR-21 expression is increased in human breast cancer samples84= ,=20 this miRNA might have a wider function in tumour progression. More = studies need=20 to be done to show whether these miRNAs have a direct function in cancer = progression or are simply differentially modulated in tumours.

The let-7 family negatively regulates Ras

The miRNAs that are encoded by the let-7=20 family were the first group of oncomirs shown to regulate the expression = of an=20 oncogene, specifically the Ras genes. Ras proteins are = membrane-associated=20 GTPase signalling proteins that regulate cellular growth and = differentiation.=20 About 15=9630% of human tumours possess mutations in Ras genes, and = activating=20 mutations that result in the increased expression of Ras cause cellular=20 transformation. Therefore, a miRNA that regulates the expression level = of these=20 potentially oncogenic proteins is predicted to keep the rate of cellular = proliferation in check. The miRNAs that are encoded by the let-7 family, which include 12 human homologues, were = implicated=20 as tumour suppressors because they map to fragile sites associated with = lung,=20 breast, urothelial= and=20 cervical cancers83= .=20 More direct evidence, presented by Takamizawa et = al.,=20 showed that transcripts of certain let-7 = homologues were=20 significantly downregulated in human lung cancer and that this = correlated with a=20 poor prognosis81= .=20 These studies further indicate that let-7 could = be used=20 diagnostically, as patients with non-small-cell lung carcinomas who = expressed=20 lower levels of let-7 had a poorer prognosis and = shortened=20 post-operative survival. In vitro tissue-culture=20 experiments with a human lung adenoma cell line that showed that = transient=20 delivery of let-7 can inhibit cellular = proliferation also=20 indicates that let-7 probably is a = tumour-suppressor gene=20 in lung tissue. Therefore, let-7 could be used=20 therapeutically to treat lung cancer81= .

Clues to how the let-7 family = controls=20 cellular proliferation came from studies in C. = elegans in=20 our laboratory. We showed that certain members of the let-7=20 family genetically interact with oncogenic Ras and that the let-7 family and Ras are reciprocally expressed. = Moreover, the 3'=20 UTR of Ras genes contains multiple complementary sites for the let-7 family60= ,=20 82= .=20 We also found that let-7 negatively regulates Ras = in human=20 cells. Overexpression of let-7 in human cancer = cell lines=20 results in decreased levels of Ras compared with untreated cells. = Conversely,=20 the depletion of RNA levels of let-7 in human = cancer cell=20 lines that normally express high levels leads to a marked increase in = Ras=20 protein expression82= .=20 We also provided evidence that let-7 directly = controls Ras=20 expression through 3'-UTR-mediated repression in human cells. Reporter=20 constructs that contain Ras 3' UTRs were downregulated at the = translational=20 level by let-7, and let-7 = inhibitors=20 could reverse this repression. Furthermore, when comparing lung tumours = to=20 normal adjacent cells taken from patients with squamous-cell carcinoma = of the=20 lung, let-7 and Ras genes were reciprocally = expressed:=20 let-7 homologues were downregulated in the = tumours, whereas=20 Ras was highly expressed.

Taken together, these studies indicate that let-7 is a promising therapeutic agent to treat lung = cancers=20 caused by activating mutations in Ras genes. Interestingly, repression = of let-7 might be a unique characteristic of lung cancer=20 progression. Analysis of the expression of let-7 = in 21=20 different cancer patients, 12 of whom suffered from lung cancer, = revealed that=20 let-7 was markedly reduced in all lung cancer = samples but=20 was only sporadically decreased in other tumour types. In support of = this=20 finding, microarray analysis of the expression profile of 167 miRNAs in = lung=20 tumours showed that most miRNA genes were not dramatically modulated in = lung=20 cancer82= .

miRNAs = associated with=20 the MYC oncogene

The MYC oncogene, which encodes a basic = helix-loop-helix=20 transcription factor, is often mutated or amplified in human cancers and = has=20 been shown to function as an important regulator of cell growth owing to = its=20 ability to induce both cell proliferation and apoptosis1= 02.=20 Interestingly, there seems to be a close relationship between miRNAs and = the=20 increased expression of MYC, and this leads to the development of B-cell = malignancies. For example, an aggressive B-cell leukaemia occurs when = MYC is translocated into the mir-142 locus. This t(8;17) translocation places = MYC just downstream of the miRNA hairpin sequences and = under the=20 control of the miRNA promoter41= .=20 Loss of a conserved region of about 20 nucleotides, which is downstream = of the=20 mir-142 precursor, on MYC=20 translocation is thought to disrupt miRNA processing, leading to the = increased=20 expression of MYC and the transformation of B cells.

Another miRNA, miR-= 155,=20 has also been linked with MYC overexpression and B-cell cancers. This = miRNA is=20 encoded by nucleotides 241=96262 of BIC. This gene was initially identified as a common = integration site for the avian leukosis virus and was found to be = overexpressed=20 in B-cell lymphomas1= 03,=20 1= 04.=20 For years, researchers were puzzled as to how an RNA that was presumably = not=20 protein-coding, and was poorly conserved between avian, mouse and human = genomes,=20 could promote lymphomas in cells that also overexpressed MYC. Metzler = et al. found that the only phylogenetically conserved = region=20 within BIC spans 138 nucleotides and encodes the = hairpin=20 region of mir-155 (Ref. 1= 05).=20 This group then showed that miR-155 expression is upregulated 100-fold = in=20 paediatric B= urkitt=20 lymphoma, and other studies showed increased miR-155 levels in Hodgki= n=20 lymphoma and in primary mediastinal and diffuse large-B-cell = lymphomas with=20 activated rather than germinal-centre phenotypes1= 06,=20 1= 07,=20 1= 08.=20 Therefore, it seems that mir-155 can function as = an=20 oncogene in cooperation with MYC, whereas it = normally=20 functions during B-cell selection and possibly targets genes that = antagonize the=20 MYC pathway.

miR-155 has also been reported to be upregulated in = breast=20 carcinomas, which indicates that there are further roles for this gene = outside=20 of the haematopoietic system84= .=20 Furthermore, the organization of the mir-155/BIC = gene is=20 reminiscent of the mir-15a and mir-16-1 genes, which are encoded within the intron of = the=20 non-protein-coding LEU2 gene, as well as the C13orf25 gene, which contains the mir-17=9692 cluster that is described below. However, = the=20 significance of a non-protein-coding RNA harbouring miRNAs within a = transcript=20 and being linked to oncogenesis is unclear.

Two recent papers from He et al. = and=20 O'Donnell et al. describe a more direct = relationship=20 between miRNAs, MYC and cancer1= 09,=20 1= 10.=20 The 13q31 locus is preferentially amplified in cancers such as diffuse=20 large-B-cell lymphoma, follicular lymphoma, mantle cell lymphoma and = primary=20 cutaneous B-cell lymphoma. However, the only gene that has been found to = be=20 upregulated within this amplicon is a non-protein-coding RNA, C13orf25 (Ref. 11= ).=20 This transcript was shown to encode the mir-17=9692 cluster,=20 which includes seven miRNAs: miR-= 17-5p,=20 miR-17-3p, miR-= 18a,=20 miR-= 19a,=20 miR-= 20a,=20 miR-= 19b-1=20 miR-= 92-1.=20 He and colleagues analysed cell lines carrying an amplification of 13q31 = for the=20 expression of 191 miRNAs and found that 6 miRNAs had increased = expression, which=20 corresponded to more copies of C13orf25, and 5 of = these=20 belonged to the mir-17=9692 cluster1= 09.=20 This group then showed that the pri-miRNA for the mir-17=9692=20 cluster was upregulated in 65% of B-cell lymphoma samples that were = tested. They=20 therefore postulated that increased expression of this cluster = contributes to=20 cancer formation.

To test this directly, the researchers overexpressed the = mir-17=9619b-1 cluster (the vertebrate-specific portion = of the=20 mir-17=9692 cluster) using a retroviral system in = haematopoietic stem cells (HSCs) that had been isolated from mice = carrying the=20 Myc transgene. Wild-type mice were given a = sublethal dose=20 of radiation to wipe out the bone marrow and were then transplanted with = the=20 retrovirally transduced HSCs. Irradiated animals that received HSCs=20 overexpressing both Myc and the mir-17=9619b-1 cluster developed malignant lymphomas = faster (51=20 days) than those animals that received HSCs expressing Myc=20 alone (3=966 months). Interestingly, similar experiments that used HSCs=20 overexpressing Myc in combination with either 96 = unrelated,=20 single miRNAs or any individual miRNA of the mir-17=9619b-1=20 cluster did not show accelerated onset of disease. Lymphomas that = resulted from=20 the increased expression of both MYC and mirRNAs from the mir-17=9619b-1 cluster had increased cell proliferation = and lower=20 levels of cell death in comparison with latent malignancies that arose = from=20 increased MYC expression levels alone, which underwent extensive = apoptosis.

These experiments indicate that miRNAs within the = truncated mir-17=9619b-1 cluster function cooperatively as = oncogenes,=20 possibly by targeting apoptotic factors that are activated in response = to MYC=20 overexpression. When the brakes of the apoptotic pathway are removed, = MYC can=20 induce cells to proliferate uncontrollably, which results in cancer. The = oncogenic function of the mir-17=9692 cluster is = further=20 validated by the fact that miR-19a and miR-92-1 expression levels are = increased=20 in cells from patients with B-cell CLL, that miRNAs from the mir-17=9692 cluster are overexpressed in lung cancers = and that=20 C13orf25 is frequently amplified in alveolar=20 rhabdomyosarcoma and liposarcoma1= 11,=20 1= 12,=20 1= 13,=20 1= 14,=20 1= 15,=20 1= 16.

O'Donnell et al. independently = identified the=20 mir-17=9692 cluster as a group of potentially = cancer-related=20 genes when they carried out a microarray screen of 235 human, mouse and = rat=20 miRNAs to identify miRNAs that were modulated in a human B-cell line, = P493-6,=20 that overexpresses MYC1= 10.=20 This study showed that MYC induces the expression of the mir-17=9692 cluster, and chromatin immunoprecipitation = experiments=20 revealed that MYC binds within the first intron of C13orf25, which implies that MYC directly regulates the = mir-17=9692 pri-miRNA transcript. The next step was to = identify=20 gene targets of the MYC-regulated mir-17=9692 = cluster.=20 Previous bioinformatic studies had identified the transcription factor = E2F1 as a target of two = miRNAs=20 within this cluster =97 miR-17-5p and miR-20a. E2F1 controls the = transition from=20 G1 to S phase of the cell cycle by regulating genes that are involved in = DNA=20 replication, cell division and apoptosis1= 17.

Interestingly, E2F1 is known to function in a reciprocal = positive-feedback loop with MYC. O'Donnell et al. = found=20 that inhibition of mir-17-5p and mir-20a in a cervical cancer cell line markedly = increased E2F1=20 expression levels without affecting mRNA abundance, which is a hallmark = of=20 miRNA-mediated gene repression. Mutations of sites in the E2F1 3' UTR that are complementary to mir-17-5p and = mir-20a=20 resulted in increased reporter activity compared with those that result = from=20 wild-type constructs. Taken together, these studies show that MYC = induces the=20 transcription of both the mir-17=9692 cluster and = E2F1, and, in turn, these miRNAs negatively regulate = the=20 translation of E2F1. Therefore, a model is proposed in which = MYC-mediated cell=20 growth is tightly regulated by the mir-17=9692 = cluster. In=20 the presence of MYC, miRNAs of the mir-17=9692 = cluster limit=20 the activity of E2F1 and dampen the cell-proliferative effects of MYC by = breaking the positive-feedback loop between MYC and E2F1. In this = context the=20 mir-17=9692 cluster would function as a tumour = suppressor,=20 which is in contrast to the findings of He et al. = that are=20 discussed above. Consistent with this model, which was proposed by = O'Donnell and=20 colleagues, loss of heterozygosity at the 13q31 loci that encodes the = mir-17=9692 cluster has been reported in hepatocellular=20 carcinomas1= 18.=20 However, it has also been reported that although E2F1 drives cell-ular=20 proliferation, when E2F1 expression levels cross a certain threshold, = excessive=20 levels of this protein induce apoptosis1= 17.=20 In this context, the negative regulation of E2F1 by miRNAs of the mir-17=9692 cluster might function to block the = apoptotic activity=20 of E2F1 and stimulate MYC-mediated cellular proliferation, so supporting = the=20 model that was proposed by He et al.

The tumour-suppressing and oncogenic nature of the mir-17=9692 cluster emphasizes the complexities of = cancer=20 progression as well as the intricacies of miRNA-mediated gene = regulation. These=20 results might also reflect the fact that a single miRNA can control many = unrelated gene targets, resulting in the control of opposing activities = such as=20 cellular proliferation and differentiation. Perhaps the ability of the = mir-17=9692 cluster to function as either tumour = suppressors or=20 oncogenes depends on which cell types these miRNAs are expressed in and = what=20 tissue-specific target mRNAs are present to be regulated. Future studies = might=20 reveal that miRNAs function as key regulators of many cancer-related = genes as=20 well as BCL2, Ras and E2F1. In fact, a=20 recent report by Felli et al. described the = ability of miR-= 221=20 and miR-= 222=20 to downregulate the KIT oncogene to modulate erythropoiesis of = CD34+=20 HPCs and inhibit cell growth of an erythroleukaemic TF-1 cell line in a=20 KIT-dependent manner1= 19.=20 In support of the regulatory role of the KIT = oncogene by=20 miRNAs, He et al. found that patients with = papillary=20 thyroid carcinomas showed decreased KIT = transcript and=20 protein levels and reciprocally increased levels of miR-221, miR-222, = and=20 miR-146 in the tumours, implicating that these miRNAs act as oncogenes = in this=20 setting1= 32.=20 The study also showed that five out of ten papillary thyroid carcinomas = showed=20 point mutations in the KIT loci specifically = within the=20 complimentary binding regions for miR-221, miR-222, and miR-146 and = therefore=20 altered the miRNA=96target interactions in these tumours. More work will = need to=20 be done in order to understand how these miRNAs contribute to cancer = progression=20 by downregulating the KIT oncogene. Therefore, = miRNAs might=20 be powerful drug targets that could be used in a broad range of cancer=20 therapies.

miRNA = profiling=20 might aid cancer diagnosis

Northern-blot analyses and miRNA microarrays have been = useful in=20 determining tissue-specific 'signatures' of miRNA genes in humans37= ,=20 44= ,=20 46= ,=20 96= ,=20 1= 20,=20 1= 21,=20 1= 22,=20 1= 23,=20 1= 24,=20 1= 25,=20 1= 26,=20 1= 27,=20 1= 28.=20 The distinct miRNA-expression profiles that have been observed in = certain organs=20 underscore the importance of miRNAs in stem-cell maintenance and in = directing=20 the differentiation of certain cell types during development. = Researchers are=20 now using miRNA-expression signatures to classify cancers and to define = miRNA=20 markers that might predict favourable prognosis81= ,=20 84= ,=20 95= ,=20 98= ,=20 1= 00,=20 1= 01,=20 1= 09,=20 1= 10,=20 1= 12.

A recent report from Lu et al. = found that the=20 expression profiles of relatively few miRNAs (200=20 genes), were required to accurately classify human cancers98= .=20 This group designed a novel method, which is based on bead-based=20 flow cytometry, to study the expression of miRNAs in both normal and = cancerous tissues. Tumours that originated from various tissues were = clustered=20 solely on the basis of their miRNA-expression profiles. This resulted in = tumours=20 being grouped according to their embryonic lineage. For example, tumours = of=20 endothelial origin such as colon, liver, pancreas= and stomach = were=20 clustered together, and tumours of haematopoietic origin also clustered=20 together. Interestingly, when the expression profiles of about 16,000=20 protein-coding mRNA genes were analysed in the same tumour dataset, = hierarchical=20 clustering was unable to group tumours in a coherent manner =97 for = example,=20 gastrointestinal-derived tumours could not be grouped together. = Therefore, miRNA=20 signatures within tumours reflect their developmental history, a = hypothesis that=20 is compatible with the evidence that miRNAs direct tissue-specific = developmental=20 functions.

These researchers also compared the miRNA-expression = profiles of=20 tumour samples versus normal tissue and found that 129 out of 217 miRNAs = had a=20 lower level of expression in tumours regardless of the tissue of origin. = Therefore, in a global sense, miRNAs might function to drive cells into = a more=20 differentiated state, and the expression profiles of miRNAs in tumours = compared=20 with normal tissues might represent the degree of differentiation in = those=20 cells. These studies establish miRNAs as 'oncomirs' and imply that = abnormalities=20 in miRNA expression might directly result in the de-differentiation of = cells,=20 allowing tumour formation to occur.

An established library of miRNA signatures or = miRNA-expression=20 profiles, assigned for each class of tumour, might help both the = diagnosis and=20 treatment of cancer. These libraries could easily be established as = miRNAs can=20 be isolated from formalin-fixed paraffin-embedded archival = tissues1= 20.=20 The differential expression of certain miRNAs has already been shown to = be an=20 accurate predictor of a patient's overall prognosis. From a therapeutic=20 standpoint, miRNA-expression profiling might prove to be a powerful tool = for=20 clinicians when defining a treatment regimen for their patients. As = proof of=20 principle, Lu et al. found that miRNA signatures = could=20 successfully categorize poorly differentiated tumours that were = considered=20 histologically non-diagnostic into their appropriate tissue-specific=20 lineages98= .

Future = approaches=20 using miRNA therapies

The emergence of miRNAs as important cancer-prevention = genes is=20 likely to have a large effect on gene therapies that are designed to = block=20 tumour progression. Large-scale expression screens, similar to those = described=20 above that compare miRNA levels in tumours versus normal tissues, will = be useful=20 in identifying novel miRNAs that are involved in cancer. Also, = functional=20 screens that are designed to select miRNA genes that specifically = control=20 cancer-related processes such as cell proliferation and apoptosis, = similar to=20 those that were conducted by Cheng et al.99= ,=20 will also help in this search. In the future, the administration of = synthetic=20 anti-sense oligonucleotides that encode sequences that are complementary = to=20 mature oncogenic miRNAs =97 termed anti-miRNA=20 oligonucleotides (AMOs) =97 might effectively inactivate miRNAs in = tumours and=20 slow their growth. In the clinic, miRNA inactivation could be = accomplished=20 through frequent or continuous delivery of 2'-O-methyl or=20 locked-nucleic-acid antisense oligonucleotides, which are specifically = designed=20 to be more stable and less toxic than other cancer treatments in order = to target=20 transforming miRNAs such as mir-155.

The use of antagomirs, which are AMOs that are = conjugated with=20 cholesterol, has recently emerged as an effective approach to inhibit = miRNA=20 activity in various organs when injected into mice, and might be = promising=20 therapeutic agents1= 29.=20 Conversely, techniques to overexpress miRNAs that function as tumour=20 suppressors, such as those that are encoded by the let-7=20 family, could be used to treat specific tumour types. Transient = expression=20 systems that use viral or liposomal delivery might be useful approaches = for=20 administering large quantities of miRNAs. These techniques would involve = expressing the pre-miRNA hairpin and flanking sequences, potentially = under the=20 control of tissue-specific promoters, to stimulate the endogenous miRNA=20 machinery to direct proper miRNA processing and gene-targeted = repression.=20 However, employing similar methods that use siRNAs as cancer gene = therapies have=20 shown that the immune response can limit the effectiveness of RNA=20 delivery1= 30,=20 1= 31.=20 More development of these methods is needed before miRNA treatments can = move=20 from the laboratory bench to the bedside. Whether miRNAs become the = 'magic=20 bullet' of the future remains to be seen, but research in this area will = undoubtedly provide insight into the underlying mechanisms of=20 oncogenesis.

To= p of page

Acknowledgements

We thank Helge Grosshans and Diya Banerjee for critical = reading of=20 the manuscript. F.J.S. is supported by grants from the National Science=20 Foundation and the National Institutes of Health and A.E.-K. is = supported by a=20 Ruth L. Kirschstein National Research Service Award Individual = Postdoctoral=20 Fellowship.

Competing interests statement

The authors declare no competing financial=20 interests.

To= p of page

References

  1. Bartel, D. P. MicroRNAs: = genomics,=20 biogenesis, mechanism, and function. Cell 116, 281=96297 (2004).
    An excellent review of = plant and=20 animal miRNAs that discusses how miRNAs differ from siRNAs.

  2. Hannon, G. J. RNA = interference. Nature 418, 244=96251 = (2002).

  3. Llave, C., Xie, Z., Kasschau, K. D. & = Carrington, J. C.=20 Cleavage of Scarecrow-like mRNA targets directed by = a class of=20 Arabidopsis miRNA. Science = 297, 2053=962056 (2002).

  4. Palatnik, J. F. et al. Control of leaf=20 morphogenesis by microRNAs. Nature = 425, 257=96263 (2003).

  5. Tang, G., Reinhart, B. J., Bartel, D. P. & = Zamore, P. D.=20 A biochemical framework for RNA silencing in = plants.=20 Genes Dev. 17, = 49=9663 (2003).

  6. Yekta, S., Shih, I. H. & Bartel, D. P. MicroRNA-directed cleavage of HOXB8 mRNA. = Science 304, 594=96596 = (2004).

  7. Carmell, M. A., Xuan, Z., Zhang, M. Q. & = Hannon, G. J.=20 The Argonaute family: tentacles that reach into = RNAi,=20 developmental control, stem cell maintenance, and = tumorigenesis. Genes Dev. 16, 2733=962742 = (2002).

  8. Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 = encodes small=20 RNAs with antisense complementarity to lin-14. Cell 75, 843=96854 (1993).

  9. Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene=20 lin-14 by lin-4 mediates temporal pattern formation in = C.=20 elegans. Cell 75,=20 855=96862 (1993).

  10. Olsen, P. H. & Ambros, V. The = lin-4 regulatory RNA controls developmental timing in = Caenorhabditis=20 elegans by blocking LIN-14 protein synthesis after the initiation = of=20 translation. Dev. Biol. 216, 671=96680 (1999).

  11. Ambros, V. Control of = developmental timing in=20 Caenorhabditis elegans. Curr. Opin. = Genet.=20 Dev. 10, 428=96433 (2000).

  12. Reinhart, B. et al. The 21 = nucleotide=20 let-7 RNA regulates C. elegans developmental = timing.=20 Nature 403, = 901=96906 (2000).

  13. Slack, F. J. et al. The = lin-41=20 RBCC gene acts in the C. elegans heterochronic pathway between = the=20 let-7 regulatory RNA and the lin-29 transcription = factor.=20 Mol. Cell 5, = 659=96669 (2000).

  14. Pasquinelli, A. E. & Ruvkun, G. Control=20 of developmental timing by micrornas and their targets. Annu. Rev. Cell Dev. Biol. 18, 495=96513=20 (2002).

  15. Abrahante, J. E. et al. The=20 Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 = controls=20 developmental time and is regulated by microRNAs. Dev.=20 Cell 4, 625=96637 (2003).

  16. Lin, S. Y. et al. The C = elegans=20 hunchback homolog, hbl-1, controls temporal patterning and is a = probable microRNA target. Dev. Cell = 4, 639=96650 (2003).

  17. Brennecke, J., Hipfner, D. R., Stark, A., Russell, = R. B.=20 & Cohen, S. M. bantam encodes a = developmentally=20 regulated microRNA that controls cell proliferation and regulates the=20 proapoptotic gene hid in Drosophila. Cell 113, 25=9636 (2003).

  18. Pillai, R. S. et al. Inhibition of=20 translational initiation by let-7 microRNA in human cells. = Science 309, 1573=961576 = (2005).

  19. Bagga, S. et al. Regulation by=20 let-7 and lin-4 miRNAs results in target mRNA=20 degradation. Cell 122,=20 553=96563 (2005).

  20. Lim, L. P. et al. Microarray analysis=20 shows that some microRNAs downregulate large numbers of target = mRNAs.=20 Nature 433, = 769=96773 (2005).

  21. Lee, Y., Jeon, K., Lee, J. T., Kim, S. & Kim, = V. N. MicroRNA maturation: stepwise processing and subcellular=20 localization. EMBO J. 21,=20 4663=964670 (2002).

  22. Basyuk, E., Suavet, F., Doglio, A., Bordonne, R. = &=20 Bertrand, E. Human let-7 stem-loop precursors = harbor=20 features of RNase III cleavage products. Nucleic Acids=20 Res. 31, 6593=966597 (2003).

  23. Lee, Y. et al. The nuclear = RNase III=20 Drosha initiates microRNA processing. Nature=20 425, 415=96419 (2003).

  24. Zeng, Y. & Cullen, B. R. Sequence=20 requirements for microRNA processing and function in human = cells. RNA 9, 112=96123 (2003).

  25. Gregory, R. I. et al. The=20 Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235=96240 = (2004).

  26. Lee, Y. S. et al. Distinct = roles for=20 Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing=20 pathways. Cell 117, 69=9681=20 (2004).

  27. Cai, X., Hagedorn, C. H. & Cullen, B. R. Human microRNAs are processed from capped, polyadenylated=20 transcripts that can also function as mRNAs. RNA=20 10, 1957=961966 (2004).

  28. Denli, A. M., Tops, B. B., Plasterk, R. H., = Ketting, R. F.=20 & Hannon, G. J. Processing of primary microRNAs = by the=20 Microprocessor complex. Nature 432, 231=96235 (2004).

  29. Lund, E., Guttinger, S., Calado, A., Dahlberg, J. = E. &=20 Kutay, U. Nuclear export of microRNA = precursors. Science 303, 95=9698 = (2004).

  30. Yi, R., Qin, Y., Macara, I. G. & Cullen, B. R. = Exportin-5 mediates the nuclear export of pre-microRNAs = and short=20 hairpin RNAs. Genes Dev. 17, 3011=963016 (2003).

  31. Bohnsack, M. T., Czaplinski, K. & Gorlich, D. = Exportin 5 is a RanGTP-dependent dsRNA-binding protein = that mediates=20 nuclear export of pre-miRNAs. RNA = 10, 185=96191 (2004).

  32. Grishok, A. et al. Genes = and=20 mechanisms related to RNA interference regulate expression of small = temporal=20 RNAs that control C. elegans developmental timing. Cell 106, 23=9634 (2001).

  33. Hutvagner, G. et al. A = cellular=20 function for the RNA-interference enzyme Dicer in the maturation of = the=20 let-7 small temporal RNA. Science 293, 834=96838 (2001).

  34. Ketting, R. F. et al. Dicer functions=20 in RNA interference and in synthesis of small RNA involved in = developmental=20 timing in C. elegans. Genes = Dev. 15, 2654=962659 (2001).

  35. Feinbaum, R. & Ambros, V. The = timing of=20 lin-4 RNA accumulation controls the timing of postembryonic=20 developmental events in Caenorhabditis elegans. Dev. Biol. 210, 87=9695 = (1999).

  36. Ambros, V. & Horvitz, H. R. Heterochronic=20 mutants of the nematode Caenorhabditis elegans. Science 226, 409=96416 = (1984).

  37. Pasquinelli, A., Reinhart, B., Slack, F., Maller, = B. &=20 Ruvkun, G. Conservation across animal phylogeny of = the=20 sequence and temporal regulation of the 21 nucleotide C. elegans = let-7=20 heterochronic regulatory RNA. Nature = 408, 86=9689 (2000).

  38. Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & = Tuschl,=20 T. Identification of novel genes coding for small = expressed=20 RNAs. Science 294,=20 853=96858 (2001).

  39. Lau, N. C., Lim, L. P., Weinstein, E. G. & = Bartel, D. P.=20 An abundant class of tiny RNAs with probable = regulatory roles=20 in Caenorhabditis elegans. Science 294, 858=96862. (2001).

  40. Lee, R. C. & Ambros, V. An = extensive=20 class of small RNAs in Caenorhabditis elegans. Science 294, 862=96864 = (2001).

  41. Lagos-Quintana, M. et al. Identification of tissue-specific microRNAs from = mouse. Curr. Biol. 12, 735=96739 = (2002).

  42. Aravin, A. A. et al. The = small RNA=20 profile during Drosophila melanogaster development. = Dev. Cell 5, 337=96350 = (2003).

  43. Johnston, R. J. & Hobert, O. A microRNA=20 controlling left/right neuronal asymmetry in Caenorhabditis=20 elegans. Nature 426,=20 845=96849 (2003).

  44. Lagos-Quintana, M., Rauhut, R., Meyer, J., = Borkhardt, A.=20 & Tuschl, T. New microRNAs from mouse and = human.=20 RNA 9, 175=96179 = (2003).

  45. Lai, E. C., Tomancak, P., Williams, R. W. & = Rubin, G. M.=20 Computational identification of Drosophila = microRNA=20 genes. Genome Biol. 4,=20 R42 (2003).

  46. Lim, L. P., Glasner, M. E., Yekta, S., Burge, C. B. = &=20 Bartel, D. P. Vertebrate microRNA genes. = Science 299, 1540 (2003).

  47. Lim, L. P. et al. The = microRNAs of=20 Caenorhabditis elegans. Genes = Dev. 17, 991=961008 (2003).

  48. Sempere, L. F., Sokol, N. S., Dubrovsky, E. B., = Berger, E. M.=20 & Ambros, V. Temporal regulation of microRNA = expression in=20 Drosophila melanogaster mediated by hormonal signals and = Broad=96Complex=20 gene activity. Dev. Biol. 259, 9=9618 (2003).

  49. Xu, P., Vernooy, S. Y., Guo, M. & Hay, B. A. = The Drosophila microRNA mir-14 suppresses cell = death and is=20 required for normal fat metabolism. Curr. = Biol.=20 13, 790=96795 (2003).

  50. Chang, S., Johnston, R. J. Jr, Frokjaer-Jensen, C., = Lockery,=20 S. & Hobert, O. MicroRNAs act sequentially and=20 asymmetrically to control chemosensory laterality in the = nematode.=20 Nature 430, = 785=96789 (2004).

  51. Berezikov, E. et al. Phylogenetic=20 shadowing and computational identification of human microRNA = genes.=20 Cell 120, 21=9624 = (2005).

  52. Bentwich, I. et al. Identification of=20 hundreds of conserved and nonconserved human microRNAs. Nature Genet. 37, = 766=96770 (2005).

    • Article
      • <= /UL>

    • Rodriguez, A., Griffiths-Jones, S., Ashurst, J. L. = &=20 Bradley, A. Identification of mammalian microRNA = host genes=20 and transcription units. Genome Res. = 14, 1902=961910 (2004).

    • Baskerville, S. & Bartel, D. P. Microarray profiling of microRNAs reveals frequent = coexpression with=20 neighboring miRNAs and host genes. RNA = 11, 241=96247 (2005).

    • Khvorova, A., Reynolds, A. & Jayasena, S. D. = Functional siRNAs and miRNAs exhibit strand bias. = Cell 115, 209=96216 (2003).

    • Schwarz, D. S. et al. Asymmetry in the=20 assembly of the RNAi enzyme complex. Cell 115, 199=96208 (2003).

    • Doench, J. G. & Sharp, P. A. Specificity=20 of microRNA target selection in translational repression. Genes Dev. 18, 504=96511 = (2004).

    • Vella, M. C., Choi, E. Y., Lin, S. Y., Reinert, K. = &=20 Slack, F. J. The C. elegans microRNA = let-7 binds=20 to imperfect let-7 complementary sites from the lin-41 = 3'=20 UTR. Genes Dev. 18,=20 132=96137 (2004).

    • Brennecke, J., Stark, A., Russell, R. B. & = Cohen, S. M.=20 Principles of microRNA-target recognition. = PLoS Biol. 3, e85 (2005).

    • Grosshans, H., Johnson, T., Reinert, K. L., = Gerstein, M.=20 & Slack, F. J. The temporal patterning microRNA=20 let-7 regulates several transcription factors at the larval to = adult=20 transition in C. elegans. Dev. = Cell 8, 321=96330 (2005).

    • Krek, A. et al. Combinatorial microRNA=20 target predictions. Nature Genet. = 37, 495=96500 (2005).

      • Article
        • <= /UL>

      • Rehmsmeier, M., Steffen, P., Hochsmann, M. & = Giegerich,=20 R. Fast and effective prediction of microRNA/target=20 duplexes. RNA 10,=20 1507=961517 (2004).

      • John, B. et al. Human = microRNA=20 targets. PLoS Biol. 2,=20 e363 (2004).

      • Kiriakidou, M. et al. A = combined=20 computational=96experimental approach predicts human microRNA = targets.=20 Genes Dev. 18, = 1165=961178 (2004).

      • Enright, A. J. et al. MicroRNA targets=20 in Drosophila. Genome Biol. = 5, R1 (2003).

      • Rajewsky, N. & Socci, N. D. Computational=20 identification of microRNA targets. Dev. = Biol.=20 267, 529=96535 (2004).

      • Stark, A., Brennecke, J., Russell, R. B. & = Cohen, S. M.=20 Identification of Drosophila microRNA = targets.=20 PLoS Biol. 1, E60 = (2003).

      • Lewis, B. P., Shih, I. H., Jones-Rhoades, M. W., = Bartel, D.=20 P. & Burge, C. B. Prediction of mammalian = microRNA=20 targets. Cell 115,=20 787=96798 (2003).

      • Vella, M. C., Reinert, K. & Slack, F. J. Architecture of a validated microRNA::target = interaction.=20 Chem. Biol. 11, = 1619=961623 (2004).

      • Hobert, O. Common logic of = transcription=20 factor and microRNA action. Trends Biochem. = Sci.=20 29, 462=96468 (2004).

      • Karube, Y. et al. Reduced = expression=20 of Dicer associated with poor prognosis in lung cancer = patients. Cancer Sci. 96, 111=96115 = (2005).

      • Kanellopoulou, C. et al. Dicer-deficient mouse embryonic stem cells are defective = in=20 differentiation and centromeric silencing. Genes=20 Dev. 19, 489=96501 (2005).

      • Fukagawa, T. et al. Dicer = is essential=20 for formation of the heterochromatin structure in vertebrate = cells.=20 Nature Cell Biol. 6, = 784=96791=20 (2004).

      • Bernstein, E. et al. Dicer = is=20 essential for mouse development. Nature = Genet.=20 35, 215=96217 (2003).

        • Article
          • <= /UL>

        • Harfe, B. D., McManus, M. T., Mansfield, J. H., = Hornstein, E.=20 & Tabin, C. J. The RNaseIII enzyme Dicer is = required for=20 morphogenesis but not patterning of the vertebrate limb. Proc. Natl Acad. Sci. USA 102,=20 10898=9610903 (2005).

        • Muljo, S. A. et al. Aberrant T cell=20 differentiation in the absence of Dicer. J. = Exp.=20 Med. 202, 261=96269 (2005).

        • Yang, W. J. et al. Dicer = is required=20 for embryonic angiogenesis during mouse development. J.=20 Biol. Chem. 280, 9330=969335 (2005).

        • Nelson, P., Kiriakidou, M., Sharma, A., Maniataki, = E. &=20 Mourelatos, Z. The microRNA world: small is = mighty.=20 Trends Biochem. Sci. 28, 534=96540=20 (2003).

        • Qiao, D., Zeeman, A. M., Deng, W., Looijenga, L. H. = &=20 Lin, H. Molecular characterization of hiwi, a = human=20 member of the piwi gene family whose overexpression is = correlated to=20 seminomas. Oncogene 21,=20 3988=963999 (2002).

        • Lee, Y. S., Kim, H. K., Chung, S., Kim, K. S. & = Dutta, A.=20 Depletion of human micro-RNA miR-125b reveals that = it is=20 critical for the proliferation of differentiated cells but not for the = down-regulation of putative targets during differentiation. = J. Biol. Chem. 280, = 16635=9616641 (2005).

        • Takamizawa, J. et al. Reduced=20 expression of the let-7 microRNAs in human lung cancers in = association=20 with shortened postoperative survival. Cancer = Res. 64, 3753=963756 (2004).
          Describes a strong = correlation=20 between expression levels of members of the let-7 family and=20 post-operative survival in patients with lung cancer, and therefore = supports=20 the notion that let-7 family members function as tumour=20 suppressors.

        • Johnson, S. M. et al. RAS is=20 regulated by the let-7 microRNA family. Cell 120, 635=96647 (2005).
          Implicates a = tumour-suppressor role=20 for the let-7 family by directly regulating the expression of = the Ras=20 oncogenes.

        • Calin, G. A. et al. Human = microRNA=20 genes are frequently located at fragile sites and genomic regions = involved in=20 cancers. Proc. Natl Acad. Sci. USA = 101, 2999=963004 (2004).
          Reveals that half the = annotated=20 human miRNAs are associated with cancer.

        • Iorio, M. V. et al. MicroRNA gene=20 expression deregulation in human breast cancer. Cancer=20 Res. 65, 7065=967070 (2005).

        • Sonoki, T., Iwanaga, E., Mitsuya, H. & Asou, N. = Insertion of microRNA-125b-1, a human homologue of=20 lin-4, into a rearranged immunoglobulin heavy chain gene locus = in a=20 patient with precursor B-cell acute lymphoblastic leukemia. = Leukemia 19, 2009=962010 = (2005).

        • Hipfner, D. R., Weigmann, K. & Cohen, S. M. = The bantam gene regulates Drosophila = growth.=20 Genetics 161, = 1527=961537 (2002).

        • Giraldez, A. J. et al. MicroRNAs=20 regulate brain morphogenesis in zebrafish. Science 308, 833=96838 = (2005).

        • Chen, C. Z., Li, L., Lodish, H. F. & Bartel, D. = P. MicroRNAs modulate hematopoietic lineage = differentiation.=20 Science 303, 83=9686 = (2004).

        • Poy, M. N. et al. A = pancreatic=20 islet-specific microRNA regulates insulin secretion. Nature 432, 226=96230 = (2004).

        • Esau, C. et al. MicroRNA-143 regulates=20 adipocyte differentiation. J. Biol. = Chem. 279, 52361=9652365 (2004).

        • Hornstein, E. et al. The = microRNA=20 miR-196 acts upstream of Hoxb8 and Shh in limb = development.=20 Nature 438, = 671=96674 (2005).

        • Zhao, Y., Samal, E. & Srivastava, D. Serum response factor regulates a muscle-specific microRNA = that=20 targets Hand2 during cardiogenesis. Nature 436, 214=96220 (2005).

        • Calin, G. A. et al. Frequent deletions=20 and down-regulation of micro-RNA genes miR15 and miR16 = at 13q14=20 in chronic lymphocytic leukemia. Proc. Natl = Acad. Sci.=20 USA 99, 15524=9615529 (2002).
          The first report to = correlate the=20 mis-expression of miRNAs with cancer.

        • Cimmino, A. et al. miR-15 and=20 miR-16 induce apoptosis by targeting BCL2. Proc.=20 Natl Acad. Sci. USA 102, 13944=9613949 = (2005).
          Provides evidence that=20 mir-15a and mir-16-1 negatively regulate the BCL2 = oncogene.

        • Calin, G. A. et al. A = microRNA=20 signature associated with prognosis and progression in chronic = lymphocytic=20 leukemia. N. Engl. J. Med. 353, 1793=961801 (2005).

        • Liu, C. G. et al. An = oligonucleotide=20 microchip for genome-wide microRNA profiling in human and mouse=20 tissues. Proc. Natl Acad. Sci. USA = 101, 9740=969744 (2004).

        • Michael, M. Z., O'Connor, S. M., van Holst = Pellekaan, N. G.,=20 Young, G. P. & James, R. J. Reduced accumulation = of=20 specific microRNAs in colorectal neoplasia. Mol. Cancer=20 Res. 1, 882=96891 (2003).
          Reveals that = mir-143 and=20 mir-145 RNA levels are often reduced in colorectal = cancer.

        • Lu, J. et al. MicroRNA = expression=20 profiles classify human cancers. Nature 435, 834=96838 (2005).
          Shows that miRNA = expression profiles=20 can cluster similar tumour types together more accurately than the = expression=20 profiles of protein-coding mRNA genes.

        • Cheng, A. M., Byrom, M. W., Shelton, J. & Ford, = L. P.=20 Antisense inhibition of human miRNAs and indications = for an=20 involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 33, = 1290=961297=20 (2005).

        • Ciafre, S. A. et al. Extensive=20 modulation of a set of microRNAs in primary glioblastoma. Biochem. Biophys. Res. Commun. 334,=20 1351=961358 (2005).

        • Chan, J. A., Krichevsky, A. M. & Kosik, K. S. = MicroRNA-21 is an antiapoptotic factor in human = glioblastoma=20 cells. Cancer Res. 65,=20 6029=966033 (2005).
          Describes a novel=20 miRNA that functions as an oncogene by modulating the apoptotic=20 pathway.

        • Pelengaris, S., Khan, M. & Evan, G. I. Suppression of Myc-induced apoptosis in =20 cells exposes multiple oncogenic properties of Myc and triggers = carcinogenic=20 progression. Cell 109,=20 321=96334 (2002).

        • Clurman, B. E. & Hayward, W. S. Multiple=20 proto-oncogene activations in avian leukosis virus-induced lymphomas: = evidence=20 for stage-specific events. Mol. Cell. = Biol.=20 9, 2657=962664 (1989).

        • Tam, W., Ben-Yehuda, D. & Hayward, W. S. bic, a novel gene activated by proviral insertions = in avian=20 leukosis virus-induced lymphomas, is likely to function through its = noncoding=20 RNA. Mol. Cell. Biol. 17,=20 1490=961502 (1997).

        • Metzler, M., Wilda, M., Busch, K., Viehmann, S. = &=20 Borkhardt, A. High expression of precursor=20 microRNA-155/BIC RNA in children with Burkitt lymphoma. = Genes Chromosomes Cancer 39, 167=96169=20 (2004).
          Identifies an miRNA = that=20 resides in the BIC gene, a non-coding RNA that has been found = to be=20 preferentially upregulated in Hodgkin lymphoma.

        • Eis, P. S. et al. Accumulation of=20 miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl Acad. Sci. USA 102,=20 3627=963632 (2005).

        • Kluiver, J. et al. BIC and = miR-155 are=20 highly expressed in Hodgkin, primary mediastinal and diffuse large B = cell=20 lymphomas. J. Pathol. 207, 243=96249 (2005).

        • van den Berg, A. et al. High=20 expression of B-cell receptor inducible gene BIC in all = subtypes of=20 Hodgkin lymphoma. Genes Chromosomes = Cancer 37, 20=9628 (2003).

        • He, L. et al. A microRNA = polycistron=20 as a potential human oncogene. Nature = 435, 828=96833 (2005).
          Shows that the = mir-17=9692=20 cluster works together with MYC and accelerates tumour progression in = a B-cell=20 lymphoma model.

        • O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., = Dang, C. V.=20 & Mendell, J. T. c-Myc-regulated microRNAs = modulate=20 E2F1 expression. Nature 435, 839=96843 (2005).
          Reveals that the = MYC oncogene=20 induces the expression of the mir-17=9692 cluster, and, in = turn, the=20 mir-17=9692 cluster negatively regulates the MYC-target gene,=20 E2F1, revealing a complex genetic circuit that tightly controls = cellular proliferation.

        • Ota, A. et al. Identification and=20 characterization of a novel gene, C13orf25, as a target for = 13q31-q32=20 amplification in malignant lymphoma. Cancer = Res.=20 64, 3087=963095 (2004).

        • Calin, G. A. et al. MicroRNA profiling=20 reveals distinct signatures in B cell chronic lymphocytic = leukemias.=20 Proc. Natl Acad. Sci. USA 101,=20 11755=9611760 (2004).

        • Tagawa, H. & Seto, M. A = microRNA cluster=20 as a target of genomic amplification in malignant lymphoma. = Leukemia 19, 2013=962016 = (2005).

        • Gordon, A. T. et al. A = novel and=20 consistent amplicon at 13q31 associated with alveolar = rhabdomyosarcoma.=20 Genes Chromosomes Cancer 28,=20 220=96226 (2000).

        • Schmidt, H. et al. Gains = of 13q are=20 correlated with a poor prognosis in liposarcoma. Mod.=20 Pathol. 18, 638=96644 (2005).

        • Hayashita, Y. et al. A = polycistronic=20 microRNA cluster, miR-17-92, is overexpressed in human lung = cancers and=20 enhances cell proliferation. Cancer = Res. 65, 9628=969632 (2005).

        • Trimarchi, J. M. & Lees, J. A. Sibling=20 rivalry in the E2F family. Nature Rev. Mol. = Cell=20 Biol. 3, 11=9620 (2002).

          • Article
            • <= /UL>

          • Lin, Y. W. et al. Loss of=20 heterozygosity at chromosome 13q in hepatocellular carcinoma: = identification=20 of three independent regions. Eur. J. = Cancer=20 35, 1730=961734 (1999).

          • Felli, N. et al. MicroRNAs = 221 and 222=20 inhibit normal erythropoiesis and erythroleukemic cell growth via kit = receptor=20 down-modulation. Proc. Natl Acad. Sci. = USA 102, 18081=9618086 (2005).

          • Nelson, P. T. et al. Microarray-based,=20 high-throughput gene expression profiling of microRNAs. Nature Methods 1, = 155=96161 (2004).

          • Thomson, J. M., Parker, J., Perou, C. M. & = Hammond, S. M.=20 A custom microarray platform for analysis of = microRNA gene=20 expression. Nature Methods 1, 47=9653 (2004).

          • Krichevsky, A. M., King, K. S., Donahue, C. P., = Khrapko, K.=20 & Kosik, K. S. A microRNA array reveals = extensive=20 regulation of microRNAs during brain development. RNA 9, 1274=961281 (2003).

          • Miska, E. A. et al. Microarray=20 analysis of microRNA expression in the developing mammalian = brain.=20 Genome Biol. 5, R68 = (2004).

          • Sempere, L. F. et al. Expression=20 profiling of mammalian microRNAs uncovers a subset of brain-expressed=20 microRNAs with possible roles in murine and human neuronal=20 differentiation. Genome Biol. 5, R13 (2004).

          • Smirnova, L. et al. Regulation of=20 miRNA expression during neural cell specification. Eur.=20 J. Neurosci. 21, 1469=961477 (2005).

          • Sun, Y. et al. Development = of a=20 micro-array to detect human and mouse microRNAs and characterization = of=20 expression in human organs. Nucleic Acids = Res.=20 32, e188 (2004).

          • Monticelli, S. et al. MicroRNA=20 profiling of the murine hematopoietic system. Genome=20 Biol. 6, R71 (2005).

          • Babak, T., Zhang, W., Morris, Q., Blencowe, B. J. = &=20 Hughes, T. R. Probing microRNAs with microarrays: = tissue=20 specificity and functional inference. RNA 10, 1813=961819 (2004).

          • Krutzfeldt, J. et al. Silencing of=20 microRNAs in vivo with 'antagomirs'. Nature 438, 685=96689 = (2005).

          • Izquierdo, M. Short interfering = RNAs as a=20 tool for cancer gene therapy. Cancer Gene = Ther.=20 12, 217=96227 (2005).

          • Gleave, M. E. & Monia, B. P. Antisense=20 therapy for cancer. Nature Rev. Cancer = 5, 468=96479 (2005).

          • He, H. et al. The role of = microRNA=20 genes in papillary thyroid carcinoma. Proc. = Natl Acad.=20 Sci. USA 102, 19075=9619080 (2005).

To= p of page

Author affiliations

  1. Yale University, Department of Molecular, Cellular &=20 Developmental Biology, 266 Whitney Avenue, New Haven, Connecticut = 06520,=20 USA.

Correspondence to: Frank J. Slack1=20 Email: frank.slack@yale.edu

To= p of page

MORE ARTICLES LIKE THIS

These links to content published by NPG are = automatically=20 generated.

NEWS AND VIEWS

Not miR-ly = a=20 splicing factor: hnRNP A1 succumbs to microRNA temptation

Nature Structural & Molecular Biology News = and Views=20 (01 Jul 2007)

Drosha = versus ADAR:=20 wrangling over pri-miRNA

Nature Structural & Molecular Biology News = and Views=20 (01 Jan 2006)

See all 5 matches for News And Views

RESEARCH

MicroRN= A genes=20 are transcribed by RNA polymerase II

The EMBO Journal Article (13 Oct = 2004)

See all 48 matches for Research

Extra navigation

Subscribe

Subscribe to Nature Reviews = Cancer

Search Pub Med for = the=20 following terms:

  • Aurora=20 Esquela-Kerscher
  • Frank=20 J. Slack

nature jobs

More science = jobs

nature products


Advertisement

To= p

Nature Reviews Cancer

ISSN: 1474-175X

EISSN: 1474-1768

------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://ad.doubleclick.net/ad/naturereviews.cancer/article;abr=!NN2;tile=1;type=rv;artid=nrc1840;date=200604;issue=4;subco=;chaco=;keywd=;njdis=;njreg=;crstg=;pos=top;sz=728x90;ptile=1;ord=123456789? R0lGODlh2AJaAPf/AP///z1cnlVwqrO/2drg7c/X5+ns9NDY6JCiyHWMusHL4F54r6y61mB6sM3V 5kZko9fd646gx4SYwr7J30Rjouvu9bTB2srS5HSLurzH3tjf7JKkyaa104KWwXuRvWqCtZ6uz8bQ 41l0rWJ8sd3j7n2Svqu41W2FtuXp8t/k72d/s113rkhmpLnE3IeawzVVmpurzThYnJWmymmBtEJg oeL0/VNvqU9rp1BtqFZxq3CIuG6Gt8zMzC5Ql9Bsbue2tvj8/rUqKP3+//D5/uT1/bgjJen3/vr9 //T7/vv+/+b1/e34/vb8/vnr6+f2/fL6/vPb29Z/gPLY2e/5/uv3/uzExfz29um7u/bi4jpanfrw 8MLM4dN2d/36+jZXmzBSmO/OzvTc3daAgeq/wP3+/tmKi/HT09yTlO7KyvTd3uOnqNTb6b0yNJ2t zsTO4jdYm/7+//fn596YmTJTmeCenvnu7vb3+zFTmcFAQoibxPr7/S9Rl7vG3cteX+awschfXuDl 8Ozv9vL0+PDz+K+81/j6/Pbk5NF6ef39/nKJuff4+zBRmO/x9+zDxPz8/eOvrvX3+sZPUe/y9+Hm 8HiOvMbP4tmIiezKyfT2+vry8tR7fP78/DVWmzNUmUdlpPj5+8PN4dqUk/v8/Tlanfn6/PT1+dXc 6j9eoPXg4NuRkrG+2MLM4Lo3NcNSUOLn8dzh7UpnpeGhov34+Pfl5WJ7sfHz+IuexbTA2bC92KOy 0UBfoKW00kNiooGVwHmOvOOqqsxta/HX1/P1+dTb6mR9somcxEFgoJyszpmqzExppubq896Zmvns 7L5FQ4yfxnmPvdPa6aCv0HOKuert9O3w9tLZ6cXO4oWZwui8vH6Tv+7x9vvz8/HV1e/Mzeays/jp 6ufr86Sz0meAtDtbnuPo8bfD28vU5daIhpeoy0topYqdxcjR5Obq8tje642gxlp1rd6hoXCHuJan y2uDtVhzrLrF3WV+ssnS5FFuqaGw0KKx0b3I3pSlyqe201t2rf///yH/C05FVFNDQVBFMi4wAwEC AAAh+QQFCgD/ACwAAAAA2AJaAAAI/wB5CBxIsKDBgwgTKlzIsKHDhxAjSpxIsaLFixgzatzIsaPH jyBDihxJsqRGAChTqlzJsqXLlzBjypxJs6bNmzhz6tzJs6fPn0CDCh1KtKjRo0iTKl3aUyDTp1Cj Sp1KtarVq1izat3KdavTrmDDih1LtqzZs2jTqm3KY63bt3Djyp1Lt67dol/v6t3Lt6/fv4ADz8wr uLDhw4gTK17MlrHjx5AjS558ljDly5gza97M2aXlzqBDix5NWu7n0qhTq17N+ujp1rBjy54N+zXt 27hz63Zse7fv38DDkiolrNKWLaAm5EOwIUI4BaC2KDA1CBMAahOOH58AwVFLUaYUaP/fsm8anALi jw9bSUZRKUboxx9fBYpAKUh6XuqxI+hVdvlbrGLOIKV8QsZKyrixinzWSOISOQoeV41MvQVn4YUY MrWBFz106OGHIHbICxmTvAFiABPAwVI9IeLwyiD4fPiBSoyoMgKHIYK4RzLXQCDKSnoUIAEOOYb4 xjyECKJSBEV2kB9LfATgYQMUtpXhlVhmWdQzLxTp5SKIkGFBlx8mM6FKptAAohflALAFLx8SgxIc r+TgpZdf7PIkAI4cc8edRTYASEoIFDlHLi1ZQ4GHC1Sp5aOQRmqTPV8AmiMiAJCSR4jEKJOSMsmA 2IkMKLmxqIdvoCTJPJYWuUiKKPH/0WqRGJCCki1ejrIGS6Z6SIOjkgYrrLAqVNrhHCLkoOyyy3rC CwWefILSICuEmA0kAGBCTIgYlFLqqR1mgdI9Oe7RyRzoppujNIMAQIYAOb6QLrqdLBKiLiEAIEoC d9owzUq9drgHsMMWbHCGMxjbAw3CBOLwww4P4sAWblhjHUqTsBAiArU4E6INBKQUcLgAFFLoh54k IEMbLLd8jC20KNxDOiRcJ6WHL6igTjQttyyDNMaAWAwAkOjwYSch+qKISqCAewfBB0ctdW4i2Nuh JzllcLOHe1ASYhYTqDRyD+LWIs2HvPABEyZeo1oAAJVk4eEcHmD6UgZkdqgDAHYk//LhMyZ++AKi KVXiNNRTJ674ajF8GEAGfEQu+eR8KPCvSoggY+kX0QAMLtkACNJ2h9eoCNMFc3zoBgD9cOKhLgfI NMOHGPDtt4ctoHPv2yiRcIOHT8dU4eLEF39Z3j3sMcobzDfv/BsB7HKgSoOcfWc2P4r9ubiif9iG TBqE6mElADCAYw+w2BETGRvQbvuHuCCyLYgrGKCqnR0GD9Pwxvfvv2Kum5WH3DE9lQRifiHawwfa 5bkPcW90PQCBTMhBiw+Rz3weuoFM2Oe+vn2IEABIQdA+tIdi2CoQ+OuB/l7Cv/+58IV+CaAAe4CA AqbEACIo0h78oQ1ebS90EPxeTP+UYQ8Llu98ONhg+zxUOw96iBAHGkCIRtECAKAQeIiDoRa32BcZ 9uALnniAGMdIxgdQAASmSwk45rEHL+3BAz50IBA/1DkAQGADzMGjPNYDAA38bnxH9BAshLE+GXTw dh2CIp9cECJPkMARKVyhZ6zExUpasi5/8pAxJgGITnryk51kxEpIgStAzUEdDfTQAz9EqtBdYxF3 iGUncjAJAFTjFB+yBgBMcD5P2A8mcJDAIT84vUAswFrViGQWL8nMZpplAQqjQE7C4cUejKMN5+tQ Jwj3LTl2z0PEqABKMNEB+k2CEFbrkAMAMIFReMgL3HSJHjzxIWm874kFNEfjBKf/gsMJj5LODKhA wSIOhZ3iFWtIqEIXmlBV7AolFshmh1ShB0Kk7kOnUFs3VQkARZQyfyogRAEgUIAFtNFXavJQACDQ x6314BTXWAUEGLoGU5igWh+6xj0TWUBEcCBEi0inJFvSwoEa9ahIKRbX3uCFpjr1qU3lhBCrMUKu RQNTiOjFST1kA2hslGQAYBEJX+CFN4ziol7SQSDcRaQPfYETTIXqG5DmQBDawXo8VYkgyumlobKk qEgNrGB9otQZLsIcAGBHCju0iF4oCSWimB2IaEEOAIwtACgxQANm6NY2oYQDyJshMUzHJA/hwoYA mMQ7vHSKZQ72tbDtSQJkNitz/0gCrx46wS9Twgh/WKsQ5oATo1JyAHpy9gUdeGymdiBRS+1BABpI SWk7ZAK7qWQduMwRLVwb2+56dya5wIEuxpGFLLzgC+hN7yLeQN4s0MATBeCAF8pb3lEsIAUtAYQn RkHfLIzCAhVYAH/LW7uUpOAEsDhFFryQ3gans0MLcMVKHGGCHNDAv3docINjkAVdsCABEk4JMug7 CgQUoiW4OMWA+zsP7n73xTBOySBQ4AALWEAVyHBBHna84w7sohwWGAA0XIGJfQzAxjY2QYhb4gpc INkChNgCNSqhCiRfgCWKCMEtolEMHu+4GNc45oc84CCWaGAADHCGjr2cBxdwwP8C5qgFS1Kgilvc uBreYUkhQuDkJ98iX/+MsaAHbZdAbPZDlBBlWgBL6EY7WisGqCCiy1wZgD760pgGCzjE7KEZ1LLS mQ41UvVgCmhgCybgMIANSYFQaBzAAIBgRxpVAolXeIcRJMCWHYaxNJbAgRw1q4UD5PySdvhCB4lI NjFAgVqxMFrU0C4eCbKhggbsYE8tQQcMeo0SdsxABLQQAAPQ0Q+XvIIY7TJHA1bHhw/sdiVtQIAe NrCAd7cEEZiwg74hUYpmh+XZ0Q741NqgiwlUIhfeeQUoygyIVSzNAyUAwEhR8oob8GMdE3jFLjIQ CA2EIHYA0MMFwnGKtVYAFgj/AMAOZlAIDVRCWpMoQAgmkQFCVIMGtOBDCuDACAjMei4AF7jQC7aB N+yiHSjZAj4+IA0DgGIB+DgBI64RAVUkA9B1QoY5XiEJX+xCAcm6ATIUkYAbsAAfawXANVQAARrc ggH+mAEGBoEACsAiAgOIAAh6cIN5dIAUEciDv+ES9KEbPlLksIUAYCGOSSTiBLvwhD46QAsLzCED 6lhAANqgvhCmAxYiyMYwRGCLWzwgAxKghTY6oYpjsCDtLcBBNt5hgBw8AxcBUEU2RHCPV8CAFsNI hzzccAoNUGAAPzeNpQ/P/MWhoB1ZgME7KKEPBGTAFwsgRDYKsKke1BEAr6DH/y4I4ApqiCACt1jA IEwgDm2MYhAaMEbahUEML/SCDLB4Rj6cUY9r9AIlbUALjCACAwAAAjACLEBpdVF4zdeAFwIDHqAA hMAJuxAPDZABx1ANHkAP9YAABnANJ4AMp2AKKEEAIrAK45QD7jAACzANu6AC2tADMFAMr5cSHqMK ACAC8bAF7qAMHZANKHEMDVABAmACAMAPe+AC2WMXDOiATugbCpAAvJADEfAJa5ADFHANg3AAKgAL OlALPAMJvrABKOEK2YBYROMBHAAKvcAILeAChSADLOAPvsBAABAC80CCEHACKcMIbQADKKEKHcAI HhA2a+AF67AXTfiEjHgbiP/wCcKACfkBB5AgCNICB4ogCHYAB3qQH4UgLe5SCHYDB4WgB45QCHBw ivpyH6iYEo84PZmoCJz4JKKAioXgCIrQC7SggAu4fI34i5h2ACegAIMXF4sIjMiYjEpxjMrYjM4I FMz4jNI4jTYRjdR4jdj4V76YjdzYjTdhjd4Yjs0IjuJYjr9IjuaYjg6IjurYjobHju4Yj9EGj/JY j5hGj/aYj4SGj/rYjy/Gj/4YkLAFkAJZkEhFkAaZkAEFj0hgBA75BC5hCIfwB39wCJewE0hABQ8p BC1xBEvgkEtwBFjxBA5pBBDZEkDwkUYwBUnQEpkADxT5B4+AFEIwBA5JBUj/sBNJoJJLAAQtIQQk 6ZA5iZIauZItyRJJMAU36ZMt0ZAbiZI8eZQrUZM3OZQskZEOOQQcaRZOaZJbuRIpCZJSqRJUaQQ4 aRZAWZUucQkTWZGGsBNBaZIuEZZGeRVleZZNWZRa6ZKhQJHAgA1IkZRLuRN0uQRjmRJ3aZXfuI09 IQROUAOQCZlO8JUo8QhBcJmYOZM3IQRGEJmQqQQiqRJI4JmQqZhR4ZikOZkrMQWkSQSmaQjNgJmX 2QqZUBRHQASkaQQ5MZqkeZKI+ZieqZoqsQStGZopcZukuQRTCZyRKZwpwZueaZrI6ZnKuRLE6ZlE YJxhgZrBSZkA8ASkWQPS/4mb1EkWR6AEuemdlimbQaCZNsGdzemdrImdpgkV0xmZummdxbkSwcAK 7HkIRnGfkFmdNwGdkTmeyZkT6NiZ4ZmfKGEI7ImZF2kT85maKgEE4QmZTCkVDJqbKsEEGUoEY9kK ERoE51AU6BmeU3ATSZChNcAEKtGhnkkFohmiXykE5EmainmdHpoSGJqhY5mipDkEKjEEGaoEZEEF GeqgAACiQIqYQuqZRCoWzOmZK5oSl1CiQfCWNiGj+PmhIXqYT1GlkXmlKGGk4akEX5kJ/hmhoUAU OJqhvkkTPxqeQZqhU1qNjKmTLloDxnkIWgoM79mnMIoSSpqhNCoVR9CnUv9JpmWKpVoaBLUpFE6a oTfBo6SZqACwqC4qlVHqmb4JnkeaEi3qosZ5qOFJoAaKnSqRozoqFqWaoafqoqrqokQgFpUanl8J DFoKoDXBqbKaEo4KmWYKFblKml/pqtGZEusZoaxAFKKapjeBqgmKEqsambe6mERxrKCaEn8QqTZR p+GZp58amUgqFdEanlbZpw4aCpE6oUGBphm6oTPhpZ6ZEulKmhvKrilhr5Hpo32ap/x6pn3KlOI6 pGJxsN2KEgMLAPIantq5FQ+rrykRqX9gE9d6oCnRsFAxsZ7JlMA6rilxDpEaDENBraR5Ew3rsZFJ r4OxpzqRsZDpm9+qpeH/GrApoazYOhX5uqwM66Lt+q5DwbIa2qV9mhJEWwP7CrT9erQoobCRKbBM S7AuarA4GxZQC5lSu6RIW7BhkbQbarE20bMa+7NcKxVg+7RXCwCAqqUmKxT+CpkqO7UO67V6ShQh S5p/qqUXWxOxqq4pgbKRqan22afGWa7EmhLYEKlcGhQyWwPeGROYGpwAa6opgbg1YKZEm60A8Lek WagAELea+riI2af1qRV5+7HCSqv46rRg8bhSSaIl6qs0kbqRebguWqxP8bhf2ae+CQ9a+qxDa6s3 IbrP2aeRG2hE4a9OoBJZWqLuSROTC5lE8JXcCpmgGxXDyqREO5axGaF9/ysUcZqqN5G1iom43Nup pOqieRq6o3q884qYOlsDBAoA01sD1TsW/nqu1lq18puhussV6KsSzcqe8EoTw9q8XfukUjG+1YoS FYqda9qm7HmiQ+G5UVug/osSDlye2oq3ypqdK+Gu/4kT8Em9ETu99RsVAoq/KQy4KtGf7Embtqms zlkTPbvCLSyiKyG4pnmtCkyqnyrCw6miK8EENkyZJ4y/2QsWSRDCL9ybRxyeN9wVLVzFbSubb3oT OxzFPjsVV6zEjmqaBTybkzoUQJwT06u7SJyayau8cLoEuEkEhtkS2FCzrRC97zkE6EnHYtqkwOkE TdzAcoy/S5C8SACcVP/gsg96CP7ZDKFwxkSxk7ipBHuZE0BwqE5wupRcA0pwyC3xBIrMyACQyZLZ vog5BX1cx1cJnEYwyJtKBZV8yWTJx/hLBRG7nUuwyn+cyJBJBbB8BLLsybQMq4Vsycn7CLL7lzoh BIVMx4g8ylfRycjMEjWZorjcEsHAq0EAyUhhyjXgBKiMsa4czMdczDWBkAq5zpakzuz8zjDkzvA8 z/1zGkwwBE/wxxyMBEOABG8sBPzszy8BBPicy6T6BEMAyxx8z0igz5s6BENg0CiRBPzMBG/cpPjs 0EeA0KS8z/180QT9BBLduQit0AAgBAyt0RA90hSd0Bd9z/n8Ehs9BB3/3bkVDdIFLdMc/RIo3c8O HdIsfdMu0dMNLdMQXdMtbdEvAdMjPdM1DdA+PdA57RJJUNI8ndI7QdQOPRNJ/dIZrdM0zdMBjdMi /RJVndBXHdUucQQrbdZC7RIwrdE7PdRjLdVlvdZz/ZNYPZdT3RJdPdR7vRKWAQRRSgWR+wSuOs6I LaUscZ6eaQTeKQQRTASDjASuGsBHUKVOkMuTXZ9tHJmgTJYyCpos8bBEMKco4dj4GdnUqgSMbNlW 2thVagRi2tks8dnEGtmjncumXZ+q/cus7ZmkvRKwncErkdmPHbmTPci4nbnWLKObXdr02diFHdzm msvFrbXUndxTudxX/3nZuwneOWHbR+yqhj2Vuy3d2DrOv10DkD2Vrf3a4q0SyI2ftT3d5W2lui3c vI2dqL2pUfreZNna2J3Yss3dq4mdzD3fKUEYtsuk34mnKkG27fvEVNzD8ZsS11usQlCuaqoSERyZ 2Qu1hAsAjsrDCyzFpKqzQYwS/qqdG06WOvvhKRHi2HuhGVq/S4y/Y8myitnC4bwS9krE/WvE/+vG RRye9Aq1On7ilGnj4knfOgvhJ66dGVvhLE6Z90uv17vCMhHjNwHl2Wu7JX7iPS6nKmHhFhqjwarh ACzjafrkGTriiLoSZl6kGfrjLC7k4UnkAJCxHJ7lSf65OE6+KkEYcf8Luh3smVu56JH5lfcb5Wp7 tiiBuVJJtHmKwZ/J5hn+56zLwfObvygR6VZ5ve7dquoLwex7nC7Kvya+wRGe4+tro4HrolYps4Q7 vzUglZHum7brySqBucZJtvQ7632uEoJbmvAbnprq6JDJ6y7qm1nb4sJuE5ZuE5oO7E3b6TJLoM4u 6vZr65XboMGe6gAA5TWQp7/u6sOqtK0r6xxsq1+Z7JLu6ZQOALoO7Wie2q1e7m2OEoTRpwSatS86 6XOes3SbtFv56+m+7ReOEsTup/Geuw7fmm4O632qqeheA+Menr7Z7g6atKGZ7Q3v4sRb5J2e8SkR 6Rxv8B5/uQnPqBP/vbZxy7+Pu7TwDgD03vKlbLoIT+lJe5QMP84yvbYzEfFMKQR9aqb0zrmm7u5m y+w17roE//Exb7mdS/Mnb+8p76KayvIdr+IAgLkhb7gzv+oNDlAre7VJu7XkbvIbTPBuH54pruQu 36Pu66J1j7BRj/dxK/E9j/YAsPZxr/V6T7VdT+l/H/aM3fePvfeqG/gSDveWivh27/hfSvl0f/eN P/hXn+FyXxOhXxNpK/lvn/eVX7eC37B/b7Wrv/WlP/qov/mqn/inv/icb9yeD/R2K/sAEPAUn/s3 bvqEjhK6rqkKz+/RXvGPD/Fmf9Jr2/QX3+nHP/WHT/wL++q8j/VK/y/4Nb/sl7/7hh7u10/wVkn2 kB+ZR0nyefr9KB/+Ar/yVO/zlf75uqr8kz8TDP/fMAEQT2oMJEjwCACEBRUOQQiAikKCRBoygUgQ SEMiFWtQaThFY42GRz4+aehEo5GGQz4eBCDkI0OERjRKRIjk48WEGpc0XPKxIZCPSBoqOZnyYxKE SV42BMCDB9OHFXG2zAiRiBCEQqoqvMpTo1CEQCuiHKoRKUKVFWECUFpRCVOZUhvarLgz69aCXRH2 rAgWgFiIZBESrXgWQFqIJJNqfNswLkSWAOhCtEu1Is29X39q5Fi2cEeNigGIrOiEqcmKkQVWnNKw rVWoGqdOVlgZAP/eiFgz9w1Z1DNEw0yFMyUMfPhx14zhyp6rs6HWy7oB8IXoF7BCwQCKKzSMeGFy t8tTN6/7HPdAzNM1h+VM3KzRiqJfK2yMEDVkpk6ZHjlvWzJv8hTyyzKFTGOKuogi+4s1poS4jyAn pAPAI4iY2K8/4R5ET0LaCBowifOyU48rBSmCaK2WNKwhQqYoVGiq0co7zSoJVxOQKRADEy6qvIIz 8bvnthvIQNAggvE6glqbkT4JvSPIQtfO68wxq4LrcCDRCCyIyN0UUhDJgZRE7jgwaxBzzOGcHAhK hPijLMMqmbqyhg9DFA5B9EpUq0EVWSzyxQvfXDKvGgFMys7YSGT/6seCUBRCyBWFc7EgGElT6Mym ntpvO0xr2oqIAT2NKNTRHqthCQkRmlQJBRFiojgiUMzKVCNSPWwrJdgMidPhhEDQiFYl+5TUIx5E dbhVg2XiU1lbotVW73Id7ghehROCxxqMCA6hJ4ad9sEpUhUi2eGWjSjLpEylAtqClIAxrO2avbYg bYfrNiJd2+RU3EmdCBaJT9FlS11byRXu1UbRHBNh9JpVOCVc8x2t2gZ//ddb4Y4w9VhJ21WW2V6f TbNdiaktqNN5CQJ2OIBH/fZkfj0uN+DhkhBZuGjf/Sve4fSbFgggthUOaCBs/Qloo9sEWujniEaT 6KTZAjrYpoF++XrpMZOYekwhnB7zCKyR0xoIqo8u+uuwj+va6jGhznpr5NbWeb+0a4YbObeRAzto rr3GG+m3ye6bbb3rFm7sssMCvHC+4/abzMUf/vtsyR0n/Li9mU7q7l7zxtxwHDkfzvOfG1f78dEj t1twy+cOCXTXRB9a9Yxhzwr12SkXzufKe/f9d+CDF3544os3/njkk1d+eeabd/556KOXfnrqq4+e d+uz13577rv3/nvwwxd/fPLLNx947M9Xf33223f/ffjjl39++J2y/37889d/f/779/9/AAZQgAMk YAENeEAEJlCBC2RgAx34QAhGUIITpGAFLXhBDDowIAAh+QQFCgD/ACwMAA4AxgEUAAAI/wD/CcSC ZsyPKma0CFzIsKHDhxAjSpxIsaJFhk1+jLnIUaDBHyA1glG4EIvGLg1NbnQo5YeZjhlX/jPYpKPN mzgdakEDEmXOn0AZ0gw680dNohZjLlTKsErIp1IWDg06FalVmxl/XG34tGuchWFAgmkYVqvDKz+u +EwKciHIo1vj3vz4Y63cu1yNEn2L92HWpW0XtryCxUqXJmaukPzHN2jjvpAFWgmDBS9IKVoyN3Gq VmDZH1/BBmYYJ2Rotmb/YQljJbJrh1kNv+67urVjvbP/CtTt8UeYhnYf/xQ+uzhSkL8Xamn8ubPn 0Qt5okXDkbdx49ava69IHDJv6yBPN/+04lRjlaM70Y4ZCXhMEzRXqlQmD3LM+YY8o0b/of9fGKdV JNcbXEwVhYUZY4xhhl29HTjGFWgo9N8PaFTWHmnwrUdSTO/FZ6F/AAooEHJ5JffZD2M9l5pAXSAH km0QaQFGgmCYlFpVcWSIRhh25XiFhgxNGOB+/f2TH4tSPIiGeBzCJ5+R/DF0ZJAfVVEFSgY5qKBP Vsy4HowGIgihhE5VKNGEFH7oV0EQ8igVblmKGWFKVUC4GXUj4oakkuI95COQe0LI5GjWlcmgQMuB hFZNWXW1YVcHdZFoWnoOlNZCVjTG01N4MqYnb5BWmiekm4bUH29mQNpaoyFdCSWnDJH/iGl4KrYE mopkXeqUiOOhBalbuNl6ha8vCZRqV7aVChKeJl0x6w8KdfGRrwKyCtKVzT4Ll0BS+NqTp13VpIW3 aS0WKoVdFcnQsVBBlNWwIBXr6VHnwnWir8DCJa2isj7Ebkit7Uupb4ClZl1p14IRxrbzMgSGGYZp UeZuy1phhRRrdfdPi7iFtVKzcXQRB1oWPgZqWk10sfBDiqbchK9gWAzGt//olhWPO1mYFRoWY6xa WiGP/MOHyHVh9E5p+VTWP5yhtHRTLvl3UESpXuEyvnnWxDF61Rads6VXBE3yxsxpZOxBrdlo2849 o7T1czJhBF3LKh9VpsU8VQGs1YfB/ywzzeONEXIXth7KNMH/aCFiY3S/TOFCaMU87miPpVpF2i/6 5bWZ/1iO+Q9rEwqdauRqZK6oDGVbc+YOafzPzMXylNyU/7SEp8mUIx5Rv2X59PbqZsGuOej4Rcnt 46NCetrSiY71NKJ8ZQotRE71Z2u+iV/6kPAO0W67QNzvKhBai8lOMfENcW8+bHPrLhnr0tvGO82/ S1R/rKhnnaeAYTmbPfrX09/4pieQ9aUvamchIJSS853R7QYLUtiUTFwHvPNBxHUZcRbHbIOW05TG f7hLDQUFWEHsldAgfbJgQzq4kA/u7SlVWIzUzGKrODyvdmYTSPUgwkKBIMyE6jGDFP8K86YU/qOH /3BhEi+1wez57zkpyg7FNMi6hoBHVBlkyKJIeEWGXTB/0gGDFMIgQ8Z9KjBZ9GHu0KM9KD4EhTpp o9SiKLoVDY9elfIRv8wiRRImsAkm0RsXAxNCE+7ujCtqjG40JsVC7u9szsGVDtMSwAH2p39fJNAa d0MXWWnMkUc0iknwZC1KCbKPoQTk1IaHP4Z1cZCJzB/hOpk/+jxFQGbUJB/raMJSokWQefGiL1fZ QDs+BC3JeUxZ0AAGMJRHha3L39nMwJMPIVGJoBxhw6C5Td3AkX3GvGYbZdUFtBTpeYnCGvC85Ssv esqDm1QOIGdGvG+u8FZqfGKqqDn/tPM1859i5Oa6XFJNd7XPlXLc4jZL6MeFcOafFNTCPFmXy4JN sYXxzApAm6mu3qRQoxvVTzEZYgWGSQ+PcMkSRndpzIbKzVdr8R7ykCkaEUrTkK8s4cxSZEUHyrRT /RrMWm5oq9HQM1Q8hZr14vnH16HoIT8tGM3iZ9CWrg6mVW3leFiXKPkhUqs9rQvkbqpF3FRUhV09 nk2PQlWK7NQhbQWnRSVjEDPEITNYMIhMDOKzohSrC5sS6Jv6+kaxpA5oIhsblNzTN6Zmcq4CtNnm GOhAkCW2n49kEVrkdcPDBaacvjGaaHvnkKopxArq5EsXqiAFw6gsczeT1I7AJjbM//bmqQ6lkBa6 cDF5obIouGWlIXPLMyvkDacHjSMBbeROM4zEaGXxKkohGzlJqdMgbjpchHgrBXmFFWez1e5ue1sw 2cTGbcoKiWIEE5Ka2OhXDG1IUd05wz6lt1OldCzLvtrL0fwLtg58VUg65SkR2YoknZ2UpdC3EI6p CXqhwt57nyKv/6LvvvKllXJKZzXB1tSI3OzO5NR7Ol2CtXh7RN2IKWxCUJ4oJOwl0YpbBhELt2bG KHvTt+jikyY4UyM7YlC3cPOnGlWBlDl8yJDpm0ayhKgh6VGQSt5EXypfyMqri1uRHxW3ID1ZKLbd mEFSNOVcrYQnBF7IzNKMqIKsp7TMRTmKjw0iqIZs2csH4dU/MtXlPSNIIxC7suaeqLm4VYWkXooZ mDVpaFkm6SAEuQ9c/1xnLFelQKop0w0Tg1kr/FlBYHLInSXz6UArZ1MoQZpYtyORfbL61bCOtWtc LetaR6Q0fba1rjGl0F37+tfAlkyvg70dlbWGPt4ltqw3BUxlO/vZs2E2tLVz1PqEetrauRu2t81t q2i7267pwrGusCBwF9tw5k63uh9itHW/Bt2+DggAIfkEBQoA/wAsDAAOAMYBFAAACP8A/wmsckaM jzJqsAhcyLChw4cQI0qcSLGiRYZSfIi5yFGgQR8gNdJRuLCKRisNTW506MeHmo4ZV/4zKKWjzZs4 HWI5AxJlzp9AGdIMOtNHTaIWYy5UyrBMyKd+Fg4NOhWpVZsZfVxt+LQrmIVXQNJpGFarQy4+uPhM CnIhyKNb49786GOt3LtcjRJ9i/dh1qVtF7bkUqWJFSlquJD8xzdo476QBTa5UgUvSD9YMktxqlZg WR9fwQZmCCZkaLZm/1W50iSya4dZDb/uu7q1Y72z/wrU7dHHlYZ2H/8UPrs4UpC/F2Jp/Lmz59EL eaI9w5G3cePWr2uvSBwyb+sgTzf/bOJUY5mjO9GKGQlYjJQzXMpUJg9SzPmGPKNG96H/3xWnZSTX G1xMFVWFGmKIoYZdvR0oBhdnKPSfD2dU1h5p8K1HUkzvxWehfwAKKBByeSX3mQ9jPZeaQFYgB5Jt EGFBR4J0mJRaVWBkeMYVduXIhYYMTRjgfv39kx+Lfjx4hngcwiefkfwxdGSQH5VRBkoGOaigT03M uB6MBiIIoYROVSjRhBR+6FdBEPIoFW5ZihlhSmVAuBl1I+KGpJLiPeQjkHtCyORo1pXJoEDLgYRW TVl1tWFXB1mRaFp6DpTWQk00xtNTeDKmJ2+QVponpJuG1B9vakDaWqMhXQklpwyR/4hpeCq2BJqK ZF3qlIjjoQWpW7jZyoWvLwmUale2lQoSniZxMasPClnxka8CsgrSlc0+C5dAfvjak6dd1YSFt2kt FiqFXRXJ0LFQQZTVsCAV6+lR58J1oq/AwiWtorI+xG5Ire1LqW+ApWZdadfSccW28zJEhxqGYVHm bss20YQfa3X3T4u4hbVSs2BYAQZaFj4GalpSWLHwQ4qmLIWvdFhMx7f/6JYVjztZmNUZFmOsWloh j+zDh8hZYfROaflU1j+cobR0Uy75d1BEqXLhMr551sQxetUWnbOlXARN8sbMaWTsQa3ZaNvOPaO0 9XMyYQRdyyofVabFPJUBrNWHwf8sM83jiRGyFbYeyjTB/2AhYmN0v0zhQmjFPO5oj6VaRtov+uW1 mf9YjrkPaxMKnWrkamSuqAxlW3PmDmn8z8zF8pTclP+0hKfJlCMeUb9l+fT26mbBrjno+EXJ7eOj Qnra0omO9TSifGUKLURO9Wdrvolf+pDwDtFuu0Dc7yoQWovJTjHxDXFvPmxz6y4Z69LbxjvNv0tU f6yoZ52ngGE5mz3619Pf+KYnkPWlL2pnISCUkvOd0e2mCn7YlExcB7zzQcR1GXEWx2yDltOUxn+4 Sw0FBVhB7JXQIH2yYEM6uJAP7u0pZViM1MxiKzA8r3ZmE0j1IMJCgSDMhOpRgx//CvOmFP6jh/9w YRIvtcHs+e85KcoOxTTIuoaAR1QZZMiiSHhFhl0wf9Khgx+uIEPGfSowWfRh7tCjPSg+BIU6aaPU oii6FQ2PXpXyEb/MIkUSJlAKJtEbFwMTQhPu7owraoxuNCbFQu7vbM7BlQ7TEsAB9qd/XyTQGndD F1lpzJFHNIpJ8GQtSgmyj6EE5NSGhz+GdXGQicwf4TqZP/o8RUBm1CQf62jCUqJFkHnxoi9X2UA7 PgQtyXlMWc5ABzqUR4Wty9/Z1MCTDyFRiaAcYcOguU3dwJF9xrxmG2VlBbQU6XmJwhrwvOUrL3rK g5tUDiBnRrxvrvBWanxiqqg5/7TzNfOfYuTmulxSTXe1z5Vy3OI2S+jHhXDmnxTEwjxZl8uCTbGF 8cwKQJuprt6kUKMb1U8xGdIEhkkPj3DJEkZ3acyGys1Xa/Ee8pApGhFK05CvLOHMUmRFB8q0U/0a zFpuaKvR0DNUPIWa9eL5x9eh6CE/LRjN4mfQlq4OplVt5XhYlyj5IVKrPa0L5G6qRdxUVIVdPZ5N j0JViuzUIW0Fp0UlYxA1gCEzVTCITAzis6IUywqbEuib+vpGsaQOaCIbG5Tc0zemZnKuArTZ5hjo QJAltp+PZBFa5HXDwwWmnL4xmmh755CqKaQJ6uSLFcrgB8OoLHM3k9SOwCY2zP/25qkOpRAWrHAx eaGyKLhlpSFzy7Mm5A2nB40jAW3kTjWMxGhl8SpKIRs5SanTIG46XIR46wd5hRVns9XubntbMNnE xm3KColiBBOSmtjoVwxtSFHdOcM+pbdTpXQsy77ay9H8C7YOfFVIOuUpEdmKJJ2dlKXQtxCOqQl6 ocLee58ir/+i777ypZVySmc1wdbUiNzszuTUezpdgrV4e0TdiClsQlCeKCTsJdGKWwYRC7dmxih7 07fo4hMpOFMjO2JQt3DzpxqVgZQ5fMiQ6ZtGsoSoIelRkEreRF8qX8jKq4tbkR8VtyA9WSi23ZhB UjTlXK2EJwReyMzSjKiCrKe0zEU5io8NIqiGbNnLB+HVPzLV5T0jSCMQu7Lmnqi5uFWFpF6KGZg1 aWhZJukgBLkPXP9cZyxXpUCqKdMNE4PZJvxZQWByyJ0l8+lAK2dTKEGaWLcjkX2y+tWwjrVrXC3r WkekNH22ta4xpdBd+/rXwJZMr4O9HZW1hj7eJbasNwVMZTv72bNhNrS1c9T6hHra2rkbtrfNbato u9uuscKxuLAgcBfbcOZOt7ofYrR1vwbdvg4IACH5BAXIAP8ALAwADgDGARQAAAj/AP8JVNMHT5FI mswIXMiwocOHECNKnEixokWGVYrguchRoMEiIDX6ULhQjUYtDU1udFimiKaOGVf+M1ilo82bOB2a 6QMSZc6fQBnSDDqzSE2iFmMuVMowUsinZRYODToVqVWbGYtcbfi064+FckD6aBhWq0M2Rdj4TApy IcijW+Pe/Fhkrdy7XI0SfYv3YdalbRe2ZKMGi5YqmtiQ/Mc3aOO+kAVikaMGL8gyZjJXcapWYNki X8EGZvgjZGi2Zv+pkYMlsmuHWQ2/7ru6tWO9s/8K1O2xiJyGdh//FD67OFKQvxeaafy5s+fRC3mi 7cORt3Hj1q9rr0gcMm/rIE83/8TiVGOkozvR4hkJGE+VPmwiVSYPEs/5hjyjRi+i/58cp5Ek1xtc TBWlhiZ44KGJXb0diAcbfSj0XxF9VNYeafCtR1JM78VnoX8ACigQcnkl91kRYz2XmkBaIAeSbRCZ 4UOCPpiUWlU/ZNiHHHblyIaGDE0Y4H79/ZMfi2U82Id4HMInn5H8MXRkkB9FEglKBjmooE9YzLge jAYiCKGETlUo0YQUfuhXQRDyKBVuWYoZYUqRQLgZdSPihqSS4j3kI5B7QsjkaNaVyaBAy4GEVk1Z dbVhVwdpkWhaeg6U1kJYNMbTU3gypidvkFaaJ6SbhtQfb5pA2lqjIV0JJacMkf+IaXgqtgSaimRd 6pSI46EFqVu42cqGry8JlGpXtpUKEp4msTFrEQpp8ZGvArIK0pXNPguXQGX42pOnXdVkhrdpLRYq hV0VydCxUEGU1bAgFevpUefCdaKvwMIlraKyPsRuSK3tS6lvgKVmXWnX+iDHtvMy5IMmhplR5m7L YoFFGWt190+LuIW1UrM/aPEDWhY+BmpaVWix8EOKplyFrz5Y7MO3/+iWFY87WZhVHxZjrFpaIY9c xIfIaWH0Tmn5VNY/nKG0dFMu+XdQRKmy4TK+edbEMXrVFp2zpWwETfLGzGlk7EGt2Wjbzj2jtPVz MmEEXcsqH1WmxTxFAqzVh8H/LDPN4+ERsha2Hso0wf+YIWJjdL9M4UJoxTzuaI+lGknaL/rltZn/ WI55EWsTCp1q5GpkrqgMZVtz5g5p/M/MxfKU3JT/tISnyZQjHlG/Zfn09upmwa456PhFye3jo0J6 2tKJjvU0onxlCi1ETvVna76JX/qQ8A7RbrtA3O8qEFqLyU4x8Q1xbz5sc+suGevS28Y7zb9LVH+s qGedp4BhOZs9+tfT3/imJ5D1pS9qZyEglJLzndHtRg1l2JRMXAe880HEdRlxFsdsg5bTlMZ/uEsN BQVYQeyV0CB9smBDOriQD+7tKZFYjNTMYqsfPK92ZhNI9SDCQoEgzITq0UQZ/wrzphT+o4f/cGES L7XB7PnvOSnKDsU0yLqGgEdUGWTIokh4RYZdMH/S8UEZ5CBDxn0qMFn0Ye7Qoz0oPgSFOmmj1KIo uhUNj16V8hG/zCJFEiawCibRGxcDE0IT7u6MK2qMbjQmxULu72zOwZUO0xLAAfanf18k0Bp3QxdZ acyRRzSKSfBkLUoJso+hBOTUhoc/hnVxkInMH+E6mT/6PEVAZtQkH+towlKiRZB58aIvV9lAOz4E Lcl5TFn64AMflEeFrcvf2TTBkw8hUYmgHGHDoLlN3cCRfca8ZhtlpQW0FOl5icIa8LzlKy96yoOb VA4gZ0a8b67wVmp8YqqoOf+08zXzn2Lk5rpcUk13tc+VctziNkvox4Vw5p8UNMM8WZfLgk2xhfHM CkCbqa7epFCjG9VPMRmCBYZJD49wyRJGd2nMhsrNV2vxHvKQKRoRStOQryzhzFJkRQfKtFP9Gsxa bmir0dAzVDyFmvXi+cfXoeghPy0YzeJn0JauDqZVbeV4WJco+SFSqz2tC+RuqkXcVFSFXT2eTY9C VYrs1CFtBadFJWMQTfwgM2owiEwM4rOiFEsLmxLom/r6RrGkDmgiGxuU3NM3pmZyrgK02eYY6ECQ Jbafj2QRWuR1w8MFppy+MZpoe+eQqikEC+rkixYiUQbDqCxzN5PUjsAmNsz/9uapDqWQGbRwMXmh sii4ZaUhc8szLOQNpweNIwFt5E5NjMRoZfEqSiEbOUmp0yBuOlyEeFsGeYUVZ7PV7m57WzDZxMZt ygqJYgQTkprY6FcMbUhR3TnDPqW3U6V0LMu+2svR/Au2DnxVSDrlKRHZiiSdnZSl0LcQjqkJeqHC 3nufIq//ou++8qWVckpnNcHW1Ijc7M7k1Hs6XYK1eHtE3YgpbEJQnigk7CXRilsGEQu3ZsYoe9O3 6OKTKjhTIztiULdw86caRYKUOXzIkOmbRrKEqCHpUZBK3kRfKl/IyquLW5EfFbcgPVkott2YQVI0 5VythCcEXsjM0oyogqyntMxFOYqPDSKohmzZywfh1T8y1eU9I0gjELuy5p6oubhVhaReihmYNWlo WSbpIAS5D1z/XGcsV6VAqinTDRODWSz8WUFgcsidJfPpQCtnUyhBmli3I5F9svrVsI61a1wt61pH pDR9trWuMaXQXfv618CWTK+DvR2VtYY+3iW2rDcFTGU7+9mzYTa0tXPU+oR62tq5G7a3zW2raLvb rtHCsdiwIHAX23DmTre6H2K0db8G3b4OCAAh+QQFCgD/ACwMAA4AxgEUAAAI/wD/CaxyRoyPMmqw CFzIsKHDhxAjSpxIsaJFhlJ8iLnIUaBBHyA10lG4sIpGKw1NbnTox4eajhlX/jMopaPNmzgdYjkD EmXOn0AZ0gw600dNohZjLlTKsEzIp34WDg06FalVmxl9XG34tCuYhVdA0mkYVqtDLj64+EwKciHI o1vj3vzoY63cu1yNEn2L92HWpW0XtuRSpYkVKWq4kPzHN2jjvpAFNrlSBS9IP1gyS3GqVmBZH1/B BmYIJmRotmb/VbnSJLJrh1kNv+67urVjvbP/CtTt0ceVhnYf/xQ+uzhSkL8XYmn8ubPn0Qt5oj3D kbdx49ava69IHDJv6yBPN/9s4lRjmaM70YoZCViMlDNcylQmD1LM+YY8o0b3of/fFadlJNcbXEwV VYUaYoihhl29HSgGF2co9J8PZ1TWHmnwrUdSTO/FZ6F/AAooEHJ5JfeZD2M9l5pAViAHkm0QYUFH gnSYlFpVYGR4xhV25ciFhgxNGOB+/f2TH4t+PHiGeBzCJ5+R/DF0ZJAflVEGSgY5qKBPTcy4HowG IgihhE5VKNGEFH7oV0EQ8igVblmKGWFKZUC4GXUj4oakkuI95COQe0LI5GjWlcmgQMuBhFZNWXW1 YVcHWZFoWnoOlNZCTTTG01N4MqYnb5BWmiekm4bUH29qQNpaoyFdCSWnDJH/iGl4KrYEmopkXeqU iOOhBalbuNnKha8vCZRqV7aVChKeJnExqw8KWfGRrwKyCtKVzT4Ll0B++NqTp13VhIW3aS0WKoVd FcnQsVBBlNWwIBXr6VHnwnWir8DCJa2isj7Ebkit7Uupb4ClZl1p19JxxbbzMkSHGoZhUeZuyzbR hB9rdfdPi7iFtVKzYFgBBloWPgZqWlJYsfBDiqYsha90WEzHt//olhWPO1mY1RkWY6xaWiGP7MOH yFlh9E5p+VTWP5yhtHRTLvl3UESpcuEyvnnWxDF61Rads6VcBE3yxsxpZOxBrdlo2849o7T1czJh BF3LKh9VpsU8lQGs1YfB/ywzzeOJEbIVth7KNMH/YCFiY3S/TOFCaMU87miPpVpG2i/65bWZ/1iO uQ9rEwqdauRqZK6oDGVbc+YOafzPzMXylNyU/7SEp8mUIx5Rv2X59PbqZsGuOej4Rcnt46NCetrS iY71NKJ8ZQotRE71Z2u+iV/6kPAO0W67QNzvKhBai8lOMfENcW8+bHPrLhnr0tvGO82/S1R/rKhn naeAYTmbPfrX09/4pieQ9aUvamchIJSS853R7aYKftiUTFwHvPNBxHUZcRbHbIOW05TGf7hLDQUF WEHsldAgfbJgQzq4kA/u7SllWIzUzGIrMDyvdmYTSPUgwkKBIMyE6lGDH/8K86YU/qOH/3BhEi+1 wez57zkpyg7FNMi6hoBHVBlkyKJIeEWGXTB/0qGDH64gQ8Z9KjBZ9GHu0KM9KD4EhTppo9SiKLoV DY9elfIRv8wiRRImUAom0RsXAxNCE+7ujCtqjG40JsVC7u9szsGVDtMSwAH2p39fJNAad0MXWWnM kUc0iknwZC1KCbKPoQTk1IaHP4Z1cZCJzB/hOpk/+jxFQGbUJB/raMJSokWQefGiL1fZQDs+BC3J eUxZzkAHOpRHha3L39nUwJMPIVGJoBxhw6C5Td3AkX3GvGYbZWUFtBTpeYnCGvC85SsvesqDm1QO IGdGvG+u8FZqfGKqqDn/tPM1859i5Oa6XFJNd7XPlXLc4jZL6MeFcOafFMTCPFmXy4JNsYXxzApA m6mu3qRQoxvVTzEZ0gSGSQ+PcMkSRndpzIbKzVdr8R7ykCkaEUrTkK8s4cxSZEUHyrRT/RrMWm5o q9HQM1Q8hZr14vnH16HoIT8tGM3iZ9CWrg6mVW3leFiXKPkhUqs9rQvkbqpF3FRUhV09nk2PQlWK 7NQhbQWnRSVjEDWAITNVMIhMDOKzohTLCpsS6Jv6+kaxpA5oIhsblNzTN6Zmcq4CtNnmGOhAkCW2 n49kEVrkdcPDBaacvjGaaHvnkKoppAnq5IsVyuAHw6gsczeT1I7AJjbM//bmqQ6lEBascDF5obIo uGWlIXPLsybkDacHjSMBbeRONYzEaGXxKkohGzlJqdMgbjpchHjrB3mFFWez1e5ue1sw2cTGbcoK iWIEE5Ka2OhXDG1IUd05wz6lt1OldCzLvtrL0fwLtg58VUg65SkR2YoknZ2UpdC3EI6pCXqhwt57 nyKv/6LvvvKllXJKZzXB1tSI3OzO5NR7Ol2CtXh7RN2IKWxCUJ4oJOwl0YpbBhELt2bGKHvTt+ji Eyk4UyM7YlC3cPOnGpWBlDl8yJDpm0ayhKgh6VGQSt5EXypfyMqri1uRHxW3ID1ZKLbdmEFSNOVc rYQnBF7IzNKMqIKsp7TMRTmKjw0iqIZs2csH4dU/MtXlPSNIIxC7suaeqLm4VYWkXooZmDVpaFkm 6SAEuQ9c/1xnLFelQKop0w0Tg9km/FlBYHLInSXz6UArZ1MoQZpYtyORfbL61bCOtWtcLetaR6Q0 fba1rjGl0F37+tfAlkyvg70dlbWGPt4ltqw3BUxlO/vZs2E2tLVz1PqEetrauRu2t81tq2i7266x wrG4sCBwF9tw5k63uh9itHW/Bt2+DggAIfkEBQoA/wAsDAAOAMYBFAAACP8A/wnEgmbMjypmtAhc yLChw4cQI0qcSLGiRYZNfoy5yFGgwR8gNYJRuBCLxi4NTW50KOWHmY4ZV/4z2KSjzZs4HWpBAxJl zp9AGdIMOvNHTaIWYy5UyrBKyKdSFg4NOhWpVZsZf1xt+LRrnIVhQIJpGFarwys/rvhMCnIhyKNb 4978+GOt3LtcjRJ9i/dh1qVtF7a8gsVKlyZmrpD8xzdo476QBVoJgwUvSClaMjdxqlZg2R9fwQZm GCdkaLZm/2EJYyWya4dZDb/uu7q1Y72z/wrU7fFHmIZ2H/8UPrs4UpC/F2pp/Lmz59ELeaJFw5G3 cePWr2uvSBwyb+sgTzf/tOJUY5WjO9GOGQl4TBM0V6pUJg9yzPmGPKNG/6H/XxinVSTXG1xMFYWF GWOMYYZdvR04xhVoKPTfD2hU1h5p8K1HUkzvxWehfwAKKBByeSX32Q9jPZeaQF0gB5JtEGkBRoJg mJRaVXFkiEYYduV4hYYMTRjgfv39kx+LUjyIhngcwiefkfwxdGSQH1VRBUoGOaigT1bMuB6MBiII oYROVSjRhBR+6FdBEPIoFW5ZihlhSlVAuBl1I+KGpJLiPeQjkHtCyORo1pXJoEDLgYRWTVl1tWFX B3WRaFp6DpTWQlY0xtNTeDKmJ2+QVponpJuG1B9vZkDaWqMhXQklpwyR/4hpeCq2BJqKZF3qlIjj oQWpW7jZeoWvLwmUale2lQoSniZdMesPCnXxka8CsgrSlc0+C5dAUvjak6dd1aSFt2ktFiqFXRXJ 0LFQQZTVsCAV6+lR58J1oq/AwiWtorI+xG5Ire1LqW+ApWZdadeCEca28zIEhhmGaVHmbstaYYUU a3X3T4u4hbVSs3F0EQdaFj4GalpNdLHwQ4qm3ISvYFgMxrf/6JYVjztZmBUaFmOsWlohj/zDh8h1 YfROaflU1j+cobR0Uy75d1BEqV7hMr551sQxetUWnbOlVwRN8sbMaWTsQa3ZaNvOPaO09XMyYQRd yyofVabFPFUBrNWHwf8sM83jjRFyF7YeyjTB/2ghYmN0v0zhQmjFPO5oj6VaRdov+uW1mf9YjvkP axMKnWrkamSuqAxlW3PmDmn8z8zF8pTclP+0hKfJlCMeUb9l+fT26mbBrjno+EXJ7eOjQnra0omO 9TSifGUKLURO9Wdrvolf+pDwDtFuu0Dc7yoQWovJTjHxDXFvPmxz6y4Z69LbxjvNv0tUf6yoZ52n gGE5mz3619Pf+KYnkPWlL2pnISCUkvOd0e0GC1LYlExcB7zzQcR1GXEWx2yDltOUxn+4Sw0FBVhB 7JXQIH2yYEM6uJAP7u0pVViM1Mxiqzg8r3ZmE0j1IMJCgSDMhOoxgxT/CvOmFP6jh/9wYRIvtcHs +e85KcoOxTTIuoaAR1QZZMiiSHhFhl0wf9IBgxTCIEPGfSowWfRh7tCjPSg+BIU6aaPUoii6FQ2P XpXyEb/MIkUSJrAJJtEbFwMTQhPu7owraoxuNCbFQu7vbM7BlQ7TEsAB9qd/XyTQGndDF1lpzJFH NIpJ8GQtSgmyj6EE5NSGhz+GdXGQicwf4TqZP/o8RUBm1CQf62jCUqJFkHnxoi9X2UA7PgQtyXlM WdAABjCUR4Wty9/ZzMCTDyFRiaAcYcOguU3dwJF9xrxmG2XVBbQU6XmJwhrwvOUrL3rKg5tUDiBn RrxvrvBWanxiqqg5/7TzNfOfYuTmulxSTXe1z5Vy3OI2S+jHhXDmnxTUwjxZl8uCTbGF8cwKQJup rt6kUKMb1U8xGWIFhkkPj3DJEkZ3acyGys1Xa/Ee8pApGhFK05CvLOHMUmRFB8q0U/0azFpuaKvR 0DNUPIWa9eL5x9eh6CE/LRjN4mfQlq4OplVt5XhYlyj5IVKrPa0L5G6qRdxUVIVdPZ5Nj0JViuzU IW0Fp0UlYxAzxCEzWDCITAzis6IUqwubEuib+vpGsaQOaCIbG5Tc0zemZnKuArTZ5hjoQJAltp+P ZBFa5HXDwwWmnL4xmmh755CqKcQK6uRLF6ogBcOoLHM3k9SOwCY2zP/25qkOpZAWunAxeaGyKLhl pSFzyzMr5A2nB40jAW3kTjOMxGhl8SpKIRs5SanTIG46XIR4KwV5hRVns9XubntbMNnExm3KColi BBOSmtjoVwxtSFHdOcM+pbdTpXQsy77ay9H8C7YOfFVIOuUpEdmKJJ2dlKXQtxCOqQl6ocLee58i r/+i777ypZVySmc1wdbUiNzszuTUezpdgrV4e0TdiClsQlCeKCTsJdGKWwYRC7dmxih707fo4pMm OFMjO2JQt3DzpxpVgZQ5fMiQ6ZtGsoSoIelRkEreRF8qX8jKq4tbkR8VtyA9WSi23ZhBUjTlXK2E JwReyMzSjKiCrKe0zEU5io8NIqiGbNnLB+HVPzLV5T0jSCMQu7Lmnqi5uFWFpF6KGZg1aWhZJukg BLkPXP9cZyxXpUCqKdMNE4NZK/xZQWByyJ0l8+lAK2dTKEGaWLcjkX2y+tWwjrVrXC3rWkekNH22 ta4xpdBd+/rXwJZMr4O9HZW1hj7eJbasNwVMZTv72bNhNrS1c9T6hHra2rkbtrfNbatou9uu6cKx rrAgcBfbcOZOt7ofYrR1vwbdvg4IACH5BAUKAP8ALAwADgDGARQAAAibAAEIHEiwoMGDCBMqXMiw ocOHECNKnEixosWLGDNq3Mixo8ePIEOKHEmypMmTKFOqXMmypcuXMGPKnEmzps2bOHPq3Mmzp8+f QIMKHUq0qNGjSJMqXcq0qdOnUKNKnUq1qtWrWLNq3cq1q9evYMOKHUu2rNmzaNOqXcu2rdu3cOPK nUu3rt27ePPq3cu3r9+/gAMLHky4sOGRAQEAIfkEBQoA/wAsDQAOAD8BFAAACP8Ax/zA8q+gQYMC wxz8h+XHmIUFpfwwA7FiwSYOLWrcyHGjwCYdQ2J8GLLkQoE/UjoEo+VgwzFdFr6sKJEiR5Qqx5ix AhELmitj0MQ5qTLlGJYmkypdajGlwqY/rvA0GCZlxStRY4q0yrQrVJBeDWL8EZZj0bNDC1b9AWbh 2qtZzZ5NeQVsQTRz2xqcqzJt2ZIj/1Z0qlElmoNvF8bpC5irYK8p7Ya1EobgY4gppWjZ3KRK3H9r f/gF7djg4pSjB//QvDmOQJL/wGTW0sRM5r2rN9P2fEXrZY1jf+N+qho11dJ3o/44vJWs8KWRn0sn bFBLdNJ0fSc+iBcr88I/iP//s/4DpBXqBW33Loh+/HXpC4M/b7+w6HrsC7s4TTmV49g4nlVhWUFa /LRSSy7hFVRqPv1QhRS+FYSFZ0K9d9BIAF6BRkthUDjgP4GZ9tNRCI7UxE8CGmQFGGMc1d8/9FEX GlvHOWeQfuHxt1GM4YGoo4pggDEVj+IdFMeIaIQRE15ScLcagSw6CEZaYaBUxXddSDGGhqNhWIWG HHrIXo9QSYGVTdupFdU/nhVp0VhnPQVnUQj+I5Fy79mGZxWI8SWZWHzhVVSTFzmmZ1E8zZlSFTFp gZVKV9TZ3nmiqbmacfj1eQWbZEIlHo5DVbXpjp3+Q2lqEdH1KEUNjWpqdIpG/2dmTgV1gdKjxMW6 3FlN0neQU2txiJxnFFXFZ0djoWGFFd0ZBMZOXWhBYa3XxWHXWOYlZJB3ywr6Z6FsWaEFSkKumJJW 8o2lZIGWJbsshAVR2K2Dw3Vhb4GfvcVbTGlyWiy94BHXhWzr9YtZePZG212E1JZH4FM4glUVSZ4R 2gUW15ZmWxU8NfTDVGMJOW5K5cr2A45uDscpn2mSZ15KdQL3I6UxG9QqgWtWZBuh/yxGEnkIUvqt jydLeG7DYMknm03x/ajizD/yhSl+5LXVcnQ0g/doUU8ZXJ/UqLrn6kJLJ/eUhReWhlWdeMl5NENv R+yryuSFkaZEsFXsLK+Fjv+N1dDy/YNVFWZIgYVvnvlFaUwY+e0wRIEHDuPj8gkUtuR9H/T3mFs7 GHNid8Zxd0bxPgnVWWMM6PWveC5as+YOFY5Ff43/g+NU3aEhRRhx+Ba4dWNXpVfkpUU295hPqXcn 7DyLuveg4LIO1pGPPipW55FyPldLkqMd/fdjJs2V90RDXvzj1KkX4Xa8Lb+t6aSN/TVrWrwYv1zJ f1ZREzih93dDxzKVZ+xTIsfEanDg6155jjc5iPUPUK17lF0SZi9AOQ4ka0FDkAYYH9FNS3BSCpII E5WzgmzOfDZSoPicY7n9IcdHF0RerbDCs0y5B08Q3JoEPSWzjx1kRUKSoe3/aMgR2mDBZFOxjRnw 8iFTNQELVVpOAkkmwiARing2mpy6AmaaojyPL3rp4VSyJpABncYiZ/xH2yxCnjGSD4vS+55swpi2 LBaEUlNpoxDtpL/RqeSLeeGhRSglHvXtUSL36cgJG/e2iqQxcHh8kwHPNxb66UYr7RGUc7qAFSVR cC0Ma9py5jUqgdikC4Kq1YOs0AVmSRFuV+hdF47UH6yAwV4mA9wks3iddDlFYW6zY+mU5coAooeT E6nRQga4yU5SsAugVE3KnqeZ2txmj8hk2kG6sEp7raU/5DqIGcDQhHvhhTlj0YJWKKROK0iBaXDE ja6uOSnrwc2H20xJE0UZ/Cej8cWfZ7GLJlXCtDsF1IUppCT4DqUSEgpzPNiTVKnuhKB+kcc5HrMf jvbZQI4MlGSsEw9Fe8IXba7FL46aS10Q8keInmWl5QOfFvsHvX+U0S2kO2dFZPMdF6YuQB+i3lEm 9J0mRIlEbsldajrkINc8rmmwCVFBPlIo2PRsREjxkVV/yCIXHeSmNxKIXmaCU5LoFCI8rQhYN+IT oAiFKB+yFY0gFyUuNU1+VjADSnTyIlfCJq+v2Qmgokq6qT4VPohNrGIXy9jGLkWJjo2sZCdL2cpa 1itWOOFlN8vZznr2s14RVABBS9rSmva0k5UXalfL2ta6tisVBG1AAAAh+QQFCgD/ACwNAA4APwEU AAAI/wDF+Kjyr6BBgwKvHPxXxYeYhQX9+FADsWJBKQ4tatzIcaNAKR1DYnwYsuRCgT5SOqSD5WBD MVYWvqwokSJHlCrFqGkCscoZLmLOgDmpMqUYliaTKl1qMaXCpj648DR4JWVFLlFjirTKtCtUkF4N YvQRlmPRs0MLVvVBZ+Haq1nNnk3JBWzBM3PbGpyrMm3ZkiP/VnSqUeWZg28XgukLmKtgrynthm1y heBjiCn9YNkspUzcf2t9+AXt2ODilKMH+9C8GYxAkv/oZMYiRU3mvas30/bMRetljWN/436qGjXV 0nej+ji8lazwpZGfSydsEEt00nR9Jz6IFyvzwj6I//+z7gNkE+oFbfcuiH78dekLgz9vv7DoeuwL rThNOZXjWDCelWFZQVj8tFJLLuEVVGo++VCGH74VVIVnQr130EgAcnFGS1dQOOA/gZn201EIjiTF TwIa1AQdYhzV3z/0URcaW8c5Z5B+4fG3UYzhgaijinTQMRWP4h0ExohnXBETXn5wtxqBLDpIR1pX oFTGd1b4IYaGo2FYhoYceshej1D5gZVN26kV1T+eFWnRWGc9BWdRCP4jkXLv2YZnGYjxJZlYfOFV VJMXOaZnUTzNmVIZMWGBlUpc1NneeaKpuZpx+PXJBZtkQiUejkNVtemOnf5DaWoR0fUoRQ2Namp0 ikb/Z2ZOBVmB0qPExbrcWU3Sd5BTa3GInGcUVcVnR2Od0UQT3RlEx05WYEFhrdeBYddY5iVkkHfL CvpnoWw1gQVKQq6YklbyjaVkgZYluyyEBVHYrYPDWWFvgZ+9xVtMaXJaLL3gEWeFbOv1i1l49kbb XYTUlkfgUziCVRVJnhFqRRXXlmZbGTw15MNUYwk5bkrlyuYDjm4OxymfaZJnXkp1AvcjpTEb1CqB a1ZkG6H/LEYSeQhS+q2PJ0t4bsNgySebTfH9qOLMP/KFKX7ktdVydDSD92hRTxlcn9SouufqQksn 95SFF5aGVZ14yXk0Q29H7KvK5F2RpkSwVewsr4WO/43V0PL9g1UZavhRhW+e+UVpTBj57TBEgQcO 4+PyCRS25H0f9PeYWzsYc2J3gnF3RvE+CdVZYgzo9a94Llqz5g4VXkV/jf+D41TdneHHFWD4Frh1 Y1elV+SlRTb3mE+pdyfsPIu696Dgsg7WkY8+KlbnkXI+V0uSox3992MmzZX3RENe/OPUqRfhdrwt v63ppI39NWtYvBi/XMl/VpEUOKH3d0PHMpVn7FMix8RqcODrXnmONzmI9Q9QrXuUXRJmL0A5DiRr OUOQBhgf0U1LcFIKkggTlbOCbM58NlKg+Jxjuf0hx0cXRF6tsMKzTLkHTxDcmgQ9JbOPHWRFQpKh 7f9oyBHaVMFkU7GNGvDyIVNJoQpVWk4CSSbCIBGKeDaanLoCZpqiPI8veunhVLImkAGdxiJn/Efb LEKeMZIPi9L7nmzCmLYsFoRSU2mjEO2kv9Gp5It54aFFKCUe9e1RIvfpyAkb97aKpDFweHyTAc83 FvrpRivtEZRzrIAVJVFwLQxr2nLmNSqB2MQKgqrVg5pgBWZJEW5c6J0VjtQfrNDBXiYD3CSzeJ10 OUVhbrNj6ZTlygCih5MTqdFCBrjJTlLQCqBUTcqep5na3GaPyGTaQaywSnutpT/kOoga6CCFe+GF OWPBglYopM4m+IFpcMSNrq45KevBzYfbTEkTRRn8J6PxxZ9nsYsmVcK0OwXUhSmkJPgOpRISCnM8 2JNUqe6EoH6Rxzkesx+O9tlAjgyUZKwTD0V7whdtrsUvjppLXRDyR4ieZaXlA58W+we9f5TRLaQ7 Z0Vk8x0Xpi5AH6LeUSb0HSlEiURuyV1qOuQg1zyuabAJUUE+UijY9GxESPGRVX/IIhcd5KY3Eohe ZoJTkugUIjytCFg34hOgCIUoH7IVjSAXJS41TX5NUANKdPIiV8Imr6/ZCaCiSrqpPhU+iE2sYhfL 2MYuRYmOjaxkJ0vZylrWK0044WU3y9nOevazXhFUAEFL2tKa9rSTlRdqV8va1rq2KxUEbUAAACH5 BAXIAP8ALA0ADgA/ARQAAAj/APEUUfOvoEGDAuUc/KemCJ6FBcsU0QSxYsEqDi1q3Mhxo8AqHUNi fBiy5EKBRVI69GHmYEM8Wha+rCiRIkeUKvFowgJRTR82ePr8OKkyJR6WJpMqXWoxpcKmRdjwNCgn ZUU2UWOKtMq0K1SQXg1iLBKWY9GzQwtWLeJj4dqrWc2eTckGbME+c9sanKsybdmSI/9WdKpRZZ+D bxf+6AuYq2CvKe2GxSKH4GOIKcuY2VwlUtx/a4v4Be3Y4OKUowcX0bz5h0CS/3xkNlNFU+a9qzfT 9sxG62WNY3/jfqoaNdXSd6MWObyVrPClkZ9LJ2zQTHTSdH0nPogXK/PCRYj//7NeBCQW6gVt9y6I fvx16QuDP2+/sOh67Au1OE05lePYH55FYllBZvy0Uksu4RVUaj4VEUkZvhWkhmdCvXfQSACy0UdL clA44D+BmfbTUQiOVMVPAhqEhQ94HNXfP/RRFxpbxzlnkH7h8bdRjOGBqKOKPvgwFY/iHfTDiH3I ERNeZXC3GoEsOuhDWnKgFMl3WpSBh4ajYRiJhhx6yF6PUJWBlU3bqRXVP54VadFYZz0FZ1EI/iOR cu/ZhmckiPElmVh84VVUkxc5pmdRPM2ZUiQxmYGVSmzU2d55oqm5mnH49ckGm2RCJR6OQ1W16Y6d /kNpahHR9ShFDY1qanSKRv9nZk4FaYHSo8TFutxZTdJ3kFNrcYicZxRVxWdHY/WBBRbdGeTDTlqY QWGt1/1g11jmJWSQd8sK+mehbGFhBkpCrpiSVvKNpWSBliW7LIQFUditg8NpYW+Bn73FW0xpclos veARp4Vs6/WLWXj2RttdhNSWR+BTOIJVFUmeEaqFGteWZlskPDVUxFRjCTluSuXKVgSObg7HKZ9p kmdeSnUC9yOlMRvUKoFrVmQbof8sRhJ5CFL6rY8nS3huw2DJJ5tN8f2o4sw/8oUpfuS11XJ0NIP3 aFFPGVyf1Ki65+pCSyf3lIUXloZVnXjJeTRDb0fsq8rkyZGmRLBV7CyvhY7/jdXQ8v2DVSSalKGG b575RWlMGPntMESBBw7j4/IJFLbkfR/095hbOxhzYnf+cHdG8T4J1Vl4DOj1r3guWrPmDhWuRn+N /4PjVN31UYYcP/gWuHVjV6VX5KVFNveYT6l3J+w8i7r3oOCyDtaRjz4qVueRcj5XS5KjHf33YybN lfdEQ17849SpF+F2vC2/remkjf01a2a8GL9cyX9WURU4ofd3Q8cylWfsUyLHxGpw4OteeY43OYj1 D1Cte5RdEmYvQDkOJGvpQ5AGGB/RTUtwUgqSCBOVs4Jsznw2UqD4nGO5/SHHRxdEXq2wwrNMuQdP ENyaBD0ls48dZEVCkqHt/2jIEdqowWRTsY0m8PIhU1VBDVVaTgJJJsIgEYp4NpqcugJmmqI8jy96 6eFUsiaQAZ3GImf8R9ssQp4xkg+L0vuebMKYtiwWhFJTaaMQ7aS/0anki3nhoUUoJR717VEi9+nI CRv3toqkMXB4fJMBzzcW+ulGK+0RlHO0gBUlUXAtDGvacuY1KoHYRAuCqtWDsKAFZkkRbmzonRaO 1B+s+MBeJgPcJLN4nXQ5RWFus2PplOXKAKKHkxOp0UIGuMlOUlALoFRNyp6nmdrcZo/IZNpBtLBK e62lP+Q6iCZ8UIV74YU5YzGDViikTiyUgWlwxI2urjkp68HNh9tMSRNFGfwno/HFn2exiyZVwrQ7 BdSFKaQk+A6lEhIKczzYk1Sp7oSgfpHHOR6zH4722UCODJRkrBMPRXvCF22uxS+OmktdEPJHiJ5l peUDnxb7B71/lNEtpDtnRWTzHRemLkAfot5RJvSdKkSJRG7JXWo65CDXPK5psAlRQT5SKNj0bERI 8ZFVf8giFx3kpjcSiF5mglOS6BQiPK0IWDfiE6AIhSgfshWNIBclLjVNfljQBEp08iJXwiavr9kJ oKJKuqk+FT6ITaxiF8vYxi5FiY6NrGQnS9nKWtYrWDjhZTfL2c569rNeEVQAQUva0pr2tJOVF2pX y9rWurYrFQRtQAAAIfkEBQoA/wAsDQAOAD8BFAAACP8AU0Xp9q+gQYMCGx381y1KqoUFr0TxBrFi wTQOLWrcyHGjwDQdQ2J8GLLkQoFRUjr8Netgw1RWFr6sKJEiR5QqU3mrA7FbLEupYnE7qTJlKpYm kypdajGlwqZRLPE02ChlRUtRY4q0yrQrVJBeDWKMEpZj0bNDC1aN8mvh2qtZzZ5NaQlswVhz2xqc qzJt2ZIj/1Z0qlFlrINvF3LrC5irYK8p7Yat04jgY4gpr8zanGZZ3H9ro/gF7djg4pSjB0fRvJmb QJL/fmWelcZb5r2rN9P2bEnrZY1jf+N+qho11dJ3o0Y5vJWs8KWRn0snbHBWdNJ0fSc+iBcr88JR iP//sx4FZB3qBW33Loh+/HXpC4M/b7+w6HrsC604TTmV41huni1jWUGz/LRSSy7hFVRqPkWxzBW+ FdSNZ0K9d9BIAFoSS0uNUDjgP4GZ9tNRCI6Uxk8CGlTHL6kc1d8/9FEXGlvHOWeQfuHxt1GM4YGo o4q//DIVj+IdxM2IsTQSE15XcLcagSw6+EtajaC0zHdWXJGKhqNhuIyGHHrIXo9QXYGVTdupFdU/ nhVp0VhnPQVnUQj+I5Fy79mG5zKI8SWZWHzhVVSTFzmmZ1E8zZnSMjHNgpVKltTZ3nmiqbmacfj1 aQmbZEIlHo5DVbXpjp3+Q2lqEdH1KEUNjWpqdIpG/2dmTgVZgdKjxMW63FlN0neQU2txiJxnFFXF Z0djxVJHHd0Z9MtOVsxCYa3XcWPXWOYlZJB3ywr6Z6Fs1TELSkKumJJW8o2lZIGWJbsshAVR2K2D w1lhb4GfvcVbTGlyWiy94BFnhWzr9YtZePZG212E1JZH4FM4glUVSZ4RakU315Zm2zI8NRTFVGMJ OW5K5coWBY5uDscpn2mSZ15KdQL3I6UxG9QqgWtWZBuh/yxGEnkIUvqtjydLeG7DYMknm03x/aji zD/yhSl+5LXVcnQ0g/doUU8ZXJ/UqLrn6kJLJ/eUhReWhlWdeMl5NENvR+yryuQ1kqZEsFXsLK+F jv+N1dDy/YPVMt5c0Y1vnvlFaUwY+e0wRIEHDuPj8gkUtuR9H/T3mFs7GHNid3Jzd0bxPgnVWakM 6PWveC5as+YOFd5Nf43/g+NU3cVyRSPc+Ba4dWNXpVfkpUU295hPqXcn7DyLuveg4LIO1pGPPipW 55FyPldLkqMd/fdjJs2V90RDXvzj1KkX4Xa8Lb+t6aSN/TVrs7wYv1zJf1ZRGjih93dDxzKVZ+xT IsfEanDg6155jjc5iPUPUK17lF0SZi9AOQ4ka4lFkAYYH9FNS3BSCpIIE5WzgmzOfDZSoPicY7n9 IcdHF0RerbDCs0y5B08Q3JoEPSWzjx1kRUKSoe3/aMgR2nTDZFOxjTfw8iFTpaEbVVpOAkkmwiAR ing2mpy6AmaaojyPL3rp4VSyJpABncYiZ/xH2yxCnjGSD4vS+55swpi2LBaEUlNpoxDtpL/RqeSL eeGhRSglHvXtUSL36cgJG/e2iqQxcHh8kwHPNxb66UYr7RGUc6yAFSVRcC0Ma9py5jUqgdjECoKq 1YPqYAVmSRFuluidFY7UH6z8wl4mA9wks3iddDlFYW6zY+mU5coAooeTE6nRQga4yU5S0AqgVE3K nqeZ2txmj8hk2kGssEp7raU/5DqIN36RhnvhhTljmYVWKKTOOlyBaXDEja6uOSnrwc2H20xJE0UZ /Cej8cWfZ7GLJlXCtDsF1IUppCT4DqUSEgpzPNiTVKnuhKB+kcc5HrMfjvbZQI4MlGSsEw9Fe8IX ba7FL46aS10Q8keInmWl5QOfFvsHvX+U0S2kO2dFZPMdF6YuQB+i3lEm9J00RIlEbsldajrkINc8 rmmwCVFBPlIo2PRsREjxkVV/yCIXHeSmNxKIXmaCU5LoFCI8rQhYN+IToAiFKB+yFY0gFyUuNU1+ dfAGSnTyIlfCJq+v2Qmgokq6qT4VPohNrGIXy9jGLkWJjo2sZCdL2cpa1it1OOFlN8vZznr2s14R VABBS9rSmva0k5UXalfL2ta6tisVBG1AAAAh+QQFCgD/ACwNAA4APwEUAAAI/wBRQdHyr6BBgwLr HPynBQqqhQWZQfkGsWJBKw4tatzIcaNAKx1DYnwYsuRCgVBSOowj62BDVJsWvqwokSJHlCpRfesC UYuhNKgMbTupMiUqliaTKl1qMaXCplDS8DRYJ2XFNFFjirTKtCtUkF4NYoQSlmPRs0MLVoUSZ+Ha q1nNnk2ZBmxBQ3PbGpyrMm3ZkiP/VnSqUaWhg28XbusLmKtgrynthu1Sh+BjiCmZydpsBUvcf2uh +AXt2ODilKMHQ9G8eZtAkv/iZJZl5Vvmvas30/acRutljWN/436qGjXV0nejQjm8lazwpZGfSyds UFZ00nR9Jz6IFyvzwlCI//+zDgVkF+oFbfcuiH78dekLgz9vv7DoeuwLNzlNOZXj2G2eYWFZQbL8 tFJLLuEVVGo+QYEFM74VpIVnQr130EgApmFIS3VQOOA/gZn201EIjmTFTwIa1EUcqBzV3z/0URca W8c5Z5B+4fG3UYzhgaijinHEMRWP4h20zYiG1BETXsxwtxqBLDoYR1p1oITFd5swg4qGo2GIhYYc eshej1Axg5VN26kV1T+eFWnRWGc9BWdRCP4jkXLv2YYnFojxJZlYfOFVVJMXOaZnUTzNmRIWMcmC lUpp1NneeaKpuZpx+PWZBptkQiUejkNVtemOnf5DaWoR0fUoRQ2Namp0ikb/Z2ZOBW2C0qPExbrc WU3Sd5BTa3GInGcUVcVnR2MZ0kUX3RkUx06byEJhrddtY9dY5iVkkHfLCvpnoWx1IQtKQq6Yklby jaVkgZYluyyEBVHYrYPDbWJvgZ+9xVtMaXJaLL3gEbeJbOv1i1l49kbbXYTUlkfgUziCVRVJnhG6 iRbXlmYbFjw1BMVUYwk5bkrlygYFjm4OxymfaZJnXkp1AvcjpTEb1CqBa1ZkG6H/LEYSeQhS+q2P J0t4bsNgySebTfH9qOLMP/KFKX7ktdVydDSD92hRTxlcn9SouufqQksn95SFF5aGVZ14yXk0Q29H 7KvK5NWRpkSwVewsr4WO/43V0PL9gxUW3zCjhW+e+UVpTBj57TBEgQcO4+PyCRS25H0f9PeYWzsY c2J3bnN3RvE+CdVZqAzo9a94Llqz5g4VrkV/jf+D41TdGcJMHdv4Frh1Y1elV+SlRTb3mE+pdyfs PIu696Dgsg7WkY8+KlbnkXI+V0uSox3992MmzZX3RENe/OPUqRfhdrwtv63ppI39NWuyvBi/XMl/ VpEVOKH3d0PHMpVn7FMix8RqcODrXnmONzmI9Q9QrXuUXRJmL0A5DiRrMUSQBhgf0U1LcFIKkggT lbOCbM58NlKg+Jxjuf0hx0cXRF6tsMKzTLkHTxDcmgQ9JbOPHWRFQpKh7f9oyBHaaMFkU7HNN/Dy IVNZQQtVWk4CSSbCIBGKeDaanLoCZpqiPI8veunhVLImkAGdxiJn/EfbLEKeMZIPi9L7nmzCmLYs FoRSU2mjEO2kv9Gp5It54aFFKCUe9e1RIvfpyAkb97aKpDFweHyTAc83FvrpRivtEZRzNoEVJVFw LQxr2nLmNSqB2GQTgqrVg7qwCWZJEW5p6N0mjtQfrMTBXiYD3CSzeJ10OUVhbrNj6ZTlygCih5MT qdFCBrjJTlJwE6BUTcqep5na3GaPyGTaQTaxSnutpT/kOsg34mCFe+GFOWORhVYopM4uMINpcMSN rq45KevBzYfbTEkTRRn8J6PxxZ9nsYsmVcK0OwXUhSmkJPgOpRISCnM82JNUqe6EoH6Rxzkesx+O 9tlAjgyUZKwTD0V7whdtrsUvjppLXRDyR4ieZaXlA58W+we9f5TRLaQ7Z0Vk8x0Xpi5AH6LeUSb0 HStEiURuyV1qOuQg1zyuabAJUUE+UijY9GxESPGRVX/IIhcd5KY3EoheZoJTkugUIjytCFg34hOg CIUoH7IVjSAXJS41TX5d+AZKdPIiV8Imr6/ZCaCiSrqpPhU+iE2sYhfL2MYuRYmOjaxkJ0vZylrW K1044WU3y9nOevazXhFUAEFL2tKa9rSTlRdqV8va1rq2KxUEbUAAADs= ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nrc/images/journal_header_v3.gif R0lGODlh2gN9ANUAAAB8iP///wBiaxaHkgB1gdTo6gBteAB5hYrCyKXQ1CaOmAB4hGyyuQBjbABn cABlbwBfaQBocgByfABqdVemrunz9AB0fgBwegBrdoq8wQB3gkaepwB7hzaXoPT5+nq7wQN+iQV/ ihR9hwpyfMXh4/r8/QmBjAJ8iAx8hgF9iP7+/7fZ3D+UnP3+/vz9/t3t7/j7/P7+/vD3+BF2fw12 gPv9/fb6+3m0ugdweu329wJ7hgdyfCCDjAJ6hQZ1fwVteCH5BAAAAAAALAAAAADaA30AAAb/QIhw SCwaj8ikcslsOp/QqHRKrVqv2Kx2y+16v+CweEwum8/otHrNbrvf8Lh8Tq/b7/i8fs/v+/+AgYKD hIWGh4iJiouMjY6PkJGSk5SVlpeYmZqbnJ2en6Choo8CpaanqKmqq6ytrq+wsbKztLW2t7i5uru8 vb6/wMHCw8TFxsfIycrLzM3Oz9DR0tPU1dbX2Nna29zd3t/g4eLj5OXm5+jp6uvs7e7vww3y8/T1 9vf4+fr7/P3+/wADChxIsKDBgwgTKlzIsKHDhxAjSpxIsaLFixgzatzIsaPHjyBDihxJsqTJkyhT qlzJsqXLlzBjypxJs6bNmzhz6tzJE+KD/59AgwodSrSo0aNIkypdyrSp06dQo0qdSrWq1atYs2rd yrWr169gw4odS7as2bNo06pdy7at27dw48qdS7eu3bt48+rdy7ev37+AAwseTLiw4cOIE3d1wLix 48eQI0ueTLmy5cuYM2vezLmz58+gQ4seTbq06dOoU6tezbq169ewY8ueTbu27du4c+vezbu379/A gwsfTry48ePIkytfzry58+fQo0ufTr26ddURsmvfzr279+/gw4sfT768+fPo06tfz769+/fw48uf T7++/fv48+vfz7+///8ABijggATy5wADHihQ4IIMNujggxBGKOGEFFZo4YUYZqjhhhHwUP+BDSw0 wOGIJJZo4okopqjiiiy2mOEEMMYo44w01mjjjTjmqGONM5AQQ4I7BinkkEQWaeSRSCap5JJMNunk k1BGKeWUVFZp5ZVYZqnlllx26eWXYCrZYwwBeMDCA2GmOeMPbLbp5ptwxinnnHTWaeedeOap5558 9unnn4CyqeaghBZq6KGIJqrookRi4OijkEYqqaM/jDDCpAbgoKmmP0zqKaSZjjDDqKNa2umnlPYY QAA/KoDqq7DGCukPM+AQ6Q84WGorqriKSuoMI5wK6wQ3ZGDsscgmq+yyzDbr7LPQRivttNRWa+21 2Gar7Q2yduvtt+CGK+645JZr7rnopqv/7rrstuvuu/DGey4OLBSQQASQ4jDDBhkg4G8GFPCwa6z6 soBAAWSuGkAFKzDAg7CS/qDACwmXycIEvVqq8a+kDjzrD6FqLDLEnuJAAQwZQLpvAiQUgIACJDs6 gggbJFCADQq7sMINPFwKK8IKBy300EQXbfTRSCet9NJMN+3001BHLfXUq74g79VYZ6311lx37fXX YIfttQFkl2322WiPwIANJaxQ9g883OBBwmTGYHcGPKCNNgYiMFABqxVU8EIFHqxqdwkM7KD3CBTI UHEMNgBMAQMJ+ItABjYXUEDLmlOA9r4UUNCv5ZZnoIDeZo9wA6sJXCrxCnbXHQMFF5SN/wEOCmQA gwsxyPBCAjZXYLcLCTyMOtkYFED18sw37/zz0EcvvdExvHD89dhnr/323Hfv/ffghy/++OSXb/75 6Kev/vrst+/++2XzkIHdAawwgQEjbCB8xUMXoMD9qKMXxap3gxmUjQLCU1gMGICDs4lgfvQL2uFK UIIIxu6CMeDW2TbwArbVgH8KuwEA9caDBLhgVQkAGQsoNjQZ8ACAfZvbwkwHMpDxAAE4i0EFKDCC 6wFtekAMohCHSMQiDs168EuiEpfIxCY68YlQjKIUp0jF882ABSQIWgLwd4PhUbBoMSgAD2qHNhww wHAv2MDZfnAyw+mQBW+rl9EG94IXaP+uAHX8kNAyuEZasUB0BWiBBG3AANTNgAI/jAECLrBCMG7g AnCD3aoKwAI2mY1NN8hhBhWHOuUZ8ZOgDKUoR4nGKprylKhMpSpXycpWutJ7F4ilLGdJywvQQAEI GNoKZrC6HJCgcgiwGQyItgIRGICWO2BABXtHAZDRUgFZVCAFMCDLFeTxhEFLEA94MIMfxNIAPFBA AkB4g2PWEmQGmMHfggYDBlBzllc0YQQDkAAOgjBozZwY/V4As1rGUgQJUFgOmunPC3iSlAhNqEIX 2jTrFfShEI2oRCdK0Ypa9KIYzahGN8rRjnr0oyANqUhHStKSmvSkHMXBBnK5x+ohIIz/nssUrmiQ gXUqMAYsoCUbEwaDFdTSABKLpuFoJ0sabLORQasArs5JrxoErQU3kKiPFEjIWdKABQmAAf9i4IIX yKAEm7Op4VywAR68wHAeeORDf3DGVblAjAU9KEPnSte6irJ6KM2rXvfK17769a+ADaxgB0tYvfqg AjCo4NDItIIx+rNxQ7vBDmYpAhkuDI7+hCb/CFrLcQaNBBBlQQJDKFETsrOQsvSQB4a52MjFEpFC ewEPYFe3FXgTogyw4A184E+52vW3wA2u815Q2OIa97jITa5yl8vc5v4VBzygwAfEajj/PdQACRBk 0FZAA1nuIANBK0BBgypBonYWmwHQ/9l1WSCDp0Y1oqY1XDtnuYM/IiAHQ6tBArpbOxas4KswoCQD 0FsCtRbUAFiUIAkcS0vfCvfBEI4w9Yjr3Apb+MIYzrCGN+xcCXj4wyAOsQRwcAEK5BcBJBbxhxEo tAKI4MOHzRkCVOxhzeLzAipOQAkU6DYaS2ADkcWxjyXwUnZSAAcgliV4hWYDNYKYBgzIwA0UIILR BgAGLFAxDUSgAApMNWgvyLKIHSzhMptZuMQdsprXzOY2u/nNcI6znOdM5zrb+c54zrOe98znPvv5 z4AOtI95sMcKbGDIF1CAb1/wYg/7QIEVUACNcSdUVlGAxl8OQA1WMGQTu1fNZiwcWv/FLGIW7FiB lPTxBTJwasOtIHQboECsRZcAFu5RBoce85l3zWu7Vk/QwA62sIdN7GIb+9jITrayl61nHqigxTxQ swgqvapoe9gCKyiBLxlwgR3Q2MYKu7SKxRoDn/qYAuRcM4KyKWkVi1ZojRWyiFFAZlZh0N5Fg8Ej dd3rfvublC9gtsAHTvCCG/zgCE+4wuFsgYY7/OEQd7gI2pszEqAg4g+XwLSF1gIePDxuAZMAxhtO aaFRYORnVdimR24BCXhaYVBlecMlsDaqKgDjEnh3zhLgA5z7YAMUN1wFgAe8YAJvBUhP+go490uP R7ze/4661J9XPZlb/epYz7rWt87/9a57/etgD7vYx072spv97GhPu9rXzva2y1wEvuX01VcwNKdz XbSbHbmVyy3ykaNbaDe4+roVZqa+Q1znCuM5AUauOwkioOU49oEEcEwAEVje8ijgAQtYEG0LLB7i UJ+66EcPtYC7/fSoT73qV8/61rv+9bCPvezJXnm5tmAFWKf7U+2udQLMz+QYJ0DKV7Xykbuc44GX Oc1xhtabYxzxAShBAi4+ckkqrAQn5/rnMR560nv/+2B8wezHT/7ym//86E+/+tevfQK4//3wj7/7 4Q5vz8s//roPGg/uz3/3yy8H2rUqLXBy92dlKoB7/fd3QXMD/fd+NUd4HSAB98cC//ilRT7Qf8Pn VhHYgBwof90HfiAIgi/QgSRYgiZ4giiYgiq4gizYgi74gjAYgzI4gzRYgzZ4gziYgzZIfzmzAiSY fwK4fyUoAhQAhAojAyzAfxmoM/1nAS8ngAzIgQ+4Kkh4fxagaEGjXyjAfyKQgemVhDL4gSE4hqM3 gjp4hmiYhmq4hmzYhm74hnAYh3IYgzyoMAjIgUYYAELIgX1DdzDAMkJTASygAQVYMQdof/engCHU gVMYADIgAoQof+CGQj4QifE3MRzHAIj4gmJIhp74b2Y4h6I4iqRYiqZ4iqiYiqpoghrQiq74irDY igtQh+m1ArF4i0YYAwNwi6+IAv8MsAIuIH0bAGWstSo5MIi3uIS2yIsa8IQBAFXM6IqNmAO8KAEd sITTd4tXSF0x8AHR+I232ImfOI679gLgeI7omI7quI7s2I7u+I7wGI/yOI/0WI/2eI/4mI/6uI/8 mI8DEHcEAI55yAPRWIQ4UwAUsAABuQE5UDHHeAC3aIA+yIzOGAA3AI6DZ4zMCH30tIW3iAIvEIDP mAABSY/iSI4oGWEj2I8s2ZIu+ZIwGZMyOZM0WZM2eZP0SIs6c45A2AIVAImxSAAdkAAUlwAd8IoM GTTHeIsEIFY7SZFDwwDgiACtFgDUyJQdIFbShwLM6IUBYI71eJIpOZbABZY4eZb/aJmWarmWbNmW bvmW+/iP8FaS0WiEBWACCxCLsLUqjUWIrkgBVYlrtzgAYnWAdKmXTEYBAlmVV3mLWSk0CdADzLgC IskqHXCY8CiWZLmZc2WWcPmZoBmaojmapFmaN7kAqJmaqrmaqamTK8CasNmTLsaaLDZJA7CaGtBW ClMAHYCbPaAATvmasImazohrw5maBBBfxnicj7lzKDCcB9B4jnec1DmcmsmZ2IlQL1Cd3Nmd3vmd 4Bme4jme5Fme5nme6Jme6rme7Nme7vme8Bmf8kmeAyBqdqgB3GmXt5maBwCc2iUDUsmaq/NZCoCf q6kADakwB0idzlgDFNAD1UkC/88mUMyZoIkXAgbKms2ZVLuYnteZnSAKSts5nyRaoiZ6oiiaoiq6 oizaoi76otB5ADI6ozRaowfQAwPAcStgozxqhCQgAjTaA/lXPSFgozrAUqtygApgo78pVrfHozNa kQwApTO6ANQlAybAoz2woSOZpTy6AAfgYDGQAFRqowswABSwpDb6oSHapkP0AmUap3I6p3Rap3Z6 p3iap3q6p3zap376p4AaqII6qIRaqIZ6qIhapgoAQq8pp0ZoAwPQAzOqAOilX2Bao9AkkiugAJdK o4QZNCoQmVRakQiAl1QKdEKTIJJqox1goSgUAp1qo424Ku1EpyFQa725pm66q/90BaeJ+qvAGqzC OqzEWqzGeqzImqzK+qdnKjSbFqcLEALUFgADMKM68IR/yKMUwHwK8wIdAKXUVQFU2gNAJjQ58K1Q 2gMkUJkygK41uqVOmQBe+qUm4JVW+QHQqgB0V6o8yqa8+q/DtawCO7AEW7AGe7AIm7AKm6g5KjQk YAKrCqUDMK2RKqM9sGQKQwI2mqkcRwE0igAfALEhyU7uyqpeSQK5WqMbMK1lsgEawKMdwK0odAJx ugFONTQesAIbAKUn8AEvEKoVq6sAO7Si5KsLe7RIm7RKu7RM27RO64xhVK1UqgNyKUFSewAAoJtU OKUzCgLZ9QIV2K0bEAIbkG3/H1CklClB/mOtK4WyJhBQQqMCv5OmCtABv4hfDBC2q1ICCMCkOrAB EyqAK3C1UKoDWhuIBfABFNABCrABH1BrOJMAhFuj/kq0lvs0Ruu0mru5nNu5nvu5oHsAh2uVFKAD ZVqb+ESjHcA/KpADCMC4XtYCRpmHOQC2VqkAppuRClMBv2RN7SWvB0AB9pmFORA4hBN9Y0tdZbIC RLcBpnsAH4CzHhunIXADlRk0NiADgZMDHqBdkhuxQnu54htEmRu65nu+6Ju+6ru+dWoCFKC3SfoC XGukHVAAgSuAO2SxJuBgLpAD3Fs/1Tq6Kue8NxoCykt8exuyMnoCSHo0aWS6/wc8SQgwADqAS8N7 hPUUpyegTEwDAzcwr1BaueM7wnPEviZ8wiicwipMrBzQwi78wi+cASSQAzLLZL/TAS1MtjZTw9nE MBsAAApwNKWqAxwQAtF7RBsAAi/cRkWDsiHwwibQwEQzwQDQwuGKAGlqAuJUADJwv3HrAb4kuScA wy18Ah2QtkizqUpMxjAswiT8xmDGxnI8x3Rcx3Z8x3icx3q8x3zcx378x4AcyII8yIRcyIZ8yIic yIq8yHpMAo7syKTjL49cADrbwrj0yL8UySzzyB8AACBQv0KjMx3wxC4cAmc8TDZAAgwwAGP8wilA AV4ouxRgAlUMw2S7rkLzh/+j/MLrlLgKYAImoMQnMLGPzLyRHEyYjLJ0bMoJAL+rUgGvawJ47MZw DMcvwMjYnM3avM3c3M3e/M3gHM7iPM7ZHAIhYALmnM7pjM7sHAJVDADnDMzoHAIgoM7nfM9lbAKO C7IbMAC0TMYnEM/ovMZkDAAmYLcIwAD9HAKtzMYBPQD7zAAdgM5kHEy//MQNzQEpIM8DnQLqXM/3 jM4ZzcbwrMWTA7KLO9B5TM3VTMLXTM4wHdMyPdM0XdM2fdM4ndOCDAAn0NMnQMSDDAApAAK1XMc9 nQInAABFTdLhzNNJvdQr3dJSHTUvrdNWfdVYndVavdVc3dVe/dXZzNJTfbn/VQ3WZn3WaJ3War3W 2KzUbv3WcM3Rcj3XdF3Xdn3XeJ3Xer3XfN3Xfv3XwJwCcK3UYj3WRPsCg53Yir3YjN3Yjv3YkB3Z kj3ZlF3Zln3ZmJ3Zmr3ZnN3Znv3ZoB3aoj3ajP0Bpn3aqJ3aqr3arN3arv3asB3bsj3btF3bsT1l iV3Yhg2wiE3avv3bwB3cwj3cxF3cxn3cyJ3cyr3czN3ckq3bu82rve3c1F3d1n3d2J3d2r3d3N3d 3u3clQsDHmAD6JVQNWADHlADXhzdozTd3/3e8B3f8j3f9F3f9n3f1f2hHvACK5DQj0sCFVCV3YpH eHTAJVBHePQCxWiVBN5B/0Tjk7/0AZRjTaJWAxXQ4BheR6xVAhduRx6e4MfL3kvj3vhd4iZ+4iie 4ipu2fdszy4u2Izt0fPs4jSezkRd4+ZsAjA+2Dhe0jgeAkM94z/u4iBd40Tt0T++40Jd4zCuxXWr AAowAERt0P6c208DVgyg43B9xpVZAe7s1uXaYlpu0HC7KgwA4ykgoYFolEKt1C0MAutmaEoO11i4 MAow50ptyj57syLuwCv+54Ae6II+6NzNAQxw6IiO6BK+6IurAF8O1xs9OTeQ6Aww6YvOAJd+6Gm6 ATcg4ZSO6Qqg2BuA6YmuuAAw6qT+6bNst5VO6ZZO6hI+6Zo+OZ5O6aGOpv+1TukbQMtuPQCfrrjA vFIhKUibxgBR/gEoa+VNAwOlqtgp8AELLru8rtQmUMMtwE9vLbwK08lKPbGx9cOJDQIDcFYDtdif 7EkV0AGN/bZ83udEQ+KEHu/yPu/0Xu+WDTy4zE4U1ALa5cscMNgDEExGWAMUVPAlUAN8ngOHTgLd 22IroO6J/YsNXzUIkAKUkwATP0kJ8AFomgArUAEiSfAGT0F8vgKPC7+/swEpoADI3j8NM+1A7PGf 9TJH7EuOXAAw4JO1RgJ3PtgnqV8a/daPzkFDQwGPLtRo3K0DsOMDkAA3y+0A4O27C/Fu7dHUnl2k i+duXZvp7tgpkIfu3q3/9j72ZF/2Zi/vHFDmMoAAsTbqH+9WvDnlkA4CVBluoXP3d/+LNmBoQn2N QYMAjs0BG4AzfPvWQ70BxZgAQ63kfj+SeP/4tUZPKZACrZqxAwDpcrOblz/Y/54CudQCgA8AueQC JADu8MwAQsXzyr40qq/UKYDrEi1OOLv5Ve+M1x7qbn0ASRkAUC/1V3bmVW+3H7ABjYtN5a7U4s64 yg/tz0z1K8+4uO/mYR72sXX21n/92J/97x3EVRPMk58CHIBA2uWti72hMY7xKi/UDFCMDPDvjo1f K+D+bw1NxMcAil3m9q/Ygv+HeQ4EiMBwFQIckaHEMLAapJBRQGoTKKRA/5SAizTgRDmmhC1AUkCl BeaazZQxvkfFqlW3rSrthHeKHLTYXp6iTIQCPvxImEhMohjIhgpIXIZyKNBCPjwqOF9kVIYqOqLw KpzQAEJg2lhbXV9hY2VnaWtlX6RydXd5e31/gYOFh4mLjY+Rk5WXmZudn6GjpaepdTkGmF4UchlW hxAadRXyhsKtNzwokBQUA1oQjHwVajxGpVIGlgJsGHRB9AMwiOdvBYkjHKoMebEhVwoGHkLZ05Ui QY0bAAa8CFBBna58ZbblUjOrSxJDsCiAODIo1cghLbTd25AH0cp2AVIeweeNlSUkhV62EYUkhUZ3 l3SayGGLaVOnT6Hawv9VjWpVq1exZtW6lWtXr1+vYlOoIM66my86oIoyjok5cSTgIWEAyEqHsrs+ 1Fih1s+KIfx2AbwRgi8SEAwC+BlZAsFdm0yQ6jJRwcOZDgpZ5uqQo8AZkbNaJCg7J5YMlgxUAgCR d40gviGE1MTYrnJqABRquLKERgxdoRIBuIwMwESMqMeRJ1fuaipY58+hR5c+nXp161vFBoh572SJ jvfYlus1gMF3AB1cMigcBYQa80hODPC7r19DgAJ5gVCAICliIm51QoCSAPbw5zKDHFIIuFwS6EwX l2DJoT4AOEAvlgKPYGSdNWAKSYrN+HusjAGIQqAE3b5LgYIEWGxwjaH/dCIBhhrMQEWB5XDMUUep ruvRxx+BDFLIIYkcLxuyuPFtQinCCwDAiVBJ4SQzHItigxpeeHIlOugLjInB1tMJBNs6gKSCDQrb wCgZ7NIlgRJuwIKB3EpIQMsjGDDDNiQgfIUjK8l5hYJwUmATE6MwgyIEc5RAAI0B2sHwiBVObGU3 vECJKAoKbmBAAcKQOGnHUUkdtbkiUU1V1VVZbdVVsTrU5YM13tOpyTvJe5IKcmqolZQWZMtFvr+W JOq+gdjbYEEQhv3mrSFqQC0XECqAIaSE9gFnIgoQWPCIPpljSKcNZIClHlth+CA12JiINRUFSJyC gQkh/cYcigbsyVcK/0WFcYoUAFZrA55KLdjg4051VeGFGW7Y4YeVyU4bx8TIpoM91wn0zg1aQFKK ioewcz0FZKghMynkAwQwN78E9R64KPZvxFwoCLQkKaowaKVACfQWow5O/nYWbVCZyTdWnJALhhVS o8I3147oQFoAFPCw3gAGIyXfNi6V1Td/czFBakQPLtvsWhKGWO212W7bbR9h3Q4JDmp+yc6JbrWG gQrilYKDh4aQQdxcEGhhL16aXfmeY/2pINgj9Ftqo/dAEDWAZZf4LpN2ayjgAw91ChPcVs6cu4Ob WsGPQhLqMGcActx1SGdh20Ggbykr1dewDT7o/QPU/a1wIBNmPdv44/9hSfvt5Zlv3vnnk5HY46gL yK0uXprcBT1BMLaJLnBe0whNxLlUXIr7/Jn1gypT/mZPBQrghK6sf/LABhNsM4HLNUj4IOgHZ8ER G6GuDWwqCwN6NzyAQO02hqIdEfoGAAbkjmuR6Q3pgLOCPcTBQsjz4Ae1Az0RjpCEJWxedgrQiGt0 4AMuIYHPbBUoBMyQhjNUQwEiCIYPmAl0R6BACbI0nvmYz1hD4EINaZgAGKSrISHQwhDM4Ig6IaBc VrgdBQx3j49wqAkMuBOfZmED2eBjPq1IWi+y8JLtgGADLkiARxTRAgchATcoMokrwPYCYA0EWyD0 Y9mUZ0JBDpKQhbz/TnY80KIVuBABnsEez1zRmSrJoQB08aJa/KIeIaqsWEgAyCtKsD5ddKACnCxL RTzlkg2UxS/D8cMHIBmApY1vF6MzYxRScIOjsWFqvVAARLTDkg7AQBR8uVoL0vKTWDKha0DBYBQq WQG3EPCP1dxRIA2ZTW1uk5vSyA60nnaDHuINdvOaFwXMqQgc5mdKHuKAAnIAgxwKa4idnAJAEmBO dM4LAR5gokdOEiL9FIBNAJjPO8IxgHjeiQqfdAdMbtA9oQ0NdPtZAwLKKJEUmGAAHR1A00wQx+1Q YSmOQtlNPoAsCoxEjpqohOYQAIMczDQH1dIUGAOwAds80Zo91RE2/7sZVKEOlagoYwJHNgC4AOTg AwD7RfY48AWAfaEDK5gYL4x2lCgIIQESjUL7iOhJJkwIYAcIw5xEqQue1kiCTXjC3kIRr7kcDnEU oKYHwPeZWcBANISgwF83YAJ2gORRBSnIC5PgHwbOZCPJTMRRHRm1v1LALrpcamRSoIANKGuzVQUE 2EaSgOHZ0qeldQpQi5pa1a6WhHEjkZRe4hNfZFZjDckC33oBstDEKyOXC1NfiDURxk3rBY8zDPyG 4AH1VAw1G1UlFBRBy10ATAEMIBt9ukdaVqTjHmNCA2JSCrk6uqMGIZqCAlQQu818Qy1X+889nHoN RcgWl2iAbWOhWf8JD6nItP1FGGsBHGABn/BIX9iiFRTg1Yy1ZRdVmJ5aq3iu23RunvTkpJeGAKZp wWwXsKHLGzvwghw4Fp+CnSn+gtEByxUzDbaoABwQtxDbJOBoJEDFANSwWMmxWERMSMA4HXHZ3wLA EKCFjMte518lNwW1A3byk6EcJOkhIcR2++J5a9sQEwQWjSFlAvgU4cpdJM6eFBkrso4LZDq+pDMM cKM56tYCGZigG6LF5ZanawIKIApYegVNCyqQgMERJU93wykTbIDLG1iBUE0y7+ra4Ll5qlgjORh0 Q4rsTpcUAJc8XfKnY9HkKI+a1KX2ivTicBjrKXeSCxZPMj5QRRn/VG2mH/0FWO0JAMG4DL6+ZJ0s P0BjGB/BBKpUwyqZdIVeqOnLJlCLdl/xAhIkgIYFyUELckACbWubYFDcNgnUYINvFyB32f52Fdng gQKsIIkk0OMQSiCJb8+bBKUMQLzPzb9xg5rfyTP1vwEecK3EzZ3OBDQMscxgX4CgAzDE8UtWxNcr A7dL9jmzL66RE1wWTzs5QAt7TBSJjcxzHgjHwkkkNVGntGCJFHxJHV4BczbIfOa7bEUJSgADmz+0 Dj33OYd6zoqf95vorBC1wJGedKXfusBrKeMpdpE3eZBg2ISz3gvI0KZbly/Xux5yJmZnJcmFjNcA 2MDYA6AtJgGr/9VHYHba+XDoos+d7j09+tLxnvekE1wmRqmBcWOo8DwnQG65ePt7gUFm4V68Fx3A ay7eWUac3MPLTJDuQeZRADTjsoNNbXHdQR96D95d76U3fZRRLYXDMCEdEpU6L3Aj2jApgVZD/uoK KBHWI3gdcSSY9URkhljCAVMQ4nABY3oxwaVeOjiid/7zDUb600+f+qmtUDYqDLKNML9CgRoyBWTw BjQyFsHBeCdt7PmPl2hyIl62cYONgoDupYCUAYhBXPx2owA8viHNwn9+oS8ABVA5pK/6DPAAtYk1 hOxZAkftkOADcqdbGm4CG25FPECOIksXQmA+/u8XOqBSVKCvkv+NCQpAWShwAj9AI9IlTD5CBXIN BOYDhhRgQEqABC7tdHJjBYAM2gawB32wFQoQAYVwCJ2HA3rnTdYgBxLgAygH/FpjCT+AAcagXUrA A6zwCq0QEgjE9gBAE2oA4X6CdxCAZwwnCsWmd/rEBrDwCm1gQHJAzeSlBaJoIm6gBivsnbRjJGDg BTRokYDpxwojBXjwBwnxB4OQCBExEdXmAxCAEZGIEcUsCx6RER0RiSzREplPA/mwwj6GWy5xhrxo Az5xFGnI83gBRDbPD3KgA9fCNEKAPAjIBVYgsMKEAUjxFnExF3VxF3mxF33xF4ExGIVxGIUxrRTx GJGRecYkBED/IGCwIASY0R+YcRmhEQSY0RnHJBu1MRsDBhjoLwN5AQua0RnFEQq4kRy3MR3HxBcE Cw7d7n+ITVxSABrFprNMAMWmaxrJcR/5sR/98R8BMiAFciAJsiAN8iARMiEVciH3MRuT8SEhMiKd w6mioRsl8iIxMiM1ciM5siM98iNBMiRFciRJsiRN8iRRMiVVciVZsiVd8iVhMiZlciZpsiZt8iZx Mid1cid5sid98ieBMiiFciiJsiiN8iiRMimVcimZsimd8imhMiqlciqpsiqt8iqxMiu1ciu5siu9 8ivBMizFcizJsizN8izRMi3Vci3Zsi3d8i3hMi7lci7psi7tQPIu8TIv9XIv+bIv/fIvATMwBXMw CbMwDfMwETMxFXMxGbMxHfMxITMyJXMyKbMyLfMyMTMzNXMzObMzPfMIggAAOw== ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/__chars/math/special/sim/black/med/base/glyph.gif R0lGODlhCwAKAIAAAAAAAMDAwCH5BAEAAAEALAAAAAALAAoAQAINjI+pCB2+opzUuAaqLgA7 ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: image/jpeg; image/spj Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nrc/journal/v6/n4/thumbs/nrc1840-f1.jpg /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAAHgAA/+4ADkFkb2JlAGTAAAAAAf/b AIQAEAsLCwwLEAwMEBcPDQ8XGxQQEBQbHxcXFxcXHx4XGhoaGhceHiMlJyUjHi8vMzMvL0BAQEBA QEBAQEBAQEBAQAERDw8RExEVEhIVFBEUERQaFBYWFBomGhocGhomMCMeHh4eIzArLicnJy4rNTUw MDU1QEA/QEBAQEBAQEBAQEBA/8AAEQgAlACWAwEiAAIRAQMRAf/EAJMAAAMBAQEBAAAAAAAAAAAA AAACAwEEBQYBAQEBAQEAAAAAAAAAAAAAAAABAgMEEAABAwIDBAcFBgYDAQAAAAABABECEgMhMQRB UXETYYGRwSIyFKGx0VIFQmJykiMz4YKyQ1M0onMkFREAAgIABgECBAcAAAAAAAAAAAERAiExQVES A2FxIpGxUhPwocHhMkJy/9oADAMBAAIRAxEAPwD7s5oQcykuG4AOXESL4glsFkoxIiCTgBiSuG9r JmVMAXOUY+biTsVr0rhtNOIiTIDAu+1Q0QEom4fNORc8CwC52bmEdKpRLFGqvW8bglAb5ESj1rts 3RdG6QzHeElyEWY4g5hc2hJE6XdjODncFE2mVpNSd6nKOoc0zjSTgDEuOjNPKQjEyOQDlZGVThiC MwengtmBDC6RUZDmDc4iRuUpSvHyTpOREnLFdSleg36gzHmG8b+pQEB6p8bkew/FUqlvPasQhTap bz2oqlvPasUp6mzD7QMtg6UBaqW89qKpbz2pISqBywLOC46kyA2qW89qKpbz2rEIBhKTHE5b+kIW DI8O8IQh1HMrEHMrFogl2BuQMRnmOIXj3tUdObkYSoiZeLDESOBAXraq9ybE7g8wDR4nAL5/Vx/8 75muH9QXDttDSWbz9D0dFOUt5J/mdQ1Oph/cMnfCWK7NH5IStZl4irYftyK47kQJxG0uyv8ATbhh flZPluBx+IfwWKWatVPGfma7KzWzWEfI9AWyDVK5KQALxLUnqAXmanS6zUWbY0k6TCcjc8Zi4IFI cZr1jiG3qVoCyBalLxSJMcGfo4r01txcrQ8tqpqHqeXP6f8AU5QaMqTv5sl3fTLGp0+m5eqlXdqk XqMsDliV1oVt2uyhxuSvWk5U7HOY0SMNmceB+CFS8MBP5TjwOCmSACSWAzJWEbEvQjKLzJEYOS23 BcWsOosWbUtPbMKv3T55wDYR2rqnMUm9ccWbYqZsZN9pvcuf/wC19PZ65N+Eraray9qb9Cc61a5N ejD6de1Vyc43HlZA8M5Bi+7ILuUhcFyNvU2nlGYAO+iW3HcqgxJIBBIzZZiDTsrOUo9AQhChDRke HeEIGR4d4QqDpOZWLTmVipDh+qS/Ttw+aTnqH8V5msj/AOX+e3/UF6H1Tz2R0S7lxaz/AFR/2W/6 wvNbHsfiD19WFK+WdN6LXYDeJKUTy9RbnukPey6tS3Ot8JLju+YcR707FDXgnW5VvJ7MrluJaU4g jYSAslOxMUylCQOxwvO1P0eV7W3NULsRzG8Ji7MKd6mfoUzehdN6IokJECGbEdK9fHrhe/T6dTxc uzH2a76HqUXI+Sbj5Z4/8s/eluX52YGdyAEY5kSHeArLl1xtysm1KQrOMYs7tvG5c1i0jpAsNYdT VajAW5EFqpO/5fitjCpp3DWcCHwiOEVyaU0343L45UY5eEDHjFdsMYBslqyhwg0S1v8Ap3yf8cvc vBGo0vpaXFX/AFhfSEAhjiNyzl2/kj2BdOvsVVDU4znByv1uzlOMIyk4tPB9BZmZGiNoeELptjT2 gaJRc5lw5W3jDlyt1iBIYYO3UmjGzMVRiCPwt7wubctvdnRKElshgQQ4yOSFrIUKAyPDvCFoyPDv CEIXOZST5rigRI21EhOcyhCnm/URdptSuiIIkR4STnjtHQvNvl70RfMxpvBTQzV1faXt6+2bmmk2 cPGOrP2LwrguXbgtyJjY8MgYh3kC+K898Oyd0evoadP8yenekDIF/GxpXMxnctx2ylEe1NOYJB2h 2T6GHM1Ylstio8cgpZ8nVbkquKu9j1kIWLseYFzajRW78xccxuAM+whdKETacoHGfp9X7k3jtYF/ aSqWoiNuEYhgAAB0K1yTQkRm2HEqYDADctKztmwwQhCpCd2LRlcBkCA+B3JoxlF6pmfFu5LfqMJQ pNJGMgQG7Umo1Q01ieovQIjAh4ggnEsqk3CWpHClvJF0LhtfVrV3yW5Y9Mfiku/W9NaJErc8N1J7 1r7V5iDP3KRMnpDI8O8ISiY5RuNhRU21s0LEGpOmRAJfDFY4Z9m9ZdhC4DCYqicwVL0lh3py2OW3 ZKMpbPpC8fV6SenmTEPZljE7B90r0KbU7pjKEScQfmDbTxTnTachjbiQcwQsWqnHjFGqXamMngzx hVMtAGUjgAM162j0x09ppY3JYzPd1LLOm0xqlyLcSJSiDEZgFlT09j/HHsWa0Vc3LSg3fsdsEoTc lEKZ01iTPAYYBnC2FuFtxAM+a0cx0IWEgAk4AZlQolwuYx/mPVl7ViyLl5HOWzcNgUrguVmnmMfl MWy2OuiUIyyyFC1G7Ims3ItlUYkHsCY6cmVXNnwfBUht8E2ZgByQwG/tTXLdu7EwuRE4HMHEFTPM 5xeltlT5dDLbXMeflbYz0ut8YrykzylxHgUaHRjKzEcAg6DRSzsQPEKn6+6HafgsMrsTGoRaUhHA l8epTlb6n8S8a7L4FBEUmLeFmboyQtG3h3oWSlJzhGTSkATkCUCQIBiXBxBCndBnepcAAOCQCan6 URFMIxF0eEMSBEP1ZBZZScH9ZcP3WPQ1KpK8D4bJE57xjGPSSlEIiRucxjJ3PhbZ8E7EYczLY0UY NhEQgIjFtu/pTJIkDEzEh1beCaqOGIxyxWSmrEIUKCnI1lh5Bn0kfBBJnhHCG2W/gmAYMMAt1rqy NiksCTsxwU/UWtlRbPwyw9iqQ4bfuU/Txd67n5itmR4kSDjI9S0kAEnADElT9PH5p/nKwQqPLBJt 2z4iS7yzEeAQDQBk9yY83lidkfiU7LVzG1cHlty2gfqb0B0JLv8Ab/GO9ZVeH9rL7wWSMzRXGlpx bF3zQFhkeHehaMjw70ICN+xC5clK6CDlVHd7wgaSxLGJJGLsQxJwK6JDxHilMIkuRjvyPao1syYb Hi3NfZt6m5YFky5cqQa/lwBalLd1lq1EGVrZsuYsC/yL1ZfT9JKZmbYM5FzIgEk9aw/TtKc7cOuE V1nrw9r84/uc+N8fcvH4gTTWbOp09u+xiLsSTBwfN5tiqNJajKpy4IkCWwIwVIWRCAhAmMI4RjEA ADsTcuO0Pxx964urlxgjqohSpZlYPkFR6Mu1ZSZecuPlGX8UXbMLoAmCQMmJHuSjSwBeqZ2sZFux VUSDYSldD02zLNsWySHV6YSolcEZ5GOLg7lXkWyXY/ml8Vz3dPeiDTKq2SfAIPJj94yW0q6smJSO r08zRamJ3MWgMyyauYl4oNAO83yboUbdq6Z2xelhJyI0UHAZVCTq8tNalExIOOHml8UarODwGJhn IxNIMSRgcKh0smtiItxEPK2G/rXLHRCWUiaXiJCRGRXRDS24QEfEW21Sx9qtlXQzV21KMhkh01ol zV+Y/FPGAhGmLsN+OawaBlO6P2/xjvVmU7o/b/HHvVA4GfDvQtAzQgGIxKxk5GKGVggjIZOyGSAI yGTshkgELtmcyDC7K2QG8LEHqkk9Nfd/Uz7I/BdTIZIBy+mvsANTN3cmmOI3ZI9Nff8A2Z8KYfBd TIZIBOVuMw0sRnux3hLyHwlcmY7nA9oAKpOEpRaMqD8wD+9T5Opy5wbfSHSAOIgAABgMAAsmaYmT GTbBmt5dz/IR1DvChq7Mzp5VfrRDE2y0QQDvARLyJK25VxqMTDolmmZeNRCmr0nh2wcs/wA2S9LR 2pjTxp/RiXIthpMD0kLTpGokuyS7GRopDtME9AxxT8u5/kPZH4KU5NIg6gQbYQFmBJYDNCURlyie Zi1XMbZnkhIBdkUpkLRBaUUpkIBaUUpkIBaUUpkIBaUUpkICV61cnCm3cNqXzACR9qjHS6qMDH1U pSLNIwjgy60IDl9PrHDakM/i/TGS6DEHgic4wDywCn6qwSAJO+WBQGeltdLfK+CrSBgFM6qyA5Jz IyOxB1NkO8mYPkUCSWRSlRuaU3J1c2cd0QzD2JjqrIzkQ+WB+CPVWGJqyxOByQD8vwUVF2arbxQl GoskEiXlxOe1CAqhCEAIQhACEIQAhCEAIQhACEIQGLPC4yfYhCAW/wDs3PM9J/b8+X2elefb5zh/ WM/2qN23ahCAwc6kU+tbY/Ldv5u9UHMYf7FX8tTeHPYhCqzM3/iysOZTcfnuwZ6Xz+yhCFfgY0/t l+p//9k= ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: image/jpeg; image/spj Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/nrc/journal/v6/n4/thumbs/nrc1840-f2.jpg /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAAHgAA/+4ADkFkb2JlAGTAAAAAAf/b AIQAEAsLCwwLEAwMEBcPDQ8XGxQQEBQbHxcXFxcXHx4XGhoaGhceHiMlJyUjHi8vMzMvL0BAQEBA QEBAQEBAQEBAQAERDw8RExEVEhIVFBEUERQaFBYWFBomGhocGhomMCMeHh4eIzArLicnJy4rNTUw MDU1QEA/QEBAQEBAQEBAQEBA/8AAEQgAeQCWAwEiAAIRAQMRAf/EAIgAAAMBAQEBAAAAAAAAAAAA AAACAwQBBQYBAQEBAQAAAAAAAAAAAAAAAAABAgMQAAIBAgQEAwYFAgQHAAAAAAECEQADITESBEFR IhNhcbGBkTJCFAWhwVJyI9EV4dIzJPCCkkNTc5MRAQEAAgICAQUBAAAAAAAAAAABERIhAjFRA/Bh cSIyQf/aAAwDAQACEQMRAD8A+1baITPevA45OR8RLfhOFc+lSAO/fw46zJxJx99WJxqTORfW2DmJ 8IGdZzVwuhVECSzaREtiT5mgXrZJAOIrOz3SzJZCysamcmJOMACpoX71/QASCNIJIAHEcYnOs7Vd Y2G6gBJnCuDcWyQBOPhUFuB5RgUcZqeXMcxS2819lJ3q6xy/tbncDWWcwWYg3mQSxygK0j0qP0u5 RZQuzEmZ3L4DmJSvQY4mo3nZCkH4jpH7jlPhWss4QTbXi/8AJcuKnNb7E4ZYFBWi0tu04HeuOwGT mRlHKludxrhS0dJC4uw1AScOmRJwqfX9SF1Y9vExgX/VpmptV1jb3VpRubR5+6s/dZW0XVhj8JXE N5cj4VwD1PrUnerrFr+3W6cblxOoN0OVyERhwqQ2VoOX718k5g3Gj3Voc41DdMUslwJII6ec4VrP LOB9In/nv/8A0NKtu0FJ+ovMBGbHnI4eyuO7lilu4E0gKbjDXJicBI4HE0iMO3uAeBYL5AZDyqbV cKfTI8MNxuBjJGsjLCDhV7d20iBNTNpwlsWPmay7e7pCW3IB0jPCeRk8Sacjqbzqb3ODWNP1Fvxw 8KKzgYHy/OirtTENc3CI7KQ7FcTpRmz/AGiptjuVuQ2lVIkA540r7pLV65KnEhZkQSMBH58qU/cV GBQychI/48udQ2ntqVlM6RBOJwImuKgVmYTLmTy9lZvr1j/TM4ErOIn+nHlTLvVdwgU4nSTIgH+n Ks2Vdp7PucLfdHx2pYRxHzL7RXUiVjwpb7LpZSQBBzMSaXb3VcWwCGIgMwMjUBj406wq9++tt9PU W+KFVm6Rn8IqV49ztFQ0Bgx6SCB7aXcbm3a3TsymEWCwyxM4eNc/uCyQUIxgGRBJ8eXjWrnKZntp FxSYE+4iudte53MdUR4Vm/uC5G22qJ0SJjL38hQPuCEhQhJwnEYTx/ryrNlXae2i6ge2VyOankwx B9hqVptdtHIgsAxHicTT3LiLgxAHGfSs9m8ioLerW6zqIBAzyE8adYtatxurdpyp1SIJIVmUDPEq OQqG4vrcXtIr6iRmjiMYk9OXjTb24iPcRgStxQXYR0gfnyqZ3tsXGvFTBUKMRjiSPXHlWr5Y2ntT cMVW3I09QGBmRxFcuIq30QYrcJ1z4ZRyqVzdrcI1KykGVEjMccRly50p3RLByCXT5SBMNhw486nK 7dWgWl77KVm32wsHEEcqWwW61YyFYgE4kjNT7qq7nt8CxE4GB76x6nZmCuqFuq4LcFsABxqdZa1W 0ZHy/OipqE0OAwI44YDIZUVrCLFoYgiRJxFI9wgjQoac5OkjlnXLthXdiWYEnHSxFdS2qSAWM/qJ PrUvUy6l2QSy6SOAOr0oJJy6R+NdijCmsMpPYtHUxWSR6Cm28m3aLDS+ldQgAgkCRApb1lbglmIV QekGBXdoloWrb2xAuBXMGZJANaRZyQ7YSJ4Z0j3NIGhQxygnTh7aL9m3cuEtM+BI9KW3Yt2vgBEi MWJ9TUs5WV1LpJOtQsY4EN6V0sTkI8TnXYoiprDJDatsRqUNGU450u3L9saxpMsAsQQAxA/CnuW+ 4unUVxxj0qO0t2ivdVeqWXUTMhWK/lWhrukhzhIw86m1yFlRJ/STp9a7uLSvckkggfKSKRLK2zIZ jw6mJ9alnJLw6t1iYdAo4EMG9KYsTkI8TRFEVNYZTezbuRrExOE5zzqCbdXLKztAYhgvSD7atfuN bA06ROZYxFRsm4AzWgLouMWOkaQG455mtQXFm2EZI6SumJOXKiuL9TocnRqgaVE8xM0URdh1HzpS Qok5CkuXL4dgLOpZwIYYjnjU9w+47cC1gR1NqkrjwVRJ9hpjk8RS1et3Z0ThzBX1rl+wLygSBpMy VDetZLdy7bZlVyZ4lHY4cNJOEVc394oH+11SMxc/LRVvXCde07eMmtW1t/wBiWHUxUBQAcBMc6vb XSQJJx41msNuBltgquxZmN2TjxgrVrb3y6hrWkTidQMVFVuDrNLFLfe+txtFnuLhBDAE+w1O4+57 fTYBkGQXiB7AZoLRRFeX1alWTH/ruDHlp1VoO43lu0hWwHUYA6ipYZfCVJB9tW9bDLS56lQMQzTg ADgOJmmVSM2n2AelZLFzdOz3fpgCzCZuwRAiMU4VoL7jVAsyJz1jKoq90ddJFPcHVSxS+UjkURWK 1DtKsqgYjVrHHxatqSVBJDHiVy9lMKm9uxq13ACW545VyxJNySDLEqASRp4cMKLrw4RCTcMMwBPS sxMDnwqhso3xDURxONAwGdFKLSaCmkaTw9tFBQ5muVi3X3F7O4uWRZLhQCGBGJPCCRVE3buoMICR JBbEVrTt6Y36+Mm0LZvtdcSHyuAfDzUxjjzrl3cK1v8AiJYMQGdQSFE45cabvvh8EnAdXGlbeEHH RP7qadvRv1+op9Razkx+1v6V23etuwCkzPFSPUUu33BvMRhgJkGauBiKlmLirO0szENzdvWrki2G tz8UsTlxCqax7X7um4vm2UKIwJsvDYhT83Thzr0rocz2yA3AtJH4V4d+632+6va26JuGDMXIGnSP lUdzj4VL7b6SXjGbfD1k7F1u6gDOuGqMR76n9SA9zuKW7dzQhVSYBVTJPtp7O7F63buC3cAugMJW QJ5kSKXbdu4+7WVcC9DLgf8At28CKMlXfbX6kWMVuuBJIgaokKx/VFaq8679lsd831BZdQfsAKAW By1HhWu2oRtSbYoxwJBTn+6i3XjF/wA5/Kl+wr3dep1aAOliB7qm21Vk0F7mEmQ7A48ypE1pcdVZ /qOBs3QeA0/mKXymULiMu4tJpBLAw0ACIxlZxinfZBse7cQ5ko7KvsXVAptw8rpKlMcLjkKAY+Ug zNR7rvhcuB1BjtyAX90TNa5oe1s0ZA5u3mDAEHuOMP8Aqqh2qE6tVyfB2iht0qmGt3AR4L/mpxeJ E9q4BE5Lj7mNZMqDjRUxeJB/iuYDkOfnRQyzbr7devblrq3FVT8pAPCMZU0q/bt0sRcTAR8I/wAt ekc6K3tWNZ5ef9DueD2wZwIUYYz+mlH22/qlmtssRpKgD8Fr0qKbU1jLtdq1hmYhRqEQg/wFaRnX aBnUvNzVkkmIGzNSuWtveA7qJcAxGoBo8pqxGJrHudozG32LVuA38mpR8PhhTCnvm+FX6YAkZgRl +NZ1Td2jca1aCtdbXcIAlngLqPTyFdt7NrzBrtr6btXNSC3ADgRi3uqybW+bd+3evlhdPQRmg8Kl 6ef2sXP2XXVpGoQ0CR48a7WexZ3Vm6tsuG2qJAJ+MtzNaatiFe7bFzQXUNE6SQDFI1+yq6muKF5y OFUuW7bnrQN5gGuC1bC6AgC5QBAoInc25ClXk4gacTUbVyzYuPL9DwQCepCMwwJmnv2WtslxcbQI DiTKqc2masy7YWwWK6BiGJ/PjTg4S+rtOyqlxVQGWZmAkD5QCeNWN6yDBuLPLUK5Ytr2w2jSWxg4 mOGfhT9u2cSqz5CoO0V2ig7RFNFEVULFEU0URQLFFNFEUHj/AHVHO6Vld0AUDpaBnx6WqVtgltVJ DxhqZzqPn01o+5HTuAwzCjKfVahb3TggQSTwYuRj/wAsVw7Y27Zd+udZhq2Go3iSoAKyIMziK9CK xbJma91Rq0mYyzFb4rp8X8sfJ/RYoimiiK25vN+8KzdrSzKRJ6THhjgayWm7aEF+4QZJdzOPkgrb 91w7ZGYmM8/ZWJNy6Geo8gTcI5Zaa49sbXLt1zrMKWzed00ALJ6WDE4z5VoXZ7teoNb1jIhIx4nO ktOzXreuJ1j4f8a9SKvxyWXm+U+S4s/CVlbi2wLp1PjJp4pooiusjkWKKaKKDtFFFUFFFFAUUUUC lVOJAJ8qNCfpHupqKBQqjEADypqKKAooooOFQcwD50pVQDCgngKeigzhr0j/AG4GOeoe/Klvbttu Fa+EtKx06meBqiYyrVSXfhoMf91sYddrGY/lEEjMTHKup9yR8U7biYJW4GiecVb5fbQMxQKu9BVm hOkA/wCopGJjOiqDI+VFOE/b7P/Z ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/common/images/table_thumb.gif R0lGODlhlgBuAJEAAP///8zMzJmZmQAAACH5BAAAAAAALAAAAACWAG4AAAL/lI+py+0Po5y02ouz 3rz7D4biSJbmiabqyrZsAMfyTNf2jef6zvd+vfgJh8Si8RgLIpfMplOnfEqn1GG0is1qYdet97vs gsfknriMTs/O6naZ7Y574fJ6dQHI6/f8vv8PGCg4SFhoeOiHh7jI2Oj4CJmnGElZaXkpOIm5ydm5 qPnjKTraCOpDipqaqbAXqvoKC2DaE1uLOstjq+uJu7P7i6kJPBwrTHx8y6pnxyyz2dss96ycF908 ndBqbYeNgPydCr0N/ihuTe5oHo1eSg2wTcPOaCxf355tn5/urt9fSO8vYCJ3Lgoa9MZHkwCBARcm JMjQn8M9CiP2m6inosV8/xglQdxor6OsjyDlidRYkt1JggdbtuiDMiW5lfgkyVQJk+TNbzQRenQJ FEXOmrIsiQR0FKmhpAkJMaU4qOcBqEWaLnNm9d9Sp1yjen1IdGFVqFdjwDz0NGugtDa/VsNaFKzP omMzajOr1q1epXv/YJxhV+5Uu3XbvsVLVqviTF0Zl4URmKJOSGwjN+6b6DLfw5ANZ4RYOK5mwHnX XibtebPqn3PFEim9GrVlx7TfwRVt+nGA2SPD2h4C2y8f2alz15Zd+S9cqQaovk68lzju2qqRn14+ tLXRrdw1C8d8VjfviqErp5bekbhyxLiti+cdXrLv8t05786r/m5nz+7tQ///Lp929C3mH363tXfb evshyB5bzGHkGnD/GVfgf/m9x1+C+t1XXHyf+VaJedNRR+FqAJaYmWDNEfYcfCeCl2KFDC6oIIcz cvigcxK6GKN31WmI4Y3QoZYjizt2+CKJPza44ZBAVlikTQP6aOKSNDZpWX+/7RfliOnUB6OHVYqZ JJnktZghe0iWyWZwammZ5JlHCulmj0qS2SOcdvYmIJp0TojimHVm+aSJcgrx5oFeCopno4kySWJM lIF5556WOgpoaQoFxWkJ2Q225k67dCmiqKqQaipPn64oJTzXoLUqhFu6Kg2sKspKKzOIoJorN7YG COqiqdqC6rDEFGssMKRKdspsCLEmyxE/0M4k7bQ8VWvtMQBlO8y23P6iTq9pUOaOuLqWU665dZBL lLrrokvUt9piK++o9NZL7L34FqPvvq946++/zQ4MVAEAOw== ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/__chars/beta/black/med/base/glyph.gif R0lGODlhCgALAJEAAAAAAP///////wAAACH5BAEAAAIALAAAAAAKAAsAAAIWlIGmAtr72JJnNhSr g9zFDASYNXVTAQA7 ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://ad.doubleclick.net/ad/naturereviews.cancer/article;abr=!NN2;tile=1;type=rv;artid=nrc1840;date=200604;issue=4;subco=;chaco=;keywd=;njdis=;njreg=;crstg=;pos=right;fidid=7;posid=10;plaid=157;prisp=75;sz=160x600;ptile=2;ord=123456789? R0lGODlhoABYAuZ/AI2Njf34bZRSjjtUoEpdp4qtC6GiWnCRCJQuF+61LvPNMERERLRGFDEwKvbq WdBpGe/v7v33iuSuWNONLvXRSct3IeWXJgN5oQ8ODJ9Oeteljru7uy8pcd/f33YhF/bv0CgwAFIq Zs/PzxBacKxSHikxStfTScRVFCcUSzdIBHV1dUlMMaenp6qpztGxys7PdlZtBzQ3ibaKsu7YzcrM kRcTRr3MY/jhN9uFH2hxSbhtKnB1NGRkZPHRZd2iMbe4dLxjHKy/NPDFjphEJf/5sNDPqqI+F9vV 38XCPfXYquvd5ImAsiYNNOKNIT5DlVRVU7fK1nRKh9/oqRoUIMDClkVZBBgeAB8fWcRcHGV9CB8c G9zG2UJwb1FHhVpfONPgkMt/SOqkJ+bn64mKONvazCQiLH+JWjEfW7W1r8XI2ujm19x9Idl1G66u rtq+xCQ8WsWevodMRuXgVYK2xHA4bkF4u6x0mYM0HoE2Lenjfqywlc6xq5e/Df///wAAAP///yH/ C05FVFNDQVBFMi4wAwEDAAAh+QQFLAF/ACwAAAAAoABYAgAH/4B+goOEhYaHiImKi4yNjo+QkZKT lJWWl5iZmpucnZ6foKGio6SlpqeoqaqrrK2ur7CxsrO0tba3uLm6u7y9vr/AwcLDxMXGx8jJysvM zc7P0NHS09TV1r9PLG3XrWUqAAuSPG0QfX0b3KsY5eZPkTwA7OjpqSrm5vORAPj0qfv3+SDZO/es QbhYWtj1ATDpX0BlGEQwlNWgzYaJkgY+RBaxj4plDiM14MSDhSAMKjZsaMMD0QIWIsyJYKGFkJaY C/1gWMCzZ81CPg01ECHoiUWMfrLFhLCh5aEG8QxpYdEBoFNCGv0saHOvzUFCT6rKBIBUEoZ96J4o lImBEIYNff+8vjQHoW3Stffy5hSEE2ChgX7+mfvYAO6GJ1oWwBUxUhBUsX0K/QPHA26fDo0FORSc 92rgPiJqauEamRIPsR14xAVgmd/JcttO3iO8AbJcnoI/ElLtWmvrgQAblDNJqGoHuwBUkC4tiIW5 zH6c94GQeWA5iSnzHtRi7idf5pGW0828IK9dy9793MPIvZ3b9Yb8fs4L4YlgFuXqFpKOtMG9QU+Y U5YfOB2n2Wy73dOBIICBBV4kCd3jWXT3hOMfaIUg6FiFNmlIiHw6QaabUSpIF9tJgi34oTmDiAWd ILx5xGBvg7Q20j+6DfJgJK3ZNQhwFk7nzop7acXhIOUJGJ//OSfO18dXfrRH1wZ95ZUhi0ZiaQg7 RM03YJI5xdifJa0ZAuZ2h3h4JiFg5qijkj/e46MfwIHTEzzfqDDkm6X906Uh0pU2kJuDsGPSOgpO SIllG62JSKBfOSoImAN66OR+RzbyH500EiJYW5MdwmhRa23woiSjApXpbpA9ieSqbS5ZJKdaCtIa lIts+o+KZnI46CEhOdZqH4pCkiqbq/pxWmoXujoprPBdKeMgghXS2p6MbAqcS7rC+Ze3OsWTF7Y8 dpqlszot1pakkp5LqHrgbktIoAMmou09p2YJwYzTFkJaS1p4N5qClRz7qjkHIWrguZFCO5isblaL FcGObCpl/73/EBeqIVXpR1YhMaZnrLmOSndVjA0jjCy45yIl7yBSzjoIStLWaA6vhJB20K+FXDiR Cjjb+tyidPWqsh/s7HmrIIlZ2uzCOvWFlMTz5kXoTWVt6kezVzNJLct+qHsgrvvsSwlkhgCnG0Bt qaCQCE9cJGUHTywwjhaQdQAAPB201oEWdkFaSEcKJgcAVyLMCS94vFGXM2g+WvcVBs45PqPlIcrs iBacteHdE33BTSFdHVDX2nRtnW5OSwHqtVDM59itELM2VZlXvVqTag4LT1R2juLiTqcSbHP+AwEA TwCteSOFqeS8SiNZ9LxKALx1DwttUQ5BB9g71hdNANoWTv95eoejxfTPT8hDlSzgyqchKG1QTgdt kDszPCq1AYDIWuEm/f6qSIwjMJAvneCqgI9oAP9q1o9g5K6BvTAXBGnBAxXYJUnvmqAskpQ4ZU1n gRqERYxEcBpihRAXwYuL+07Iwha68IUwjKEMZ0jDGtrwhjjMoQ53yMMe+vCHQAyiEIdIREQoroib AAEMDsAHPhwgBUdEoiSsUIUDFKCJWGxiAbKQAilGwgopsGIWbfAFKSgBAlKwARa3aAUvJgIDKcjC FbEYhBdIoQNQWIIA9mgHF0DgC0HA4gFg0EY3wnGJWQyCDaQAgTwSwAlOIMAeJykAGWwBAi8IZBOf GMUeKpH/iWNkJBRaQIAYQPKUBIgCJSkpgyN8QI1a5KIPqShGLJLxA0doQR1O6YQYmPKUXVilMO0A BzTCkg9svCEY5TjGL3xADC1YAgEG8MtT+pKXThCmNgXQxz9q0omEhCEcmUnHMorBDTLYYxcGgE1r YjOY29ymJTH5TU6GMAWIpOMi1bAFGdhhklGQZjvdiU0CSDKe8nTlMbfYxXR8Mot8ICMEtgCHf66S AHWYZhcG2ktsDsCgqVQlQodZzDSuMQuFjAYt59jEWx7BBRZdZUAz6gQOrJOj1TwlB0xpUHiOdJhu 8KYgw7mMZbKUD0EwZx4RSgBpxoADZzjDTnNK0F5y4Aoo/4gqT1P5020u4Qj0FCQUizHOo9bxjtHs 5Uczqs0l1IGaUO1CDOR6hhpcQao27QIHrlqDvtYABYCVagwwKtKuUhKkc+jAK0/aUF/gE5RNVKQU 1JCGJdR0r5jd6kH3mFFf4vWuZwhBFN7g16yeAQV+Te1fTWtKthp2kiA1aB1aYMyhptQWD20mBNJA Sl9i9re/dcIAMorRUkIVBTG4gmqvoNy+nla10A1sDIa7WcPGdgDYjSRtASnIKtzWFSttJi6jWYeM stOXT93rFYC71+mWt6anhSp0+9rc+c43qzvFqE/3mAFh9nePBj0vZpl7BRVA4QOZFGsnR2HURDpT CdEMMP8kh2veXvoWs3jF7HB7eVqp2rcGwI3Bh/saWA5Esg7w/K8A+vvfKLh4o5e9KoFnzAEVHMGk sWysKMrq4Mm+VI8uju1bhVveaULywuqF6nThGl/U2vcKT4UyB0ZM4qzytA6qzICKBUCAjSJ5xmAO cwwAIAYcg/O7mTgkZJG6z37GVAYyWAKQu9AF2T7SCUW+M5KlGkn4mpbKdq0vlUvsXiwLIArTvPAZ wszoRjO3Cy1QA3c36V1NWOGoEu1ARVW8ZTvAGchdBumQKWxk9HLgDW996p/pC2hAoxawOz3xLtPr 6FoTWKp4veYAlnDgBG9yrJZg4i37cIR0UpLF/KWkp/3/eego1Dm2hTaohaW916wKutWtJnRxnWBr MC/624vObDXRW+cltKADZmYoJTDQRHNsIaaT3PKWJ7lsPR56o3aGZHFLSdM607nVWI0qYJ38YUKv ldvdpvF622tN39YZ0V5+qhOWoAYzDxLNjGCiGsgsA04n2+NaVvanm03n2BJ5mqmOQQiWMNcpjxi0 UV00YAuOAoa/N+HMFbdws/tUXz7bwnvF9V4hLel6VtoRMODDF55Qgg28G9lQX7HUkU3vkd/72e+N gXmfGvMz0Nnlfy2taQ9NhxCcluCqHbhgZV3rXPsSuzyfKiQ3qtcBAzcEoo1CNxFcT2ArIgURBUAZ nqAH/zHAIeqIn3rI++tpOMT56uu0MzuDjtW+5pWvVT6DHYBMh7Pbt8Q7/Sh2sTpjtwsXpNSkqhPk GnSo/jYEdFDlEmQAB8dbVAZKMLMTMT4IKyC1DSV4whjMUIQj2CHxyF9xyCsJ53++mMippjzBRXtV J5tWj0CWahdIm3ZCnz7G4sZubFGPXXKHAKox3yveY89N2tte+VqOvwDcUGZYHmARTTxC8M2wgzHo QQ0uMHUCiHzxF3KNZ28cUFwCVn1Odmt8NXB5FwV0QAc2FQLdh1+xNlwDwAHstHPjR1wCNlcqF1V3 pX6wF1C05wK2V4As2IIyUA6BxHuCwEQfMAJesAM7YP8GZuB/EHB8LfiDLAh/3FR7LIdRNJVeZzdw qXVXaod3eAdzYbdaGGhKa1UHVxBgojZNqddeXXB+JKh+7Dd7cKCCduCDQPiDduAGM6ABH+BEi5B0 X1AHOdB/Y7ADXuAFOUAGWwB/8rd4Zwh/m7dOIAh0AjdwrxZYOdd1hriIUdVeS2aEMfAGkaSFviVV IaBX4MYBeOdinuYCnuhPZxiKuDcDE/AAE/AFfAADiwB4NjAHc8h/OXCHdxgPHad4BWiLfBhy0rRO e2VNQed5i3iFMSBwSbiIphVuJlaFqfdIlaiJI9iImhh7jeeJmxaKoegCa1iKbMAGQqBGOnYIvhcE UDD/h3Moiytwh2ZABkpghrn4gwDlbHrFXE5mSnsmc2qHa4UYjDF3bWcgazvFAVGAfqGFfpqYd9MY TdIkSdYIhK00A2BAAiewjduYBDHICE2kBjmQkV6wAhzZkXioB0pweEJ4iwD1dTKGdvT1S6ZGeevF hCgAc12XYYHWXEzABC8JVwRQAksgkOunSsTkiQj5UVgYBQvJgnugBEIwAQxgBCRAAmsgkWqATI3A RFKgkR25Ag3QABy5kTmwAetIklxGZ1HGXPM1Y30lXEeGZL8FjeyFWX4lj6slWELZBYh2gpU0hioo A6inhaKnkEVpB1uwhjqAAxZQAQxAAgzABk85AW14/3+MAIcAcJVYmZWUuQJzaABiEIBhyXXPVZaB Bl1XIHodiF5q+Y+keU2CllWAVZP4NV2nJAPUCIoht5dCKZREaY3FtAdxQAIPoANhEAY4cJhOuQZr IAGoqIqMwIoAQJlZGTABo5V4mJE7gAZiEAVnxwTRZVeuhpai2YHupHrZdVd+ZZOGWJM2qX10dptB SH5wN01+iYZu8AEagAcN4AFDMAQIoAMW8AAMwABYgANNgAPdyAcg0AjhiAbM2QAYgAFakJXnGJ0Z mY4scG0ouZ3c9gbXBXfspKHtaVBThmuriZ2FaJPnmYxdQAfrqYXuKX6p9INwoARJoAN34AE06gEN QP8CTHmfRjAEWNAEPtqGfLBghdBEZKBAzcmgDeqgsrikZMYD2EZicblXH3VVFFZeGWVe1FVcVrqB MxcCI2ieZxAFIRBYZRdf9NgF8see4vdR6pkBfaQGGqADWDAEd3AHCNCUHoAHu0kCd4AHPGoBgAoB UukINOicCxowZVCZHrmVeCgCaVACg/aSgkWFREZNVnqpmJqpWcdwO2V2JDqBAscETmhlvXSiXLai K8qmWiYDM/ABEmAETMkAJ/AAvNkEFjAEDRAHcQAEQ4AHd0ACE2ABEiAFfJAFjwCHT7CgSFoGSeqg HLkAkukFZqA30SWpcuedE1YHyVWlmtqtVuqaeqb/cmNqk2Zndqq5AHjXiNyZqn25BHugBkngA0Dg AXf6ACcgqxYQBjqAADW6m0OQp3cwBCQgBC/AB1XwCKz4ERgwBYiaoAZhECuwAFrJkU+QAyxwBGNq WhkIdx3VUVQYAqHprd5KYaZ0VUtmVV8aWiVwWiUAWGUQAiVgdja1oWvaVAfWAwkQBkBwB0bwAA+A BSdwrydgAbwqozTqpzPqq3iwB2pUoI4QjtiDpIiaqMw5mQnakUDTAhPGsa7pi663tSyKhX3ZneVH haZ2sunlqShgdmdAoubJtmcwV+LXAmIwAxKgADlrBHcKtFjABjhQAbDKAA+QAAlQATR6BzqABzT6 /69RyQeR0ESJw7ANS7VX67DQipUA0AGWtXNoiWFKGLccxZ0bik2eVYJcd2oZaGFOyAShdVrmWZNT kFUlYFNpIAYaQAJA8AAVUAEksLcPwAY+igV3igOIWQFNkKMeoANG4AFa0KeNGQk0eKjOWQaUm5US 67CUuQBv8AYLkAZpwIxBZ4zSNVWnWb6nOVV1VWJ6VXNvEHpAxwGdJ6pR9bo16Q0dkAQPaQSHCatN +QBrYKsWcLwIUAGEq7P+CQQJ4AN4gAeAywQeAAbHGQnIKrlTi70WbBAjMALbqwJisARKKIVRNaYZ 1pYkvJZ1VWWXuHrQ6JoXhnes67pTUAIsAK8UYP8Bvbu7FQAE/bnDQLAGgGsEOEC4eGuYDIADCqAA //qQNMoC3hgJCbuwFPycF5ygGVzF29sGjxpYoVV2ohWTXvzFimiIKMzFXrZw0wW+BRlVKpAGHxAB N/DGPnAHPnDECdCUhNsEvHuYQIADYUDHQEACRGwBE9CnQwAEhusGFQkJUAvFzjm5U5yVGXwBIyDJ GswDxVZ2dMADxCQDnSe+nvzJM7dasDeBeOdlVzW7ovdUXUAVSeAAb/zGCmAEE3DECqC8YUC4OasD /UkC/xkGTYC7CaAAxLuUf4wHOlDHZDCoj8sHicPIjeycDVC9lFvFkTzJkvwGVAFWR9AGApCu+Qj/ ymL8YaLqphkggU54ZKccA0vAxrerAK98AwowASQQzPEsy7icAGuQnzhAq7i7Bn38xmGAmPOswDqg ABLwvJJQqFOw0Av9zFrArNFMvdTboNV8ARZ90ZXMT8bGxR3myU+aWmvLR1pGyl66eksgBviLBXdQ Ae78ygkwBHOsAD5gBGtwz00wBBUAqBUAtMAMx4FLAhTgAx4QBzeQBxEsCRM8BVDM0A7NrMz60CXw BpF80VQ9AjlgAEUAARVlzt4sxhX6pFnFAxNYhhkwgVHgR0KQswG90v57ywoAyEcc0ARcwMeL0z9L wEMMyLfqAUYABLJcAX2aABHQtJOgnAGz0Avb/6AS+8xPnahRLdXWTNWSbAYGYAA/oAbGJwAcnY8f DdJaLFrdTAfEdAT4a6u3HAZDUNAJYAE4wAY4+gA4gANAgABrgANPWQH3CcgTkADvTAG8C5FG4AMU gJh6iwc+AKRCmgjhuAGNvNALYI5PLcXMub2QLdlcUNmWbQA0oNWazcXm+sFPGnAhfIKwScNN4LM4 4AMJMMhzfAMUoABhQNNNsAYnUMgPkLsPgABAYAH0/MYO4MoK8NtYwNsOoLw7igdgIKgFUAlNJAYT HTALwAVcULGx6JF3KLHXWwJRXcUXTdk/kN0/8APqaAcSuNnf/GRYdYxOOIGjKAEPcMsJcN7+6/8D TQnjYUC0Trm7vKy7sb3T6t3SN/DfrgzYhYwFFUABN6CU+jsEYECsxkoJNBjNJVAGU1AGIyDhXMAD GrmkG3m9WfnYkM0FIf7hIW7ZP0AFEBCAJe6EcPvN9xhzKy4AxZQEa/AA530CQZyz9N2rAiurRt6z Ok3Tsc0GtIoFhp7T7uwAAZDkhczb8nzkOrzkAFCwB0sJcMgDGl4CC1oGXFAHKiCHGRmLXvAEGxmx Xl4Gmb4AZj7mqx7iZAABG03S5RrCtF6uKy7aW6AGPYC3TdC3FsAGERkGE4AFJECnRtCjwayzSE4B COzeQxzEPlCYQGDkEzABOewDchAAAeAAhun/1zhqBEtL2JSgnG+g4dkzeFygAnOIg3ZY6lh56om6 AgZgA2Ne7/ae1W52aGVNylzs3Zg8gXIOo2DQy2HAn/7pszjan/Vd5LCdADrgA/+93q78xoUb5G9M Aautw4BMAYqu7QHw1jgNuAgwBDPQRJYQjlCwvQqa2NS7AOzO7mMwBgawA5SZqIm6Ay+QBy9gAy9Q 5vYe4lRABa/uAv4UUy4We2Yde4x3ST3gyz97AlgABOodnL068jl9q7u92jig0mug3gT8ygrwADGd ABIwAT6sAySgA0Dw8B3vADNtBGqvtzqA0AzOBxBA3UrNyA2w7jBvAA4w2DswmV5gAHlQ+Dq///P0 /vNnHvSXrQR5WfRlWIZ8RExisAdy+ps3bq9B67/7yrP9CQS2OgT9fQO7m7O8XAE+q8MnYMgVMAFz /N8Yv+0BjsBu39d82rtDYJypeAk0WMUloBOMvAIw338mEAAREAEBkAc9UPjHb/iH3/OKH/RUoAcG gOYQoAQz4AZusAcq2M1R4AZKoAFDoL9Di/n7CfV0ygC1rcOaj7u0/MYDvugs/d83EAZHHuT/7fEO kAAeDwgBDhMkDw8VCTh3QwhGSTZ8KX6TlJWWl5MwfF9cI55TfhiiUw07pjtjQRGrAauurxF5eS+0 Nj+3uD9UVHoGvkV9wX0QWwJLWzNgCAh3J/8MDDhhCdJNDMtGDAkKCmsMDydGFds3NwpANwEUFQ4B 7QkU7fHxCfIRATcPDFgW7yR3RkY+BOFjBZNBgyn42Jhz4cKIN6FEYdCy4pQBdvbawXolaxatXLd2 UflhAIABM3rE9FECBw4EIRPYnEDgQZ+zB2FyTgDSaF8FLAluUPCBBYsRoArIWZjgwEETeO0c+JAn jwK7Vu0kAAFCiIQFCv6GBOTD56BZS1b4BIHS8BOGiBgaeEElp55dWLJofQS5q9fJk2aKiPkgYY3h NVjuIHjAJh+DCk0eAKzwjd+aE2HKJajgAZuPpEAUpMNxNYAPqFQVwLPnQB0JH00tADECJKz/Dil8 DpzdPYkshLYjSkjEMIXUGCTySrPa2FEvSF28fJk0c1INGzaH1/hD0KTJZQZGGDGYkCCBIWk4gFjY lgABuHBhgMBLMLXd0Kb4myb4OnQn17oBKOCAAiQgQEJ4YHzBRxW87XYAHx845NAIxQ2nxRjx4CeI Rq1sFMsstvDVly++UGcddoaxYURnTVhggYqKLRYGew8AlcgJFtyQAAnYSWYEThTgYFVTE0gThotI UrYTAySQAFl5CbAD1h1NDqEBJCA0eJYmX9Qh4QhlaFEhcV4AqKFyzH04y3Mi+WVSSSei+MA1LVqw xh2dAXECEDMqkMAaD1gQRhPiJKBDE1A+//MAEFgsesgJOPgApQ8++FfBBD5IQMGmPhxiGRY6hGfE DGS9peVBCS00QlthhjmFFhiUcZEDcsjRlCBoeuhRiCHt8oObvnRQAXY4aLfMY3Yy4AEC0OCABQPr bXNZBRZUUOkQUBJIAqhbOXPUCSdgsZUOWFRgFVYaRbApBV0hEtYHuZ1qVlprNeRQGfjmW9wKJjRl a1S5bvSFR7nQQEURfpEYGBgnMMaGNdhgYWy4WLBxZD4TsCfTA4AOQQKUFgyRjxETkHMDDrbekF+U VKHLjhxADFEbFiQMcRsfWchrlm+rOlSCFviWEOZEGNJ6lYbpMufRXlTQUMSvJZphxgYMg//73jNG FGjEGhZggeN++VQgTQJNFIWFxy7WeAd5JEAlhwWlRQWVPXRHFUAPJDAggQMJxDyEHS8sqPNBD6ph rydvlKC4vjkYzY7jSXsoRR40vEDDLQYXQQVgOXSuR9XPNOIMTT+22ES41EiGGXuXLaIPdiSQ4yQ7 71DVGoe4NwWGETqgpgMzewyU5eCYcOnlqognrrjQC9Sah+O3Ru4KEatMXvkLIm1uRg4rLNBAGQCA Dh6zK3pwwho4tJgPFk3gwIZRiGwTxgN34BFOdzqUU5tVcFNFgWjxyEgADJU1psTDBM+4A6nKQjxM pIoh9poQ4hS3ABPUymi1qgtGXkG9CFD/jwhS+EItbgGAHCzACqbygwoYxgBvYYMmCGiUIb7xjIo1 BjxrABvN7vCMPa3DB9bywcke9ziWtUwCYuldfihggRaRAF66aeAl6MWWCALnIW+ooPMckIcMAqhD sPhgBET4gluYYQWwskT4rDa+FfGwh+DymqIYM5OsNawJOmjGM56BAx0UiW9we1w66MGhHrRLUvRp Ig4YU4EKJIgPMJAiJgrABzFYMYKI84IFu+jFC4LRg6BcBfVESJIcNEAUoUilH8I3w5nAEBvOqCG4 eui1E+DBA83gGmca9aI2OgkIiFgXuzLlAzDoIG/hkNQ21nWDCniGBFeKhCQv8aAPeOKS/8AxQwZl IYcu0kp6Huwg9WZhAC/Aajio9MMThDBDLHjgnYtxxixpmQ9vMaMzDQOCByqmHZIZAQc7aYQRGoEA RiyCBEBYgw8sEKnoaUQC2NjbENwwkIJMsxJc4sEb3tCzS/7AeZ3MQ9KIQNKSvuIFBljAFIiDzrdg YAEaaOc7PTCE68QRHDFEn2SYAZB3GsEZHjhQQc3VttZggQLlodRrtLGNpCC1ZQGAqBEkEFUPqIEP BbioJVIFAMVxtKMN4YINvPg8pLWCpB/4QB8+0MFY2ACNYlppS1+qAathgSadYQNlwHXDxVxmoD99 FjzxhMv25Y8BVtnMEnHQ1CHdrmU+AP9IfWqGmyhqdRL02kC+SrDRCAbBi7cSaYfQqla2djAAefiB F8KkhdbKFZ0w3aM17Gcg7AyUBIZ5z09v2MLyvfMOCT2mAhigsoXi5wZhwME7VGafAK4iD7sjAVUj oAwNKIhBl6UEJTvwvXx9dQRmeMEF0VRSIpjWpPbIw1vx1VrXvlYiMI2lNRRjDTYQSk8Su2sjHoCD ZIFnpndQTHiGEIYhqIw8rfFTE4RYmm+iSwIHAkIPspI1KWApu5So5gJaFbQ3eGGs0aNbeUm6kXbk wQQ5KEF3Weta2AqhUaPDJU0CxTUaAmSgDFhDi8LgTJ+SAJe/rcAdgoKIcmzDgPIA4Cr/eqCDJIoW byfwAbz4kMLsZrS77X1CEEK8Eeo5lxWCkIMBlJev9sZ1OAsQwnW+8VsYFqsJD1tGw6zBAESVxwL4 PMEQCBtUD+TkNapxwA0mYLvV5IEQtNkbK3RwggnkAYoYpgRXW9uqMZiAuVC1ne26aAAsJq7MZn5t mtfsTp8qqzNewzEQcJCexZRHAU1+mBwPBNw7tG8IQmyHNHCXAEPi19FV0dMEIiAE3OQs0n7IbAOW 7YVZOTTT+Ym2HGzQCSwqDsvtLY5cZ0BqAM9kWctYzLMgdToj8MMHHpgADl7Zwrx5bA1GgI0gJtAD LkpAAqFi0gN8kAfW2IMCXht2HjQQ/zjsIpuSakAFEpBgsjMJEmD+shWtamUCMyRvo8tjr3u3fZ3G LOvHP+0MPKn1sIbBGyf6PJI7MeBTbMiWSTTz2IHAwwAg+KAHr/gXhE8AhlWAIXgEQfYkqmmCohvd ghKPtrQ7WasfeOLpGyWzxrM9BW6jjw3vnFMMwT1QBIjtdPp4lg48gIgwsAEBWvAAHvAQYIDIk0nW cBKmTlOPCMjBKj5gkg9WIQEFkkXomdjECxaOhKMjPYNKZzrFc+DpqCtPaGXWdtXR1z5mGOIaNYGM 1j4FLppoYz8/ZvsQfstD7jwAqUgOEBijkgBCMEAHOI9AD4aAh6taFtmp+gISgkD4wv8XvZP+mjjF jz5mxzt+eZBn8atmkL4mGoFK1cBrIwflSn7wGBx+vjP9AjxTmjICoJDJtSAIKQ+tYIPQHSIBHuKg oEgCnl5SMEAQ5N/73yvei0dHQoqNj3HkJ99Vk9cdTQBy3gFDl1IkYXBX8VYeAxhUFbAGlDF6+nRL 3ocAQNAeH8Mym5IhEpAPTjJhWOEDeAIAkCAJgOcHlPQBY0Ai88d7hnd4+Ed83eV//lcG/8daMxAu 2OFOd4ADFUA6fCI2KtcIiOQDQzAEe5Q3d3BMQEZTAJEA7zQNAmIB9SYBOxEuFQCCGoFu70RRQXeC 1WQAK1gA9Od7JmCGL5h/O0AcZTD/BZuVcUJzg2FCBvJ1ankTQ+AhNv3VRK40I5sRYLGEDdhwhHt2 hAgwAXgyAROgA2AABD1yCPJGFWAwUwgAAVh1gpNQBZvwA2PQiWXYe763cGcIirt3SqPghvmSikGj imUgAo0RS3iVV46hY9GQXDzBJ2a3ItBwJFoTbgIVbgPmMRIjKWYVDwYwU3gwBJWFiX6QKlTQiZ0Y BNJIirsHiry3cGPgUhIheazYjWlQLI3xDXhlBPaFNZBhJBYADhzzLCtygQowAR7gA/oET77YE+KS GcyFGlExdqT3SAb3fmohAqYAjWNoAAXQgivoiStIIuV0CegkeWLCYWEiAunDaqwG/wR4sgzPwiw1 hwj7EQY0Zwh7lDHoNgGc0X1OGB6LghRfIRQcGAcAZiB7cGHMiHBeMBeoQJDQeApjkJPQKIbDk06T 0FLaJiZmJgKm4yKD8nzksww3FB45UTaN4D53ZC0K4HXodk8z5TF2lA0KEChGNCUAxkOjUirM6AfV tAJqeZM4eQo7wJZsuQM5kJM7gEJDiQlECZFpgCQ5kVzL0Bn5sF/G4iSzRI7vwwbagAi84wPLUAGj 906ESI6IdQMNYxX4xme4lDUHAmlneWUNkAJqGZrLNprLtpZeMJdyaSpV5pBwsY1TsAGC0peJIFBU ggMFYiCy0XUV8wyNgSh+4kw25/+UJKADcVA/tDcEziQBCpA1eVQ/KClzRhAHxnaWzagQADCaZQAC DaAF39Na20mapsk9lbCaB4FOadAdgjINd4IFE8AA/2AU81UBNQMQtdQw/JAUE3CPjckAYUABTYaZ 3bd2HtAA7yR6VYIABCc4Z5lZ3vM9yzZ1lMadpbkCN7kClOBSDaKN4dNCjQKBVBIG8hhgQEAoPNVf zsQsErMe5ABwOPFOD6MN+0Ygt0Sga3dLAmqjMldQHgB0FnWWlEQGpDmaZmZmZTCaa9kAF9qaWgIA +VmYMHQoL0ITQ4AYzOCOPgAOcQdMlPINP+gBevIO7jictGejN1qg22IUK1KWDET/nQ/yBWhAmiw2 pN5ppMs2lHPVICogAUgCZzzBdcDkRr94gRdTFP/FdYQoFvPJlDRRP3FApmqHB2azZ50xBLZHnZOQ EHwgBW/6oNspp95ZpKRpp9qGTruhAj0wNtNgASC3keAGjNjAJ2RjX0wFRDemGDyUN+VSM2NKJWOa jMOpV88XYHigA+1nqZdKFlJwnQ/qqZSmnaE6CqFGqgcBABJgJEbCGQjANRMwJz5VG8vgMY3EX/1J DgSiZ8dCHjpQG3iyCFyhA75KAsaUUP6ASwEWTSZorJgqBSqwnaxlBWLirxH6ncsmEZ76XuQ5CdTa l31pAStCYNPwg3gVhAPVqsyp/4iU0SQxZ6s2oxryuYQ+UAg6oCTzGmAB5oU9aqyaCCEqkG3EYQWv QqQSup3EwaxiIq1DOQUAcKoKSw3teCTqGGe2ZgEtVAG1IRYwFCNddxTi8BXyaDNWaHNgwGMfe0u0 13aWmFXGWglZQBYfsLIt9rKeumxxRbM1KxGpNBFloAJCACWoCnoGMhvlUh49JjL8JShJ0TeMwAiN sBUk0xVAoAP0UQEAlQASoFQku64IsAfLmLVay7ULACsrZZRDGiajeYpgO6RjMgqgqgJ5ACXZwh7z 6HUW4yfxsSwJ1QR9ogCqCkNTuRN7VjJhYJLlMQGoh0Sjx32LoAQKIk2M27h8oP8GCzARo8qsYjsc l4u5U2AFDUChN2kGSeC5TdVUfeNTgcIem9EZ6NMn++FKCOWtftQkQJQjrUcBVuifY3e7wwoBkMC7 vVsJDxIEEBC82zizAfugr1UcNLu8c9k5XuC8g4KeSLIUhEBTPCV3S2EUHDMB91W0emsgZbcZtUEf sEEfDqADeXS7O3pVWDU87Tue7wu8xksclwuqZfCQx0sROfAXY7A9ZsBONTJDeuIt9AhgMhYj34pQ QgVuZeMkRMsVipgUmVLBYNAkj0oGu5sFB9vBVvC+HXBO84u/czqwTzyzcmEGTVNGYpgDLcyX2XJn /+AiROtbuFUUqJMUKjJTJGD/m+VyJJQyDqchxBPgMXcABupLFu7XwQaxxAohAk48CtDaWs7anXLl nSugxXrgNE9zEl6gAs/LVNHLHo0QFOQaH3hlIPqQFAqgX7iUN+rBVMt1A6cByr0zxx6gAQKBVfeK xwaBAZRkA3xMlPQbsw3QoKV5mtShC0VQBC9gBjuwApz7yI+8IwggRCZTDjyWtCdwtxBTMy0UDaRr MssFFnIwnGDgBrt7AEmsypWQFnvcxxMBK2ZmpKF5k1pMHQbQNCORA16glh/gJ8DcVBNQUDNiMvJz GcvwMTwmFoBVMfzAD+QayrDGLtL1Aet7x9p8FtxsAyzwxxr3zRK6AKZ5muVM/yIAYAbrvAIN0M7v PA4KIGTh4MgPewJNAh60Bm4mlz5JoSMtKQe9kwB3kASnXACpfNAITRZfsNBAE61QLKHj3Dk+zQOd owIXndHu/MjlQK6EcM9+FFAEhQBgsFPL8lOeIsn7kRQVzA86YMRkgc00fSr5ygIbt1JiDcXgGZrd Q6EqoM4NqtHjQM9HTQGa0aUoCYzWAG4t9ADlQQ6JkNJARAF5UMeQ1NU689Uh/JBECqqjuQBPoMU8 gNFEHb1HbWQKMCiMwiQHkjU0M7Hd1wg88mpMpKIK8LEOYF4DIdOCPTj5ygPaSJRyitiz7AVA7QVi y9aSnVQ+qGNj4ye9KQ0WIP8ZlDgEDSMNSYHSyzTQ15zNp30WmPoBPNCaLSW5QOPaFKrOncrWfpKq OaENxWzMWBAN2jA/dS0WdyTcLuLON8CIBG3HyS1FmgAhqj1XIlyUlJbYT+AFTyCzH8C2fdnW270N 6SrcqmsUBYUN/OWbrKbdNwAGGqAGpT3T660zWwshT7Da8D25RboAEH1OGyCb/L3dk/xPniyfo8cs jKFc8XGf+zEBirvVyP3gDRLhQIqhFP7HOQ00owkKfrDhfeLh/f2OrtZ6fdoZ+sAYINrJ+3Fz6Y0z Lq5VWwu/SJpCc3XC7UUJG+DIKc3jTWUB9WjXLXRHiIG67RMGjzYQ7Lvk0/T/vhBwSkk643dK5ZCN 5dEL5DTxcjRHc6S2BkmAG7lxsmYuSXocBGJQBqzJ5phQ5Va+0U0VH7j1IrD4l4D5HjqgBut7bH1+ WRjwviIA5TpT5UWN6JMtEzmUCOzYdaSzkQhgB6dc5pWuVXrsyjg+OIb+aht9I2JTHosUOl23LKOD AG6g5wfA56vO6mTh6km6pKf6udI7KIwRm8nFjtcAQ+NDAkow6cEOkAqxAcRDrZ7rucllCLXYRN9B 6tcQOqZM5g5e7dnFzS/AAoOTs20blS+8Y030PuPj6LB0Aiu+5+iOidwsBewuL6bK7XBWFPYlKAxF 775o0jz3AYGj5PvOjF8t/y85Wx5HAmeMoWNIski77ot3LQGpfu4Pj3s2DQCnYqpRyWoA7CLeMTKA BRCv0wR5vtXAHvKAl9pLqqftUycGP++jzpEEvgYe3/BITPMoy7XNzRvUmj5JqfLu8ywQ4/InYF9C kOr/SPTUGeHMzRtpJoDdYZGAEogu10JsYAExr+9Wz7hYvwC7sfVdz2prJl8u1zA4EPRkMfRn37sR rgZIahZs3z5rEI512ENST/V3j8dNLgZPrkqVkGZN5B1//w112DBjX/a/Xvh4fOlqkeZCufhCoEiP D/l2xRh0jzMtbvnMiPlBQAbndAmM7/fhWEsy9AASAAFkXvWm376t/sqs3//5rj9Dvv8AQqDBlX/7 B83Ke/zqlFAGSdD2a+b7a6AGRzzzxI/7w57pl/ABigSOzT/7BT39p53QbXD92f/3azb1ZFEAHOz9 Xc3NN20J2N8+2v/8x63+6w0CyPrvk/D+4Cj7SQ4IVX6DhIWGh4iJiouMjY6PkJGEKXx8UiyEH01N a2xsQmqVBSCSpaanqKmqfpSWPIOaOGsTal+VWRiruru8vY6tH68fODgSEDaVML7LzM2rMJXBIjhC H6Kkztna24pZ0RAftnwHudzm59refB/IfILo8PG+3kF8BSny+fqpGN64+wADRionsKDBgwgTKlzI sKHDhxAjSpxIsaLFixj/M2rcyLGjx48gQ4ocSbKkyZMoU6pcybKly5cwY5oCQbMRTSuqMNyMRBMb yCqVggotZAWa0AM+CVlRJ+rdIKB8koKo5NTKAaEFnCYqKnRcUqhZCk119xBq10pKC5ythG+S2rPK nlaSSnWQlbdd4yK6u5ZPWz9mfY7VuhBqlZ497b49kAJECqN+FSejWeVtW6h0yfoxmqVx5Uo4D/Ed 1/hx0MtBCxAaXHZuIqN6B7VSvZktUVFyo4qt6+cqn0KGEcE2NDs3b9YOMSdSS9uQUZxqDxxqXE75 at6wy+kEEdoQc+GgAWPFibyhYcQgcllJhqhVlfV8YiOyPgj52EoHYPwV/81+el2ovoVVHkNmdUXK gNe5g+Ah9PlRXgp4ibJfgoTV9x9bb9HEm3l9Hbjhbgp+OJ9rFBaCQRVZRDihgyJaSBZmsy2YUINK 9UccVfDJx0p3DcroB1fj8Bdfexfq5ptvFc5I4iHMEUSIb9DZYwgG+OWWmSBWDVmIb4g0eQiU4ukG X1BJIkQjIcMVUlyYsakTl3vA2eaHKARh8BZ4Wk6CW5jYQKYZh7rttVhpkLVlZ1Of2RMafPfU91Zo Rt3jWICC4kfoaVYOcmiLSgZa6Vr7jYbVfgUKpdemXRXQnSGidvUXfa38SeCSe/np1SEn+lYADKs+ FWFWrNqaRa/BdoVUnP+e9sZpRj05eYoVOymSGCTNymTttdhmq+223Hbr7bfgxrQdsQH5VglB5v5m 4qPIdhjmWtK9ixWvT6K1bniGnKlUusAalK6hXd1oo7xnkVLqUcadVUA5XKoZlI76/hjhw/4K9c59 9hLCVHM/9mTUYTTlch56oY08KW8Na5wag7QWwpln7Ap0ZJBhpvyjKHLm23LEfJpYpbLq2oVzZMgm tWXGYZYZj29GDXLVATZD1UpYLCfbcyINUklz1GzdorPVaCajXbTlds1HlDDY/J1Rzl5NCFQwVCH3 3CUvicHHTiO99rlFJ4JxfisCBCWObKWcIyst0nhwUNgsTmfeQR8O59v/Las5caMFcalWFlBlGfRz g0RXtdEAQm36AXUrDAO6GYPuh+iUg20iiipmjpY3u0qZ8ltzxxw76ZXHfthnqh4dNO9y+85zsTSX /RtUojccK1xfAy97piza45P0feWpb5by2bwPlxgL0rA6px/wXd/sj+gpgPWqi/7p67ttyOOa3imz vUKRwqXW8Qob0bAnPPTUxH5IgpwfAOgcOZmsJziJVGkotT91mSsXXArObfhANQIm7CweZBROMigi +FDNcWRB1Xhspy6jxItLYDKEbwiiuO6pq4YcBBrQiDVDglnMLsIiV7jQMa0hGvGISEyiEpfIxCY6 8YkvGRcjyEZE7sTE/3NNEQ1T7KGVhqEwXmABkVaWghWtfPEjraKYW9aiFy92D4yMK5FsJmajM3rk ZSBI1KLeAgPKWEaBSTNg6qTkoneMpo95/GMgSfYRrmnGKKHakxuvJ6+LYSdnNyPk8jiSHU1FC3Zq Sg8geVag4iEHlJMQpf1E8jf9bFBHMrQX3OZGt9xQijWHW8QsafkekEAoVW3xUfw+2L/c/DIqrBEm MeMIkhOlSCj4UKYOa5Y+1FkpRnWRZunSJ8SOAEk6uVRTdyZptL7NjCzhnASPgucR8MVSXfXT1M/I qQjljIk38Vzgzza5EfwtUH9wK4SbRsnOq/npHQFVmZb4qREJniyH//9E1FuKN80HTss6qHrHprKS KIpa9IAdUWFqupNGe/xlkn0hYKyqQkfM+XAoaAzilKqgK3oN86VB8WACCZErUdh0mTllJUihSNSi GvWoSE2qUpfK1KY69alQjapUp0rVqlr1qljNqla3ytWuevWrYA2rWMcqCaQ5A2O3WkQKlOYSszZj KgWAWobqKStr2etEciOp3FJQDmiFBqRWyOshphJAoNAGA2vtJVf6aBfB2kWVKEGLqIo3PXKI5x2y TM2ECFsItVgBA+kK7FCOqZmrlJMkaAGKMipjvsikCB9Awexv1rMw2hqCs/VyDLC88R5oMNazh4qg NVOCllYcoJe1KQD/5+omW/Eg8iqrwm3esBHYqwgitjdDCgigwVbU3hAvyrgbNC87iNQWbDcBfN3Z RqOW65IFrXUl7mzfI9rf5NFB3pAOdrXm3PoMtnmUUA1vyYvd9cTrsy8xL1IMq6w++lY8o2jaXe4B lPSyKK5Qc4039NNe8WSBO9YNMAYpGRJ7QaZ4oA2KZVPsDnsdk6IJCsqHHUWVII2GOxNti2lfAi2j +fW2xNpOKXTSKyKvBrJkTbKSl8zkJieVB31QASF4sIEqb+AVhdhAH/qwAUJsOcpT3nIZBgEALhNi AX2AwJgJUYY2bLkN5XhCB/rQgQUQQgUQ4PKaMeDmPsBZJE/Is5QH/6HlLw+aEIXuwyDQvOVDF3rQ GJiznf2g5UMPQgR9EMGcu1yGPGtZzX54QpoxLQJC+9nNXQZJog8t6QUsYM2IznQf7KwCWQ+6DHSm MyFE3QE/QLnUhWiArjGwZT/UGgB+KLOU3fwEP2C6AX4odrQVDRI/K1tTdG7ApA2h5Wu7+drGjrKW t+1mFcwZ2oYoA7SJDQE/uNnOaG6DH/I8iFpLWcsNEHaqP0JrMPuB0VsWAaxNLWp5Q0AE9h7EnMsA ZWQPotNbdngirj3uf5tZ2gkvw5zp3LaOJDzcHVABpuWd5VmLAALCBkDCRV1qYveBILXuQMcHwYJM mxreF6d2wsvchv9vj+TjfmhALlzO7VmXucxP2PmXv4xli+/7EEcvR8XR3GWMRxnXwH62SD5e61ew u+gLEHWeMWBvl1uZ1Gc2MyJqjYk7gznh+Hb3rNEM7IqH5ONQhoDI+yDxm7u81PauNckV3gd0Ux0R uF66ooWt9zxDu9YiKHO7MSDoWrd76/5O9pc34KyKYxrZ9sZ0swlx9EWr3RC1Vny9DU2IPkNg9AvI c5q3fZIyvLogth940BfgLFc7+ffAD77wS9IKIWI3FdudriLcWtYyqsJeO2Z+NnbKsu4ywsCDSFs3 ofb8cWQ4vpGAvpEsrA3aEnISw3uvT6A19LX+hf1z8woG2C8bxzr/CBs1WateqyDk+0UOX4GFXAuU WPvHX8pyIPhHCvrHU+6nFFZUCrG1Y9mXGmQBXaGzXnjxQuOwgYyzY/9SXuqCH0GBE6MhPnMSNLUB W5q1QKElMUOjfPzDgWfjgvsEfo3gWZQQF7RlBXwhCDmIOGHBXX7gDfhwFRxVYelhWpy1HlQTg60l CAPWNP4XJ+9hD/MnJRAChWSxYbVhQbrhhMoiCEJIhKzAGKVACdKhNSKjJUJoJ6oBDfigFpSRQ1cR TFsTFfABOIQQg3IhCHxjgIWANLGlWjRhgT9CU2Txh+JHCnxIXnKYRxB1CrYSGcd3fNAwYSCIMBKI WztGWvHSiNiV/zFuhTRweDA4hjN+GDSLeIIg2IcniDCnAECmEySqNYGGtIHvoBbqERqbeIfc0RhW 8EuMGII3RBaelT2HkDF8IVpxgQ0Dhl3HCB8wSIyuqIs/0k2OABQdpF48yBaTs0MT2EdyeIAWMgpZ oiH38Es4AYovwkUmiB/fhyUFQGFBsmG/JIZe0TDRR43k5VsgMI7HBwl16DJDMhtCKBuRyGJaIoFA g4gKOF6sGJGWaFKjeBR/8WLkwTtBwmJQMY2tSF4KGRcBuQvQAgk/Ji3ltB0z1x58pU8o6Aj950nE 8oCocJItAQ3HdRXbGFZ3w0crOXxAGZRC2RAN8GmHxgObhm4ld/96rDcIUNYHa1Zm+4ZmoMZmffZn oTZndXZnnrZnV/mTF0FqedZsYvdpnfdlptdoseZvkTZrpmZpzpZpm+YHEPdpYyZ2aEdpp3Z6HSFs pVZwcvcKQGdqmNZvmHZrudZrg8BrvmZzwTZsxXZsmrdsfdBsWidt0uYRH5dmeolzg2dq3sZ3/mZv did35lZ4h6BuC8SZ72ZxBqdzYIZv+gYSm6loUrkAWvZ0egmYB/dxC9dwbCZ7fQd1semWh2d1UqZx WyZztOlvxdaWacaXnXlyKbdyNudyMMdxilBmdWecObd6UsZzPvcRtakpKqACUPaZnXl0lal0itd0 h5cINQcAUuf/nVUHmyqAdZeGmh4Rb0FnZmWgAnYGZXA5bmL3cmW3ZWfnmE6XCJLpdlIGd6j5bnR3 cyCRZwBwmKGWZngGlWD3d+F2nn5WCOdmerr5cIq3eBzqeOEWeZxJeVFmeSERewpKelsGAU0Xa3b2 eSEqeoVQeg16CKm3dKunloPgerAnexBAex6BAQuglIOgbWB5DrlnCFJqCL43lFq6pVzapV76pWAa pmI6pmRapmZ6pmiapmq6pmzapm76pnAap3I6p3TaVVa2AW3ApI2wAQ73BFDKCFT2p47gp762AVBa lDkaEmlWZWMZCWZWa3qqCIEqCZAabrSHqCWhdpSnmA0AAHya/wsB2qkbMGgN0AZl0G3bFqqe6qc9 B20LkJ+FyqdTsEAqUGWWdqp896pRtqp0KaD/1gZ4KqgZcXpl1gCdhnAHZ3EQkKF9wAMYIAL5Nmci AJ9pBgBaWWa9BqnpKZWaBwDlRggNIK08YHkd6qRXl2l4BgFTKhGnB6llNmZQxgNohmxoZmmVmnag 16x6aamC9wS8p5cAkKVu12+COXdRRnfyqnsa0a6zpmWmJ6BgVq+FcK8Pa6n7CqnP+mXI1gBKmqOV +rEGG56bt64RcXonJ3e5IGoQK2USO7CFILGV6rCV+qR7x3va1qET65Yg62pglm888K0dQWfn2W0b GrAnZ64sm/95IaqUMOuWMmt0uaplZYBpPCBnigmeDbCz9SpqG7AAZZaow/plITdl0uqqEau0ynlo TWtnT8t7AJBnHfAKbRZwUJq2Wvt2c7asdbq3fNu3SNUAo/cIkwq4jUC4pYCp2CJscAmohqq4jOC4 pdCyE4EBngoA6CagtTpor1qqbYBulMunl+u1wMplPBCgdma6xvaqsvpv+SmVPDCuD+erZEa6C1S5 f7q5rWpxyempnftwlbtmCwCsYAsPJydyoJZmPfd2QgsB6upsendyYxadstYBAXu2Uoa8PgepmEa9 tfZ4/BmX1Ou8xjtwMZeuSOtsIQcBvUZ5jddr+gZu8hCvdMn/d9GmmB2Qrfoar/KLa8i2ZWabtABc v4PwqCE7v8imaS8LZvtLv273CvEqsRhge3PWmK+wAM5aZrmAwPlwrxeXam2ruxxcdakmsSQMZmpH wDw7aCwgAsRmaWs7wE83swcLZmUWnRa7lmi5wZW5mvLmmCdba2QZoztMbD08wtaru9GWaijcsgTq oWkXoUM8om4XxCsrbPL2tM1mwXz2cgFxrF7rlo0mmZC3AJhWBl5cZnamdvH2pJlGxiasxF0GqWu8 QMwLbGmXp2fslm4nAm5se1FmxaKmaFi3AB2grg0XaOoJDw2wvViWabmZC8fGvFi2yHTWyPumZfIm edd2wnHs/7RS/LWHgMlBx8iox3eSjMTYisZZmW31lmfQihDSSbHwUHMkK6R6rKi6KcvmUJQMbAq6 rJmJ+qoKuw0BOryQIMx+m8xpyqeJgLjZMKnhwsyIILnO8MsbAbu9ameiSp/Z3M0C6q2whp5RWrm5 MK+8mghl4KkqUM4qwLmA+6mpm7mrZ2efa7msu2binM6jys5Fubj70L3hZqy9mawlfL2yVwgAOtCl xmjMGqmRRr0Q0MkhN2puhgnYq7w7+rxq5riK+9Bv28mCdhD8i76aB6/NWtDT9qdm9q4UPK/zm8iN 2WzvCsR6Gb1VZ7/4a8H6OtIdUGrvCmUyDZWCpxBtwMLF+f+wKC2dSbyvutuySh1uS6erbEttHWxq /KrHBPysmDCkWybVCtHEY+ZmKTvDAazUZibWGwqxyEbEa7fDLuuwS+3D7QapNM3WuNZ14Ra4N4wQ 7Atsoma06uqXbny9J2pmf03G6kqVTwDK0oyifKxpZOfJMDxtIpqvr3ZwXzxpGzB28/vYMmfNAgHK Tlm2s7usb3wIaoeUmWa2b8vA0ilnlWyxcH1xIvDIFkvJcRtmEgfbuQ3aAUHLq0BsJ7oIpZoKT70I QF0RvDycpsBo/pwIzyqskHDcibDZVzsRxawLZLfO6CDOkHCetazMc+rM0D1ojQ0QZLcS1IwIEU1o zJ0P7U3/Eaq6Aazau7E6aN/cBgQaau38q1fWmGMrzrhL31EKrK8aqXSpzpCMZcJMdnw6ZvMtZVA2 tsFGzr1aqu8dD1RprXSGrUXrZq8gvfUKnO+7q4u61OWbZ2XAvh3qzx7d3pt9pOraBstayOa6rFQr eU93rHi20NE53BpOv3gN18aacP7rmmqHwSTNyeFWsDrtwEobZkHNcJVJbAAw0qImr/QrsdLJ0g+s nQLxwg4brtFJ2GnJwIlWbEy+szLsz1ztlhDQBt0LcI2W1LoJ1/W63vsg5ormZtp22hbnonaG1l4G xxZL1zussm2t18kW0e7by0jM5bqJ1iqr5/rA53L3BN+q/8ZRRnlddshxXr/NhsKWOsgaet6mzpyM N2iFvNhLmtQdoNeHfbSWng+YTubWKsIVK78d+soySuqVygN5tum6ydtNV8ZR+mn0esQyWgiq/cq1 DhMBepc9C9Nbxb6brWbRPVYBep7DLN7gHu4Fkd7ObqiM8LnWXriMjgjofi3xPWXmvgiC99yPG+Vt LeeRELyrO+DNFuF3hqewB6vC7O+0iqeTps/cjbud+wSr6+BXfuHqDOAunJ8E/3CourmjamwAv2jt DKxB/d8Tu/G4GrCQ0Gl8KuTLC5UbTrXdymyHbrA4rq/dVsYvLtGWJwI+R+PWmtjVmuMnPrArr69R Kq6WZ//i3rrDKQ6V29t3R8dsZD6tkWDGXNvklurS9TrSfnC/L8+zy56f9DvtyT3TOyy1SYzlJ73l gA70aG+vOjuiWK/1eC3HaMvAcH/LMPlpwF7Aee5vHyz3AEzNb+7Vs921ireySBzLeq+0O4vEF9v2 KZzA5q1ovt3WZn63AJxylzbXjl/QmD/tNP3WVG2okG7npfz4gO/4/+lwP7z5Sov5zrvXjhB4eW/6 YHZySae8ABBoiS9lrf5uqR7ZUz3Zrf62tH+9sZ6zxY/8N2z7CXe3eVoIzI/RA5GbNA78VX/EW6y3 C6Rl1Lv7QfdpWGbssh3631+tka68lzfPKO2y95r9Drf/+KLMU26m/ZMv7vZ///ivC9B8CucNCH6C gg1Pg4eIiYqCTw2LhwAbhw0bPI+XmJmam4MqfQucihsAiw19KqGXnqCYG32TlamYGJEAjn4qlriW CyqUqIK9vxgqo2XBbaNTjKMAn35lkSoYfsIbKgvJbbedvL7Jhs6x0dfU1tPFAMd+PBvKWq4AoNmx gsXFr4Nl2Ow8TxvbZA0SAUEFwWN9JPlJiKsPhFOdHJ5qAwFABwgYykAY1YfUgj4inH3C0KEDgI0N H3oSoQICxkMMPXVo2aeMiD4mSZpE6UklRYsYefRpI65BB5A8THFE5alNmz75gkHcACEkToHs+lgq 03Gh/8KYQxE1hdb1iVZoZcxKenrM2QKh4WqO/SiCx4J1g8BaWvURFVw/zvaF5UrKLI+mTxZQWwW4 DzURHfxAiOzn6KG+flwdc4WVsdfPnz1HnAe19DRXDyVxbtirNNTWrEQmpJZXEmO+ED25hl3N9SkM N6GSYuzKNejVUlGtRp7KkyEMYRmGfnaIsSlSEVExfErNrfPq1Bs04PEUmCCwoHAz7WNotJ/riBY0 MPiJMfdDVQXdvDw1H/NQGomwgFuSQfCEOKyJRd1FB0LQmgqeSCIUAE88dBdIC0BGzDNqDXhWbQni 1saFAmroGYMneSiPZp74MmGFbTQGIVT8KedfVLI0cP9TB7rw8FAbIthGnXvvoUYKBq4A9JIzFXF4 FI8J4nJURYigl6ArMT7x5F7hGekHLQ9BWcZRTD0kgiNI4vRUjZndiNWbcMYp55x01mnnnXjmqeee fPbp55+ABirooIQWaiigxGjSDjeHLCpnJHeOciieKGXiaCKivQmpndJN+sg+DUTSiFO3tHNNVjN9 mc4xoBLVyzH0ALAMY6bKikity1STzDTsAENPj/4AdAs9vLIDECudeqrIRxU96UxkZgHwFA9MrtUs RswmtIpGHA33iVBEJQsugnQ5QwpnSjmjXFXP9maVt5E800GMyi7ykbeWrNaAYNpJQpgfhn3UwWLP lJH/FnqIKQZeG4l1VxM7hnDmzGORadZmY8f4U5kIX3Z1ar3L5vYMulNCxNBHrmEDEWtppsZycF0N Alxp5+J4cXGlXXyzzb6pZh7IbBL3ylMNYMYQfINgxlqL080z302sBPP0J/dpzNl9gyw3tGMQS8Zx dVEDnbTIoFzNXnkLdWAIig4qvUqLEbJm7gIWCzK3Zi8yxNmLEMSodVYUMqQu05KKHfTIrxjVUQdC QlCkQx6tvEqaSm6o2Ek46SIImJnbkxo1q9F0ps6hf/4lC1C1QU2yhrfu+uuwxy777LTXbvvtuOeu ++689+7778AHL/zwxBdv/PHIJ6/88sw37/zz0Ecv//301Fdv/fXYEwoCCFYUv333wFdRAB/kZ0Eb +YKgvwgIfBzwyAF8gDAI/PLLyT75+LcvCAz5HwD+IVXIH/nkpz7ypWAQBcxfAarQpwAWAAYwGJ/7 /KC+A0xQEey7YCLoN7/4zckKFoRfASwIAz/w74FVEGH9BuHAEPqPgnxIHx8KcL4YwjCE5GOgnqww Q/BZoQAF6J76tjcIK1ShCuDL4JeIeAgOCsKJGEhBFQ4oCCuAAANTFIQUU0CbRChREOyjIQv1B0A+ 6PAQCeRDCWEowyKS7393SoEaD/G/BO4vfwdUIvzO+EQP9lF+P8TfBOFHSD/Aj3xBxCAZTWhGRIwP jv8B5GMbYThANlryjlTEUyQXYUce0jCMfsgg/9bYRAFWkn8MzAIfDijCKcoxC34IICkP8UVD+rGD K4ylACeYwAC6z45jlGSdNqkIOxKzfmGcoSIIGcLxyc+ZIAggLOFHRVVWYXvK9OIinYjLMo6QhJMk HwbGF0Abqk8QxMTTK5uYBSGaM4bpBCMeN3hLDprSfU48ZP4UeUFUOpIPkGwkIuyYzHcegn+ZvNM4 /ejAcMZQjmuEoBV7CMQu/rGb46OGFcDnRFUeEANwpOUiw/g/XyIing4VhCqB6YdAhtROcmzfIalo x3EWQIrKVCJKucnBUYLAmbasnxwPAAJr8vMQqkT/4SFDilJLqi+Q78ShQPdUVPIdIJPATMH4ehhK /dkUjjz1IAb0uUZu8s+qFh1ELfe3Va6edKoINCg602jVhAKNiR/k3iWs+FJNfC97gA2sYAdL2MI+ gq+EQqxhD6FV/N00rmiEpynhesgL4k+HjUUkVgVoPhkKUH5rLV5MYVCFs9LUhm1MgQXH982E6lOe OfTDaEtrQBk2k4xWdWH3Qju8hf7Pk9Q45yV1KUxbctCXZvStG8V4TgywVKQaJN46kbrK4Qq3qbb0 pypROd1BePSSoByuG2dJPJRuUrjXhWsH1znCSJq3kZM9bf8QWNzgvZeB6EUtcZcZvwMEUY3uVe95 vdvH2jrKFJzpqy/wuqvS6ua3jMWl3yhXGUkG++G76BvrHCe5Qbv2dnyZDCM1gNrSbM41wvGTY0Yj udAQzzC4Ngxk/YRLx7SWl3ykPasOT0ja8c0Su/Rzrv42Wc4cx/aSDb2hC/O4yONldoaZxMBK0Qph /soPfiUk5pMfy2Fb4teUDOSt8RSLCAz8FU9kXqya18zmNrv5zXCOs5znTOc62/nOeM6znvfM5z77 +c+ADrSgB03oQhv60IhONPACAQAh+QQFAAB/ACwDAEgAmACcAAAH/4B/goOEhYaHiImKi4x/fo2Q kZKTlJWWkX6ZmpmXnZ6foKCbmxijoaeoqZ+jmgsAG4IsT6yqtba3jqx+DSptfy2GYgANtLjGx5C6 flo8LB2wjB0qWsXI1si6GE/OaZYbPKWb1+Opyk8AIoIEhU6VstXk8Zi6rhtKt8LEpvL8hsq8bZRs uSaN2r5+5HQxY3EE4Z9v4TQ5NJbtXIdG7a69OzhxFT10kgh0iZcPXsd5rBq8ungSUpqCJlsW+ter ocxJdZaIgchRpsJm6f6MvNlJzEZxEysCYElUVYdhMY8pcxV00ICmtTaImBYV1b9XWPm1AdfTY8qa YSceOSrxkrKFNv/TyhQBtSyjUdqWxpWLdatBpI0ynavKt7CgsRE5LcqEwbDjQgDWzrI7KBO0x5gF HakLmFAmAJlDD/ILLxMP0aIzHCaLNFMD1LD/uFBytPKj2Lj/6BNkOTfsDYpzgfYtGkBw08RF8zi+ K3log55vO3c8IzhvP5en8wUu/fpw7XxVWM91GjzfBeNdm+cbzl/39UQ7jL+eHb5MFvOF228q/v31 8vvJhJ5/ubwWoE8EXndgS9wl0tuCExmXoH4QOrTchMhViBB0iKinIT8i5Bfdh/w0qIhlZZBIjoSL +fGditYM2GJ5U8CITHsnNmcjMvJNGB1TO96Cn4+21RdkKnb0F5j/i0fiIuNdfgDYpCoiumfglKmY uCSWqrCYDHZccHnKhfO8KKYnHC4p5ZmXqFHlIR6y2Ukbb8JJpJyMeDlPN3ha8mSZfVqC4zxrBsqI ESHeaaWhkwxZSSZiMBqJkpQ8KCkju1XK5KVQWpIhp4loOUmcoB6ip6ZAlkrIZG5hp+ohaWpq5qtk 1NniE68WQqeiDi6TKyGUtkrYq3966uqvfwxq7KygJuoRrr866kkmWiAbbCeZkPFrptMe+6qtXzIr qajY+gGtqqeWq4Uar7IaSibsqhprt0YyqgS486ig6q5emYsuvl9Wy+kQfxQrih/aXspAsgB/WW+f zpaz6aXS9nuu/6TXvusrp9z2C2rDknx2KbmnaMKCpOn268fJhrpriyZoGDovlX5gMKyYYoBsrM14 VkxRzTc32R+vB2OQqo13ZCDGgERr3MBFNQa5QUTxaPL0kRLqrPEuQUPYwWRN19IKjCL81ZEmhR6Y ddi4oF2hGmAT5faBZbclt8j7rZ2WyX9ErR3cdu+dCcva1a01P3zXnJzej2nStWgQxB0aY49jJoI+ bCPIc2wsUB0bYw8XpsaFmWPl2j2ZXR54bq4dLVfnq7PeumFkkG6e1Rv43Rfm8M0dFuyHY+b7TUfY fuDwJ6kePGqa6NsS8KXjxvdEMwwN4/T9HMG7jdjH04bnO2riS5E8Q0cPHuXjkLE9lugj833sTbaP S/l4yq+K+vCLObsq7y9fodWu6wT9JGW1yklCDOu71Ng+MbX8GQp5lGDctz41CSUwDVnXiRIlGug/ LmlCXIgYIAZts7JGLM2ByOreIThovgcODhEzkOAIO5SJm1kQhTO0zeYEwcIcfmlzMvRhi4wmOSHO A3xG/BIOk9gh+AQCACH5BAUAAH8ALAAAAAABAAEAAAcDgH+BACH5BAUsAX8ALAAAAAABAAEAAAcD gH+BADs= ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/includes/header/03/style/header.css BODY { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = BACKGROUND: url(/common/includes/header/03/images/bg_body.gif) #fff = repeat-y 50% 0px; PADDING-BOTTOM: 0px! important; MARGIN: 0px; = PADDING-TOP: 0px! important } #constrain { MARGIN-TOP: 0px! important; BACKGROUND: = url(/common/includes/header/03/images/bg_constrain.gif) #fff repeat-y = 50% 0px; PADDING-BOTTOM: 1px! important } #hdr { BORDER-BOTTOM: #fff 15px solid } #hdr .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 4px; PADDING-TOP: 0px } #hdr .publications-search { FLOAT: left; WIDTH: 100% } #hdr .publications { FLOAT: left; WIDTH: 100% } #hdr .publications UL { PADDING-RIGHT: 0px; MIN-WIDTH: 24em; PADDING-LEFT: 0px; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none } #hdr .publications A { FONT-WEIGHT: bold; FONT-SIZE: 70% } #hdr .publications A:link { COLOR: #313131 } #hdr .publications A:visited { COLOR: #313131 } #hdr .publications A:hover { COLOR: #ce0808 } #hdr .publications LI { PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/bg_publications_links.gif) = no-repeat 0px 1.5ex; FLOAT: left; PADDING-BOTTOM: 2px; MARGIN-RIGHT: = 1.5em; PADDING-TOP: 3px } #hdr .publications LI.li1 { PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/bg_publications_links.gif) = no-repeat 0px 1.5ex; FLOAT: right; MARGIN-LEFT: 1.5em; MARGIN-RIGHT: = 0px; PADDING-TOP: 5px } #hdr .publications LI.li2 { PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/bg_publications_links.gif) = no-repeat 0px 1.5ex; FLOAT: right; MARGIN-LEFT: 1.5em; MARGIN-RIGHT: = 0px; PADDING-TOP: 5px } #hdr .jumplink { DISPLAY: none } #hdr LI.nature-link { PADDING-LEFT: 25px; BACKGROUND: = url(/common/includes/header/03/images/bg_nature_home.gif) no-repeat 0px = 5px } #hdr .nature-link A { PADDING-LEFT: 0px; FONT-SIZE: 100%; BACKGROUND: = url(/common/includes/header/03/images/nature.com.underline.gif) = no-repeat 0px 90%; FONT-FAMILY: Garamond,serif; TEXT-DECORATION: none } #hdr .nature-link A:link { COLOR: #ce0808 } #hdr .nature-link A:visited { COLOR: #ce0808 } #hdr .search { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 70%; Z-INDEX: 1; = RIGHT: 0px; BACKGROUND: = url(/common/includes/header/03/images/bg_search.png) no-repeat left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; BOTTOM: 0px; PADDING-TOP: = 6px; POSITION: absolute; TEXT-ALIGN: right } #hdr .search A { COLOR: #fff } #hdr .search LABEL { FONT-WEIGHT: bold } #hdr .search SELECT { FONT-SIZE: 85.4% } #hdr .search INPUT { FONT-SIZE: 85.4% } #hdr .button { BACKGROUND: #f9f9f9; COLOR: #000 } #hdr .leaderboard-links { CLEAR: both; PADDING-RIGHT: 208px } #hdr .leaderboard { MIN-HEIGHT: 93px; BACKGROUND: = url(/common/includes/header/images/backgrounds/01/leaderboard.gif) = no-repeat left top; FLOAT: left; OVERFLOW: hidden; WIDTH: 100% } #hdr .leaderboard .padder { MARGIN-LEFT: 15px; OVERFLOW: hidden; WIDTH: 728px; MARGIN-RIGHT: 15px } #hdr .user-services { FLOAT: right; WIDTH: 208px; MARGIN-RIGHT: -208px } #hdr .user-services .list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 3px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #hdr .user-services LI { BORDER-RIGHT: #a8a8a8 1px solid; BORDER-TOP: #e5e5e5 1px solid; = BACKGROUND: url(/common/includes/header/03/images/bg_user_services.gif) = #efecef repeat-x left top; MARGIN-BOTTOM: 2px; BORDER-LEFT: #cecece 1px = solid; BORDER-BOTTOM: #a1a1a1 1px solid } #hdr .user-services .us-link A:link { PADDING-RIGHT: 2px; DISPLAY: block; PADDING-LEFT: 37px; FONT-WEIGHT: = bold; FONT-SIZE: 70%; PADDING-BOTTOM: 4px; PADDING-TOP: 3px; = BACKGROUND-REPEAT: no-repeat } #hdr .user-services .us-link A:visited { PADDING-RIGHT: 2px; DISPLAY: block; PADDING-LEFT: 37px; FONT-WEIGHT: = bold; FONT-SIZE: 70%; PADDING-BOTTOM: 4px; PADDING-TOP: 3px; = BACKGROUND-REPEAT: no-repeat } #hdr .user-services .li1 A { BACKGROUND-POSITION: 10px 0.3ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_account_red_med.gif) } #hdr .user-services .li2 A { BACKGROUND-POSITION: 10px 0.9ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_ealert_red_med.gif) } #hdr .user-services .li3 A { BACKGROUND-POSITION: 10px 0.3ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_register_red_med.gif) } #hdr .user-services .li4 A { BACKGROUND-POSITION: 10px 0.5ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_subscribe_red_med.gif) } #hdr .user-services IMG.usi { BORDER-TOP-WIDTH: 0px; PADDING-LEFT: 5px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr .user-services .ad203x90 { BORDER-TOP-WIDTH: 0px; PADDING-LEFT: 5px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr #header-nav { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; LEFT: 10px; PADDING-BOTTOM: 0px; = MARGIN: 0px; BOTTOM: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = POSITION: absolute } #hdr #header-nav LI { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/tab_l.gif) no-repeat left top; = FLOAT: left; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #hdr #header-nav LI.hilite { BACKGROUND-IMAGE: = url(/common/includes/header/03/images/tab_l_hilite.gif) } #hdr #header-nav A { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; BACKGROUND: url(/common/includes/header/03/images/tab_r.gif) = no-repeat right top; FLOAT: left; PADDING-BOTTOM: 6px; PADDING-TOP: 6px; = TEXT-DECORATION: none } #hdr #header-nav .hilite A { BACKGROUND-IMAGE: = url(/common/includes/header/03/images/tab_r_hilite.gif) } #hdr #header-nav A:link { COLOR: #ce0808 } #hdr #header-nav A:visited { COLOR: #ce0808 } #hdr #header-nav .hilite A:link { COLOR: #fff } #hdr #header-nav .hilite A:visited { COLOR: #fff } #hdr .journal-header IMG { BORDER-TOP-WIDTH: 0px; DISPLAY: none! important; BORDER-LEFT-WIDTH: = 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr .journal-header-image { BORDER-TOP-WIDTH: 0px; DISPLAY: none! important; BORDER-LEFT-WIDTH: = 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr .journal-header { LEFT: 0px; WIDTH: 60%; POSITION: absolute; TOP: 15px; HEIGHT: 74px! = important } #hdr .login-nav { CLEAR: both; PADDING-RIGHT: 10px; BACKGROUND-POSITION: left top; = PADDING-LEFT: 10px; MIN-HEIGHT: 124px; PADDING-BOTTOM: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: #7e7e7e 1px solid; BACKGROUND-REPEAT: no-repeat; = POSITION: relative; BACKGROUND-COLOR: #666 } #hdr .logon { RIGHT: 10px; POSITION: absolute; TOP: 0px; TEXT-ALIGN: right } #hdr .links-above.logon { TOP: 2.5ex } #hdr .logon A { PADDING-RIGHT: 0px; BACKGROUND-POSITION: left 0.3ex; PADDING-LEFT: = 18px; FONT-WEIGHT: bold; PADDING-BOTTOM: 1px; COLOR: #fff; LINE-HEIGHT: = 1.3; PADDING-TOP: 1px; BACKGROUND-REPEAT: no-repeat } #hdr .logon A.login { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_logout.gif) } #hdr .logon A.login:hover { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_login.gif) } #hdr .logon A.login:active { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_login.gif) } #hdr .logon A.logoff { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_login.gif) } #hdr .logon A.logoff:hover { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_logout.gif) } #hdr .logon A.logoff:active { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_logout.gif) } #hdr .logon P { FONT-SIZE: 80%; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 8px } #hdr .logon .user { FONT-WEIGHT: bold } #hdr .logon .inst { FONT-WEIGHT: bold } #hdr .login-nav .list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 70%; RIGHT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; POSITION: absolute } #hdr .login-nav .list LI { FLOAT: right } #hdr .login-nav .list A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; FONT-WEIGHT: = bold; BACKGROUND: = url(/common/includes/header/03/images/bg_register_list.png) no-repeat = left bottom; PADDING-BOTTOM: 6px; COLOR: #fff; PADDING-TOP: 4px } #hdr .login-nav .list A:hover { BACKGROUND-IMAGE: = url(/common/includes/header/03/images/bg_register_list_hover.png) } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/includes/footer/03/style/footer.css #ftr { BORDER-TOP-WIDTH: 0px; CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 20px 0px; PADDING-TOP: = 0px } #ftr #footer-journal { PADDING-RIGHT: 1%; BORDER-TOP: #000 1px solid; PADDING-LEFT: 1%; = BACKGROUND: #eee; PADDING-BOTTOM: 2px; PADDING-TOP: 2px } #ftr #footer-journal:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } #ftr #footer-journal P { PADDING-RIGHT: 1em; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 1em 0px 0px; PADDING-TOP: 0px } #ftr #footer-journal P.journal-name { FONT-WEIGHT: bold; FONT-SIZE: 100%; FONT-STYLE: italic } #ftr #footer-journal P.issn { FONT-SIZE: 100% } #ftr #footer-journal P.eissn { FONT-SIZE: 100% } #ftr #footer-journal P.extra { FONT-SIZE: 100% } #ftr #footer-links { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: #000; PADDING-BOTTOM: = 5px; PADDING-TOP: 5px } #ftr #footer-links UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #ftr #footer-links UL LI { DISPLAY: inline } #ftr #footer-links UL LI A:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #ftr #footer-links UL LI A:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #ftr #footer-links UL LI A:hover { TEXT-DECORATION: underline } #ftr #footer-links UL LI A.about-npg:link { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #ftr #footer-links UL LI A.about-npg:visited { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #ftr #footer-copyright { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left! important } #ftr #footer-copyright A { COLOR: #db1a21 } #ftr #footer-copyright P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 5px } #ftr #footer-copyright P.logo { PADDING-RIGHT: 36px; PADDING-LEFT: 36px; BACKGROUND: = url(/common/images/npg_logo.gif) no-repeat 0px 50%; PADDING-BOTTOM: 7px; = MARGIN: 5px 0px 0px; PADDING-TOP: 7px } #ftr #footer-copyright P A:link { FONT-WEIGHT: bold; TEXT-DECORATION: none } #ftr #footer-copyright P A:visited { FONT-WEIGHT: bold; TEXT-DECORATION: none } #ftr #footer-copyright P A.footer-copyright:link { FONT-WEIGHT: normal; COLOR: #000 } #ftr #footer-copyright P A.footer-copyright:visited { FONT-WEIGHT: normal; COLOR: #000 } #ftr #footer-copyright P A:hover { TEXT-DECORATION: underline } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/layout.css #header { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #breadcrumb { MARGIN-LEFT: 1%; MARGIN-RIGHT: 1% } #constrain { FLOAT: left } #constrain DIV.constrain { FLOAT: left } #constrain { FLOAT: none } #constrain DIV.constrain { FLOAT: none } #content-journalnav { BORDER-TOP: #fff 1px solid; DISPLAY: inline; FLOAT: left; MARGIN-LEFT: = 1%; WIDTH: 79% } #content-journalnav:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #content-journalnav { HEIGHT: 1% } #journalnav { FLOAT: left; WIDTH: 21% } #journalnav:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #journalnav { HEIGHT: 1% } #content { FLOAT: right; PADDING-BOTTOM: 1em; WIDTH: 76% } #content:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #content { HEIGHT: 1% } #extranav { BORDER-TOP: #fff 1px solid; DISPLAY: inline; FLOAT: right; WIDTH: 17%; = MARGIN-RIGHT: 1% } #extranav:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #extranav { HEIGHT: 1% } #footer { CLEAR: both; PADDING-RIGHT: 1%; BORDER-TOP: black 4px solid; = PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #footer-copyright { CLEAR: both; PADDING-RIGHT: 1%; BORDER-TOP: black 1px solid; = PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #footer-sponsor { CLEAR: both; PADDING-RIGHT: 1%; BORDER-TOP: black 1px solid; = PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: = center } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/reviews/style/layout.css #content-journalnav { WIDTH: 76% } * HTML #content-journalnav { WIDTH: 75% } #journalnav { WIDTH: 23% } #content { MARGIN-BOTTOM: 20px; WIDTH: 73% } * HTML #breadcrumb { MARGIN-LEFT: 1%; MARGIN-RIGHT: 1% } #extranav { WIDTH: 21% } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/main.css * HTML BODY { FONT-SIZE: 90% } * HTML BODY { FONT-SIZE: 89% } BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; BACKGROUND: = #fff; PADDING-BOTTOM: 20px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 0px; = FONT-FAMILY: Verdana, arial, Helvetica, sans-serif } A:link { COLOR: #36c } A:visited { COLOR: #639 } A:hover { COLOR: #c03 } .print-header { DISPLAY: none } .hidden { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } .clearfix:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML .clearfix { HEIGHT: 1% } DIV.cleardiv { CLEAR: both; PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! = important; PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } SPAN.cleardiv { CLEAR: both! important; PADDING-RIGHT: 0px! important; DISPLAY: block! = important; PADDING-LEFT: 0px! important; PADDING-BOTTOM: 0px! important; = MARGIN: 0px; PADDING-TOP: 0px! important } .no-css { DISPLAY: none; HEIGHT: 0px } #npglogo { MARGIN-LEFT: -34px; POSITION: relative; TOP: -10px } #npglogo { DISPLAY: block } HTML > BODY #npglogo { DISPLAY: none } HEAD:first-child + BODY #npglogo { DISPLAY: block } #npglogo IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; Z-INDEX: 1; = BORDER-BOTTOM-WIDTH: 0px; WIDTH: 26px; POSITION: absolute; TOP: 1em; = HEIGHT: 26px; BORDER-RIGHT-WIDTH: 0px } #accessibility-bar #npglogo A { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; = BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .button { FONT-WEIGHT: bold; FONT-SIZE: 80%; COLOR: #fff; BACKGROUND-COLOR: #000 } .clear { CLEAR: both } .clearleft { CLEAR: left } OL.decimal { LIST-STYLE-TYPE: decimal } OL.decimal-leading-zero { =09 } OL.lower-alpha { LIST-STYLE-TYPE: lower-alpha } OL.upper-alpha { LIST-STYLE-TYPE: upper-alpha } OL.lower-roman { LIST-STYLE-TYPE: lower-roman } OL.upper-roman { LIST-STYLE-TYPE: upper-roman } OL.lower-greek { =09 } .align-left { TEXT-ALIGN: left } .align-center { TEXT-ALIGN: center } .align-right { TEXT-ALIGN: right } .align-baseline { VERTICAL-ALIGN: baseline } .align-sub { VERTICAL-ALIGN: sub } .align-super { VERTICAL-ALIGN: super } .align-text-top { VERTICAL-ALIGN: text-top } .align-middle { VERTICAL-ALIGN: middle } .align-bottom { VERTICAL-ALIGN: bottom } .align-text-bottom { VERTICAL-ALIGN: text-bottom } A.seealso { MARGIN-TOP: 1em; DISPLAY: block; FONT-SIZE: 70%; TEXT-DECORATION: none } A.seealso SPAN.see { FONT-WEIGHT: bold; COLOR: #c03 } A.seealso SPAN.link { TEXT-DECORATION: underline } A.rss { PADDING-LEFT: 24px; BACKGROUND: url(/common/images/icons/rss.gif) = no-repeat left center } A.rss:hover { BACKGROUND: url(/common/images/icons/rss.gif) no-repeat left center } #extranav A.rss { PADDING-LEFT: 22px; BACKGROUND: url(/common/images/icons/newsfeeds.gif) = no-repeat left center; PADDING-BOTTOM: 2px; PADDING-TOP: 1px } #extranav A.receive { PADDING-LEFT: 22px; BACKGROUND: url(/common/images/icons/newsfeeds.gif) = no-repeat left center; PADDING-BOTTOM: 2px; PADDING-TOP: 1px } #content SPAN.free { COLOR: #c03; TEXT-DECORATION: none } .dev-error { FONT-WEIGHT: bold; FONT-SIZE: 80%; BACKGROUND: #f00; COLOR: #fff } .b { FONT-WEIGHT: bold } .i { FONT-STYLE: italic } .latin { FONT-STYLE: italic } H1.page-header { FONT-WEIGHT: bold; FONT-SIZE: 140%; PADDING-BOTTOM: 4px; MARGIN: 15px = 0px 10px; BORDER-BOTTOM: #eaeaea 1px solid } SPAN.page-header-spacer { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140%; VISIBILITY: hidden; = PADDING-BOTTOM: 4px; MARGIN: 15px 0px 0px } SPAN.booktitle { FONT-STYLE: italic } SPAN.journalname { FONT-STYLE: italic } SPAN.journalnumber { FONT-WEIGHT: bold } SPAN.tm { VERTICAL-ALIGN: super } LEGEND { COLOR: #000 } * HTML #breadcrumb DIV { MARGIN-TOP: 0px; PADDING-LEFT: 5px; PADDING-TOP: 1px } #breadcrumb DIV { CLEAR: left; MARGIN-TOP: 0px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 10px; PADDING-TOP: 1px } #breadcrumb DIV A:link { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:visited { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:hover { COLOR: #000; TEXT-DECORATION: underline } #breadcrumb SPAN.divider { FONT-SIZE: 70%; COLOR: #000 } #breadcrumb SPAN.thisitem { FONT-SIZE: 70%; COLOR: #000 } #login-inpage { MARGIN: 0px; COLOR: #000; BACKGROUND-COLOR: #eaeaea } #login-inpage A { FONT-SIZE: 70% } #login-inpage DIV.userpassbox { FLOAT: left; WIDTH: 8em } #login-inpage .passdetails { CLEAR: left } #login-inpage INPUT.text { FONT-SIZE: 80%; MARGIN: 0px; WIDTH: 9em; COLOR: #000 } #login-inpage LABEL { FONT-SIZE: 70% } #login-inpage INPUT.button { MARGIN-TOP: 5px } #login-inpage #savepass-inpage { MARGIN-BOTTOM: -2px } #login-inpage DIV.error { PADDING-LEFT: 20px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/login_error.gif) no-repeat 0px 4px; MARGIN-BOTTOM: = 5px; COLOR: #c30 } #login-inpage DIV.error SPAN { FONT-WEIGHT: bold } #head-er HR { DISPLAY: none } #head-er .header-nonad-wrapper { PADDING-BOTTOM: 15px; BORDER-BOTTOM: #fff 1px solid } #head-er .accessibility-login-wrap { FLOAT: left; WIDTH: 100%; BORDER-BOTTOM: #000 1px solid; = BACKGROUND-COLOR: #eaeaea } #head-er .accessibility-login { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 4px; TEXT-ALIGN: right } #head-er .accessibility-login A.nature-link { FLOAT: left; FONT: bold 160%/80% Garamond, serif; WIDTH: 4.9em; COLOR: = #b1062e; MARGIN-RIGHT: 20px; TEXT-ALIGN: left; TEXT-DECORATION: none } * HTML #head-er .accessibility-login A.nature-link:hover { BACKGROUND: none transparent scroll repeat 0% 0% } #head-er .accessibility-login A.nature-link:hover { BACKGROUND: = url(/common/includes/header/images/nature.com.underline.gif) no-repeat = left bottom } #head-er .accessibility-login IMG.nature-logo { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 1px 20px 0px 0px; WIDTH: 82px! = important; HEIGHT: 11px; BORDER-RIGHT-WIDTH: 0px } #head-er .accessibility-login .jumplinks { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 45%; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } #head-er .accessibility-login .jumplinks LI { DISPLAY: inline; PADDING-LEFT: 15px } #head-er .accessibility-login .jumplinks LI.first { PADDING-LEFT: 0px } #head-er .accessibility-login .jumplinks A { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/b1062e/arrow_down.gif) no-repeat left center; = COLOR: #000; TEXT-DECORATION: none } #head-er .accessibility-login .jumplinks A:hover { TEXT-DECORATION: underline } #head-er DIV.logon { =09 } #head-er .logon .onlyformacie { FONT-SIZE: 3px } #head-er .logon .onlyformacie { DISPLAY: none } #head-er .logon A.login { PADDING-RIGHT: 15px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logon.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon A.login:hover { BACKGROUND: url(/common/includes/header/images/logon_over.gif) = no-repeat right center; TEXT-DECORATION: underline } #head-er .logon A.login:active { BACKGROUND: url(/common/includes/header/images/logon.gif) no-repeat = right center } #head-er .logon A.logoff { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logoff.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon P { MARGIN: 0px } #head-er .logon .user { FONT-WEIGHT: bold } #head-er .logon .inst { FONT-WEIGHT: bold } #head-er .image-user-services-wrap { FLOAT: left; WIDTH: 100%; BACKGROUND-COLOR: #d6335c } #head-er .image-user-services { BORDER-BOTTOM: transparent 1px solid } * HTML #head-er .image-user-services { BORDER-BOTTOM-WIDTH: 0px } #head-er .image-user-services IMG.journal-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; WIDTH: 344px; HEIGHT: 74px; = BORDER-RIGHT-WIDTH: 0px } #head-er .user-services { FLOAT: right } #head-er .div1.user-services { WIDTH: 12.35em! important } #head-er .div2.user-services { WIDTH: 8.7em! important } #head-er .user-services UL { BORDER-RIGHT: #fff 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: #fff 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 22px 0px 21px; = BORDER-LEFT: #fff 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 0px = solid; LIST-STYLE-TYPE: none; TEXT-ALIGN: right } #head-er .user-services UL.list1 { BORDER-RIGHT: #fff 1px solid } #head-er .user-services LI { BORDER-BOTTOM: #fff 1px solid } #head-er .user-services A { PADDING-RIGHT: 13px; DISPLAY: block; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) #767474 no-repeat right = center; PADDING-BOTTOM: 1px; TEXT-TRANSFORM: uppercase; COLOR: #fff; = PADDING-TOP: 1px; TEXT-DECORATION: none } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .publications-search-wrap { BACKGROUND: #000 } * HTML #head-er .publications-search { PADDING-BOTTOM: 3px; PADDING-TOP: 3px } #head-er .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 4px; = PADDING-TOP: 4px } * HTML #head-er .publications { MARGIN: 6px 0px 0px } #head-er .publications { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4px 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #head-er .publications LI { DISPLAY: inline; MARGIN-LEFT: 10px } #head-er .publications LI.first { MARGIN-LEFT: 0px } #head-er .publications A { PADDING-RIGHT: 15px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .publications A:hover { TEXT-DECORATION: underline } #head-er .search { TEXT-ALIGN: right } #head-er .search FORM { DISPLAY: inline; MARGIN: 0px } #head-er .search FORM A { PADDING-RIGHT: 14px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .search FORM A:hover { TEXT-DECORATION: underline } #head-er #searchtext { WIDTH: 10em } #head-er .publications-search LABEL { TEXT-TRANSFORM: uppercase; COLOR: #fff } #head-er INPUT { FONT-SIZE: 100% } #head-er SELECT { FONT-SIZE: 100% } #head-er .publications-search INPUT.button { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px } #head-er .accessibility-login { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .image-user-services { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .publications-search { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } .header-leaderboard-wrap { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: = url(/common/includes/header/images/bg_leaderboard.gif) no-repeat 50% = 0px; OVERFLOW: hidden } .header-leaderboard { MAX-HEIGHT: 105px; TEXT-ALIGN: center } * HTML .header-leaderboard IMG { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard ilayer { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard IFRAME { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard EMBED { BORDER-BOTTOM-WIDTH: 1px } .header-leaderboard IMG { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard ilayer { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard IFRAME { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard EMBED { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard TABLE { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MAX-WIDTH: 728px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: auto; WIDTH: 100%; MARGIN-RIGHT: auto; PADDING-TOP: 0px; = BORDER-BOTTOM: #fff 1px solid; BORDER-RIGHT-WIDTH: 0px } * HTML .header-leaderboard TABLE IMG { HEIGHT: auto } #constrain { MARGIN-TOP: 14px } #global-subject-areas { BORDER-RIGHT: #ebebeb 1px solid; BORDER-TOP: #ebebeb 1px solid; = BACKGROUND: #ebebeb; MARGIN: 0px 0px 20px; BORDER-LEFT: #ebebeb 1px = solid; BORDER-BOTTOM: #ebebeb 1px solid } #global-subject-areas ABBR { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px; TEXT-DECORATION: none } #global-subject-areas A:link { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:visited { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:hover { TEXT-DECORATION: underline } #global-subject-areas H2 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #global-subject-areas UL UL { FONT-SIZE: 100% } #global-subject-areas UL LI { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = LINE-HEIGHT: 150%; PADDING-TOP: 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL LI LI { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #global-subject-areas UL LI H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H5 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H6 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav { DISPLAY: block; MARGIN-BOTTOM: 20px } MAP.journal-nav UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } MAP.journal-nav UL LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } MAP.journal-nav UL LI.grouped { BORDER-BOTTOM: #eaeaea 1px solid } * HTML MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } * HTML MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:hover { COLOR: #fff; BACKGROUND-COLOR: #c00; TEXT-DECORATION: none } MAP.journal-nav UL LI A.on { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.on:visited { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.submission { PADDING-LEFT: 20px! important; BACKGROUND: = url(/common/images/online_submissions.gif) no-repeat left center } MAP.journal-nav UL LI UL.subnav { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } MAP.journal-nav UL LI UL.subnav LI { BACKGROUND: url(/common/images/nav_dots2.gif) #fafafa no-repeat 11px = 5px; BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px } MAP.journal-nav UL LI UL.subnav LI.on { BACKGROUND: url(/common/images/nav_dots1.gif) #c00 no-repeat 11px 5px; = BORDER-BOTTOM: #fafafa 1px solid } * HTML MAP.journal-nav UL LI UL.subnav A { PADDING-RIGHT: 10px! important; PADDING-LEFT: 20px! important; = PADDING-BOTTOM: 2px! important; PADDING-TOP: 2px! important } MAP.journal-nav UL LI UL.subnav A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:hover { BACKGROUND: url(/common/images/nav_dots1.gif) #fab934 no-repeat 11px = 5px; COLOR: #fff; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A.on { COLOR: #fff } MAP.journal-nav UL LI UL.subnav A.on:visited { COLOR: #fff } #journalnav MAP.supplementary UL A { FONT-WEIGHT: normal; FONT-SIZE: 70% } #journalnav MAP.supplementary UL A:visited { FONT-WEIGHT: normal; FONT-SIZE: 70% } H2.society-resources { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #fab934 } UL.society-resources { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.society-resources LI { MARGIN: 0px; BACKGROUND-COLOR: #eaeaea } UL.society-resources A { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.society-resources A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.society-resources A:hover { COLOR: #fff; BACKGROUND-COLOR: #fab934; TEXT-DECORATION: none } DIV.society-logo { MARGIN-BOTTOM: 20px; TEXT-ALIGN: center } DIV.society-logo IMG { WIDTH: 100% } H2.npg-resources { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #b1062e } UL.npg-resources { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.npg-resources LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } UL.npg-resources A { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-resources A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-resources A:hover { COLOR: #fff; BACKGROUND-COLOR: #b1062e; TEXT-DECORATION: none } H2.npg-subjects { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #c03 } UL.npg-subjects { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.npg-subjects LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } UL.npg-subjects A { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-subjects A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-subjects A:hover { COLOR: #fff; BACKGROUND-COLOR: #c03; TEXT-DECORATION: none } UL.npg-subjects A.npgsubject-browseall:link { COLOR: #c03 } UL.npg-subjects A.npgsubject-browseall:visited { COLOR: #c03 } UL.npg-subjects A.npgsubject-browseall:hover { COLOR: #fff } A.backtotop:link { MARGIN-TOP: 5px; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_white_up.gif) no-repeat 0px 0.6em; FLOAT: = right; MARGIN-LEFT: 7px; COLOR: #fff; MARGIN-RIGHT: 10px } A.backtotop:visited { MARGIN-TOP: 5px; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_white_up.gif) no-repeat 0px 0.6em; FLOAT: = right; MARGIN-LEFT: 7px; COLOR: #fff; MARGIN-RIGHT: 10px } A.backtotop:hover { COLOR: #fff } H1.page { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #fab934; PADDING-BOTTOM: 3px; MARGIN: 0px 0px 10px; = COLOR: #fff; PADDING-TOP: 3px } IMG.arrow { MARGIN-RIGHT: 5px } A.arrow-blue { PADDING-LEFT: 10px; BACKGROUND: url(/common/images/arrow_blue.gif) = no-repeat 0px 0.5em } A.arrow-grey { PADDING-LEFT: 10px; BACKGROUND: url(/common/images/arrow_grey.gif) = no-repeat 0px 0.5em } A.arrow-red { PADDING-LEFT: 10px; BACKGROUND: url(/common/images/arrow_red.gif) = no-repeat 0px 0.5em } DIV.research-reviews { BORDER-RIGHT: #eaeaea 1px solid; BORDER-TOP: #eaeaea 1px solid; = MARGIN-BOTTOM: 2em; BORDER-LEFT: #eaeaea 1px solid; BORDER-BOTTOM: = #eaeaea 1px solid } DIV.research-reviews H1 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 90%; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #900; PADDING-TOP: 3px } DIV.research-reviews P { FONT-SIZE: 70%; MARGIN: 1em 10px; COLOR: #900 } DIV.research-reviews UL { PADDING-RIGHT: 0px; BORDER-TOP: #eaeaea 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px 10px 1em; PADDING-TOP: 1em; = LIST-STYLE-TYPE: none } DIV.research-reviews LI { MARGIN: 0px 0px 0.5em } DIV.research-reviews LI A { FONT-WEIGHT: bold; FONT-SIZE: 90% } DIV.research-reviews LI SPAN { FONT-SIZE: 70% } DIV.ad-horiz { CLEAR: both; BORDER-TOP: #eaeaea 1px solid; FONT-SIZE: 70%; = MARGIN-BOTTOM: 20px; COLOR: #ccc; PADDING-TOP: 10px; TEXT-ALIGN: center } DIV.ad-horiz IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 468px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 60px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-horiz EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 468px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 60px; BORDER-RIGHT-WIDTH: 0px } * HTML DIV.ad-horiz { MAX-WIDTH: 468px! important; MARGIN-LEFT: auto; OVERFLOW: hidden; = WIDTH: 100%; MARGIN-RIGHT: auto } #extranav A.topten:link { PADDING-RIGHT: 0px; BORDER-TOP: #eaeaea 1px solid; MARGIN-TOP: 0.6em; = DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat 0px 1.2em; PADDING-BOTTOM: = 0px; PADDING-TOP: 0.8em } #extranav A.topten:visited { PADDING-RIGHT: 0px; BORDER-TOP: #eaeaea 1px solid; MARGIN-TOP: 0.6em; = DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat 0px 1.2em; PADDING-BOTTOM: = 0px; PADDING-TOP: 0.8em } #extranav A.topten:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat 0px 1.2em; = TEXT-DECORATION: underline } DIV.ad-vert { FONT-SIZE: 70%; MARGIN-BOTTOM: 20px; COLOR: #ccc; TEXT-ALIGN: center } DIV.ad-vert IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 120px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 600px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-vert EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 120px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 600px; BORDER-RIGHT-WIDTH: 0px } * HTML DIV.ad-vert { MAX-WIDTH: 160px! important; MARGIN-LEFT: auto; OVERFLOW: hidden; = WIDTH: 100%; MARGIN-RIGHT: auto } .ad120x90 { CLEAR: both; FONT-SIZE: 80%; BACKGROUND: #fff; COLOR: #ccc; TEXT-ALIGN: = center } .ad120x90 IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; = BORDER-BOTTOM-WIDTH: 0px; MAX-WIDTH: 120px! important; MARGIN: 7px 0px; = WIDTH: 100%; HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .ad120x90 EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; = BORDER-BOTTOM-WIDTH: 0px; MAX-WIDTH: 120px! important; MARGIN: 7px 0px; = WIDTH: 100%; HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .box#natjob { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 6px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 6px; BACKGROUND: #fff; PADDING-BOTTOM: = 6px; MARGIN: 10px 0px; OVERFLOW: hidden; BORDER-LEFT: #e7e7e7 1px solid; = COLOR: #000; PADDING-TOP: 6px; BORDER-BOTTOM: #e7e7e7 1px solid } H2.natjob { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; FONT-SIZE: 120%; BACKGROUND: = #d8d8d8; PADDING-BOTTOM: 5px; MARGIN: 0px 0px 0.75em; TEXT-TRANSFORM: = lowercase; PADDING-TOP: 5px; LETTER-SPACING: -0.04em } H2.natjob A { TEXT-DECORATION: none } H2.natjob SPAN.first { COLOR: #f00 } H2.natjob SPAN.second { COLOR: #000 } UL.natjob { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none } UL.natjob H3 { FONT-WEIGHT: bold; FONT-SIZE: 110%; MARGIN: 10px 0px 0px } UL.natjob H3.first { MARGIN: 0px } UL.natjob H3 A:link { COLOR: #000; TEXT-DECORATION: underline! important } UL.natjob H3 A:visited { COLOR: #000; TEXT-DECORATION: underline! important } UL.natjob LI H3 A:hover { COLOR: #c03 } UL.natjob LI H3 A:focus { COLOR: #c03 } * HTML UL.natjob UL { LINE-HEIGHT: 120% } DIV.natjobmore { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-SIZE: 110%; PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: 5px } DIV.natjobmore A:link { DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/next.gif) no-repeat 0px 0.3em; MARGIN: 0px; = COLOR: #c03; TEXT-DECORATION: none } DIV.natjobmore A:visited { DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/next.gif) no-repeat 0px 0.3em; MARGIN: 0px; = COLOR: #c03; TEXT-DECORATION: none } .box#natjob DIV.natjobmore A:hover { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); = TEXT-DECORATION: underline } .box#natjob DIV.natjobmore A:focus { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); = TEXT-DECORATION: underline } UL.natjob UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } P.natjobmore { PADDING-BOTTOM: 5px; MARGIN: 0px } P.nateventmore { PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: 5px } .box#natprod { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 6px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 6px; BACKGROUND: #fff; PADDING-BOTTOM: = 6px; MARGIN: 10px 0px; BORDER-LEFT: #e7e7e7 1px solid; COLOR: #000; = PADDING-TOP: 6px; BORDER-BOTTOM: #e7e7e7 1px solid } H2.natprod { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; FONT-SIZE: 120%; BACKGROUND: = #d8d8d8; PADDING-BOTTOM: 5px; MARGIN: 0px 0px 0.75em; TEXT-TRANSFORM: = lowercase; PADDING-TOP: 5px; LETTER-SPACING: -0.04em } H2.natprod A { TEXT-DECORATION: none } H2.natprod SPAN.first { COLOR: #f00 } H2.natprod SPAN.second { COLOR: #000 } .box#natprod FORM { MARGIN: 0px } DIV.natprod { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 4px; PADDING-LEFT: 4px; = BACKGROUND: #f3f2f2; PADDING-BOTTOM: 4px; BORDER-LEFT: black 1px solid; = PADDING-TOP: 4px; BORDER-BOTTOM: black 1px solid } DIV.natprodmore { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0.75em; = PADDING-TOP: 0px } DIV.natprodmore A:link { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: none } DIV.natprodmore A:visited { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: none } DIV.natprodmore A:focus { TEXT-DECORATION: underline } DIV.natprodmore A:hover { TEXT-DECORATION: underline } DIV.natprod SPAN { DISPLAY: block; FONT-SIZE: 70%; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 110% } #natprod FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.natprodmore FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.natprodmore INPUT { MARGIN-TOP: 5px; FONT-SIZE: 110%; WIDTH: 98%! important } * HTML DIV.natprodmore INPUT { WIDTH: 96%! important } DIV.natprodmore INPUT { WIDTH: 80% } DIV.natprodmore INPUT { WIDTH: 100% } DIV.natprodmore INPUT.button { FONT-WEIGHT: bold; COLOR: #fff; BACKGROUND-COLOR: #000 } #article-related #journal-header { DISPLAY: none } #article-related H2.atl { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article-related H2.figure-title { CLEAR: both; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related P.from { FONT-WEIGHT: bold; FONT-SIZE: 70%; MARGIN: 0px; COLOR: #c03 } #article-related P.aug { FONT-SIZE: 70%; MARGIN: 0px } #article-related A.back-to-article:link { CLEAR: both; PADDING-RIGHT: 1em; PADDING-LEFT: 1em; FONT-WEIGHT: bold; = FONT-SIZE: 70%; BACKGROUND: #000; FLOAT: right; PADDING-BOTTOM: 3px; = MARGIN: 10px 0px; COLOR: #fff; PADDING-TOP: 3px; TEXT-DECORATION: none } #article-related A.back-to-article:visited { CLEAR: both; PADDING-RIGHT: 1em; PADDING-LEFT: 1em; FONT-WEIGHT: bold; = FONT-SIZE: 70%; BACKGROUND: #000; FLOAT: right; PADDING-BOTTOM: 3px; = MARGIN: 10px 0px; COLOR: #fff; PADDING-TOP: 3px; TEXT-DECORATION: none } #article-related A.back-to-article:hover { BACKGROUND: #fab934; COLOR: #fff; TEXT-DECORATION: none } #article-related DIV.container-image { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: #eaeaea; PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; = PADDING-TOP: 10px; TEXT-ALIGN: center } #article-related DIV.container-image-text { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: #eaeaea; PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; = PADDING-TOP: 10px } #article-related DIV.container-image-text P { FONT-SIZE: 90% } #article-related FORM { MARGIN: 0px } #article-related DIV.container-image-text UL { FONT-SIZE: 90% } #article-related DIV.container-image-text OL { FONT-SIZE: 90% } #article-related DIV.prevnext { CLEAR: both; BORDER-RIGHT: black 1px solid; BORDER-TOP: black 1px = solid; BACKGROUND: #fff; BORDER-LEFT: black 1px solid; BORDER-BOTTOM: = black 1px solid; TEXT-ALIGN: center } #article-related DIV.prevnext .hide { DISPLAY: none } #article-related DIV.prevnext A { FONT: 70% verdana, arial, helvetica, sans-serif; TEXT-DECORATION: none } #article-related A.previous:link { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: url(/common/images/arrow_blue_left.gif) no-repeat left = center; FLOAT: left; PADDING-BOTTOM: 2px; MARGIN-LEFT: 10px; = PADDING-TOP: 2px } #article-related A.previous:visited { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: url(/common/images/arrow_blue_left.gif) no-repeat left = center; FLOAT: left; PADDING-BOTTOM: 2px; MARGIN-LEFT: 10px; = PADDING-TOP: 2px } #article-related A.previous:hover { BACKGROUND: url(/common/images/arrow_red_left.gif) no-repeat left = center } #article-related A.index:link { PADDING-RIGHT: 5px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue_up.gif) no-repeat left center; = PADDING-BOTTOM: 2px; VERTICAL-ALIGN: middle; PADDING-TOP: 2px } #article-related A.index:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue_up.gif) no-repeat left center; = PADDING-BOTTOM: 2px; VERTICAL-ALIGN: middle; PADDING-TOP: 2px } #article-related A.index:hover { BACKGROUND: url(/common/images/arrow_red_up.gif) no-repeat left center } #article-related A.next:link { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat right center; FLOAT: right; = PADDING-BOTTOM: 2px; BORDER-LEFT: black 1px solid; MARGIN-RIGHT: 10px; = PADDING-TOP: 2px } #article-related A.next:visited { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat right center; FLOAT: right; = PADDING-BOTTOM: 2px; BORDER-LEFT: black 1px solid; MARGIN-RIGHT: 10px; = PADDING-TOP: 2px } #article-related A.next:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat right center } #article-related DIV.container-figtab { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 0px solid } #article-related DIV.last { BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-figtab DIV.container-image IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 150px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-figtab DIV.container-image { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; FLOAT: left; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; WIDTH: = 150px; PADDING-TOP: 0px; TEXT-ALIGN: right; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-figtab DIV.container-image-text { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN-LEFT: 160px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-figtab DIV.container-image-text H3 { FONT-SIZE: 90%; MARGIN: 0px } #article-related DIV.container-figtab DIV.container-image-text P { FONT-SIZE: 90%; MARGIN: 0px } #article-related DIV.container-figtab A.full { MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: 25px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/full_figure.gif) no-repeat 0px 0px } #article-related DIV.container-figtab A.pdb { MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: 25px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/icons/pdb_small.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 3px } #article-related DIV.container-figtab A.threed-view { MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: 25px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/icons/threed_small.gif) no-repeat 0px = 0px; PADDING-BOTTOM: 3px } #article-related DIV.container-figtab A.pp { PADDING-RIGHT: 0px; MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: = 25px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/icons/fff/powerpoint.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 4px; PADDING-TOP: 0px } #article-related DIV.container-supplementary { CLEAR: both; BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 0px; = PADDING-LEFT: 0px; BACKGROUND: #eaeaea; PADDING-BOTTOM: 0px; = BORDER-LEFT: black 1px solid; PADDING-TOP: 0px } #article-related A.download-plugins:link { CLEAR: both; BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 0px; = BORDER-TOP: black 1px solid; DISPLAY: block; PADDING-LEFT: 17px; = FONT-SIZE: 70%; BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat = 10px 0.45em; PADDING-BOTTOM: 3px; BORDER-LEFT: black 1px solid; = PADDING-TOP: 0px; BORDER-BOTTOM: black 1px solid } #article-related A.download-plugins:visited { CLEAR: both; BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 0px; = BORDER-TOP: black 1px solid; DISPLAY: block; PADDING-LEFT: 17px; = FONT-SIZE: 70%; BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat = 10px 0.45em; PADDING-BOTTOM: 3px; BORDER-LEFT: black 1px solid; = PADDING-TOP: 0px; BORDER-BOTTOM: black 1px solid } #article-related A.download-plugins:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat 10px 0.45em } #article-related DIV.container-supplementary H2 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 10px } #article-related DIV.container-supplementary P { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 90%; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: = black 1px solid } #article-related DIV.container-supplementary P.last { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 0px } #article-related DIV.container-sendfriend { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-plugins { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { BORDER-BOTTOM-WIDTH: 0px } #article-related DIV.wrapper { MARGIN-BOTTOM: 10px } #article-related P.explain { FONT-SIZE: 70%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P.last { MARGIN: 0px } #article-related P.results { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related A.article { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article-related P.journal { FONT-SIZE: 70%; MARGIN: 0px } #article-related DIV.container-more2 P.journal { MARGIN-BOTTOM: 1em } #article-related H3.area { FONT-WEIGHT: normal; FONT-SIZE: 70%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase } #article-related A.allmatches:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related A.allmatches:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related A.allmatches:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat left center } #article-related DIV.text { FLOAT: left; WIDTH: 210px; TEXT-ALIGN: right } #article-related DIV.text LABEL { FONT-WEIGHT: bold; FONT-SIZE: 90% } #article-related DIV.text P { FONT-SIZE: 70%; MARGIN: 0px } #article-related DIV.form { MARGIN-LEFT: 220px } #article-related DIV.form INPUT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.form TEXTAREA { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.form INPUT { WIDTH: 100% } #article-related DIV.form TEXTAREA { WIDTH: 100% } #article-related INPUT.friend { CLEAR: both; FLOAT: right } * HTML #article-related TABLE.data { FONT-SIZE: 100% } #article-related TABLE.data { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: = #999 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #999 1px solid; = BORDER-COLLAPSE: collapse; TEXT-ALIGN: left } #article-related TABLE.data THEAD { FONT-WEIGHT: bold } #article-related TABLE.data THEAD TH { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0.5em; PADDING-LEFT: = 0.5em; FONT-SIZE: 90%; BACKGROUND: #f6f6f6; PADDING-BOTTOM: 0.5em; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 0px } #article-related TABLE.data THEAD TH.colspan { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 0px solid; BORDER-LEFT: = #999 1px solid; BORDER-BOTTOM: #999 1px solid; TEXT-ALIGN: center } #article-related TABLE.data THEAD TH.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.rowsep { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data THEAD TH.rowsep { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY { BORDER-TOP: #999 1px solid; BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TR { BACKGROUND-COLOR: #f6f6f6 } #article-related TABLE.data TBODY TR.odd { BACKGROUND-COLOR: #fff } #article-related TABLE.data TBODY TD { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0.5em; PADDING-LEFT: = 0.5em; FONT-SIZE: 90%; PADDING-BOTTOM: 0.15em; PADDING-TOP: 0.15em } #article-related TABLE.data TFOOT TD { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; FONT-SIZE: 90%; = PADDING-BOTTOM: 0.5em; PADDING-TOP: 0.5em; BACKGROUND-COLOR: #fff } #foot-er { BORDER-TOP-WIDTH: 0px; CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 20px 0px; PADDING-TOP: 0px } #foot-er #footer-journal { PADDING-RIGHT: 1%; BORDER-TOP: #000 1px solid; PADDING-LEFT: 1%; = BACKGROUND: #eee; PADDING-BOTTOM: 2px; PADDING-TOP: 2px } #foot-er #footer-journal:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #foot-er #footer-journal { HEIGHT: 1% } #foot-er #footer-journal P { PADDING-RIGHT: 1em; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 1em 0px 0px; PADDING-TOP: 0px } #foot-er #footer-journal P.journal-name { FONT-WEIGHT: bold; FONT-SIZE: 100%; FONT-STYLE: italic } #foot-er #footer-journal P.issn { FONT-SIZE: 100% } #foot-er #footer-journal P.eissn { FONT-SIZE: 100% } #foot-er #footer-journal P.extra { FONT-SIZE: 100% } #foot-er #footer-links { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: #000; PADDING-BOTTOM: = 5px; PADDING-TOP: 5px } #foot-er #footer-links UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #foot-er #footer-links UL LI { DISPLAY: inline } #foot-er #footer-links UL LI A:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #foot-er #footer-links UL LI A:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } * HTML #foot-er #footer-links UL LI A:link { DISPLAY: inline } * HTML #foot-er #footer-links UL LI A:visited { DISPLAY: inline } #foot-er #footer-links UL LI A:hover { TEXT-DECORATION: underline } #foot-er #footer-links UL LI A.about-npg:link { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-links UL LI A.about-npg:visited { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-copyright { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left! important } * HTML #foot-er #footer-copyright .footer-constrain { TEXT-ALIGN: left } #foot-er #footer-copyright A { COLOR: #b1062e } #foot-er #footer-copyright P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 5px } #foot-er #footer-copyright P.logo { PADDING-RIGHT: 36px; PADDING-LEFT: 36px; BACKGROUND: = url(/common/images/npg_logo.gif) no-repeat 0px 50%; PADDING-BOTTOM: 7px; = MARGIN: 5px 0px 0px; PADDING-TOP: 7px } #foot-er #footer-copyright P A:link { FONT-WEIGHT: bold; TEXT-DECORATION: none } #foot-er #footer-copyright P A:visited { FONT-WEIGHT: bold; TEXT-DECORATION: none } #foot-er #footer-copyright P A.footer-copyright:link { FONT-WEIGHT: normal; COLOR: #000 } #foot-er #footer-copyright P A.footer-copyright:visited { FONT-WEIGHT: normal; COLOR: #000 } #foot-er #footer-copyright P A:hover { TEXT-DECORATION: underline } #content .scp { FONT-VARIANT: small-caps } DIV.ab-ad { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; BACKGROUND: #eaeaea; = MARGIN-BOTTOM: 15px; PADDING-BOTTOM: 3px; PADDING-TOP: 0px; TEXT-ALIGN: = center } DIV.ab-ad H2.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H4.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H5.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H6.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad H6.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad DIV.container { BORDER-RIGHT: #e0ebf9 1px solid; BORDER-TOP: #e0ebf9 1px solid; = MARGIN-TOP: 3px; BORDER-LEFT: #e0ebf9 1px solid; BORDER-BOTTOM: #e0ebf9 = 1px solid; BACKGROUND-COLOR: #fff } DIV.ab-ad UL { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 5px; MARGIN: 0px; TEXT-TRANSFORM: none; PADDING-TOP: = 5px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } DIV.ab-ad UL UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } DIV.ab-ad LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: = 0px; PADDING-TOP: 2px } DIV.ab-ad A { COLOR: #0068b3 } DIV.ab-ad A.sponsor IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 118px; WIDTH: 100%; BORDER-RIGHT-WIDTH: 0px } DIV.ab-ad P.blurb { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 5px 5px; PADDING-TOP: 0px; TEXT-ALIGN: left } .eotm-jotw { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: 0px = 0px 20px; OVERFLOW: hidden; BORDER-LEFT: #e7e7e7 1px solid; PADDING-TOP: = 0px; BORDER-BOTTOM: #e7e7e7 1px solid; LIST-STYLE-TYPE: none; = BACKGROUND-COLOR: #fff } .eotm-jotw .main-heading { PADDING-RIGHT: 10px; PADDING-LEFT: 48px; FONT-SIZE: 110%; BACKGROUND: = url(/common/images/eotm_jotw_bg.jpg) no-repeat 0px 0px; PADDING-BOTTOM: = 10px; MARGIN: 0px; PADDING-TOP: 10px } .eotm-jotw .main-heading .type { DISPLAY: block; COLOR: #f00 } .eotm-jotw .main-heading .timeframe { FONT-WEIGHT: normal; FONT-SIZE: 100% } .eotm-jotw .main-heading .job-or-event { TEXT-TRANSFORM: uppercase } .eotm-jotw .events-jobs { PADDING-RIGHT: 8px; PADDING-LEFT: 8px; PADDING-BOTTOM: 0px; MARGIN: = -70px 0px 0px; PADDING-TOP: 70px; LIST-STYLE-TYPE: none } .jotw .events-jobs { BACKGROUND: url(/common/images/jotw.gif) no-repeat 10px 30px } .eotm .events-jobs { BACKGROUND: url(/common/images/eotm.gif) no-repeat 10px 30px } .eotm-jotw .title { FONT-SIZE: 100%; MARGIN: 10px 0px 0px } .eotm-jotw .events-jobs P { FONT-SIZE: 100%; MARGIN: 0px 0px 10px } .eotm-jotw .events-jobs P SPAN { FONT-WEIGHT: bold } .eotm-jotw .more { CLEAR: both; PADDING-RIGHT: 8px; DISPLAY: block; PADDING-LEFT: 15px; = BACKGROUND: url(/common/images/icons/next.gif) no-repeat 0px 0.6ex; = MARGIN: 10px 0px 0px 8px; LINE-HEIGHT: 110%; TEXT-DECORATION: none } .eotm-jotw .more .link { FONT-SIZE: 100%; TEXT-DECORATION: underline } .eotm-jotw .site { MARGIN-TOP: 0.5ex; DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; = COLOR: #444; FONT-FAMILY: Georgia, serif; LETTER-SPACING: -0.04em } .eotm-jotw .site .nature { COLOR: #f33 } INPUT.sermo-submit { PADDING-RIGHT: 0px; BACKGROUND-POSITION: 6px center; DISPLAY: block; = PADDING-LEFT: 10%; FONT-SIZE: 100%; PADDING-BOTTOM: 5px; MARGIN: 0px; = WIDTH: 100%; CURSOR: pointer; COLOR: #000; BORDER-TOP-STYLE: none; = PADDING-TOP: 5px; BACKGROUND-REPEAT: no-repeat; FONT-FAMILY: = Verdana,arial,Helvetica,sans-serif; BORDER-RIGHT-STYLE: none; = BORDER-LEFT-STYLE: none; BACKGROUND-COLOR: #f3f3f3; TEXT-ALIGN: left; = BORDER-BOTTOM-STYLE: none } INPUT.sermo-submit:hover { BACKGROUND-COLOR: #eaeaea! important } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/reviews/style/group.css #hdr { FONT-SIZE: 140%; BORDER-LEFT-COLOR: #f5f5f5; BORDER-BOTTOM-COLOR: = #f5f5f5; BORDER-TOP-COLOR: #f5f5f5; BORDER-RIGHT-COLOR: #f5f5f5 } #ftr { FONT-SIZE: 100% } #hdr .search SELECT { FONT-SIZE: 100% } #hdr .search INPUT { FONT-SIZE: 100% } BODY { BACKGROUND-IMAGE: url(/reviews/images/bg_body.gif) } #constrain { BACKGROUND-IMAGE: url(/reviews/images/bg_constrain.gif) } * HTML BODY { FONT-SIZE: 62.5% } * HTML BODY { FONT-SIZE: 63% } BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 62.5%; BACKGROUND: = #f5f5f5; PADDING-BOTTOM: 20px; MARGIN: 0px; COLOR: #000; PADDING-TOP: = 0px; FONT-FAMILY: Verdana, arial, Helvetica, sans-serif } .global-message H1 { FONT-SIZE: 140% } .global-message .content P { FONT-SIZE: 110% } #content A.backtotop:link { PADDING-RIGHT: 13px; DISPLAY: block; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/backtotop.gif) no-repeat right center; FLOAT: = none; MARGIN: 0.5em 10px; TEXT-TRANSFORM: lowercase; COLOR: #000; = TEXT-ALIGN: right; TEXT-DECORATION: none } #content A.backtotop:visited { PADDING-RIGHT: 13px; DISPLAY: block; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/backtotop.gif) no-repeat right center; FLOAT: = none; MARGIN: 0.5em 10px; TEXT-TRANSFORM: lowercase; COLOR: #000; = TEXT-ALIGN: right; TEXT-DECORATION: none } #content .box A.backtotop:link { MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } #content .box A.backtotop:visited { MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } #content A.backtotop:hover { BACKGROUND: url(/common/images/icons/backtotop_hover.gif) no-repeat = right center; COLOR: #c03 } #content A.backtotop:focus { BACKGROUND: url(/common/images/icons/backtotop_hover.gif) no-repeat = right center; COLOR: #c03 } A IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } ABBR { BORDER-BOTTOM-WIDTH: 0px; TEXT-DECORATION: none } ACRONYM { BORDER-BOTTOM-WIDTH: 0px; TEXT-DECORATION: none } ABBR:hover { CURSOR: help } ACRONYM:hover { CURSOR: help } KBD { FONT-SIZE: 120% } .author { FONT-WEIGHT: bold } .char-img { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .icon { BACKGROUND-POSITION: left center; PADDING-LEFT: 19px; PADDING-BOTTOM: = 3px; BACKGROUND-REPEAT: no-repeat } .i-audio.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/audio.gif) } .i-audio-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/audio_grey.gif) } .i-bitmap.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/bitmap.gif) } .i-bitmap-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/bitmap_grey.gif) } .i-compressed.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/compressed.gif) } .i-compressed-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/compressed_grey.gif) } .i-markup.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/markup.gif) } .i-markup-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/markup_grey.gif) } .i-movie.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/movie.gif) } .i-movie-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/movie_grey.gif) } .i-pdf.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/pdf.gif) } .i-pdf-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/pdf_grey.gif) } .i-postscript.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/printer.gif) } .i-postscript-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/printer_grey.gif) } .i-powerpoint.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/ppt.gif) } .i-powerpoint-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/ppt_grey.gif) } .i-svg.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/svg.gif) } .i-sif.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/sif.gif) } .i-sif-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/sif_grey.gif) } .i-svg-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/svg_grey.gif) } .i-text.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/text.gif) } .i-text-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/text_grey.gif) } .i-word.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/word.gif) } .i-word-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/word_grey.gif) } .i-xls.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/xls.gif) } .i-xls-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/xls_grey.gif) } .i-microarray.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/microarray.gif) } .i-chemical-structures.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/chemical_structures.gif) } .plugin-audio.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/audio.gif) } .plugin-audio-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/audio_grey.gif) } .plugin-bitmap.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/bitmap.gif) } .plugin-bitmap-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/bitmap_grey.gif) } .plugin-compressed.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/compressed.gif) } .plugin-compressed-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/compressed_grey.gif) } .plugin-markup.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/markup.gif) } .plugin-markup-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/markup_grey.gif) } .plugin-movie.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/movie.gif) } .plugin-movie-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/movie_grey.gif) } .plugin-pdf.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/pdf.gif) } .plugin-pdf-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/pdf_grey.gif) } .plugin-postscript.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/printer.gif) } .plugin-postscript-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/printer_grey.gif) } .plugin-powerpoint.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/ppt.gif) } .plugin-powerpoint-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/ppt_grey.gif) } .plugin-sif.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/sif.gif) } .plugin-svg.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/svg.gif) } .plugin-svg-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/svg_grey.gif) } .plugin-word.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/word.gif) } .plugin-word-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/word_grey.gif) } .plugin-xls.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/xls.gif) } .plugin-xls-grey.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/xls_grey.gif) } .plugin-microarray.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/microarray.gif) } .plugin-chemical-structures.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/chemical_structures.gif) } .plugin-text.icon { BACKGROUND-IMAGE: url(/reviews/images/icons/text.gif) } .important { FONT-WEIGHT: bold } .journal-name { FONT-STYLE: italic } .journalname { FONT-STYLE: italic } .jtl { FONT-STYLE: italic } .journal-volume { FONT-WEIGHT: bold } .noborder { BORDER-TOP-WIDTH: 0px! important; BORDER-LEFT-WIDTH: 0px! important; = BORDER-BOTTOM-WIDTH: 0px! important; BORDER-RIGHT-WIDTH: 0px! important } .term { TEXT-TRANSFORM: uppercase } .valign-bottom { VERTICAL-ALIGN: bottom } .valign-middle { VERTICAL-ALIGN: middle } .valign-top { VERTICAL-ALIGN: top } .vid { FONT-WEIGHT: bold } #content-journalnav { BORDER-TOP-COLOR: #f5f5f5 } #extranav { BORDER-TOP: #f5f5f5 1px solid } * HTML #article-related #breadcrumb { MARGIN-LEFT: 1%; MARGIN-RIGHT: 1% } #head-er .header-nonad-wrapper { BORDER-BOTTOM-COLOR: #f5f5f5 } .header-leaderboard IMG { BORDER-BOTTOM-COLOR: #f5f5f5 } .header-leaderboard ilayer { BORDER-BOTTOM-COLOR: #f5f5f5 } .header-leaderboard IFRAME { BORDER-BOTTOM-COLOR: #f5f5f5 } .header-leaderboard EMBED { BORDER-BOTTOM-COLOR: #f5f5f5 } .header-leaderboard-wrap { BACKGROUND-IMAGE: url(/reviews/images/bg_leaderboard.gif) } #breadcrumb { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 10px; PADDING-TOP: 0px } DIV#breadcrumb DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px } #breadcrumb DIV A:link { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px } #breadcrumb DIV A:visited { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px } #breadcrumb DIV SPAN.thisitem { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px } DIV#breadcrumb DIV { =09 } #article-related DIV#breadcrumb DIV { MARGIN-LEFT: 0px } #breadcrumb DIV A:link { TEXT-DECORATION: underline } #breadcrumb DIV A:visited { TEXT-DECORATION: underline } #content { BACKGROUND: #fff; COLOR: #000 } MAP.journal-nav { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } MAP.journal-nav UL { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 6px; MARGIN: 0px = 0px 10px; PADDING-TOP: 6px } MAP.journal-nav UL LI { MARGIN: 0px } MAP.journal-nav UL LI.menu-heading H2 { FONT-SIZE: 110%; MARGIN: 0px 0px 10px } MAP#main-journal-nav UL LI.menu-heading H2 { TEXT-TRANSFORM: uppercase } * HTML MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } * HTML MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } MAP.journal-nav UL LI A:link { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: normal; FONT-SIZE: = 110%; PADDING-BOTTOM: 4px; PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: normal; FONT-SIZE: = 110%; PADDING-BOTTOM: 4px; PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.supplementary.journal-nav UL LI A:link { FONT-WEIGHT: normal } MAP.supplementary.journal-nav UL LI A:visited { FONT-WEIGHT: normal } MAP.journal-nav UL LI A:hover { TEXT-DECORATION: none } MAP.journal-nav UL LI A:focus { TEXT-DECORATION: none } MAP.journal-nav UL LI.selected A:link { TEXT-DECORATION: none } MAP.journal-nav UL LI.selected A:visited { TEXT-DECORATION: none } #journalnav MAP.supplementary UL A:link { FONT-WEIGHT: normal; FONT-SIZE: 110% } #journalnav MAP.supplementary UL A:visited { FONT-WEIGHT: normal; FONT-SIZE: 110% } MAP.supplementary.journal-nav UL LI A.onsub:link { PADDING-LEFT: 23px } MAP.supplementary.journal-nav UL LI A.onsub:visited { PADDING-LEFT: 23px } MAP.journal-nav UL LI UL.subnav { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } * HTML MAP.journal-nav UL LI UL.subnav A { PADDING-RIGHT: 10px! important; PADDING-LEFT: 20px! important; = PADDING-BOTTOM: 2px! important; PADDING-TOP: 2px! important } MAP.journal-nav UL LI UL.subnav A:link { FONT-SIZE: 110% } MAP.journal-nav UL LI UL.subnav A:visited { FONT-SIZE: 110% } DIV#npg-resources { BORDER-RIGHT: #fff 1px solid; BORDER-TOP: #fff 1px solid; = MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 0px; BORDER-LEFT: #fff 1px solid; = BORDER-BOTTOM: #fff 0px solid } H2.npg-resources { FONT-SIZE: 120%; BACKGROUND-COLOR: #b1062e } * HTML DIV#npg-resources H2 { BORDER-RIGHT: #fff 1px solid; BORDER-TOP: #fff 1px solid; BORDER-LEFT: = #fff 1px solid; BORDER-BOTTOM: #fff 0px solid } DIV#npg-resources UL.npg-resources { MARGIN-BOTTOM: 0px; BACKGROUND-COLOR: red } * HTML DIV#npg-resources UL.npg-resources LI { BORDER-RIGHT: #fff 1px solid; BORDER-LEFT: #fff 1px solid } UL.npg-resources A:link { FONT-SIZE: 110%; BACKGROUND-COLOR: #ebebeb } UL.npg-resources A:visited { FONT-SIZE: 110%; BACKGROUND-COLOR: #ebebeb } UL.npg-resources A:hover { BACKGROUND-COLOR: #b1062e } DIV#npg-services H2 { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 120%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #b1062e } DIV#npg-services UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } DIV#npg-services UL LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } DIV#npg-services UL A:link { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; PADDING-BOTTOM: 3px! important; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 3px! important; TEXT-DECORATION: none } DIV#npg-services UL A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; PADDING-BOTTOM: 3px! important; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 3px! important; TEXT-DECORATION: none } DIV#npg-services UL A:hover { COLOR: #fff; BACKGROUND-COLOR: #b1062e; TEXT-DECORATION: none } DIV#npg-services { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 5px; BACKGROUND: #fff; MARGIN-BOTTOM: = 10px; PADDING-BOTTOM: 5px; BORDER-LEFT: #e7e7e7 1px solid; PADDING-TOP: = 5px; BORDER-BOTTOM: #e7e7e7 1px solid } DIV#npg-services H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 10px; COLOR: = #000; PADDING-TOP: 0px } DIV#npg-services UL { MARGIN-BOTTOM: 0px } DIV#npg-services UL LI A:link { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-SIZE: 110%; PADDING-BOTTOM: = 4px; PADDING-TOP: 4px; BACKGROUND-COLOR: #f4dddd } DIV#npg-services UL LI A:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-SIZE: 110%; PADDING-BOTTOM: = 4px; PADDING-TOP: 4px; BACKGROUND-COLOR: #f4dddd } DIV#npg-services UL LI A:hover { COLOR: #000; BACKGROUND-COLOR: #efc9c9 } DIV#global-subject-areas { BORDER-LEFT-COLOR: #fff; BORDER-BOTTOM-COLOR: #fff; BORDER-TOP-COLOR: = #fff; BORDER-RIGHT-COLOR: #fff } DIV.marketing.ad-rh { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: 0px = 0px 10px; PADDING-TOP: 5px; TEXT-ALIGN: left } * HTML DIV.marketing { BACKGROUND: #fff; MARGIN-BOTTOM: 10px } DIV.marketing.ad-rh DIV { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } DIV.marketing.ad-rh H2 { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } DIV.marketing.ad-rh P { FONT-WEIGHT: bold; MARGIN: 0px; COLOR: #000; TEXT-ALIGN: center } * HTML DIV.marketing.ad-rh P { FONT-WEIGHT: bold; MARGIN: 0px; COLOR: #000; TEXT-ALIGN: center } DIV.marketing.ad-rh FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 1em = 0px 0px; PADDING-TOP: 0px; TEXT-ALIGN: center } DIV.marketing.ad-rh FORM INPUT { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 3px; FONT: = bold 100% Verdana, Arial, Helvetica, sans-serif; PADDING-TOP: 3px } * HTML DIV.marketing.ad-rh FORM INPUT { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } DIV.reg-rec { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 6px; MARGIN: 0px = 0px 10px; PADDING-TOP: 6px } DIV.reg-rec UL { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; PADDING-BOTTOM: 2px; MARGIN: = 0px; PADDING-TOP: 2px; LIST-STYLE-TYPE: none } DIV.reg-rec UL LI { MARGIN: 8px 0px } DIV.reg-rec UL LI A:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 22px; FONT-SIZE: = 110%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-DECORATION: none } DIV.reg-rec UL LI A:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 22px; FONT-SIZE: = 110%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-DECORATION: none } DIV.links.reg-rec UL LI A:link { PADDING-LEFT: 5px } DIV.links.reg-rec UL LI A:visited { PADDING-LEFT: 5px } DIV.reg-rec UL LI A:hover { TEXT-DECORATION: underline } DIV.reg-rec UL LI A:focus { TEXT-DECORATION: underline } DIV.reg-rec UL A.e-alerts { BACKGROUND: url(/reviews/images/icons/signup.gif) no-repeat 0px 3px } DIV.reg-rec UL A.recommend { BACKGROUND: url(/reviews/images/icons/tick.gif) no-repeat 0px 1px } DIV.reg-rec UL A.newsfeeds { BACKGROUND: url(/reviews/images/icons/newsfeeds.gif) no-repeat 0px 0px } DIV.reg-rec UL A.rtopten { BACKGROUND: url(/reviews/images/icons/topten.gif) no-repeat 0px 0px; = HEIGHT: 18px } DIV.reg-rec UL A.purchase { BACKGROUND: url(/reviews/images/icons/purchase.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 2px; PADDING-TOP: 2px } DIV.reg-rec UL A.bookmark { BACKGROUND: url(/reviews/images/icons/bookmark.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } * HTML DIV.reg-rec UL A.japanese { BACKGROUND: url(/reviews/images/icons/japanese.gif) no-repeat 0px 3px } DIV.reg-rec UL A.japanese { BACKGROUND: url(/reviews/images/icons/japanese.gif) no-repeat 0px 1px; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } .box#natjob { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 6px; MARGIN: 0px = 0px 10px; COLOR: #000; PADDING-TOP: 6px } .box#natjob H2.natjob { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 7px; PADDING-LEFT: 7px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 120%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px; FONT-FAMILY: = inherit; BORDER-RIGHT-WIDTH: 0px } .box#natjob H2.natjob SPAN.first { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natjob H2.natjob SPAN.second { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natjob H2.natjob SPAN.third { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natjob H2.natjob SPAN.first { COLOR: #f00 } .box#natjob H2.natjob SPAN.second { COLOR: #000 } .box#natjob UL.natjob { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 10px; MARGIN: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .box#natjob UL.natjob LI H3 { FONT-SIZE: 110% } .box#natjob UL.natjob LI UL { FONT-SIZE: 110% } .box#natjob UL.natjob LI H3 A:link { TEXT-DECORATION: none } .box#natjob UL.natjob LI H3 A:visited { TEXT-DECORATION: none } .box#natjob UL.natjob LI H3 A:hover { TEXT-DECORATION: underline } .box#natjob UL.natjob LI H3 A:focus { TEXT-DECORATION: underline } .box#natjob DIV.natjobmore { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 110%; BACKGROUND-IMAGE: none; = BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: = 5px; LIST-STYLE-TYPE: none; BACKGROUND-COLOR: transparent; = BORDER-RIGHT-WIDTH: 0px } .box#natjob DIV.natjobmore A:link { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: = 100%; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = TEXT-DECORATION: none } .box#natjob DIV.natjobmore A:visited { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: = 100%; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = TEXT-DECORATION: none } .box#natjob DIV.natjobmore A:hover { TEXT-DECORATION: underline } .box#natjob DIV.natjobmore A:focus { TEXT-DECORATION: underline } .box#natprod { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 6px; MARGIN: 0px = 0px 10px; COLOR: #000; PADDING-TOP: 6px } .box#natprod H2.natprod { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 7px; PADDING-LEFT: 7px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 120%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px; FONT-FAMILY: = inherit; BORDER-RIGHT-WIDTH: 0px } .box#natprod H2.natprod SPAN.first { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natprod H2.natprod SPAN.second { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natprod H2.natprod SPAN.third { TEXT-TRANSFORM: lowercase; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif } .box#natprod H2.natprod SPAN.first { COLOR: #f00 } .box#natprod H2.natprod SPAN.second { COLOR: #000 } .box#natprod FORM { MARGIN: 0px } .box#natprod DIV.natprodmore { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 1em; MARGIN: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .box#natprod DIV.natprodmore INPUT { FONT-SIZE: 110% } DIV.ad-rh { FONT-SIZE: 110%; MARGIN: 0px 0px 20px; COLOR: #d6d6d6; TEXT-ALIGN: = center } DIV.ad-rh P { MARGIN: 0px } DIV.wide.skyscraper.ad-rh { TEXT-TRANSFORM: uppercase } DIV.masthead.ad-rh { BACKGROUND: url(/naturedotcom/images/graphics/bg.ad.masthead.gif) = #f3f3f3 no-repeat 50% 0px } DIV.ad-rh IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: bottom; BORDER-RIGHT-WIDTH: 0px } DIV.ad-rh EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: bottom; BORDER-RIGHT-WIDTH: 0px } DIV.wide.skyscraper.ad-rh IMG { MAX-WIDTH: 160px! important; MARGIN: 4px 0px 0px; WIDTH: 100% } DIV.wide.skyscraper.ad-rh EMBED { MAX-WIDTH: 160px! important; MARGIN: 4px 0px 0px; WIDTH: 100% } * HTML DIV.wide.skyscraper.ad-rh { MAX-WIDTH: 160px! important; MARGIN-LEFT: auto; OVERFLOW: hidden; = WIDTH: 100%; MARGIN-RIGHT: auto } .page-heading { PADDING-RIGHT: 10px; PADDING-LEFT: 7px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } .page-heading H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 150%! important; = PADDING-BOTTOM: 5px; MARGIN: 0px 3px 1em; PADDING-TOP: 5px } .page-heading H1.series { PADDING-LEFT: 39px; MIN-HEIGHT: 13px } H1.piccie { BACKGROUND: url(/reviews/images/rev.jpg) repeat-x left bottom; = PADDING-BOTTOM: 75px } .page-heading H1.page-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #content DIV.box { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; MARGIN: = 1em 0px; PADDING-TOP: 0px } #content DIV.box H2 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px } #content DIV.box H3 { FONT-SIZE: 110%; MARGIN: 0px 0px 0.5em } #content DIV.box H4 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content DIV.box H5 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content DIV.box H6 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content DIV.box UL LI H2 { FONT-SIZE: 100% } #content DIV.box UL LI H3 { FONT-SIZE: 100% } #content DIV.box UL LI H4 { FONT-SIZE: 100% } #content DIV.box UL LI H5 { FONT-SIZE: 100% } #content DIV.box UL LI H6 { FONT-SIZE: 100% } #content DIV.box H3.emphasize { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 5px; MARGIN: 0px = 0px 1em; PADDING-TOP: 5px } #content DIV.box H3 .label { DISPLAY: block } #content DIV.box P { FONT-SIZE: 110%; MARGIN: 0px 0px 1em; LINE-HEIGHT: 190% } #content DIV.box UL LI P { FONT-SIZE: 100% } #content DIV.box A.pdf:link { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.pdf:visited { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.rss:link { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.visited.rss { PADDING-RIGHT: 3px; MARGIN-TOP: 3px; DISPLAY: block; PADDING-LEFT: = 30px; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 3px; PADDING-TOP: 3px; = TEXT-DECORATION: none } #content DIV.box A.pdf:link { BACKGROUND: url(/reviews/images/icons/pdf.gif) #f5f5f5 no-repeat 10px = 50% } #content DIV.box A.pdf:visited { BACKGROUND: url(/reviews/images/icons/pdf.gif) #f5f5f5 no-repeat 10px = 50% } #content DIV.box A.rss:link { PADDING-LEFT: 45px; BACKGROUND: url(/common/images/icons/rss.gif) = #f5f5f5 no-repeat 10px 50% } #content DIV.box A.visited.rss { PADDING-LEFT: 45px; BACKGROUND: url(/common/images/icons/rss.gif) = #f5f5f5 no-repeat 10px 50% } #content DIV.box A.pdf:hover { COLOR: #cd0033 } #content DIV.box A.pdf:focus { COLOR: #cd0033 } #content DIV.box A.rss:hover { COLOR: #cd0033 } #content DIV.box A.rss:focus { COLOR: #cd0033 } #content DIV.box UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 110%; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 1em; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #content DIV.box UL UL { FONT-SIZE: 100% } #content DIV.box UL LI { PADDING-LEFT: 13px; MARGIN: 0px 0px 0.75em; LINE-HEIGHT: 150% } #content DIV.box OL LI { MARGIN-BOTTOM: 0.75em; LINE-HEIGHT: 150% } #content DIV.box DL DT { FONT-WEIGHT: bold; MARGIN: 0px 0px 0.5em; LINE-HEIGHT: 150% } #content DIV.box DL DD { MARGIN: 0px 0px 1em; LINE-HEIGHT: 150% } #content DIV.box UL.action-list LI { BACKGROUND: url(/common/images/icons/next.gif) no-repeat 0px 0.4em } * HTML #content DIV.box UL.anchor-list { MAX-WIDTH: 50em; MARGIN-LEFT: auto; MARGIN-RIGHT: auto } #content DIV.box UL.anchor-list:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #content DIV.box UL.anchor-list { HEIGHT: 1% } #content DIV.box UL.anchor-list LI { PADDING-RIGHT: 1%; PADDING-LEFT: 4%; FLOAT: left; MARGIN-BOTTOM: 0.5em; = PADDING-BOTTOM: 5px; WIDTH: 43%; LINE-HEIGHT: 100%; PADDING-TOP: 5px } #content DIV.box UL.anchor-list LI.even { FLOAT: right } #content DIV.box OL.conference-list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 1em; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #content DIV.box OL.conference-list OL { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; MARGIN: = 0px 0px 1em; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #content DIV.box OL.conference-list H4 { FONT-SIZE: 110%; MARGIN: 0px } #content DIV.box OL.conference-list H5 { FONT-SIZE: 110%; MARGIN: 0px } #content DIV.box OL.conference-list P { FONT-SIZE: 110%; MARGIN: 0px } #content DIV.box OL.conference-list H3 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; = PADDING-BOTTOM: 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px } #content DIV.box OL.conference-list P.date { FONT-WEIGHT: bold } #content DIV.box OL.conference-list H4 { FONT-WEIGHT: normal } #content DIV.box OL.conference-list H5 { FONT-WEIGHT: normal; MARGIN: 0px 0px 1em } #content DIV.box OL.conference-list .no-label H4 { FONT-WEIGHT: normal; MARGIN: 0px 0px 1em } #content DIV.box DL.faq-list DT { PADDING-LEFT: 20px; MIN-HEIGHT: 13px } #content DIV.box DL.faq-list DD { PADDING-LEFT: 20px; MIN-HEIGHT: 13px } #content DIV.box DL.faq-list UL.options { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } #content DIV.box .illustrated { BACKGROUND-POSITION: left top; BACKGROUND-REPEAT: no-repeat } #content DIV.box .size64px.illustrated { PADDING-LEFT: 74px } #content DIV.box .size70px.illustrated { PADDING-LEFT: 80px } #content DIV.box .size76px.illustrated { PADDING-LEFT: 86px } #content DIV.box .size80px.illustrated { PADDING-LEFT: 90px } #content DIV.box .size86px.illustrated { PADDING-LEFT: 96px } #content DIV.box .size116px.illustrated { PADDING-LEFT: 126px } #content DIV.box .size150px.illustrated { PADDING-LEFT: 160px } #content DIV.box H3.address-type-heading { FONT-SIZE: 110%; MARGIN: 0px } #content DIV.box H4.address-type-heading { FONT-SIZE: 110%; MARGIN: 0px } #content DIV.box H5.address-type-heading { FONT-SIZE: 110%; MARGIN: 0px } #content DIV.box H6.address-type-heading { FONT-SIZE: 110%; MARGIN: 0px } #content DIV.box H3.post.address-type-heading { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } #content DIV.box H4.post.address-type-heading { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } #content DIV.box H5.post.address-type-heading { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } #content DIV.box H6.post.address-type-heading { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } #content DIV.box ADDRESS { FONT-SIZE: 110%; MARGIN: 0px 0px 1em; LINE-HEIGHT: 150%; FONT-STYLE: = normal } #content DIV.box ADDRESS .line { DISPLAY: block } #content DIV.box ADDRESS .addressee { FONT-WEIGHT: bold } #content DIV.box ADDRESS .postcode { TEXT-TRANSFORM: uppercase } #content DIV.box ADDRESS .country { TEXT-TRANSFORM: uppercase } .separator { CLEAR: both; PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .box .separator { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .separator HR { DISPLAY: none } TABLE.data { MARGIN: 0px 0px 1em; BORDER-COLLAPSE: collapse } TABLE.data CAPTION { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; FONT-STYLE: normal; TEXT-ALIGN: = left } TABLE.data THEAD TH { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; TEXT-ALIGN: left } TABLE.data THEAD TD { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; TEXT-ALIGN: left } TABLE.data TBODY TH { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; TEXT-ALIGN: left } TABLE.data TBODY TD { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; TEXT-ALIGN: left } TABLE.data TFOOT TD { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; TEXT-ALIGN: left } TABLE.data TFOOT TD UL LI { FONT-SIZE: 90% } #article H1.page-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #article #content DIV.box #atl { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 160%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = BORDER-RIGHT-WIDTH: 0px } #article #content DIV.box #abs { FONT-WEIGHT: bold; MARGIN-BOTTOM: 2em } #article #content DIV.box SUP { FONT-SIZE: 100% } #article #content DIV.box H3 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 5px; MARGIN: 0px = 0px 1em; PADDING-TOP: 5px } #article #content DIV.box H4 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 5px; MARGIN: 0px = 0px 1em; PADDING-TOP: 5px } #article #content DIV.box IMG.valign-middle.char-img { VERTICAL-ALIGN: middle } #article #content DIV.box IMG.valign-bottom.char-img { VERTICAL-ALIGN: bottom } #article #content DIV.box DIV.figure-table { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; MARGIN: = 0px 0px 1em; PADDING-TOP: 10px } #article #content DIV.box DIV.figure-table H5 { MARGIN: 0px 0px 10px } #article #content DIV.box DIV.figure-table IMG.thumb { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px 10px 10px 0px; BORDER-RIGHT-WIDTH: = 0px } #article #content DIV.box DIV.figure-table P { MARGIN-LEFT: 160px } #article #content DIV.box DIV.figure-table UL.options { MARGIN-LEFT: 160px } #article #content DIV.box DIV.box.figure-table P { MARGIN-LEFT: 0px } #article #content DIV.box DIV.box.figure-table UL.options { MARGIN-LEFT: 0px } #article #content DIV.box DIV.figure-table UL.options LI.full { PADDING-LEFT: 25px } #article #content DIV.box DIV.figure-table UL.options LI.fti { PADDING-LEFT: 25px } #article #content DIV.box DIV.figure-table UL.options LI.high-res { PADDING-LEFT: 25px } #article #content DIV.box DIV.figure-table UL.options LI.powerpoint { PADDING-LEFT: 25px } #article #content DIV.box DIV.figure-table UL.options LI.chemdraw { PADDING-LEFT: 25px } #article #content DIV.image-legend { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 1px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 1px; BACKGROUND: #fff; FLOAT: right; = PADDING-BOTTOM: 1px; MARGIN: 10px 0px 10px 10px; BORDER-LEFT: #ccc 1px = solid; WIDTH: 180px! important; PADDING-TOP: 1px; BORDER-BOTTOM: #ccc = 1px solid; TEXT-ALIGN: center } #article #content DIV.image-legend P { PADDING-RIGHT: 5px; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 5px; = FONT-SIZE: 100%; PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: 5px; = TEXT-ALIGN: left } #article #content DIV.image-legend IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 180px; VERTICAL-ALIGN: bottom; BORDER-RIGHT-WIDTH: 0px } #article #content DIV.image-legend SPAN { FONT-STYLE: italic } #article #content P.beforeimage-full { MARGIN-BOTTOM: 1em } #article #content DIV.image-full { PADDING-RIGHT: 10px; MARGIN-TOP: 0px; PADDING-LEFT: 10px; FONT-SIZE: = 100%; BACKGROUND: #fff; PADDING-BOTTOM: 10px; PADDING-TOP: 10px; = TEXT-ALIGN: center } #article #content DIV.image-full IMG { PADDING-RIGHT: 1px; PADDING-LEFT: 1px; MAX-WIDTH: 425px; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } #article #content DIV.image-full P { TEXT-ALIGN: left } #article #content DIV.image-full SPAN { FONT-STYLE: italic } #article #content UL.switch-article-view { MARGIN-BOTTOM: 2em } #article #content UL.switch-article-view LI { PADDING-LEFT: 0px; BACKGROUND-IMAGE: none; MARGIN-LEFT: 0px; COLOR: = #f00 } #article #content UL.switch-article-view LI A:link { FONT-WEIGHT: bold } #article #content UL.switch-article-view LI A:visited { FONT-WEIGHT: bold } #article #extranav #articlenav { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: 1em = 0px; PADDING-TOP: 5px } #article #extranav #articlenav H2 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px } #article #extranav #articlenav UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article #extranav #articlenav UL.view-tools { MARGIN-TOP: 1em; PADDING-TOP: 1em } #article #extranav #articlenav UL LI { PADDING-LEFT: 18px; MARGIN: 0px 0px 0.75em; LINE-HEIGHT: 150% } #article #extranav #articlenav UL.view-tools LI { BACKGROUND: url(/reviews/images/graphics/bullet.arrow-right.9e52a0.gif) = no-repeat 5px 0.6em } #article #extranav #articlenav UL LI A:link { COLOR: #000; TEXT-DECORATION: none } #article #extranav #articlenav UL LI A:visited { COLOR: #000; TEXT-DECORATION: none } #article #extranav #articlenav UL LI A:hover { COLOR: #000; TEXT-DECORATION: underline } #article #extranav #articlenav UL LI A:focus { COLOR: #000; TEXT-DECORATION: underline } #article #extranav #articlenav UL LI.threed { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.fulltext { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.download-pdf { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.sendtofriend { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.export { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.permissions { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.commercial_reprints { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.save { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.toc { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.prev { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.next { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.cited { PADDING-LEFT: 26px } #article #extranav #articlenav UL LI.cited { BACKGROUND: url(/common/images/icons/cited.gif) no-repeat 6px 0px } #article #extranav #search-pubmed { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: 1em = 0px; PADDING-TOP: 5px } #article #extranav #search-pubmed H2 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px } #article #extranav #search-pubmed UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 1em; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article #extranav #search-pubmed LI { PADDING-LEFT: 13px; MARGIN: 0px 0px 0.75em; LINE-HEIGHT: 150% } #article #extranav #search-pubmed LI.more { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND-IMAGE: none; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 10px; BACKGROUND-COLOR: = transparent } #article #extranav #search-pubmed LI.more A:link { PADDING-RIGHT: 0px; PADDING-LEFT: 15px; FONT-SIZE: 100%; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; TEXT-DECORATION: = none } #article #extranav #search-pubmed LI.more A:visited { PADDING-RIGHT: 0px; PADDING-LEFT: 15px; FONT-SIZE: 100%; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; TEXT-DECORATION: = none } #article #extranav #search-pubmed LI.more A:hover { TEXT-DECORATION: underline } #article #extranav #search-pubmed LI.more A:focus { TEXT-DECORATION: underline } #article #content DIV.poster.box IMG.poster-graphic { PADDING-RIGHT: 1px; DISPLAY: block; PADDING-LEFT: 1px; FLOAT: left; = PADDING-BOTTOM: 1px; MARGIN: 0px 10px 10px 0px; PADDING-TOP: 1px } #article #content DIV.nature-view.box #articlebody { MARGIN-TOP: 2em; MARGIN-BOTTOM: 2em } #article #content DIV.in-brief.box #articlebody DIV H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 1em 0px; PADDING-TOP: = 0px } #article #content DIV.in-brief.box #articlebody DIV H3 SPAN.label { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; FONT-SIZE: = 120%; BACKGROUND: #fff; PADDING-BOTTOM: 3px; COLOR: #8a8c9f; = PADDING-TOP: 3px; BORDER-BOTTOM: #e3e3e3 1px solid } #article #content DIV.in-brief.box #articlebody DIV H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: normal; FONT-SIZE: = 125%; BACKGROUND: none transparent scroll repeat 0% 0%; PADDING-BOTTOM: = 0px; MARGIN: 1em 0px 0px; LINE-HEIGHT: 150%; PADDING-TOP: 0px } #article #content DIV.in-brief.box #articlebody DIV P.aug { MARGIN: 0.5em 0px 0px; COLOR: #666 } #article #content DIV.in-brief.box #articlebody DIV.in-brief-item { MARGIN-BOTTOM: 3em } #article #content DIV.news-in-brief.box #articlebody = DIV.news-in-brief-item { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 10px; BACKGROUND: #f5f5f5; = MARGIN-BOTTOM: 2em; PADDING-BOTTOM: 10px; BORDER-LEFT: #e7e7e7 1px = solid; PADDING-TOP: 10px; BORDER-BOTTOM: #e7e7e7 1px solid } #article #content DIV.news-in-brief.box #articlebody = DIV.news-in-brief-item H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #article #content #more-like-this { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: 25px 0px; = BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #ccc 1px = solid } #article #content #more-like-this H3 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 3px; MARGIN: 0px; PADDING-TOP: 3px; BACKGROUND-COLOR: = #f6f6f6 } #article #content #more-like-this DIV.wrapper { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 0px } #article #content #more-like-this P.explain { MARGIN: 10px } #article #content #more-like-this A.article { DISPLAY: block; FONT-WEIGHT: bold; MARGIN: 0px; COLOR: #666 } #article #content #more-like-this A.article:hover { COLOR: #c03 } #article #content #more-like-this P.journal { MARGIN: 0px; FONT-STYLE: italic } #article #content #more-like-this P.journal SPAN { FONT-STYLE: normal } #article #content #more-like-this H4.area { PADDING-LEFT: 0px; MARGIN: 0px; TEXT-TRANSFORM: uppercase; COLOR: #000; = BACKGROUND-COLOR: transparent } #article #content #more-like-this A.allmatches:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/c03/arrow_s.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #c03; PADDING-TOP: 0px } #article #content #more-like-this A.allmatches:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/c03/arrow_s.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #c03; PADDING-TOP: 0px } #article #content #more-like-this A.allmatches:hover { BACKGROUND: url(/common/images/icons/c03/arrow_s.gif) no-repeat left = center } #article-related P.journal { FONT-STYLE: normal } #article-related P.journal SPAN.journalname { FONT-STYLE: italic } #article-related H1.page-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 110%; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.box H2.from { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.box .container-cite H2.note { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.box .container-cite P { FONT-SIZE: 110%; MARGIN: 0px } #article-related DIV.box .container-cite P.atl { FONT-WEIGHT: bold } #article-related DIV.box .container-image { BORDER-BOTTOM-WIDTH: 0px } #article-related DIV.box .container-image-text { BORDER-TOP-WIDTH: 0px! important } #article-related DIV.box .container-image-text P { FONT-SIZE: 110% } #article-related DIV.ar-navigation { MARGIN: 1em auto; TEXT-ALIGN: center } #article-related DIV.align-left.ar-navigation { TEXT-ALIGN: left } #article-related DIV.ar-navigation UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article-related DIV.ar-navigation UL LI { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #article-related DIV.ar-navigation UL LI.back { PADDING-LEFT: 8px } #article-related DIV.ar-navigation UL LI.down { PADDING-LEFT: 8px } #article-related DIV.ar-navigation UL LI.next { PADDING-RIGHT: 8px; PADDING-LEFT: 0px } #article-related DIV.container-figtab { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-figtab DIV.container-image-text H3 { FONT-SIZE: 110% } #article-related DIV.container-figtab DIV.container-image-text P { FONT-SIZE: 110% } #article-related DIV.container-figtab DIV.container-image-text { MARGIN-LEFT: 164px } #article-related DIV.container-figtab DIV.container-image A IMG { PADDING-RIGHT: 1px; PADDING-LEFT: 1px; PADDING-BOTTOM: 1px; = PADDING-TOP: 1px } #article-related DIV.container-figtab UL.options { MARGIN-BOTTOM: 0px } #article-related DIV.container-figtab UL.options LI { MARGIN-BOTTOM: 0px } #article-related DIV.container-figtab UL.options { PADDING-BOTTOM: 1em } #article-related DIV.container-figtab UL.options LI { LINE-HEIGHT: 150% } #article-related DIV.container-figtab UL.options LI.full { PADDING-LEFT: 25px } #article-related DIV.container-image-text UL.options LI.full { PADDING-LEFT: 25px } #article-related DIV.container-figtab UL.options LI.powerpoint { PADDING-LEFT: 25px } #article-related DIV.container-image-text UL.options LI.powerpoint { PADDING-LEFT: 25px } #article-related DIV.container-figtab UL.options LI.chemdraw { PADDING-LEFT: 25px } #article-related DIV.container-image-text UL.options LI.chemdraw { PADDING-LEFT: 25px } #article-related DIV.box .container-table { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; TEXT-ALIGN: center } #article-related DIV.box .container-image-box { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; TEXT-ALIGN: center } #article-related H2#figure-title { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 130%; BACKGROUND: none transparent scroll repeat 0% 0%; PADDING-BOTTOM: = 0px; MARGIN: 1em 0px; TEXT-TRANSFORM: none; COLOR: black; PADDING-TOP: = 0px; BORDER-BOTTOM-STYLE: none } #article-related TABLE.data { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-COLLAPSE: collapse; BORDER-RIGHT-WIDTH: 0px } #article-related TABLE.data TR { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #article-related TABLE.data THEAD TH { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 9px; PADDING-LEFT: 9px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 7px; PADDING-TOP: 7px; BORDER-RIGHT-WIDTH: 0px } #article-related TABLE.data TFOOT TD { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 7px; PADDING-TOP: 7px; BORDER-RIGHT-WIDTH: 0px } #article-related TABLE.data TBODY TR { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #article-related TABLE.data TBODY TR.odd { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #article-related TABLE.data TBODY TH { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; BORDER-RIGHT-WIDTH: 0px } #article-related TABLE.data TBODY TD { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; BACKGROUND: none transparent = scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.box DIV.send-friend-wrapper { MARGIN: 6em 0px; TEXT-ALIGN: center } #article-related DIV.box DIV.container-sendfriend { CLEAR: both; MAX-WIDTH: 53em; MARGIN: 0px auto } #article-related DIV.box DIV.container-sendfriend DIV.wrapper { MARGIN-BOTTOM: 10px } #article-related DIV.box DIV.container-sendfriend LABEL { FONT-WEIGHT: normal; FONT-SIZE: 110% } #article-related DIV.box DIV.container-sendfriend P { FONT-SIZE: 100%; MARGIN: 0px } #article-related DIV.box DIV.container-sendfriend DIV.text { FLOAT: left; WIDTH: 210px; TEXT-ALIGN: right } #article-related DIV.box DIV.container-sendfriend DIV.form { MARGIN-LEFT: 220px } #article-related DIV.box DIV.container-sendfriend DIV.form INPUT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.box DIV.container-sendfriend DIV.form TEXTAREA { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.box DIV.container-sendfriend DIV.form INPUT { WIDTH: 100% } #article-related DIV.box DIV.container-sendfriend DIV.form TEXTAREA { WIDTH: 100% } #article-related DIV.box DIV.container-sendfriend INPUT.friend { CLEAR: both; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: = 3px; FONT: bold 110% Verdana, Arial, Helvetica, sans-serif; MARGIN-LEFT: = 55px; PADDING-TOP: 3px } #article-related DIV.box H2.author { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 1em 0px 0px; = PADDING-TOP: 0px } #article-related DIV.box H2.glossary-term { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 110%; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 1em = 0px 0px; TEXT-TRANSFORM: none; COLOR: black; PADDING-TOP: 0px; = BORDER-BOTTOM-STYLE: none } #article-related DIV.container-supplementary DIV.wrapper { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px 0px 1em; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-supplementary DIV.wrapper H2 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN: 0px 0px 0.5em; = TEXT-TRANSFORM: none; COLOR: black; BORDER-BOTTOM-STYLE: none } #article-related DIV.container-supplementary DIV.wrapper P { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px 0px 1em; LINE-HEIGHT: 150%; PADDING-TOP: 0px; = BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-supplementary DIV.wrapper P.links { MARGIN: 0px } #article-related #browser-plugins { CLEAR: both; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: = 10px; PADDING-TOP: 10px } #article-related #browser-plugins H2 { FONT-SIZE: 110%; MARGIN: 0px } #article-related #browser-plugins H3 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #article-related #browser-plugins DIV { FLOAT: left; MARGIN-LEFT: 3%; WIDTH: 30% } #article-related #browser-plugins DIV.cleardiv { FLOAT: none; MARGIN: 0px; WIDTH: auto } #article-related #browser-plugins DIV.first { MARGIN-LEFT: 0px } #article-related #browser-plugins UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #toc #content DIV.box H4 { MARGIN-TOP: 0.5em } #toc #content DIV.box H5 { MARGIN-TOP: 0.5em } #toc #content DIV.box H6 { MARGIN-TOP: 0.5em } #toc #content DIV.issue DIV.details { FLOAT: right; WIDTH: 48% } #toc #content DIV.issue DIV.details H2 { BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; COLOR: #000 } #toc #content DIV.issue DIV.details SPAN.label { DISPLAY: block } #toc #content DIV.issue DIV.cover-navigation { FLOAT: left; WIDTH: 48% } #toc #content DIV.issue DIV.cover-navigation P.previous-issue { PADDING-RIGHT: 3px; PADDING-LEFT: 11px; PADDING-BOTTOM: 5px; = LINE-HEIGHT: 100%; PADDING-TOP: 5px } #toc #content DIV.issue DIV.cover-navigation IMG.journal-cover { PADDING-RIGHT: 1px; DISPLAY: block; PADDING-LEFT: 1px; PADDING-BOTTOM: = 1px; PADDING-TOP: 1px } #toc #content DIV.issue DIV.cover-navigation P.about-cover { PADDING-LEFT: 18px } #toc #content DIV.section { MARGIN: 0px 0px 1em } #toc #content DIV.section .article { MARGIN: 0px 0px 2em } #toc #content DIV.section H3 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px } #toc #content DIV.section H4.atl { FONT-SIZE: 110%; MARGIN: 1ex 0px 0px } #toc #content DIV.section P.aug { FONT-SIZE: 110%; MARGIN: 0px; LINE-HEIGHT: 150%; FONT-STYLE: italic } #toc #content DIV.section P.date { FONT-SIZE: 110%; MARGIN: 0px; LINE-HEIGHT: 150% } #toc #content DIV.section P.page { FONT-SIZE: 110%; MARGIN: 0px 0px 0.5em; LINE-HEIGHT: 150% } #toc #content DIV.section P.doi { FONT-SIZE: 110%; MARGIN: 0px 0px 0.5em; LINE-HEIGHT: 150% } #toc #content DIV.section UL.article-views { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.5em 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #toc #content DIV.section UL.article-views:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #toc #content DIV.section UL.article-views { HEIGHT: 1% } #toc #content DIV.section UL.article-views LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0.5em; MIN-HEIGHT: 12px; FLOAT: left; = BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 0.5em; = LINE-HEIGHT: 100%; PADDING-TOP: 0px } #toc #content DIV.section UL.article-views LI.first { PADDING-LEFT: 18px; BORDER-LEFT-WIDTH: 0px; MARGIN-LEFT: 0px } #toc #content DIV.section UL.article-views LI.pdf { FONT-WEIGHT: bold } #toc #content DIV.section P.see-also { PADDING-LEFT: 18px } #toc #content P.seealso { FONT-SIZE: 90% } #toc #content SPAN.seealso-title { PADDING-LEFT: 18px; FONT-WEIGHT: bold; BACKGROUND: = url(/nrg/images/graphics/bullet.arrow-right.image.gif) no-repeat left = center } #toc #content DIV.section DIV.type H4 { FONT-SIZE: 110%; MARGIN: 0px; TEXT-TRANSFORM: uppercase } #toc #content DIV.focus DIV.section DIV.type H5 { FONT-SIZE: 110%; MARGIN: 0px; TEXT-TRANSFORM: uppercase } #toc #content DIV.section DIV.series DIV.type H5 { FONT-SIZE: 110%; MARGIN: 0px; TEXT-TRANSFORM: uppercase } #toc #content DIV.section DIV.type .article { PADDING-LEFT: 15px } #toc #content DIV.section DIV.topic H4 { FONT-SIZE: 100%; MARGIN: 1em 0px } #toc #content DIV.section DIV.topic H4 SPAN.label { PADDING-RIGHT: 8px; PADDING-LEFT: 8px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } #toc #content DIV.section DIV.topic H4 SPAN.focus { PADDING-RIGHT: 45px; MIN-HEIGHT: 13px } #toc #content DIV.section DIV.topic .article { =09 } #toc #content DIV.focus H3 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px; PADDING-TOP: 5px } #toc #content DIV.focus H3 A:link { TEXT-DECORATION: none } #toc #content DIV.focus H3 A:visited { TEXT-DECORATION: none } #toc #content DIV.focus H3 SPAN.focus { PADDING-LEFT: 18px; MIN-HEIGHT: 13px } #toc #content DIV.focus DIV.section { MARGIN: 0px } #toc #content DIV.focus DIV.section H4 { PADDING-RIGHT: 14px; PADDING-LEFT: 14px; FONT-SIZE: 110%; = PADDING-BOTTOM: 6px; MARGIN: 0px 0px 1em; PADDING-TOP: 6px } #toc #content DIV.focus DIV.section DIV.series { =09 } #toc #content DIV.focus DIV.section DIV.type { =09 } #toc #content DIV.focus DIV.section DIV.series H5 { FONT-SIZE: 110%; MARGIN: 0px } #toc #content DIV.focus DIV.section DIV.series H5 { PADDING-LEFT: 5px } #toc #content DIV.focus DIV.section DIV.type H5 { PADDING-LEFT: 5px } #toc #content DIV.focus DIV.section DIV.series H5 SPAN.series { PADDING-LEFT: 29px; MIN-HEIGHT: 13px } #toc #content DIV.focus DIV.section DIV.series DIV.article { PADDING-LEFT: 14px } #toc #content DIV.focus DIV.section DIV.type DIV.article { PADDING-LEFT: 14px } #toc #content DIV.section DIV.series H4 { FONT-SIZE: 110%; MARGIN: 0px 0px 0.5em } #toc #content DIV.section DIV.series H4 SPAN.series { PADDING-LEFT: 29px; MIN-HEIGHT: 13px } #toc #content DIV.orphan.section DIV.article H3 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 110%; BACKGROUND: none transparent = scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; TEXT-TRANSFORM: none; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: = 0px } #toc #content DIV.orphan.section DIV.type { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 8px; MARGIN: 0px = 0px 1em; PADDING-TOP: 8px } #toc #content DIV.orphan.section DIV.type H4 { PADDING-LEFT: 5px } #toc #content DIV.orphan.section DIV.type .article { MARGIN-LEFT: 0px } #toc #content DIV.orphan.section DIV.type .article { MARGIN-LEFT: 0px } #toc #content DIV.archive-calendar UL { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; PADDING-BOTTOM: 10px; MARGIN: = 0px; PADDING-TOP: 10px; LIST-STYLE-TYPE: none } #toc #content DIV.archive-calendar UL LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0px; LINE-HEIGHT: 100%; = PADDING-TOP: 0px } #toc #content DIV.archive-calendar UL LI:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #toc #content DIV.archive-calendar UL LI { HEIGHT: 1% } #toc #content DIV.archive-calendar UL UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #toc #content DIV.archive-calendar UL UL LI { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0.5em; FONT-WEIGHT: = normal; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0.5em 0px 0.5em 0.5em; = PADDING-TOP: 0px } #toc #content DIV.archive-calendar UL UL LI.first { PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; MARGIN-LEFT: 0px } #toc #content #archiveMonths H2 { PADDING-RIGHT: 1em; PADDING-LEFT: 1em; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 1em } #toc #content #archiveMonths DIV.spacing { MARGIN-BOTTOM: 1em; PADDING-BOTTOM: 1em } #toc #content #archiveMonths UL { PADDING-RIGHT: 1em; PADDING-LEFT: 1em; PADDING-BOTTOM: 1em; MARGIN: = 0px; PADDING-TOP: 1em; LIST-STYLE-TYPE: none } #toc #content #archiveMonths UL:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #toc #content #archiveMonths UL { HEIGHT: 1% } #toc #content #archiveMonths UL LI { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0.5em; FONT-WEIGHT: = normal; BACKGROUND: none transparent scroll repeat 0% 0%; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0.5em 0px 0px 0.5em; LINE-HEIGHT: 100%; = PADDING-TOP: 0px } * HTML #toc #content #archiveMonths UL LI { LINE-HEIGHT: 110% } #toc #content #archiveMonths UL LI.first { PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; MARGIN-LEFT: 0px } #toc #content #archiveArticles A.backtotop:link { FLOAT: right; MARGIN: 5px 3px } #toc #content #archiveArticles A.backtotop:visited { FLOAT: right; MARGIN: 5px 3px } #toc #content #archiveArticles H3 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px; PADDING-TOP: 5px } #toc #content #archiveArticles H4.type { FONT-SIZE: 110%; MARGIN: 0px; TEXT-TRANSFORM: uppercase; COLOR: #999 } #toc #content #archiveArticles DIV.spacing { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #toc #content #archiveArticles DIV.spacing P.aug { MARGIN: 0px; LINE-HEIGHT: 150%; FONT-STYLE: italic } #toc #content #archiveArticles DIV.spacing P.doi { FONT-SIZE: 110%; MARGIN: 0px 0px 0.5em; LINE-HEIGHT: 150% } #toc #content #archiveArticles DIV.spacing UL.article-views:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #toc #content #archiveArticles DIV.spacing UL.article-views { HEIGHT: 1% } #toc #content #archiveArticles DIV.spacing UL.article-views LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0.5em; MIN-HEIGHT: 12px; FLOAT: left; = BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 0.5em; = LINE-HEIGHT: 100%; PADDING-TOP: 0px } #toc #content #archiveArticles DIV.spacing UL.article-views LI.first { PADDING-LEFT: 18px; BORDER-LEFT-WIDTH: 0px; MARGIN-LEFT: 0px } #toc #content #archiveArticles DIV.spacing UL.article-views LI.pdf { FONT-WEIGHT: bold } #archive #content DIV.archive-views { MARGIN-BOTTOM: 1em; PADDING-BOTTOM: 1em } #archive #content DIV.archive-views H2 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1em; PADDING-LEFT: 1em; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN: 1em 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #archive #content DIV.archive-views UL { PADDING-RIGHT: 1em; PADDING-LEFT: 1em; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #archive #content DIV.archive-views UL:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #archive #content DIV.archive-views UL { HEIGHT: 1% } #archive #content DIV.archive-views UL LI { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0.5em; FONT-WEIGHT: = normal; BACKGROUND: none transparent scroll repeat 0% 0%; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0.5em 0px 0px 0.5em; LINE-HEIGHT: 100%; = PADDING-TOP: 0px } * HTML #archive #content DIV.archive-views UL LI { LINE-HEIGHT: 110% } #archive #content DIV.archive-views UL LI.first { PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; MARGIN-LEFT: 0px } #archive #content UL.vol { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #archive #content UL.vol:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } #archive #content UL.vol LI { PADDING-RIGHT: 3px; PADDING-LEFT: 0px; FLOAT: left; BACKGROUND-IMAGE: = none; PADDING-BOTTOM: 0px; PADDING-TOP: 10px } #archive #content UL.vol DIV { FONT-SIZE: 100%; WIDTH: 131px } #archive #content UL.vol .month { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-WEIGHT: normal; FONT-SIZE: = 100%; PADDING-BOTTOM: 2px; MARGIN: 0px; PADDING-TOP: 1px } #archive #content DIV.box UL.vol .issue-no { PADDING-RIGHT: 4px; DISPLAY: block; PADDING-LEFT: 4px; FONT-SIZE: 90%; = PADDING-BOTTOM: 2px; PADDING-TOP: 1px } * HTML #archive #content UL.vol .issue-image { MARGIN-BOTTOM: 0px; HEIGHT: 170px } #archive #content UL.vol .issue-image { DISPLAY: block; FONT-SIZE: 90%; MARGIN: 0px auto; WIDTH: 130px; HEIGHT: = 170px; TEXT-ALIGN: center } #archive #content UL.vol .supname { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; PADDING-BOTTOM: 2px; MARGIN: = 0px; PADDING-TOP: 1px } #archive #content UL.vol .pagerange { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-SIZE: 90%; PADDING-BOTTOM: = 2px; MARGIN: 0px; PADDING-TOP: 1px } #archive #content UL.vol .noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #archive #subject-category UL.subject-category { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #archive #subject-category UL.subject-category LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND-IMAGE: none; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #archive #subject-category UL.subject-category LI H3 { DISPLAY: inline } #archive #subject-category UL.subject-category LI UL.year { DISPLAY: inline } #archive #subject-category UL.subject-category LI UL.year LI { DISPLAY: inline } #archive #subject-category UL.subject-category LI H3 { MARGIN-RIGHT: 1em } #archive #web-focuses DIV.supp { MARGIN: 0px 0px 1em } #archive #web-focuses DIV.supp IMG { PADDING-RIGHT: 1px; DISPLAY: block; PADDING-LEFT: 1px; FLOAT: left; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } #archive #web-focuses DIV.supp H3 { MARGIN-LEFT: 90px } #archive #web-focuses DIV.supp H4 { MARGIN-LEFT: 90px } #archive #web-focuses DIV.supp P { MARGIN-LEFT: 90px } #archive #web-focuses DIV.supp H3.type { MARGIN-BOTTOM: 0.5em; TEXT-TRANSFORM: uppercase } #archive #web-focuses DIV.supp H4.atl { MARGIN-TOP: 0px; FONT-WEIGHT: normal; MARGIN-BOTTOM: 0.5em } #archive #web-focuses DIV.supp H4.atl SPAN.updated { PADDING-LEFT: 1em; TEXT-TRANSFORM: lowercase } #archive #web-focuses DIV.supp P.date { MARGIN-BOTTOM: 0px; LINE-HEIGHT: 100% } #archive #web-focuses DIV.supp P.support { MARGIN-BOTTOM: 0px; LINE-HEIGHT: 150%; FONT-STYLE: italic } #archive #posters DIV.supp { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; PADDING-BOTTOM: 15px; = PADDING-TOP: 15px } #archive #posters DIV.supp H2.atl { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 90px; = PADDING-TOP: 0px } #archive #posters DIV.supp IMG { PADDING-RIGHT: 1px; DISPLAY: block; PADDING-LEFT: 1px; FLOAT: left; = PADDING-BOTTOM: 1px; PADDING-TOP: 1px } #archive #posters DIV.supp H2 { MARGIN-LEFT: 90px } #archive #posters DIV.supp P { MARGIN-LEFT: 90px } #archive #posters DIV.supp P.aug { MARGIN-BOTTOM: 0.5em; LINE-HEIGHT: 150% } #archive #posters DIV.supp P.description { MARGIN-BOTTOM: 0px; LINE-HEIGHT: 150% } #archive #posters DIV.supp P.date { MARGIN-BOTTOM: 0px; LINE-HEIGHT: 150% } #archive #posters DIV.supp P.support { MARGIN-BOTTOM: 0px; FONT-STYLE: italic } #toc #content DIV.article P.correspondence { MARGIN: 1em 0px; LINE-HEIGHT: 150% } DIV.reg-rec UL.toc-pdf { MARGIN: 0px } DIV.reg-rec UL.toc-pdf LI { MARGIN: 10px 0px 0px } #toc #content DIV.cover-navigation UL.prev-next { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #toc #content DIV.cover-navigation UL.prev-next:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #toc #content DIV.cover-navigation UL.prev-next { HEIGHT: 1% } #toc #content DIV.cover-navigation UL.prev-next LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 34%; PADDING-TOP: 0px } #toc #content DIV.cover-navigation UL.prev-next LI A:link { PADDING-RIGHT: 8px; DISPLAY: block; PADDING-LEFT: 8px; PADDING-BOTTOM: = 3px; PADDING-TOP: 3px } #toc #content DIV.cover-navigation UL.prev-next LI A:visited { PADDING-RIGHT: 8px; DISPLAY: block; PADDING-LEFT: 8px; PADDING-BOTTOM: = 3px; PADDING-TOP: 3px } #toc #content DIV.cover-navigation UL.prev-next LI.next A:link { TEXT-ALIGN: right } #toc #content DIV.cover-navigation UL.prev-next LI.next A:visited { TEXT-ALIGN: right } #toc #content #archiveMonths H2 { BORDER-BOTTOM-WIDTH: 0px! important } #subscribe-now #content DIV.container { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 2em; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #subscribe-now #content DIV.container DIV.column1 { PADDING-RIGHT: 1%; FLOAT: left; WIDTH: 48% } #subscribe-now #content DIV.container DIV.column2 { PADDING-LEFT: 1%; FLOAT: right; WIDTH: 48% } #subscribe-now #content .button { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 100%; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif } #subscribe-now #content DIV.box DIV.container .button { FONT-SIZE: 110% } #subscribe-now #content DIV.container P { MARGIN-BOTTOM: 0.5em } #subscribe-now #content DIV.container H2 { MARGIN-TOP: 0px; TEXT-TRANSFORM: none; COLOR: #000; = BORDER-BOTTOM-STYLE: none } #subscribe-now #content DIV.container H3.first { MARGIN-TOP: 0px } #subscribe-now #content DIV.container A.register { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; TEXT-DECORATION: none } #subscribe-now #content DIV.container SPAN.freeaccount { FONT-WEIGHT: bold } #about-cover #content DIV.coverimage { PADDING-RIGHT: 10px; MARGIN-TOP: 1em; PADDING-LEFT: 10px; = BORDER-BOTTOM-WIDTH: 0px! important; PADDING-BOTTOM: 10px; PADDING-TOP: = 10px; TEXT-ALIGN: center } #about-cover #content DIV.coverimage IMG { PADDING-RIGHT: 1px; PADDING-LEFT: 1px; PADDING-BOTTOM: 1px; WIDTH: = 100%; PADDING-TOP: 1px } #about-cover #content DIV.covertext { BORDER-TOP-WIDTH: 0px! important; PADDING-RIGHT: 10px; PADDING-LEFT: = 10px; MARGIN-BOTTOM: 2em; PADDING-BOTTOM: 10px; PADDING-TOP: 10px; = TEXT-ALIGN: left } #about-cover #content DIV.covertext P { MARGIN: 1em 0px 0px } #about-cover #content DIV.covertext P .image-title { FONT-STYLE: italic } #article #content DIV.box OL.twenty-questions LI { FONT-WEIGHT: bold } #article #content DIV.box OL.twenty-questions UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article #content DIV.box OL.twenty-questions UL LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: normal; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; PADDING-TOP: = 0px } #article #content DIV.box OL.twenty-questions UL LI H6 A:link { DISPLAY: block; PADDING-LEFT: 18px; MIN-HEIGHT: 12px } #article #content DIV.box OL.twenty-questions UL LI H6 A:visited { DISPLAY: block; PADDING-LEFT: 18px; MIN-HEIGHT: 12px } #article #content DIV.web-watch UL.web-watch-links { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #article #content DIV.web-watch UL.web-watch-links LI A:link { FONT-WEIGHT: bold } #article #content DIV.web-watch UL.web-watch-links LI A:visited { FONT-WEIGHT: bold } #article #content DIV.disease-watch #articlebody DIV.item { MARGIN: 0px 0px 1em } #article #content DIV.disease-watch #articlebody DIV.item H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 20px; PADDING-BOTTOM: 0px; MARGIN: = 1em 0px 0px; PADDING-TOP: 0px } #article #content DIV.disease-watch #articlebody DIV.item P { MARGIN: 0px 0px 0px 20px } #article #content DIV.disease-watch #articlebody DIV.item P.source { FONT-WEIGHT: bold } #article #content DIV.disease-watch #articlebody DIV.item H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 1em 0px 0px 20px; = PADDING-TOP: 0px } #article #content DIV.box H2#atl SPAN.label { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 62.5%; MARGIN: 1em 0px = 0.5em; TEXT-TRANSFORM: uppercase } #article #content DIV.box P.focus { FONT-WEIGHT: bold; FONT-SIZE: 100%; MIN-HEIGHT: 13px; MARGIN: 1em 0px = 0.5em; TEXT-TRANSFORM: uppercase } #article #content DIV.box P.series { FONT-WEIGHT: bold; FONT-SIZE: 100%; MIN-HEIGHT: 13px; MARGIN: 1em 0px = 0.5em; TEXT-TRANSFORM: uppercase } #article #content DIV.box P.focus { PADDING-LEFT: 18px } #article #content DIV.box P.series { PADDING-LEFT: 29px } #article #content DIV.box P.focus A:link { TEXT-TRANSFORM: none } #article #content DIV.box P.focus A:visited { TEXT-TRANSFORM: none } #article #content DIV.box P.series A:link { TEXT-TRANSFORM: none } #article #content DIV.box P.series A:visited { TEXT-TRANSFORM: none } #article #content BLOCKQUOTE.box { FLOAT: right; MARGIN: 0px 0px 10px 10px; WIDTH: 180px! important } #article #content BLOCKQUOTE.box P.quote { MARGIN: 10px } #article #content BLOCKQUOTE.box P.quote-source { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 0px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; FONT-STYLE: italic } #article #content BLOCKQUOTE IMG.quoteleft { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; WIDTH: 12px; MARGIN-RIGHT: 5px; HEIGHT: 10px; BORDER-RIGHT-WIDTH: = 0px } #article #content BLOCKQUOTE IMG.quoteright { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MARGIN-LEFT: 5px; WIDTH: 12px; HEIGHT: 10px; BORDER-RIGHT-WIDTH: = 0px } #article #content #links { MARGIN: 2em 0px } #article #content #links H5 { FONT-SIZE: 100%; MARGIN: 1em 0px 0.5em; TEXT-TRANSFORM: uppercase } #article #content #links H6 { MARGIN: 0px 0px 0px 20px } #article #content #links P { MARGIN-LEFT: 20px } #article #content #links .source { FONT-STYLE: italic } #article #content #links UL { MARGIN: 0px 0px 1em 20px } #article #content #links UL LI { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0.75em; = BORDER-LEFT-WIDTH: 0px! important; BACKGROUND: = url(/reviews/images/link_line.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 0.75em; LINE-HEIGHT: 200%; = PADDING-TOP: 0px } #article #content #links UL LI.first { PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; MARGIN-LEFT: 0px } #article #content #references-links { MARGIN: 2em 0px } #article #content #References { MARGIN: 2em 0px } #article #content #references-links H5 { FONT-SIZE: 100%; MARGIN: 0.5em 0px; TEXT-TRANSFORM: uppercase } #article #content #references-links OL.references { PADDING-RIGHT: 0px; PADDING-LEFT: 30px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #article #content #References OL.references { PADDING-RIGHT: 0px; PADDING-LEFT: 30px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #article #content #references-links OL.references { LIST-STYLE-TYPE: none } * HTML #article #content #references-links OL.references { PADDING-LEFT: 35px } * HTML #article #content #References OL.references { PADDING-LEFT: 35px } #article #content #references-links OL.references LI { LINE-HEIGHT: 125% } #article #content #References OL.references LI { LINE-HEIGHT: 125% } #article #content #references-links OL.references LI P { MARGIN: 0px; LINE-HEIGHT: 125% } #article #content #References OL.references P { MARGIN: 0px; LINE-HEIGHT: 125% } #article #content #references-links OL.references LI P.details { FONT-WEIGHT: normal } #article #content #References OL.references LI P.details { FONT-WEIGHT: normal } #article #content #references-links OL.references LI P.details .author { FONT-WEIGHT: normal } #article #content #References OL.references P.details .author { FONT-WEIGHT: normal } #article #content #references-links OL.references LI UL.article-views { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article #content #References OL.references LI UL.article-views { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article #content #references-links OL.references LI = UL.article-views:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } #article #content #References OL.references LI UL.article-views:unknown = { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #article #content #references-links OL.references LI = UL.article-views { HEIGHT: 1% } * HTML #article #content #References OL.references LI UL.article-views { HEIGHT: 1% } #article #content #references-links OL.references LI UL.article-views LI = { PADDING-RIGHT: 0px; PADDING-LEFT: 1em; FONT-WEIGHT: normal; BACKGROUND: = none transparent scroll repeat 0% 0%; FLOAT: left; PADDING-BOTTOM: 0px; = MARGIN: 0px 0px 0px 1em; LINE-HEIGHT: 100%; PADDING-TOP: 0px } #article #content #References OL.references LI UL.article-views LI { PADDING-RIGHT: 0px; PADDING-LEFT: 1em; FONT-WEIGHT: normal; BACKGROUND: = none transparent scroll repeat 0% 0%; FLOAT: left; PADDING-BOTTOM: 0px; = MARGIN: 0px 0px 0px 1em; LINE-HEIGHT: 100%; PADDING-TOP: 0px } #article #content #references-links OL.references LI UL.article-views = LI.first { BORDER-TOP-WIDTH: 0px; PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN-LEFT: 0px; BORDER-RIGHT-WIDTH: 0px } #article #content #References OL.references LI UL.article-views LI.first = { BORDER-TOP-WIDTH: 0px; PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN-LEFT: 0px; BORDER-RIGHT-WIDTH: 0px } #article #content #affiliations-notes { MARGIN: 2em 0px } #article #content #affiliations-notes OL { PADDING-RIGHT: 0px; PADDING-LEFT: 20px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } * HTML #article #content #affiliations-notes OL { PADDING-LEFT: 25px } #article #content #affiliations-notes OL LI { FONT-WEIGHT: normal; FONT-SIZE: 110% } #article #content #affiliations-notes OL LI LI { FONT-SIZE: 100% } #article #content #prev-next { MARGIN: 2em 0px 0px } #article #content #prev-next UL.prev-next { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article #content #prev-next UL.prev-next:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #article #content #prev-next UL.prev-next { HEIGHT: 1% } #article #content #prev-next UL.prev-next LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px; = WIDTH: 49%; PADDING-TOP: 0px } #article #content #prev-next UL.prev-next LI.next { FLOAT: right } #article #content #prev-next UL.prev-next LI A { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #article #content #prev-next UL.prev-next LI.next A:link { PADDING-RIGHT: 15px; TEXT-ALIGN: right } #article #content #prev-next UL.prev-next LI.next A:visited { PADDING-RIGHT: 15px; TEXT-ALIGN: right } #article #content #prev-next UL.prev-next LI.prev A:link { PADDING-LEFT: 15px } #article #content #prev-next UL.prev-next LI.prev A:visited { PADDING-LEFT: 15px } #article #content P.correspondence { MARGIN: 1em 0px; COLOR: #8a8a8a; LINE-HEIGHT: 150% } #article #content DIV.correspondence P.correspondence { MARGIN: 0px 0px 1.7em } #article H1.page-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #article #content DIV.correspondence.box #parent { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 6px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 6px; FONT-WEIGHT: normal; FONT-SIZE: = 110%; BACKGROUND: #f5f5f5; PADDING-BOTTOM: 8px; TEXT-TRANSFORM: none; = BORDER-LEFT: #e7e7e7 1px solid; COLOR: #000; PADDING-TOP: 8px; = BORDER-BOTTOM: #e7e7e7 1px solid } #article #content DIV.correspondence.box #parent SPAN.label { FONT-WEIGHT: bold } #article #content P.see-also { MARGIN: 1em 0px 0px; COLOR: #c03; LINE-HEIGHT: 150% } #article #content DIV.correspondence.box .corres-title { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 150%; BACKGROUND: = none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; MARGIN: 20px 0px 0px; PADDING-TOP: 0px; = BORDER-RIGHT-WIDTH: 0px } #home #content DIV.details { FLOAT: right; MARGIN-BOTTOM: 2em; WIDTH: 48% } #home #content DIV.details H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = COLOR: #000; PADDING-TOP: 0px } #home #content DIV.details DIV.featured-article { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 7px; MARGIN: = 0px 0px 2em; PADDING-TOP: 7px } #home #content DIV.details DIV.featured-article H3 { TEXT-TRANSFORM: uppercase } #home #content DIV.details DIV.featured-article P.aug { MARGIN: 1em 0px 0px; LINE-HEIGHT: 125%; FONT-STYLE: italic } #home #content DIV.details DIV.goto { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } #home #content DIV.details DIV.goto UL { MARGIN-BOTTOM: 0px } #home #content DIV.details DIV.goto UL LI { PADDING-LEFT: 17px; FONT-WEIGHT: bold; MARGIN-BOTTOM: 0.5em } #home #content DIV.cover-navigation { FLOAT: left; WIDTH: 48% } #home #content DIV.cover-navigation IMG.journal-cover { PADDING-RIGHT: 1px; DISPLAY: block; PADDING-LEFT: 1px; PADDING-BOTTOM: = 1px; PADDING-TOP: 1px } #home #content .wrapper .column1 { FLOAT: left; WIDTH: 48% } #home #content .wrapper .column2 { FLOAT: right; WIDTH: 48% } #home #content DIV.box-item { MARGIN-BOTTOM: 2em } #home #content DIV.box-item H3 { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: = 0px; TEXT-TRANSFORM: uppercase; PADDING-TOP: 5px } #home #content DIV.box-item H4 { PADDING-RIGHT: 5px; PADDING-LEFT: 20px; PADDING-BOTTOM: 5px; MARGIN: = 0px 0px 1em; PADDING-TOP: 5px } #home #content DIV.box-item H4 A:link { TEXT-DECORATION: none } #home #content DIV.box-item H4 A:visited { TEXT-DECORATION: none } #home #content DIV.box-item H4 A:hover { TEXT-DECORATION: none } #home #content DIV.box-item H4 A:focus { TEXT-DECORATION: none } #home #content DIV.box-item IMG.illustration { PADDING-RIGHT: 1px; PADDING-LEFT: 1px; FLOAT: left; PADDING-BOTTOM: = 1px; MARGIN: 0px 5px 5px; PADDING-TOP: 1px } #home #content DIV.box-item H5.atl { MARGIN: 0px 5px 1em 0px } #home #content DIV.box-item H6.atl { MARGIN: 0px 5px 1em 0px } #home #content DIV.research-highlights H5 { MARGIN: 0px 5px 1em } #home #content DIV.research-highlights H6 { MARGIN: 0px 5px 1em } #home #content DIV.box-item P { MARGIN: 0px 5px 1em } #home #content DIV.box-item P.aug { MARGIN-TOP: 0.5em; LINE-HEIGHT: 125%; FONT-STYLE: italic } #home #content DIV.box-item UL { MARGIN: 0px 5px } #home #content DIV.box-item UL LI { PADDING-LEFT: 0px; BACKGROUND-IMAGE: none; MARGIN-BOTTOM: 2em } #home #content DIV.box-item UL LI H5 { MARGIN: 0px } #home #content DIV.box-item UL LI H6 { MARGIN: 0px } #home #content DIV.box-item UL.more-in-field { MARGIN-TOP: 1em } #home #content DIV.box-item UL.more-in-field LI { MARGIN-BOTTOM: 0px; WIDTH: 48% } #home #content DIV.box-item UL.more-in-field LI UL LI { WIDTH: auto } #home #content DIV.box-item UL.more-in-field LI.odd { FLOAT: left } #home #content DIV.box-item UL.more-in-field LI.even { FLOAT: right } #home #content DIV.box-item UL.more-in-field LI H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #home #content DIV.box-item DIV.illustrated H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #home #content DIV.box-item UL.more-in-field LI H4 A:link { TEXT-DECORATION: underline } #home #content DIV.box-item UL.more-in-field LI H4 A:visited { TEXT-DECORATION: underline } #home #content DIV.box-item DIV.illustrated H4 A:link { TEXT-DECORATION: underline } #home #content DIV.box-item DIV.illustrated H4 A:visited { TEXT-DECORATION: underline } #home #content DIV.box-item UL.more-in-field LI P { MARGIN: 0px 0px 1em } #home #content DIV.box-item DIV.illustrated P { MARGIN: 0px 0px 1em } #home #content DIV.box-item DIV.illustrated { MARGIN: 1em 5px } #home #content P.fn { PADDING-LEFT: 10px; BACKGROUND: url(/reviews/images/asterisk.gif) = no-repeat 0px 0.5em; COLOR: #b4b4b4 } #home #content .last-update { MARGIN: 0px; COLOR: #b4b4b4; TEXT-ALIGN: center } #article-related DIV.box H3.article-name { MARGIN: 1em 0px 0px } #article-related DIV.box P.author { FONT-WEIGHT: normal } #article-related DIV.box P.sent-to { FONT-WEIGHT: bold; MARGIN: 0px } #article-related DIV.box P.with { FONT-WEIGHT: bold; MARGIN: 0px } #article #content #articlebody UL.article-views { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 1em; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article #content #articlebody UL.article-views:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #article #content #articlebody UL.article-views { HEIGHT: 1% } #article #content #articlebody UL.article-views LI { PADDING-RIGHT: 0px; PADDING-LEFT: 1em; FONT-WEIGHT: normal; BACKGROUND: = none transparent scroll repeat 0% 0%; FLOAT: left; PADDING-BOTTOM: 0px; = MARGIN: 0px 0px 0px 1em; LINE-HEIGHT: 100%; PADDING-TOP: 0px } #article #content #articlebody UL.article-views LI.first { BORDER-TOP-WIDTH: 0px; PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN-LEFT: 0px; BORDER-RIGHT-WIDTH: 0px } #home #content DIV.web-focus IMG.web-focus { DISPLAY: block; FONT-SIZE: 110%; MARGIN: 0px 0px 1em } #home #content DIV.web-focus H4 { MARGIN-BOTTOM: 0px } #toc #content DIV.section DIV.type H4 SPAN.focus { PADDING-RIGHT: 45px; MIN-HEIGHT: 13px; BACKGROUND: = url(/reviews/images/graphics/icon.focus-article.gif) no-repeat right = center } * HTML #article-related TABLE.data TBODY TD SUP { FONT-SIZE: 120%! important } * HTML #article-related TABLE.data TBODY TD SUB { FONT-SIZE: 120%! important } * HTML #article-related TABLE.data TBODY TD super { FONT-SIZE: 120%! important } #content H1.topten { PADDING-LEFT: 10px; BACKGROUND: #fff } #content P.topten { PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: #fff; MARGIN: 0px 0px = 1em; LINE-HEIGHT: 190% } #content H2.topten { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 7px; PADDING-LEFT: 7px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: #e7e7e7; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; BORDER-RIGHT-WIDTH: 0px } #content .topten.backtotop { PADDING-RIGHT: 17px; BACKGROUND-POSITION: 99% center; DISPLAY: block; = PADDING-LEFT: 17px; FLOAT: none; PADDING-BOTTOM: 3px; MARGIN: 0px; = PADDING-TOP: 3px; BACKGROUND-COLOR: #e7e7e7; TEXT-ALIGN: right } * HTML #content OL.topten { TEXT-ALIGN: left } #content OL.topten { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none } #content OL.topten LI.topten_1 { BACKGROUND: url(/common/images/topten/01.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_2 { BACKGROUND: url(/common/images/topten/02.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_3 { BACKGROUND: url(/common/images/topten/03.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_4 { BACKGROUND: url(/common/images/topten/04.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_5 { BACKGROUND: url(/common/images/topten/05.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_6 { BACKGROUND: url(/common/images/topten/06.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_7 { BACKGROUND: url(/common/images/topten/07.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_8 { BACKGROUND: url(/common/images/topten/08.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_9 { BACKGROUND: url(/common/images/topten/09.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_10 { BACKGROUND: url(/common/images/topten/10.gif) no-repeat 98.5% 10px } #content OL.topten { PADDING-RIGHT: 0px; BORDER-TOP: #e7e7e7 1px solid; PADDING-LEFT: 0px; = BACKGROUND: #ffffff; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = LIST-STYLE-TYPE: none } #content OL.topten .spacing { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; PADDING-BOTTOM: 7px; MARGIN: = 0px; PADDING-TOP: 7px; BORDER-BOTTOM: #e7e7e7 1px solid } #content OL.topten .subject { BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px 0px 5px } #content OL.topten { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; MARGIN: = 1em 0px; PADDING-TOP: 0px } #content OL.topten H2 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-SIZE: 110%; PADDING-BOTTOM: = 5px; MARGIN: 0px 0px 1em; PADDING-TOP: 5px } #content OL.topten H3 { FONT-SIZE: 110%; MARGIN: 0px 0px 0.5em } #content OL.topten H4 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content OL.topten H5 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content OL.topten H6 { FONT-SIZE: 110%; MARGIN: 1em 0px 0px } #content OL.topten UL LI H2 { FONT-SIZE: 100% } #content OL.topten UL LI H3 { FONT-SIZE: 100% } #content OL.topten UL LI H4 { FONT-SIZE: 100% } #content OL.topten UL LI H5 { FONT-SIZE: 100% } #content OL.topten UL LI H6 { FONT-SIZE: 100% } #content OL.topten H3.emphasize { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 5px; MARGIN: 0px = 0px 1em; PADDING-TOP: 5px } #content OL.topten H3 .label { DISPLAY: block } #content OL.topten P { FONT-SIZE: 110%; MARGIN: 0px 0px 1em; LINE-HEIGHT: 190% } #content OL.topten UL LI P { FONT-SIZE: 100% } #article #extranav #articlenav UL LI.commercial_reprints { BACKGROUND: url(/reviews/images/icons/ocr.gif) no-repeat 5px 0px } DIV.reg-rec UL LI.ja A { BACKGROUND: url(/common/images/icons/fff/japanese.gif) no-repeat 0px = 0.1em } DIV.reg-rec UL LI.en A { BACKGROUND: url(/common/images/icons/all/english.gif) no-repeat 0px 0px } #article #extranav #articlenav UL LI.sermo { MARGIN-TOP: 0px; PADDING-LEFT: 0px; BACKGROUND-IMAGE: none; = MARGIN-LEFT: 0px; PADDING-TOP: 0px } #articlenav LI.sermo IMG { MARGIN-LEFT: 5px; VERTICAL-ALIGN: middle } #articlenav LI.sermo FORM { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; PADDING-TOP: 0px! important } #article #extranav #articlenav UL LI.sermo A { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 0px 6px; PADDING-TOP: 0px } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nrc/style/site.css #hdr .user-services .li1 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_account_grey.gif) } #hdr .user-services .li2 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_ealert_grey.gif) } #hdr .user-services .li3 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_register_grey.gif) } #hdr .user-services .li4 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_subscribe_grey.gif) } #head-er .image-user-services-wrap { BACKGROUND-COLOR: #007c88 } #head-er .image-user-services IMG.journal-header { MARGIN: 0px; WIDTH: 276px; HEIGHT: 74px } #head-er .image-user-services { =09 } #head-er .user-services A:link { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .user-services A:visited { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #666 no-repeat = right center } #head-er .user-services A:focus { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #666 no-repeat = right center } A:link { COLOR: #007d7b } A:visited { COLOR: #007d7b } A:hover { COLOR: #c03 } A:focus { COLOR: #c03 } #breadcrumb DIV A:link { COLOR: #007d7b } #breadcrumb DIV A:visited { COLOR: #007d7b } #content { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 1px solid } MAP.journal-nav UL { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid } MAP.journal-nav UL LI { BORDER-BOTTOM: #fff 1px solid } MAP.journal-nav UL LI.menu-heading { BACKGROUND: #fff } MAP.journal-nav UL LI A:link { COLOR: #000; BACKGROUND-COLOR: #c8d9db } MAP.journal-nav UL LI A:visited { COLOR: #000; BACKGROUND-COLOR: #c8d9db } MAP.journal-nav UL LI A:hover { COLOR: #fff; BACKGROUND-COLOR: #007d8c } MAP.journal-nav UL LI A:focus { COLOR: #fff; BACKGROUND-COLOR: #007d8c } MAP.journal-nav UL LI.selected A:link { COLOR: #fff; BACKGROUND-COLOR: #007d8c } MAP.journal-nav UL LI.selected A:visited { COLOR: #fff; BACKGROUND-COLOR: #007d8c } MAP.supplementary.journal-nav UL LI A.onsub:link { BACKGROUND: url(/common/images/online_submissions.gif) #e0e9e9 = no-repeat left center } MAP.supplementary.journal-nav UL LI A.onsub:visited { BACKGROUND: url(/common/images/online_submissions.gif) #e0e9e9 = no-repeat left center } MAP.supplementary.journal-nav UL LI A.onsub:hover { BACKGROUND-COLOR: #007d8c } MAP.supplementary.journal-nav UL LI A.onsub:focus { BACKGROUND-COLOR: #007d8c } MAP.supplementary.journal-nav UL LI A.e-alerts:link { PADDING-LEFT: 23px; BACKGROUND: url(/reviews/images/icons/signup.gif) = #c8d9db no-repeat 5px 7px } MAP.supplementary.journal-nav UL LI A.e-alerts:visited { PADDING-LEFT: 23px; BACKGROUND: url(/reviews/images/icons/signup.gif) = #c8d9db no-repeat 5px 7px } MAP.supplementary.journal-nav UL LI A.e-alerts:hover { PADDING-LEFT: 23px; BACKGROUND: url(/reviews/images/icons/signup.gif) = #007d8c no-repeat 5px 7px } MAP.journal-nav UL LI UL.subnav LI { BORDER-TOP: #fff 1px solid } MAP.journal-nav UL LI UL.subnav A:link { BACKGROUND: url(/nrc/images/graphics/bg.subnav.gif) #efefef no-repeat = 11px 5px } MAP.journal-nav UL LI UL.subnav A:visited { BACKGROUND: url(/nrc/images/graphics/bg.subnav.gif) #efefef no-repeat = 11px 5px } MAP.journal-nav UL LI UL.subnav A:hover { BACKGROUND: url(/nrc/images/graphics/bg.subnav.gif) #d0d0d7 no-repeat = 11px 5px; COLOR: #000 } MAP.journal-nav UL LI UL.subnav A:focus { BACKGROUND: url(/nrc/images/graphics/bg.subnav.gif) #d0d0d7 no-repeat = 11px 5px; COLOR: #000 } MAP.journal-nav UL LI UL.subnav LI.selected A:link { BACKGROUND: url(/nrc/images/graphics/bg.subnav.gif) #d0d0d7 no-repeat = 11px 5px; COLOR: #000 } MAP.journal-nav UL LI UL.subnav LI.selected A:visited { BACKGROUND: url(/nrc/images/graphics/bg.subnav.gif) #d0d0d7 no-repeat = 11px 5px; COLOR: #000 } DIV.reg-rec { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid } DIV.reg-rec UL { BACKGROUND: #e0e9e9 } DIV.reg-rec UL LI A:link { COLOR: #000 } DIV.reg-rec UL LI A:visited { COLOR: #000 } DIV.reg-rec UL LI A:hover { COLOR: #000 } DIV.reg-rec UL LI A:focus { COLOR: #000 } .box#natjob { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid } .box#natjob H2.natjob { BACKGROUND: #d8d8d8 } .box#natjob UL.natjob LI H3 A:link { COLOR: #007d7b } .box#natjob UL.natjob LI H3 A:visited { COLOR: #007d7b } .box#natjob UL.natjob LI H3 A:hover { COLOR: #c03 } .box#natjob UL.natjob LI H3 A:focus { COLOR: #c03 } .box#natjob DIV.natjobmore { BORDER-TOP: #cecfce 1px solid } .box#natjob DIV.natjobmore A:link { BACKGROUND: url(/common/images/icons/next.gif) no-repeat left center; = COLOR: #007d7b } .box#natjob DIV.natjobmore A:visited { BACKGROUND: url(/common/images/icons/next.gif) no-repeat left center; = COLOR: #007d7b } .box#natjob DIV.natjobmore A:hover { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); COLOR: #c03 } .box#natjob DIV.natjobmore A:focus { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); COLOR: #c03 } .box#natprod { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid } .box#natprod H2.natprod { BACKGROUND: #d8d8d8 } DIV.ad-rh { BACKGROUND: #fff } DIV.ad-rh P { COLOR: #cccccb } .page-heading H1 { COLOR: #000; PADDING-TOP: 0px } .page-heading H1.series { BACKGROUND: url(/nrc/images/graphics/bg.icon.series.jpg) no-repeat left = center } #content DIV.box H2 { PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: 130%; PADDING-BOTTOM: = 0px; TEXT-TRANSFORM: uppercase; COLOR: #bd153b; PADDING-TOP: 10px; = BORDER-BOTTOM: #e3e3e3 1px solid } #content DIV.box H3 { COLOR: #000 } #content DIV.box H3.emphasize { FONT-WEIGHT: bold; FONT-SIZE: 130%; PADDING-BOTTOM: 0px; = TEXT-TRANSFORM: uppercase; COLOR: #bd153b; PADDING-TOP: 10px; = BORDER-BOTTOM: #e3e3e3 1px solid } #content DIV.box H3 .label { COLOR: #8a8c9f } #content DIV.box A.pdf:link { BORDER-RIGHT: #c1bfc1 1px solid; BORDER-TOP: #c1bfc1 1px solid; = BORDER-LEFT: #c1bfc1 1px solid; COLOR: #000; BORDER-BOTTOM: #c1bfc1 1px = solid } #content DIV.box A.pdf:visited { BORDER-RIGHT: #c1bfc1 1px solid; BORDER-TOP: #c1bfc1 1px solid; = BORDER-LEFT: #c1bfc1 1px solid; COLOR: #000; BORDER-BOTTOM: #c1bfc1 1px = solid } #content DIV.box A.rss:link { BORDER-RIGHT: #c1bfc1 1px solid; BORDER-TOP: #c1bfc1 1px solid; = BORDER-LEFT: #c1bfc1 1px solid; COLOR: #000; BORDER-BOTTOM: #c1bfc1 1px = solid } #content DIV.box A.visited.rss { BORDER-RIGHT: #c1bfc1 1px solid; BORDER-TOP: #c1bfc1 1px solid; = BORDER-LEFT: #c1bfc1 1px solid; COLOR: #000; BORDER-BOTTOM: #c1bfc1 1px = solid } #content DIV.box UL LI { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.gif) no-repeat = 0px 0.5em } #content DIV.box UL.page-link-list LI { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-down.gif) no-repeat = 0px 0.6em } #content DIV.box UL.page-nolink-list LI { BACKGROUND: url(/nrc/images/graphics/bullet_no_link.gif) no-repeat 0px = 0.4em } #content DIV.box UL.anchor-list LI { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-down.gif) #e0e9e9 = no-repeat 10px 50% } #content DIV.box OL.conference-list H3 { FONT-WEIGHT: bold; FONT-SIZE: 130%; PADDING-BOTTOM: 0px; = TEXT-TRANSFORM: uppercase; COLOR: #bd153b; PADDING-TOP: 20px; = BORDER-BOTTOM: #e3e3e3 1px solid } #content DIV.box DL.faq-list DT { BACKGROUND: url(/nrc/images/graphics/icon.faq.question.gif) no-repeat = left top } #content DIV.box DL.faq-list DD { BACKGROUND: url(/nrc/images/graphics/icon.faq.answer.gif) no-repeat = left top } #content DIV.box H3.address-type-heading { COLOR: #8a8c9f } #content DIV.box H4.address-type-heading { COLOR: #8a8c9f } #content DIV.box H5.address-type-heading { COLOR: #8a8c9f } #content DIV.box H6.address-type-heading { COLOR: #8a8c9f } TABLE.data { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #d0d0d0 1px solid } TABLE.data CAPTION { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = FONT-WEIGHT: bold; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: = #d0d0d0 1px solid } TABLE.data THEAD TR { BACKGROUND: #e7e6ec } TABLE.data TBODY TR.even { BACKGROUND: #f5f5f5 } TABLE.data TFOOT TR { BORDER-TOP: #d0d0d0 1px solid } #article #content DIV.box #cite { COLOR: #7c7c7c } #article #content DIV.box #aug { COLOR: #8a8a8a } #article #content DIV.box H3 { BACKGROUND: #fff } #article #content DIV.box H4 { BACKGROUND: #fff } #article #content DIV.box DIV.figure-table { BORDER-RIGHT: #e0e0e0 1px solid; BORDER-TOP: #e0e0e0 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e0e0e0 1px solid; BORDER-BOTTOM: = #e0e0e0 1px solid } #article #content DIV.box DIV.figure-table UL.options LI.full { BACKGROUND: url(/reviews/images/icons/full_figure.gif) no-repeat left = center } #article #content DIV.box DIV.figure-table UL.options LI.fti { BACKGROUND: url(/reviews/images/icons/full_figure.gif) no-repeat left = center } #article #content DIV.box DIV.figure-table UL.options LI.high-res { BACKGROUND: url(/reviews/images/icons/highres.gif) no-repeat left = center } #article #content DIV.box DIV.figure-table UL.options LI.powerpoint { BACKGROUND: url(/reviews/images/icons/ppt.gif) no-repeat left top } #article #content DIV.box DIV.figure-table UL.options LI.chemdraw { BACKGROUND: url(/nrc/images/graphics/icon.16x16.chemdraw.gif) no-repeat = left top } #article #extranav #articlenav { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid } #article #extranav #articlenav H2 { BACKGROUND: #cedbde; COLOR: #000 } #article #extranav #articlenav UL.view-tools { BORDER-TOP: #d8d8d8 1px solid } #article #extranav #articlenav UL LI { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-down.gif) no-repeat = 5px 50% } #article #extranav #articlenav UL.view-tools LI { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.gif) no-repeat = 5px 0.6em } #article #extranav #articlenav UL LI.download-pdf { BACKGROUND: url(/reviews/images/icons/pdf.gif) no-repeat 5px 0px } #article #extranav #articlenav UL LI.sendtofriend { BACKGROUND: url(/reviews/images/icons/send.gif) no-repeat 5px 0.5em } #article #extranav #articlenav UL LI.export { BACKGROUND: url(/reviews/images/icons/export.gif) no-repeat 5px 0px } #article #extranav #articlenav UL LI.permissions { BACKGROUND: url(/reviews/images/icons/reprints.gif) no-repeat 5px 0px } #article #extranav #articlenav UL LI.commercial_reprints { BACKGROUND: url(/reviews/images/icons/ocr.gif) no-repeat 5px 0px } #article #extranav #articlenav UL LI.save { BACKGROUND: url(/reviews/images/icons/savelink.gif) no-repeat 5px 0px } #article #extranav #articlenav UL LI.toc { BACKGROUND: url(/reviews/images/icons/toc.gif) no-repeat 5px 50% } #article #extranav #articlenav UL LI.prev { BACKGROUND: url(/common/images/icons/back.gif) no-repeat 5px 50% } #article #extranav #articlenav UL LI.next { BACKGROUND: url(/common/images/icons/next.gif) no-repeat 5px 50% } #article #extranav #search-pubmed { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid } #article #extranav #search-pubmed H2 { BACKGROUND: #d8d8d8; COLOR: #000 } #article #extranav #search-pubmed LI { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.gif) no-repeat = 5px 0.5em } #article #extranav #search-pubmed LI.more { BORDER-TOP: #cecfce 1px solid } #article #extranav #search-pubmed LI.more A:link { BACKGROUND: url(/common/images/icons/next.gif) no-repeat left center; = COLOR: #684a94 } #article #extranav #search-pubmed LI.more A:visited { BACKGROUND: url(/common/images/icons/next.gif) no-repeat left center; = COLOR: #684a94 } #article #extranav #search-pubmed LI.more A:hover { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); COLOR: #c03 } #article #extranav #search-pubmed LI.more A:focus { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); COLOR: #c03 } #article #content DIV.poster.box IMG.poster-graphic { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BORDER-LEFT: = #ccc 1px solid; BORDER-BOTTOM: #ccc 1px solid } #article-related DIV.box .container-cite H2.note { COLOR: #8a8a8a } #article-related DIV.box .container-cite P.journal { COLOR: #7c7c7c } #article-related DIV.box .container-cite P.doi { COLOR: #7c7c7c } #article-related DIV.box .container-image { BORDER-RIGHT: #e0e0e0 1px solid; BORDER-TOP: #e0e0e0 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e0e0e0 1px solid; BORDER-BOTTOM: = #e0e0e0 1px solid } #article-related DIV.box .container-image-text { BORDER-RIGHT: #e0e0e0 1px solid; BORDER-TOP: #e0e0e0 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e0e0e0 1px solid; BORDER-BOTTOM: = #e0e0e0 1px solid } #article-related DIV.ar-navigation UL LI.back { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-left.gif) no-repeat = left center } #article-related DIV.ar-navigation UL LI.next { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.gif) no-repeat = right center } #article-related DIV.ar-navigation UL LI.down { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-down.gif) no-repeat = left center } #article-related DIV.container-figtab { BORDER-RIGHT: #e0e0e0 1px solid; BACKGROUND: #f5f5f5; BORDER-LEFT: = #e0e0e0 1px solid } #article-related DIV.first.container-figtab { BORDER-TOP: #e0e0e0 1px solid } #article-related DIV.last.container-figtab { BORDER-BOTTOM: #e0e0e0 1px solid } #article-related DIV.container-figtab DIV.container-image A IMG { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BORDER-LEFT: = #ccc 1px solid; BORDER-BOTTOM: #ccc 1px solid } #article-related DIV.container-figtab UL.options LI.full { BACKGROUND: url(/reviews/images/icons/full_figure.gif) no-repeat left = top } #article-related DIV.container-image-text UL.options LI.full { BACKGROUND: url(/reviews/images/icons/full_figure.gif) no-repeat left = top } #article-related DIV.container-figtab UL.options LI.powerpoint { BACKGROUND: url(/reviews/images/icons/ppt.gif) no-repeat left top } #article-related DIV.container-image-text UL.options LI.powerpoint { BACKGROUND: url(/reviews/images/icons/ppt.gif) no-repeat left top } #article-related DIV.container-figtab UL.options LI.chemdraw { BACKGROUND: url(/nrc/images/graphics/icon.16x16.chemdraw.gif) no-repeat = left top } #article-related DIV.container-image-text UL.options LI.chemdraw { BACKGROUND: url(/nrc/images/graphics/icon.16x16.chemdraw.gif) no-repeat = left top } #article-related DIV.box .container-table { BORDER-RIGHT: #e0e0e0 1px solid; BORDER-TOP: #e0e0e0 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e0e0e0 1px solid; BORDER-BOTTOM: = #e0e0e0 1px solid } #article-related DIV.box .container-image-box { BORDER-RIGHT: #e0e0e0 1px solid; BORDER-TOP: #e0e0e0 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e0e0e0 1px solid; BORDER-BOTTOM: = #e0e0e0 1px solid } #article-related TABLE.data { BORDER-TOP: #e0e0e0 1px solid; BORDER-LEFT: #d0d0d0 1px solid } #article-related TABLE.data THEAD TH { BORDER-RIGHT: #fff 1px solid; BACKGROUND: #cedbde; BORDER-BOTTOM: = #d0d0d0 1px solid } #article-related TABLE.data THEAD TH.last { BORDER-BOTTOM-COLOR: #e7e7e7; BORDER-RIGHT-COLOR: #e7e7e7 } #article-related TABLE.data TFOOT TD { BORDER-RIGHT: #fff 1px solid; BACKGROUND: #fff; BORDER-BOTTOM: #e7e7e7 = 1px solid } #article-related TABLE.data TFOOT TD.last { BORDER-RIGHT-COLOR: #e7e7e7 } #article-related TABLE.data TBODY TR { BACKGROUND: #f5f5f5 } #article-related TABLE.data TBODY TR.odd { BACKGROUND: #f5f5f5 } #article-related TABLE.data TBODY TH { BORDER-RIGHT: #fff 1px solid; BACKGROUND: #fff; BORDER-BOTTOM: #e7e7e7 = 1px solid } #article-related TABLE.data TBODY TH.last { BORDER-RIGHT-COLOR: #e7e7e7 } #article-related TABLE.data TBODY TD { BORDER-RIGHT: #fff 1px solid; BORDER-BOTTOM: #e7e7e7 1px solid } #article-related TABLE.data TBODY TD.last { BORDER-BOTTOM-COLOR: #e7e7e7; BORDER-RIGHT-COLOR: #e7e7e7 } #article-related DIV.box DIV.container-sendfriend { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px solid } #article-related DIV.box DIV.container-sendfriend P.essential { COLOR: #999 } #article-related DIV.box DIV.container-sendfriend INPUT.friend { BORDER-RIGHT: #8caeb5 1px solid; BORDER-TOP: #fff 1px solid; = BACKGROUND: #cedbde; BORDER-LEFT: #fff 1px solid; BORDER-BOTTOM: #8caeb5 = 1px solid } #article-related DIV.container-supplementary { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px solid } #article-related #browser-plugins { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px solid } #article-related #browser-plugins H2 { BACKGROUND: none transparent scroll repeat 0% 0%; MARGIN-BOTTOM: 10px; = PADDING-BOTTOM: 3px; COLOR: black; PADDING-TOP: 3px; = BORDER-BOTTOM-STYLE: none } #toc #content DIV.issue DIV.details H2 { BORDER-BOTTOM: #e3e3e3 1px solid } #toc #content DIV.issue DIV.cover-navigation P.previous-issue { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-left.gif) #e9ddd6 = no-repeat 3px 50% } #toc #content DIV.issue DIV.cover-navigation IMG.journal-cover { BORDER-RIGHT: #cfd0cf 1px solid; BORDER-TOP: #cfd0cf 1px solid; = BORDER-LEFT: #cfd0cf 1px solid; BORDER-BOTTOM: #cfd0cf 1px solid } #toc #content DIV.issue DIV.cover-navigation P.about-cover { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.image.gif) = no-repeat left center } #toc #content DIV.section H3 { PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: 130%; PADDING-BOTTOM: = 0px; TEXT-TRANSFORM: uppercase; COLOR: #000; PADDING-TOP: 10px; = BORDER-BOTTOM: #e3e3e3 1px solid } #toc #content DIV.section P.date { COLOR: #8a8c9f } #toc #content DIV.section P.page { COLOR: #8a8c9f } #toc #content DIV.section P.doi { COLOR: #8a8c9f } #toc #content DIV.section UL.article-views LI { BORDER-LEFT: #000 1px solid } #toc #content DIV.section UL.article-views LI.first { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.image.gif) = no-repeat left center } #toc #content DIV.section P.see-also { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.image.gif) = no-repeat left center } #toc #content DIV.section DIV.type H4 { COLOR: #999 } #toc #content DIV.focus DIV.section DIV.type H5 { COLOR: #999 } #toc #content DIV.section DIV.series DIV.type H5 { COLOR: #999 } #toc #content DIV.section DIV.topic H4 SPAN.label { BACKGROUND-COLOR: #fff } #toc #content DIV.section DIV.topic H4 SPAN.focus { BACKGROUND: url(/nrc/images/graphics/icon.focus-article.gif) no-repeat = right center } #toc #content DIV.focus H3 { BACKGROUND: #007d8c; COLOR: #fff; BORDER-BOTTOM: #fff 1px solid } #toc #content DIV.focus H3 A:link { COLOR: #fff } #toc #content DIV.focus H3 A:visited { COLOR: #fff } #toc #content DIV.focus H3 A:hover { COLOR: #e7e6ec } #toc #content DIV.focus H3 A:focus { COLOR: #e7e6ec } #toc #content DIV.focus H3 SPAN.focus { BACKGROUND: url(/nrc/images/graphics/icon.focus.gif) no-repeat left = center } #toc #content DIV.focus DIV.section { BORDER-RIGHT: #d8d8d8 1px solid; BORDER-TOP: #d8d8d8 0px solid; = BORDER-LEFT: #d8d8d8 1px solid; BORDER-BOTTOM: #d8d8d8 1px solid } #toc #content DIV.focus DIV.section H4 { BORDER-BOTTOM: #d8d8d8 1px solid; BACKGROUND-COLOR: #e0e9e9 } #toc #content DIV.section DIV.series H4 { COLOR: #f00 } #toc #content DIV.focus DIV.section DIV.series H5 { COLOR: #f00 } #toc #content DIV.section DIV.series H4 SPAN.series { BACKGROUND: url(/nrc/images/graphics/icon.series-article.gif) no-repeat = left center } #toc #content DIV.focus DIV.section DIV.series H5 SPAN.series { BACKGROUND: url(/nrc/images/graphics/icon.series-article.gif) no-repeat = left center } #toc #content DIV.orphan.section DIV.type { BORDER-RIGHT: #d8d8d8 1px solid; BORDER-TOP: #d8d8d8 1px solid; = BORDER-LEFT: #d8d8d8 1px solid; BORDER-BOTTOM: #d8d8d8 1px solid } #toc #content DIV.archive-calendar { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px } #toc #content DIV.archive-calendar H2 { PADDING-LEFT: 10px; COLOR: #000; BORDER-BOTTOM-STYLE: none } #toc #content DIV.archive-calendar UL LI A:link { COLOR: #000 } #toc #content DIV.archive-calendar UL LI A:visited { COLOR: #000 } #toc #content DIV.archive-calendar UL UL LI { BORDER-LEFT: #000 1px solid } #toc #content DIV.archive-calendar UL UL LI A:link { COLOR: #007d8c } #toc #content DIV.archive-calendar UL UL LI A:visited { COLOR: #007d8c } #toc #content DIV.archive-calendar UL UL LI A:hover { COLOR: #c03 } #toc #content DIV.archive-calendar UL UL LI A:focus { COLOR: #c03 } #toc #content #archiveMonths DIV.spacing { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 0px solid; = BACKGROUND: #f5f5f5; MARGIN-BOTTOM: 2em; PADDING-BOTTOM: 0px; = BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 1px solid } #toc #content #archiveMonths UL LI { BORDER-LEFT: #000 1px solid } #toc #content #archiveMonths UL LI.current-view { COLOR: #999 } #toc #content #archiveMonths UL LI A:link { COLOR: #007d8c } #toc #content #archiveMonths UL LI A:visited { COLOR: #007d8c } #toc #content #archiveMonths UL LI A:hover { COLOR: #c03 } #toc #content #archiveMonths UL LI A:focus { COLOR: #c03 } #toc #content #archiveArticles { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 1px solid } #toc #content #archiveArticles H3 { BACKGROUND: #007d8c; COLOR: #fff } #toc #content #archiveArticles DIV.spacing P.doi { COLOR: #8a8c9f } #toc #content #archiveArticles DIV.spacing UL.article-views LI { BORDER-LEFT: #000 1px solid } #toc #content #archiveArticles DIV.spacing UL.article-views LI.first { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.image.gif) = no-repeat left center } #archive #content DIV.archive-views { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px solid } #archive #content DIV.subject H2 { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px solid } #archive #content DIV.archive-views H2 { MARGIN: 5px 0px; COLOR: #000 } #archive #content DIV.archive-views UL LI { BORDER-LEFT: #000 1px solid } #archive #content DIV.archive-views UL LI.current-view { COLOR: #999 } #archive #content DIV.archive-views UL LI A:link { COLOR: #007d8c } #archive #content DIV.archive-views UL LI A:visited { COLOR: #007d8c } #archive #content DIV.archive-views UL LI A:hover { COLOR: #c03 } #archive #content DIV.archive-views UL LI A:focus { COLOR: #c03 } #archive #content UL.vol DIV { BORDER-RIGHT: #d7dde3 1px solid; BORDER-TOP: #d7dde3 1px solid; = BACKGROUND: #f2f4f7; BORDER-LEFT: #d7dde3 1px solid; BORDER-BOTTOM: = #d7dde3 1px solid } #archive #content UL.vol .month { BACKGROUND: #e7ebef; BORDER-BOTTOM: #d7dde3 1px solid } #archive #content UL.vol .issue { BORDER-BOTTOM: #d7dde3 1px solid } #archive #content UL.vol .issue:hover { BACKGROUND-COLOR: #fff } #archive #content UL.vol .not-published .issue:hover { BACKGROUND-COLOR: #fafafa } #archive #content DIV.box UL.vol .issue-no { BORDER-BOTTOM: #d7dde3 1px solid } #archive #content UL.vol .supname { BORDER-BOTTOM: #d7dde3 1px solid } #archive #content UL.vol .not-published DIV { BACKGROUND: #fafafa; COLOR: #888 } #archive #content UL.vol .not-published .month { BACKGROUND: #eee } #archive #web-focuses H2.year { BACKGROUND-COLOR: #fff } #archive #web-focuses DIV.supp IMG { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BORDER-LEFT: = #ccc 1px solid; BORDER-BOTTOM: #ccc 1px solid } #archive #web-focuses DIV.supp H4.atl SPAN.updated { COLOR: #f00 } #archive #web-focuses DIV.supp P.date { COLOR: #999 } #archive #web-focuses DIV.supp P.support { COLOR: #999 } #archive #posters DIV.odd.supp { BACKGROUND: #f5f5f5 } #archive #posters DIV.supp H2 { TEXT-TRANSFORM: none; BORDER-BOTTOM-STYLE: none } #archive #posters DIV.supp IMG { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BORDER-LEFT: = #ccc 1px solid; BORDER-BOTTOM: #ccc 1px solid } #archive #posters DIV.supp P.description { COLOR: #999 } #archive #posters DIV.supp P.date { COLOR: #999 } #subscribe-now #content DIV.container { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 1px solid; = BACKGROUND-COLOR: #f5f5f5 } #subscribe-now #content .button { BORDER-RIGHT: #8caeb5 1px solid; BORDER-TOP: #fff 1px solid; = BACKGROUND: #cedbde; BORDER-LEFT: #fff 1px solid; COLOR: #000; = BORDER-BOTTOM: #8caeb5 1px solid } #subscribe-now #content DIV.container A.register { BORDER-RIGHT: #8caeb5 1px solid; BORDER-TOP: #fff 1px solid; = BACKGROUND: #cedbde; BORDER-LEFT: #fff 1px solid; COLOR: #000; = BORDER-BOTTOM: #8caeb5 1px solid } #toc #content DIV.article P.correspondence { COLOR: #8a8c9f } DIV.reg-rec UL.toc-pdf { BACKGROUND: #fff } DIV.reg-rec UL.toc-pdf A:link { BACKGROUND: url(/reviews/images/printer.gif) no-repeat 0px 3px } DIV.reg-rec UL.toc-pdf A:visited { BACKGROUND: url(/reviews/images/printer.gif) no-repeat 0px 3px } #toc #content DIV.cover-navigation UL.prev-next { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #toc #content DIV.cover-navigation UL.prev-next LI { BACKGROUND-IMAGE: none } #toc #content DIV.cover-navigation UL.prev-next LI A:link { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-left.gif) no-repeat = left center } #toc #content DIV.cover-navigation UL.prev-next LI A:visited { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-left.gif) no-repeat = left center } #toc #content DIV.cover-navigation UL.prev-next LI.next A:link { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.gif) no-repeat = right center } #toc #content DIV.cover-navigation UL.prev-next LI.next A:visited { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.gif) no-repeat = right center } #toc #content #archiveMonths H2 { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 5px; BACKGROUND: #f5f5f5; = MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 0px; BORDER-LEFT: #e7e7e7 1px solid; = COLOR: #000; PADDING-TOP: 5px; BORDER-BOTTOM: #e7e7e7 1px solid } #about-cover #content DIV.coverimage { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 1px solid; = BACKGROUND-COLOR: #f5f5f5 } #about-cover #content DIV.coverimage IMG { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BACKGROUND: = #fff; BORDER-LEFT: #ccc 1px solid; BORDER-BOTTOM: #ccc 1px solid } #about-cover #content DIV.covertext { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 1px solid; = BACKGROUND-COLOR: #f5f5f5 } #article #content DIV.box OL.twenty-questions UL LI H6 A:link { BACKGROUND: url(/nrc/images/graphics/icon.arrow.down.gif) no-repeat = left center } #article #content DIV.box OL.twenty-questions UL LI H6 A:visited { BACKGROUND: url(/nrc/images/graphics/icon.arrow.down.gif) no-repeat = left center } #article #content DIV.web-watch UL.web-watch-links { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px solid } #article #content DIV.disease-watch #articlebody DIV.item H3 { BACKGROUND: url(/nrc/images/graphics/bullet_no_link.gif) no-repeat left = center } #article #content DIV.box H2#atl { FONT-WEIGHT: bold; FONT-SIZE: 140%; TEXT-TRANSFORM: none; COLOR: #000 } #article #content DIV.box H2#atl SPAN.label { FONT-WEIGHT: bold; FONT-SIZE: 75%; COLOR: #8a8a8a } #article #content DIV.box P.focus { COLOR: #f00 } #article #content DIV.box P.series { COLOR: #f00 } #article #content DIV.box P.focus { BACKGROUND: url(/nrc/images/graphics/icon.focus.sxtitle.gif) no-repeat = left center } #article #content DIV.box P.series { BACKGROUND: url(/nrc/images/graphics/icon.series-article.gif) no-repeat = left center } #article #content BLOCKQUOTE.box { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BORDER-LEFT: = #ccc 1px solid; BORDER-BOTTOM: #ccc 1px solid } #article #content BLOCKQUOTE.box P.quote-source { BORDER-TOP: #ccc 1px solid } #article #content #links H5 { COLOR: #8a8a8a } #article #content #links UL LI { BORDER-LEFT: #000 1px solid } #article #content #references-links H5 { COLOR: #8a8a8a } #article #content #references-links OL.references LI UL.article-views LI = { BORDER-LEFT: #000 1px solid } #article #content #References OL.references LI UL.article-views LI { BORDER-LEFT: #000 1px solid } #article #content #prev-next UL.prev-next LI.prev A:link { BACKGROUND: url(/common/images/icons/back.gif) no-repeat left center } #article #content #prev-next UL.prev-next LI.prev A:visited { BACKGROUND: url(/common/images/icons/back.gif) no-repeat left center } #article #content #prev-next UL.prev-next LI.prev A:hover { BACKGROUND-IMAGE: url(/common/images/icons/back_hover.gif) } #article #content #prev-next UL.prev-next LI.prev A:focus { BACKGROUND-IMAGE: url(/common/images/icons/back_hover.gif) } #article #content #prev-next UL.prev-next LI.next A:link { BACKGROUND: url(/common/images/icons/next.gif) no-repeat right center } #article #content #prev-next UL.prev-next LI.next A:visited { BACKGROUND: url(/common/images/icons/next.gif) no-repeat right center } #article #content #prev-next UL.prev-next LI.next A:hover { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif) } #article #content #prev-next UL.prev-next LI.next A:focus { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif) } #home #content DIV.details DIV.featured-article { BORDER-RIGHT: #e7ebef 1px solid; BORDER-TOP: #e7ebef 1px solid; = BORDER-LEFT: #e7ebef 1px solid; BORDER-BOTTOM: #e7ebef 1px solid } #home #content DIV.details DIV.goto { BACKGROUND: #f5f5f5 } #home #content DIV.cover-navigation IMG.journal-cover { BORDER-RIGHT: #cfd0cf 1px solid; BORDER-TOP: #cfd0cf 1px solid; = BORDER-LEFT: #cfd0cf 1px solid; BORDER-BOTTOM: #cfd0cf 1px solid } #home #content DIV.box-item { BORDER-RIGHT: #e7ebef 1px solid; BORDER-TOP: #e7ebef 1px solid; = BORDER-LEFT: #e7ebef 1px solid; BORDER-BOTTOM: #e7ebef 1px solid } #home #content H2 { TEXT-TRANSFORM: none } #home #content DIV.box-item H3 { BACKGROUND: #007d8c; COLOR: #fff } #home #content DIV.box-item H4 { BACKGROUND: url(/nrc/images/graphics/icon.arrow.right.gif) #e0e9e9 = no-repeat 5px 50%; BORDER-BOTTOM: #e7ebef 1px solid } #home #content DIV.box-item H4 A:link { COLOR: #000 } #home #content DIV.box-item H4 A:visited { COLOR: #000 } #home #content DIV.box-item H4 A:hover { COLOR: #000 } #home #content DIV.box-item H4 A:focus { COLOR: #000 } #home #content DIV.box-item IMG.illustration { BORDER-RIGHT: #cfcecf 1px solid; BORDER-TOP: #cfcecf 1px solid; = BORDER-LEFT: #cfcecf 1px solid; BORDER-BOTTOM: #cfcecf 1px solid } #home #content DIV.box-item UL.more-in-field LI H4 A:link { COLOR: #007d8c } #home #content DIV.box-item UL.more-in-field LI H4 A:visited { COLOR: #007d8c } #home #content DIV.box-item DIV.illustrated H4 A:link { COLOR: #007d8c } #home #content DIV.box-item DIV.illustrated H4 A:visited { COLOR: #007d8c } #home #content DIV.box-item UL.more-in-field LI H4 A:hover { COLOR: #c03 } #home #content DIV.box-item UL.more-in-field LI H4 A:focus { COLOR: #c03 } #home #content DIV.box-item DIV.illustrated H4 A:hover { COLOR: #c03 } #home #content DIV.box-item DIV.illustrated H4 A:focus { COLOR: #c03 } #home #content P.fn { COLOR: #b4b4b4 } #article-related DIV.box .container-more { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #f5f5f5; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: = #e7e7e7 1px solid } #article-related DIV.box H2.from { COLOR: #8a8a8a } #article-related DIV.box P.sent-to { COLOR: #8a8a8a } #article-related DIV.box P.with { COLOR: #8a8a8a } #article #content #articlebody UL.article-views LI { BORDER-LEFT: #000 1px solid } #article #extranav #articlenav UL LI.fulltext { BACKGROUND: url(/reviews/images/icons/toc.gif) no-repeat 5px 0.25em } DIV.marketing.ad-rh { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid } DIV.marketing.ad-rh FORM INPUT { BORDER-RIGHT: #000 2px solid; BORDER-TOP: #ccc 2px solid; BACKGROUND: = #8c3670; BORDER-LEFT: #ccc 2px solid; COLOR: #fff; BORDER-BOTTOM: #000 = 2px solid } * HTML DIV.marketing { BACKGROUND: #fff } DIV.marketing.ad-rh H2 { BACKGROUND: #d8d8d8; COLOR: #000 } DIV.marketing.ad-rh P { COLOR: #000 } * HTML DIV.marketing.ad-rh P { COLOR: #000 } DIV.ad-rh { BACKGROUND: #fff } DIV.ad-rh P { COLOR: #cccccb } DIV.marketing.ad-rh { BORDER-RIGHT: #e7e7e7 1px solid; BORDER-TOP: #e7e7e7 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #e7e7e7 1px solid; BORDER-BOTTOM: #e7e7e7 = 1px solid; TEXT-ALIGN: center } DIV.marketing.ad-rh H1 { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-SIZE: 100%; BACKGROUND: = #c8d9db; PADDING-BOTTOM: 3px; MARGIN: 0px 0px 1em; COLOR: #000; = PADDING-TOP: 3px; TEXT-ALIGN: left } #toc #content OL.topten DIV.article UL.article-views LI.first { BACKGROUND-ATTACHMENT: scroll; BACKGROUND-IMAGE: = url(/nrc/images/graphics/bullet.arrow-right.image.gif); = BACKGROUND-REPEAT: no-repeat; BACKGROUND-COLOR: transparent; = background-x-position: left; background-y-position: center } #toc #content OL.topten UL.article-views LI.first { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.image.gif) = no-repeat left center } #toc #content OL.topten UL.article-views { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.5em 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #toc #content OL.topten UL.article-views:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #toc #content OL.topten UL.article-views { HEIGHT: 1% } #toc #content OL.topten UL.article-views LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0.5em; MIN-HEIGHT: 12px; FLOAT: left; = BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 0.5em; = LINE-HEIGHT: 100%; PADDING-TOP: 0px } #toc #content OL.topten UL.article-views LI.first { PADDING-LEFT: 18px; BORDER-LEFT-WIDTH: 0px; MARGIN-LEFT: 0px } #toc #content OL.topten UL.article-views LI.pdf { FONT-WEIGHT: bold } #toc #content DIV.spacing OL.topten UL.article-views LI { BORDER-LEFT: #000 1px solid } #toc #content DIV.spacing OL.topten UL.article-views LI.first { BACKGROUND: url(/nrc/images/graphics/bullet.arrow-right.image.gif) = no-repeat left center } #toc #content OL.topten H5.atl { MARGIN-TOP: 0px; TEXT-TRANSFORM: none; COLOR: #000 } #toc #content OL.topten H4 { COLOR: #999999 } #toc #content OL.topten H5 { COLOR: #999999 } #toc #content OL.topten H5 { COLOR: #999999 } #toc #content OL.topten H4 { FONT-SIZE: 110%; MARGIN: 0pt; TEXT-TRANSFORM: uppercase } #toc #content OL.topten H5 { FONT-SIZE: 110%; MARGIN: 0pt; TEXT-TRANSFORM: uppercase } #toc #content OL.topten H5 { FONT-SIZE: 110%; MARGIN: 0pt; TEXT-TRANSFORM: uppercase } #toc #content OL.topten H4 { MARGIN-TOP: 0.5em } #toc #content OL.topten H5 { MARGIN-TOP: 0.5em } #toc #content OL.topten H6 { MARGIN-TOP: 0.5em } #toc #content OL.topten P.date { COLOR: #8a8c9f } #toc #content OL.topten P.page { COLOR: #8a8c9f } #toc #content DIV.section P.doi { COLOR: #8a8c9f } #toc #content OL.topten P.page { FONT-SIZE: 110%; MARGIN: 0pt 0pt 0.5em; LINE-HEIGHT: 150% } #toc #content DIV.section P.doi { FONT-SIZE: 110%; MARGIN: 0pt 0pt 0.5em; LINE-HEIGHT: 150% } #toc #content OL.topten P.aug { FONT-SIZE: 110%; MARGIN: 0pt; LINE-HEIGHT: 150%; FONT-STYLE: italic } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/restrict_width/966px.css #head-er .accessibility-login { MAX-WIDTH: 966px; MARGIN: 0px auto } #head-er .image-user-services { MAX-WIDTH: 966px; MARGIN: 0px auto } #head-er .publications-search { MAX-WIDTH: 966px; MARGIN: 0px auto } DIV.footer-constrain { MAX-WIDTH: 966px; MARGIN: 0px auto } * HTML #head-er .accessibility-login-wrap { TEXT-ALIGN: center } * HTML #head-er .image-user-services-wrap { TEXT-ALIGN: center } * HTML #head-er .publications-search-wrap { TEXT-ALIGN: center } * HTML DIV.footer-constrain { TEXT-ALIGN: center } #breadcrumb { MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } #constrain { CLEAR: both; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; TEXT-ALIGN: center } .constrain-outer { CLEAR: both; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; TEXT-ALIGN: center } #constrain .constrain { MAX-WIDTH: 966px; MARGIN-LEFT: auto; MARGIN-RIGHT: auto; TEXT-ALIGN: = left } .constrain-outer .constrain { MAX-WIDTH: 966px; MARGIN-LEFT: auto; MARGIN-RIGHT: auto; TEXT-ALIGN: = left } BODY DIV.margin-provider#content { MARGIN: 0px } #content-journalnav { MARGIN-LEFT: 0px } #content-extranav { MARGIN-RIGHT: 0px } #extranav { MARGIN-RIGHT: 0px } #journalnav { MARGIN-LEFT: 0px } #article-related #content { MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/print.css #header { DISPLAY: none } #head-er { DISPLAY: none } #breadcrumb { DISPLAY: none } .no-css { DISPLAY: none } #journalnav { DISPLAY: none } #journal-header { DISPLAY: none } #extranav { DISPLAY: none } #footer { DISPLAY: none } #foot-er { DISPLAY: none } #footer-sponsor { DISPLAY: none } #npglogo { DISPLAY: none } #hdr .publications-search { DISPLAY: none } #hdr .leaderboard-links { DISPLAY: none } #hdr .logon { DISPLAY: none } #hdr .header-nav { DISPLAY: none } #hdr #header-nav { DISPLAY: none } #ftr { DISPLAY: none } #hdr .journal-header IMG { DISPLAY: block! important } #content-journalnav { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: 100%; PADDING-TOP: 0px } #content { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: 100%; PADDING-TOP: 0px } #footer-copyright { CLEAR: both; BORDER-TOP: black 2px solid; MARGIN-TOP: 15px; FONT-SIZE: = 90%; COLOR: #999; PADDING-TOP: 15px } #footer-copyright A { FONT-WEIGHT: normal; COLOR: #000; TEXT-DECORATION: none } #footer-copyright .non-copyright { DISPLAY: none } .print-header { MARGIN-BOTTOM: 15px; PADDING-BOTTOM: 15px; BORDER-BOTTOM: black 2px = solid } BODY { FONT-SIZE: 12pt; BACKGROUND: #fff; COLOR: #000; FONT-FAMILY: georgia, = serif } H1 { FONT-SIZE: 16pt } H2 { FONT-SIZE: 14pt } H3 { FONT-SIZE: 12pt } H4 { FONT-SIZE: 12pt } H5 { FONT-SIZE: 12pt } H6 { FONT-SIZE: 12pt } A:link { FONT-WEIGHT: bold; BACKGROUND: none transparent scroll repeat 0% 0%; = COLOR: #009; TEXT-DECORATION: underline } A:visited { FONT-WEIGHT: bold; BACKGROUND: none transparent scroll repeat 0% 0%; = COLOR: #009; TEXT-DECORATION: underline } #content A:link:unknown { FONT-WEIGHT: normal; content: " (" attr(href) ") " } #content A:visited:unknown { FONT-WEIGHT: normal; content: " (" attr(href) ") " } #article #content DIV BLOCKQUOTE { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #000 = 1px solid; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; MARGIN: 1.26em = 0px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 0.5em; BORDER-BOTTOM: = #000 1px solid; TEXT-ALIGN: center } #article #content DIV BLOCKQUOTE P { MARGIN: 0px } #article #content DIV BLOCKQUOTE IMG { DISPLAY: none } .backtotop { DISPLAY: none } .back-to-article { DISPLAY: none } .prevnext { DISPLAY: none } * HTML #article-related TABLE.data { FONT-SIZE: 7pt; WIDTH: 100% } #article-related TABLE.data { FONT-SIZE: 7pt; WIDTH: 100% } #article-related TABLE.data { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: = #999 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #999 1px solid; = BORDER-COLLAPSE: collapse; TEXT-ALIGN: left } #article-related TABLE.data THEAD { FONT-WEIGHT: bold } #article-related TABLE.data THEAD TH { BORDER-RIGHT: #999 1px solid; BACKGROUND: #f6f6f6; BORDER-LEFT: #999 = 1px solid } #article-related TABLE.data THEAD TH.colspan { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 0px solid; BORDER-LEFT: = #999 1px solid; BORDER-BOTTOM: #999 1px solid; TEXT-ALIGN: center } #article-related TABLE.data THEAD TH.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY { BORDER-TOP: #999 1px solid; BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TR { BACKGROUND-COLOR: #f6f6f6 } #article-related TABLE.data TBODY TR.odd { BACKGROUND-COLOR: #fff } #article-related TABLE.data TBODY TD { BORDER-RIGHT: #999 1px solid; BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TFOOT { POSITION: relative } #article-related TABLE.data TFOOT TD { FONT-SIZE: 7pt; BACKGROUND-COLOR: #fff } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/includes/header/03/style/ie-specific/lte-ie-7.css #hdr .pub1 A { MARGIN-TOP: 7px; DISPLAY: block } #hdr .list-container { FLOAT: left } #hdr .list-container UL { FLOAT: left } #hdr .user-services .us-link A:link { PADDING-BOTTOM: 2px; PADDING-TOP: 0px } #hdr .user-services .us-link A:visited { PADDING-BOTTOM: 2px; PADDING-TOP: 0px } #hdr .list-container UL.list1 { MARGIN-LEFT: 0px; MARGIN-RIGHT: 4px } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/reviews/style/ie-specific/lte-ie-7.css INPUT.sermo-submit:hover { BACKGROUND-COLOR: #fff! important } INPUT.sermo-submit { PADDING-LEFT: 13.5%; BACKGROUND-COLOR: #fff } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/includes/header/03/style/ie-specific/ie-7.css #hdr .list-container UL { WIDTH: 114px } #hdr .list-container UL.list1 { MARGIN-RIGHT: 5px } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/style/ie-specific/ie-7.css BODY { FONT-SIZE: 89% } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/reviews/style/ie-specific/ie-7.css BODY { FONT-SIZE: 62.5% } #article #content #references-links OL.references LI { MARGIN-BOTTOM: 10px } #article #content #References OL.references LI { MARGIN-BOTTOM: 10px } #article #content #references-links OL.references LI P.details { CLEAR: left } #article #content #References OL.references LI P.details { CLEAR: left } #article #content #references-links OL.references LI P.details SUP { LINE-HEIGHT: 0 } #article #content #References OL.references LI P.details SUP { LINE-HEIGHT: 0 } #toc #content DIV.issue DIV.cover-navigation IMG.journal-cover { CLEAR: left; MARGIN-TOP: 10px } #toc #content DIV.section .article { CLEAR: both } ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/scripts/jquery.js /*=0A= * jQuery 1.2.1 - New Wave Javascript=0A= *=0A= * Copyright (c) 2007 John Resig (jquery.com)=0A= * Dual licensed under the MIT (MIT-LICENSE.txt)=0A= * and GPL (GPL-LICENSE.txt) licenses.=0A= *=0A= * $Date: 2007-09-16 23:42:06 -0400 (Sun, 16 Sep 2007) $=0A= * $Rev: 3353 $=0A= */=0A= (function(){if(typeof jQuery!=3D"undefined")var _jQuery=3DjQuery;var = jQuery=3Dwindow.jQuery=3Dfunction(selector,context){return this = instanceof jQuery?this.init(selector,context):new = jQuery(selector,context);};if(typeof $!=3D"undefined")var = _$=3D$;window.$=3DjQuery;var = quickExpr=3D/^[^<]*(<(.|\s)+>)[^>]*$|^#(\w+)$/;jQuery.fn=3DjQuery.prototy= pe=3D{init:function(selector,context){selector=3Dselector||document;if(ty= peof selector=3D=3D"string"){var = m=3DquickExpr.exec(selector);if(m&&(m[1]||!context)){if(m[1])selector=3Dj= Query.clean([m[1]],context);else{var = tmp=3Ddocument.getElementById(m[3]);if(tmp)if(tmp.id!=3Dm[3])return = jQuery().find(selector);else{this[0]=3Dtmp;this.length=3D1;return = this;}else=0A= selector=3D[];}}else=0A= return new jQuery(context).find(selector);}else = if(jQuery.isFunction(selector))return new = jQuery(document)[jQuery.fn.ready?"ready":"load"](selector);return = this.setArray(selector.constructor=3D=3DArray&&selector||(selector.jquery= ||selector.length&&selector!=3Dwindow&&!selector.nodeType&&selector[0]!=3D= undefined&&selector[0].nodeType)&&jQuery.makeArray(selector)||[selector])= ;},jquery:"1.2.1",size:function(){return = this.length;},length:0,get:function(num){return = num=3D=3Dundefined?jQuery.makeArray(this):this[num];},pushStack:function(= a){var ret=3DjQuery(a);ret.prevObject=3Dthis;return = ret;},setArray:function(a){this.length=3D0;Array.prototype.push.apply(thi= s,a);return this;},each:function(fn,args){return = jQuery.each(this,fn,args);},index:function(obj){var = pos=3D-1;this.each(function(i){if(this=3D=3Dobj)pos=3Di;});return = pos;},attr:function(key,value,type){var = obj=3Dkey;if(key.constructor=3D=3DString)if(value=3D=3Dundefined)return = this.length&&jQuery[type||"attr"](this[0],key)||undefined;else{obj=3D{};o= bj[key]=3Dvalue;}return this.each(function(index){for(var prop in = obj)jQuery.attr(type?this.style:this,prop,jQuery.prop(this,obj[prop],type= ,index,prop));});},css:function(key,value){return = this.attr(key,value,"curCSS");},text:function(e){if(typeof = e!=3D"object"&&e!=3Dnull)return = this.empty().append(document.createTextNode(e));var = t=3D"";jQuery.each(e||this,function(){jQuery.each(this.childNodes,functio= n(){if(this.nodeType!=3D8)t+=3Dthis.nodeType!=3D1?this.nodeValue:jQuery.f= n.text([this]);});});return = t;},wrapAll:function(html){if(this[0])jQuery(html,this[0].ownerDocument).= clone().insertBefore(this[0]).map(function(){var = elem=3Dthis;while(elem.firstChild)elem=3Delem.firstChild;return = elem;}).append(this);return this;},wrapInner:function(html){return = this.each(function(){jQuery(this).contents().wrapAll(html);});},wrap:func= tion(html){return = this.each(function(){jQuery(this).wrapAll(html);});},append:function(){re= turn = this.domManip(arguments,true,1,function(a){this.appendChild(a);});},prepe= nd:function(){return = this.domManip(arguments,true,-1,function(a){this.insertBefore(a,this.firs= tChild);});},before:function(){return = this.domManip(arguments,false,1,function(a){this.parentNode.insertBefore(= a,this);});},after:function(){return = this.domManip(arguments,false,-1,function(a){this.parentNode.insertBefore= (a,this.nextSibling);});},end:function(){return = this.prevObject||jQuery([]);},find:function(t){var = data=3DjQuery.map(this,function(a){return jQuery.find(t,a);});return = this.pushStack(/[^+>] = [^+>]/.test(t)||t.indexOf("..")>-1?jQuery.unique(data):data);},clone:func= tion(events){var ret=3Dthis.map(function(){return = this.outerHTML?jQuery(this.outerHTML)[0]:this.cloneNode(true);});var = clone=3Dret.find("*").andSelf().each(function(){if(this[expando]!=3Dundef= ined)this[expando]=3Dnull;});if(events=3D=3D=3Dtrue)this.find("*").andSel= f().each(function(i){var events=3DjQuery.data(this,"events");for(var = type in events)for(var handler in = events[type])jQuery.event.add(clone[i],type,events[type][handler],events[= type][handler].data);});return ret;},filter:function(t){return = this.pushStack(jQuery.isFunction(t)&&jQuery.grep(this,function(el,index){= return = t.apply(el,[index]);})||jQuery.multiFilter(t,this));},not:function(t){ret= urn = this.pushStack(t.constructor=3D=3DString&&jQuery.multiFilter(t,this,true)= ||jQuery.grep(this,function(a){return(t.constructor=3D=3DArray||t.jquery)= ?jQuery.inArray(a,t)<0:a!=3Dt;}));},add:function(t){return = this.pushStack(jQuery.merge(this.get(),t.constructor=3D=3DString?jQuery(t= ).get():t.length!=3Dundefined&&(!t.nodeName||jQuery.nodeName(t,"form"))?t= :[t]));},is:function(expr){return = expr?jQuery.multiFilter(expr,this).length>0:false;},hasClass:function(exp= r){return = this.is("."+expr);},val:function(val){if(val=3D=3Dundefined){if(this.leng= th){var elem=3Dthis[0];if(jQuery.nodeName(elem,"select")){var = index=3Delem.selectedIndex,a=3D[],options=3Delem.options,one=3Delem.type=3D= =3D"select-one";if(index<0)return null;for(var = i=3Done?index:0,max=3Done?index+1:options.length;i=3D0||jQuery.i= nArray(this.name,val)>=3D0);else if(jQuery.nodeName(this,"select")){var = tmp=3Dval.constructor=3D=3DArray?val:[val];jQuery("option",this).each(fun= ction(){this.selected=3D(jQuery.inArray(this.value,tmp)>=3D0||jQuery.inAr= ray(this.text,tmp)>=3D0);});if(!tmp.length)this.selectedIndex=3D-1;}else=0A= this.value=3Dval;});},html:function(val){return = val=3D=3Dundefined?(this.length?this[0].innerHTML:null):this.empty().appe= nd(val);},replaceWith:function(val){return = this.after(val).remove();},eq:function(i){return = this.slice(i,i+1);},slice:function(){return = this.pushStack(Array.prototype.slice.apply(this,arguments));},map:functio= n(fn){return this.pushStack(jQuery.map(this,function(elem,i){return = fn.call(elem,i,elem);}));},andSelf:function(){return = this.add(this.prevObject);},domManip:function(args,table,dir,fn){var = clone=3Dthis.length>1,a;return = this.each(function(){if(!a){a=3DjQuery.clean(args,this.ownerDocument);if(= dir<0)a.reverse();}var = obj=3Dthis;if(table&&jQuery.nodeName(this,"table")&&jQuery.nodeName(a[0],= "tr"))obj=3Dthis.getElementsByTagName("tbody")[0]||this.appendChild(docum= ent.createElement("tbody"));jQuery.each(a,function(){var = elem=3Dclone?this.cloneNode(true):this;if(!evalScript(0,elem))fn.call(obj= ,elem);});});}};function evalScript(i,elem){var = script=3DjQuery.nodeName(elem,"script");if(script){if(elem.src)jQuery.aja= x({url:elem.src,async:false,dataType:"script"});else=0A= jQuery.globalEval(elem.text||elem.textContent||elem.innerHTML||"");if(ele= m.parentNode)elem.parentNode.removeChild(elem);}else = if(elem.nodeType=3D=3D1)jQuery("script",elem).each(evalScript);return = script;}jQuery.extend=3DjQuery.fn.extend=3Dfunction(){var = target=3Darguments[0]||{},a=3D1,al=3Darguments.length,deep=3Dfalse;if(tar= get.constructor=3D=3DBoolean){deep=3Dtarget;target=3Darguments[1]||{};}if= (al=3D=3D1){target=3Dthis;a=3D0;}var = prop;for(;a-1;}},swap:fun= ction(e,o,f){for(var i in = o){e.style["old"+i]=3De.style[i];e.style[i]=3Do[i];}f.apply(e,[]);for(var= i in = o)e.style[i]=3De.style["old"+i];},css:function(e,p){if(p=3D=3D"height"||p= =3D=3D"width"){var = old=3D{},oHeight,oWidth,d=3D["Top","Bottom","Right","Left"];jQuery.each(d= ,function(){old["padding"+this]=3D0;old["border"+this+"Width"]=3D0;});jQu= ery.swap(e,old,function(){if(jQuery(e).is(':visible')){oHeight=3De.offset= Height;oWidth=3De.offsetWidth;}else{e=3DjQuery(e.cloneNode(true)).find(":= radio").removeAttr("checked").end().css({visibility:"hidden",position:"ab= solute",display:"block",right:"0",left:"0"}).appendTo(e.parentNode)[0];va= r = parPos=3DjQuery.css(e.parentNode,"position")||"static";if(parPos=3D=3D"st= atic")e.parentNode.style.position=3D"relative";oHeight=3De.clientHeight;o= Width=3De.clientWidth;if(parPos=3D=3D"static")e.parentNode.style.position= =3D"static";e.parentNode.removeChild(e);}});return = p=3D=3D"height"?oHeight:oWidth;}return = jQuery.curCSS(e,p);},curCSS:function(elem,prop,force){var = ret,stack=3D[],swap=3D[];function = color(a){if(!jQuery.browser.safari)return false;var = ret=3Ddocument.defaultView.getComputedStyle(a,null);return!ret||ret.getPr= opertyValue("color")=3D=3D"";}if(prop=3D=3D"opacity"&&jQuery.browser.msie= ){ret=3DjQuery.attr(elem.style,"opacity");return = ret=3D=3D""?"1":ret;}if(prop.match(/float/i))prop=3DstyleFloat;if(!force&= &elem.style[prop])ret=3Delem.style[prop];else = if(document.defaultView&&document.defaultView.getComputedStyle){if(prop.m= atch(/float/i))prop=3D"float";prop=3Dprop.replace(/([A-Z])/g,"-$1").toLow= erCase();var = cur=3Ddocument.defaultView.getComputedStyle(elem,null);if(cur&&!color(ele= m))ret=3Dcur.getPropertyValue(prop);else{for(var = a=3Delem;a&&color(a);a=3Da.parentNode)stack.unshift(a);for(a=3D0;a]*?)\/>/g,function(m,all,= tag){return = tag.match(/^(abbr|br|col|img|input|link|meta|param|hr|area)$/i)?m:all+"><= /"+tag+">";});var = s=3DjQuery.trim(arg).toLowerCase(),div=3Ddoc.createElement("div"),tb=3D[]= ;var = wrap=3D!s.indexOf("",""]||!s.indexOf("",""]||s.match(/^<(thead|tbody|tfoot|colg|cap)= /)&&[1,"","
"]||!s.indexOf("",""]||(!s.indexOf("",""]||!s.indexOf("<= /tbody>",""]||jQuery.browser.msie&&[1,"div","
"]||[0,"",""];div.innerHTML=3Dwrap[1]+arg+wrap[2];while(wrap[= 0]--)div=3Ddiv.lastChild;if(jQuery.browser.msie){if(!s.indexOf(""&&s.indexOf("=3D0;--n)if(jQuery.nodeName(tb[n],"tbody")&&!tb[n].chil= dNodes.length)tb[n].parentNode.removeChild(tb[n]);if(/^\s/.test(arg))div.= insertBefore(doc.createTextNode(arg.match(/^\s*/)[0]),div.firstChild);}ar= g=3DjQuery.makeArray(div.childNodes);}if(0=3D=3D=3Darg.length&&(!jQuery.n= odeName(arg,"form")&&!jQuery.nodeName(arg,"select")))return;if(arg[0]=3D=3D= undefined||jQuery.nodeName(arg,"form")||arg.options)r.push(arg);else=0A= r=3DjQuery.merge(r,arg);});return r;},attr:function(elem,name,value){var = fix=3DjQuery.isXMLDoc(elem)?{}:jQuery.props;if(name=3D=3D"selected"&&jQue= ry.browser.safari)elem.parentNode.selectedIndex;if(fix[name]){if(value!=3D= undefined)elem[fix[name]]=3Dvalue;return elem[fix[name]];}else = if(jQuery.browser.msie&&name=3D=3D"style")return = jQuery.attr(elem.style,"cssText",value);else = if(value=3D=3Dundefined&&jQuery.browser.msie&&jQuery.nodeName(elem,"form"= )&&(name=3D=3D"action"||name=3D=3D"method"))return = elem.getAttributeNode(name).nodeValue;else = if(elem.tagName){if(value!=3Dundefined){if(name=3D=3D"type"&&jQuery.nodeN= ame(elem,"input")&&elem.parentNode)throw"type property can't be = changed";elem.setAttribute(name,value);}if(jQuery.browser.msie&&/href|src= /.test(name)&&!jQuery.isXMLDoc(elem))return = elem.getAttribute(name,2);return = elem.getAttribute(name);}else{if(name=3D=3D"opacity"&&jQuery.browser.msie= ){if(value!=3Dundefined){elem.zoom=3D1;elem.filter=3D(elem.filter||"").re= place(/alpha\([^)]*\)/,"")+(parseFloat(value).toString()=3D=3D"NaN"?"":"a= lpha(opacity=3D"+value*100+")");}return = elem.filter?(parseFloat(elem.filter.match(/opacity=3D([^)]*)/)[1])/100).t= oString():"";}name=3Dname.replace(/-([a-z])/ig,function(z,b){return = b.toUpperCase();});if(value!=3Dundefined)elem[name]=3Dvalue;return = elem[name];}},trim:function(t){return(t||"").replace(/^\s+|\s+$/g,"");},m= akeArray:function(a){var r=3D[];if(typeof a!=3D"array")for(var = i=3D0,al=3Da.length;i\\s*("+chars+"+)"),quickID=3Dnew = RegExp("^("+chars+"+)(#)("+chars+"+)"),quickClass=3Dnew = RegExp("^([#.]?)("+chars+"*)");jQuery.extend({expr:{"":"m[2]=3D=3D'*'||jQ= uery.nodeName(a,m[2])","#":"a.getAttribute('id')=3D=3Dm[2]",":":{lt:"im[3]-0",nth:"m[3]-0=3D=3Di",eq:"m[3]-0=3D=3Di",first:"i=3D=3D= 0",last:"i=3D=3Dr.length-1",even:"i%2=3D=3D0",odd:"i%2","first-child":"a.= parentNode.getElementsByTagName('*')[0]=3D=3Da","last-child":"jQuery.nth(= a.parentNode.lastChild,1,'previousSibling')=3D=3Da","only-child":"!jQuery= .nth(a.parentNode.lastChild,2,'previousSibling')",parent:"a.firstChild",e= mpty:"!a.firstChild",contains:"(a.textContent||a.innerText||jQuery(a).tex= t()||'').indexOf(m[3])>=3D0",visible:'"hidden"!=3Da.type&&jQuery.css(a,"d= isplay")!=3D"none"&&jQuery.css(a,"visibility")!=3D"hidden"',hidden:'"hidd= en"=3D=3Da.type||jQuery.css(a,"display")=3D=3D"none"||jQuery.css(a,"visib= ility")=3D=3D"hidden"',enabled:"!a.disabled",disabled:"a.disabled",checke= d:"a.checked",selected:"a.selected||jQuery.attr(a,'selected')",text:"'tex= t'=3D=3Da.type",radio:"'radio'=3D=3Da.type",checkbox:"'checkbox'=3D=3Da.t= ype",file:"'file'=3D=3Da.type",password:"'password'=3D=3Da.type",submit:"= 'submit'=3D=3Da.type",image:"'image'=3D=3Da.type",reset:"'reset'=3D=3Da.t= ype",button:'"button"=3D=3Da.type||jQuery.nodeName(a,"button")',input:"/i= nput|select|textarea|button/i.test(a.nodeName)",has:"jQuery.find(m[3],a).= length",header:"/h\\d/i.test(a.nodeName)",animated:"jQuery.grep(jQuery.ti= mers,function(fn){return a=3D=3Dfn.elem;}).length"}},parse:[/^(\[) = *@?([\w-]+) *([!*$^~=3D]*) *('?"?)(.*?)\4 = *\]/,/^(:)([\w-]+)\("?'?(.*?(\(.*?\))?[^(]*?)"?'?\)/,new = RegExp("^([:.#]*)("+chars+"+)")],multiFilter:function(expr,elems,not){var= old,cur=3D[];while(expr&&expr!=3Dold){old=3Dexpr;var = f=3DjQuery.filter(expr,elems,not);expr=3Df.t.replace(/^\s*,\s*/,"");cur=3D= not?elems=3Df.r:jQuery.merge(cur,f.r);}return = cur;},find:function(t,context){if(typeof = t!=3D"string")return[t];if(context&&!context.nodeType)context=3Dnull;cont= ext=3Dcontext||document;var = ret=3D[context],done=3D[],last;while(t&&last!=3Dt){var = r=3D[];last=3Dt;t=3DjQuery.trim(t);var foundToken=3Dfalse;var = re=3DquickChild;var m=3Dre.exec(t);if(m){var = nodeName=3Dm[1].toUpperCase();for(var i=3D0;ret[i];i++)for(var = c=3Dret[i].firstChild;c;c=3Dc.nextSibling)if(c.nodeType=3D=3D1&&(nodeName= =3D=3D"*"||c.nodeName.toUpperCase()=3D=3DnodeName.toUpperCase()))r.push(c= );ret=3Dr;t=3Dt.replace(re,"");if(t.indexOf(" = ")=3D=3D0)continue;foundToken=3Dtrue;}else{re=3D/^([>+~])\s*(\w*)/i;if((m= =3Dre.exec(t))!=3Dnull){r=3D[];var = nodeName=3Dm[2],merge=3D{};m=3Dm[1];for(var = j=3D0,rl=3Dret.length;j=3D0)^not)tmp.= push(a);}r=3Dtmp;}else if(m[1]=3D=3D":"&&m[2]=3D=3D"nth-child"){var = merge=3D{},tmp=3D[],test=3D/(\d*)n\+?(\d*)/.exec(m[3]=3D=3D"even"&&"2n"||= m[3]=3D=3D"odd"&&"2n+1"||!/\D/.test(m[3])&&"n+"+m[3]||m[3]),first=3D(test= [1]||1)-0,last=3Dtest[2]-0;for(var i=3D0,rl=3Dr.length;i<\/script>");var = script=3Ddocument.getElementById("__ie_init");if(script)script.onreadysta= techange=3Dfunction(){if(this.readyState!=3D"complete")return;jQuery.read= y();};script=3Dnull;}else = if(jQuery.browser.safari)jQuery.safariTimer=3DsetInterval(function(){if(d= ocument.readyState=3D=3D"loaded"||document.readyState=3D=3D"complete"){cl= earInterval(jQuery.safariTimer);jQuery.safariTimer=3Dnull;jQuery.ready();= }},10);jQuery.event.add(window,"load",jQuery.ready);}jQuery.fn.extend({lo= ad:function(url,params,callback){if(jQuery.isFunction(url))return = this.bind("load",url);var off=3Durl.indexOf(" ");if(off>=3D0){var = selector=3Durl.slice(off,url.length);url=3Durl.slice(0,off);}callback=3Dc= allback||function(){};var = type=3D"GET";if(params)if(jQuery.isFunction(params)){callback=3Dparams;pa= rams=3Dnull;}else{params=3DjQuery.param(params);type=3D"POST";}var = self=3Dthis;jQuery.ajax({url:url,type:type,data:params,complete:function(= res,status){if(status=3D=3D"success"||status=3D=3D"notmodified")self.html= (selector?jQuery("
").append(res.responseText.replace(//g,"")).find(selector):res.responseText);setTimeout(function()= {self.each(callback,[res.responseText,status,res]);},13);}});return = this;},serialize:function(){return = jQuery.param(this.serializeArray());},serializeArray:function(){return = this.map(function(){return = jQuery.nodeName(this,"form")?jQuery.makeArray(this.elements):this;}).filt= er(function(){return = this.name&&!this.disabled&&(this.checked||/select|textarea/i.test(this.no= deName)||/text|hidden|password/i.test(this.type));}).map(function(i,elem)= {var val=3DjQuery(this).val();return = val=3D=3Dnull?null:val.constructor=3D=3DArray?jQuery.map(val,function(val= ,i){return{name:elem.name,value:val};}):{name:elem.name,value:val};}).get= ();}});jQuery.each("ajaxStart,ajaxStop,ajaxComplete,ajaxError,ajaxSuccess= ,ajaxSend".split(","),function(i,o){jQuery.fn[o]=3Dfunction(f){return = this.bind(o,f);};});var jsc=3D(new = Date).getTime();jQuery.extend({get:function(url,data,callback,type){if(jQ= uery.isFunction(data)){callback=3Ddata;data=3Dnull;}return = jQuery.ajax({type:"GET",url:url,data:data,success:callback,dataType:type}= );},getScript:function(url,callback){return = jQuery.get(url,null,callback,"script");},getJSON:function(url,data,callba= ck){return = jQuery.get(url,data,callback,"json");},post:function(url,data,callback,ty= pe){if(jQuery.isFunction(data)){callback=3Ddata;data=3D{};}return = jQuery.ajax({type:"POST",url:url,data:data,success:callback,dataType:type= });},ajaxSetup:function(settings){jQuery.extend(jQuery.ajaxSettings,setti= ngs);},ajaxSettings:{global:true,type:"GET",timeout:0,contentType:"applic= ation/x-www-form-urlencoded",processData:true,async:true,data:null},lastM= odified:{},ajax:function(s){var = jsonp,jsre=3D/=3D(\?|%3F)/g,status,data;s=3DjQuery.extend(true,s,jQuery.e= xtend(true,{},jQuery.ajaxSettings,s));if(s.data&&s.processData&&typeof = s.data!=3D"string")s.data=3DjQuery.param(s.data);if(s.dataType=3D=3D"json= p"){if(s.type.toLowerCase()=3D=3D"get"){if(!s.url.match(jsre))s.url+=3D(s= .url.match(/\?/)?"&":"?")+(s.jsonp||"callback")+"=3D?";}else = if(!s.data||!s.data.match(jsre))s.data=3D(s.data?s.data+"&":"")+(s.jsonp|= |"callback")+"=3D?";s.dataType=3D"json";}if(s.dataType=3D=3D"json"&&(s.da= ta&&s.data.match(jsre)||s.url.match(jsre))){jsonp=3D"jsonp"+jsc++;if(s.da= ta)s.data=3Ds.data.replace(jsre,"=3D"+jsonp);s.url=3Ds.url.replace(jsre,"= =3D"+jsonp);s.dataType=3D"script";window[jsonp]=3Dfunction(tmp){data=3Dtm= p;success();complete();window[jsonp]=3Dundefined;try{delete = window[jsonp];}catch(e){}};}if(s.dataType=3D=3D"script"&&s.cache=3D=3Dnul= l)s.cache=3Dfalse;if(s.cache=3D=3D=3Dfalse&&s.type.toLowerCase()=3D=3D"ge= t")s.url+=3D(s.url.match(/\?/)?"&":"?")+"_=3D"+(new = Date()).getTime();if(s.data&&s.type.toLowerCase()=3D=3D"get"){s.url+=3D(s= .url.match(/\?/)?"&":"?")+s.data;s.data=3Dnull;}if(s.global&&!jQuery.acti= ve++)jQuery.event.trigger("ajaxStart");if(!s.url.indexOf("http")&&s.dataT= ype=3D=3D"script"){var = head=3Ddocument.getElementsByTagName("head")[0];var = script=3Ddocument.createElement("script");script.src=3Ds.url;if(!jsonp&&(= s.success||s.complete)){var = done=3Dfalse;script.onload=3Dscript.onreadystatechange=3Dfunction(){if(!d= one&&(!this.readyState||this.readyState=3D=3D"loaded"||this.readyState=3D= =3D"complete")){done=3Dtrue;success();complete();head.removeChild(script)= ;}};}head.appendChild(script);return;}var requestDone=3Dfalse;var = xml=3Dwindow.ActiveXObject?new ActiveXObject("Microsoft.XMLHTTP"):new = XMLHttpRequest();xml.open(s.type,s.url,s.async);if(s.data)xml.setRequestH= eader("Content-Type",s.contentType);if(s.ifModified)xml.setRequestHeader(= "If-Modified-Since",jQuery.lastModified[s.url]||"Thu, 01 Jan 1970 = 00:00:00 = GMT");xml.setRequestHeader("X-Requested-With","XMLHttpRequest");if(s.befo= reSend)s.beforeSend(xml);if(s.global)jQuery.event.trigger("ajaxSend",[xml= ,s]);var = onreadystatechange=3Dfunction(isTimeout){if(!requestDone&&xml&&(xml.ready= State=3D=3D4||isTimeout=3D=3D"timeout")){requestDone=3Dtrue;if(ival){clea= rInterval(ival);ival=3Dnull;}status=3DisTimeout=3D=3D"timeout"&&"timeout"= ||!jQuery.httpSuccess(xml)&&"error"||s.ifModified&&jQuery.httpNotModified= (xml,s.url)&&"notmodified"||"success";if(status=3D=3D"success"){try{data=3D= jQuery.httpData(xml,s.dataType);}catch(e){status=3D"parsererror";}}if(sta= tus=3D=3D"success"){var = modRes;try{modRes=3Dxml.getResponseHeader("Last-Modified");}catch(e){}if(= s.ifModified&&modRes)jQuery.lastModified[s.url]=3DmodRes;if(!jsonp)succes= s();}else=0A= jQuery.handleError(s,xml,status);complete();if(s.async)xml=3Dnull;}};if(s= .async){var = ival=3DsetInterval(onreadystatechange,13);if(s.timeout>0)setTimeout(funct= ion(){if(xml){xml.abort();if(!requestDone)onreadystatechange("timeout");}= },s.timeout);}try{xml.send(s.data);}catch(e){jQuery.handleError(s,xml,nul= l,e);}if(!s.async)onreadystatechange();return xml;function = success(){if(s.success)s.success(data,status);if(s.global)jQuery.event.tr= igger("ajaxSuccess",[xml,s]);}function = complete(){if(s.complete)s.complete(xml,status);if(s.global)jQuery.event.= trigger("ajaxComplete",[xml,s]);if(s.global&&!--jQuery.active)jQuery.even= t.trigger("ajaxStop");}},handleError:function(s,xml,status,e){if(s.error)= s.error(xml,status,e);if(s.global)jQuery.event.trigger("ajaxError",[xml,s= ,e]);},active:0,httpSuccess:function(r){try{return!r.status&&location.pro= tocol=3D=3D"file:"||(r.status>=3D200&&r.status<300)||r.status=3D=3D304||j= Query.browser.safari&&r.status=3D=3Dundefined;}catch(e){}return = false;},httpNotModified:function(xml,url){try{var = xmlRes=3Dxml.getResponseHeader("Last-Modified");return = xml.status=3D=3D304||xmlRes=3D=3DjQuery.lastModified[url]||jQuery.browser= .safari&&xml.status=3D=3Dundefined;}catch(e){}return = false;},httpData:function(r,type){var = ct=3Dr.getResponseHeader("content-type");var = xml=3Dtype=3D=3D"xml"||!type&&ct&&ct.indexOf("xml")>=3D0;var = data=3Dxml?r.responseXML:r.responseText;if(xml&&data.documentElement.tagN= ame=3D=3D"parsererror")throw"parsererror";if(type=3D=3D"script")jQuery.gl= obalEval(data);if(type=3D=3D"json")data=3Deval("("+data+")");return = data;},param:function(a){var = s=3D[];if(a.constructor=3D=3DArray||a.jquery)jQuery.each(a,function(){s.p= ush(encodeURIComponent(this.name)+"=3D"+encodeURIComponent(this.value));}= );else=0A= for(var j in = a)if(a[j]&&a[j].constructor=3D=3DArray)jQuery.each(a[j],function(){s.push= (encodeURIComponent(j)+"=3D"+encodeURIComponent(this));});else=0A= s.push(encodeURIComponent(j)+"=3D"+encodeURIComponent(a[j]));return = s.join("&").replace(/%20/g,"+");}});jQuery.fn.extend({show:function(speed= ,callback){return = speed?this.animate({height:"show",width:"show",opacity:"show"},speed,call= back):this.filter(":hidden").each(function(){this.style.display=3Dthis.ol= dblock?this.oldblock:"";if(jQuery.css(this,"display")=3D=3D"none")this.st= yle.display=3D"block";}).end();},hide:function(speed,callback){return = speed?this.animate({height:"hide",width:"hide",opacity:"hide"},speed,call= back):this.filter(":visible").each(function(){this.oldblock=3Dthis.oldblo= ck||jQuery.css(this,"display");if(this.oldblock=3D=3D"none")this.oldblock= =3D"block";this.style.display=3D"none";}).end();},_toggle:jQuery.fn.toggl= e,toggle:function(fn,fn2){return = jQuery.isFunction(fn)&&jQuery.isFunction(fn2)?this._toggle(fn,fn2):fn?thi= s.animate({height:"toggle",width:"toggle",opacity:"toggle"},fn,fn2):this.= each(function(){jQuery(this)[jQuery(this).is(":hidden")?"show":"hide"]();= });},slideDown:function(speed,callback){return = this.animate({height:"show"},speed,callback);},slideUp:function(speed,cal= lback){return = this.animate({height:"hide"},speed,callback);},slideToggle:function(speed= ,callback){return = this.animate({height:"toggle"},speed,callback);},fadeIn:function(speed,ca= llback){return = this.animate({opacity:"show"},speed,callback);},fadeOut:function(speed,ca= llback){return = this.animate({opacity:"hide"},speed,callback);},fadeTo:function(speed,to,= callback){return = this.animate({opacity:to},speed,callback);},animate:function(prop,speed,e= asing,callback){var opt=3DjQuery.speed(speed,easing,callback);return = this[opt.queue=3D=3D=3Dfalse?"each":"queue"](function(){opt=3DjQuery.exte= nd({},opt);var hidden=3DjQuery(this).is(":hidden"),self=3Dthis;for(var p = in = prop){if(prop[p]=3D=3D"hide"&&hidden||prop[p]=3D=3D"show"&&!hidden)return= = jQuery.isFunction(opt.complete)&&opt.complete.apply(this);if(p=3D=3D"heig= ht"||p=3D=3D"width"){opt.display=3DjQuery.css(this,"display");opt.overflo= w=3Dthis.style.overflow;}}if(opt.overflow!=3Dnull)this.style.overflow=3D"= hidden";opt.curAnim=3DjQuery.extend({},prop);jQuery.each(prop,function(na= me,val){var e=3Dnew = jQuery.fx(self,opt,name);if(/toggle|show|hide/.test(val))e[val=3D=3D"togg= le"?hidden?"show":"hide":val](prop);else{var = parts=3Dval.toString().match(/^([+-]=3D)?([\d+-.]+)(.*)$/),start=3De.cur(= true)||0;if(parts){var = end=3DparseFloat(parts[2]),unit=3Dparts[3]||"px";if(unit!=3D"px"){self.st= yle[name]=3D(end||1)+unit;start=3D((end||1)/e.cur(true))*start;self.style= [name]=3Dstart+unit;}if(parts[1])end=3D((parts[1]=3D=3D"-=3D"?-1:1)*end)+= start;e.custom(start,end,unit);}else=0A= e.custom(start,val,"");}});return = true;});},queue:function(type,fn){if(jQuery.isFunction(type)){fn=3Dtype;t= ype=3D"fx";}if(!type||(typeof type=3D=3D"string"&&!fn))return = queue(this[0],type);return = this.each(function(){if(fn.constructor=3D=3DArray)queue(this,type,fn);els= e{queue(this,type).push(fn);if(queue(this,type).length=3D=3D1)fn.apply(th= is);}});},stop:function(){var timers=3DjQuery.timers;return = this.each(function(){for(var = i=3D0;i-10000?r:parseFloat(jQuery.css(this.elem,this.prop))||0;},custom:fun= ction(from,to,unit){this.startTime=3D(new = Date()).getTime();this.start=3Dfrom;this.end=3Dto;this.unit=3Dunit||this.= unit||"px";this.now=3Dthis.start;this.pos=3Dthis.state=3D0;this.update();= var self=3Dthis;function t(){return = self.step();}t.elem=3Dthis.elem;jQuery.timers.push(t);if(jQuery.timers.le= ngth=3D=3D1){var timer=3DsetInterval(function(){var = timers=3DjQuery.timers;for(var = i=3D0;ithis.options.duration+this.startTime){this.now=3Dt= his.end;this.pos=3Dthis.state=3D1;this.update();this.options.curAnim[this= .prop]=3Dtrue;var done=3Dtrue;for(var i in = this.options.curAnim)if(this.options.curAnim[i]!=3D=3Dtrue)done=3Dfalse;i= f(done){if(this.options.display!=3Dnull){this.elem.style.overflow=3Dthis.= options.overflow;this.elem.style.display=3Dthis.options.display;if(jQuery= .css(this.elem,"display")=3D=3D"none")this.elem.style.display=3D"block";}= if(this.options.hide)this.elem.style.display=3D"none";if(this.options.hid= e||this.options.show)for(var p in = this.options.curAnim)jQuery.attr(this.elem.style,p,this.options.orig[p]);= }if(done&&jQuery.isFunction(this.options.complete))this.options.complete.= apply(this.elem);return false;}else{var = n=3Dt-this.startTime;this.state=3Dn/this.options.duration;this.pos=3DjQue= ry.easing[this.options.easing||(jQuery.easing.swing?"swing":"linear")](th= is.state,n,0,1,this.options.duration);this.now=3Dthis.start+((this.end-th= is.start)*this.pos);this.update();}return = true;}};jQuery.fx.step=3D{scrollLeft:function(fx){fx.elem.scrollLeft=3Dfx= .now;},scrollTop:function(fx){fx.elem.scrollTop=3Dfx.now;},opacity:functi= on(fx){jQuery.attr(fx.elem.style,"opacity",fx.now);},_default:function(fx= ){fx.elem.style[fx.prop]=3Dfx.now+fx.unit;}};jQuery.fn.offset=3Dfunction(= ){var = left=3D0,top=3D0,elem=3Dthis[0],results;if(elem)with(jQuery.browser){var = absolute=3DjQuery.css(elem,"position")=3D=3D"absolute",parent=3Delem.pare= ntNode,offsetParent=3Delem.offsetParent,doc=3Delem.ownerDocument,safari2=3D= safari&&parseInt(version)<522;if(elem.getBoundingClientRect){box=3Delem.g= etBoundingClientRect();add(box.left+Math.max(doc.documentElement.scrollLe= ft,doc.body.scrollLeft),box.top+Math.max(doc.documentElement.scrollTop,do= c.body.scrollTop));if(msie){var = border=3DjQuery("html").css("borderWidth");border=3D(border=3D=3D"medium"= ||jQuery.boxModel&&parseInt(version)>=3D7)&&2||border;add(-border,-border= );}}else{add(elem.offsetLeft,elem.offsetTop);while(offsetParent){add(offs= etParent.offsetLeft,offsetParent.offsetTop);if(mozilla&&/^t[d|h]$/i.test(= parent.tagName)||!safari2)border(offsetParent);if(safari2&&!absolute&&jQu= ery.css(offsetParent,"position")=3D=3D"absolute")absolute=3Dtrue;offsetPa= rent=3DoffsetParent.offsetParent;}while(parent.tagName&&!/^body|html$/i.t= est(parent.tagName)){if(!/^inline|table-row.*$/i.test(jQuery.css(parent,"= display")))add(-parent.scrollLeft,-parent.scrollTop);if(mozilla&&jQuery.c= ss(parent,"overflow")!=3D"visible")border(parent);parent=3Dparent.parentN= ode;}if(safari2&&absolute)add(-doc.body.offsetLeft,-doc.body.offsetTop);}= results=3D{top:top,left:left};}return results;function = border(elem){add(jQuery.css(elem,"borderLeftWidth"),jQuery.css(elem,"bord= erTopWidth"));}function = add(l,t){left+=3DparseInt(l)||0;top+=3DparseInt(t)||0;}};})(); ------=_NextPart_000_0000_01C8B1D0.A3459760 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/scripts/global.js (function($) { $(document).ready(function () { // enables dropdown ads to display whilst maintaining .user-services = visibility aat small resolutions // yes, it involves browser detection, and yes, that is truly = horrible. if (jQuery.browser.mozilla) { =09 var dropdownAd =3D false; =09 // for each descendant of .leaderboard that isn't a