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The Oncologist, Vol. 11, No. 6, 681-693, June 2006;=20 doi:10.1634/theoncologist.11-6-681
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Neuro-Oncology

Low-Grade Gliomas in Adults

Jeanine T.=20 Grier, Tracy Batchelor =

Division of Neuro-Oncology, Department of Neurology,=20 Massachusetts General Hospital and Harvard Medical School, Boston,=20 Massachusetts, USA

Key Words. Low-grade glioma =95 Astrocytoma =95=20 Oligodendroglioma

Correspondence: Tracy Batchelor, M.D., M.P.H., Stephen E. and = Catherine=20 Pappas Center for Neuro-Oncology, Yawkey 9E, Massachusetts General = Hospital, 55=20 Fruit Street, Boston, Massachusetts 02114, USA. Telephone: 617-643-1938; = Fax:=20 617-643-2591; e-mail: tbatchelor{at}partners.org

Received January 4, 2006; accepted for publication April 18, 2006.


3D"    LEARNING OBJECTIVES=20
Top
3D"Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
A= fter=20 completing this course, the reader will be able to:

  1. Discuss the incidence of low-grade gliomas and list the = various diagnostic methods employed for this = group of=20 tumors.
  2. Identify the factors that influence treatment decisions = and the various treatment options available for=20 low-grade gliomas.
  3. Outline the evidence regarding resection, radiation, = and=20 chemotherapy for the treatment of low-grade=20 gliomas.
  4. List the specific subsets of low-grade glioma and the=20 unique diagnostic, prognostic, and treatment = factors=20 associated with each subset.
  5. Describe the different treatment-related complications=20 that are relevant for the low-grade glioma = patient=20 population.

Access and take the CME test online and receive 1 AMA PRA = category=20 1 credit at CME.TheOncologist.com =


3D"    ABSTRACT
Top
Learning Objectives
3D"Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
<= STRONG>Low-grade=20 gliomas are a heterogeneous group of neoplasms usually = encountered in=20 younger patient populations. These tumors represent a unique=20 challenge because most patients will survive a decade or more = and may=20 be at a higher risk for treatment-related complications. = Clinical=20 observations over the years have identified a subset of = low-grade=20 gliomas that tends to manifest more aggressive clinical = behavior and=20 require earlier, more aggressive intervention. Clinical and = molecular=20 parameters may allow better assessment of prognosis and = application=20 of risk-adjusted management strategies that may include = resection,=20 radiation, or chemotherapy. Improved methods of long-term = cognitive=20 and functional assessment are desperately needed in this = patient=20 population.


3D"    INTRODUCTION
Top
Learning Objectives
Abstract
3D"Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
T= umors of=20 the central nervous system (CNS) are grouped according to = their cell=20 of origin and are graded based on standard histopathological=20 features. Gliomas comprise a heterogeneous group of = neuroectodermal=20 tumors that arise from the glia, the supporting cells of the=20 CNS. Astrocytes, oligodendrocytes, and ependymal cells are = types=20 of glial cells that may give rise to astrocytomas,=20 oligodendrogliomas, and ependymomas, respectively. =

According to the World Health Organization (WHO) classification, = the most commonly accepted grading system for brain tumors, = the=20 surgical specimen should be assessed for atypical cells, = mitoses,=20 endothelial proliferation, and necrosis. Tumors with none of = these=20 characteristics are classified as grade 1. The more common = gliomas in=20 this class are pilocytic astrocytoma (PA), dysembryoplastic=20 neuroepithelial tumor (DNET), pleomorphic xanthoastrocytoma = (PXA),=20 and ganglioglioma. Gliomas that possess only one feature, = usually=20 atypical cells, are grade 2. Astrocytoma, oligodendroglioma, = and=20 oligoastrocytoma fall into the grade 2 category. These tumors = are=20 also termed low-grade astrocytoma, low-grade = oligodendroglioma, and=20 low-grade oligoastrocytoma, respectively. A subset of gliomas = may=20 have both endothelial proliferation and atypia but are well=20 circumscribed and slow-growing. These tumors are considered = to be=20 low-grade gliomas (LGGs) despite their departure from the = typical=20 classification scheme. LGG refers to tumors in either the = grade 1 or=20 grade 2 categories. Tumors with two or more features are = considered=20 malignant and are termed grade 3 or grade 4 gliomas. =

LGGs include a diverse group of tumors within the brain, = brainstem,=20 and spinal cord, with distinct characteristics, patterns of=20 occurrence, response to treatment, and survival. Patients = with=20 LGG tend to be young, otherwise healthy individuals, and = management=20 decisions, such as timing of intervention, extent of surgical = resection, timing of radiotherapy, and long-term benefits and = risks of chemotherapy, have been controversial. In this = review,=20 we outline the key issues of LGG management. For the purpose = of=20 this review, LGG refers only to supratentorial nonpilocytic=20 astrocytoma, oligodendroglioma, and mixed oligoastrocytoma.=20 Other subtypes=97such as pilocytic astrocytoma, subependymal=20 giant cell astrocytoma, brainstem glioma, and optic nerve = glioma=97have=20 different clinical presentations, diagnostic algorithms, and=20 treatments. These four subtypes are briefly discussed at the=20 end of this review.


3D"    INCIDENCE
Top
Learning Objectives
Abstract
Introduction
3D"Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
A= n=20 estimated 43,800 new cases of primary CNS tumors were diagnosed = in=20 2005 [1].=20 Gliomas accounted for 40% of all these primary CNS tumors [1].=20 Astrocytomas represent 75% of all gliomas, while ependymomas, = oligodendrogliomas, and other glioma subtypes comprise the = remaining=20 25%. The International Classification of Diseases for = Oncology=20 (ICDO)-3 does not identify separate histology codes for = low-grade=20 gliomas [2].=20 Since no ICDO-3 codes exist for LGG, specific incidence rates = for=20 low-grade oligodendroglioma and low-grade astrocytoma are = difficult=20 to determine. From a compilation of citations, the American=20 Association of Neurological Surgeons (AANS) estimated that = the annual=20 number of pediatric and adult LGG cases diagnosed in the = U.S.,=20 including pilocytic astrocytoma, diffuse fibrillary = astrocytoma,=20 oligodendroglioma, and oligoastrocytoma, is 1,800 [3].=20

In adults aged 20=9634, gliomas account for 45% of all CNS = tumors.=20 Astrocytomas as a group account for 18% and glioblastoma = accounts for=20 6% of young adult tumors [1].=20 Incidence rates for glioblastoma, ependymoma, mixed glioma, = and=20 oligodendroglioma are over two times greater in whites than = in blacks=20 [1].=20 Currently, there is no compelling evidence for a strong = association=20 between environmental exposures and glioma development [4].=20


3D"    PRESENTATION
Top
Learning Objectives
Abstract
Introduction
Incidence
3D"Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
M= ost=20 patients with LGG present between the second and fourth = decades of=20 life, and a seizure is the presenting symptom in 72%=9689% of = patients=20 [5=9612].=20 Mental status changes are present in 3%=9630% of patients at = the time=20 of presentation [6,=20 10,=20 12].=20 Ten percent to 44% have signs of increased intracranial = pressure,=20 such as headache and nausea, when first diagnosed [6,=20 10,=20 11].=20 Focal neurological deficits are present in 2%=9630% of = patients [6,=20 7].=20 However, patients may have normal neurological = examinations.=20


3D"    DIAGNOSIS
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
3D"Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
D= iagnosis=20 is made through radiological imaging and histopathology. On=20 contrast-enhanced computerized tomography (CT) scans, an LGG = usually=20 appears as a heterogeneous region of low attenuation that may = or may=20 not enhance. There may be mass effect on adjacent structures, = and=20 calcifications occur in up to 20% of oligodendrogliomas but = are less=20 common in astrocytomas [13].=20 On magnetic resonance imaging (MRI), LGGs are usually = nonenhancing=20 with low signal intensity on T1-weighted (Fig. 1A) and high signal intensity on = T2-weighted MRI=20 sequences. Calcifications may appear as foci of high T1 and = low T2=20 signals. Fluid-attenuated inversion recovery (FLAIR) = sequences show=20 the best contrast between presumed infiltrating tumor margins = and=20 normal brain (Fig. 1B).



View = larger=20 version (73K):
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  		Figure 1. Low-grade = astrocytoma.=20 (A): T1-weighted, postcontrast, axial magnetic = resonance=20 image of a patient with a right temporal low-grade = astrocytoma. The=20 tumor is dark without evidence of enhancement. (B): = Axial=20 fluid-attenuated inversion recovery image of the same = patient as in=20 (A) showing a bright signal abnormality in the right=20 hemisphere. =

 = ;
LGGs=20 may enhance on neuroimaging studies. Conversely, the absence = of=20 enhancement does not always signify low-grade histopathology = since up=20 to one third of nonenhancing diffuse gliomas in adults are = high grade=20 [14,=20 15].=20 These tumors are also highly infiltrative, and one must = assume that=20 tumor cells extend beyond the radiographic border of the = lesion [14,=20 16,=20 17].=20 Pirzkall et al. [13]=20 demonstrated that metabolically active tumor is restricted = mainly to=20 the T2 hyperintensity in LGG, but can extend beyond the T2=20 border for up to 2 cm. LGG are characteristically located in=20 white matter, but these tumors may also infiltrate into gray=20 matter.

Histopathology
Histopathological evaluation of = tumor=20 tissue remains the standard method for diagnosis and = classification=20 of glioma (Fig. 2), but diagnostic challenges are = well=20 recognized, including subjective criteria, tissue sampling = error, and=20 lack of specific tumor markers [16,=20 18=9624].=20 In general, lesions detected on CT or MRI scans that could be = consistent with a brain tumor should prompt neurosurgical=20 consultation with a goal of achieving a tissue diagnosis. = Exceptions=20 might include lesions in critical locations, such as the = brainstem,=20 in which case a biopsy or resection is not possible. A = stereotactic=20 biopsy is often performed on an awake patient positioned in a = stereotactic frame, over which an MRI or CT scan is obtained = to=20 compute the exact coordinates of the lesion. A small burr = hole is=20 made in the skull, through which several small tissue core = samples=20 are collected. In contrast, a craniotomy is performed under = general=20 anesthesia and allows the surgeon to obtain a specimen for = diagnostic=20 purposes as well as to resect the tumor and relieve mass = effects,=20 thereby gaining some therapeutic benefit.



View = larger=20 version (80K):
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  		Figure 2. Histopathology = of=20 low-grade gliomas. (A): A hematoxylineosin stain of a = typical=20 World Health Organization grade 2 astrocytoma with increased = cellularity and pleomorphism. This two-stage stain consists = of=20 hematoxylin followed by a counterstain of red eosin so that = the=20 nuclei stain a deep blue-black and the cytoplasm stains = pink.=20 Magnification, 400x. = Courtesy of=20 David N. Louis, M.D., Department of Pathology, Massachusetts = General=20 Hospital. (B): Oligodendroglioma. High-power imaging=20 demonstrates the classic appearance of a low-grade = oligodendroglioma=20 in hematoxylineosin stain. Note the well-defined cell walls, = clear=20 cytoplasm, and prominent nuclei. Magnification, 400x. Courtesy of David N.Louis, = M.D.,=20 Department of Pathology, Massachusetts General Hospital. =

 = ;
A=20 number of factors are considered when choosing between a = stereotactic=20 biopsy and craniotomy for resection [25].=20 Indications for stereotactic biopsy include: a deep-seated = location=20 not amenable to resection, ambiguous radiological and = clinical=20 information (i.e., the lesion might not be a tumor), a change = in=20 appearance of a previously diagnosed and treated tumor, = multiple or=20 diffuse lesions, an appearance that suggests lymphoma (which = would=20 not require resection), and finally, if the patient is not = clinically=20 stable enough to tolerate a craniotomy [26].=20 As mentioned above, because of the morphological = heterogeneity of=20 gliomas, stereotactic biopsy is limited by sampling error and = may=20 miss a higher grade component of a mixed lesion [16,=20 17,=20 27=9629].=20 Perfusion-weighted imaging may provide a useful guide as to = which=20 area of the LGG should be targeted for biopsy in an effort to = reduce=20 sampling error [30,=20 31].=20 Even with improved selection of a biopsy zone, the = reproducibility of=20 grading between two observers is lower for low-grade than for = high-grade astrocytomas [32].=20 The benefits of a craniotomy include more accurate diagnosis = based on=20 full tissue evaluation, alleviation of mass effects, and=20 possible treatment, all in one operation.

Molecular Markers
Genetic testing should be = strongly=20 considered for all low-grade oligodendrogliomas (LGOs) and=20 oligoastrocytomas (LGOAs). Over the past decade, it has been = shown=20 that specific genetic markers are helpful in dividing gliomas = into=20 subgroups with respect to prognosis and response to = chemotherapy.=20 Oligodendroglial tumors frequently show loss of = heterozygosity (LOH)=20 on chromosomes 1p and 19q, reported in 50%=9670% of both = low-grade=20 and anaplastic tumors [33,=20 34].=20 LOH for 1p or LOH for both 1p and 19q is predictive of=20 chemosensitivity and longer survival in patients with = anaplastic=20 oligodendrogliomas [35].=20 Loss of 1p and 19q has also been shown to be a favorable = prognostic=20 marker in LGO and LGOA [36,=20 37].=20 In a study of LGOs treated with temozolomide, there was a = higher=20 likelihood of responding to temozolomide, an oral methylating = drug,=20 if there was LOH for 1p [38].=20 Smith et al. [24]=20 showed that combined loss of 1p and 19q is a statistically=20 significant predictor of prolonged survival in patients with=20 oligodendroglioma, independent of tumor grade.

Immunohistochemical Markers
Another proposed = prognostic=20 indicator is an immunohistochemical stain for = proliferation-related=20 nuclear markers, the Ki-67 antigen, or the MIB-1 antibody, = both=20 reactive against the Ki-67 nuclear antigen [39].=20 Immunohistochemistry for the Ki-67 antigen provides = prognostic=20 information that is independent of histopathologic grading = and tumor=20 localization [40].=20 Diffuse grade 2 astrocytoma typically has a Ki-67/MIB-1 of = 1%=962%,=20 whereas WHO grade 4 astrocytoma often has a labeling index of = 15%=9620%=20 [41].=20 Age at diagnosis, extent of resection, postoperative = performance=20 status, and MIB-1 were all associated with survival in one = study=20 of oligodendrogliomas and oligoastrocytomas [42].=20 Significant differences in survival were found when patients = with=20 oligodendroglioma and oligoastrocytoma were separated into = two groups=20 based on whether their Ki-67/MIB-1 is 3D≤=205% = or >5%=20 [43].=20 Despite this evidence, there are still conflicting opinions = on the=20 prognostic relevance of Ki-67/MIB-1 in LGG.


3D"    TREATMENT
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
3D"Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
M= anagement=20 of LGG is controversial because these patients are typically = younger,=20 with few, if any, neurological symptoms. Historically, when = LGG was=20 diagnosed in a young, healthy adult, a commonly accepted = strategy was=20 a "watch and wait" approach because of the indolent nature = and=20 variable behavior of these tumors. The support for this = practice came=20 from several retrospective studies showing that, when therapy = was=20 deferred, patients had no difference in outcome (survival, = quality of=20 life [QoL]) from time of radiologic diagnosis [7,=20 11,=20 44].=20 There was also a belief that LGGs did not necessarily = transform into=20 malignant tumors over time. However, the latter notion has = been=20 refuted. In retrospective studies of the kinetics of glioma = growth,=20 continuous growth was seen in the premalignant phase before=20 anaplastic transformation [45].=20 The majority of LGGs are now known to progress to malignant = gliomas=20 with time. A better understanding of the natural history of = LGGs has=20 led to an interest in earlier treatment.

The decision as to whether a patient with LGG should receive=20 resection, radiation therapy (RT), or chemotherapy is based = on=20 a number of factors including age, performance status, location = of=20 tumor, and patient preference. Since LGGs are such a heterogeneous=20 group of tumors with variable natural histories, the risks = and=20 benefits of each of the three therapies must be carefully = balanced=20 with the data available from limited prospective studies. =

Surgery
Tumor location determines resectability = of LGGs.=20 Tumors located in critical areas of the brain are typically=20 nonresectable. For those LGGs that can be resected, the = important=20 question becomes how much tissue to resect in order to = prolong=20 survival, alleviate symptoms, and minimize the risk for = neurological=20 injury. Because there have been no randomized trials to = determine=20 the benefit of extensive resection of LGGs, current surgical=20 management of these tumors is based on retrospective studies, = expert=20 opinion, or case reports [9,=20 46=9649].=20 In the early 1990s Berger et al. [48]=20 analyzed preoperative and postoperative radiographic tumor = volumes in=20 53 patients to evaluate whether the percentage of resection = and=20 volume of postoperative residual disease influenced the = incidence of=20 recurrence, time to tumor progression, or histology of the = recurrent=20 tumor. This retrospective study found that, in patients with=20 preoperative tumor volumes <10 cm3, no recurrence = was=20 detected over a 3- to 4-year span, regardless of percent of = resection=20 and volume of residual disease [48].=20 All patients with a complete gross resection were recurrence = free at=20 a mean follow-up period of 54 months. In the remaining 40=20 patients, the percentage of resection was found to be = inversely=20 correlated with the incidence of recurrence, and there was = also a=20 shorter time to tumor progression in those with a larger = volume of=20 residual tumor [48].=20

Leighton and coworkers [50]=20 retrospectively reviewed the records of 167 adults with LGGs = and=20 found that minimal residual tumor after surgery was = associated with a=20 significantly longer survival time in both univariate and=20 multivariate analyses. In 2001, Keles et al. [47]=20 conducted a comprehensive literature review to evaluate the=20 prognostic effect of extent of resection and to determine if=20 treatment-related guidelines could be established for the = management=20 of LGG. Of 30 studies that included statistical analyses and = were=20 published over a 30-year period (1970=962000), only five = satisfied=20 methodological criteria outlined by the authors. In all five = studies=20 the prognostic effect of extent of resection was found to be=20 statistically significant by univariate analysis. In = addition, the=20 extent of resection was a significant prognostic factor by=20 multivariate analysis in four studies [47].=20 It is not possible to quantify or eliminate the strong = possibility=20 of confounding and selection bias in these retrospective = studies.=20 Nevertheless, these observations represent the best = information=20 available at the present time regarding this topic.

Currently, the standard approach is to perform a gross total=20 resection if technically possible[20,=20 49].=20 The risks and benefits must be weighed carefully because the = surgical=20 intervention itself may result in a transient or permanent = decline in=20 neurological function [51].=20 Surgical debulking is often recommended for any patient with=20 increased intracranial pressure, neurological deficits = related to=20 mass effects, or uncontrollable seizures. It is important for = the=20 patient to understand that gross total resection does not = mean the=20 tumor has been completely removed [52].=20 LGGs are infiltrative tumors with indistinct borders and=20 microscopic invasion beyond the radiographic margins. In the = majority=20 of cases, the area of tumor resection may be stable for years = until a recurrence is detected by symptoms or imaging [5,=20 52].=20 The recurrence may occur in the same area as the prior tumor = or=20 in a separate location. Regular clinical and radiographic = monitoring=20 are essential in postoperative management.

Radiation
The critical questions regarding RT for = patients with LGG are: timing, effective dose, and how to = weigh the=20 benefit of tumor control against potential toxicity [10,=20 50,=20 53=9656].=20 Three prospective randomized clinical trials have been = conducted=20 to address these questions.

The first randomized trial was conducted by the European = Organization=20 for Research and Treatment of Cancer (EORTC, trial 22844) to=20 determine if a radiation dose response exists for LGG. In = that=20 study, 379 adults with LGG were randomized to receive = different=20 doses and schedules of RT after biopsy or resection, 45 Gy in = 5=20 weeks versus 59.4 Gy in 6.6 weeks. There were no significant=20 differences in progression-free or overall survival times = between=20 the two groups. Other findings of the EORTC 22844 trial = included=20 age as a significant prognostic factor for overall survival,=20 but not progression-free survival, while the size of tumor, = or=20 "T" of the TNM classifications, appeared to be one of the = most=20 important prognostic factors on multivariate analysis [57,=20 58].=20

A second randomized trial, EORTC 22845, compared immediate RT = for=20 cerebral LGG in adults with RT after recurrence. In that = study, 311=20 adult patients from 24 European centers were randomized after = surgery=20 to receive either 54 Gy in 1.8-Gy fractions over 6 weeks or = no=20 radiation until evidence of tumor progression was identified = on=20 imaging or suggested by neurological deterioration [59].=20 Postoperative CT scans were not routinely performed in that = study,=20 thus the residual amount of tumor could not be assessed. = Twenty-two=20 percent of the 232 tumors that were submitted for central=20 pathological review in EORTC 22845 were reclassified as = high-grade=20 gliomas after being reviewed, and 3.4% were reclassified as=20 ineligible tumors based on study protocol. Overall survival = and time=20 to progression were primary end points. Although overall = survival at=20 5 years did not differ between the two groups, the median=20 progression-free survival time was 5.3 years for the group = receiving=20 immediate RT versus 3.4 years for those with RT deferred [60].=20 In addition, seizures were better controlled in the early RT = group.=20 This study represents the first randomized trial to compare = an active=20 treatment with the "watch and wait" approach. Although = immediate=20 postoperative irradiation increased the median = progression-free=20 survival time by nearly 2 years, it is not clear whether = longer=20 progression-free survival represents better QoL.

The results of EORTC 22844 were partially confirmed in a = randomized=20 trial by the North Central Cancer Treatment Group = (NCCTG)/Radiation=20 Therapy Oncology Group/Eastern Cooperative Oncology Group [61].=20 In that study, 203 patients were randomized to receive either = low-dose RT (50.4 Gy in 28 fractions) or high-dose RT (64.8 = Gy=20 in 36 fractions). These low and high doses differed from = those used=20 in the EORTC study. Of these 203 patients, 103 had undergone = biopsy,=20 71 had subtotal resections, and 29 had gross total resections = before=20 starting RT. In addition, 139 patients had oligodendroglioma = or mixed=20 oligoastrocytoma (mainly oligodendrocytic), while 64 patients = had=20 astrocytoma or mixed oligoastrocytoma (mainly astrocytic).=20 Interpretation of these results is limited by this tumor=20 heterogeneity. However, this study did not find an advantage = for=20 high-dose over low-dose RT in adults with supratentorial LGG = in terms=20 of overall survival or time to progression [61].=20 The currently accepted treatment for LGG includes a radiation = dose of 50=9654 Gy in fractions of 1.8 Gy to the tumor bed = as=20 well as a 1- to 2-cm surrounding margin.

In a small prospective study of whether RT was needed = postoperatively,=20 18 patients with resected LGOs were managed with follow-up = alone=20 if full resection was achieved or chemotherapy if the tumor = was=20 incompletely resected [54].=20 In that study, all patients were alive and 94% were = progression free=20 after a median follow-up of 4.7 years, with no use of RT. = Similar=20 findings in other studies have led some to recommend RT for = young=20 patients only if there is recurrence of tumor and not in the=20 immediate postoperative stage [62]=20 because of the possible neurotoxic effects in long-term = survivors [56].=20 However, there has not been a randomized trial using = percentage of=20 surgical resection to clarify this treatment = recommendation.=20

Since the time of these original prospective studies, there = have=20 been major technical advances in the delivery of radiation. = There is=20 now computer optimization and intensity-modulated radiotherapy=20 (IMRT), which allow different levels of intensity across a = lesion=20 [63].=20 In addition, functional imaging such as positron- emission = tomography=20 (PET) and single-photon-emission CT (SPECT), as well as = dose-volume=20 histograms allow physicians to more accurately plan target = volumes=20 and shape radiation beams [63].=20 With these technical improvements, it is hoped that RT will = be more=20 effective and long-term side effects of RT will be = minimized.=20

Although stereotactic radiosurgery has been proposed to control=20 small areas of recurrent malignant glioma, there are = insufficient=20 data to recommend radiosurgery as an effective treatment for=20 LGG.

At this time, it is our practice to defer RT after complete=20 surgical resection of an LGG with a low mitotic labeling = index.=20 In the case of incomplete resection, RT is recommended if = there=20 is an elevated mitotic labeling index or recurrence of tumor = on=20 follow-up imaging.

Chemotherapy
Most chemotherapeutic agents that = are active=20 against anaplastic glioma also have activity against LGG. A = major=20 advance relevant to the chemotherapeutic treatment for LGG = was the=20 discovery of the chemosensitivity of anaplastic = oligodendroglioma=20 based on chromosomal markers. Cairncross et al. [35]=20 observed that 100% of tumors with chromosome 1p loss (24 = patients)=20 were chemosensitive and that 100% of those with loss of both = 1p and=20 19q (22 patients) also responded to chemotherapy. The = patients with=20 the chromosomal losses also had significantly longer = progression-free=20 and overall survival times.

Several phase II studies have investigated the role of = chemotherapy=20 or the combination of chemotherapy and RT in LGG. One problem = with assessing tumor response in these studies is that change = in area-of-contrast enhancement has traditionally been used=20 with studies of higher-grade glioma, yet as discussed = earlier,=20 LGGs do not typically enhance, thus complicating the = measurement=20 of response to chemotherapy [64].=20 FLAIR and T2 signal changes often reflect the combined effect = of=20 underlying tumor and gliosis, making response assessment more = difficult.

Nine patients with LGO were treated with PCV (procarbazine, = CCNU,=20 vincristine) at presentation, except for one patient who was = treated=20 at the time of recurrence after failed RT [65].=20 Evaluation of response was based on clinical and radiological = factors, including volumetric tumor measurements on = T2-weighted=20 MRI scans. Six patients had partial responses and three had=20 stable disease, while no patient deteriorated during = treatment.=20 There were also notable improvements in seizure frequency and = other neurologic symptoms [65].=20

A retrospective study by Stege et al. [66]=20 of PCV chemotherapy in 16 patients with newly diagnosed LGO = and LGOA=20 along with five patients with recurrent disease showed = "clinical"=20 response regardless of 1p or 19q status. Nine of these = patients had=20 gliomatosis cerebri. These authors recommended chemotherapy = for LGO=20 patients with large tumors not amenable to RT.

Several studies have addressed the use of temozolomide in the=20 treatment of recurrent or progressive LGG [38,=20 67=9670].=20 Temozolomide is approved for the treatment of recurrent = anaplastic=20 astrocytoma and newly diagnosed glioblastoma. Phase II = studies=20 have provided evidence of excellent patient tolerance and = potential=20 efficacy in LGG, but comparison studies versus other = chemotherapeutic=20 agents or RT have not been done. In a phase II study by Brada = et al. [69],=20 temozolomide resulted in a modest improvement in QoL and = improvement=20 in seizure control.

Another issue in the treatment of patients with LGG is whether = a=20 combination of chemotherapy and RT is superior to RT alone = [71].=20 A prospective trial by the Southwest Oncology Group addressed = this=20 question in 60 adult patients with incompletely resected = LGGs.=20 Patients were randomly divided into two treatment groups. = Patients=20 received either 55 Gy of RT alone or 55 Gy of RT-plus-lomustine.=20 There was a reduction in tumor size in 79% of patients in the = RT group versus 54% of the RT plus lomustine group, based on = CT=20 scan measurements. However, there was no difference in median=20 survival between the two treatment groups [72].=20 This study did not separate different histologic subtypes for = analysis, and anaplastic astrocytoma was included as an = eligible=20 tumor, which complicates interpretation of the results. The = study was=20 closed early because of slow accrual and a rejection of the=20 hypothesis of a 50% longer survival time for patients = receiving=20 chemotherapy [72].=20

Newer agents, such as signal transduction inhibitors, = angiogenesis=20 inhibitors, monoclonal antibodies, immunotoxins, and gene = transfer=20 therapies, as well as new approaches to drug delivery, such = as=20 drug-impregnated sustained-release polymers and convection-enhanced = delivery, remain to be investigated in LGGs.


3D"    PROGNOSIS IN=20 LOW-GRADE GLIOMAS
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
3D"Prognosis in Low-Grade = Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
T= he=20 prognosis for patients with LGG is more favorable than that = for=20 higher-grade gliomas because of the more indolent course and = younger=20 age at which most patients are diagnosed. The three largest=20 randomized trials mentioned previously all included overall = survival=20 as a primary end point. EORTC 22844, EORTC 22845, and the = NCCTG trial=20 together studied 836 patients with LGG, and 58%=9672% of = patients were=20 alive at 5 years from the time of diagnosis. The EORTC = conducted a=20 detailed analysis of prognostic factors for overall survival = based on=20 the 22844 and 22845 studies. That analysis excluded patients = with=20 WHO grade 1 astrocytomas and was conducted over a longer=20 follow-up than either of the two original studies. Factors = that=20 negatively affected survival were: age >40 years, = astrocytoma=20 histology, maximum tumor diameter 3D≥=206 = cm, tumor=20 crossing the corpus callosum, and the presence of a = neurological=20 deficit before surgery. Based on these factors, the EORTC = proposed a=20 multivariate prognostic score that would separate patients = into risk=20 categories. Patients with two or fewer prognostic factors = were deemed=20 low risk, and their median overall survival time was 7.7 = years.=20 Patients with three or more prognostic factors were judged to = be high=20 risk, and their median overall survival time was 3.2 years = [73].=20 The NCCTG identified tumor size, histologic subtype, and age = as=20 substantial prognostic factors in their group of patients. = The=20 median survival time for their entire cohort of 203 patients=20 was 9.25 years [61].=20


3D"    SPECIAL TOPICS=20
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
3D"Special = Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
References
 
<= STRONG>Pilocytic=20 Astrocytomas
Pilocytic astrocytomas (PAs) are = well-circumscribed=20 solid tumors that occur most frequently in children and young = adults=20 but rarely in those over the age of 30 years (Fig. 3). These tumors have also been = termed juvenile=20 pilocytic astrocytomas or cystic astrocytomas, or have been = named=20 according to location (e.g., optic nerve gliomas, cerebellar=20 astrocytomas, etc.). PAs represent 1.9% of all reported brain = tumors=20 and 5.7% of all gliomas [1].=20 PAs may also be associated with neurofibromatosis-1 (NF-1), = an=20 autosomal dominant genetic disorder in which patients are at = high=20 risk for cranial and peripheral nerve sheath tumors. The mean = age at=20 diagnosis of PA is 17 years, and the survival rate is very = good, with=20 84.3% of patients alive 10 years after diagnosis [1].=20 Supratentorial PAs are characteristically located in the = region of=20 the optic nerves or chiasm as well as in periventricular = regions such=20 as the hypothalamus and thalamus. PAs may also occur in the = spinal=20 cord either as a primary site or as a site of metastatic = spread.=20



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  		Figure 3. Juvenile = pilocytic=20 astrocytoma. Axial (A, B) and sagittal (C) = T1-weighted=20 images before and after gadolinium administration show a=20 well-circumscribed mass lesion with irregular ring = enhancement in=20 the left cerebellar hemisphere. Thin, smooth enhancement of = the=20 margins of the cystic structures is seen (arrow). Courtesy = of John=20 W. Henson, M.D., Department of Radiology, Massachusetts = General=20 Hospital. =

 = ;
Although=20 macroscopically PAs appear well demarcated, these tumors may=20 infiltrate surrounding tissue on the microscopic level. = Microscopic=20 infiltration is seen in adult forms of PA but is rarely seen = in=20 juvenile PA [74].=20 Multicentric spread is well documented, and patients with=20 hypothalamic region tumors are up to 23 times more likely to = develop=20 multicentric spread than those with PAs elsewhere [75].=20 One third of tumors form a large cyst with clear fluid and = sometimes=20 a mural nodule [76].=20 PAs frequently enhance on MRI because of their vascularity, = but=20 there is usually minimal associated edema. Malignant = transformation=20 and metastatic spread are rare.

Clinical Features
Most patients present = within=20 the first three decades of life. Because PAs have a tendency = to=20 develop in midline peri-ventricular zones, patients may = present with=20 evidence of obstructive hydrocephalus. If the tumor occurs in = an=20 infratentorial location, the patient may present with = symptoms of=20 increased intracranial pressure or cerebellar dysfunction.=20 Association with NF-1 should be excluded in all cases. = Seizures,=20 headaches, cranial nerve deficits, and rarely, hemorrhage, = may also=20 be part of the patient=92s initial clinical = presentation.

Treatment
The majority of PAs are = amenable to=20 gross total resection and cure. The best predictor of outcome = is=20 extent of resection, with >90% 10-year survival rates in = patients=20 with gross total resection of cerebellar PAs. Chemotherapy or = RT may=20 be recommended if there is residual tumor after resection. = Focal=20 irradiation at a total dose of 54=9656 Gy is recommended in = adults=20 and children over the age of 5 years [75].=20 In patients with subtotally resected PAs, the incidence of = recurrence=20 in a site different from the primary site is approximately = 12% [75].=20 MRI of the craniospinal axis and cerebrospinal fluid (CSF)=20 examination should be routinely performed in patients with = PAs.=20

Subependymal Giant Cell Astrocytoma
Subependymal = giant=20 cell astrocytomas (SGCAs) are almost always associated with = tuberous=20 sclerosis. Tuberous sclerosis is an autosomal dominant = neurocutaneous=20 disorder characterized by mental retardation, seizures, = facial=20 angiofibromas and SGCAs. SGCAs are firm, slow-growing,=20 well-circumscribed tumors typically located in the walls of = the=20 lateral ventricles near the foramen of Monro (Fig. 4). There may be associated cyst formation, = hemorrhage,=20 necrosis, or calcification. On MR images, the tumors usually=20 appear as intraventricular enhancing masses. On histological=20 examination, the tumors consist of giant astrocytes without=20 significant anaplasia.



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  		Figure 4. Subependymal = giant cell=20 astrocytoma. This axial, postcontrast, fat-saturated = T1-weighted=20 image shows the tumor as an enhancing, mass lesion at the = foramen of=20 Monro (arrow). Progressive enlargement may be the only way = to=20 distinguish the tumor from subependymal nodules seen in = tuberous=20 sclerosis. Courtesy of John W. Henson, M.D., Department of=20 Radiology, Massachusetts General Hospital. =

 = ;

Clinical Symptoms
Because these tumors = typically=20 obstruct CSF flow, patients usually become symptomatic with=20 hydrocephalus or increased intracranial pressure during the = first and=20 second decades of life. Diagnosis of an SGCA is occasionally = the=20 presenting feature of tuberous sclerosis.

Treatment
Treatment for SGCA depends = upon=20 symptoms. Surgical resection is performed if symptoms are = severe and=20 resection is possible based on location. These tumors rarely = display=20 malignant degeneration. Fatal cases are usually secondary to = surgical=20 complications. The favorable prognosis distinguishes SGCAs = from other=20 intraventricular tumors, such as intraventricular ependymomas = and=20 astrocytomas, which typically have worse prognoses. =

Brainstem Gliomas
Approximately 4% of all gliomas = occur=20 in the brainstem [1].=20 Brainstem gliomas tend to affect children and young adults = and=20 comprise a heterogeneous group of neoplasms. Brainstem = gliomas=20 have the worst prognosis of any childhood brain tumor, but = subsets=20 of brainstem gliomas=97including NF-1-associated gliomas, = tectal=20 gliomas, and cervicomedullary gliomas=97have better prognoses = [77,=20 78].=20 Approximately 4% of patients with NF-1 have brainstem = astrocytomas=20 [79].=20 In contrast to other patients, NF-1-associated tumors are = usually=20 centered in the medulla, not in the pons [79].=20 Brainstem gliomas are diffusely infiltrative tumors and, in = some=20 instances, may display malignant transformation [80].=20 These tumors may also have a cystic component, which has not = been=20 shown to affect survival [80].=20

Clinical Features
Because of the = indolent nature=20 of these tumors, symptoms may be vague and include failure to = thrive,=20 persistent vomiting, and abnormal breathing. Patients with = NF-1=20 appear to have a higher rate of hydrocephalus requiring early = intervention [79].=20 Cervicomedullary tumors may cause symptoms ranging from a = mild=20 motor deficit to quadriparesis with varying involvement of = cranial=20 nerves, and some patients may become tracheostomy dependent = or=20 require ventilation. Although tumor infiltration along cranial = nerves=20 is rare, it has been described without evidence of leptomeningeal=20 dissemination [81].=20 With pontine gliomas, symptom duration is relatively short, = 2=964=20 months, whereas the duration of symptoms before diagnosis of = patients=20 with cervicomedullary gliomas may range up to 2 years because = of the=20 indolent nature of these typically lower-grade lesions [82].=20 Other clinical features seen in patients with brainstem = gliomas=20 include headache, gross motor incoordination, head tilt, and=20 developmental delay.

Treatment
For most brainstem gliomas, = total=20 resection is not possible. Accurate histopathological = diagnosis is=20 often difficult because obtaining tumor tissue can be risky = and is=20 limited by sampling error. Cystic tumors may be aspirated and = tumor=20 volume debulked for palliative reasons [80].=20 In a series of patients with cervicomedullary gliomas, = Robertson et=20 al. [82]=20 confirmed that these tumors were distinct, with generally = indolent=20 courses and low-grade pathology. Four-year progression-free = and=20 overall survival rates are as high as 70% and 100%,=20 respectively.

The role of RT is controversial, and some authorities advocate=20 chemotherapy in place of RT, especially in young patients or=20 patients who have received prior radiation [83].=20 Broniscer et al. [84]=20 found that administration of temozolomide after RT in = children with=20 newly diagnosed diffuse brainstem gliomas did not alter the = poor=20 prognosis. All patients in their study died within a median = of 12=20 months.

Because NF-1-associated brainstem gliomas are less aggressive = than=20 their non-NF-1 counterparts, Molloy et al. [79]=20 recommend conservative management, including close clinical=20 observation and radiographic follow-up.

Optic Nerve Gliomas
Optic nerve gliomas are = generally=20 considered to be low-grade astrocytomas with occasional=20 oligodendrocytic components, but these tumors may display a = wide=20 variation in growth rate and clinical behavior [85].=20 Optic nerve gliomas are most commonly found in children with = NF-1,=20 and only rarely in adults. When optic nerve gliomas present = in=20 adulthood, the tumors are usually bilateral and malignant, = and may=20 mimic optic neuritis in initial presentation [86].=20

Optic nerve gliomas typically involve the hypothalamus and optic = chiasm more frequently than the intraorbital optic nerve [85]=20 (Fig. 5). Tumors involving the hypothalamus may be = considered=20 as a separate subset of optic pathway gliomas in terms of = management=20 and prognosis. Histology is typically low-grade astrocytoma=20 with a higher frequency of malignant variants seen in older=20 patients and in patients with tumors located near the optic=20 chiasm. Among children who are long-term survivors of CNS = tumors,=20 cases of optic glioma have developed in later years as = secondary=20 tumors [87].=20 In patients with NF-1, these tumors most commonly occur in = the=20 optic=96hypothalamic region [83].=20



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  		Figure 5. Optic nerve = glioma.=20 (A): T1-weighted, gadolinium-enhanced, fat-saturated = image=20 reveals enlargement and abnormal enhancement of the orbital=20 component of the right optic nerve (white arrow) and of the = optic=20 chiasm (black arrow). (B): T2-weighted image shows = the=20 enlarged right optic nerve compared to the normal left optic = nerve.=20 Courtesy of John W. Henson, M.D., Department of Radiology,=20 Massachusetts General Hospital. =

 = ;

Clinical Features
Visual loss, endocrine = disturbances, and proptosis may be the initial complaints [85]=20 When tumors are located in the optic chiasm=96hypothalamic = region, the=20 majority of patients present with signs of increased = intracranial=20 pressure and may require CSF shunting [83].=20 In adults, optic nerve gliomas can mimic optic neuritis in = their=20 clinical presentation [86].=20

Treatment
Location and patient age = determine=20 optimum treatment. Surgery is generally recommended for = tumors of the=20 optic nerve, and RT is recommended for tumors of the optic = chiasm [85].=20 Optic chiasmal gliomas appear to respond to radiation with = doses=20 above 45 Gy [85].=20 An estimated 25% of optic nerve gliomas have already invaded = the=20 optic chiasm by the time of diagnosis, and another 5% recur = in the=20 chiasm following a complete intraorbital resection [85].=20 Patients with NF-1 have twice the rate of recurrence, but = their=20 prognosis does not differ from other patients after = irradiation of=20 chiasmal gliomas [85].=20 In adults, although RT appears to prolong life expectancy, = neither=20 surgery, RT, nor chemotherapy has been able to prevent visual = loss=20 and death for most patients within 12=9624 months of = diagnosis [86].=20


3D"    TREATMENT-RELATED COMPLICATIONS
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
3D"Treatment-Related = Complications
Conclusion
Disclosure of Potential...
References
 
I= n=20 addition to the symptoms caused directly by the brain tumor, = patients=20 with LGGs often experience significant adverse effects from = various=20 treatment modalities administered for the tumor. This is an = important=20 issue to consider when contemplating treatment of a patient = with LGG=20 because this population is generally young and these tumors = are slow=20 growing and may not even be causing symptoms at the time of=20 diagnosis. RT may have neurotoxic effects and can produce=20 neurological and cognitive symptoms. Because RT is often = included in=20 the treatment of patients with LGG, there is concern about = possible=20 adverse effects in this population. Because of the long = survival=20 times of these patients and the concern regarding RT effects, = both=20 the EORTC and the NCCTG have conducted studies to address = this issue.=20 In 1985, when the EORTC Radiotherapy Cooperative Group began = the=20 phase III trial on dose response of LGG to RT, a QoL = questionnaire=20 was also included to assess physical, social, sexual, = cognitive, and=20 emotional factors overtime. In this QoL portion of EORTC = 22844, 379=20 patients were randomized to receive either high-dose (59.4 = Gy) or=20 low-dose (45 Gy) RT, and 22%=9643% of these patients = completed and=20 returned the QoL forms [88].=20 Analysis of responses suggested that patients who received = high-dose=20 RT had lower levels of daily functioning and more negative = symptoms=20 in the first 6 months after RT [88].=20 Emotional health and quality of leisure time were = significantly=20 different between the high-dose and lower-dose RT groups even = 7=9615=20 months after radiotherapy [88].=20

The NCCTG likewise analyzed cognitive performance data using = the=20 Folstein Mini-Mental State Examination (MMSE) and neurologic = function=20 score (NFS), collected in a prospective clinical trial of 203 = patients. NFS was calculated based on the number of neurological=20 symptoms the patient experienced as well as functional = status.=20 The investigators found that after focal RT, most patients = with=20 LGG had a stable neurocognitive status, and if a change was=20 noted, it was more often an improvement in status following = RT=20 treatment [89].=20 In that study, patients received either a total RT dose of = 50.4 Gy in=20 28 fractions or a higher total dose of 64.8 Gy [88].=20 A fundamental weakness of the study was the lack of a more=20 discriminating neurocognitive assessment tool. Although the = MMSE is=20 easy for clinicians to use and may be sufficient for = assessing=20 dementia, it relies mainly on verbal skills and is not = sufficiently=20 sensitive to detect subtle intellectual changes that may = occur in=20 young, otherwise healthy LGG patients.

Klein et al. [90]=20 compared cognitive function in a group of 195 patients with = LGG, of=20 whom, over half had received prior RT. The comparison groups=20 consisted of patients with hematological disease and a group = of=20 healthy controls. Results from a comprehensive battery of=20 neuropsychological tests suggested that it was the tumor = itself that=20 had the greatest deleterious effect on cognitive health, as = both=20 irradiated and nonirradiated LGG patients had significantly = worse=20 scores than either of the other two groups. Their results = agreed with=20 previous studies that the radiation dose, treatment volume, = and size=20 of fraction are responsible for the late neurotoxicity = associated=20 with RT. Their study did not include pretreatment tests of = cognition.=20 This is a shortcoming of most studies and complicates the=20 determination of how much cognitive decline is a result of = the tumor=20 itself, versus an iatrogenic cause.

Antiepileptic drugs and chemotherapeutic agents are also capable = of deleterious effects on cognitive functioning as well as on = the emotional and physical health of LGG patients. Other = agents=20 that may affect QoL include corticosteroids and = anticoagulants=20 used to treat other major medical problems accompanying brain = tumors.

Although treatment-related secondary malignancies have been = the=20 subject of much debate in childhood cancer patients as well = as=20 non-Hodgkin=92s lymphoma patients [87,=20 91=9693],=20 the advances in treatment strategies make this a new area of=20 concern in the glioma population. There is compelling = evidence=20 that alkylating agents can cause chromosomal damage that may=20 lead to secondary malignancies, including treatment-related=20 myelodysplastic syndrome (tMDS), acute myelogenous leukemia, = or=20 bone sarcoma in later years [87,=20 92,=20 94].=20

Temozolomide and procarbazine, two drugs commonly used in = patients=20 with malignant gliomas, exert their anticancer activity = through=20 the methylation of DNA at the O6 position of guanine=20 residues [95,=20 96].=20 Prolonged administration of temozolomide is associated with = side=20 effects, including prolonged lymphopenia even after drug=20 discontinuation and susceptibility to clinically significant=20 opportunistic infections including Pneumocystis carinii=20 pneumonia, herpes simplex virus, and Kaposi=92s sarcoma [97].=20 There is one published report and other clinical reports of = tMDS=20 after temozolomide treatment [98].=20 The prognosis of tMDS is generally poor, with rapid evolution = into=20 acute leukemia. Ongoing studies of prolonged temozolomide = schedules=20 should monitor for and report second malignancies so this = issue can=20 be further clarified [95].=20


3D"    CONCLUSION
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
3D"Conclusion
Disclosure of Potential...
References
 
L= GGs are a=20 heterogeneous group of CNS neoplasms that pose unique = management=20 challenges. The tumors typically occur in younger, healthier = patient=20 populations, and life expectancy is often a decade or more. = Thus,=20 both the short-term and long-term risks of therapy must be = carefully=20 weighed in this patient population. There have been no = randomized=20 trials of resection versus biopsy or observation. However,=20 retrospective data suggest that maximal surgical resection = does=20 provide a survival benefit for patients with LGGs. RT does = prolong=20 progression-free survival but not overall survival, as = demonstrated=20 in three randomized trials. Although significant cognitive = decline=20 over time has not been reported in these prospective RT = trials, the=20 assessment tools for such detection are insensitive. = Chemotherapy may=20 be associated with a reduction in tumor size in LGG subsets,=20 including those tumors with oligodendroglial elements or = those tumors=20 with loss of chromosome 1p. LOH for chromosome 1p does seem = to=20 correlate with a better prognosis in LGOs. Future = developments of=20 importance for patients with LGGs will include better = intraoperative=20 mapping and imaging to allow for more aggressive resections; = the=20 development of safer radiation techniques that will "spare" = adjacent=20 normal brain tissue; incorporation of molecular markers of=20 prognosis, especially for LGOs; and the development of=20 chemotherapeutic strategies for chemosensitive LGGs. Future = trials=20 need more sensitive measures of long-term cognitive, = functional, and=20 QoL outcomes.


3D"    DISCLOSURE OF=20 POTENTIAL CONFLICTS OF INTEREST=20
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
3D"Disclosure of = Potential...
References
 
T= he=20 authors indicate no potential conflicts of interest.


3D"    REFERENCES
Top
Learning Objectives
Abstract
Introduction
Incidence
Presentation
Diagnosis
Treatment
Prognosis in Low-Grade Gliomas
Special Topics
Treatment-Related Complications
Conclusion
Disclosure of Potential...
3D"References
&nb= sp;

  1. Central Brain Tumor Registry of the United States. = Statistical=20 Report: Primary Brain Tumors in the United States, 1997=962001. = Chicago: CBTRUS,=20 2004:1=9651.
  2. Fritz AG, Percy C, Jack A et al., eds. International=20 Classification of Diseases for Oncology, 3rd Ed. T.E. Geneva, = Switzerland:=20 World Health Organization, 2000:1=96240.
  3. Shaw E, Bernstein M, Recht L et al. Practice parameters = in adults=20 with suspected or known supratentorial nonoptic pathway low-grade = glioma.=20 Neurosurg Focus=20 1998;4:10.
  4. Schlehofer B, Hettinger I, Ryan P et al. Occupational = risk factors=20 for low grade and high grade glioma: results from an international = case=20 control study of adult brain tumours. Int J Cancer = 2005;113:116=96125.[CrossRef][Medline]
  5. Whittle IR. The dilemma of low-grade glioma. J Neurol = Neurosurg=20 Psychiatry 2004;75(suppl 2):ii31=96ii36.[Free Full Text]
  6. Yeh SA, Lee TC, Chen HJ et al. Treatment outcomes and = prognostic=20 factors of patients with supratentorial low-grade oligodendroglioma. = Int J=20 Radiat Oncol Biol Phys 2002;54:1405=961409.[CrossRef][Medline]
  7. Recht LD, Lew R, Smith TW. Suspected low-grade glioma: = is=20 deferring treatment safe? Ann Neurol 1992;31:431=96436.[CrossRef][Medline]
  8. Shafqat S, Hedley-Whyte ET, Henson JW. Age-dependent = rate of=20 anaplastic transformation in low-grade astrocytoma. Neurology 1999;52: = 867=96869.[Abstract/Free Full Text]
  9. Shaw EG, Scheithauer BW, O=92Fallon JR et al. Mixed=20 oligoastrocytomas: a survival and prognostic factor analysis. = Neurosurgery=20 1994;34:577=96582; discussion 582.[Medline]
  10. Wessels PH, Weber WE, Raven G et al. Supratentorial = grade II=20 astrocytoma: biological features and clinical course. Lancet Neurol = 2003;2:=20 395=96403.[CrossRef][Medline]
  11. Olson JD, Riedel E, DeAngelis LM. Long-term outcome of = low-grade=20 oligodendroglioma and mixed glioma. Neurology 2000;54:1442=961448.[Abstract/Free Full Text]
  12. Lebrun C, Fontaine D, Ramaioli A et al. Long-term = outcome of=20 oligodengrogliomas. Neurology 2004;62:1783=961787.[Abstract/Free Full Text]
  13. Pirzkall A, Nelson SJ, McKnight TR et al. Metabolic = imaging of=20 low-grade gliomas with three-dimensional magnetic resonance = spectroscopy. Int=20 J Radiat Oncol Biol Phys=20 2002;53:1254=961264.[CrossRef][Medline]
  14. Henson JW, Gaviani P, Gonzalez RG. MRI in treatment of = adult=20 gliomas. Lancet Oncol 2005;6:167=96175.[CrossRef][Medline]
  15. Recht LD, Bernstein M. Low-grade gliomas. Neurol Clin = 1995;13:=20 847=96859.[Medline]
  16. McKnight TR, von dem Bussche MH, Vigneron DB et al.=20 Histopathological validation of a three-dimensional magnetic resonance = spectroscopy index as a predictor of tumor presence. J Neurosurg=20 2002;97:794=96802.[Medline]
  17. Nuutinen J, Sonninen P, Lehikoinen P et al. = Radiotherapy=20 treatment planning and long-term follow-up with [(11)C]methionine PET = in=20 patients with low-grade astrocytoma. Int J Radiat Oncol Biol Phys = 2000;48:=20 43=9652.[CrossRef][Medline]
  18. Galanaud D, Chinot O, Nicoli F et al. Use of proton = magnetic=20 resonance spectroscopy of the brain to differentiate gliomatosis = cerebri from=20 low-grade glioma. J Neurosurg 2003;98:269=96276.[Medline]
  19. Pirotte B, Goldman S, Massager N et al. Combined use of = 18F-fluorode-oxyglucose and 11C-methionine in 45 positron emission=20 tomography-guided stereotactic brain biopsies. J Neurosurg = 2004;101:476=96483.[Medline]
  20. Lopes MB, Laws ER. Low-grade central nervous system = tumors.=20 Neurol Focus=20 2002;12:1=964.
  21. Afra D, MW. Recurrent low-grade gliomas: = dedifferentiation and=20 prospects of reoperation. In: Karim ABMF, Karim ER, eds. GLIOMA: = Principles=20 and Practice in Neuro-Oncology. Berlin-Heidelberg, Germany: = Springer-Verlag,=20 1991:189=96203.
  22. Cha S, Tihan T, Crawford F et al. Differentiation of = low-grade=20 oligodendrogliomas from low-grade astrocytomas by using quantitative=20 blood-volume measurements derived from dynamic susceptibility=20 contrast-enhanced MR imaging. AJNR Am J Neuroradiol = 2005;26:266=96273.[Abstract/Free Full Text]
  23. Jeuken JW, von Deimling A, Wesseling P. Molecular = pathogenesis of=20 oligodendroglial tumors. J Neurooncol 2004;70:161=96181.[CrossRef][Medline]
  24. Smith JS, Perry A, Borell TJ et al. Alterations of = chromosome=20 arms 1p and 19q as predictors of survival in oligodendrogliomas, = astrocytomas,=20 and mixed oligoastrocytomas. J Clin Oncol 2000;18:636=96645.[Abstract/Free Full Text]
  25. Eskandar EN, Loeffler JS, O=92Neill AM et al. Case = records of the=20 Massachusetts General Hospital. Weekly clinicopathological exercises. = Case=20 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain = lesion. N=20 Engl J Med 2004;351:1875=961882.[Free Full Text]
  26. Lunsford LD, Somaza S, Kondziolka D et al. Survival = after=20 stereotactic biopsy and irradiation of cerebral nonanaplastic, = nonpilocytic=20 astrocytoma. J Neurosurg 1995;82:523=96529.[Medline]
  27. Revesz T, Scaravilli F, Coutinho L et al. Reliability = of=20 histological diagnosis including grading in gliomas biopsied by = image-guided=20 stereotactic technique. Brain 1993;116:781=96793.[Abstract/Free Full Text]
  28. Muller W, Afra D, Schroder R. Supratentorial = recurrences of=20 gliomas. Morphological studies in relation to time intervals with=20 astrocytomas. Acta Neurochir (Wien) 1977;37:75=9691.[CrossRef][Medline]
  29. Chandrasoma PT, Smith MM, Apuzzo ML. Stereotactic = biopsy in the=20 diagnosis of brain masses: comparison of results of biopsy and = resected=20 surgical specimen. Neurosurgery 1989;24:160=96165.[Medline]
  30. Maia AC, Malheiros SM, da Rocha AJ et al. Stereotactic = biopsy=20 guidance in adults with supratentorial nonenhancing gliomas: role of=20 perfusion-weighted magnetic resonance imaging. J Neurosurg = 2004;101:970=96976.[Medline]
  31. Hakyemez B, Erdogan C, Ercan I et al. High-grade and = low-grade=20 gliomas: differentiation by using perfusion MR imaging. Clin Radiol=20 2005;60:493=96502.[CrossRef][Medline]
  32. Daumas-Duport C, Scheithauer B, O=92Fallon J et al. = Grading of=20 astrocytomas. A simple and reproducible method. Cancer = 1988;62:2152=962165.[Medline]
  33. Reifenberger J, Reifenberger G, Liu L et al. Molecular = genetic=20 analysis of oligodendroglial tumors shows preferential allelic = deletions on=20 19q and 1p. Am J Pathol=20 1994;145:1175=961190.[Abstract]
  34. von Deimling A, Louis DN, von Ammon K et al. Evidence = for a tumor=20 suppressor gene on chromosome 19q associated with human astrocytomas,=20 oligodendrogliomas, and mixed gliomas. Cancer Res = 1992;52:4227=964279.[Abstract]
  35. Cairncross JG, Ueki K, Zlatescu MC et al. Specific = genetic=20 predictors of chemotherapeutic response and survival in patients with=20 anaplastic oligodendrogliomas. J Natl Cancer Inst = 1998;90:1473=961479.[Abstract/Free Full Text]
  36. Buckner JC, Ballman KV, Scheithauer BW et al. = Diagnostic and=20 prognostic significance of 1p and 19q deletions in patients with = low-grade=20 oligodendroglioma and astrocytoma. Proc Am Soc Clin Oncol = 2005;23:114S.
  37. Ashby LS, Pueschel JK, Scheck AC et al. Prognostic = factors for=20 patients with newly diagnosed low-grade oligodendroglial tumors: = molecular=20 genetics, histopathology, and neuroimaging. Proc Am Soc Clin Oncol=20 2005;23:114S.
  38. Hoang-Xuan K, Capelle L, Kujas M et al. Temozolomide as = initial=20 treatment for adults with low-grade oligodendrogliomas or = oligoastrocytomas=20 and correlation with chromosome 1p deletions. J Clin Oncol = 2004;22:3133=963138.[Abstract/Free Full Text]
  39. DeGirolami U, Smith TW. Neuropathology of central = nervous system=20 tumors. In: Black PM, Loeffler JS, eds. Cancer of the Nervous System, = Second=20 Edition. Philadelphia: Lippincott, Williams & Wilkins: = 2005:18;15=9645.
  40. Kros JM, Hop WC, Godschalk JJ et al. Prognostic value = of the=20 proliferation-related antigen Ki-67 in oligodendrogliomas. Cancer = 1996;78:=20 1107=961113.3.0.CO;2-5&= ;link_type=3DDOI">[CrossRef][Medline]
  41. Burger PC, Scheithauer B, Vogel FS. Surgical Pathology = of the=20 Nervous System and Its Coverings, Fourth Edition. New York: Churchill=20 Livingstone, 2002:1=96657.
  42. Schiffer D, Dutto A, Cavalla P et al. Prognostic = factors in=20 oligodendroglioma. Can J Neurol Sci 1997;24:313=96319.[Medline]
  43. Coons SW, Johnson PC, Pearl DK. The prognostic = significance of=20 Ki-67 labeling indices for oligodendrogliomas. Neurosurgery = 1997;41:878=96884;=20 discussion 884=96885.[CrossRef]<= A=20 = href=3D"http://theoncologist.alphamedpress.org/cgi/external_ref?access_nu= m=3D9316050&link_type=3DMED">[Medline]
  44. Cairncross JG, Laperriere NJ. Low-grade glioma. To = treat or not=20 to treat? Arch Neurol 1989;46:1238=961239.[CrossRef][Medline]
  45. Mandonnet E, Delattre JY, Tanguy ML et al. Continuous = growth of=20 mean tumor diameter in a subset of grade II gliomas. Ann Neurol=20 2003;53:524=96528.[CrossRef][Medline]
  46. Ashby LS, Shapiro WR. Low-grade glioma: supratentorial=20 astrocytoma, oligodendroglioma, and oligoastrocytoma in adults. Curr = Neurol=20 Neurosci Rep 2004;4:211=96217.[Medline]
  47. Keles GE, Lamborn KR, Berger MS. Low-grade hemispheric = gliomas in=20 adults: a critical review of extent of resection as a factor = influencing=20 outcome. J Neurosurg 2001;95:735=96745.[Medline]
  48. Berger MS, Deliganis AV, Dobbins J et al. The effect of = extent of=20 resection on recurrence in patients with low grade cerebral hemisphere = gliomas. Cancer 1994;74:1784=961791.[Medline]
  49. van Veelen ML, Avezaat CJ, Kros JM et al. = Supratentorial low=20 grade astrocytoma: prognostic factors, dedifferentiation, and the = issue of=20 early versus late surgery. J Neurol Neurosurg Psychiatry = 1998;64:581=96587.[Abstract/Free Full Text]
  50. Leighton C, Fisher B, Bauman G et al. Supratentorial = low-grade=20 glioma in adults: an analysis of prognostic factors and timing of = radiation. J=20 Clin Oncol 1997;15:1294=961301.[Abstract/Free Full Text]
  51. Packer RJ, Mehta M. Neurocognitive sequelae of cancer = treatment.=20 Neurology 2002;59:8=9610.[Free Full Text]
  52. Surma-aho O, Niemela M, Vilkki J et al. Adverse = long-term effects=20 of brain radiotherapy in adult low-grade glioma patients. Neurology=20 2001;56:1285=961290.[Abstract/Free Full Text]
  53. Fazekas JT. Treatment of grades I and II brain = astrocytomas. The=20 role of radiotherapy. Int J Radiat Oncol Biol Phys = 1977;2:661=96666.[Medline]
  54. Higuchi Y, Iwadate Y, Yamaura A. Treatment of low-grade = oligodendroglial tumors without radiotherapy. Neurology = 2004;63:2384=962386.[Abstract/Free Full Text]
  55. Garcia DM, Fulling KH, Marks JE. The value of radiation = therapy=20 in addition to surgery for astrocytomas of the adult cerebrum. Cancer=20 1985;55:919=96927.[Medline]
  56. Schultheiss TE, Kun LE, Ang KK et al. Radiation = response of the=20 central nervous system. Int J Radiat Oncol Biol Phys = 1995;31:1093=961112.[CrossRef][Medline]
  57. Karim A. Cure and quality of life after treatment for = glioma. In:=20 Karim ABMF, Laws ER, eds. GLIOMA: Principles and Practice in = Neuro-Oncology.=20 Berlin: Springer-Verlag, 1991:1=96289.
  58. Karim AB, Maat B, Hatlevoll R et al. A randomized trial = on=20 dose-response in radiation therapy of low-grade cerebral glioma: = European=20 Organization for Research and Treatment of Cancer (EORTC) Study 22844. = Int J=20 Radiat Oncol Biol Phys 1996;36:549=96556.[CrossRef][Medline]
  59. Karim AB, Afra D, Cornu P et al. Randomized trial on = the efficacy=20 of radiotherapy for cerebral low-grade glioma in the adult: European=20 Organization for Research and Treatment of Cancer Study 22845 with the = Medical=20 Research Council study BRO4: an interim analysis. Int J Radiat Oncol = Biol Phys=20 2002;52:316=96324.[CrossRef][Medline]
  60. van den Bent MJ, Afra D, de WitteO et al. Long-term = efficacy of=20 early versus delayed radiotherapy for low-grade astrocytoma and=20 oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet=20 2005;366:985=96990.[CrossRef][Medline]
  61. Shaw E, Arusell R, Scheithauer B et al. Prospective = randomized=20 trial of low- versus high-dose radiation therapy in adults with = supratentorial=20 low-grade glioma: initial report of a North Central Cancer Treatment=20 Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology = Group=20 study. J Clin Oncol 2002;20:2267=962276.[Abstract/Free Full Text]
  62. Shaw EG, Wisoff JH. Prospective clinical trials of = intracranial=20 low-grade glioma in adults and children. Neurooncol = 2003;5:153=96160.[Abstract/Free Full Text]
  63. Moran JM, Elshaikh MA, Lawrence TS. Radiotherapy: what = can be=20 achieved by technical improvements in dose delivery? Lancet Oncol=20 2005;6):51=9658.[Medline]
  64. Van den Bent MJ. Can chemotherapy replace radiotherapy = in=20 low-grade gliomas? Time for randomized studies. Semin Oncol = 2003;30(suppl=20 19):39=9644.[Medline]
  65. Mason WP, Krol GS, DeAngelis LM. Low-grade = oligodendroglioma=20 responds to chemotherapy. Neurology 1996;46:203=96207.[Abstract]
  66. Stege EM, Kros JM, de Bruin HG et al. Successful = treatment of=20 low-grade oligodendroglial tumors with a chemotherapy regimen of = procarbazine,=20 lomustine, and vincristine. Cancer 2005;103:802=96809.[CrossRef][Medline]
  67. Quinn JA, Reardon DA, Friedman AH et al. Phase II trial = of=20 temozolomide in patients with progressive low-grade glioma. J Clin = Oncol=20 2003;21:646=96651.[Abstract/Free Full Text]
  68. Murphy PS Viviers L, Abson C et al. Monitoring = temozolomide=20 treatment of low-grade glioma with proton magnetic resonance = spectroscopy. Br=20 J Cancer 2004;90:781=96786.[CrossRef][Medline]
  69. Brada M, Viviers L, Abson C et al. Phase II study of = primary=20 temozolomide chemotherapy in patients with WHO grade II gliomas. Ann = Oncol=20 2003;14:1715=961721.[Abstract/Free Full Text]
  70. Pace A, Vidiri A, Galie E et al. Temozolomide = chemotherapy for=20 progressive low-grade glioma: clinical benefits and radiological = response. Ann=20 Oncol 2003;14:1722=961726.[Abstract/Free Full Text]
  71. Allison RR, Schulsinger A, Vongtama V et al. Radiation = and=20 chemotherapy improve outcome in oligodendroglioma. Int J Radiat Oncol = Biol=20 Phys 1997;37:399=96403.[CrossRef][Medline]
  72. Eyre HJ, Crowley JJ, Townsend JJ et al. A randomized = trial of=20 radiotherapy versus radiotherapy plus CCNU for incompletely resected = low-grade=20 gliomas: a Southwest Oncology Group study. J Neurosurg = 1993;78:909=96914.[Medline]
  73. Pignatti F, van den Bent M, Curran D et al. Prognostic = factors=20 for survival in adult patients with cerebral low-grade glioma. J Clin = Oncol=20 2002;20:2076=962084.[Abstract/Free Full Text]
  74. Enam SA, Rock JP. Uncommon low-grade primary brain = tumors. In:=20 Rock JP, Rosenblum ML, Shaw EG et al., eds. The Practical Management = of=20 Low-Grade Primary Brain Tumors. Philadelphia: Lippincott, Williams and = Wilkins, 1999:111=96131.
  75. Mamelak AN, Prados MD, Obana WG et al. Treatment = options and=20 prognosis for multicentric juvenile pilocytic astrocytoma. J Neurosurg = 1994;81:24=9630.[Medline]
  76. Gutierrez J. Classification and pathobiology of = low-grade glial=20 and glioneuronal neoplasms. In: Rock JP, Rosenblum ML, Shaw EG et al., = eds.=20 The Practical Management of Low-Grade Primary Brain Tumors. = Philadelphia:=20 Lippincott, Williams & Wilkins, 1999:33=9667.
  77. Stark AM, Fritsch MJ, Claviez A et al. Management of = tectal=20 glioma in childhood. Pediatr Neurol 2005;33:33=9638.[CrossRef][Medline]
  78. Cohen ME, Duffner PK, Heffner RR et al. Prognostic = factors in=20 brainstem gliomas. Neurology 1986;36:602=96605.[Abstract]
  79. Molloy PT, Bilaniuk LT, Vaughan SN et al. Brainstem = tumors in=20 patients with neurofibromatosis type 1: a distinct clinical entity. = Neurology=20 1995;45:1897=961902.[Abstract]
  80. Berger MS, Edwards MS, LaMasters D et al. Pediatric = brain stem=20 tumors: radiographic, pathological, and clinical correlations. = Neurosurgery=20 1983;12:298=96302.[Medline]
  81. Ree A, Jain R, Rock J et al. Direct infiltration of = brainstem=20 glioma along the cranial nerves. J Neuroimaging 2005;15:197=96199.[Abstract/Free Full Text]
  82. Robertson PL, Allen JC, Abbott IR et al. = Cervicomedullary tumors=20 in children: a distinct subset of brainstem gliomas. Neurology = 1994;44:=20 1798=961803.[Abstract]
  83. Hoffman HJ, Soloniuk DS, Humphreys RP et al. Management = and=20 outcome of low-grade astrocytomas of the midline in children: a = retrospective=20 review. Neurosurgery 1993;33:964=96971.[Medline]
  84. Broniscer A, Iacono L, Chintagumpala M et al. Role of=20 temozolomide after radiotherapy for newly diagnosed diffuse brainstem = glioma=20 in children: results of a multiinstitutional study (SJHG-98). Cancer = 2005;103:=20 133=96139.[CrossRef][Medline]
  85. Alvord EC Jr, Lofton S. Gliomas of the optic nerve or = chiasm.=20 Outcome by patients=91 age, tumor site, and treatment. J Neurosurg=20 1988;68:85=9698.[Medline]
  86. Wabbels B, Demmler A, Seitz J et al. Unilateral adult = malignant=20 optic nerve glioma. Graefes Arch Clin Exp Ophthalmol = 2004;242:741=96748.[CrossRef][Medline]
  87. Kingston JE, Hawkins MM, Draper GJ et al. Patterns of = multiple=20 primary tumours in patients treated for cancer during childhood. Br J = Cancer=20 1987;56:331=96338.[Medline]
  88. Kiebert GM, Curran D, Aaronson NK et al. Quality of = life after=20 radiation therapy of cerebral low-grade gliomas of the adult: results = of a=20 randomised phase III trial on dose response (EORTC trial 22844). EORTC = Radiotherapy Co-operative Group. Eur J Cancer 1998;34:1902=961909.[CrossRef][Medline]
  89. Brown PD, Buckner JC, O=91Fallon JRet al. Effects of = radiotherapy=20 on cognitive function in patients with low-grade glioma measured by = the=20 Folstein mini-mental state examination. J Clin Oncol = 2003;21:2519=962524.[Abstract/Free Full Text]
  90. Klein M, Heimans JJ, Aaronson NKet al. Effect of = radiotherapy and=20 other treatment-related factors on mid-term to long-term cognitive = sequelae in=20 low-grade gliomas: a comparative study. Lancet = 2002;360:1361=961368.[CrossRef][Medline]
  91. Bhatia S, Yasui Y, Robison LL et al. High risk of = subsequent=20 neoplasms continues with extended follow-up of childhood Hodgkin=91s = disease:=20 report from the Late Effects Study Group. J Clin Oncol = 2003;21:4386=964394.[Abstract/Free Full Text]
  92. Armitage JO, Carbone PP, Connors JM et al. = Treatment-related=20 myelo-dysplasia and acute leukemia in non-Hodgkin=91s lymphoma = patients. J Clin=20 Oncol 2003;21:897=96906.[Abstract/Free Full Text]
  93. Hawkins MM, Draper GJ, Kingston JE. Incidence of second = primary=20 tumours among childhood cancer survivors. Br J Cancer 1987;56: = 339=96347.[Medline]
  94. Bielack SS, Kempf-Bielack B, Heise U et al. Combined = modality=20 treatment for osteosarcoma occurring as a second malignant disease.=20 Cooperative German-Austrian-Swiss Osteosarcoma Study Group. J Clin = Oncol=20 1999;17:1164.[Abstract/Free Full Text]
  95. Gajewski TF. Temozolomide for melanoma: new toxicities = and new=20 opportunities. J Clin Oncol=20 2004;22:580=96581.[Free Full Text]
  96. Gerson SL. Clinical relevance of MGMT in the treatment = of cancer.=20 J Clin Oncol 2002;20:2388=962399.[Abstract/Free Full Text]
  97. Su YB, Sohn S, Krown SE et al. Selective CD4+ = lymphopenia in=20 melanoma patients treated with temozolomide: a toxicity with = therapeutic=20 implications. J Clin Oncol=20 2004;22:610=96616.[Abstract/Free Full Text]
  98. Su YW, Chang MC, Chiang MF et al. Treatment-related=20 myelodysplastic syndrome after temozolomide for recurrent high-grade = glioma. J=20 Neurooncol 2005;71:315=96318.[CrossRef][Medline]



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To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_0015_01C696A4.21509550 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://theoncologist.alphamedpress.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else 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quoted-printable Content-Location: http://theoncologist.alphamedpress.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. 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