From: Subject: Transferable anticancer innate immunity in spontaneous regression/complete resistance mice -- Hicks et al. 103 (20): 7753 -- Proceedings of the National Academy of Sciences Date: Thu, 18 May 2006 19:12:59 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0035_01C67AAF.13833830" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pnas.org/cgi/content/full/103/20/7753 Transferable anticancer innate immunity in = spontaneous regression/complete resistance mice -- Hicks et al. 103 = (20): 7753 -- Proceedings of the National Academy of Sciences
3D" 3D" 3D"
3D"Link:3D"Link:3D"Link:3D"Link:3D"Link:3D"Link:3D"Link: 3D"Link:
3D"Proceedings
3D"Link: 3D'""'=20 3D"Link: 3D'""'=20 3D"Link: 3D'""'=20  
Published online before print May 8, = 2006,=20 10.1073/pnas.0602382103
PNAS | = May 16,=20 2006 | vol. 103 | no. 20 | 7753-7758
OPEN ACCESS ARTICLE


=
This = Article
Free via=20 Open Access: OA
3D"
3D"Right OA Abstract=20
3D"Right Figures=20 Only
3D"Right Full=20 Text (PDF)
3D"Right Supporting=20 Information
3D"Right Alert=20 me when this article is cited
3D"Right Alert=20 me if a correction is posted
3D"
Services
3D"
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in PubMed
3D"Right Alert me to new = issues of=20 the journal
3D"Right Add=20 to My File Cabinet
3D"Right Download=20 to citation manager
3D"Right Request = Copyright=20 Permission
3D"
Google = Scholar
3D"
3D"Right Articles by Hicks, A. M. =
3D"Right Articles by Cui, Z.
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Hicks, A. M. =
3D"Right Articles by Cui, Z.
BIOLOGICAL SCIENCES /=20 IMMUNOLOGY
Transferable = anticancer=20 innate immunity in spontaneous regression/complete resistance mice=20

Amy M. Hicks*, Gregory=20 Riedlinger3D{dagger}, Mark C. Willingham*,=20 Martha A. Alexander-Miller3D{ddagger}=20, = C. Von=20 Kap-Herr3D=A7, Mark J. Pettenati3D=A7=20, = Anne M.=20 Sanders*, Holly M. Weir*, = Wei=20 Du*, Joseph Kim*, Andrew = J. G.=20 Simpson=B6, Lloyd J. Old=B6,||,=20 and Zheng Cui*,||=20

Departments of *Pathology, 3D{dagger}=20Cancer = Biology, and=20 3D{ddagger}Microbiology and Immunology, and 3D=A7=20Department of = Pediatrics,=20 Section on Medical Genetics, Wake Forest University School of Medicine,=20 Winston-Salem, NC 27157; and =B6Ludwig Institute for Cancer = Research,=20 New York, NY 10158=20


3D"   =20 Abstract
3D"Top
3D"Abstract
3D"Results
3D"Discussion
3D"Materials and Methods
3D"Acknowledgements
3D"References
 

Spontaneous regression/complete resistance (SR/CR) mice resist=20 very high doses of cancer cells that are lethal to WT mice = even=20 at low doses. In this study, we show that this resistance is=20 mediated by rapid infiltration of leukocytes, mostly of = innate=20 immunity, in both primary and repeated challenges. Formation = of=20 rosettes with infiltrating natural killer cells, neutrophils, = and=20 macrophages was required for the subsequent destruction of = cancer=20 cells through rapid cytolysis. Highly purified natural killer = cells,=20 macrophages, and neutrophils from the SR/CR mice = independently killed=20 cancer cells in vitro. The independent killing = activity by=20 each subset of effector cells is consistent with the = observation that=20 the resistance was abolished by depleting total infiltrating=20 leukocytes but not by depleting only one or two subsets of=20 leukocytes. The resistance was completely transferable to WT=20 recipient mice through SR/CR splenocytes, bone marrow cells, = or=20 enriched peritoneal macrophages, either for prevention = against=20 subsequent cancer challenges or eradication of established = malignancy=20 at distant sites.

cellular cancer immunity | adoptive transfer | cancer = therapy |=20 macrophages | leukocyte depletion

Resistance to challenges with aggressive mouse transplantable = cancer=20 cells, such as S180, L5178Y, or EL4, is rare for laboratory = mice.=20 Spontaneous regression/complete resistance (SR/CR) mice = possess a=20 unique autosomal dominant trait that allows them to survive=20 challenges with aggressive mouse cancer cells at up to = millions of=20 times the lethal doses for WT mice (1, 2). = In=20 SR/CR mice, cancer cells induce rapid infiltration of = leukocytes=20 that form rosettes around cancer cells, which then rapidly = undergo=20 cytolysis. Leukocytes from SR/CR mice also kill a wide array = of=20 mouse and human cancer cell lines in vitro. The cytolytic=20 activity is specific to cancer cells, because SR/CR mice are=20 cancer-free and disease-free for their lifetimes, with no = detectable=20 abnormality despite repeated challenges. From the single = BALB/c=20 founder mouse discovered in 1999, this cancer-resistance = trait=20 has been bred into >2,000 descendants in >14 = generations=20 and in three additional backgrounds (C57BL/6, CAST/Ei, and = C3H).=20 The overall transmission rate remains at 30=9640%. None = of the WT=20 breeding partners and control mice housed in the same cages = acquired=20 resistance to similar tumor cell challenges.

The immune system in mice, like that in humans, is composed = of=20 four major effector cell types that directly attack target = cells:=20 cytotoxic T lymphocytes, natural killer cells (NK), neutrophil = and=20 possibly eosinophil polymorphonuclear leukocytes (PMN), and=20 macrophages (M3D{Phi}).=20 Cytotoxic T lymphocytes belong to adaptive immunity, and = their=20 activation requires prior exposure and establishment of = memory T=20 cells. However, NK, PMN, and M3D{Phi}=20 belong to = innate=20 immunity, and their activation requires no prior exposure but = depends on a predetermined mechanism to recognize specific = patterns=20 of nonself molecules. The fact that SR/CR mice survived the=20 initial challenge with cancer cells without any prior = exposure=20 suggests that the anticancer response is innate immunity.=20 Alternatively, the fact that repeated challenges enhanced = subsequent=20 responses suggests a possible involvement of adaptive = immunity, such=20 as generation of memory T and B lymphocytes and antibody=20 production. For example, older SR/CR mice challenged with = cancer=20 cells for the first time showed a delayed onset of the = resistance=20 mechanism, resulting in an SR phenotype. SR only happened = once to a=20 particular mouse, after which the mouse became completely = resistant=20 to subsequent challenges. Furthermore, frequent challenges = with=20 cancer cells in SR/CR mice shortened the response time from = a=20 few days to even <1 h (unpublished data). The roles of = innate and=20 adaptive immunity and the identity of effector cells in SR/CR = resistance were not clear. Identification of effector cell = type(s)=20 involved in resistance would help clarify the resistance=20 mechanism.

One important implication of cancer resistance in SR/CR mice = is=20 its therapeutic potential. The components of the immune system = are=20 amenable to adoptive cell transfer (AT), a practice used = widely in=20 clinical settings. AT of leukocytes has shown promise against = certain=20 types of malignancy but has limitations (reviewed in refs. 3=967) and = often=20 requires ex vivo stimulation of donor leukocytes = before=20 transfer (8=969). To = evaluate=20 the therapeutic potential of this resistance in mice, = critical=20 questions needed to be addressed before a feasible strategy = could be=20 developed: (i) Do SR/CR leukocytes function only in = SR/CR mice=20 or also in WT mice? (ii) Can SR/CR leukocytes only = prevent=20 cancer or also treat established malignancy? (iii) Can = SR/CR=20 leukocytes act against cancer only locally or also = systemically?=20 (iv) Which organs or tissues provide the most = effective donor=20 cells? (v) Which subsets of immune cells function as = donor=20 cells? (vi) How long can the transferred resistance = protect=20 the recipients? In this paper, we report findings related to = these=20 questions.


3D"   =20 Results
3D"Top
3D"Abstract
3D"Results
3D"Discussion
3D"Materials and Methods
3D"Acknowledgements
3D"References
 
<= STRONG>Cell=20 Type Composition of Cancer-Infiltrating SR/CR Leukocytes. We = profiled=20 subset compositions of infiltrating leukocytes to primary and = subsequent cancer challenges to determine whether there was a = shift=20 from innate to adaptive immunity. We retrieved peritoneal = leukocytes=20 after injection with S180 cells, labeled them with = fluorescent cell=20 surface markers, and analyzed them with flow cytometry. = During the=20 first response, peritoneal cells consisted of 3% = CD8+, 7%=20 CD4+, 12% CD19+ (B cells), 29% = F4/80+=20 (M3D{Phi}), 26%=20 Ly6G+ (PMN), 30% NK1.1+, and 15% CD11c+ = (dendritic cells) (Fig. = 1).=20 Crossreactivity of markers caused the sum of percentages to = be=20 >100%. M3D{Phi} and=20 PMN, as major infiltrates, were verified by counting based on = cell=20 morphology. During responses to the second, third, and fourth = challenges, at least 2 weeks apart, the leukocyte = compositions of the=20 peritoneal cells remained largely unchanged from the first=20 response.



View = larger=20 version (27K):
[in this=20 window]
[in a new window]
  		Fig. 1. = Leukocyte subset=20 compositions of the peritoneal infiltrates during responses = to=20 primary and secondary challenges with cancer cells. = TG-induced=20 peritoneal leukocytes were isolated from unchallenged pups = of SR/CR=20 lineage and analyzed for the ability to kill S180 cancer = cells in=20 vitro as described in Materials and Methods. The = pups=20 displaying the SR/CR phenotype were then challenged with = i.p.=20 injection of 106 S180 cells for the first time. = The=20 responding leukocytes were washed from the peritoneal = cavities,=20 stained with the indicated cell surface markers, and = profiled with=20 flow cytometry (dark red bars indicate the first challenge). = The=20 populations of responding immune cells were also profiled = for the=20 second (green bars), third (brown bars), and fourth (orange = bars)=20 challenges with S180 cells. Subset percentages of total = infiltrates=20 are shown. =

Identification=20 of Leukocyte Subsets in Rosettes with Cancer Cells. Formation = of=20 rosettes between leukocytes and cancer cells is a specific = property=20 of the anticancer response in SR/CR mice and has not been = observed in=20 WT mice challenged with cancer cells. Using surface marker = labeling,=20 we profiled the leukocyte composition of rosettes that showed = 38%=20 Ly6G+, 35% NK1.1+, and 26% = F4/80+=20 (Fig.=20 2A). Fig. 2 = B=20 and C shows examples of PMN, M3D{Phi}=20, and NK surrounding = S180 in=20 rosettes. In contrast, CD8+ and CD4+ T = cells=20 and CD11c+ and CD19+ cells were mostly absent = from=20 rosettes.



View = larger=20 version (126K):
[in this=20 window]
[in a new window]
  		Fig. 2. = Formation of=20 leukocyte rosettes during the killing of cancer cells in = SR/CR mice.=20 SR/CR mice were challenged i.p. with 107 S180 = cells, and=20 infiltrating peritoneal leukocytes were harvested after 24 h = and=20 analyzed to determine which leukocyte subsets were present = in=20 rosettes. (A) Composition of leukocyte subsets in the = rosettes. Cytopreps were prepared and stained with = cell-specific=20 markers for each leukocyte subset. The percentage of each = subset was=20 quantified by direct counting. (B) Contact site = morphology of=20 rosettes. The contact sites between cancer cells (T) and PMN = (arrowhead) and M3D{Phi}=20 (arrow) = were viewed=20 by transmission electron microscopy. (C) = Immunofluorescence=20 microscopy of rosettes. SR/CR mice were injected i.p. with=20 GFP-transfected S180 cells, and responding leukocytes were = removed=20 and analyzed by light microscopy. (a) Phase-contrast = view of=20 a rosette. (b) DAPI staining showing nuclear = morphology.=20 (c) GFP fluorescence of S180. (d) = Rhodamine-conjugated=20 anti-NK1.1 labeling of leukocytes in the rosette (arrows).=20 (e) Composite picture of S180 and anti-NK1.1 staining = in a=20 rosette. =

Effect=20 of Depletion of Effector Subsets on the Resistance Phenotype. = We next=20 determined whether leukocytes were required for cancer = resistance by=20 depleting the cancer-infiltrating leukocytes. We challenged = 20 SR/CR=20 mice i.p. with S180 cells, followed by peritoneal lavage to = remove=20 cells. When peritoneal cells were depleted repeatedly by this = process=20 every day or every other day, up to five times, 19 of 20 = SR/CR mice=20 developed palpable peritoneal tumors (ranging from 2 to 10 = mm) (Fig.=20 7, which is published as supporting=20 information on the PNAS web site). However, 2=963 weeks = after=20 peritoneal lavage was halted, the tumors regressed in 17 of = 19 SR/CR=20 mice, and the recovered mice remained healthy and cancer-free = for=20 their lifetimes. Two of the 19 SR/CR donor mice died of = cancer due to=20 a large tumor burden before the cessation of depletion. This = finding=20 suggests that resistance was entirely dependent on SR/CR=20 leukocytes.

To determine whether resistance required a specific subset of=20 leukocytes, we performed specific depletions. NK or PMN were=20 individually depleted by injection of anti-NK1.1 or = anti-Ly6G,=20 respectively (10, 11). = To verify=20 depletion, the S180-induced peritoneal leukocytes were = analyzed by=20 surface marker-based flow cytometry. NK were absent in the=20 NK-depleted infiltrates, and PMN were absent in the = PMN-depleted=20 infiltrates (Fig. 8, which is published as supporting=20 information on the PNAS web site). Because no depleting=20 antibodies were available for M3D{Phi}=20, they = were inhibited=20 by i.p. injection of 2-chloroadenosine (Fig. 8) (12). = The=20 depletions did not affect unrelated leukocyte populations in = the=20 infiltrates (data not shown). The effect of depletion on = resistance=20 was evaluated by both short- and long-term observations. For=20 short-term observation, we analyzed the presence or absence = of S180=20 cells in the peritoneum 1 day after challenge to determine = whether=20 the resistance was impaired. For long-term observation, we = observed=20 whether mice developed ascites or solid tumors. Depletion of = single=20 or double subsets had no apparent effect on resistance (Fig. = 8). This=20 finding suggests that resistance involved more than one = subset=20 independent of one another.

Identification of SR/CR Mice Without Challenge With Live = Cancer=20 Cells. Previously, in the in vitro killing assay (1), = resistant=20 leukocytes were isolated from SR/CR mice that had been = screened at=20 least twice with cancer cells. One way to confirm the innate=20 nature of the anticancer immunity is to demonstrate the=20 cancer-killing activity of leukocytes isolated from SR/CR = mice before=20 challenge with cancer cells. The design of this screen was to = use=20 the in vitro killing assay to determine whether = leukocytes had=20 tumoricidal activity before the generation of adaptive = immunity. From=20 litters of SR/CR mice bred to WT mice, we isolated peritoneal = M = from each=20 pup by Brewer thioglycollate medium (TG) stimulation (13)=20 and measured S180 killing in vitro (Table 1, which is=20 published as supporting=20 information on the PNAS web site). Then we challenged the = pups=20 i.p. with 106 S180 cells to identify resistant mice. = Of 31=20 screened mice, of which 3D{approx}40% were expected to be resistant, all 16 mice = that had=20 in vitro killing activity survived the in vivo=20 challenges. Thirteen of the 15 mice that had no in vitro=20 killing activity were sensitive to the in vivo challenge.=20 Thus, the in vitro killing assay predicted resistance = in mice=20 without challenge with live cancer cells. A second benefit of = this=20 design was that it validated the in vitro killing = assay as a=20 reliable recapitulation of in vivo activity. =

Individual Subsets of SR/CR Leukocytes Have Independent = Killing=20 Activity Against Cancer Cells. Next, we determined which = leukocyte=20 subset(s) killed cancer cells in SR/CR mice by using the = in=20 vitro killing assay. We measured the killing activity of = purified=20 leukocyte subsets. All purified subsets (NK, M3D{Phi}=20, or PMN) from SR/CR = mice had=20 purities >95% (Fig. 9, which is published as supporting=20 information on the PNAS web site) and displayed killing = similar=20 to that of mixed leukocytes from SR/CR mice (Fig. = 3). These=20 results indicate that all major subsets of innate leukocytes = in=20 SR/CR mice independently killed S180. To determine whether = this=20 killing was specific to cancer cell lines or general to = cultured=20 cell lines, we similarly cultured SR/CR leukocytes either = with=20 CHO cells or NIH 3T3 fibroblasts. The SR/CR leukocytes did = not=20 kill the noncancerous cell lines (Fig. = 3).=20



View = larger=20 version (14K):
[in this=20 window]
[in a new window]
  		Fig. 3. In = vitro=20 killing of cancer cells by purified leukocyte subsets from = SR/CR=20 mice. Individually purified leukocyte subsets from WT and = SR/CR mice=20 (described in Materials and Methods) were examined = for their=20 ability to kill S180 cells in a standard in vitro = killing=20 assay. The effector cells were incubated with S180 cells at = a 10:1=20 ratio at 39=B0C for 24 h. Live S180 cells were identified by = size,=20 morphology, and fluorescence, and viability was determined = by trypan=20 blue exclusion. S, splenocytes; T, thioglycollate-induced = peritoneal=20 M3D{Phi}; M,=20 M3D{Phi};=20 N/A, no leukocytes added. As a control, mixed populations of = SR/CR=20 leukocytes were incubated as described above with CHO or NIH = 3T3=20 mouse fibroblast cells to determine whether S180 killing was = specific to cancer cells or general to cultured cell lines. =

Treatment=20 of Established Tumors at Distant Sites by Transferred = Leukocytes. We=20 determined whether leukocytes from SR/CR mice could treat = established=20 cancers in WT mice. Although our results showed that SR/CR = mice=20 resisted several lethal murine cancer cell lines, including = L5178Y,=20 EL4, and J774 (1), = S180 was=20 chosen as the tumor model system for this study. Some unique=20 properties of S180 cells suitable for this study include the = ability=20 to uniformly establish aggressive, rapidly lethal malignancy = in all=20 inbred strains of WT mice and the ability to form both solid=20 tumors and ascites fluid (14, 15). = We=20 established solid tumors ranging from 5 to 10 mm in surface = diameter=20 or 300 to 800 mg in weight on the backs of female WT BALB/c = nude mice=20 either by direct s.c. injection of S180 cells in suspension = or by=20 implantation of S180-induced tumor fragments with stroma from = syngeneic donors (16). = We=20 extracted leukocytes for the transfers from the spleens and = bone=20 marrow of male BALB/c SR/CR or WT donors. Then we divided = mice with=20 day-4 tumors (verified by histology of similar tumors for = development=20 of vascular networks and invasion into normal tissues) into = three=20 groups: (i) recipients that received a single i.p. = injection=20 of 3D{approx}4 x 108 SR/CR leukocytes from = spleens=20 and bone marrow; (ii) controls that received a single = i.p.=20 injection of 4 x = 108=20 similarly prepared WT leukocytes; or (iii) controls = that=20 received no leukocyte transfer. In both control groups, the = s.c. S180=20 tumors grew both outwardly and inwardly, penetrating through = normal=20 tissues into major cavities until the mice became moribund = and were=20 euthanized. In the group that received the SR/CR leukocytes, = tumors=20 were noticeably larger than those of the control groups in = the first=20 4 days after leukocyte transfer, became noticeably smaller = than the=20 control groups for another 7 days, and then regressed = completely (9=20 of 14 tumors) or stabilized (5 of 14 tumors) 3 weeks after = the=20 transfer of SR/CR leukocytes (Fig. = 4A).=20 Solid tumors often regressed by necrosis from a scab-covered = center=20 (no open wound or bleeding), followed by regression of the = residual=20 rings and complete healing of scabs (Fig.=20 4B). Mice with complete regression remained = healthy and=20 tumor-free at the time of publication, 10 months after the = experiment=20 (Fig.=20 4C).



View = larger=20 version (28K):
[in this=20 window]
[in a new window]
  		Fig. 4. = Transfer of=20 resistance from SR/CR mice to WT mice against established = s.c.=20 tumors. s.c. tumors were implanted in WT nude mice and = allowed to=20 grow for 4 days. Tumor-bearing mice received AT of SR/CR = leukocytes,=20 WT leukocytes, or no leukocytes. (A) Changes in tumor = volume=20 after tumor challenge and subsequent AT of leukocytes = (n =3D 10=20 for SR and n =3D 8 for WT). The average tumor volume = for=20 control mice and mice receiving AT from SR/CR mice was = calculated=20 for each day. Control tumor volume was arbitrarily set at = 100%, and=20 tumor volume with AT from SR/CR mice was reported as a = percentage=20 compared with control. Experiments included five mice with = AT of=20 SR/CR leukocytes (3D{blacksquare}=20) and = four control=20 mice (3D{diamondsuit}=20). = (B)=20 Images of necrosis of tumor centers and subsequent = regression in a=20 single mouse. (C) Survival of the AT recipients and = controls.=20 Experiments included seven mice with AT of SR/CR leukocytes = () and five control mice (3D{blacksquare}). =

Sampl= es of=20 stable and regressing tumors in the treatment group and = growing=20 tumors in control groups were collected for histological = examination.=20 Regressing tumors showed necrotic tumor cell cores bordered = closely=20 by a layer of infiltrating M3D{Phi}=20. The M3D{Phi}=20 were bordered = by a=20 layer of infiltrating PMN, which were in turn bordered by a = layer of=20 infiltrating plasma cells and other lymphocytes (Fig. = 5). Effector=20 cells of the same subsets grouped together during attack on = the=20 cancer cells. By histology, the stable tumors showed a = massive=20 infiltration of leukocytes and desmoplasia interspersed with=20 occasional live cancer cells (data not shown). In contrast, = growing=20 tumors in control groups showed no infiltration of leukocytes = at all=20 (data not shown). Staining for the Y chromosome by = fluorescent in=20 situ hybridization showed that most infiltrating = leukocytes were=20 from the donor SR/CR male cells (Fig. 10, which is published = as supporting=20 information on the PNAS web site). Upon continuous = observation,=20 no lethality or indication of graft vs. host disease in adult = recipients or newborn syngeneic recipients was seen. When = surviving=20 recipients were challenged again with i.p. or s.c. injections = of S180=20 cells, they remained resistant to cancer cells.



View larger = version (112K):
[in this=20 window]
[in a new window]
  		Fig. 5. = Leukocyte=20 infiltration in established S180 tumors. s.c. tumors were=20 established in WT mice, which then received AT of SR/CR = leukocytes.=20 Regressing S180 tumors were sectioned, fixed, and stained = with=20 hematoxylin and eosin 24 days after receiving AT of SR/CR=20 leukocytes. (A) Tumor cells are surrounded by M3D{Phi}=20 and an = outer layer=20 of neutrophils, whereas a surprising number of plasma cells = are=20 observed in the outermost layer. (B and C) At = higher=20 power, small, scattered islands of surviving tumor cells are = observed surrounded by M3D{Phi}=20 and = PMNs, with=20 plasma cells seen in the periphery. Areas of scar tissue = formation=20 with fibroblast proliferation were also noticed. T, S180 = tumor; M,=20 M3D{Phi};=20 PMN, neutrophil; p, plasma cell; f, fibroblast. The brackets = in=20 C delineate the layers of infiltrating leukocytes. =

Transfer=20 of SR/CR Leukocytes Depleted of T and B Lymphocytes into=20 Rag1=96/=96-Recipient Mice. One of the greatest = challenges=20 confronting cell transfer therapy is the concern about how = long the=20 transferred cells remain effective in the recipients. Donor = cells=20 from bone marrow and spleen likely contained stem cells = expected to=20 engraft and survive indefinitely in the syngeneic recipients. = One=20 critical question was how long the transferred resistance = could be=20 maintained by terminally differentiated effector cells. To = address=20 this question, we used different methods to collect donor = cells for=20 transfer and used a simplified model of i.p. cancer cell = challenge.=20 We challenged male SR/CR donor mice with S180 cells i.p. to = induce=20 peritoneal infiltrating effector cells. The infiltrating = cells were=20 retrieved by lavage and injected i.p. into H2-compatible,=20 immune-competent recipient mice. One week after transfer, = recipients=20 received a first challenge of 106 S180 cells. With = each=20 challenge, control mice receiving no transferred leukocytes = or=20 transferred WT leukocytes were also challenged with S180 = cells.=20 Recipient mice with SR/CR leukocytes survived multiple = challenges=20 with S180 cells when challenged multiple times for up to 12 = months=20 after leukocyte transfer, whereas all control mice developed = ascites=20 within 2 weeks of challenge. The potency of resulting = resistance=20 was proportional to the total number of donor cells = regardless=20 of whether the transfer was completed at one time or over=20 multiple times.

We also determined whether the transferred resistance persisted = in=20 the absence of adaptive immune components of both donors and=20 recipients. T and B cells constituting 3D{approx}=2015% of isolated = donor=20 cells were removed by using anti-T and -B lymphocyte = antibodies=20 conjugated with magnetic beads. The removal of T and B cells=20 was confirmed by immunocytochemistry. Donor cells with <1% = T=20 and B lymphocytes, but predominantly composed of M3D{Phi}=20, PMN, and = NK, were=20 transferred into Rag1=96/=96-recipient mice (17), = which=20 lacked adaptive immunity. The recipient mice were challenged = with=20 S180 cells. The majority of recipients survived multiple = challenges,=20 with the final challenge at 12 weeks after AT (Fig. = 6). The=20 ability to survive for such an extended period in the absence = of=20 adaptive immune components in the donor cells and recipients = suggests=20 that the leukocytes of innate immunity were sufficient for = long-term=20 resistance. We further validated this result by eliciting = M with TG = from donor=20 mice. Adaptive immune components were largely absent. The = TG-induced=20 M3D{Phi} = from=20 SR/CR donors, but not WT donors, offered long-term protection = against challenge of S180 cells in Rag1=96/=96 = mice (Fig. = 6). This=20 finding suggests that the differentiated M3D{Phi}=20 may have = potential=20 to confer long-term survival in new hosts. The mechanism of = such=20 long-term survival for innate immune cells is currently = unknown. The=20 effective protection of recipients by enriched M3D{Phi}=20 is consistent with = the results=20 from the in vitro killing assay that showed killing = ability in=20 purified populations of SR/CR leukocytes. Male donor cells = were=20 identified by fluorescent in situ hybridization for = mouse Y=20 chromosome in the cancer infiltrates 3 months after AT into = female=20 recipients (Fig. 11, which is published as supporting=20 information on the PNAS web site).



View = larger=20 version (20K):
[in this=20 window]
[in a new window]
  		Fig. 6. Donor = cells=20 devoid of adaptive immune components were transferred into=20 recipients deficient in adaptive immune responses.=20 Rag1=96/=96 WT mice received total tumor-induced = leukocytes,=20 innate immune cells (T/B depleted), or TG-induced leukocytes = (>90% M3D{Phi}) from SR/CR donors. The recipient WT mice were = then=20 injected i.p. with S180 cells. Survival curves are shown for = WT=20 controls and for Rag1=96/=96 recipients after = initial S180=20 challenge. =


3D"   =20 Discussion
3D"Top
3D"Abstract
3D"Results
3D"Discussion
3D"Materials and Methods
3D"Acknowledgements
3D"References
 
T= he=20 resistance to cancer cells in SR/CR mice involves the ability = of host=20 leukocytes to detect unique signals from cancer cells, to = migrate to=20 the cancer site, and to establish tight physical contact, = resulting=20 in the rupture of the cancer cells. SR/CR leukocytes = apparently rely=20 on a predetermined mechanism for recognizing some signal = common to=20 all cancer cell lines tested so far. The concept that the = resistance=20 against cancers is mediated by innate immunity is supported = by=20 several facts. First, the genetically determined anticancer = response=20 required no prior exposure. Second, innate immune cells = remained the=20 major responding effector cells during repeated challenges. = Third,=20 leukocytes from na=EFve SR/CR mice displayed killing activity = in=20 vitro before any in vivo exposure to cancer cells. = Fourth,=20 transfer of highly purified M3D{Phi}=20 conferred a similar = resistance=20 in WT recipients. In contrast, involvement of transplant = rejection=20 for the anticancer response is highly unlikely, because it = usually=20 takes at least 2 weeks after the primary exposure to the = target.=20

However, there has been an obvious enhancement of resistance = in=20 terms of speed and tumor burden during repeated responses. = Despite a=20 lack of evidence that the components of adaptive immunity = contributed=20 to the resistance, we still could not completely rule out a = possible=20 role for adaptive immunity in the enhancement of anticancer=20 responses.

The independent involvement of M3D{Phi}=20, PMN, or NK in the=20 resistance is somewhat surprising in comparison with the = conventional=20 understanding of anticancer immune responses that often = implicate one=20 subset of effector cells, such as cytotoxic T lymphocytes or = NK.=20 An obvious advantage of such an unconventional but more=20 effective immune strategy is that cancer cells can be killed = by=20 multiple effector mechanisms, and the resistant hosts can = still be=20 protected in cases of failure in one or more immune = components.=20

The second major finding of this study was that resistance could = be entirely transferred to cancer-sensitive mice for both = treatment=20 and prevention of malignancy. Even highly aggressive forms of = malignancy with large tumor burdens could be completely = eradicated=20 systemically. This efficacy in mice suggests that the = anticancer=20 strategy in SR/CR mice may point to a future therapeutic = direction=20 in which adverse side effects of treatment are minimal. The=20 transferred resistance functioned in both immune-competent = (Fig.=20 12, which is published as supporting=20 information on the PNAS web site) and immune-deficient=20 recipients. Our findings from AT also suggest that effective=20 resistance to transplanted cancer cells in SR/CR mice is = mediated=20 entirely by transferable cellular components of the immune = system.=20 The successful long-term retention of resistance was achieved = in the=20 absence of adaptive immunity of either donor or recipient. In = addition to the independent ability to kill S180 cells in=20 vitro, purified M3D{Phi} from SR/CR mice could be conveniently transferred = to a new=20 host for somewhat unexpected long-term cancer resistance. = Currently,=20 the mechanism for this long-term retention of resistance = phenotype is=20 unknown. Nevertheless, this result raises the possibility = that AT=20 of peripheral leukocytes can be used therapeutically as a=20 long-term intervention for cancer treatment or = prevention.=20

Another observation in this study was that large established = solid=20 s.c. tumors in WT mice completely regressed after transfer of = SR/CR=20 leukocytes. This finding is remarkable given that reversal of = this=20 kind of malignancy has, to our knowledge, never before been = reported.=20 This regression took place with or without the presence of = stroma.=20 Together, these findings suggest that the resistance has = implications=20 in both prevention and treatment of cancers in mice. These = findings=20 suggest that the resistance mechanism may recognize a common = property=20 when malignancies are presented, locally or distantly, in = different=20 forms or different cell types.


3D"   =20 Materials and Methods
3D"Top
3D"Abstract
3D"Results
3D"Discussion
3D"Materials and Methods
3D"Acknowledgements
3D"References
 
<= STRONG>Cell=20 Lines and Mouse Strains. S180, CHO, and NIH/3T3 cell lines were = purchased from American Type Culture Collection and = propagated in=20 DMEM with 10% FCS. BALB/c and BALB/c nude mice were purchased = from=20 Charles River Laboratories. C57BL/6 and C57BL/6 = Rag1=96/=96=20 were purchased from The Jackson Laboratory. SR/CR mice (1, 2) were = bred=20 at the Animal Research Programs of Wake Forest University = School=20 of Medicine. Mice were housed in plastic cages, which were = covered=20 with individual air filter tops and contained hardwood = shavings=20 as bedding. Mice were allowed free access to water and = regular=20 chow and were exposed to a 12-h fluorescent light/dark cycle. =

Cytoprep and Histology. For immunocytochemistry of = surface=20 markers, fixed cells in cytopreps were blocked by using = anti-mouse=20 IgG Fab and then probed with anti-CD4, -CD8, -CD19, -Ly6G, = -F4/80,=20 -NK1.1, or -CD11c. These antibodies were followed by=20 rhodamine-conjugated secondary antibodies and counted with a = Zeiss=20 Axioplan2 fluorescence microscope.

Flow Cytometry. Cells from peritoneal washes were = stained=20 with specific antibodies to cell surface markers according to = standard procedures recommended by the supplier and analyzed = on a=20 FACSCalibur (BD Biosciences, Mountain View, CA). Forward and = side=20 scatter gain settings were tuned to sort live cells from cell = fragments.

Depletion of Leukocyte Subsets. For PMN depletion, = three=20 i.p. injections of 500 =B5g of anti-Ly6G (10) = were given=20 to each SR/CR mouse at 2-day intervals. For NK depletion, = three i.p.=20 injections of 500 =B5g of anti-NK1.1 antibody (11) = were=20 administered at 2-day intervals. For M3D{Phi}=20 = depletion, 25=20 mg/kg 2-chloradenosine (2-CAdo) was injected i.p. into SR/CR = mice (12). = The treated=20 mice were then injected i.p. with 2 x=20 107 S180.

Isolation of SR/CR Leukocyte Subsets. PMN were = isolated from=20 the SR/CR peritoneal wash by layering mixed cells over = Histopaque=20 1083 (Sigma) and centrifuging at 400 x g for 30 min according to the=20 manufacturer=92s instructions. M3D{Phi}=20 were isolated by = plating the=20 mixed cells of peritoneal wash in culture dishes in DMEM with = 10% FCS=20 at 37=B0C for 1 h. The nonadherent cells were removed from = adherent=20 M3D{Phi} = by rinsing=20 with PBS. NK were isolated by anti-DX5-labeled microbeads = (Miltenyi=20 Biotec, Auburn, CA) according to the manufacturer=92s = protocol.=20 The purified subsets of leukocytes were verified by = microscopic=20 examination to have 3D≥95% purity, according to unique morphology for = M, = polymorphic nuclei=20 for PMN, and NK1.1 staining and lymphocytic morphology for = NK.=20

In Vitro Assays of Target Cell Killing by = Leukocytes.=20 In vitro killing of S180 cells by leukocytes was performed = as=20 described in ref. 1. = Briefly, total=20 abdominal leukocytes or specific subsets were incubated with = S180=20 cells labeled with 3,3'-dioctadecyloxacarbocyaninine at a = 10:1 ratio.=20 Equal numbers of S180 cells cultured alone in the same = conditions=20 served as no-killing controls (100% survival). After 24 h, = live S180=20 cells were identified by size, morphology, and fluorescence.=20 Live S180 cells were characterized by trypan blue exclusion = and=20 fluorescence retention. Dead S180 cells were characterized by = trypan=20 blue retention and fluorescence loss.

AT of Donor Leukocytes. SR/CR mice were challenged = with i.p.=20 injection of S180 cells. The donor cells were injected i.p. = into=20 recipient mice at a donor/recipient ratio of 1:1 for a total = of up to=20 eight transfers. Rag1=96/=96 female recipients are = unable to=20 mount an adaptive response against sex-mismatched donor cells = and=20 therefore received haplotype-compatible leukocytes from male = donor=20 mice to facilitate tracking of donor cells in the female=20 recipient. For donor leukocytes depleted of T and B cells,=20 S180-induced leukocytes were incubated with anti-CD90 and = anti-CD45R=20 microbeads (Miltenyi Biotec) according to the = manufacturer=92s=20 instructions. The T/B-depleted leukocytes were transferred to = four=20 Rag1=96/=96 recipients for a total of five = transfers. SR/CR=20 and WT mice were injected i.p. with 3% TG to elicit M3D{Phi}=20 infiltration. = Three=20 days after TG elicitation, the infiltrating cells (>90% M3D{Phi}=20) were = recovered and=20 transferred to recipient mice for a total of 10 transfers. = All=20 recipients were then challenged with 106 S180 = cells.=20 Splenocytes were obtained from SR/CR or WT mice and = transferred to=20 recipient mice at a 1:1 ratio.

Acquired Resistance to Established Solid Tumor at a Distant=20 Site. Six-week-old female BALB/c nude mice were used as = recipients=20 of cancer cells and subsequent adoptive transfers of = leukocytes.=20 Solid s.c. tumors were established by injecting 2 x 107 S180 cells at = two sites=20 on the back and allowed to reach diameters of 5=9610 mm. = Leukocytes=20 were extracted from the spleens and femur bone marrow of = donor mice,=20 according to standard protocols. Four days after tumor cell=20 transplantation, isolated donor leukocytes were transferred = i.p. with=20 a ratio of two donors to one recipient. Each recipient = received 4 = x 108 leukocytes, which = accounted=20 for 80% of the estimated endogenous leukocytes in a mouse. = Tumor=20 volume (V) was calculated by using the formula V =3D = (Wx Wx L)/2, where W = was the=20 shorter of the two diameters and L was the longer one. = Tumor=20 volume was reported as the mean =B1 SEM. Moribund mice with = tumors were=20 euthanized according to Institutional Animal Care and Use = Committee=20 guidelines. For histological evaluation of stabilized tumors, = the=20 remaining tumor was removed 28 days after tumor injection (24 = days=20 after AT) from the euthanized mouse and fixed in 3.7% = formaldehyde=20 overnight. Tumors were embedded in paraffin, sectioned, and = stained=20 with hematoxylin and eosin. Data presented are representative = of=20 results observed from four samples.

Identification of Male Donor Cells in Female Recipients by XY = Fluorescent in Situ Hybridization. Fragments of stable,=20 regressing, and progressing tumors were embedded in paraffin, = and=20 sections were mounted on glass slides and deparaffinized.=20 S180-induced peritoneal cells were fixed to slides. Slides = were=20 processed according to standard cytogenetic methodology and=20 codenatured with mouse XY whole-chromosome probes (Vysis). = The X=20 chromosome probe was directly labeled with FITC (green) and = was mixed=20 1:1 with the Y probe labeled with Cy3 (red). Finally, slides = were=20 counterstained in DAPI.


3D"   =20 Acknowledgements
3D"Top
3D"Abstract
3D"Results
3D"Discussion
3D"Materials and Methods
3D"Acknowledgements
3D"References
 
T= his work=20 was supported by grants from the Cancer Research Institute, = the=20 National Cancer Institute, and the Charlotte Geyer Foundation = (to=20 Z.C.). G.R. is supported by National Cancer Institute Training = Grant=20 CA79448.


3D"   =20 Footnotes
 

Abbreviations: AT, adoptive cell transfer; CR, complete resistance; = M, = macrophages; NK,=20 natural killer cell(s); PMN, polymorphonuclear leukocyte(s); SR, = spontaneous=20 regression.

||To whom correspondence = may be=20 addressed. E-mail: zhengcui{at}wfubmc.edu or lold{at}licr.org

Freely available online through the = PNAS open=20 access option.

Contributed by Lloyd J. Old, March 28, = 2006=20

Author contributions: A.M.H., G.R., = M.C.W.,=20 M.A.A.-M., J.K., A.J.G.S., L.J.O., and Z.C. designed = research;=20 A.M.H., G.R., C.V.K.-H., A.M.S., H.M.W., W.D., and J.K. = performed=20 research; C.V.K.-H. and M.J.P. contributed new = reagents/analytic=20 tools; A.M.H., G.R., M.C.W., M.A.A.-M., L.J.O., and Z.C. = analyzed=20 data; and A.M.H., G.R., M.C.W., and Z.C. wrote the = paper.

Conflict of interest statement: No = conflicts=20 declared.

=A9 2006 by The = National Academy=20 of Sciences of the USA


3D"   =20 References
3D"Top
3D"Abstract
3D"Results
3D"Discussion
3D"Materials and Methods
3D"Acknowledgements
3D"References
&nb= sp;

  1. Cui, Z., Willingham, M. C., Hicks, A. M., = Alexander-Miller, M. A.,=20 Howard, T. D., Hawkins, G. A., Miller, M. S., Weir, H. M., Du, W. = &=20 DeLong, C. J. (2003) Proc. Natl. Acad. Sci. USA 100, = 6682=966687.[Abstract/Free Full Text]
  2. Cui, Z. (2003) Cancer Immun 3, 14.[Medline]=20
  3. Morris, E., Hart, D., Gao, L., Tsallios, A., Xue, S. A. = &=20 Stauss, H. (2006) Blood Rev 20, 61=9669.[CrossRef][ISI][Medline]=20
  4. Mocellin, S., Rossi, C. R., Lise, M. & Marincola, F. = M. (2002)=20 Cancer Immunol. Immunother 51, 583=96595.[CrossRef][ISI][Medline]=20
  5. Knutson, K. L., Almand, B., Mankoff, D. A., Schiffman, = K. &=20 Disis, M. L. (2002) Expert Opin. Biol. Ther 2, = 55=9666.[CrossRef][ISI][Medline]=20
  6. Locatelli, F., Comoli, P., Montagna, D., Rossi, F., = Daudt, L.=20 & Maccario, R. (2004) Best Pract. Res. Clin. Haematol = 17,=20 479=96492.[CrossRef][ISI][Medline]=20
  7. Ruggeri, L., Mancusi, A., Capanni, M., Marelli, M. F. = &=20 Velardi, A. (2005) Curr. Opin. Immunol 17, = 211=96217.[CrossRef][ISI][Medline]=20
  8. Chang, A. E. & Shu, S. (1996) Crit. Rev. Oncol. = Hematol=20 22, 213=96228.[ISI][Medline]=20
  9. Overwijk, W. W. (2005) Curr. Opin. Immunol = 17,=20 187=96194.[CrossRef][ISI][Medline]=20
  10. Conlan, J. W. & North, R. J. (1994) J. Exp. = Med=20 179, 259=96268.[Abstract/Free Full Text]
  11. Koo, G. C., Dumont, F. J., Tutt, M., Hackett, J. Jr. = & Kumar,=20 V. (1986) J. Immunol 137, 3742=963747.[Abstract/Free Full Text]
  12. Kikkawa, H., Imafuku, H., Tsukada, H. & Oku, N. = (2000)=20 FEBS Lett 146, 211=96216.
  13. Leijh, P. C. J., van Zwet, T. L., ter Kuile, M. N. = & van=20 Furth, R. (1984) Infect. Immun 46, 448=96452.[Abstract/Free Full Text]
  14. Tarnowski, G. S., Mountain, I. M. & Stock, C. C. = (1973)=20 Cancer Res 33, 1885=961888.[ISI][Medline]=20
  15. Alfaro, G., Lomeli, C., Ocadiz, R., Ortega, V., = Barrera, R.,=20 Ramirez, M. & Nava, G. (1992) Vet. Immunol. Immunopathol = 30,=20 385=96398.[CrossRef][ISI][Medline]=20
  16. Singh, S., Ross, S. R., Acena, M., Rowley, D. A. & = Shreiber,=20 H. (1992) J. Exp. Med 175, 139=96146.[Abstract/Free Full Text]
  17. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, = K.,=20 Tonegawa, S. & Papaioannou, V. E. (1992) Cell 68, = 869=96877.[CrossRef][ISI][Medline]=20



=
This = Article
Free via=20 Open Access: OA
3D"
3D"Right OA Abstract=20
3D"Right Figures=20 Only
3D"Right Full=20 Text (PDF)
3D"Right Supporting=20 Information
3D"Right Alert=20 me when this article is cited
3D"Right Alert=20 me if a correction is posted
3D"
Services
3D"
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in PubMed
3D"Right Alert me to new = issues of=20 the journal
3D"Right Add=20 to My File Cabinet
3D"Right Download=20 to citation manager
3D"Right Request = Copyright=20 Permission
3D"
Google = Scholar
3D"
3D"Right Articles by Hicks, A. M. =
3D"Right Articles by Cui, Z.
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Hicks, A. M. =
3D"Right Articles by Cui, Z.

Current = Issue | Archives = | Online=20 Submission | Info for=20 Authors | Editorial=20 Board | About=20
Subscribe | = Advertise = | Contact | Site = Map

Copyright=20 =A9 2006 by the National Academy of Sciences=20

------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/spacer.gif R0lGODlhAQABAID/AMDAwAAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/adsystem/graphics/1147972349705/pnas/KeySym_PNASbanner.gif?ad=5255&adview=true R0lGODlh3AAoANU/AJifq6vJ29Hj7k51mcvP08bb5/X4+bnS4nSSq2ejx+To6zGCs0OMuom201qZ wa24w5O81XGoyzyFuZvC2lSVvu7z9DmFt2Gew+bu84yzzYOrxJ+1xkuSvm6AmVyEpS6BsUiErlKN tDSEuj+Hu3yfuevv709niDiHv/Lz8pqruzyJt3itzj5+rOPk432wz4Ky0e7t6zWIuu/v8d/h5L7C yNfZ24SHltne4TiGtzWDtCx+rjaEtTeFtv///2ZmZv///yH/C05FVFNDQVBFMi4wAwEAAAAh+QQF 9AE/ACwAAAAA3AAoAAAG/0CfcEgsGo/IpHLJbDqf0Kh0Sl3yrtisdsvter/gsHhMLpvP6HRXWGZE 1PC4fE6v27NsckLAuPv/gIGCX3lcHFsrPRCDjI2Oj2OFWQwTGBCHWA09FSuQnp+ggJKZPT0Yb1gH pQFnLwIvWBcCrzyys7cCrBMCE1m7vbUFpRgHfTwBuLesPJQYpbRYyItYs1fIyQIXXCsCz8A8BQKd WOGdt7DWs8vY01iuwxPGV9zesblayN+EPtulCpjMFJTSV4sCmAk9gF0w0OPAlQSlIj7jQYGhQYo9 DBis2GMWQwFXukmcyEDkrFIOQ5a6yKOUypE9EiB6JhJYIgzuOl6JWAALQ/+dLWGm5KGqo0ljiYwO fAj0CoOI8ryM4uEgQCkDCVTwwIEQJUBwB3B8QdhrYUMsEEFyQai2GzAIPZYxYKgNC9ksVvlcMTvO JBaXPLrJBCNsHEQD1BIyYzh4WA+mztQC5pHUYCIDdUvGvVKYKWIeabPAZYhu3xYXzoY16AM3YgCt VBmPTWh2KOimWwSHvsK27oUEUe/67MGSx4sePQNn7IEOsOAw3Q5cTDCYogEDlDbvbBiTB0JVkh8n limsNMbP0acP3n3FGdswUy8IHBZB64XUFerisIqh+lrkPxUHEQYTFFggSwM6Ux0FERHjH2+K7YUb MxmphBB2Qal0gIETmJf/0zMBFOddRxnJU8pxrHRzXHhYcKQNQ1Epp81xICLY1AXI8WARGKPs99Mw FzBQ1CpXOMBQBS7MdhVuEMHkn1VnZbFCas8EF+FtamXhXExWObTlSFlqMcGP2iXGnJbEdfRUf0DR 5FeGWjznHZnLsKcKLKq0swY/k+wikUY4SiSATA38VICIvjxDgTPjYEndo1E91UOMDwWQmj7CYbnF lsAxtiUEjyZQFxcMrHDAT/4lEmaGzhx3wG4jYRCAMZONh0Wpp5Yi025z9bBCAgjhZJoWDggTUS8M NDBfBQFoE0FEBjS6BUIF9HGZMex1USto+sAVZqaSRqWqSjLdxCkYpZon/4w+2WaoSquwipebr5O4 lG4W62pqHEw9jMrFVBwMidxqEVQwDAMq4MCBwZu4ANu0V3ZT54SbytueIjklB6E+wgyl2TRyiiSe nF4w2G8qGKM1oUs0EhdvF97Ko0pPJo+ap77RGRjdsFncF2upgvYCgaEXiPXfNy7eZgA2Wmzb2oZF SZupdaZMYGlTcnI0slG4eAhORgH4qVEW7do70ctddGNA2GpfJMzaYhsUGoOfXUE3z0VS6RoFxka0 gmalVLCa0WJeOSJITcLUtMW8/WiAh1PXInJD8pDc1UsjEcSMwBj4q+9fW7OCNqkCZ3Mr53WFZtUy iUmrxSgR6L0KB5OHdf8Bw1cd8PAj1HkeBgXUUVoHA9QhOgjxCRiPvPFqACz7K2QOqkICZFYbyvXY Z/86n2gVQGYF9Ql8KA+FStSA9uin74kkKjw7UgUOUDB5AQ4AHpEASaqv//5+SJJAAbLDwArkB6bY wURz/EugAsswigQI7CwLK6DsDKCnLTDgbQiEAwNgAZEyiKolD+JCApzRuWmtilQcfMxCsMI4LcjC FK7zAy8oEsM9ZcEBDzQFA4w0kgJw4AXVc8AXDiAOuHgNDrugSAa1JZPugMFB1dBCAo4oJpBQoBe7 uMAVv4CBAjiQOIJ4gUxmKAZJdGUkBpiAJkbSrL5dhYoUSl0fdlGMY0D/4AB1fEUBbCKAOl6gHDzA wNpkYZywFUAbF8RjaVaEIwiQkRt1/EsntiikGb6AFZXsxCUncMhADhIkgmyWWugojxXUrROVBAYv XpHFYwSgAAHgBiwISchNdjIAL1gIgQRgkALUkAeSuIAqvpcADkCgABU4gAI6F4HJlQIVImQcEC3l EAGkEWMdUYUW49LHQBZAGPLDgBgfgxBL9SQcVvkGRKTTEatsExm2CYABXnUFIlrlBUm0J3HK2cXA iLODAvjnY4A4pqEkMQsHkNXjWiIAYYSjJ9bMi/duQ1F+QnQCixqUOBnEPPat4JjP+GYfcLAC+KmA AWIBokQqcEKVxYkV/6YMTIp6Qa+YVGICqoBIH7SRxA4mMYn0IuNOmtgJmxJIFVp4gTBYQS+egqQh N/0pSHpKTsQ95h4UkMdBJXmMnsREp0mcoa86SNaqegckM5zhK10hFe5lIQIRUEAEGFBKAwjxChxI jQEUcIAIfEULT6mLOGYI0F6ItYnAIlCBOliLs1Z0qk8doz66Q9nEGigLg6LMY7rj1JZsaALAgqxj fWrVwPQiq1iIKUV42R2gUseshy3rYx2b1rLMk3VbmIpTBHDX1GIGC8ZcgaVQC4ZZfPGKAmyoaZdb 2USYig9phMsVxUFa2vrScIrAEWKdS0R8DSqhgfHl48Iq3tA6dhe/Mv+rT/vTTafMcw84mcWUFvFV 2NL0tbd5AVKlutw+yuQ6IcSCbnlAO8+ZMoSx+2sXLpgRWGiGl/29LwiPkRFNXmcR1GPheUGykFlw TBGVpXC0etaN/tTCGQ5Jos9E21MAq/cxDy7OC0vos5TUl7b3Zaw19yvaGcKlJ6fCWxYooADPRQAr iMCAgvcXy8BUcIHqu6DG/uXWGyqgt1c4cgintGT90WhsUOafgoQciytLEclamJLw9ge8NYc5e1rk UZVjgQEs1yI/W0jwm/fMZyp34T4iSgCetaDnPhuazwOWz19N6TsuH/rRYR5wAv5B6N9qATVuhrSm sTfgTXv6053+tKgQH12FUpv61KhOtapXjeogAAAh+QQFAAA/ACwBAAEA2gAmAAAG/8CccEgsGo/I pHLJbDqf0Kh0Sq0OVRerdsvter/go4qBEzoCv7B6zW67m5RLYu74JQqrp2Ouekf3XYBPHAkMb2ND HEKEhmE7j5A7Kg0FPxQMexQRBQcXkZ+RDAkOZKCmp6ipqo8cHKuvO3uwjwwcKrO4kSoJrrEJtLa5 wpARAgKdjw4UEAUCEw4OvSq2FMo4KhSjrhEHDaQ7FAEBK9DiB+fiDRwNB5Y4jy/tpBQTzQUBvezo 4gENj8sHmh1woexWg3GSbJ17NGFfgHMUduCoFm3HhQPGAkBwxUDchVaYPO4w12Aag4P9djA4d4Df CkwVuRkr0GCOLQY/Ah7zNq8fB/9o0yAEeEGxF6wExg4wgKQiQDNLmXb8WJGgWlUsCS5EhCAAghwH zQKMumCsrIB7CTYJWBGRg7ELF1YU4KTzwC2MZjNKwnivmbOsI+cyEIVUQCy8M4058PUzrUC8EHas O7bngouzt8qK5TX33q68YaElqHcWb4EIDlT8yAh5zgVOo7IVa8Zrj1FVk886eLfDhd8AS/c0tSRx lEpekla/wOEbbfBj77KNqfqC8kgB/iZhv9oswg6bDQS8iBS+wK0Ecgu8+OX0niiw5hMElBNRlkQV 0xI4hZugegHJ+lWSwA/NvLBUUgUQsklAwBWGn0XGuOKfbU0J8MMjAQjgnQP+ZUP/IDKSTXBWVzfN Il9ZB0QwxmVlNWABIQRq+IhxonC02g8sQmCfA8fMMcdgyGVIzllL7VDdQHO48IInhAyIXSTNrDCj A8WIdV2UvBgjCkbrLWZfk3JgBIEdWS0GY3fVTVDIDsZwZQdXXAUAjjFZ3SXeiRHUKJkxj2A0QWPQ wGidSsYc6dptqVCAWCeirGDaYtlwJeN3i+mpmjN+NZZMoS90+oIdrvDIiXhLqcDjTDoWiR8DbkJC QY9TriYAe+KdFYFbAuwiZgOd/hDZLruJIutZdrBSyJG6rWlMMRDgKYCcKhiTTTTS7vCUnjtgFNGw 7bgiKIiryflUk6/8QIlZBbgQ/wFpbSro14WUHtfLsBntmJcxoD4iq5oXYJIWYpThkNVJFkLC4wG/ xEvndQ6Ehw+fF917gCQD2/aCX20CuJRftyorAFmnUfasKKzhdQAHDPD53lIY/TBNjC1+y0tHFuKQ oYFwvaLCCxmaFQHMMxGl1rOu0IjcDuGdFfF6mx7wAq8/RHN0MRYyIMdH+opYqCRyrOZP0wkbt3CG dXTHpwp+ouaACy78M0ccu0XQADNvMWLkMRqzOWszcPIoJ64oNiBHYckYl2FJhBDSs4ZOBiAbvg3T mRos4ZSlniSOzuQNhDMlbEqaFyJVyaZypsJnJBxGssKzkVQ3nr74RoJU6WR/d//M6bWnYod3kIj4 Oumf8Cmphn4/cjooGHkuFZ+7R+J7LCPvQHVeEc3CKsYTqBjxMT/gwENOnUtwiuuQHA686YZFgpGU jxQzQeviOd8VJOCzn/viGAqwWCq4Vr8DV+w7HyTekjQB/IR1ejvF6toBCa68r38NXAv0EPaaZ3kq Q5FBxQ82yEFFoasdhTlLP6bil2d8j4ModB0HOdAMCkRNhPwQBwplNcPVdeUFkhoQB1W4QoE8DSPt 2CDZNshCfP0gQy2J4c9mKCKa8OwsHECh32YorVPJ41kbNOIMN8gXXvElij9oIq8ylKAXAgdkOFgh sbbIRkvoxCzqWBydjoiiJbL/kYcbPNIL72UhFGpxhxg7zQzxuMHKlWVMHBxiHo0ox7J8aovDO4YL pYhFP/YRIw0wYxb72MZIOg6FkTzAJKcYnkyiMHlt3KJ8MGaMBtDskFFjZQEQmcpa2tKW0JjkLVcI jV36so2B+oEFLCCCXxqTjcFEZjSOecyV5CUAQ6uXBSpYlgmohpnYzKY2tamvYW7zm+BkpgPYNZML hNEsfyKh5ewYzna605Y4SOMGRZCDYVqAft58pz63Gc94/oAseRElB+T4yUZCs58ITahCF8rQhjr0 oRCNqD8hIQRsUCAEFKAAByRgT4dyUKIIvZBIOUi/LYL0pPa0wDgB1qOBPnN7/3BMqUxnStOa2vSm OM3pMBPa0YSmAQe1aIUD4KKMoVIABCyQSj43iINhSkIF95RKGndaU6aqYAT4kYAE8MPVrEpAno/o pwXSGE+d5nScrJyABcBnFrGwFA83Pad6zErXH0RgmgKg6zQpYIGPpXSD9hTmP4FIARFYwF/y+Sc0 lJHREIAAqTmw6z8FMAIKzCUCJcDoYO7Z1Hh6EGGPoCc24ELa0pZ2sRplgPh2QNOhvCgBeh0mPSRm CVaOLJrO4KtNIYCw1d3Vpk3VK89e9AK9+tWvKU3jDooZzwNM4AIP4QB/5tCAZyw2l0dFKgt4JpUf hCADKRpQLjUrkTQ61wFcIf8FAygCDdO6d3BZuYAyiiQCpeIgAhewgGtjW5170cSGcBwnaH67Vpmu RrfmtADPxmSBBqwAAgyG5gSKawH9MJgeYrFAQBoQDgvI7QUT4GsYIUzgYohyLfu1MAcsoAIJjEAB RIHuBTZxxHF6t2zeyMAR0QCCgExALi4sgR0KEIIzEOCffRDBHRJSExpvYKg5CSMa1nOOnIxJTS74 56fqAIHq8rUBEbCs0/BhATXldLay7NcKnNKQA+zBKXlJQHDTKALDTvYRO90EO8aUoR9gYAV9PQBX NIodQWt4AiIaaIrIouBCq7Uh4aEwXjeyEwEQmhKWcCwLNnCDfsyhAAr4gQz/MuCUcGywAvoRMmUO cIMJjGlACoCABlCwDCFjwLuD4VkcfFSJA1TguQbYoAEEEOoBVeAABsCAhRLQAAM0zA4BCPazmvIC DrTkIrcy4FgRutN+SgA9WhPHBLr37QJQYASAxe09vDkYqI5gBGTBz4X0W5JNMIATDjhABnIwq75e IB44/FjNKIADnuGALAU/QMEDgINZ4cBpCD2unD92sQ3S+qIsYAEJHiADhP0gAyEYBW8pIIMjKgAN 5t5gAphxAQgYwNQccmPUIhDfM5DJR74akJtR8DQD6McOR7yAAbpsh2ZfIJPyUcAqLbsRpzU4e+0Q a7cXGqYLoHvbdyB4U1dS/wBlC3pAYz1sCIpc1Aq4QL4pEjQFXoACc/6gxxlgwccaziGndQrhE1n4 wQWgd4PPfSgRv0DDBf+xH4TaV2N3bAAuoHEZXAAFGghBmB8Cghlo5AcaAK+pWy7KT0G3ABySgaIW HwGaw+XV6PmzATiscnO53OYDWvzqkd7sZwdIPzd4zeILOTsIcLSj22boEbXezzs4gN06/gEBohjV HIxg7JWBi+EpYYAIoAGRF9EA3EGQexYogOazEgqBXrA6DsQjK3w3uMGdi5Tl9HMtrzo+BiKgAQVo ICePBUEIztHyj1WiARhwf0R2AwegATNAAuC1f0TGW3bVdk7hACTQApMEgP8FQFo/M0u3Bh/3t3go 4AINgAKwF3Sz53MfyAz/pHJoYE67RxMJUAEYQBCptVpT51NuJnXGF0+VBQ0aQAAhIAEg0FgYNVSl NSAGUAJe8TMGUABVUYDbl3uVlydcoYT3NRcrcHBzgXDqx3BiBnFl5Tt/RnIRAAIQoAAYQAKPxQAg kBMzcBoQ+AMGEAAhQCBrI2oH8F2d8BAscAE3oCEyECCSl1k6NBWk1R8YEGxhFgE3kIQXJQMa8AIG AF0nKHud4nOWVQKVYHOQqIKQuDcVYFrRgDJftVDWdnz9FANI8QMctV4XpQE34FhFVibvdVqklVEO kHj5d4u3OAKbJVXXpC//8tRZ8VQTGiYlFzICjVEVtphxiedY2vVYIfAVY/eDGKUVP3gBRSZf2pV4 lTF2GZUNPjKErtGNZHdRZMcfg2iOVyOErnE1gyNf8EU1phVf8lVTikJwLLZVK1ACK9AKtNhyUWNU y3iNsUhUrpiM+qdpGZd/0bhe0fBug8EAXLVTFxIBCqAAs9KN8OWK1sgCaCiNjnVRzQgXIHlR1UCS cxCEIKl/VmGN17gHPiKPL6kV10WO/ZiO7AiTg5gV3+garzgHG1QT7JiT9Hgy01AN/1YCGiCEQ7Vy diVfmqaQAklUQkiNLICSIZCQV5lxLPBYW6l/47WUZaIMtjAGcbACYPaS/1kRjUV2VByZXVrxjBup jLU4dllBEfzRXhdwi9coj4uFljnpGtdFdlP5jfEYXzCpk4RpjfBFfn55k93jTxyUbxq1lBD4gjnp jzR3lVyplSqplIGpXVuJUcy4mV2plYKZjrQoj/CFmN9Yi/rnlLeIhhQRB1n5mnTpmns5XXQAfdPF ki7ZjqsZk0GIl4OzWAM5i/IFlslpnH8Zk4MIkavSChywCb45Cp+yJOmIXoK4WLUplyTZjblEmqHJ lZt5i7tWJuQIl7qJlqypDLzpmuT5WEalDF35g3swl84YnD5CkkUFi+F4XeyZnUOljqMQhLIInAmA UexlnEUllfqpm8vZXv9UknsXRVQQYHbsOFRjgl86uZEZ5Yy1KI4KCpJaOZ4lqpI9WZfDCaH6+ZJz aaCjGZ/6d5B6eZIHSaA7SY0g6pe5BJbfmJphOaARSpwRejWvCTcXhZdB2qKreV2MpQH6M3b8caFn Z5ijYVeHmV3VAJosUJLO2FigOaMJeZ6uERs4CpiruZ6Jl6Qxmn8nOqMKaY35543OSVTdyADPWKaq yZ6x4V54qZzumKFG6ZREJZPn2Jd8yp4M6pUgmad6mqh1KpJgeqIYF5rVgJD5hwng2KDg6J/O+Y0B 2aYYhVRcioujiqc/waJviVoHaZQ7mahL+V5C2psIGpRpyqMtCqujAA1FRVaQtwqpegqOsFmixFqV FKGZUhqPDtCZPtqc61haQHiQyxgH5OimWBkCeJqeNxmss9imceCsPqKkskqk8BWLwHquiRoEACH5 BAUAAD8ALAEAAQDaACYAAAb/wIVwSCwaj8ikcslsOp/QqHRKrQ55HKt2y+16v+Ajg6MScly4sHrN brubjsZkvvpRIJena854R/ddgE8JE1luDBRDCUKEhm84dRMOHCsTCQ4QEIlMHBMrHD9+UA6LXIJO HAmhbQyWQpVmqqIOBwUQhisRERATEC8rDkI/CQwJLqo/ERMvwQ50WQyZPy4XLg0BAcsuEQnKw6uE P58MKxAHBxObEdjZLu6lFw0N5hDTEX3GecMM2EIQ2BDcBSjQJ5m7PBQCoJOXp1MDCg4cUKijaYGL fxCKpXq3gAO7gNQouGs2EF05Sz/OzGu3YgUFBscc/CrmTtdBKBQKHHhRRgiO/xcQdCaotOhHr6ET 7slpECHHhAI/5PwwdyCg0R86dWaaozDpAgYFCkSQ02vgQIILsJ7TOcfFAhxYreo02sBiJhWdgh5Y sCJrgV61slxEOrXWhFp1E2BrcLHBC6ihaqHjlSCTVb1hA/w70LJX0B8/DnR9AfNHABdn50niNWEb r6q2kJZiUkwrhx0Lclz497fMiwlRk6Vd1tFSDgbnVCmsV6hjrVDeOnF7+mJB0Oo/fiuLgOP6gl4X 1iXIkYPRgR9p5mydYDdgJ6DMe1Hw+lsYaELyV1ZdQEgacHMBZBHWPBd4AsE8LnRSQAAM9JFTAWU8 hYclP51DHnCLvJANBMrsFv9Vbhcst+AFYyRB3ok5xBHWBA1cYAEFypwXQAQ7hAPcChe+kEMn43Fw nmhhRfAbeRysOEchPObQwFQ+pkRef9lMgI2OmBxWgI4nBjVBjs4YlcMevCiDn4KmLZPDkDlU1suR ETgjCQdproZOf4XkgFWHLCbVWg4RgMYinFBlA9okxoFVwIXZMfAbB6lMUOCVRAoVgFG9OIDipZdy 0ICMD3XC4qQB8unJQDg6pWOSPnL2zwSKbrljLQl0w40zPYZ2TQAUHEcIqBEwSl6Dmi54YitemqrC YVvugZ8lc3SSTQQrxGrajp7gBdwcP7rwZCEJrAhBIzmE5Ywc2TijrbPKrGD/KANOTWDteHb+wC5o gh7ALiEFRvWkl3OQkgmm5IEmMA+7PKVTlGSF9UKBK13p5wspoWTagpK98BtoHoV21rXIGNYYJZY0 kFktEaiQCQWPTYqxlMAZBfFTwC26zgH4BadQaAZH3AAHv8U66TnZDVNIaEaRMvR5Mx+28zIKZrOg lRdQgFXEn5gGWjHoPGXUdEZlkwAF5/2gQi0uSSPw2WgP89thcS17sycFTsqqyxEj0xdoK8jBy8rZ ZHMBB/MhA7MKd1QKWohQ0ZySHGQL7GzLyxj1V3aFHCvOHCn9/AKj/4CmDIe+HBtAOWFR0MhUwZ2O rMYH9Bq5A5AtBO0ck1NO/9GCjVIg9V+eXPsLttlRsuLmaRcv7x5HIhOPer3acSQEDhgv9AoqOA9B 9RFDLD2laKdydoHa3yex2HNgD9p82i/qPFmgqb894dELTNTZ76GNTTIlEao95sXLIbXAxwIO/M42 P09JzQE/O9LQtoc2FSjjSNSwA2saoAIe7CAa6nEAXIpHCGRQrk/ZYyD/BCaHCwjMGXUQWAcJmBQA lrB9C1xby9wnvVYsMBmOol/kznYeOaxoDDscIdoYZr50yatZAutQxOawKZ1wIwHa2d4OpkhFTSmw Fypw0xxekIAdFKgtoKCiGGtkCSpi8DZ5sZgaXzDGOYzxi9x4IAXE2EExYv/wWwVrABUXNUUMTmCK v3HMGh0wxh1UgkNQ7AUDxPieNgagG9nQYyN34MZCTlFv3NDbIg3ZC278JiM7eA8HIiAaFZixF5ak YvfIosB7yLBfKmAlHirIwfEJbUnzuaIQuYc2NWWwl7ZMySupJ7Df/E9oM9RlMMVWieeB4mzoQxv/ 5NCnaPKyeCpo5hafyUwF3uJ8kdsO2uQQPwbagZVsotyRVoAF1qhnBRs0pzznaQcKcHOeiKCA+ehp TgtY4AcjsCcD/snPgqaNcC/Bpu4YYNCCopNFVTrS5nBQuHU29KIYzSg/RTBFEfyAoATVqEhHWjwc mNSkZ3CnfCChQBcwAAf/XzzSBU5K05ra9KY4zalOd8rTntIUNDvAwQ5CsQMJ/CAHIhABQX3K1KY6 9aloy6U3OcAAdBLvoQ0oJ0m3ytXiFaEYEQhPm0YggbKaM570hMtQh/oDtrZ1igJDa1fPd5ErQq9V CsyqSufgwbn6VXpylevZFiABiDjgAuWAgAZIoIEMkMADoIkBaHAgWdAY9TgMTapkcWBU9KCNs0dV QYNGO4LRmnYEZLVAUj06Wc+6NqMgU2Ad/CjROOjShNIbAZj6OtIRmHA+/LSnUY6Jnnj+80W8+KYE QoA8AWAgAxp4wWJJQAIEQPYHLPjBBWKQEBCEQBo3GEYIKCABEVR2cZUK/9hXxpKBDDSgvfKQR3st 5oJcXCAEIDgqXMraWS7KS6vzjK03R8CBvUJMi2DcXt6MhtvimZWfUJQXb0UotXScDS448Kh5TeYS F2QgHqqRUgCkazENmPixHhhAMqgUAASQYAMu0MADTkyCBITgBzGIQXcSJKYQhEBIJnavZYZMZMsw xsZI/YFSyxq17EzYnMu6Ylh12SvkKbDBIQXNCBZIgRGobQVkDSu02lcNZMgEzClxATOmwiGeaZcb CQJofVfQYIbxyL8/kEmfJMAA71alG1WZgHMPoIFzUNdPGiDaBhDwgw1sIBMEIIECWvAAEhAAAYV+ AAE0AIK0YAKgWhRAeP8bq4DEFUABmgmLAHSigEArIAMBUEDeXhCBOIe1wN8izTQALDD+SkDAz5Ma FCGQt1s4IAO6dAB/VfDPE4CTB3aCy27GEgERaCgAAjAhiypB1aQ0YAUSAAmrgBK1CUiAELtwgQSs ISb+zkddLFJGt9fxAxJcIMUaoMEGoiSA0NxgA+chwQ/Cq4BEh7cGo6MBDc5hAAjcYAYPyIACSBDr Dczg0iFIRQOGPQcBlKAAMjhABmQwg7MJAAIKmJrAOgfrhhegBHGpKjF8cQcSsaqs/pSABXxd1hGQ Ann0JavPv/kDJtu1AWUVAeBQ26D5oLaY9yDE7mRMAhZIQgLpqAxSgPv/63O/oLDmTgDSoYh1ZW/c 1+ko+7FM17IWkCCsKkZACm7wFwMs2sQboAEJSj5w0+h9UhDIuznqfYAbINsA+f6BBiDQ3gy84Dye 4YUBsnEAGmgABlKqgDkUgPIDNAAF2Gh4ACpwDZe34DMkEDmtdgCtOHiU57Dnb0SyatmyOoMD/I1K UALwbQcwVGwhQIADVkDrvW/bEownAcobgIEHeKDSw137LmL1NXN3nezz8br2085FtJM3HSewcL83 kAJ7O8ADix4AAmaQgRZkAAGOrbwH9L3vH6Sg3j94taMJYYAM/GDTEzADJEADP5ABltFe55EJcgN6 JPAAN1APClEBGXAA/5xXahkAegEgeiWgARkIHATwFDXgf0EzIyuQDaQhAWwVezw3AjvDc7f3YCb2 Aw9wY2cDAgjgYpngXj+AAdimeTIyA4ZHA9ald893Y5xRIMO3JJZACMWQVdlHdmTHGLSCdgnQCeRV AIsVgjLoYyEQIhsQAhpQABlAAEZRcg+gdwRAA2Nofw+AAAVwaRswY5dXD5umAZE2epNycqrxAwJw ABVQcARAAClggacXaxM4FRYoA1KCAlKiAMDRf7E2eA1QaignAJqhAJyXC1/jZTxQdCpYVbjna85A AScQA8VwYhsAAt6lCxdwAYwlX0ImADKAasiGASiwaQ1oXZX2fAgwAP+WB4byYQFfpAq5lH1CIgFj 8WsscnZmVQkrIAAbNwOJZofh5QFc2IABIIf5VwJtqBAaMAEVcANtmAIRdwAPoH4Lt3f1UAOMVQPw hwE72AtCNnqg4VhjWAICUF0zsAHAsSlTgQFVwYgTgAIQYGkz0G8T+Fw/MAMQgAFiGDYQ4HGN5150 JhFkFXtRQV4ScAIcSQsA9QMhQF0kkAE04AEeMJKM11jy9V7x9V6NlXyMdYMmOZM0OZPjpU+gUT0m dVSTJVllxZERIDUtkgP/xACIlQnVxWg/AALqhwAmZI2gYZIXYIAa4GIn6WIN8Fgj6QGLpwEewJSg gWkT8H4uRl2RNw//88AajiWSJ+ZiQZaDQsZ4B6I3KpmDB5hcL7kmoJEJ8nCATKGCmoJ78lJak4gH rshYsDZxGpCVN8iWjfde8JWDVekBNyiTA2CS1jUAmjmT1eVj0HIBIIAIkzBanqhUCbAWx6ALZFGQ J+l/3iWVTxlWX+ld71VdV8lY1UUCveCWnZlnjMV4N9hYixd57hVivcBYJjZdjimZBvheB2KA8phc Bkhk7/eNvVACk1dkQ4Za3MmdBSYv4bGYE6AAG9BY0GWAFJgJk6liP0CZr/icQVabKcabvXiZ9bmZ KTafbbmYkmlfwDIWLGNX1EWZi/WVP3ZjWRkHD5Ff6vd+P4AAB0IC/zEGneeZATR5AYvHeO2VnJF3 IETWC8m5WMk5nUYmZGnpoXDZoUNmj5axIdppGT/AkR+lZCkBAV34AlSZf2PZXi1qFAV5mQKzmW7Z eCGamUJalVGZYkKqmeqXnLwAXSKag32pHtpZoCM5maDhY/UmXY1lQvkVBzeoWNaFoSSqQEiaoU96 g9C5oh+ag9SVnCc6ASNaZGnpXiTQAG+ZkiE6nSH2ojY6WqRwAcZwAElJlRNQArw3nSY2eiCqAcDw AyqmmcMnkmxZoNcFqZQJWUyKnyapfOqxWI05kd6knXKalMJpXZCVX+25mLipqj8GFEiKmXqjS9UV AYtlgNDFGoolnP9rKp16yqtpWZWICZ8nKg8TUJYhGmRRuqvTqaJbAV0rMKLQhYvKB12Qd4CNda1D dgED8HaYqZwR0JgiqaSYaqRCWl2flHxuaZ5bwXhUmlxbAapv+n40uZRZal3Cd6lsZpIOgGkn6qvQ NZOKR50n9pKWMZZvKpnK+qsmFl+72rCM15pXWl1Bhqt56qeNmpzUtQEFkJvOqa1xqa1DhmLRpaSq aAwoVpYIgF/l+pWXiZLUOawqpVjIBq9DNgGmGpM1eV1MeZmZmqVRYV0+ppsHK48bSl0R0IU2q6Hr QWSLdYDuVbH8CZ/TebTmeau5ipjtlbE3+6JyamKKRaCTCX9+WrawB4i0JsSeA/BjkGqfjIVbPmuN ixeXiqW1HkqlW7uizfp+SWmbNOliIaBiDBq3PuaK1tiKQJGWRvumJpa0D/qeXdu1BguZRFqhxSql KMqjH+pNeTuqRSaniiVdmPZYOGi2pguvEcSebbup9RaDa+ti8OWcYbuua4qr7wqXuEpdMlmZlal8 SQmVAgNZ9+UAYYW4TOusBihw7cmFuxC5K8quE0mkDfuvcEm9pkult6udQQAAIfkEBQAAPwAsAQAB ANoAJgAABv/Aj3BILBqPyKRyyWw6n9CodEqtDhcqq3bL7Xq/4CPHwRDiKIuwes1uu5uJQ2E+waku ZWdgznlH912ATy4FDm8cF0MuQoSGYT+QkT85EQIHCQ4TAg0MF3iSoJIOAhMOoaeoqaqrkQkurLA/ AQKxkA4uDLW6khwCrz+atri7xJG5AgkqkBMNFBcJshPQPwwuHA0BDdQQAgHQDBABpT84DdoBPw4R PwcQFw4XLhey2pAU0Q5nFxOypj/zB9o5GMgBUgQI8CaseBEAQsExuaoVlHTgx4qBBwTggBQuwDoG E6RdgLDOAYQEDBIk2PdjmIMGBwJwcOFgTM107FoO7BTAG7X/H7QaxPHF4OVKCA0ihLyAo2YCcTMj DOy4rhYDWg5yRMoBD2gDTfUEFPgqwOGsAw0WzJJFa96cAA5WQFp7YYVYSGUjCWAoIMI8WkAnkgIq DdMkoO8EALaUzhOPUQVkAesGdMVfZXtcaLKsKRxgF3sd7MmmOFewHwV8eXrHIDK/vSNJgf1boKHi ABS0vXCQ8QeE1Ii4ZUs9wa1mX7Fw9PqnYsGPBYgalN3BlkElCD9UUB71qxsH7QEuZDSlYpYy6UXL ckhAWfqrXH435WCPXeyKBC8mQiooQKslT73B884o4eHR1lXYrZUdA9WUhccebbUkgGW9XTCLP//U tclqA9Hi/1BBufzAQ05/ucAVUM5hN1dfF0j3TwEVWUTKBfaNYRWNP6zEwQ7vJMDPCxTk8IIA8fwQ FjqjvJAOLYpZQoGCDGTUpAAdKmlKACBRuV8Cdk2JTgSp0fILJOIthuVQ6ayk0l4qjcIkZQq+kFpv CTijGAW5DOlJYNBoyQ4Fa54EqClH3vMmLekpaUFvkURgwSwMDrkmOktOwAE3ih1QFSsqiPbDC3hQ 8B8/ECjDzQVDHrmkkqLihmoCjwJ2DAU2IbLXT/9oMo9FEfyCJ4bpcBMZJCr0iVcAOxjrQALrDfmC SqJKQ0EEHHDQW7RLCvWUYioOWVNGK3kLFDX4kYKSYdOaQ/+KBbQos0IEOyQpyXmf9mnBp8iwR+k6 2EXgl5zDrrKDM12ik5oLCVQyoV3epHrsqpBkRFYpUJ4zZF9AKQnUJQnAmEmEm2iiJIxc3gVJSoxS huayDFDgrErshAwMmqIeINpe10hmEb4YMisuOi80QBwemIxyQNC0bHtfTqOMUxG1L1dU55A5ityx kUAlHRAsPDjDJV5Sq/SKWBAAqrEy292aY0UObnuyj3OSQaPGliSAw1Ca2tKbTD9QIOUlxqAJFDor o4SDktr2zTYEDCoo3VgxoVbAM4px8PM/PP8QwSzdkIKnYZXM5ZdJmVY1y4936hllvi4eJRY6nPTZ zT2wdKr/kkoF8YCIShdQoExKvId4ynr5kMvU28CeArMkDOj3A/G8MBvJ3XYzb1iaEak5Dcur4NC8 KNIHnjxSfUtnaUr+LB/KM8KTA7P3zi8LYgJCPa9NYSopU4sFgN5ekwWd4J0FqHOH4I1oeOFLE+3Q twr1kSmB0IvEeuJXp+k9YyLcS9PyMpiKYiUjEoByHgMlwY+YKCYCKhihA6N3PHsYxoP665v0UrKx rNVkDBW80e14570dOuAe62lT+0AxwUh4MHtFG8hAQLHCINKqf+0rohF5xwGv7Qp7xLqdLVaiRIKE Yll1wuEHxcdEF7zgBSSZhwqncYpnhNGN+gMjrcD4O0y4/2wCKsoiG1kRwB3WyXY75AAO3Ii7VACK di5Uox+1KIkVyjCQoDgkKPrYpo08UHj9e+AiETk9MAZvkith4jSecY+U7MqRndzhJyDRFFWGyJQy 5OQ/UBILSt7Od540DPB8WIxeMo9Bu0ghAyzpS1VIgEEnKGYxvMeAGEqCmc5U5ikKqMog3u4Tu6yk NLfJTV+KABJa+SYkJCDObprTnEVZZC5y6QBlWLOQ54ynPEEhzhyMQALOGacE5snPXr7zdrkg5Eqa KVAd9fOg2xTCNSCgAaQkAAQIjagxJUDRdC6SAyMo6AX+CS2KevSjIA2pSEdK0pKadKT3koQFKAqK E4jgA/+z5BIEAvKAFDzgABtAwAD0ea9yPmecP/1BSvW5TwkM9XnVAlFSl5qLEcTipCa1qP8kMIJF brSgdSqpBikA1a6ylAPHTIBXj8kACaDko0IF6snc6NQRZGIOGEDBAR4QgA2kYAMbIEEHPLDTETxE Ax4AgUo0QAAEvAABGNpnDPrYvhDAJAAB6UlAJtsTcTBDAwiAxDf3qc/eURWsYz1mLnlHLj86wK+m LStJ4VFFZpH0B/ccqzOoylWvnvWsHkXFQOGxOTnM4XUb6MkE8LqBDnTgBwNwhiQ6QIIMbIAGE3iA XTMQiWRiomX+ooBJ6krXycJosuD1bWQzQAEWhIIDZfX/bGj7t0mO/uqir8VtLiTgDH888bQS2OgP KYoIU4h2o2atUyckUEXtljUdBPHoeojmjNoiggIUAEEIILGBCWggA3MoQAUqUINZEOCuBGCHXdkB gB94gATNDQANNjCDGvwAADQgQQA+/IMNhACmiCCXbxVQA+keAAMKUIBiUCMlIAsAA5YoAAZmgQF+ SOW0fUMvtC5wz5qMlHnqSJi/IoCSEXgNjM1z45aplQoaRq/B6XjFAUIQYHXAZ1mmWMkF1nFBDqxj WsuaxzPUgUg7m2J0EWhmnTZQYxJAAgEpSEFqlPwDAoSYwjQgwAFqQGgCRHrFD3hAalDzgxqsmNI0 uMED/1xMgh+abQ9zKIEMbgCD2iig0xXAAJAjUwIBVOAHGGCHhveAmhnMICAuCEHvMsrgEWyKpZwd gbKdWsU5+2VPzKblsvu35ZU4tW+fqFYIAi28HxZEKj9QgF0zSy1jt1a71IqAshngZSrb2csJaLe5 q0qBZc+73IHmgFw6nYIMGHoAHrABARRQABQ8gAR3tekGHH0ASdOgpjSYQQFsmhEULHwGkK3xAwhw U8j2JNwZnoPkOP6AXx+gBL1RsiVkIPJUywE1uVYypb/kgntoN8dUHYEK7M1zZVdLevZeD7uX/YwD aAATBdnnCDJLggnUlbAxQUpdfpCCAPz61h1IgU5J8P/tltUJwu8eAbud4Vd1k53s5R72svGdiwSE 4DcPgIQGNGBoEnjgBx0gQAAoTQK8/uABWU/0igEg3RAHIAUA0EBFGv73hm9g4941oeQ0XIBWpwAS BTCAYhTAa5WfvOUC4HxkCkADoMzgBzTwNKUy8IIMNEAu1052z5f9j6Ev285DBwUAIArOBUzYBhuA EWRfXQAFYODlBWgB6gGPgJz+wO4D2IAGQggPek9LhtUyO5XJrqMI1Hvt9e4yP2AcfK0jAAEaeAAA PICAmER60iV+gAYe/lwAIJwEr0a4/TMwA0f/3aYpUHq2dnwBERlIZgB/h3qQsGQdVgAYV3yepwAB UWv/BeBptKBiqEEAN/BjvyZrd3ED4gABNMEAOSBOs+dUeMBzQvcDJ8ABGoBXAGADAOcB5oBiVRdZ kHUAM6AAM0ADe2AAJfB3GwAAHYAAAIAAHVBiL5YBCOBGZWVnfxRE71Z9yrVL93ACVZYw7ZABH3Zi G5dZ7Hd3iXZh6vcDykcCD+CDFfFhJAAAAHAAN3B5VFdpBeBoiUYAMlYBCCh8ciAAKIACClBTmWZ8 l8dxByBXxcc2JzeBBUBoNYABBhAAN2AADSeBtTYLBoABxQcDAUEDAcFQA3WCKZF7+4EduYBoifZ4 xlV1pCdZMfGK4OWKdkVoP4CEeFeExmVc5/cPZKAV/7gSChLAe32TXs6jFHMwhCSAAHz1fCgGhgOw Uz+geAWgflrnbylwAFp3jQgAWQ+gU7WIAE1XGyVGXCEHXhmGU3Z1V9LVho9XgJLFhwUYE5D1FnJQ gDBCVyEna+H1XQ0hirR0Mr4BgnOXirxWY9iIYhqQaN2VgzlIWcn4YiV2XLWIdyYACbmYAnaHABkA AXYnbJgQAs5jCxDgdBCwkeGwaCmQdQGgU5kVjcmIAByJXAOwjQfZfAhnV303BzdJaB5wYhowATDi hnSFaudoj3OAU5mWaYm2lN1VG664B6/Ih/RYj2+Rk3NQASggFvW4j6gwipozknvQg8EVADe1aQEx Af8P2ZPP94KUVVkxkZLPd1d59QMm0JImUJG2iIR9V1OE51visAEZoAEhEAIm4Vth8lvYGIOEl1Mz CQHKeJAxoVM7JWMTGRDB1ZR11RO7+HwTUI89gVeaVpRGeY/BZVfS1V2GCYv2GI/zCCPl+JZEGXKi WYCRsE/fJAI0JGM0MI0AYHKtKQclMAcaAAl8dZcVeZOVJV14ZWiS0Hcm5gHGRZcm0AE2AAkmsJcb IAefeVeRVYBi4ZrlWFNZN1dE2JPn5wFVh1cBQALPeGIHgGK1kYwytpUhxw8I0Jl+6YaoJl6tKZsB AADqeFP2SFwNGV6veI1NeY9J6YqjeZTeRTshwCX/K+ACDaB+9rcH2UlkUEmWoxcTG8CRO3V31zkB qTiLFaZ1MnmXx7VXoECdxpWdR7mcCOdxhimb4DmNlwcAY6lXezWDBpkCE5AB7ekBGTAayViEJFCj IUdoBFobZQkj6tkTsumOC8qgTJqdOBiPBbiT6tldoElTTzqbRxkS0dVxTIp4MfEAAhCcnklXtuaa 9Whod4V3fVeiNohXKIpcE9mSFkl1MpZhdQWgjzeP9GmjGWZXgkpXt3hcPWmeE/lv5gkj54di+Dml teF8tRh85fh4waWkOGVT3yVdbllX6omlkZVp87iS6TlXiDeo2omqSvpd/Pl4ShmAIdaGMZEabFob /771prJ6jJkVXC35jD9pfgiHkZI5nZCwU4gWm9rZjjVqCTDqoDWao0MYd8ZlAzbAqAAXCeCojOb5 nt+oaEZ5ADTgg3Z1YeAoXm+Rg4ZqV7GYpvLIn5j5mUNZU25Jcbk6V8FlqO/qYysphHr1p0fpr68Z iylwYXYnk7XIhBXJXHcFWAMwncfVfN05B4LIoOfYnw7qmv/phlRHhNSJhADAhM8JjZHQkwg3qRrg rtSaaGQJmJPKnedosFLalpWVs+Lll1QJi+DpqVJqo1S5pE6JluOGcDubmkJroKu5nh5gAs9YkZGA lzY1AZkFjgDwlHIAeAiHqoDaoPD4lkNIpygGCTB9h1PNqIzPyKyY1Xco9qdB+7OThVl3Z56mGqvC 53FhW1nquY9OaaAG+12Be6NzEAQAIfkEBSwBPwAsAQABANoAJgAABv9AnXBILBqPyKRyyWw6n9Co dEqtWq/YrHbL7TIpF4Z3TC6bz9IIpsc+4KQFNgUdjWvtT0jvgqZEhhBCenxeH4aHhhc9AhEXBz0B iJKTiT0HFyqUmpucnZouEJ6iH3GjiRAcpqqIFD2hH4+nqau0h4+zsJEfKhAFBy6GHBAUAQUBKhyP BcAfvZeGLtEFFx8UBwUQmcLExpm7xc+GztQfyQUFDZOg4hcNvhSS2wcH4r7kpbvX6OLZvOkXqD5E izAvwiEX7yCQO+TIl0FDEc4xU+biwhpUAFMNLHjw3QRq5vap6lFAkwBIjyIpMhDg0QEKJzEEWJDy JLwCBgwUcOBgUQD/Sx9WtgSqAoMBCCdT1ewBT8DRRxMWLDiEr4eBAz8xSFopINLSmz0M4YTwCJge CD/TDSJlQAAEAz1S6TEG91Wwtkj3fGhg6VG6mAFcwN05QS9Ot3DlkgxQ94NTsq5GlpwUITKpuIro qSAZtEdUDpB2AY1D7lGmnxwyiy7pogcwDg04gI60mZ7VBg6oSaUa9kMPrY57M+RcLnTty4aQCbPs lPjaOKl+UsMAnK/dzgJc8DSEQYAhAVoVvSq1oDA16B+kf6D+YYF13wZwL5wktX79tvYjcCjfI4HU wgkk4JlUiywgYFQCssGGAAucVN9JCvZ3IIEMAmhfggoyKBgbGLhg/1+DPVAolYMXDmhghAWSOAFc a0R1Ylz/9QdijP4VeKKL9f20oAMLoBjihDPy55+KMto44Ya/efjhkvY94t8CPWHgnmtS3QJkgRP2 NJOBI4YoVRwqLCDbjSLyFYGYsWkp1ZOyJbCiAR+SaCOJ9QGpJpcz9lSACkA+YgmNQVqI3wKt4SiV AxxE8FMBCwzqQJhAEjmkl4IySOiAbb7J5AI5dOpppxzkFABjPUSQAwM5RaCHADkc2OkirXrWqVMR FDZBDid5WtkBCRjFgKs5wBqqAAnEkQCuBtTqGaoYRKAGBp/i2sOrrEobLbDIKntrrj0Re9Ktu8Zh KoDW5kDuTxOoIf+rpwIS+4IlOfwEQWWsCljAsSfpR26u5vYXr2fqTsCss9RFa7DBHMSxiKmdOhDH VQzEemuw9a7rAIQBzDqtpyv+5oDE1HaqLgYvNIyxyTtGyy+s5bK7bg4Xs5FxuT+x1B2qBjCAMwP7 bkwuA49c9XKnL6xhScRALxixtAXkEAFcDvTc6c9BQwUzhAJ8fPDWXHft9ddghy322GSXbfALDFcG gdls54C2yK60LffcdNdt99yFCeBUzneDnffeS4O9w+CEF2744YgnrvjijDfu+OOQR/541BO8wIDk mCNOueWR8+D556CHLvropJdu+umop6766qy37vrrsMcu++y01w7/uwUWiKC77rhbcILtwAcv/PDE Fw+67jnsbgELLEgggvHQp47D9NRXb/312Gev/fbcd+/99+BXvwMOun/AwggSSCXCCRJIEP778Mcv //z012+//CrwcIgQUQewQQATcEEIJIC+7XkOfirAgad24LkdfEp3n7sf9tpHwQpa8IIYzKAGN8jB Dnrwg+6rHgVPQMISikAHI4iAC1bQgANQhwA0IMAMaICAAbAgBu2zQAyeh4P2LSAEHHDeAk4QAwu0 LwY9vKAFFqACClCAA09kABSdSMUQMGAEJ9jd9EpYwiSC8ItgDKMYxwhG3FGwdxbggRF1BwIE4IQN BmgBAWpAgAfQ/4AGAOhAB0xwPhzEQAUO8AALRGABDTwAABMgQQLSh0M/to99FujUCUMQAAW0oAUK uMENFMBJS2ryHFiBAAlCkIMFeJGMqExlB0eAPlWi0gJ+1F0MTsAAFTDAAjoAQQYEoAAU5AQFM7jB HOl4RxrYwAYmGAAIYrCAC+BxAB6YwB0JAMMHTOBjJXTfCUGwggtcoBjUrIECSlCCCpQABueEgQxg oE4UmFMBBfjIIHlHQFfaE5XJq+c9xUhEmIEgBCHwgAb8hxQUoIANLagBDOoYwzkSIAXUtAECPEBR DcCQBjOoIwAekIIa3AAA1AyBDkQggU4xYAVOQUEJagDRFlSgAv/jJOdLqfPSmsoAAxWYgQEwcIAG XCAELMjBGFlJ1KIa9ahYHAEI2oe+o6pABetLYxodKAFY9nB3IoDZASbQPBwU9alIDatYx8pKFehQ BCDQQAFokIIODKADCACAAqzSAwVUk5gPoCYML0qDBxwgBXK1CjCpGcMY1iCvLEXABc43gRtUwCoG kIECYNCCG8wgmOUspzlLME6bjrMGJcgJDGqw1QRYMYcUHIERCUjW1iKVAexDqggukIArOhEE/2QA D4SaxtSEIAEHqAAeBakCoj61uK5NrlFJOAIGpI8CE6CmHVOQTBOYgAYyMAAK8DjdFExTr2y1Yy83 ahQZ0KAGM6j/QQ0MwFZqWjaT55irL38pgx7UAKTqxSQnM9tJzb6Uky/NSQt8WYO+pkADF6hqDnK3 vhMoN7nOMxcCiioBWsYVAAfoSgoCoLcDRIACDjDkHBVggAd0wAZuZYEtGXA+Bz/4wSogYQ5AQJYH bAAAG9iABvS4xw5gtI7ePe8DjgkA7w55AzFUwAwAYIMNOMWuMZxhey0JAwNkcr45yQkn+3oDLCe0 BZq1ZExzUoEbgLYC7KVBD0YrRxrcoCsBEGVFOKBaI744rGglgQZo0AEQoM+BC/AAAABAA5XOYL/v 5CQGLtmCJZtg0HocwABMQIIMDPDOyXXgjF9w4xQ8oAAICDUC/3LcAYpi1LAE2OgDVr1qwNpg0BVI dQpsQIINKLTAqSY0DdAsWgXg1MsXfcBcb5Dk/CrgpSVo9AwwWVdqkpjYMqgAehWwThj40p3pJUAo TZs8Oyv3BEYkIQU2QM08QtMDo9KAd2uAASUf2pLZ1mldi4nMY/KYxxsgwTKf19SyHhe5rXWwBJh3 gQkEYLp69C6KEUAChoua3ACoLEf7Kk7hFvmYlkSxRElAaBRI19MAWG9OZFCCGRil133F4w3YS2gC 3ICzhw7tODO5yTQTAM01aEEP5EhtQ4e2AjKQrCX1e4AMaKC2rs2ms5xLAjuuOo82eEANUJDQTWZS yZ3kpHoX3f/XXEP9mPbW4zE9EIHa5mAHtsRdKXlAxD/6mYRVbV8OmpeDEGQguNsdNAk8IOkipwAB EpU0AjqQggHXcciHFPaQadCCkMuAADaQNMch2oMl65oGWUbBzKss4GLmFYYbpSaYc3poczqWkwZY 6SYJHFoY9LIHJXD5tWtKzv2igLIzOEBrJWBFDkyAjjnu+g0WTWgFHDIFns7roQ/daEyWYNH3fTVg 82iCDkDauic+JkcZPoGie8AP3XxiEAkogh1wIAEsBOCoIAQDxH90ACTQ4wZcHYC2vhUBhz6kDfAY w0Ni3gCeBnqDF3pWNmjoJXK+BFMAlhNr1lDSxWrnNQPllFD/MwBTK6dkJQB7L6ddMxB0t2dQS0YA ZPZS7lROJFcCJBd0zXVFR3UCHPACB0AAvERHMkRHJAZT5PRQKMZjRUYAnWRmHqVkfEZ4xUR9cbVH 1mVvKNZy7WUUgxVKAPVNAgBTBwVZa7ZqrwZDNUQCATB4xpcCCiAAACBpJtBRgwYAMEUDBeByoUVH wRR2EEVt7qZXmcdZMsWAjzdHXede5JRlWGeH/1UCKnUDLWAA5vRLKBB0N/AAjlUBJYhmtIeC1IEC DQZuyjMCIaABOedxHUWIy2ZQnIVmKPAAJoBi1oV9nuZmZrZXeISEA2AD3pVHPHaK9mZdEEVNaJZe 07ROmIRT/4JlbTKQiAawUIgnR7OmR6HmAYwIQzOQApJmfQqAfAYQfXG4WXCRE7lGAOfkS5ZXA2im WcmWXVjGgaumVzHlS3r1cuS0jjGVf3a1iVamV3MkgZyVXVmGbOtoAA4ARBSgARDwjxMAWIDljXNU ey61Uj5oUKOlbRqAfZOGYat2R3YkXSg2aUnIZD2GhCemR7tmFbHHVhuVc+KUZZknWgZlAKDnXQkl i27lARxpfAVgYsgodTJwX0wGizcIWQzIfzA0dRkVWg04TFOXZT0gAwOWUeE0bUCXajEEZgqgXp2l gAawUQ5IRzl3Rwq1UARQiPe4jsHYbDE4RwllRwZWcgSgUv/jZGjoRYJVFloYQF12dGIgFZFslYp9 hUzV9Wp4eZEcVQOQNUNBNmLC6HqZd20G1QMaNZFLFnal5pJxJX33RgKRBQAIgHwEgAHllGXrhALE NnhwdZYGZVB21ZMDpl2+1ALTlIht5lHsRoMO1UkYQIMVdwNRR2xtNpGrh5QKdZKGuFnZVZRWSViF NWjC5lipN04GsHru5IiJyE4GRUM+Bmp79FYbEJNE1mo1dJGRhgCMaIgKOY1NCZQMCAOMB1nrFIzz dXxd93U72JKTJpeeyXAKkEeh9gC9yWujhV6H14UpYBTm5EuEyE6FmRN3xI6YREcJVXEWyIakh2vq VUeaBFr/Tdlow9iTvImIy+mIKFlgNRlXoPdqFQiK8xVgCeiIQXei6rSID1B/rmgCCEBDqBhDG6CR ekQC2thoJlhHMvRyyNkDt5dzJKl5A1ZfS8ZRG3WT9uZdCFB9fJdMPBZqCkcCKbABw3dsonVJFEdY DBd6LoVs43iSKLCWnHVJl6Ve6TVtOcFZhlhxx1ZyYGaIhsh5WTZaOnWNv2SCNYWOG5pqdfRqD/Bz 62hQ5lRThBpt+KhOaVoAbWVdFnmK1hV6BFBDcZUC75VJRgF5LedyongDhImhMLBJLUBZdzRor3aG g0YDGFCXoeZWz1hrUlqXKeAUmvRL1hZZlNV+gydqL4qZJ+hkmCdZk+LUZUrGaMGEa4dGHZmZnJu0 jjKloRiqUqFFks+KnqEZBAAh+QQF9AE/ACwJAAMAygANAAAG/0CdcEgsGo/IpHLJbDqf0Kh0ShVC DL0sRFjoCXuFZFcZoVAvvW1V58L0MBEhxY0x63Bdg2t47R1wRgFZPXpiXlFgSRA9F2tFH5CRkRN+ FxECPREfXZATLpKgnKCRDYyjp6ccExeoraAUPQITBgYqKrSztZs9AZisLn4HPROgwAeWtCqooq6j YK2UrM3T0wYYkRwFn6KepAXakKINE8qQ2ZUfKhMFB5+g3R8XExyq0hQHBeQfDe4Nmh8T/kGKUIBV tAg9GuzLpMLPB1gBNl0DKG3SMEjyOEBq8M1dl3sHBBIEh/FAyGcZP9QDaOrDSHfUYqIhNkrUsw/C AnTZ1gNnD/+YCxy4EfAJU4CcoQxAOlBr5sNYgg7gVMrhzVOYoXqoMzXT6YdnsfApBFX1TchIOYXx zIdFWSmTCeO9meCmAEtWTqMteCts7KkFC2JG8poV0rOqBwBPcLBLrSTFphDS7KIxErAIDaU6FaZM EAeEDtr04FCqHChhxKLJXXXxq90sGNxEBHVpkACVDgEypnz3A4bbHwRcE6axql3VeXskWPAbkvBW gKEDng7YAS/qLlQswAQ41oIEw6hvHxRB/AJKy9FDXk7dQIFSDr6HxzRI+QIDHA9g4FjA/IKc68k3 AXgTdCfAAm8AhoEB/i3AgQuYuECgeNydZ199WYw3nXfqTaj/HoY9NCjiiArWAthbGiJ4oHUBKBZf hLFpR516pbgAGHHiBWCAcIBN2IV29NwogAER6PSTeYLYCBhCDezFEBhBXSfAgSlO51mPw7DoYorq 7Viddj8u0NCBHYbXJZUOyEiifzm06aabCGEwgTAGcJADJm3G0uaQEVAywZ095EDgmzn46QADtESw iACE5mCdARC0OShCBySwIAM5IBQoeD1g+iZ4O055KC60YGoUJgnk8AIYghRA6KoCRFBbqnz6CWib 6OUgCAQIMYpQAQl0weiqlWLyZ6679qqqAA7oyuidATQqbaMJ0FdAs7fmoKejmBgQbbYF1PkmB25E 6kAeB3hKgigmdgo6DK5YYIBtDu61WS+hXdSXqlBvYMtAty+4OQsY6ropyCDfOtDtt3gWqlwODAgT i6d9FDAlxHnYmmvEWQiAaa4NbzvtyCSXbPLJKKes8sojM5BAAgWzLPPMNNds880456zzzirv4PPP QAct9NBEF2300UgnrfTSTDft9NNIBwEAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/adsystem/graphics/1147972349705/pnas/pnasad_etocs.gif?ad=10482&adview=true R0lGODlhdAEoAMQAADMAAN7e3pqFhWFhYWE7O7yysj4+PoODgzMzM452drCjo9PPz0oeHmxKSpmZ mWxsbHdZWcfHxz4PD1VVVaWUlHd3d66urry8vINoaI6OjtPT00pKSqWlpVUsLMfAwAAAACH5BAQU AP8ALAAAAAB0ASgAAAX/YCCOZGmeaKqubOu+cCzPdG3feK7vfO//wKBwSCwaj8ikcslsOp/QqHRK rVqv2Kx2y+16v1uLeEwGm8/oNNCibrvfcBg7Tq/b03Otp7QfLlYLf3eDhHIqCQQQBScefS4FfwsM ewQEFJMpBAojFARAlgGaK6KFpaYneSYYEAoUAicJCTCkrwqeAa+ZmyK2QBR/pLqnw8OpJQCCnA0Q HgUMDLIiAgoQEJEJDa8CEh0UARgBEBIEC+ABiAl/BcsduwEKHRANixAiBbkB5QSvC7EEBYgWecCQ 6I+ARaQK1CvgyUODUNgaqJO36R62RcQynjE2ohcJDwz6PYxFIkG7BrIg/8jKFmoXgHe3Xgp4iDIA AwUg3SlgQIGChAANvKkcoVLSIgCxJFBA9E7AgqGigr1MIKEAhYeVFNRkUKDATwVKsTW5sCTDAAd0 LGTIIEJDhI0oeiUAMJWVgqnRRJAk+TPA1ZYiXnp8iVJBwA4ignnUJKAeJhESFFCTJdiTR4AEZEV1 18BWrASvRMUq0A6eZMu3hmioMGDCg7cVEKBFUmHtBBgHBugeUIGNhQcDyIr4PeAAiQocSnDQPYFt CQ1mB2x4wFE5ggEiNiB4iwP4bubOe1QP4AFx4HOZ9+Y9J4vkS5iAA1Q+nyjWtFuK8UOqaj7w503z 9dLJZIAFE0sH6xBAyf8msez0mQe9eDTEAA+IsFYAGRgwHhAXILChChMgEIAGDyCQXAQIGCBcABFs QAKKFZBgAQJkaeAiCRpMMIAGIsQ2WwrXifDABjx2R1YGHmIYHg8b7nMeQyL8QdII6gHFoGYuwScf e1FK8kc7HXWwgAd9EVDTCJ3lc16EnoCCAZbxBeAVOB0wkNiVNkUCn4RBdGjciMmVlaQMA4gYwIwV BoBAikUGgN0ISCLQaIlF/ihCodyNaMB2KgTZg3NIsqGBpTtsuAABEkhQD3o1XZJXlQlac85NWw6W DwRmbrLNON6IQEGdEuQylyNyNpDIHgF68mtm9YiCwUMjKBXOqqLJ0sn/MnumFgSKBoSnAQcZzMYB cBmoFYEDB1xgVqCQVoDWWsZxcEBvvDUawAWF1jaiWdQNtxa+KzpqKKKXxjZBkY8WLNsIsQ2Q6Qgd 3jhCiRl8G+5y4QV5broWO4DxCNANUHEJFlTQL6SDHkpuoxHkVgGP/D6cwodeeKCtRj0uukFy0CHA FgceRsxBBCU+kCGnIwDNlgZBAt1tibeNEEFsGVyQY4VIJgf0BptaWqiQJl6aIwJRJ2zBAUAneu+m CLxMApIJW3hdz82FOJvGJVpAdwZ2j9icBgbE7QCRoaI8hwM0Ah41B0RG4DDfATiw5Mxu2IwRzm+z zdaMbH0tsNxsFD4C/+cieOppoQEXnjWLZJd+W8ACV7DBAOxiB3jbjjJM1qaZ4ruoAY3CXYLwpJOu 6KOFF+8zhggckIF2JBjQHNWGiyB9zsltsOQABqAFOwo0d0Es5iAjacChy8fGxuygM5+K8aYjn7L7 As+xaOlxj+B5CY9esGlubQmcdJYnoxCFx2nDax76NkdATyVveaQrlBhI1jYLyOyB8qsaAUUANARs 4HuoIF8dMpCpEC1wRA+Q3gOKpLr5we9RDpTU25JUokB5EH8n2B8JEoY4B8boXjcMwJ8CoDSQbSpg IXqL8pwTQ99AcHkl+l6H1DZDNnQoakhyQIfiFoGpBXEF4RNhCZJhBf8HJGwDMSoeGifYPtENBwEV 2iIOAzCBIbYPcTFCERPzdylD4ShqIjiAp3Y2ghCt73BIEwHizEbAJc7xgQxkC+ImEAHokEA7m8uD 6LQDG+AFAJMaEMONJiAxFYRRCJBoQSqXEJVeUaFFInvAColGNgt08HccsECIXrPLh4XIZ2RDy6Iq oK8CwpENgszNCoWYoskJ8phSK1EFMgUcWk7zUNrZgFoM4DxCKmcD2jvABAJFS0pC7WwpcoAu4VjO ciJTZwG7gHYUaKFNTcB7G2iOAQIlz2GSSGTeBOMTgqECgiJBFL/AQgT0hgKjWWCRLQilzK7DUBYs VGY30AAITWCBjYr/4KJACCUKLoBRjnKEpBCrKAvG049O9AodC1CInBoCLb1kJh/YyAUG1iGLbXQD PenABTWs4VNXKgQl9dAKBvpwFWYUCxQdacBScerSEojiIC2FKkyvEBv92TEGnhIjGjaEFJ/ggiaU OUdV/iKNzmxiKCxJxE4Qoiu0nuMkcIpWAe5SAJDE1E5+FYsEPDCmEfjVGf4xKwk2I58EmHUmQFnP FJDEFnzZCwZbO6VYq0DW8xSGKZ1JD2jQ5Mq+/IWxovisJ6pEUGQsAC8iQFAC7PISBmAgoXqJBoK2 tCUBJGATjH0PYX7LlCs4YGU1KMNmzdDZLdVntAdKkCOkwos2Afe616FQCXTbk1e9MKAD3L0TOkji AUT0Z0qiEC4uflsgANFHu/hYrnyn0FzYqmlOAagTCd6kpjSRBLV4UhNr3REKDChAHZ6QxEyjRJ58 vGfBCubtg+8EGPVOiYzzzbAT6nurXEFGKKuKkrEkEitgYDcBN3mKh6uEYp0kAAORQY9WzZQOY3Ug voiAqnr3ixX3bknFadKwkJugWSrAQwT8HbKSRVhkKkCgAx0gx5KnjLMmU/nKWA6ClbPM5S7fgAxg 3rKXx0zmMpv5zGhOs5rXzOY2u/nNcI5zHUIAADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/info.gif R0lGODlhTgAYALMAADMzAPLy742NcJmZM8zMv2ZmQKWlj1lZMKWlStnZz4CAYP///7m5pZmZgOXl 3////yH5BAUUAA8ALAAAAABOABgAAAT/cMlJq7046827/2AojmRpnmiqrtuwBAnGEFnAOB7MEXTp EoULQaBpMD6MQ0YhaTRMv6DDwWgEAgpFzGGkOA4GHKHRSyQMlUKh15smAISAsxqQcI8LM5phiFGi Cw0HfAVYWg5rBkR2YFQKBApHagJ1EgkKBkwLAE0Nb3GChAuIBIoLk5k6fwtAgU+brgsCeAeVpzS1 L0oFeBOPDpywscFOEpyzErW8rAB+q63FsMVrEtTVNMGw1hIBAGoAR8RP4sa319YMcBWA0ZzFBrQU 1AU4iOYTDIsGQQB1AuOdysFLdm8BgyDPgrSLFaBAg2UTqCVwWCDGtgUHcLzoJ6CAgANPXzyOecWp 4UNJNBRBnODCQ5waPT4Q0PjipRBbExLQZMmiJ4mWPoN6ACq0aAaiRpOuUsqUJYKnUKNKnUq1qtQB WLNq3brVKlWuYMOKHUu2rNmzaNOqXcu2rdu3cOPKzRoBADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/editorial.gif R0lGODlhSwAYALMAAEBAEPLy75mZgJmZM8zMv4CAYGZmQK6ulaWlS9nZz1lZMP///7+/r42NcOXl 3////yH5BAUUAA8ALAAAAABLABgAAAT/cMlJq7046827/2AojmRpnmiqnsMUEHBAxYlHWM5BJbBD wpWWhKAQCHwTI0G33DRkMwPFUBAAbiJjcEKQug4HYyARKBRqAbBsfEiQF4nDrTu9CXSLMDKHhzEW aWECW0MKMQsGDAxFXWVniIpSBAANBwYEAQIBl3QTlw4GPpVdPkdaAFWQi4MUQgtERg4MDRINAnRa s7UMRBKXgAeMXr4KCgUBAQoSugsMBVIAMsy2hK/DWgtKUlrY2r4EDgoHVZ3feQWddAqV0BLdrBOu 5QQFEuTbgwn1C2edl1r36pxboCyPHCmWFgAYsi9VKy4ADBigta6BsFdF+DVoUM8fjCITZ8shUiBR xjgBBpAVKaBsoYSKGR9mSIBkRw04NS3Q/ODg5oKeGHZacLWiKAiiRpNuQKq06VCnUC8wjep0AIKr WLNq3cq1q9evYLsOGEu2rNmzaNOqXcu2rdu3cOPKnUu3rt27ePMOiAAAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/about.gif R0lGODlhJQAYALMAADMzAPLy75OTepmZM8zMv2ZmQLKyn6WlS1lZMICAYNnZz////01NIKWlj+Xl 3////yH5BAUUAA8ALAAAAAAlABgAAAS8cMlJq7046827/2AodkPlOJJjjFZJJYlEFGHcUkHCBMtM CISJQYAKKCQKI4DAo7gkDUNhRWA0CIig4FpwzCQFgmLZnDwXiIC0x5AYEgGEG0hbhBeAy7NaQAC8 dT6BYXV3eTcSCSt2V20LDQ1obldyaEGHFS4BjgsGWQwJAgU8UqI8CAICDEEFQJkbAUETDkcSsWW3 rywfZ7sbvb4ZwMF6xBwDB8nKy8zNzs8D0dLT1NXW19jZ2tvc3d7f3BEAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/subscribe.gif R0lGODlhNAAYALMAAEBAEPLy76Wlj5mZM8zMv2ZmQKWlS7m5pXNzUNnZz////1lZMOXl34aGaE1N IP///yH5BAUUAA8ALAAAAAA0ABgAAAT0UMlJq7046827/2AojmRpWsMUCAJzHe4XJArspVIhHMJV ECDCQfG7TQCBSSI5I/IEScYumdgpEtVm4ZlUEFqoSWMRKxIKxJ8A7WAAD79hodCAp79oQYOw6E5w EgIANGZoWxJkdIh+h2dOiAxkCiwVgBJ2hURAREsIaAAUmUWcACwCm38qEqCHmEMKDhMLCaOaXoav sbWVEgELAgg9B79zacAHAcEFMw56AaI6CEMJzXu8EwQxVzQUCTEBqODaFt4UBH6pJ+rp6+qW7SXv 8CPy8yEDBvn6+/z9/v8A+w0YSLCgwYMIEypcyLChw4cQI0qcSJFiBAA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/advertise.gif R0lGODlhMgAYALMAADMzAPLy75+fhpmZM8zMv4CAYGZmQKWlS7Kyn9nZz////01NII2NcOXl30BA EP///yH5BAUUAA8ALAAAAAAyABgAAATvUMlJq7046827/2AojmQpDlUSWEgjEh9KLYhlwF0jKHpM IQzDREe41SS1gOBIaAoWMFgA0eIJcBSZpNBwuBo3gYNQqJEDNMEOUFBDFQBFudFIQAtYiRYs3zGO UGRyCQgFEg5wK0UScU8rfwqCWRNPBgsLCjcSmgsBQgIGamsSi3ASYp5tSxVanYcJaocwAmWRQhNx towTDKIYMoW8DA0LtG8BiFtthrloAg1xbQYqCwy9rBsEKxh1Fg152hMJLtgm5hNa5ybp6iTs7Sfw 6wf09fb3+Pn6+/YD/v8AAwocSLCgwYMIEypcyLChw4cHIwAAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/contact.gif R0lGODlhLQAYALMAAE1NIPLy75mZgJmZM8zMv4CAYKWlS9nZz6Wlj2ZmQP///42NcLKyn+Xl31lZ MP///yH5BAUUAA8ALAAAAAAtABgAAATYUMlJq7046827/2AojqQ3VIcgHKVJLQlBFA1HMBzCVqdE JJaGAKc4NBAIRaBQYDUYRAVDQGg4EDVKT1GIShoxxEKRiBUEy6ZCIBQoFguZFcubxCoLoiNw/63d EgwFCQEOFHd1EgtJhwQSMX1AKhIOi5CNFlsEAAEUCHpkjn6TfgyEnHaOiYEACwJ7fAJdoQp+BA5o ALKGDLhjsl4KWxMEOz6dGAdOxgoNBMhVqy0jw9Mh1dYf2Nkd29wbAwbi4+Tl5ufo6APr7O3u7/Dx 8vP09fb3+Pn6+/MRADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/sitemap.gif R0lGODlhKwAYALMAADk5B/Ly75mZgJmZM8zMv4CAYGZmQLm5pKWlStnZz1lZMP///42NcOXl301N IP///yH5BAUUAA8ALAAAAAArABgAAATccMlJq7046827/2AojmR2CMkSpBxRrZ9QEExAHAuqAfgk GJ9CT5VoKAQNlWAocSgmAQUwcAosGo1TcnIAuBYEgxEZPQkoBsNXCDwQwjnH4eCwTgg8MFC9OBQk AGhwDTNACwkMgTISDExXdXB8PwKUaAtqBQ1wDEKKZzmfKhIGCZEucBZABAp/cIENin8LBSyzDJx6 OUKzBYsThmK5BrcAAQIKt7ITCbV3Ww3NGjY+SNElHZXXIm/a3d7f4BgI4+Tl5ufo6egD7O3u7/Dx 8vP09fb3+PnyCPr98wgRAAA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/pnashead.gif R0lGODlhAwE9AMQAAGYAM////5ZQctm/zHkgTLyPpezf5bJ/mIxAZXAQP6lwjMWfsoMwWeLP2PXv 8qBgf8+vv////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAUU ABEALAAAAAADAT0AAAX/YCCOZGmeaKqubOu+cCzPdG3feK7vfO//wKBwSCwaj8ikcslsOp/QqHRK rVqv2Kx2y+16v+CweEwum8/otHrNbrvf8Lh8Tq/b7/h8GOIAOgYLB4IDDXo6BoKJiouLC4QrA4yJ BTWIkpcDMAYAlDwGBQwAoqOjAgUGhpUPoaStrq0MCoUmAwIJr5w0Bg8IuKQEApkvCgAMOw7ExQcD zAsKt6QCqTYOB9CkD7MjAwUCrQQQKBC9ruE1DgsErwjaMOoA7TUN6gnCJgXXANM3EK72Jga8Retz YoGrBPFmPGilgEY/UQ9wNLhFgCCKiaP23WA16l9BWBZLGPwWksY7AAhq/wgEkOCGAWgeTzToqLHG gVYx74FEsRAWjgKjOsnYRGqBDVYpW9wEYK6mjJE0WZAbdQDFgFcRbVwVlbMFUFJJZ0A16kJdVacy tkaF5ArVCVxCZzgYVfLFyVFuZXDMy8JgQ7Qx1HIt2youCVEcRzWdkXHG1cQA/saY2dhuWMAuBAPo aqLnqMuHAbxshbBGKGMKRecjMOOrqBgHUGPOjNPFUlIoXmsGUJFGL9Au5hpLplgGcQB1VRgAPjuF Zs4ldvMd8ToA1FGyY/xuDcAo5VIypjJtDuQ57domqgfwPCprjIXuYYQiCHm6VGzkf5hvsTun+gCQ 5QIbAGfBMJN7roliGP8LK4mSUH437MfCbg/+58Bdg8FwU4EvLNTUXL8MSAoDyUFIg4QrPITbW/qQ gBEppb2wYQwOJMAaCQ3CY6ArJJqYA4oq3IZYbi2SoCJ2JZ4wIwx+lXAkAPG1gCFv0PnIH3oMFkak kq4wh8KSL/RiXz4JJHnCk6MoYKaVKgCZQj6ibXkCexDZRqAmxZxwXHfv4ZLAAWuySQuWKlwHZQr/ keBAgGStAGYLxDRKAlGf6eXLn/YJahWhKSRWJqJFAgTnZiw8ysItJdZHY46uPJCppiS4qRMp0CVa wnejxJiCqSr0EyUJhnIooy9pBmqlrMC2IimLKxhajJm8puDNYiWAOMr/jTI0IN4rCVALqwjIiiBk tyzYasKeKAV5ZwubYMtTKw+6kA6xkX0bHUP2fXIXAq+WYK4J2x765bql1ttrK7/GMK8vCQu6mygI RIwAnAhUGVoLi7qy7AjRnqBOvCTc1RIOC78i2bfPRWJLKwicEsO/JrxIK5fCigOxxDjnDOfGNCww aoYoE9oAM8bK2QKaCdjXcQl00tuKNDo4wGq69oZLA8wnJIhYSUuPACIEzIQt9tjb9sudKyBDaDVj obbQNNQcE5wCUHD3pSUPzp7sMKc4YI1CgCd3LYI6PKNQ44g+7OmliWvL4PcJhysbd823ilK0CHSm LReZVfN9w+MyjTqL/+AL1X00Qz7Q2fnMPID+EWmodH34giyIjIIBFtu8IqyNw7BV7nryWI3cJoxk Ngp7emvdp0OFGDTrOvyukisCdH3aDJSKYroIM1HeAlirr/Uj0DJkTBrxk4riPQuqpsf8y1SFT/5P CtowmivrJwP8rEGdEMr6KiDF8cjTu2GhLzCv8N7hRoa9b8zJQQiEmL0CoBnlTQ8A23sK/lAwksW1 YFsxWUp2lCI+TQnpgKYZEg7o5L13AJAFWgOOWhqGgnfoTVN0yiANrBUnHCSGcq554QqyNz8e0rAE X+mRvSInQB2wR4c0OknNZHbE75GkBHepYgAwosRvOaBpxRjgCpBBvUzLpeBFwhoAnCxIQh61g04M 4IzPUGJGpxgAAs8gVvUGIEavDUABUyqFI2zwkLM0ABS4IMAyjOUACDwgkIJERQNYhYAF5OWQ9KDd DUIAADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/pnasbar.gif R0lGODlhgAIXAMQAAGYAM6pxjeTS24MwWcehs3AQP////5ZQctrCzvfy9b2Rp7SCm4o8YppXeHkg TNGywe7i6LB8lqBhgIxAZaNmhP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAUU ABUALAAAAACAAhcAAAX/ICCOZGmeaKqubOu+cCzPdG3feK7vfO//wKBwSCwaj8ikcslsOp/QqHRK rVqv2Kx2y+16v+CweEwum8/otHrNbrvf8Lh8Tq/b7/i8fs/v+/+ARAMThAU/DggJIguGOwUECQcl BwILLIMOI4QTjScDEjOUliYTMQ8QpT8HCBCZIgcLB50jn0cKCaMjiAgsDpuGgxOuJYy9CLwkDgES A0KPCaAkkjcFuYHXUgMQEAEPArM6BAYiAtM6CITNIpkFENYolBCNCwkIw7oiEgQz7e8AEhBiSDCQ qkcBAcoaQaJUcMSBfUUWBBhgztUDZCociAtgKEACCOpIFECg7p6JiyQG/yQgsAAZuBEFXr54cGBC SAADDMiEMQAjtp9PWoqAEI3HhHE+jk5ChsDfiQUGBIxAZ2IVjqYmEBi42YLgD6EkDICq1cSrLkUA wK5QOmJBwxMKnLb1SSAgAAUAHDxAIeDtiwJISygQC7TwGbACaBKYQCCmAgQKGhXoJunAg2ga8ebz Nm6CggEOFigIgGCa5bgcFdAU+ZjRIwNuRfR0h2iBhNLrCGhu6xHi4rwKIs9eMCDAKMurQwcgPS2z CKzJ6kIEUEDC5byiGzHWWsr5ZAX6BgxQ/WmBJfMFt49ltWCYgQQ3GStQdvxBM88HyIuovnrCdQCk FSUCaQRkEoABBETzmv9bLfk3SgGqzcLWIoSMph9jFEGAwFj/AXgKXQjmRts/D5RyIAGV2bfIhqxB Zog4sZEgAAFSURcAeASIp98/JAHAmGef7EWddQFgV6BhSH7FywEGPGQABPYJwJE31JFkG5P0SFBA Ao/tQ0CBUN1FkEq4JNAZbNuEtiFG7XB0zGQEuaJRXyNxY2ZeXCIwXVoTDFSkWwfgItacwtTzjzxH HcCknYoECpUk0I2gwAEejVCOBJMKWqQECA3EyUpfOpAALgIYAJkB9q10FwLawadSezQ2NBAuiwTw kEpLQgPSYKfyclBxARwVgAASBDoBWs95mUABwqoDJyf0LFBqMwLo+Y3/JoHxORAEg0k1mE0zipfA sKBUUgBKukBg6gCT0TmjAAEJ64AEuhYHTY3kFEnlgcKQIEEsBmQiKqmmDraXRwCN9+QDDJRKzgGY MnlgkUlWrAM9CJQoQpP/IHXUBLZNVc8Do5lKAEkB+4iUV0LlNMGBxY3DpIADvbLVhCs+Z8mBAJrs U2xQ/cuJA9qch4xQ7jzHC1Y8O+ALrZEOhUCpkmAKk9OVABDJxi+bepGaOHmFUgABXSvCA0IqEJBa ujxgQGQ/8yLAyJZ49VhaFAPwwMg5qkqLV4AVaZYIbLVM0FGJ9Uh4trExvXIpWEGS8WVIsZ3PqMwi w26YAHi1TcbEvS0N/1Iu43x2tbDl7LLevHz+QN3TKGX1fqBlbfHtNljOcmAEQTNVUQtMxxZbLCMj 9twQDQS8x4dnmxZTligV/FPTQKJxxlmDJVTqAJwMAFZKjaRA1lE/RM5ekJGANkudp0IQ22AVT93b u30PUZhsO6AQAsOSsL057Xue1vLGv5T4TWXuq1tDCmc8QtilBEcZhorA97jvWSJSnGObOkqHDIAM hmsBHIHy2sI7QjjPATWqS84CuL2GmEUpJFPfA9iHuxrKgG2AKcXHAMAkFH6DPz98GXx4mJMiEU8S d8uhNj4jghx90GalCFQBmESMZX0PL0eZzBABaJ79lApkikjfAuSRFv+pHIMc+6DgXQKClfSNYDUd e0YmJHAgCOElAUIiyEDuAyFf2Q0ZbruHCu+yl7s5BC8HoQlhbCItAFQrJqXgWCNPEZNuXOtlxdrK OlKXwxyS4CjNaGTnDpCTsQwDMJHxUY2yRkVP6ql7ZFQUy/DlSEPs8VhOgwbxiqQhSOboQK7IiSRy 4gvndTFspUjiHwEAJepwgmM8HAckmkFHnQTHhth0AUBoRY73ZKIu5MLJqEhCJndFpUjiYEXB3kMB AzSpVAhR13usk4DEkIBG4TSTNbYVAXdSIioHOadDRkUxUXFCANVKQJ+i0gB3fmYl0oKQN830UIQm oJ/Q5NXZUMUAdUH/QBbwSgTEolIqkMATYO+MCpM4Zp0SJFJaFHlSURzwtrk1Qxy0oeix6qGwBIjK ABMZVV/K2TVWdIJeC5ih3hA0DJqWiX7exGkqRShUFQ1GoRQt6VIf4AAI1FMS6aToGwUwmH3kBBUe 2dteRhWLcQ4AEgglwS3CWar5XA4hPRMARv9ZDn8uiiRu8+lP56OuchykHlvLpmJrgAmYFIRZneiX bNjFFRNowyZnFI9lJYsC0KSAsyjQH3UERjiTMMsvIomJSdYimUyURIeaWO1TUEsIFZy2E551KWod KxlOrMMvvpCtLipLC+LiRLgmgKwzcQsakxBiGLl17W/3UxBfmCC4RTywLmv3I93FevcKkDBR/b5b Am2Q97zoTa9RzKSnnZD3deqNr3zn6wLf0pc6982vfvfL3/76978ADrCAB0zgAhv4wC0IAQA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/current_head.gif R0lGODlhfgAiAMQAADMzAD07BEhDCFJLDF1TEGdbFHFiGHxqHIZyIJB6I5uCJ6WJK6+RL7qZM8Sh N8+pO9mxPwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAA fgAiAAAF/yAkjmRpnmiqrmzrvnAsz3Rt33iu73zv/8CgcEgsGo/IpHLJbDqf0Kh0SiU2DISDw/co KRjVHkPwRXR5ADCJgAjzBgrSIw5pgB0LR2L+2PcRWxAKeIB1AAkNa22CCIkQfQlbcyJ2IgwIdG6P AGeWACJsEGMDbQAEBRADBQcBiQQDBwUCggAGaqBtWAgDXQIGsaKfEKELAbsGmsElDMKhzGcACxAL sxC/wwfKEGklodyeJMy4qXEOnJri4c1t6dtgCAEEBAIEw+zC3yOhrAXSqb6J0nkbIC9fGACOwNnT 5g5CggEMIrq6J8LgQlEHAMR5sKAAAAcC2wRIEJFBpzAGUHo9CvbggQCKFcE0CHCmizN8t8adCQUt IieXbQosOhnmwTwCAaQNEEAPWbtvBugJkHZTBMFFuB4EKFCAF4MABgYg+9e0TrxXyUaArMlA0oq1 KR6YRMEgodxAj9qutJQwrd+/gAMLHky4sOHDiBMrXsy4sePHkCNLnjw5BAA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/archives_head.gif R0lGODlhawAiAMQAADMzAD07BEhDCFJLDF1TEGdbFHFiGHxqHIZyIJB6I5uCJ6WJK6+RL7qZM8Sh N8+pO9mxPwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAA awAiAAAF/yAkjmRpnmiqrmzrvnAsz3Rt33iu73zv/8CgcEgsGo/IpHLJbDqNjueSgXiwEIQSYiAd DgCKa5akOHSDDkCiIHooHgmrIhHFOhBhiKPhyD8YEHAIUSJUC2cvaw0AVhAABGwDBQdmCAEElmFY i3JckgcBDRAKAggFh4gsA2ECeQCHDAIkWyKYEFgQrRAFCQuyEAZmtqktaQdbbI6AuCPMtrgJBg8A d5cEAlkLjwnEKwmlCAaMyrdjIs4I5XoBCmwJAwzxohANCQEG3SkD3CLs5A0BrFhBpw7CAF0AGwk8 Zy4fiTSEgLEBAAgYtiwEmSkIMMIANgGHCAzwOM+hjAYVYyA4YNCIXkqTMGPKnEmzps2bOHPq3Mmz p8+fQIMKHfoiBAA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/online_head.gif R0lGODlhkQAiAMQAADMzAD07BEhDCFJLDF1TEGdbFHFiGHxqHIZyIJB6I5uCJ6WJK6+RL7qZM8Sh N8+pO9mxPwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAA kQAiAAAF/yAkjmRpnmiqrmzrvnAsz3Rt33iu73zv/8CgcEgsGo/IpHLJbDqf0Kh0Sq1ak46r8XEg FBgpBQHCCGRhDAPhAD4tAK816xFYaEsDA0NRRyHGDQUPMA4ACQwJBigMcC4HCnMFDXcjCgMjB5cO Cg4JkBB/EA9gDwkPCqYiDAifI6EkpyINYIwNCG2ziA8Ot7Jnq3YiCgiTZIMQw8Gbna1NBggjjKMC BAgBkKGMIgDVeRALAQjelYbHZI3V59V9CAIGBQNrAYPpCgIIBXZq4oMAYJniDpChZq3ZknSq/EmD kC5bIwB2Qg2AVMgchAMAuE3SxhAaR0ugxiz017HkCJInwfMAyNIAzkKETWAyYsCxociHYEIBiEcA 5YhTAwScE5GOozaH28Cke0MggYgDAfIl5QhBITpoTvCNeDO0JNKqOccEOETTYjSrRD02KhOyK0mE DRIEUEQGIyR/LU/OuvqkUDECimpC+0oyVAGsFhsckzsKwIMH984NOlCgLce30I6FOpaOZAAw4LrC bMKHALVBgr8F2Ju0bYMABAhcGiFXdh8IQakFFhBvtWWcJWUbEKA4Krx+YEpfE431yahiKRqcUcEA +k+asBhkscjA7IpZJKqfcNCdkvnz6NOrX8++vfv38OPLn0+/vv37+PPr38+/v3//IQAAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/advsrch_head.gif R0lGODlhYAAMAMQAAC4xIyMlGzo9LK22hHN5WFFVPqKqe5adcmhtT0ZJNbnCjX+FYYuRal1hRxcY EgwMCQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAA YAAMAAAF/6AijmRpnmiqrmzrvnAsz+1R0Gxx4KbOpwzALwVgDEfF3wGxExEQC4DBqGDsGAiDYnA4 NBYjxlck1ioMjSCVPFY8B+Ts9kDYoQkDwILQgI/8fygDDQZJBQhBAAcBIgJTBAYOAwwPiA5GBQkM YAiaAQaFWA9rkQxGAlCMDJCSlIcLAasKAEUNQiMIPmQJYCYDBAF9jApRsweFIgYIo0EiDX0OJAEL DAm5vbEjkWADlwwBdsumw59IVBAlgwJrBAAEJJEEBWm3zfJQxNNFzQrP/CIQntGjkmTEAQcEGDgQ aABWFFO30JkDeCIeCQAJRjxTIKCBggciENwKIEBEEma3nmZ1A7ROIwIRo9KBlDQRpck1BSX+adDS iTsS33jeKNCRlohDzgQU0MNvI7AGNw420BRp6qUwCTK5CSZA3VJqt6QWCEUR11isa0gcAHSmyYm0 FRkAkhuGbTK3k8IIYmBGULojgAMPCQEAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAQAICRAEAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/shared/misc/arrowTtrim.gif R0lGODlhBAAJAIABAGZmZv///yH5BAEAAAEALAAAAAAEAAkAAAIKjAMHidsLm2HHFAA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/dagger.gif R0lGODlhBQAMAKIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAFAAwAQAMX eDeqoCJE4dp5DddjzDCKQYFHYGmlkgAAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/Dagger.gif R0lGODlhBQANAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAFAA0AQAMa eDeq3KItVYwwxSkz+QFKIIoK2JiCEKSlkgAAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/sect.gif R0lGODlhBAANAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAEAA0AQAMb eCF3FS2QJiAoRtwChOHDYEhDMxAnIaCmaoQJADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/toc/rarrow.gif R0lGODlhCgAVALMAAIIuWHkfTGwKO4IvWH4pU/Ls8Pz9/X8pVPXu8WkFN3cdSmYAM////wAAAAAA AAAAACH5BAAAAAAALAAAAAAKABUAQAQ9kMlJ1borHSRt3pXGUYyHZUQBjCSztt0lVqecmmhhGMoM /wFQy+KbmIq4Dyd5EQySiRQPE9XtiMJJkEWJAAA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/toc/uarrow.gif R0lGODlhCwAJAKIAAOzf5baGnti+y2sJOmYAM////wAAAAAAACH5BAAAAAAALAAAAAALAAkAQAMW WLrczmIQEl4BLs5NrY1Vo23hyE1BAgA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/toc/dot.gif R0lGODlhCwAJAIAAAP///0JCSiH5BAAAAAAALAAAAAALAAkAQAIMhI+pGb2PWoC0yooKADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/toc/darrow.gif R0lGODlhCwAJAKIAAOzf5baGnti+y2sJOmYAM////wAAAAAAACH5BAAAAAAALAAAAAALAAkAQAMW WLrcBU4MQmtwWEl6c9tV2IFcNHRKAgA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/Phi.gif R0lGODlhCQAKAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAJAAoAQAMn eCcBECoaQOI7s5x2yhiAMGjZARQFYEhUlGpnEUxQyXmgqCmMIygJADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/content/vol103/issue20/images/small/zpq0190621720001.gif R0lGODdhyACPAOcAALGxsb+/wqqtqqurq6Ojo1xjUJ+fn9mjC8LAvtHQ0MG+vZqbmpqZmoWXbsvK ypWVlbqAXcnIyJOTk8XExLOyr4uLi/K4DIWFhaymqIODg/r7+/f3+I1nTvu6BI9xZ8KWGPDx8bWH k7e4uaempvv//6WkpLgAGaSko2tra52cnGVlZZUXK7e+vJeWlqeYfpOSktTV1Yuedq+nqsGCXKWx oPz8/Pr6+sTDxbWpiPn4+fb29lQ9QPPy81hPR+7u7u3s7ZZxT3KOSbd6VZ5zbp8cNHKdK+Li4pud mcO4veDg4N7e3tzc3NaQZtra2qsDIuns7NjY2KChofP6+dLS0tDQ0HGuD6m0o+z08qJGVK+mqevu 8aalqujq7vz7++To6pg6SrF4VcDAwK+urHKqE76+vr68vry8vM4AGWyjF7u6u4AeL7q6uri4uP3/ /7e2t3KWPm1va319fujn5+bl5bCwsPi6And3eH2aTKqqqrSHk6eop6amppWUkrW2uJ5XY6KiotbV 1aCgoJSPh9TT056ennWvEmyWJ87NzZiYmMoAG7y7uLmRHcbFxY6OjoyMjIiIiK+NKsQAGJOogoSL eo4VKP7+/6eBNoKCgoCAgLSzs7l6VaqQRnx8fLGvsHp6eqeamfT09a6trfP09HZ2dqqpqe/w8GiQ Ke7u73Jycnu4F+fo6MHDxne0E7OCfeTk5eLi42pnYLGifqWRZaufgpiXl5KRkbZ8WK0AG9bW15CP j5MjNvH4+JNYWtLS06+yqrRCU88AGMzMzceCWP///3J6ZP39/cbGx7W0s/f398O+xL90e/u6A1RX TfHx8cwAGJSnhcOAV/v//uvr676bNOrp6ufn59LS2WRZTOTj5NMAIvW4AO/v8rOHk8kAGL23t9vb 27JmcYJ8faF3arCwtJucnM/Pz4eGhfK2AKKSj6WkqcnJycfHx7irirMAGcLBwt/n5cnLzK6eobl8 Vuno6AAFAAAAmAABBwAAPgAAGAAAAABkTABATAAGAgAAMAAC6AAgACwAAAAAyACPAEAI/wCHCRxI cMMjUsMGPNJAsKHDhxAjSpxIsaLFixgzatzIsZYNjiBDihxJsqTFJHE4VmohMdOpYTrCeZhJs+ZM PgPbMEgwEJCRYcUkwDFXLEmjYaFQkIGiYkFDd7hMSp1KdZiSC8OMDIiiruGJdXbI5Wo0YKCNBxLd 8Bj2wxSat3Djvi3AsMalTiiUsLkxzNgoQsOaMDN2gRoqZshUPDBX6wGKZgLDLKm6MRgAylVx6UmS oRaicheLvZB4DDIXDkxSq16d2gMogdICXfqjGMUOaglRZFLyitMfXCpU/DGnAw5BMt8wZ0xwTPlU QIHcTGj0yF1oCaTXeoHUobv37903Mf/UwQxOhRcA4DhQUWMYlUcqjA270KQEHFSPHDBCOzCMEucX OeCGNGag4o40AIY0iB6ghFKLBHNcl+CEAKrjxjBnUQhSOQiVg8gL81xUA38aUojMKaCc0l5GGtAi kAHSeCMEGAgMg0iJlYVySS56kGGGQ3uM0kg562A3jAOYcIKjhj6QA9E8gUi0AQPDxJDKHVnIY0s6 03SAA0Rt/AKMH0sSxMhlyJQQBRUXZVgmgFLo0k4uvSTgwDyhTJGVARHlgAEsUMTACpZabtHllw+F OSYZoQywzhR4lOgOGdKg8gIDJ1wESgpvAriLnFkM04gOw/wBhRaLHNDcQ+9Qkgg3kgz/mqUthnoJ ppjg0DCGKT/AEApQRgJIxgTDQJHBJYNcxAOVnSr3aTvHxFAFMegIA8QqqSoC0TsrvBrrHTIU2iU7 twKT6643QACBNZucI0uCa0RghxnmMHTRKU5dxMBrGv5hhx0tINMQLnw8wNNDV8iJhLQNfGIttgfU yGq3eXwbLq3jlquMrqaku267LkjEwFojHdPVAI0QEqxAxuwwBQCYwJGcQJteNEQ3X5CgYQJOOJGG MXFQkQQPP2xghnUQJdwOEg1U0bC1AaQqsUPcJlLxoBfXSm6iYipjxa7JqMvuOSFD5IczOQ9UDZ8a AeAAR9IAZtHNX1wBSjMkVxTPLWpc/7EEG0o0okIjZkgzjw8Q8exEMm8U8kwY16SAwAEfsPmQFgo3 /TQQLKRK7MRWWyxuB1s7pKjXuwYgdruxROQHzhuUEIYrQAihQDkFaGsRHaBtVI3cFQ0RCRYsoGGI CEAAgUEsdWwiBUTxmEAEPEWgoYcLwnziyzmQeAFROT0z7jg60HjABuVRPeSFGiYgQUwVMTgsTh+p MrItxd/OyiXpGnMsAhgf0waiHvI6XhTPFMaoHRmY9y6LkOJgExmECkZBKprZjyNIq0zeMtKEn2xk HunTCA8OwZEavI0j6qgERwCBmwQB4AKPeMUFzCGBU0ShAieESA3IcQEGKMETF9jDMP9qgAd+QSQM F2jEHB5xCQbkYBiZsEEmcgEIiDBCPhgCQBgOkQRHvCAJEqjADyASigtEYQqjGAYAHDGHajjCHGSA CB00MIUSZAIZU6CDGnPgjg34YA0P6cQFHjAHTlxAD0O8TBKMwYMXPGCDHCEDCjwxB1SoQE8DkYC9 msXJTk7FMCCpxSYdkgkjbEAHOkCGKleJDFSispWsXKUrdQCKWb7SlqDIpS5BEQZMevKXFEnCBUJB iDWQIQVxrIho0rKWGijAG9CMpjSheUGBkEEJYAkFI5xSDAagggE1sEGkQoEKRigBFZEiSBhm1ixq ZIIW2FAhMCHShFwM4xAnsEOULFL/jFq0pBQbqQEyNkCQGjxxIC9pCMmMOAzJeLIcmZinRHCxB2zQ 4gEMyCFFlhkRtTTLP548xGUkChFAlKBYdkCFHgeCjB4UgBm1uME6/DkMbNDhEhIBAEOXRIYkeDIC EdUAS0hKkCnoARsqyMAjCCAiEhH1l4qYkQJs9NSBHAIhG9GAU6vKER8wSyM2YFYgfiAjGqEEMhBB xw7Q0Sx1dIIjWuVqSOLUjk8IZEqTJEUSgPcQZLBEUITCmK24NiaCwACRGprAj46JByFaBBlflatG 6BqPYTzgNXiAwTBUkU5WuQpWshrdABuiKHCowhNRmkJZNOSOGyRhAlPEotp+AIcL/5RjAIjFhhlW JlmMPCsTTQvCMBjQCy5k637eCq1gS0daXOnKEMngAAdwIQtIlM05aejKPCpwiSnIkyLNiCxFyFFB yT7LGwxz2LWOC7qrgWt0zCVIaTnmsbE10DlsUIcSHOAAdWDjIj/Il0WisCIKHeIWtyChQ8jAl6Rl zmnqjVrEkOverGWMsKgzRdg+RjbXoU1nRyrBHvQQIox0wgHMiMo3jtKQFVGDodIQMEXoBuKMAMCn GlHcFECQr8tOgHLBcPDSNKfezk24vaJbrsa+puHVnWMWHk6bQFzhpGG8AJISoYOCNVKNfQZvePBg RgGUMA8G2KAaGYACWh0SvelVz/8Xw7BnQv77vfA17hnkMx/lrAGRJ1CifU2LnzDEIYL6UTh/Wtpf fHPSNSaXwRYcbp3ZumFANCBQHEJYYB1k0QaLDMByEwFFI341kDnwdSI3I57x0iAOTXSCeeKBXiTc bD3sac8Ci+BCnRfXuCPkeQ2UawJEvPDnZLxP0OIw8jqQGwJEb+nCpusax9IAaXYJ0HXd8MMBEyiE ADDwIgNIVoLm0aNimAEPJFyCGwg6UQJMYQMAGMB/hoGL7z6kywDIAQAC8TmeKGEAAH2ID9yQCZ9i QwM6mEcwqggDjTbEAQxNwB98wIM/0ALHDlkHDzQACO8qQbNUWBEoQkiQbyBzA3r/+AObKsGmH0ym tzCP+YRU4AlMECIUwhRIEmhRAVogggGICDoDaNGCnwMdET73OdBpsXQGMIAcR0c6IhawgKZX/ekL oAXTj+70n5Oj6uRIwdUJkQKgk4MQYDdACshhgD9EIQVRIICaAiF3NRFADyUggNz3UIIS6GEPgAd8 3wcv4r/r4fCIx8MASKEHxQ9A8Y1y/ONJMYDKDyAUmL88HeiA+c1jPhSd2DwdAACAzQMgE8c4PepJ r/rTH+P1GNdILQ4q89rj6BV2AEkuPmL73lOIMyBxRBciAoAxdmoCVfT9m67CkX6mBTJPWEE2pk/9 6k//C9EQSCUY4I4KFCAUFWiO/w3ooII43A0VGrCkOThRg0f0TiDuELbyy7SECgyDDKPIxanjoAJG hMIAe/AHAqEBPjAaHYVlkjJvnBQMpCZZuOAkSlABF5BMysRbDXEMa9EWrLCBHNiBGxgE9gIAj1EL CfACKGAGA+Akh7AHSZBioIAK2JAXqDAK8zAKM+NQneQAKyVZgCCAEYAKFRAGoSFnEOFRw3AKXvAE T6AKqvAEXLCETegFIDAQNXAIo0QN8lQOsrUWSpAcPABq8KeAzXIIb9VbuBAFeOAAD/ACy8ZPRPgQ mQAZp3ANyVOHdliHsHBQcfAAdnABDuAIFXAbwyABcbAAxrEGyDQKmIAHo7Aj6v8khp1ChjAHHQmB B1CAIPy0VRe4FqDgAp74iaDoibJgVwPhBseAC1BACJ0mEMeACqigBKBwAfMwCKhQC9LACXYQcJHx cpzkAGUoWTBQAs0wD8S4U8PwCJ6wBCiAAu9nWS3xGjXABmJQep3AetbYCW0oENUACFAQCGSwAW6g QoMQB7mAOO5QCq8QBwNwFg8wfANhBpD4JhFwGTXgIlw1BUKUBG6QAavVEK/xDVBAEM4XEQMwBUZg BEmQkAppBK9wkK+ADdjgkAiZBK/QkAz5kBBZkRq5kRxZkdhwAvFYJrCFIRYoUeUwAgnhDlCgiREx IvNHIQhwDdcQAc7IVbdlBuz/hhH1+JJVcQiOoAKPQA6jgAcVIA9gMFVDVVW3BUUDQAbiJRE7yZMQ cQpPaRFxNQyEECMzUiNJ6RBQ4AhC8jllIlKBQAXHUAFbFQFwQAY5kAHmQHtRKZUO4VUPkQaNkAES gIkOsQFo0QRw4AYy8mzLIGnRBgxY0CwOwAYA4A4+4ANTIJZqpAKE4AOj4Al5UwNdKZcCEQ3msANb RhBz4GV9hR2AhQGJdijlQiYCwQgVoFIISBnGwAbDwAYPgApsUxEacCOaSRB0RYoC8UDD8Aqi6RDI 4CKANSu1MlryJSaqKRBTgFUU4g4/wgaPAADiVhE5wJJSSVnDQA4foQd68gon/7UtlHAGoBVYyZma avQfg9CPEzIp84AN5uAJ8lcRoGCPuykQz4IBlvUaJQAF25AqYkCeyYWeqElY52IKXAAIADAPZrCW EeIcZGAda+CKw5kDuPARRqCXw7As+TkQzxIqDFAMwxAIS2BcB6A7VPNZSZaeCMoxpwAFzVEJ2kkV ayAfSVALmOCexcAMKhAKboAKKBBCOZCZmvlb0kItD8NeVNMt52lh/MM1Z3AuhlBf7XJfyrEGb0MK EZAEFcB74FWjLfYDRGOMRHVeSVot63UAPwI6Twpf5ZKgVuouCZJfw7AETNSmFVEKnKIvZnqmcoJe ELakBzBVSIY1cCqlcupkWP8KmhWAApcgmyLBBg5ACo9wqUJoEadwahOBCOVFIfAgWw0RBpDZEErD NIMKBBI2NQ1RNRWWqIWZYRs2NtfFZjsgCCRxDMGQCY0gAY1QTRTxA336ZVI2ITr2EBMaEadKZFCT KhnUqviDqEqGYUw2qyATZTX2A+NpY8HgA2mgA4hQYgRRC8GQCwlACCNVDWagm8GDMzX2WKHAdxeS EeDjBFNQCvnCAJAxDmmgrA+2OUbGqgThqi0Kbc0FDLLqZFA2acU6B39QA9KQZn9KSgr2A/YWrMM6 Y+66ETfGA05pfBVRr8EwCcwgmz5GOc1IEMuaqkb2rAMbre81rbHKZAFQbaz/g228MBDbAASa4A3D UAuvGUifiRFywKkRITxfAEU8gQw2kJMREQ+zBg+mYAoC8LMCgQex1xD1Kj54Vj7n8wF89hB+Bmjw U2TOemjSqjVLtiuPFmk4+w0FQAxLoECxsAycZhGhAIYYMQ8CODfdoGqG0AugIIAuAAlAQKIPAbW0 dj3ZgwEHAAm69hCKcwO9lmdugD7Dxj6oimyFdgDAShBeQAShk7YGu5wIO202ew7KSRAFtG10u2mr SBF4AEEZEZo287fFYwis5mqzUAeWMEoE0WbUgwY0YGu+gGuR6xCTe2d59rUBqT6aG2jy07nZ2BBe ALP6U7qMdrq7Qm0BtLoD//E62mZp3KZpjSoRenCdEoEJc1ACZTgAKMAMlxAH9BsHmFC/+Gu/PaAG O6ACPdADzNAD16AC18ABPcAJmJDACowJl6AC/IsCBWAKzCCTA3wNPYAKCUy/GRwHKMC//ssMAWzB BNwDKMAJnnDCKOwJcLADauC/ACzAPeC/A2zC/+IJdlCZK6wG1wDC//u/E8wB1/AvQizEo8DC11AA Pvy/MhzEozAKdmDD/8IJLNy/PrwDMSyTPVDDKMwJXNzFXBwHzPC8HzrGmlmCAvEDODUIEogC8woR pDCvh3AjeEAOtHAJa+aVjiAQzZABwwAIjQAKFTAPj+AGKAARmYACJdBlGf+ADXiwDnBgB3+gklEA EY8wD5XwCDdgBypAC6SACcPgBp3VEI6ACYGACHGwA7LZDBeAVlNgpGQwnvV0f3rgAxVQA2EwABFA C3QAsmTcy778y8DsEBKQC0FoB43gWMGczBoBBz5QC74RDI8gEGcWB2Q2D9VAjNZ8zdhszdxMjNdc DddMDdsMzt9cDXNwzuhsztgwB+sMkRlZkRdpkRapkPScBEpwz/Z8z/q8BPy8BN/wDUrgz03AzwD5 DU0ABQiNCwoNCIAAA1MwCIMwBVOQAOVABRWdAAlg0RZdDuVwCB4dDCDdX+rAX/w10uqwDusQAevA CBOwDsZwA+7gDhMA0zH/HQZkcNNkEAZmkNNkkAZrwAY/7QZuwAZuQAiFLBE+wBA5cMdxRnvK/MvY gAogIQFg+tS+nARK0hFVbdVknHNaHRGHYACk8Adu9wdyp3d8R3eksAdRMHhREAh999ZkXXeDpwdr PWJ853d4p9fk0EJcHRLAxxG5ALwEcQy8vCQOkHx/DRJevREvgLhwiDhTUWAV4Q6KvdgbwXwbUQxG ShBuABnE1g2RMNqkXdqRoAbZNwwTsAPukABxQAYqgFPV0AOHQAfzAMbFIJl2EAfqgAqvQBAqidkg oQTRPA9hkAZZKxHF8IYOgYHD8ATs0w7SPd3U3Q6oPRC5QAZrwH+P0K8J/8AJ2FAADrABKDAPKgAF j+wOKFANwF2fnUIHFVAB5BC0wPQNucDeEQAIyMBQ6yEBPICLujgMnT0QbEDfCeIOvNgsCTBSkrWS w+AOT4ySBJEJmWAHnOAAh8Big3ABuRcRx/AaxcAGvjDiJF7iI56p7lEBYiwQRpA+a/AIxJIDNFkO LfADotAC7wdSnRQMOyhXuHACSPUIEsDgAgEImGAG3UTVA1EMYupRbZEKUB7lUg7lIPiOj9AInIAC iIAJwjEMG3ABKKAHG0CLGhC/L6AkGYBJZJDgneKLMIcLJ6UQjdC3ysTcDRGHw5ADz7DnfN7ney4J NDCABVAAjmAqf4B/zP/QHD+ACnBgfjzwpebwo+4AlP0RkksiUpOYKWQwBdLg1BMxkEVo4MLC5m+C 6Wb4B6dAC31H5xtl5xMOGSBQwNI167QuXbBgL7mAAo5QCYjjA5Q0DHSAwSnQDMKB3ijgAJygAogV hp5EBUTOVbjwB8eQC7XgCA2mTAYIEc59GqzR7UzgAbtAMw5gB5fgDhQEg8NQDupwAWk0AYRABhfw AuZgT0dtTe7dKeXw7FV1hvIbCAOgWW7ITAKxBApd8Aav0DCAcdJQfNIwUGywZWGgU8NQCiEyKcOQ BJ3g1O5g6Thi6jwogFSQAY1w7RvV5KKuETpwsRerTqReJsHwi3IFCJn/smIPUL2fnu0P4dzb0QEW 0PM+//O+ay9KsAMtgAJcDgfpJBzxxwY7kAQL0JoPQNbI/OAcXyIOcAzzkAY+Iq4kNQiOVQOUTRBj 5NACKaY6bwkfkPZqv/ZpzwE6UwrwoQIvECSloAI2UANwkOHRbAe4wAlkwAmPUAvVSRDw6EkOEFHD JVdTMAKhYA6O8AgUKBATwAy5QADuEAEGOAdsgBURkQkTOyHX5EnrEFGYqfgoSQqNwerD8A3kBAjL +JliekfNEvqdtA7NcZVVlQB6QA2PEAgpMJzKTVMQoQRusAZr4NPIb/xpYAZpoPVmYPzGzwZswPw/ vfzJ/9PST9RDLf3b/6/96+ZJE3AZLSJX5YBICYBRMP/pYircDiECiKQBOE9UVFAWcyABjkCTFlED Jcn+Oa8JtjMMAEFr2ECCBQ0eRJhQ4UKDwfQMm9cMGUODNVpQxJhR40aOG0FV+5FkgjEHtTSBUTDs QUeWLQmWC6WiAKZGYTRadJlT506NKQaWaKZACBgEwxjwRKrw0IBhZP7Q+aOxy8WkVXmGyYDCUZKO NiQMNCDN29CiAhXaGKahklWOh0KlBaCHx02qbO2yPEWupQZEA1OIHepuGCGGUaLd1ejg7bA5hBxI XYlYckYfZjvmoLpH1FhbpCwtmpWwzS9nXyZTjJAJGR5aC6gZ7AQA1f+eFC0AEKxx9PTuhKd0G9Qx qJEPhTkENkATJIs8W+mmLYsl+hcwLLwVqnPDoJbggwOkjXo0wMDDYcV8vLCenqCoKAkbL0R2MQar OxiYO++AQzowPwRxkVRnIt6MOaYUNx4xR4/XCiomIQ1+U283KXS55TcfTvmhmVcMgO+r+e5Yrrlp 8tuvP4K+Wcw6RtgYpgsfDjlFI68itG7Cdj4paIAphnmFMIWQEejDELcYUT+ERuOvoEFIUc8dM4YJ A5US9pARQholszGegvBIYBgjfBSNQyGZI5LEI385w8SBEmAyPXfIGAaAFMhQQqMc0LvyNBvNWQMF AprAY8dXTlDoHTX/2mlFEvpCxM/Ig5D0oxdzSoAChhR5c3IYUMipBRuNNugrz8myHIaPuUgZxEtC E3qHkkS4URREMossMc46E2DKTcEyOcYBKxfSwTJR7yL1AVCGGQGXYgS5BgpWXYV10ftoPRMYcGhA w5QfAOkEm1AyAaDOycJwxx0H/ogCzoxAEXZYtnbRpZ0shsnlWEq1WOQACp59NdYhqX10umvHMIUL QBYL9TQyJrBhghRSOEQjHsB09914561loj++wfcAFhFqtV9pbSnTUYOQHFjbQegYpoavdjPDmGHM COQRvQrCZJQLHEABhWoIyuHXipGCtx0KfOmBj2H+UKJjRfjNw99Z/80M2FoaCE6CFkxy0AKTDXZL I4I0JMgll3UM+gEVXHIBJJP2hhmEAUeGtqvoTGIohJh4OIAlmHyfBnkFke+QYWp29kv5BghmsGaT OmSB+TEdkoigkYIquSETm8KImCAe6qI7KbtjqIIYdIQBYpW/WRU8WsINR/xqQxSHoPFzID+NDXWG SaKCCrrMiIeEQyc63mNINx111Q8A/KB3Wo+1cJJHPLzaxCGofRNtcJ/MjMccGOUSFC5dqJTIKJqD FhUeWYN4hYr2BvlPlF898ESipk/6MqsP+Izrs7/dbtywuxEEoxq50EgzbpYRWszFfQmBH+kaML/U 5SslIHMV/mQ1vf8O8O9kAruaKWhnO+4dRAPl4QkbHFCNR+jhZxopxQI2woBjpScHNtDA1wxiBjzg IRMnPEgEqzBB+h3ggs4TnAb1R73YEWyEmwhgQirxgB/w5BgRYIY7OOGOeWjkFBSjSAtqaJ1KOKlB BxmJQq4QLyQ0YIgUDEC+imI/JcKuWsqwghOxZzsXLIQcOtRJJh7Dkh/4RCOEEJB1knCNa3DlIGGY gBrZ6EYiAiGOB5gjEu8XPTtWDY8ES8YeodjHhPAiEl8gwU4ECYAKOOIRNqGMITHijR2gQz3lcIIT yoEQMnAHIWtsRxvfiLpLZtIgz9tk/jr5QWB80hShBCApEeKHbqD/ciBzYAMmyjHGjADgMdS4BMQO 8o1SDIMOZyPIDxZIkSFUM5XWSUAuCaGHQATihU3x5UGAKcxKFpN1yXwdBz1YECQ5E5p8VIgfSvNO xoCxm8FgDBxQgE6CzOES5ahAEgawmEPUwnIZaac1rYNLJwACFIHwASJUYI4ILEySwaQkHOX4zzoK dD8GFeU5QpMQaop0GHIoQTUe8Ihc5HMhmTgEM3bnAAQaJAUJGIQK4ECcgZTCoQoJaRs4UgMqXAAP gOhIPJ0wiFLohhagSAAHGpmQfcYUdSyYKR05adM75vGZOd3pNN1Z0UAMxFgaAcAhqJEzTixBI9IQ WkJCytCNhKIJ/2x4xAVoQVWKkHQQPLiZGCdwgA9A9JeTHCYQ4HqASMpVmXT1pF0PCsW8HqSn79yA B67xmFo4ECN06FxHfsAhkJ5SqxyRRjgwMIyD2QAkc0hkQkiajDdUYRJG0cBmP0AFtoK2kqMtrSZr ur+b2jUAtgBgdHhaTT1koJUckMfTEAFIitBhlyyZx1UVW80ooGIUq8JIPCJBBC/o4QLlpCE5UIAJ 8hFErDd4QyGegQ5NcGANnO1FQrRACZhWIQYUxC5N58rduhLsu+FNaDd4MYw04AIUQBBCGGRxACBo JBTv7Ug13oaRIZxyGFtQBxkwAQdOPOIFEpAZQvRLBHgUAQ2+GP8GnvYgLoQsN8ELhoYH2MBZayTk CZQwAT/nJw4R5IsRGj4tfgZKkILatQzgtZ149coLFmTLGOIQAhli8bjfUiQU1GVJNfoK0m5goc2G oII6h6GDOLxCIfEwAZGN7It4XIMCgLjGJIB4ELEyV8HoiPKUP4ALK6shy268sDC47GUwb1DMNw1h GtAMRTW7VsRtNsUqUCxnOmdkAMDryDxmzM5I+BkNhnCADGCRBBcsYxNSSMiQi4wGPbhAGJ/whQUW wQXl5tLSUJYylRPiBSwjgRgW3nIfSG1aUzPxjiEUwaq1YTKDUNMPsDbGrOdcQoZwqSXV4C2Ne/1n EYhDE52YRR3/jp3sRC+72c/2xTmmXW0nXBvT2d70trsN6nCPW7tSE1EHUU0wVWdv3SF+t5vl/TiN kGJHLJnDnmnc5z+bwd+dmLMlJm0QRCsaDQJwNrQtAAlqI6TSCT7CwzXtLIRwO8vfDrU4RkvRYxIB oIwytyfRDQaPs7sg7ob3yOm9kD2kiiIMoMUowDqQeUSFz742BBleHotlyDzZ+102zhGu8J5T+ha3 QHAVgh5lRXC2CRI/OrhF3eUDfDlwzlCiJuThnGWMeSAFpUEhDHHmqifUGSE3Rbw1EYB5uxgGGDFH OXKhLh4cohHUmEfq54F61bd+Hj64Qil+sI1tYEIVWvjBKbSw/w1pUEMav6eG76kB+yvMnge16MU2 TqH7bfzg989//g+ucAUfbIMHpHADCEpR/eZDH/o/EAX1QcADMgRC+9XHvfejP/1SlGIbCXDE+beh hVOo//kgiP0ptvGKDLR/9vS3v9/DPxDgPkxwhW1AP94LQO/7AUTwOorggRp4oAmkwAq0wAvEQI0A BU/wFTKAA2O4hDS4gBTAg4WAgjjoKDYYhQkYhXmgAmZILoNABk8ohxJYA1Q4hEeYAEZgBmm4BEZo qoMAgAyYgHn4AWaghglAhAeoAHd4AVrwrIO4BGyogSWoBEa4BDw4hCbEhRFICBXAhB+oAHMwg0uY BzZghmOpAdJMuISDmANPGARyUMFD8AQoiAIV0AEU0AtGMLyhwQZOyAFGyIQ40AFSeIQHaIJHWIgw eAANAIABqBdX8oQdGCSE+AE74IEbGIA4OIUoYIpHaAYziII2RAg6IAdqSABUYAZyCIUTIANSuATd yZWDwAQYAQAVcIcKUIJGuABAOAQVYC+CyABsUAFOwIQIQAUjGIZLKIWJSIJaOAgouARQyIQBeAQf cIR1qIQLGIZD0AMAYIMlkAbiOSODWAuKkMCKKUeMCIQHzMB3hMd4lMd5pEeGCAgAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/content/vol103/issue20/images/small/zpq0190621720002.gif R0lGODdhyADAAOcAAF9QhY5dha2trTExMKytrMMDJXd2eEpOWWNiYdCwtaenpysrKqWlpTtFKY2g gERSPzhDJklIRNXU1JmZmZeXl8vKysjIx8bGxcXExPn3942NjTRBJYuLi8DAv728vMQAIru6uk1O Tra2tVRSbLW0tPr7+7S0s7OysjVDVPP19Kysq05dSKqqqT1HNDxFM5VTbTZBLTtCKFNTUFpcZNW9 v1ZWYMgDJYqIiXJugv7+/oKCgTs7OPz8/Pj4+Pf4989ogfb29kVKO8YDJkJDQkFDQcDCt8IBIj8/ Pz09PV5dZDs7Oz9FKzk5OTc3N6KhoDY3Np6CjzU1Nebm5o00TWRoYy8vL8gAIaqrq0VHNC0tLc3M ymBgXykpKdjY2EtKR9bW1lpaWSEhIUREQDM9ItR8jz1KOc7OzoWHgxkZGf79/cbGxhEREcLCwkZG Rff39sDAwNLTy/Tz876+vvPz8ry8vLq6ugcHB7i4uOzr625tbHFRg7KysjY2NbCwsDQ0M2lpZ66u rsQCJi0sLN3d3GxbVn+0fCgoJ6KioqCgoDhCJnx5gJ6enjZAJJycnNDPz7nQq0dQjlJRUJaWlpSU lMnJyFJORsjHx5KSkpvX1sbFxUZGTsTDw2xPRcUBIz5HPLq5uYSEhLi3t5LNuTxDJrGxsK+vroFS asUDJmqgVnR0dKmpqMvMxm9yb6WlpKSjozdELkJMPLFTbjdEMb4UL93T1GpqbTM/I/////7//kxM TDxDL7e7q39/fvr5+vn5+URERPX19UBAQPHx8VpHUz4+Pr4AHjw8PDg4OOnp6dJYZjY2NjIyMuPj 4zEyMeHh4S4uLllSS9/f3ywsLLu9tdvb2z1FYY5nk0dITSYmJo+SjWhkdDZCJdPT01RZU9HR0c3N zXB+a7RngMnJyf38/Pz6+8TFxMPDw8HBwZW6hTNAJb+/v8YDJb6/vgwMDL29vbu7u2tcke/u7rm5 ube3t7W1tQAAmAABBwAAPgAAGAAAAABkTABATAAGAgAAMAAC6AAgACwAAAAAyADAAEAI/wBvCRxI sKDBgwgTKlzIsKHDhxAjSpy4ME8jgTyIfWuYhhrFjyAZpojG0FkIL162xAvJsqXEeAxuxWOhYY8T apfmDYxVrMApI0YKFAgktGhRokaFChkaSIhTp0Sdnjq6tOipq0LWPd2qVIgNIaeaerVRLIHAOCQV ejNTQZ48auUcmflSwZKJcibOdanQ5csgCW/YYCg3uNy5cuXYbEp87s0mS5nYaLlFipUaZLd8TQIT qVu3SDK2UKDXB1SkEDLA5GoTTEkTP8sGVHmWZYHt21y4GNrNBSSUcMCDCx9OvLjx48iRxzJ7EEja hJbknDvHppy5TeYsfXvzpsI3OnfcDf9y980ZInOZvGUiVWETGzlyzL2ZrviNnO63Fi3w4yeKfz7H KDEEAqzkkQovkwwyyGZggJHKG8JYUs4tjsigxDF+DCBbFtIsYIiHu/lGxogklmjiiSimqOKKLNKA EDDPIWSJPO/QQcc77ohQRx3zaFGKOt/0UY48ltBzgRxqnOPBN9+8J4Uq33jDhjelfJMJHefYSEl+ XCzDHx/KHMOEEkcM0UYuoRmgwSUTUKCACZHRcQUofyAAxhZvqOGNI4pEYoxsHS7Qm0IgIAIMKEBM oAZBPK0T1ilCBIJUWIFcNSlWX4FFFKWRSnpVAY4GYsNXo35VVkvAOLPQJnJsMg89ItD/80YdHghw hwTz9PHGO61kcoUIIqgyzxfnmMAMPSy8kYk7e3zjwTx0vOpNB+rcgkgVSgQTAi9OsCHBNxhU4M0J YMjQzRYEMlCHAk5c4coijUzyxyJffMGMMxwgEcUACwTDyzFcPPNRGoO4ZDBIqS5kySaNqKLCIRV4 4EQfJvRxRx2qmCOOPCzcIQ8pJ+xxAj0mzEMCPfPcEasJLHPjCAifmFCtCkj8AgYHi2gAyoE6gEEM MUTIkEof3nyhBSttHBEMEkwwoYwfzWwoTYdchMELKGhgE+LBXHfNUjx4MBMPMlIgYzbZZ5NdthRl p+022mnjcTYet0jhSDxg41GBHDfu/1iHPDu6dcfgd8zjluApFz5PrCTvwXIppZAiwh0fqSAFMJdI okI0TvDyhioMAKKAKm8gAoorNzhySxehyGHBBIio0MglDIASDQ8CUDBJPNHoMIEqoy8yiTsaNHLD DU5o4MQlLNyySQWqNPIOMLeooIAkiNxyAwMMICLJHRosYkbzCPUgwxNKOB3bMlEgMYQXJ7UxRDDw e3baEFHApqGGVchWxf9VyML/pNGGNAggBHcqVy5+YaYt5OEGKjDBJHiRCnWAYCO3MAMbzrCaIRwB CcYY0zGaQEIxMeEYI2yC11bIQof4wAvS0FAzvOQHZSjhF6hJoIOc4ARXuEIDBvhDuf9C4EFjHONp +ttfFQh4C1cMgAlNaJoSlIAEYvyiG6ngQCsWcQYdUDAVYDRAHv5ARgRsIRJeaEMbfsHAYBzBGFM8 oQqN4QUwrJEZLcxjC32Qixg2oz9RCBMSgoGASUygEYCggyPE5gxnSEECyGBGF/rwQ86ghDVNiI1s FtCGHLiiCmJSAhyniAQkKC0X3QADAlIhxlqwghcGMECB8lALWhrAHBJQQwUccQ5WhOAXbjQGEgbh DAnshRr14sY3OmCBT6iiFSdwxDh4QA5qjmMc0bgDKMIQBgS4QgEsUIHuNHCDRRhgEaAg0CUWcYjf XQJdy9iWI7rgiGgAIwf4TEMarpn/Bh74kwf6vEU0qJADHpSgFz0oATniMMlLlPME3pDCIoaABGyE QQm8oIcUenEQH4TAD2NSAjGCQYTWNI0JxiBGmX7RhvqlEgyf+YUx1OhBJcRmNs/IKSdzoAAlgMEA tdAALwqEABmkcQgqVWkwWhqCLRhAAbt0hQHAwApVTOASl2CFF4hADDg2LYpdMIM4qKGGhamjAu44 gTrM8QVj7tMZ77HAN8ShDmowAxgGzUEahHEvbqijC10QR5LYsAfdTYAU3ChbNJwhDDzgzQy6zMQm EKGO6LxLAVdQRR8YoIJ5EMMOqVCFPBwxh35Osxfj6AUy8ACMfe6VG9yQwBeoMQjq/xnEF93wgxtV +sEM/U9D/VGGMjQJQADSJqdZQK40nvENGYRhGUwYwjjcUScNAEKzsnLFH7ZaymCwVH5wRKEJ5UhC 4ZpXGc/QQB38YABmKKGYZnCEN8RhCXfIQx3zlC2THCGOb1iiAmp4wx30xLFSiAMIBwVG2aghW290 QQISEIc3NjEIavShD4BAxB3oALpFLKJ7oOCFOyUxCVdQwgQsoEMfVFAKFdCBHpcABStO9+FShPMN J/iEMOYAjHH0sxd4aCQz0nCQHnSjBRGoBCde8IJYvIAQw4gyIZKgB3hY2cqQAAAksjyCAxxgBFoG wJXhYQ1rBODKAXgBJ4KABRdgQf8XcG6AnBsQAzkvYQlYUDIn9tzkZPj5z1PgBBawcOdKrODQhMaC FEyggQpQQj2Ac0cXzuGIL3xjHnfRkziWdQ4BqIseWGKDf52hty5IgRy+IJs3rsBqBdxhD31YhAre YAZn1OEO5rjCIVqBaUQIYAIMmIdcrMSGC5zDHe+ghwBE8A4BXLgDpFDBJa7ABgYIgBRvGEQObtED CSzmGz04SC/CkYwfhMMa57YGmk0BhhDk4hrXyEUuQhACaECDEKYwhR72zW89EIITUwj0ngdO8EBX YtAtcMESdDFnCMy5ARAYxSgaIHGKS/ziF494xDE+AXU44wuOAIUODEAHEJhBAmb/GITdzGGB/nKD GhWwwB1UIQcPmEBPL+uAfC8AhF6kIR6kaBMi5rEHQMzjEn5owlI5QA8d/KEJxshCGBZggFLUgRSu aEQenNCYd4jgBI3QARCFiMBGuGISk1AFIDxAgneUA0smAGcFJOCRg/jCZyjIu96JwHcieOLvnoCF GCIQAjADQA8BCECZ1U1mMwfAFOZePBRM9INYEAIalaiEF4LAeSy04PMLX/jDIQCBbWxjA9ugs+kZ kYjSr54RjLBFHxzRyC+ooRZN2IMxqfENR8ijA9+owI7YkIdgeAwE4ghMH1pxCbXvYR631gAHfMgL XtwgFYbAxgAQkBNuMMMCtfBC/yCJYQglKMAcexCACb5RB3eo4wt7cMUVGFAKMGDjCE0YAgeYEV8J iOAQYFBDvyAJIrAIl1AKVyAO5IAMQFBkKwADryALEhiBEugCFegCn9cCZQALXnAN1TACSfAHL5AM 4fADJphu6mYNtWBGhEAFW4AuirB4ZQYFUMB48AAAkVAJsAALnjdoovcKDzcKpLdxF5cIjLABtrAB dSAJLHB2dLBKBmB9tdANilABmaAGFgACLEAKcnUBk3MC5xBg58AMgxANgNAIjeAmy3YOkgAKEzAB KvAHYWAMftAlW0AFrDAJieEIElABd3ADrHAEaCADeyAsk6AATgcKhiANyiANYP8QDLUACIvgCo7w Bl3gCqlgDFQABsowAAaQCYegCnXwDURmED2wAukAga+wiqy4igmXgRsICw8QAkkgZlZmDTW4eIpw Bg5QCOiADo8QjMIIjLvwi+hQCMiIjKiwjKgADoeWefY2cAc3aIR2Z0uAcRK3DRDACNvAChTABjeQ B0MABhpgAWaQCX3xBdzRAWxAD1fwBsxiMVIiB33ADk6wCKRwDqUwD/PQAX8jD33waD22aBygAZPQ CBqgAabjBYaQIVwwBErQIWFwBBqgCqSwBwpgkGegJh42AaVwDoYETefwBe/gClj1DdEQDY5QDmow NhNgANzggDAAZxFIgRKYgZ//VwY6uYEP0JOHtgLMiAq++IvCWJSrsAqYkJRKmZSicIyFIJTMCA4/ QCIlaG4/8Gd+Jmg+GAMZFwOtR1Xt1gYIEHOWwAaqMGMGGQ1hZQnW4wGbAAhbeA7mIACqwAJ9UCOU YAEksAeQIwKfcCUV4AM9MJiDmQHcMAi+0Avx0AV4IAzcoAAnYAI5YwCKkAp/MEa1wAuAIDZdIAzA kAHCQA2d6QukCWRmoAqLwAZ40AOk2Zq+UD4PqAsuoAuykIF/hwLVUA0ocA0PIIu92ZM+GZRBWQii UJxLeZyYYJxLWZzKGJTg0GexEAvSiAVO4AZOUAmMcGcxwJUXtwTm4lSXIAfl/7AHdWAOJmCSknB9 l8ANXVAHFVAB88AGd4AyJgAITmACIqBrIqAOLGACg4Me3yAH7vAG8eALhEmYvsADviAM7oAAy9AO TGBHaDB1XtAN5IcGa7AGdvALqWAnSoANa9AO7bAGCwAGdbIHXTABvPAF49CahIkQPtANuvB5gNcG mpCbW7ZlWpajPIplQCmcUQkODiAKyVmcRmqkE6ABZ6AIVlYLhBB5MlhmiSedbFaNS0BnoxADY8AL HDAGDqcLfcAGrJAKi0ABwPOG5WABzrAICjAPuTA0CuAB7iAfdOANJkACPqQArkAP8AkI9FAs9EAK fSABCPUNd/ANeJACt6AKv//kgmCQLZHQBhiKBsSARneyBQ1iLl6AAOIoAzJwBLkQqWEQomtABbzw B5gqCeTQC62JT69ZZGDgCWJwANWQZYcXAMCBeAGgBwDQq9VwDW2wg4G3g7AQi775ALnQk/RGbzWg B2UWDiUSDruaowfgBdAojWwGDVIwDd0wBoywnV6ZCOK6DUcIe9+qBvNQHixwCXYlW5NmCeaQDbnw V94gB1qoAG5iAqXwBn2gCibgDoigCpLAC2dgAhxgIAiAAAbQktygATIwBKDBBQPQBNhQBe2ABmCQ B5xhDHZgB2vwDN2QB92ABiK6BgMAU0qAoX6AABxQJ1sgRJ3hBX9QoKzpmq//elsIMHiZNwXlFp0+ GwvJEAv5NgIjkJsREASA93deUAP5xqthlqO/2gaAh7Q6mYEWSJNwpgswUGfbOa6mlwgbAHtj8AAq 0ALeagu24K1huwHMAAjF9wcTcAfl8A3lwA3cAQhyEHf0cAdtcQel0KYrdgUKAGz+ugi8EA894AOK K5g80APRoAhUEALYYAwIEKJ2wAU41AbEQLLt4FSRoC1gsABRAAYkGwZeEAmRkAUjugZhULHCZAyc awdZ4G46IAy9wAPcAAZ9UIoGUQIpeGV6kG9TGp1YKXAIN5twZoESKAtK4Ak74AnLu7wwML3UCwMb sLXUmw7ai3obsAHbywjp/3CEYRt72ou248sIY+sAvNAAY2ALAkENMmACMvAQHaFH9isQzrEQ3qAE 2yYQGXC/AGwwPPEBH2AEBHzABQwUCJzABGwFnWAFCOzAH9AJD0zBBGzBEGwFGuzAFPzAH7DBFazB H8zBG2wFp3ILc1AwCmGo7zAI36AFbFAB5yAO9EANjmAJn9AHcpAJ5kAaEsAGcokdWPgFOaIG76AF G1MOZkAdbNAFt+AEfhAJeSCyJnoCUoAH3lABjcAKE8AG1EBqjtUHbTBcATQ1C/AMStAGnSEDq8EH 0qAbHzIwKhzALJS/CsEN8YUBdCAHHSAOEvAO8UUKlnAOrYAMgFAHJHCojf9kw5twDhKCAeZAHeWQ CerABm+gDtOxEQqQC2JkVPMTDEPwB3dgCZbwF2zIC1LQv4PQM16AVE7jW7RhG1XgIbmxNQrxDunp BFtwCAOBB1PwAVgxFZZiFcJsFEhRAJFCFclczFshFZCyFVehFZGyDpniFKbyAy8SIwehBvIAH+rQ AR1AB5vwBSZgCRIQCn2ADN+gAoXzDpARkOpgAm/gCubwDRLgMhbgDvrsAefAKpmQH9o3AMvgJcqA UkSwBWzgCyvhC1J1A5eAdmg3sGKEqV6wNBeiP88gKLthCAOjzXTMNTCyEGowOXKwB+9AV4VTDvNA Cl+wCCaAAcdGAnUgas3/9HxqQA97IAeLWQHloA7MgAwR4wEgcA75IbpRNCAI4AUMZCYhkEqrtAeZ 4Ag9QA3wSAnxUAFXkAqYKgMIUAsy0AYTgABnXBu2ARKxUMIf3MAlvNZs3dZu/dYnHBIJoxBvwAIk oAAkEAoY2Y59QAokgJ9YqAZ38QXzwA4isH500M0xLA7nIAHOIAeAAwLvUAef8AZNpASgQB99sAfq 8A7hx0ZDYCYtBT8ycAObbQIUoAHMYAKtLD9+oAhSoAN+IChwPCgTQTAfzUJznRCqsAnfYAKbxgCH kCulgGF9QAIikH7XJjJ3+tcY9teOYwKOMw+NsAwZ6weqQAe3IAwnZ7hO/4AIUxUCxtAEfOAfx2AM H3Qh+XNTs5EFHGIbugHHYaAIkxAGXMAGYPAR3RYRvQAEdecQpCYFvMsQcyAM8VACEQEEPpAQvrAF 7qNGR0AE3xUMTRAmFR4mIxQFFZ5E+zMA/OEHfLAMzZAHkQAGVOAHXlACc6cAoIAzkjBGVEAFeYAA qPEZaRJEeZBOrXwEH9Q0xkA/9LYaH2QMwhQMuX3kIcFHMdThBD1ILSVvKDEEDHS6nnoSxHAM/sHh xbVEneQKfjBFYJ5SRNAGXD1jx2OQBiDjVGAAOjAJoBBEuRAMwdBVo3RSx1BKJHQLzMAN3vDfSP7n C8FHWTBD/KHhojQETf+NAKCgAGwQGW9AMnWgfncwAZPAAVsQ5C31C6+xPwSUA4cASiQE5lS0VGCg CH8g421uSAKga4dwCTrACqfuVGVpAd4QDQJgR0szSplh4LZ1EPpUinplUCUwB6sVDwoODHgTD3Pg C0CA7PEgmKyauPEgDAaOB3MwB2ADNsiA4CGRAxx1C+QwEK+K4DywbTlQAv1rEHz0DH/EBCM1P2Xi BXmIkJdAB/0lF9RRHvQwCbUwRK38NJqkU10+AHBEDEOQCw3SDSeRRmji1AhARg+kAbBeCyt4BvTA LiyORsEQhX9gQ0pQDmpJDdxgAf75CSIgDnJwn/TQASJg711wL9GADD7/wAPjAARf4A0TkLIZmjWG kAdn4FQJ6QXEwE1oIA2qMDbMgAfjcBB6de4SMLfMkFpKTw1UkBk+kAEA1U807wvVxAP9jQddEA1L fwvjIAXccLMEse7LYENeNVw0FAVkEtpHIEpIEEevkSFK9D/JxSHSkAVc0EkKgATwswWKcAO8kAdb kAvwbkUljqlo5G7zFqmfPOcgFAWsIAmsUENNsC9+IAF9UAfqICtzayXl0IeOwA3v4A3cERlqcCNK rCddgEzCoPVAkO3xIAWS5A5z5w2OJA60JwUVUAqXYHauIA+jA4eB6goTwALucA5X4ATqZ1WuoHZ9 IALeAAL04A6x5Qw5/xAHPvDrgGEJ3iBXaiAMRbYFv3AETFAF2YcN7m9RrctN3OT+8//+FkX/8S// YTCh3HQEaQAIALFFgwYDfyIdMcZEmZ9lAxxWqZJFYhZp0rI8o2hxwESLzyoaAsMBQaQB3z6dqGNO nbt56t6ocTTImTk24u6oEMFAgBp6pOrUofPmHbcuUoRRi+btSzxg5JxRe8pszyQVb9zJ6XMF0B0B KujQ6SPg0iRSV1wtEiBgEodGFBQwUMXClZNGE5w4YdCqjxlLe0TQkWOmR5p48XwJAzanxC3GjW/1 eJEs2Q94lStbCxfuhSkAlTtbhqdnWIhcpU3nChFp2Ag9pjZzgs0pFv9sLLWxLNG1RHfuBq8aNNC9 xDYWTpWGBx+1BNwKcOCoPBiFZVGqLYomXaITLRqyaBK4fVNjhpo3NpauqCMlYB4bE3LOiZNnpsIb OUWR+RrXa9O7N+rYlEJEAxVUaUQrDcD4ZYhuiPFjAGkWUCKELS6Rg5RSRDBBgTzAcOWEUBDhRQdQ FlHDm2ikqMAVVySIZh5XysqEuz1MAMKxxnrQBhIdIQFgRx2rOSCCNtoYoo0IvBhGDwD0iOWHcH5w 0rLWYkkmHGusISPLLDOjcrZKggiithZacEEW3n77LQYIGtgGgja3SQQCN+PcYBs7t9mAkW3kiAYP Z7hRpxFQbrCgRDX/zrlDDXHcqeMcVepwpw9F6fBGnnn26GPGeUDoQxVE9lDjukkaaeSSNqgAgwoO BFCRgyEG8MMQbAaYRAEV6DFnj0NYmECDSTTgRZIb/iBGGiWYOOYIZGVAwA8kVHCHFA4OcUUBE9zJ 5A0zFrPxsW50cSFcccMl0wUyx/QkiAiuqQaSEZIgxLUXXgggAHldIyRfU/Y1hZAArLkMNHgAAKOS B2ApY8wWlmiAN10aGKUBCGIYxU07IUgkkVEY4ZgRCEzwRoI9/pAGFDM2BEOHCgYxwxFHmHHEjC8M GEINAUToI5R3LKmggi4yjasRSUgFlhcDbhhigSEQuIEVA7ZoI5Ju//IgpplgolgAgT5YoMcDS2Aq hx5ACGxjAaX/mMARb8TpQiYpvImHgyYGqKINBW5ahBJu4un2sRXSeSVwwXWRpfAyFS6jDFgeqKQb BPS40hoooIgc4Cs1cKAQdArR3AHPHQAHBxzgARg0QqAx+AEwbRMuOORGqRj2URLZZpRtGNnAGzMU ScUbBcBAIBVeWMnDgHkqMKM7NbpwBxAPWrLgDgzuUICEeRgApA67WGBhHmpZcEIVCjRwBREn/sDG DyWU1uCGVFJZZBIDKACjDYfWQGCgSe44xxw1LpEBF9BgCC40aAhHqF8U2gC1bmiAAiwARB/6cAKT 9a0HfwscDAQXOP9wKWxMinsA47qRBNJdSXS8AIfm0PEIFrbQhS7cBTpkuDnOocKGqMhXMsiAJTJA STKSKU5tdIMm2EEAdttoAxjyAApLSIANi7gEC3QQDA10ISZfsIQluLE2c5ijAhL4hgkOQQJz0OMc alCFOiRgDgXI4w0s2IM4ysEMX/TAjjyQAFsmAIpLDOQSl+DFDRqhgUtwQAc6CJGIdNCrPm6hFrzg xa8mwIFLUGAsrfjGG5gxDl90Eghz6IUv+uY3DQpOFmUiVwsSt8pVhjCEK7jhDVW4QkzUEhOiEIUt dalLXNLwhuHQUg9/IMwfToETrNMN7CgGHDDIAAyRaF8dJGABS9D/4QJXUAMDJpHFcsjBAla5CT2+ IYBWCIAe7zBBJgABgrWdQB30SOcd9rAJKdjRnve0Zx15sAkEIGALf/inIgyQB4DmIRXd8AIYcuGF XCDgDwioxTdu0QtgyEMAyChBJzWq0VFeEAanNFcLPEGEarTLRzoawQFUqtKUwjKWssRlLneJiS90 gZcxrSE4mkQGKGQmM8kw5pdskwhw5GAau8ACI2RnxCV8gQ4y24MSJwETS5wgGwqogDom8I0vlOMN FyBFiZhXBxOUAlomoIcqDlEKOryjDmZwRjkoMYc6AsEHwIiJHX3AiySiwQ7tWAMaqvALJSwDGwv4 hQxkEAIw/EEG/+0ALDG68apn+AENgQ1GKsCwhTxoIQ096CRoOzlKH3TDBWLQRDWWBAAABCAWnGFt bHsEiZLWthoocGVuV7Bb3nZjBqDBzJMkkxlrAGAGYCBELKxUL+bOK4i3GWIMpJux2bkpBolghiW+ ECpQyKEC8vCGOUxwhwmUYgK5uIE3KqAGc9yhEU4wATsOMQFXSOIOh6GGHACxCBXFjwJ3EME5XDaB PGxhC4awwxqaEIIBYGMNdlhAHvIQghAgIBhhQMMvCrzZflKhG2gIwxCw4YV/yqAbwPPnFibhA2Rs wQ5oYAICVNFRMLgATBGIQCWgMQxT6EEP9VLSkkZQDU2IQQxBgP8FLDzhiSS3waQnpe0BIjECKO+o GtcAU7qGgwUX6MLLaWqABHoAB3CMIWMZ45gt1MwIW0DAGx1QByLU4Y0s3sEdXaCHBsqhThGoxyYm 6IAa6iAA/s6jDiJQAQP6MAFe/CEPFkhDLw6RSB2kggokzgMa2hGGXyTIEJBtRyQACgYvXA0Ml8XG MUhDYSWEYQ3twEZpIhEJTdvhxalJxRx6kAE7noAevRglOQbWGh4r16fH/oFkghqm2oR0pE8+6W2X jMoyyeIV1taF4GCw7ThhjHa028AG0hHu29kiT2m2BcfGwGY122ICFECECD7RBwXERRJxmcAi8j2B K6hCAGPbFQH/AHEFedznrsKYwyBAoQog9MAHPUBGJhqRCgPUAqBDAAPwXr2GWRk2QXkohQAmgIAo zHoNhkjNLx50WVC3HNR2CAYYurEFx+WBDvEwQCO41S1f5CEJkIucZQAwglxEgNlcxoKXlb5tGOiC 6U+H+rbTMe6pZ2wDMAg31cOdCNzZIh1sZnc60o3udqt5DLwowhiC4IQGjKExImgD30bZLSBUYA53 x3ve9b53vs8hDndPgd7/3nfCF77vUqDG3BtTASUArwnuUHzkJT95yld+lGkobC7WMAnKpyHxlgd9 6EXvGGBEI/JdYAKwbyEMUIhy9K+HfewrP44v+MD2t7c9EICQ/wLe7573vwd+8IU/fOIX3/i/xwVj 5mB62Tff+c+3kTBuQAoNICAOqbiEASSgDsb4IhbFKED4C3AK8gdC/OdHfwECUX7zh5/8p1D/++G/ /vabXwhCCAT+4X+K9Z9CCP6/v/8bPyGwgQIshgRQvkGIvAp4j29whUEABED4BAbgqm+QAGrgBkf4 Bm9wBAugAzYoh3Ogpkw4hzdwmQ7ogHLAgG+whDdQQTbwhlu4AjCQAMb4AhHpAWFgGR2YNQqTAV6Y AM3KhSFQAmWIgoagm2eogmWIgiZYiAF4hgWoiAXIAtj7vmLAwizUQiw0gvADvwLYQjDUwvQTPywk wzNEw/Q7QP/GKL0FZAcRCIVvsAB5EAdv6INMcARqEAcV6AI8cAVz+AJzsIQ6EIdsOYdyYIMuSkQ1 YAMMsIQueoNElCgLEIbGGARe8AIvSKJLkIRAkoNvAIVaoAZhQAZhoINLOwIlaIIoaJCImMIF4AIu MIRZlJXX8zzow8XQAwLmm7sKcAd3OAc56AA2OIdMsAR6KIcKcAaWUa8v+AIpeAcSgA8BoINByAR1 6IBzSET6eIMOiEQL6ABLuAVEGIBjORZkYQIkyAVEqgUDmIQJeBrgGagryAHGkAJQaAMkOIYGgcIp pEVsAEjJw4M48AVk8AE8kLtb+L51uD/x47/9E8D2G8D787//dQBAArQB+GvI8GPIALSBAKRI/5tI kPRIK/iBUWpDxbMEl5CDN+iPN9gE8rAzSqCEOwAER1CDTGAvb5CCt7mDb2BAl5SDLvKPNyjBc1AH NbiFReCCZWiGZfADP1CGJlCCYAgBXpAHbmCGEiiBOdAAijMaRVCFCuhJDSi1IlyGhogIs1kAWpS8 xcgBH0iDW6gRxvg+8nNIvBS/9tPLAiBJ97u/jPTLh2TIAgxMkszIdWBI9aPIhiRAk0RJXhwlSwCB d3gHOXCHr1AH5FEBdXCGbyAFQKCECjiecvgGD1gvQFhJKVCHRaCDc7iCTPguOWCDTXiJpTQEh4jK KFAGJjAG/6uchAqQA1dIhRsQFUm4jj46g4HaAhnwAg6IBkvgQSRoEIuAxQWwxc/Lxe2UPGBwhsjL hDq4A3mgA3fwgKuoAzX4BBPAgPA4FAswg1CwgPX8hkygA0tggS5QgwlQA9oMhfn4CjlgBwtYyqaU ymNQAiVAAmIghmAYAi+YuT9QBA1Qg++SAmSQAmaoAHaggFH7hB6ACrM8hiR8EGmwwi1E0RRV0RVl US1EQNlLybk7h655B7BAqxKUA284J3dggQrYhKsQhzoIBTlARAmSggwxAVXowHmQBwkYhG+4gzvo gKVcAKr8BQOogBzIgEnYgsZ6Jg6bABDwmeWZg1xxhUlAFf8doAcFwEQl8AM1sAAm4AIprELFk4O1 mABViKQvYIwSiAUr6MiQhL8B/MhBvcgC/Mj188j3M8yO/EjDNMAXjb0YHaVvYIATcIcKKAWdoQM1 yKI6oIegyIRyKIcuIIVGEIHyKAVxuNBDuINQuAJtDAUR4A86uAMQeINbcAJlSAUFYIE/YoMKoMxF OAQFgJo2YKhIkIEtEAA8YIFaSIU+qADqIIVyMAdXCIEjdEVZkUJb5Abcsz3R2iiuJNdyNVdz5YES 4IF15QFccNd3hdfkaz7vjLw76ANv8AY5MAERkIMTwJATkJQ9mIA3aARX4AYTMAH2AoQgJQUSCAV6 OAGE9Qb/YfgGergDJhWBKXWFJnhQMDgDAUjSG9iCIQiGYCCCNtCACviCXvgdRBAHNXAGZ9CAVGQC VmyIBRC1VJAGWpxFW1RA7gTauaPXueMBqGgEEkiP8ZKDPQi59lARFkgjNpgghKVaDCGBE5gReLqD K+DVPDiGPpCDW4gG+gGFUCAFFiCBG/AChDBHMHCHSkQGDSCsY2BFP2gGiMCIB4HFWQwDA/CGefgG VgiD1/MFbtiow9UofMI93QMCYHBc4Bs8w5sDhBOGyq3cwhCGwtDcwsCDzvXczkWG0MWDQfjZuUuD LrgDVxABUvBVrRCAKxAACYrdfyMFCdqDPQjNPjABBjiE/yuQoNrtg1ZoA2XYgiNIBTa4hTrgAEoQ B2dgBgMIBlU8wmZwiOq13mfAiIwwG1nEhn/EBjQwgHjQAVfYAy54vWi4goScPHdQBxWQgsozg0Pg w8qjBn4Th8pjhhvog3mYux4AgyEIAS8oEmVtphA4oGD4BWQtDU2kWSZgggR94GAYEmTNRNJgqGCI hFtQgUjAPgUwACpghfdhBYujOYcSkV4xTgQI4AkeEglxmijqg0agghX2ghAI2rnrhZ2bvBJQPdmb S9HzBTA4AiIJBiaISj+IAiYgBpIlWSUwBmNYUGIwhmNIS6e03iqwXmmIQilsg16ghj5QAROYhBsw gEhA1v8Q6IY/MABeUARFyANeAAVISgVW4IVaKDViQAIITtA9NoY93uPXowYW4IaecQZ6kABkoIZM iod5iAZJQAZH+IJ3mINbmAMpcIZFsAQNcIYuOAdmqIP3hQopcFwpSANvsIDmdQdm6IBBkAAz4IY3 eFKl7IJMAAYpEAcFpIZ3uNBbyMB5QAYLUMEvoIY7mDsfyIUFsF5YUZ8hHpJMRNZZUywz1seFsNtk hoiIgIgFaIMcUIAmCIYjYNAjOAIEDoE/8BVQWGMD0ICcOAG7o4NUcM5fCAYGzWMHPgYHboJjOIYm cMIb9ud/Zgwf8AJkrl6ojIJjQIKocaaMUyxHM7GMe6b/IWSCVTzi6r1mbb4FV6gCBEUWJ17QXyAx /b0DVSCIAvOnPwgkQqo4GSDZYIDiJ+ZjJaBbgKZpoBVoaXAIgz5oJWiDEHCmf5oEFgCKiK3dUmgL DuCAPHBpJDCGVURCiJCGbT6EKnDgjlbQIxgCGVDjQjIApzkDDci3P3KfPEixE2OFpokETSQCBv1j IlDAXlCGCqjpuYY9Y34G6kViZUBQJHjQSEIEenAHYkyeQcADIIiHCiCQIOyGxVqotW3FKsDoqb7n fH7gBEWCcW6DZV0iTnzHGzCaOc6DWrA4J6AGc8iECxgEatCAEPgFtjWGWyCGcsCDaJABSaDr2w49 Y86C/wFgQn1ugnSMOUKagEuogy6IhgoQB/GAGQ94AxNYhBtQhG4IBn202YeI6hxwhWVIUCgeggT5 5nH2gkjgMCr4gxAWYVYI4dB2NF4YCANQqDeogFro4ydGSKZAhkGQggvcDkue5TewBLnkAWDQUDkQ gV8IgwNHAF4IAUJaBKGZAEmYFnlABAPop1wIkV69AQTAsDUIhg6ghC8AghxIgxFPg3EocRLnAV8o AWdQBB7oBRd3cWT4hh+NnrBQBUAwgUGQAx2gAgMwAQzlgb7RbSRWgk4bgiLJxIZapDE2gEVw7kbI BkVAFdSIhIU6ICOmm4veZgXwAwdtg1wQb3/KuC595v+Z2yzyrgX0zgNWcLQ+WIT4GYuRnWdVdO+4 Vpt3kIdyUAcBcIcreAd6kAMJ4JlQYIY04AFyIIcSIIdxuIVB2INMMwYwoDhCMwDxiYRfwL5GUIBy QgA0uCwkUIP7poYv+E7GyIFTH3ETN/F1NXGx/YNbMPFe6IURP3QgiHWK6oEuUAc5EBoWKIy67BYf CIFlOIYGnWckaIIj5s18fuInDoYaNrEhbGoktlnqVUKJiMJtVgVjYKw80BXeQYAhPKAjQIKSHZII yIUtAMIzZQUwCGDxloFguIRv+INjOQZlwPcmuEBx4AZxQB4LrM/zPIFFUACz+gR5qAD+8Y56IocU pwb/7zgBXhAxDAuD7lWGI6hhdVcFCejJeKArG0mDjscDRyABapCC0XQENpAAV7C1AWCGOTD0cVjX hg+lAE+BWS/xHPCFL4DPle2bDBj2BV1QYzBCfoQVYhBnZUn2KkbCh8BeibDOZZgAemiEAfiFNNiD hGKrTOmARmjOXJjnI4gEEnb3NiB3197uBN1nJ1SGAUAVCTaDI5AAb6jJcrAAc6iDb8CACqjPO3AE BtwErCgHb4DTWWYDR+iCLxiEHpD5ccgPHwACX0i4NxDYUBCHb8BvKfAFPBAGZ5CHCTiEPQBZJ9gD ErgDOpCEPJgEQCgFUhCBvJ+AuMZMOYgDmZ91meeB/11jdWD4Bjm4AxPoAhD4ghToG1+gAiImBnvm xyrACOx1/uzFdouoiIywCInAhkYohUiwgFQgBh5gA0WIYwMABQ3A/klAgDYgBgi+57Vne352wiiA fz7gTXw3wizoAw0IgxD4AiToAr4HD38HiDfsTNBhR8lSJjXe5vWxZMaCowqWTFg6J+GLM1/kyAnD g0eKFG5mzFA6p+bLIDVvumSSsEdVqD0q+swTwYsXCxWASolQoaqREwUm5gk4xIIEKQYm+pgg1WfS IXnl1ImwEA1YLx7MvEUzk6mCsFtix4rtAQSIDx89fLFl26uXxnE85tKdW4JHiRIbeWwclybN3HE5 AP+PAwbEDbDEQAyfPezm8eMMbDeS8zvu8uXKGzNwhuzZjUOFEripcQSigqNN3xxlMuPtzTdxJOjI EUDP3BdmjuKN8xVHGDNmFd6wkVDuXB9v1L5QusQh1QRAn+jRMaGqlJM+AlwpWDShkYhJjRrdOLPI ySUFCgRcQbQI0RUF18/VKSdiz7cvZnzxiIanRC/klEAWWb4QUskLL+gBDzzWkPHDC6YQkoQ2DFrI ICQAjFDNAdeE8OEBI4wQwILWBAAPiXroYcowlQSBBRYttOCCLrosgcWNS+gIYyWVcPIjkEFyAiOO WDwQBJJFTiCBM1+cI08Fe3RQjgUVYOBMNOJYUg7/CObcYVImfZACQiYqvGMJNT2Qg4czXUgBmBTO ICPPeCaoYAIDKrgigjt7sCAPGyLY6Z0AJhQ6CBtv1ETHOd5sst0ii8hzxzeZlNMBAzfcwIIJyH1T gl9pOHOOOGERKJYv4cQSTjgNWmONqwFEWMMIANhq6wiEEDIMNNAQYooeACQxDK/QCHnsFJxUQiSM Oi7RALS6QPtsA85a6+wo2Y6SyLYQaDuKcmroIMkX5apR6WrnOCJOBd+88S4bHdwhzzl07KEACO+o M885FszjCDLkvDVOFwKUIgAgi7jSiFJy0OHNN3W8MwkFk/DCChWpGKDKIiZ04Yw3zrwDiAlydFHH /xaLiEMNNedcAcghi3DKAAsnmFCBM8J8QYcHFuBx6i3khBMsg69aSOIBubTRRgQReOFFCL6aYkqC saQIj4q/xhLLCwG8+qqsEU6R7LIwyrhEjdJCu3YDEECwjdtwezuK23Uz4ra2rtAzCQv0xFMHIF18 IYE53lRgBjeWONKFROr4qUAmllRQBxt39CHOVF300gMyFmwikxOLqKKA3qoAwoESaDDRBhNNfBjC MlxgM0QefwowwQ11TKKBepyaEIoqV5ygzh2IlCKHPH0cokYFOvlEAuXfAAH0LT0kUQ0k2WuffTXV /EKEGJ6IwTQYt6JoTTgBqA/21LH8EI41UJAxP//98yfzgrIRJBmjjC3o8oq0XuG2RLxtG9vYgAEF mAhGwO2ABtwGI2whjo99QQ6Z4MUCDDAIbwxCAsXxxpMsYAETnMYcn3hDHU6QiQtgIBPvMAc9TFAK bzAjDr64Q+jQM4FJgGEBxpCGDLJBClDIwAvL8MMA/MALFbCgD7y4hADqoICaLIIDInBFN5YRBkMM gAsLwEYYsLEF000AETdAwCGuoC42kIIeWugF0HrQDVl4oo52vKMnXGDHIMDCaTWwVQC4dqILrUhX L3jf1+SHSKPBAwA1CIEXkFSGMvSvBUt4hQAhAK24bSMRB2QEKN0GylFu4wtSoIY3MsGNTEzgEhD/ K8c3FOKIb5iBBZEwABjaAAoEGMAR7zjHPOTxCUOZYA+SuMIhGnGFCeiAAxMAhRIM4YU2yAAMqXBC KbYQhQFkQRpoAIMKNLAINajCJwJQACnUQI/bSeIIShiANJ7BhWWkAhSLeIcqwMCFVAjgDgygwB4E IAc1AIMc1JMjDFwgi4UqtKEueKgL+oeka3QvV1N7wdZWxaqNhkNChAADSBEwyAZBAQqMhMcIQnCk IPTPRjpi27foto1s4WgUBgSlAgBBCmowQwBVyMMXRKCQClRADer4xEW4wY1UHCFf7pDHCrnhAaRc 4QqL6MMlNDABM9zhJrwwwAB+MQkVWIINajDH/yb6oIEoKIELhuACGEygDieQ4AomEMEbHCEHFqjC BIDQ4hAMIAHWUCMa39grAlKhg2BUIQSNoMAiFNAHdaghHnFcAQxg8ArN/u8VC8WkLCpZBiR5QWov CMcPUgu/rxktFeBwQCEK4QBw/CEPioCVqy6EtQM9ABYvapa1qjWKtWULb6BcoC0Y4Yx2UcMJgKAD K/6QCkmkwhWDGAQ1sIsBNZDiEkFxxyYqsIm9muAN6mgEByYxgUVQ7BDzAAUvQKEBBITBD7kYQhWy MAAltOEI3TDAIiiQij/w4g8IoEAjFEAHFrRCA7wAAy+qEAZpBOMMHViEBZDBDTZFwxniAAUVZP/Q hAHkQQWTWEQHnJGDy24Aky6mEUQj2r8ywAIWD5CBSC3EWtaWB7bo+DGQf+wA2A6ZF+CgAhW2AIZu rKDJD3iAi37LLCLpKKYyBeU22EEHLfCCHqnYggEMoIEbfJkKxenCaL4hXgvcIRNXmIQr6nCOC0Qj JAxAhCticggn4G4SAiAFCxCBADQsYAghQAAo3pApCpjBEvG9wRZC0AYiGOMMYMjDITSgAUGjIYyG qMIyfrE6AzRiEtHNQx7+kA0OnEMOfWCYDr5w2XRgsgH/6ywmHyqjSdb4xlu4ECOtwQsHBPkRxj42 so/949gWAhXOdjYVfBWLZFC72mSjMragFQP/m3pLBEzixTy6MIh5aCDMjVBJ3xzxJHUkhB5vUI0j SGCOPcgsT6RQwR7cDQgnOOEN9JhAKi7BXqWotQ1Z+PIvwOCFXPxhC0gIhh8WgIYhcAAUOqAALygi AhaYwRFSnAQCkEAEMCT2DBQAxBvkUA5vyMMJqlAFKFjhiFkDsAEudvGMZsxrGz+5G91YMhWcXQgg J7vox95FkGP7bGcTIhn1S21qq50MZQE3phDYNituoMYvzIMONwDDHy5hDkeoQ0tWEocExNGBUKgA BHfoQAXucAdziEMENJMDIqY4DxO8Yw+ZYEYJelACZMhBPJKYgCQucQNQcMAAGgPFDXaY+EXQ/8MV Fte0VrPqHFYYQBEGuMElJMEBgWu1D+fAgy/eggxhZOCgK6C1LDy7UFkoVLSTvD3PH7CCpaMituh4 xO+NLQpMEL/4xh9+8dHBbGeD4wf1YxUZoPADqVMdW9sexbaX8KFL10ISqsgENRrRimg4OD+OkEAF RPAOAQi0HBcAgWSTsgkz0IQN5rjAOUrh9k+cwww9+P8cAIEvCMM55BQpTMAEKMJXnYGDaYB4LAID vEQdOEMJAME4SIEZBFhQUEM8IAMwIEMFWIwj8EAalEBbnKAvUI8PYBYm6QJD7VoZ1BEsxCDuPZnu 8Z7QDR3yGR8P9iAmiAIQNtuzgcMhPQjUUf/fkACXjlxftsQASEVCMCBaJnRApolAm3gDL1jCa6hB o7kDHYjAIagCPcjBHRQTvlFOvTiCDNGBOHjDL4HF/8UhMDhDPPhCHP4fWwjDIfzBkkFNNYHUH1ZT mIHBFpgAMOTAZHiDN4wDOUiBOgwCObgFXLgeDOhCQ7VAHaFA92xP91yDDT5Zk+Gg0A0fEPrg8e1g EA6h1N3Pj0CDi8DIKJzBWETDCjAC9mFfDCxBJMhACBjAFWSCPCxCKdyB4gxCPFADL7gC5sRGB5DK HbiCKqiBntSBHMjBHvQBJajBk5gABhQVSViAFNhhHLbFOPoCN5gDL0TCkqFBO6CBMqDBGqz/QTvY QTtswR/IQB5EQhhsQR5Qgc8ZACVoBKhIAR7ABQpSoozZkSZ0D/ZsD65sT/Z0gyiOYvGVYikSH/IB ofKhwpGtyo6ZiDVwDdXhiI4kQgOMAS8UARYwQiIkQgw0wCFcAoBRwhdcQiRsQSrwQiqMGRhEggJ8 gzeIQ2u8wTmQwCeowzuAgOnsnd5YjkPQQUVgwAmcxB3eYS9MABhEQQjkEhd0GhcQQySEgAxEQjdU wRrQIxXkAT22A1u2JVvawS8gQC6AwSS8BQr6wvTE0Rx5giYeAIdUlPYAQIYIJkRuDyjuniiCQ+8N 2RmcgZGBA6ucFDwgwCHtmPrISrJg29ps/9sAtaRLlkMFgEAtKIEBvIEq2CM5sUEFdEAmaIAkREMX vAEdnGN5iUApkIIAuMMdyIHCSNEd7MGXSMA3YAVbAMEgzEEvpAAydIEGtEEIsOMaGIMxhMF+RacM dEMkLIA6JpYx2MEztMFNIkCkGQM72oEhIAAC1ILMpcFdpmAcgYELEEE1AECw0KceyAqwqIgeaE81 aMI1XEMb9Fav5d4n6l6TjQAkNMj8OB/UpQ+GjECvYFT6ZNRIkmQDxACGtuQGMAICERC3dAEdmAED 5OQ7yMEbuAMpmMNIYNfu2AsLCMA8nIArzMMdqIATuMIVRAMP9EAviMM79N05qAIJvEE8eP/DBDjK Of7BEWxlG6ABGnABF4QBOyLBH3jBELRBxoDdFiAAGIQAErQBIaJBG/icEizAEbACK5BcNQ3BFugA N6xYH8DjO1CPL8CnGIyPX9ZKAKgWidzKCPhnG/gWLNzRoHqChyAoJIzAARwAiGSPbllIokLSSr2I lAEXFkSDWAhDNjDQAkFQcm3oBoSqCJyDAKiAO7BMF3BDF7CBa5DCN3DDBIgAHbABv2DAGzQCG5zD ObyEZAHCHbBAIyyCJPACA2aDAnRBBsyBD/DAHognEszjAryOIaxBMOTClkqDPNqBtnrBH0RCG/zC FvycDEDnGnBBN3iBEpDcHzTcEPACMPD/gFjwwOb0AJ1ugScEQdP4yBRMG7XFwkUFy4ZUgxeEDx6B ZxIQpq1wYocAKhEQwS88bKBOkow8VNqkzSssQQy4ZAzYwhiMwQNcADiMQQSNbAQh0AbUggEAgiKq Qh9UhQVVQCNQwSRIwFL4VR/UQR8oQCP0waspDAOwnytk1SQYGDXcwh6kQipQgReAQbVGwqChwdP8 Aju2A5t2wxYoWTAMgDGEgDy2IxpgQxV0QxbI4zdBEtiBgTSA6RDkQh4MQi+oBR7aIfWUAErxCie4 j6po1NZM39S5Yi5EWcEeQGHyZzUMQR1R0oxAFO3JQo0AEAzEwONmLAR4UjqEKihV7gak/4MtbG5y RRDngtImeAMiOIIlIIwOaAArbMEEruoeiIAA0IE8XIE8eAApqAILdIcqkEJ3qMAiGAAFxANckMMX lJsO6AAreAETKNkWhAFbStM0Ma+2quOW9lAYgIEh2AEaDMDE/UIThIE8km08KoEyzKMdVG8keEAa qMkg1MIEwBHQ8IA12MqKUI37rIrXoJbUJUsSxpgeEcFCdg8KBPAR1JFCzZ4sZBYmZZYCZ5ZnDpAD bYAtIBAoce7mcksibK7nJtc2SAILEGUH1MEevEMpKEAHdIAJCCsE9oGeJFgrGEVfBRQz+AJWOAMv iAMPpAUwxANy3oI4RFckYIMhMK0drP+B1oblD6NBNxQRMRzDEERAMHwIGjxxLoQAE8TjGsDjFXuv tmprO0wTXZ7BHvDwH7xBGlDPOMAKaw1SfRbLj5QNjFisLmiW7KVN7C3wZi2wAifCBsBAOiRCH+ux 5mbuyGruBG8oBh8yx2YDyIIDM6zAGLSCzo4OKciDdbiCwigAA9zoHrgCC8zDvbiCK/RBKVgAEJiF MAiDGXQBW5SDBnxDD6RFD+ABBygAEHzBFuTCLywDGpDltLalHWCDBgDCFIEC1FwxeL5OEkdCJPxC MHgBNlhxO4aAEqhjKrBCLcjAJaSBGoBBKdApFQyDKaRxIwHAAQys2VBs48ZxJSqwOuP/cWaFauZW rh4nAgzocYemAz6zJHKVLAVz7hhw7D8DdMd6bAuIrC1QD0KTxRx8jDM0tEM/NERHtERPNEVXtEVP 9HEm9FgIw1Igg0Z/NEiHtEiPNIEgADaogkinQdGSNEu3tEv7wCBodA8cgQKIhQhswYq5tE7vdEuX Ry8gQUyDtErzNFEX9VgAA6YmtDm0gVE3tVMDjTrkgjMwgwr8Qhl/9FA/tVaLNFJrdBrkAiichQFs wVaXtUt3Ab2KxSD8DFYHtVm/9anMQVJ/9CA4A1zfNVzHwiyMDV9PwSz89dj8tWAPNmEXtmEfNmIn dmHTgFjItVfPQTxENjDMwWTHQwqU/8AHIgMyxIMwpEBHAMMph7YwzEEK4IEwnIUwgHZqh/Yc3IIU ZAK70JIjcINl+YIPxEOcxAMwAMgtlDEeSISllIM5lEM5ME8ql4s3rEsmmAMb2B9Cf4EjpAAz3IJm p0AaAMNYxEIxFIARFEABCMEpnIJ3j7d3BwJ5d7cQgLd4j3d4h3cgpPcpCIF3rzd7B0J8h/d8i7cQ rAN8p/d32wCAC0ExJEBjuzX1MPcneMAXIEMfWIAE/OggkMniuIMJUIIifgMGnINZaWM5aIE22t83 hEIHfIM5qIEalEMX3AIDtMEhIIME6EAt8EI0+MIcmIE8pMLPGcAEWIIzSIA6UEAuMP+BMvjBMgzA AFRBFUQBEhzB0gTDMXCTNCyANGQB9QiDAcwoTtjTM52DWMTDFGw3fZ9CIJi3eRdAmZM3eYv5ere3 eL83eJd5fM93AeC3fct3fKd3evO3DYD3nKc3gA94gWv0F6iB5KjBICADLFGDBHTBHfSVmnWAOSBE ObgDBpgDBljCBSy3OVCCmllCWZ3DJsD22N1CH7ACJYjFOFBAHkiCHJiApUXCH8Rcl4ZALngBMyPB MUQBkR/5MzxDFvh6FgT7Agy7Wy0AQg/ILeAFIsZrdlvBOnQCmQdCJ0C7EVR7IKwDtmf7Okj7OthA J2h7t2c7gIf7t2O7DTz7tps7gK//+7izu7iv+wcQ+C2kwFxTDy1VwDxogSPMizhww794gxrcgTdI wTeQgq/S5JbkajlgwCaYgzlkwiaog666g4afwxtUwC28Ax30Ah74QDTwAiTlQi7gWB44QR18wiV0 Ay+8ATXsASuEQDAoQRNEQZEPgK9H+QJAKZQaAs8bgk7nAAjQAC3QgiM4wtAfPdInvdIvPdM3vdM/ /dBb1i0AQb0DDRu8Q2xcgDuMeAy9QwcI57kgAwugxjeoXzS02jmYgzrkanOXg1l9SaJkQiZ8wy1c EUg4gir8AcSmwjl0QSkswhemwg3ocGJIwQ1EwhAQQ+vs+jNIA85XwQK8Fc9jg05n/zVe3zXVa7QF eKE7mKg65NUXsIEifoKZDIIUqMEJZNgV9MEdVABLqIPDp71wp/27NLwcYLwr+MERHEEwHAESKMHD 5cIT6QAgOIIUNAICaIAZ4AEzHOsXlEIt9JcS0Dyv47xbTT7lu3QaVP3ll3XmJ7QldD476GqibMIb mMM3QFUHWEAp3IYcfEM5yMGiO4MAlMbWS7w5aPj5qwMdmMPt3wJAIJKmrIkyg02OKQkBihWVPKxS 6QBVC4wMMCaASakgAQ+vYEqiLBtQ5Zm0BVwMocSG7VZLly9hxrwVq1hNmzdx2vxghedOKzU/+LQS dGgxnkeP7vR5E2lTnsV+yLwFJP+aVJeW3qh704HNm3PnzNGxoMbbuQpmN5XqM+iLvEUkPNSxdI7d uTfm2Jgz1+EcG74Vbi1asGyZH8NRmigJFoKKAVCTvMVztuhPKlYIJrz8AoYYk5AjTZ40NNqQVZcs dHBbtDpeS1w0C5wSUqCAkFOxaa8TEoh2ASO0A/Fepzu4EBu7A8le51v3Kdk2dAuR7ny57OfSbWS3 8SGqTGBVTauhQweEOjly3pWzZELd3D13pHRRI29eOQHyzHijJuHctw7v5FCnAznoOK8vOdQIzJBm BjDMD8SUGAKMUnpwKQcBDOCFFw0uAcWAVAwwAIwQfjlCCWU+G8AkLlAqzbRb5Ij/hoNFKhDAG5di +eCU5G6jrUcjkgPOxwKCk403H6XjLTnepJvONutke7K222xr8jkruovpuxfVqOMdd9zx4Dw2MlEg FHoAYeabO84xQwI1vrGEDjVUkMCRPiQY5I131DDDEXUKZOOcDixQcIBDC1OGCWMkvNGHW/ZIBRRJ JuFQgwkaucEyBEbMBQww2jAmpCqykEaa0V58kaacWG3V1VdhjbWmLGHaMrwv76DDHXbOU0ccR6g5 h4RNKqjgGzkwKOccDCpwxpWsmFGBEm/K+aYPR/Y0JxN1ElzEkAEK84OgY4wJpo0QENhiCwMunWSS CSidYJIbDPgDgW4i2cOZCtzJ/8OLYwZ4ZoGBpUnVqjQGMVjhhRluGBhnuLxDnncopqMOd0B4p4I9 PHBEDjbkoMQRS+7IJBNz5vmmHBOQYWEeb+6oIORy6GCjwG65OKyJJphQwhgkghnCCxm2YIVDV/qQ gxtmBtmEL144RQCEaKiJ55BIjAm41IEbfikNaroOW+yubbUqkzPvcOecd+SR545v3vvmHW9AmMeD XCkh8Bx13DEjkzRLUeVLskSYBwQwywksZ2USQoKYYI4IJugQugEDAQP2+KLYL8Rh609E8tgCDAO8 ugKMYKoYKQuCx77lExpgjx32BGiv3fbbcc9d99ulaN2lh19kw4QzS9ljHl4BrP+gFDkqkIIENtig 2Es5zKBHBDY8YIZAMyqghx42bukBYxHeCGwBPo5BAgEVMGhlCy/aaCOXyhHIQ4B5uCnhC0e6IOGO cliQBzBUDgxeGEIUeHGLKyxjYAso2NhiYQUhrEM5UNpRbbKzG+MY5zjGOUVzApHB6QRiHceJDgdt UIwE+K4lwDPNG+jxDnrsiQ4eeIcIBPANE9AjEyLoUgdMYAFz3IEeKqCHGZChBgWooQJ3UIUj3uEB QLxBAmuSwy0EwgQk5CIVNKqAKybhBFcYQAb0YwUpvvCOO3SAWuqYRCpGdw5qeEMctTDGMozRBl4o wxDSeMaLQmEAORjtEpdQR0v/hDGFDzQpST0ajnNsQyRIorBHPNpRlEzonAweJzsqZOEtyiYVD5wg QHcoxX3qIAAFOEEc3zjHHQikhkx8wRtSYBoiGuGNLyDCDOygwx3MII89qGMT76jDHQ7pBD6AgQp/ 4IUraimBL0TDF7fgxbm6sYU/UEERGpgEL/6gA2cw4xK8KFYX5mEAJfhhJNgYQgiw8UCr4EEK0WDG LTLROxzp6DgFWMeRpqSdSGJSoFFCIXZs8EGBojCFK2RhCsBjlTswQI10PMEezpGJO5iAo/QwwR76 AAhLkAKjanDHPFTRiGgoUQDn8Ib1QLBDENiwA7dwwjFAoR4BcEBw8pgEGHIR/79f/KINXvBCLhDQ hWhMIBWpUMRLQ2A/DWwhFb/AxtZYxDUIzoKrXfXqV8H61SlwdQpTiMVZ0ZpWtaKVBp90oVW69A4W KGAPJDjBG/Zggj6AtALlWEQpzGAGV7hiD3tQQB0GIQeQmuATgJBHD9JgCXrUwW30uKIr+BACXkyA HpZQAz0UAKohjDZ+W5iEDj7FS2aQgwd92EIuOtMEPizjGWbohVVJY4gFjA1hn/QtC98qFTaZwwRs sIAHSkGKUHCUPVfogyU64IQ6VMACGDiZMPsgAhHcgbvcTdk3RACCO8yjpgo4xhDaIINUnMFdN2CF FyBHhBBcIQXimCNFtmARMP8MQQlN8INIAnaqMHCxRSnhbcJ+m+CwBTcmOZBAHyiAHhWowhsnAMQe SiGCOqiCFG+4givYcIc+9GGH8xCBR0mwQxFwdB7zkES6FiGCKzqCCl4AxRUO0YhJsCISBTSGMY4A BlWogQ1SMAMCPsKEYyjDMIciVWhOEobNhqEKYWCJ2HqrYC0vjMExsYQ37uaEQ5hgER/tgwBKMY8d qiN6ZyYFSZmb4jcXVgSA8J4GwMkFBRwSGSIARR4uoQBqYCAPISDGMXYWoVRIggO1aEN/o/BfkTwZ yi0KgwEkEIVudIEJB97yp1PVA4iZJhr0kIcCXGGJY5ZCBaUAhABCKgABAKL/D6RI7ohLYeERCyCv gLhwHQygjHnoIAwMAMEtorEJPCgRBIqA3xGOYRiRPMhBTR5JSUw1sJQUGBtoUIQq0PCMCnhhbPG4 wyCokW51D4Ld7W53NKJRDmqwOxrutre7oyEOpTqD3/32NzPGyW9m6JIZAC/4OA2e8IJLgRqjtkoJ KvCGRtxBBQxQgAJUwQIWXEEFKmCBCq4gAI73gQWqkDWsUa0AAXhc5CNmgAmuoAp3KJAKn5DDNyoA BoBVQTQoKbAhVhL0lYSB6EU3OhrQEIWF3GAAYWhdhbomDIbFAwitWdgchIGHai4MCHiwulSkIAVk ICPsYzc72cV+9rGHne1t/0/72W1ZcGYgI3zIiEcK5uD1OaQA73PAujD8DgQfpMEXQOiFMOKReK8n Ph5zAALUW5ICxSd+bBJIE8O6UOeIpqrOqpDAwqgxgUNQYmHc0AAL7mAVX+jcXMEgRvyMSoRIO0gJ xEDCidg5EpJUgfcDiAKimbCzCWC4D4oIRhr6cAkNpOIKJlAEAmoRfU4FNRfoMgAHPGSAGru+XB9B wrnA8Ic8UAS+tjcXqNGffqn0YAvmagNRFaUEJswfaMEwBkIQXZAmhATADDrU/w/lU7YpCtqgFyRg DxgAEZSPA/5Avz6lflghdP7AAPLgD8TPALqhDSDHGOSPA42BGI4ABH+MA/+VAAnGhg3ozgegjhkq gPDm4BbioULmwB1y4AVTQBJ0AGxKoDXS4AVbIwe6oAdeUAomQQEsoAeA4Bakbg54oCvw4AV7ABhu YQ7YwBUyATBuIQeEwRkygw0OTxgswRdSgBswoAusogdkQAlCkAkIwzCO4QiKqg2GIBiQQGhCIBfg CyQkDQB7L3VG4lCkoQ3G4Q0QYL1SQYDipw0i4XIaQRXOwDJcQQEWwR1EQAM0wABy4RdcTwk4Mfjw b/6ULBTHRhUswRF4QcfmYfnmyh14QRy4QQcEgAFA4RISRAJCgRoMwAToQBIMYAJU4QbmoQQk4Qrm gRqiAREksQ9KYRE0QAf/NGARDoEFLHERXAEUfEEenAEIBCAbTCANGqEcLgF8wKgCJiGldOAGvqAV ckAqfCAEloH/EOUNzcWojGoIciESuqEbyigYCkLa/E/3Uof3eG8B2iAHVCEYIiEE4GcOg8ELtqAW eKFSbuAS94oNhEEK8YAVFHIIQvDH5g/RGOcYEI0Pdib9egFsZMIZhCEFIC/B8KBrUiAJ2dELpMEP /VBciIGo4nAOvSAEFDIEIsGAjAFFrI0Pn4EkCDIHGMAPOPD2kKBc0AsMUuEGdCBE6uUGXKYUJuAM 3Ot95hAJbq9nlOAYmIAg8K8J1C8t09IHvGAB/BBRIKQhQ0AG6DIo4ycX/xyQRIJv9gDsDweyIF1h AMiyZ34MaMAvFRrh4pwABz9FKiNyEf5MBjTwCI7g9nxG/pggBNqAydSyM0GNLaUBURzk94IBLz+l crZgsyYAahpTBkhkLJnsv/5PIJPyEJ4h/xKiBI/gFyIhFVqBDgQAz3iBFWohD/LAIVKBFwyAFVgh A3+BI10PLJHgI5fMM61TwUDzUJohXJTBGHrSItTlDy6B10TMCeRlOBGACgxNyaJNNnUvKV2hCuZP /nwGyCSEFQygESgAFIYzIkDhBjwkFWqBU/QxFwz0qBayMsPyGK6zQT/JB3IhC7bTMAxCixTxU6jg EkxgHt5go2LIexSgEf8k4RKooKgM6AiYIPdGojargCxFsj7rUAbygBd04BANgCvDiAUOgRl54TjT ZQsW4Qu6wAwYAAG84BeI4cfk7xbeLxKGAAG2zkGlNFUgNAsOhUJ5RjHaAAx4YRH6ID0sYBPcoRwq QA3UgQQmQF5qgS7x0KjuyMkC8RYCkz3n82ceB5suRwcooBUU4AQUYBIu4QaG8w8GlAIkoByYCA+i wQAMKEk58RaCwQhVIRK+bkotVSaqdELFpXGGQAYuBREEIIa4gZ4kYA6QIevE4cNEJBIOtA2QIAre EzBblGfEkhO7zwt6zJn4s6lAxDIiMAL/YBIGwRE64Aoz4RIioUSU9Bb/fmHUFCGBLjVaYQJCQ7MZ HoRxtGgIaqFSJEEVMmE/qKELmEEKnEECLAFuFmECeOzZUvQPBQYwB4ATfYYYktRxjuCd6McCi7Op mLNfoy/6NMASzOAbAOEMrgnIntIET6eoDCBKpVVaM9UPjoFePfAIckERJIECsLICqOEbcI5MvoAb 3kABLoEiIiFUmAzA/jIHAtNWG1IGTpYjieAXQuBTtiA9xY8VJvIQgZUVVIANQuEStiBZEeAW1CD+ jAEPgAEZBsEZ4sHuemEcciAHemEOuqALKiAeljYaJEAc1MBbfi8XLoGMbgABOEAAnKAVFCEPWoEN +uAQ/uB08kAHFKGp//7AC/xAGrgAAbxhEHonB9IgcAVXcEsACIDBcHmgF3zBF8hB1NSBGXqBnpwB Gb7Ali6AGkzADAZh4AZhHWMCQp/hQWpvCIbKRP9AAygAESzRFfqGEs7BAthAAcoWZu/w/dYJIHkO MP2AXuUSDERHHzuFcnw3PZuJOcdvQP+ABRphERqhebfgOcmyXqJACZxBXCn3CxTVERyhHGSMDUpB ASpg8HiAHICAKkRAEroNG8CgZC8BBJpxEkBhUnQUFDADzxZBEkiBAjggD8JgDSKBBL6hC6QgDQBX cMdhHHiABw44cG9hEBBgHHpgccmhBHpACkDgEjggQzbkDkjhBv5gCP8CkRewkRwwNReqgCDUcLRU GDpD4GYPsRaIcwsqRx8NSCE1kRj4wMmeYYeTkgGUwVPAoBZuFgE4ZYAiQXKKinKIBvryYBIWoUa3 QBIUQBIsUQO6QVkxcwiOQQIqwBuMaz/e4Q3EIT0cQR6yywJ8YXzJYY15oAeowRxAIQyMQRVUAdVU AZcmjApEBxRUwAQAYREmoRYMAemGgA6+4AumxeqmNnAP+IAVeBwYOBqo4BYCtwR8AZLTwAfwgC2i gZ6YwRHMYRBK4RLmoQ9G1XOnNQSigAlsDwRNJAqigCB6xl6D5kLVZUR+oWeI4CNyTyB5uCBVQQnA IA9SQflCBJchBwn/KFNy0MshGQAIeEACJEGAIkEHJuASBFSLOREk568LviETHMGL9+wb5OEcFIAF 5OANiPUT8IC1SqAEDpgcesEb0gkN1iAM0EAJliEEOEB1KWACTqB5daANiC7cBIBcBwEZegCVpxZw eUALmUEY0hiBEYYKCK8XeoEHAleBe6AHEpij40EKOmBU4yEHfIAZUPklqnR6Q/D2Zk9nuu/2GhL2 guEY+HI2SeIZsmCnueAXckABkABXt2ACii9d5JAjQfAX9FEGDHR4ESBu3w+95jAnpcAXVBnRYlkZ JCAaaKkCkKEL0gPn6gAQFOAKUI0UTEAe2GATvMEbmCEDyGEcfAEP/yzPAJAA6ZCuCrgADcIA0fAZ 6ZQAEebOaXshJgxvjX2AGoBFAsxgDqLBEUggEgwhD/AgB3whahVYgTE6cX2gF4QQmgG3B+KhC2Ry WiM0MTgw+JgMXApDcijz9ohS0vqS93ZYp0sFGxYAGwyhDdKABUozD66ADuSBAla1DVo6BOKWU04W ciiTMn/GMjvRD6qgFlKBnYJhEYzBGdigWGzGHbghP7gB5yghr8iul86hWqRpENpZo3sBGaIBA8ri EOrYudwl0Ja3DrYaGVQyol/CF5DhG7hBc9xhD8pBDvogFNyBFDZhD8LADkJABLxBGBw5gRWXB3yg 8chBcEebG6iBG/9KVSZ6IBKigLmVeZ1UVGLFEkX+0cl8+Sh3OguwYQJIoQ1CgReQIA0+gZlCSgUA 4R3MwQCC0vWO4Dtd01Xl9chdVCQPgsmYwAQwwB0kAAnAuVgqwBF0qIkMBxBEwBK+IB7w4ALUAFjO wR3wI2QBrqrToHDj4QsKjp5sqQLS1YdqCRnwIKKZwRJYYBE4oA/AiwWMpw9aARQaAa1N4A4EgBTy oB0UgAHoQRwcDxgywKMJL/HSuI29gRLc4QvarbBjogfAoP5A0PWUQfeOsvdwd/dsOwt2+MVLZQAc IRLCoCGHgAfeAIafSQVIQQ7KYQ94IRcqc14XFCTHZWf0zyCyOgr/sqDZFmAIKuAIuKFwyqEO+sQb HEEczEEc1CETLr0C2MEM6oASUgkD2oTDJaALvkB8NZoc5uBpuZoe3EFpxIHNB8EbcgAIusAR4ncC tkteXGG85mECFMEV5uE9NrQOECEV1Ayto6FqgYEJW2IcgOCSCU8cQOAb+vYLPkGfYMIXqCCohkBU dJgkVD3VV10adtpUTGVrHOjkF8APKGAeQIEgeUAO2OUSQ6dylju1QXHJduYgCgJFUOTYjX0AEIAa QGEenAEJBgGcucEdzCFOjMgCutgMNIca2KwCLuAKPYBvMqHcBRiaeaAExk4YhIEZoqELLGHrxaHe xEFg34DkGOAO/+pAzd7hDDRUFfqgDupgEci6FAaLAQC/Ee/4lAprsEjAHUxgnCqXHHJg2fhHAtSh AqSwweSAo0oh5i4u8zU/8y1u0Td/0Tvf8wG/8+mYFJDNu7n4DUQApFxt5USu464g9jdO42T/Cmi/ 9jVu464A8EuOBVzp6b/BEdRgHuSgLNq6rcN8HvojE96BDRzBDMyBFFiAHswhGsI+A8ZVCnRpYCXA GeTAEvKNBegAGVrqBPRqAhjACRhAFcLoBO6AAqBxAlaDA5zgDjwgEknOGTPOFRbBiPbg1QBCFaB4 GZjNydHDmbcujiQAuQUx4i1fVCrJgAaGECFTpjQiQPBHWwB4JP9LmgQAQI9JeNZaumzJUg8YaNAq VXqAM6dOm5w2xkqW7CfQoUBfcKp5M0gQLDah3RGX6Y2lTY7UsXsj4cI3M9+8fTH3xoI7eSwAKdij LpQaZuN6kQMiRUqXCpS8ectE4lsXc9/OlVVwZY8JVXvulJowCUG3RQoUMJBDz8IdCk4WIeIwwQQL Vaq2IFjk6pCJPeK6qJNnoYuUNDzwxCOXoQcwiRJ9gREDjZCeALzDddSYRNtKeCgBQBox4sC1AyOK j2Q58nmAWJwiLMXSwoWuJdt1eV8CHgsWTuTLv4iFPtYU8ljAr4AjQcIXcKOwyHFnJn65Dufe3HHU xUKZVGBOHZn/0PGJOXTMMw8gHYhzxxdAADMINV1QY4EJlDgTDTVyUEMNMx3coAAL9Hjwhjx9CLAI CyacUw49jTWiCiIaTLDIDaxMwAAiqrjiihOuqKBAH62cJY8lFTDQBzeOcJMBD9Q40oMvPQAxDm0Q +UIIJ8mEY5I1P8TygilJADAccccdkMs1ubyZSwjD1KDHbryVydF6nFQinngttLBde+A1sEQDfQZR SXmK8ikeeLw8sAIV4ASxBBZfUPPFN3x94w4ddEnwDTKD1OFOHYap4s43oahjzjnemCPHG44AM44U zEggRS+ydRFNFwIocAg97nQwz1kmAELBPOXM840kZ3Dgijxn/6nhjgh7LNLIIvLIoYKNoDQiQCnq dFEHg4uEwgYdCpTDQxo53IIMJdRIoSVEPUAB1A8shRlAmdoUB0lxepgyTCSV5ALNMMPQxDA0nOip 6MPs9bmEC+AV2kADEGRcaKV9fizoEqOMwgh4JI+8BAITeOOMJWywIccnjnxxTgWOyDGPGmxUIIEl 8njwzSIMzHPHG/PQ4Q0yczjDDTWDjANXPJQosMgETihQxzuO0SNHH/OAAIg8V5hAzx6flLKHHN/U YYEcJlQA9zkgXDGPOxWQ8A4g9ISyiRONADLBFXIMcss4afQSTSaUEF4vOeEEFc5LLFkTgG8HhHDA ATUcUHAkDP9vVGfoIwxDHsQRK/rxxd5lzHrGGzeAssgjz0577aMgQ40Gi0jAjQSZeGPBNzZ/4Ygl aqhRTgWfnKOOGvPs0QcppGRyDgbniOPN23iQ04tbyJCgSh2kqKCCCVeU4o4AvLDxhSqH0GFCH5NM AogJ7gAigTPOfFFBK05YkomyVQ0Q5XjDO+ZxGVeQgAQmOMEeeDaHNHRBDnSwADIaF44fhCMA1ghH 5KwBHUKEIBdeKGEJEZabjZgiAKELnUbIxBE8ccQUpZuYny6GsQbEIBExsB0EaPfDIP5wdokYBQbk cAgNgEED3BhEOSQwCEo4wh1qCFA5+iACOvQBEKRIWybkYQL/OrzjHHIwRzksEQ1kdK9W5+gD2VTR iElwwEcmcMQm7sAADWzhF14gxhD8MIRI1IIU8yCkGb4gh0ncQBU1W8QlEPGOb1igA2rIhAkYcBZS hMscauAGp1RADzzUyxc4gETA0KQm44xAE9doQxsiAEsvpJAj6PnBD55TJ0K8IBk/cEk4yECGlrzg POuphFL8BKhXKFMXrIMABDawjQ04MxEQ2MY2IMCIa1pzFNbcpjo04AUm8MIZrfiCNwYRIDaIwxze aKIjvsEGA6riDpYooDccQYeuyEENeJACHpARDzyU4gqA6IM3rrCIVpRjAoeYQCSk8Qw+RAEMkdjC AJ6BDSaA/yEVKmCDKy5BitBMgAKAwAAdGrHRVFwCEKqIhhTU4AREqGYeV2ABIlhghgoAIhr1ukUP RmDKoAoVEtXQRBuIgNRXQgMlJKmcBzUIQhaaIhZQhQIwr0oGWwZlT8Zcyp9cACjuvAIGGouBM89q zbMmgprV7CYj3sqCT3xjEOIAhAcYMAhHOGJAXfnGO9RhFwtYgg4ecEf81NGHO9Shgp+Qwzm6QI5x zEECfdCdAOBngneIYBJHyII0UsGCVLjyF8EwRBiUYYB1GUAH39KMAEwgAhbc4AquCEUHBKAkRNxg AvSoJB0MIwIBzIMEBo1HL3ragxmgoBpBrUY1UIACTfxCDP+eqK4nxOAFMKBEJZN7SUsCYIoX9LIl VsUqMJPRpUp4wTpe/ep3GqBM1zkzrbKQBTW3kc0N6Leb21CFBZgRj0F8Y4+X8AYznAHFvFbgjBV4 hzhUJQI2mAMsavjGN95QKs7EYRzkAAY9WFCZSyyCbr84BhNykQpQpGIL3YjCM5CwADAIVwW8oIAj VOAKEShAAKSQQyhS4QU/PKMK2AjDEf4wiT68YQIacEUfTjAPEZDiBB7AgCXEkYZ69aAbO0Cql718 BOtWVyliaEMkRrCbcMSCN8MZmHi9C4XyahC8NTDYepUShK9abFAbi4FZzbrWUTzzrdokGSNswYgu IAMZXeD/hiUmsYUzfMECmXjSFyRwghPUQR57OAclhOcN470jE+iq1h7cEQrYWoIZDFgEBSYwgUYg oAm/6EYtaCQHBoBBCQuQxgAMoQHBzGOxV1CFCligAANE4gaSQAAXDNGENizAD1zAxgDCwIQJyEMF i2BFI1Rwh3eEAgQiqMMctNwNWbjAEy5od3XBCm+wjjkCXmAOAGL4guc09Tc+saUthwnClaDkABF4 QBBg8SdAvfcVzUwrN/GL3w0wwtBvLYc/0ygOFhjAAN6ITwXYsJUC4kwANS3FNyzZh3O44x1QvgPX SKCAR6rjEgaQxCGuAAZjGIAXeaDCDS6BgUZ4oRloMG0k/1iwCFKU4wSIuALVdvwJzfDiGMeoQhUW 0AQlKAEMk5CHAfwABjogyAmqwFYpHBGNh2h5BTBwQX3d7nZ1wz3hZTi4JqoxgiRoJLzDPM950JOM F2hk8J4JE0xKoodIeAEWjMeOwgelMY1BYK3bEHTlR5aIbSCaEWj/AjN41YoQTAKdHXeHBSghDjPE vAN/aAM16qAIcVSgAya4A9XITgAWWEISl9j0JAxwAw4YYgB8GAIvJFEYDWTdDwuothco0FAFmKAc 8qBHHzgFLETIAwxZaMIClkEMJziDBDcAhAZqcYRl3MADgLgaKergDQ4jl+2veHt9397u7CQcFkFo g3NHUP8DPhELHkSAUNASvoEAGgEGYLAFfwAT1hBnkVMSRJULBocdIQN5sOM6ljcKS8AJS5AIjKBf tkAC88AGePAFXSADxPAGddAFebUf4pB6XfBgBnAE70APdCAPdVABdSAkrnAFpEACe6BIGtAKusUK vJAKYSANuSAC82AB8cAMlOAOrHAMv+B90sALgOAKoHEFpuYypCAQchAC2BAJf8AAmRAN3hANWiAJ OAcG3dAEQ9AIJ3AJGnAIe9AFXxAPawcDylR/7SYL9aduugBWf1J3QeAFIVAD4UWA/maAAQcPtUAF kgIO4FCJqaAILtFdJkEIlcB/F9gCOEQosDMKplhEQ/T/cG81AepQATTCCmBQLFRgAB0AIhWQCe/w Tp5kAEMgBxH2Dh2AAWJRARZQBypAAYtwCI0wAfPgCrygA9F4BG2wUaogABpgAKnAAQgABjJgDMsQ Bdl2AnTTNefwTpohEKCADVlwBKBQCgwBItTADczwBgKgA8YwAAtQY0g3T+rQh1rSAyuQDjCgC8r0 h4T4CvmHiIwHC5WQES+QQT8ATJzYXbxQCBeJkWfACuCAAyUhiSTxB2CQFNeBgReTMbPTVpNHeRtg C8JgIdHQCpFwAXSAAHnwB7XADnv4BV8wCJvAFVvwDFfwCSfwhO9gP3RwRT4Sa4ggCdmwCLygCKBw CSGA/wYL4AWR4AeLOARIkAuRQGvc6Adt8G2HgAh3IAACoALyEGsUoARhEAZ+gAB6dQ69Qg0o2BW8 4AW8ZgyLIAeXwAukEA3npiU+IJAHCYiDKAu6oG4J1wJ19wCRsBEk4RKR6F0OUAjogJmXiZno4AAO cAaXyArCQRJJEIcrcBMGR5IUY5IaiJL4RWjvAD8KMAneAAq1kAqpQAqytgiXJgFqQALycAikYAHm YAJ1cAWUUAFjwSEewAEacAmS0AiIoAIVsAjNCQo3gARZkAvHEAXHoATdkAtbwCybwAYscAeIYABK 0AbnUgF3EEe/pwhDxgXSwAo3wALOMBfusIcTwAsfEf8JyqBRjbEH5XBBa5cOgFiQCTqIh7iQsPAA IZAEYUKZLsELlrmZ6PAIGYoOu3ChnekAl1iJl7gCpmkTNoFnqWOSQJR53DQKOuAEX3AICnADYLBa GsALtQAGVHAHqfEF6kBB6iAO7OAB5qMAfVEOzDAIzmACk+AifbAH3/AJNJctE3ADzLcAkbBsdwAI vDAJwfMNVzA/rCBtYZAHE5AKvKACN2AAqnAEVZAFhiBR1CgDCBAkknAD/WkAiqABiuBkrjAJjXAD 1GCghgmIgMigZVAGjPegM4BKkukSOFChmJmhk0qplYoOGFkIqKCpmkoFNFEeU6Ae5MEoGNiBLEo7 0RD/DYdABd9gAGDwB6mQhDpQC7wwV0jaBc4AK29QDt/gCGDEAnVjAp/ADvTQfh5gjfwIJKQQa40Q CdjAnU1wBKkgAW/QBx7ACzmKAKkABgOwDIawcQYALUI4AVmwBkWGdUpwBLmQB/W5gKwgA1HQBhqg BncQCj/CC95goIWqrwnJmIiKEyGwBaJJkZF6oZVqsBp6qRe5qZr6QrykVURhQxfTgToUgpmnChJA BxNgCd/QCDfJCjg6CWP0DWqAAYPwBXTABncwoMlDCkapAuegAK1wbOAzCQrgCgzFAhNgAJOgCiJA W3lAZHs5CQwYAhrwDhOAAMRQbQsQBqngnIcgABVw/ylmCQqRoATSEAZoIA1KEAwDwAVbdwkiIDRX g0l9YADisHYbsK+D+AotIAv96q84sQJbsHG1UAvggAoWerB7i6GbiZELSwhU1RJkEJE/ALGNIrG0 00MGcAjl0A1esDLR8E4VsIfUYAlyIA/egAGUcAd3MA998A6WYAbeIA7FwgCqUH0gcAcXUAEnsGNq 8AUtE0egMAEs0AgaAGlhMG1DsAzGQEKlhbVKoAiuJglNCQq4+zbfUApdiJ43QAet1gg0og75MyqN cA51wHNfkK+Fipj3B7eJ6qCQMqJUsKmaiaF7y7cJq7CaCg7JgFW2lEFEsR6IazunSAEk4GlLygsy 4P9z4jBpFqAKciABm/AJmVAgRPIO3BAKnzAPpcAYgDE2qkAKLJA27CBuzMADPCAMrsABUikJtcsi qeAHaIAG1lYFSFALGkABJhBlk6ADvKABP4cYdzgJoDA/HBAsrYAjjzQPnDQIvtALPBANquAM9UKY B6pM6nZ/b/u9ipoTI7qwmnmwq4AJVWzFmPAIolDFonCpC4sK4CCRwORv/gaxnEC/o+BnswMGCHAD F6AaUsAAeeAIQzsz5lRJ38ANuBhGmSCDd2ACluAIakAJ7+AKb/AN9FA0b1B7amAGzGAlvTAO1KBb uKsBMTwJIjYBHfxzh7AIoKCEvHAJNxDDogwKOjD/CbygppfQCKDQnDfQCKXwBl+QAjwAxMIgAsiQ JWmbxEucf2XQmIgKzGWgEyvgxRd5oVq8xVeszFfMxesLDr8ETFBQgIY7FHuCgT3UQ0WUC20QAmCg p6ywB3vAASHbjFeWKbBiASYlB4Cgcn58Ajv4BudAB6RhDndQAW9wAudgBmoQD77gA8AADL7ADIjg BKCcyajsws4pCRxwhxygAxrgBJcgfZZwBxOgCDcglYfQB0EyAaF8A38qB9zjCyMNxCM9fwepmIuJ iMEMzOErt16sqcaMDsi8xTS9zDUtCn/7xdCcVWRczWaMuIl7ijKwYmCgA1dgCY5RAaqgCN28B2Yw /zNrg5aItTNG+SPWWI6YywbzUBb0wAYiQA1W0gOxUSWMNgfxILaTcBl3GC5amsnN2QgeEA09QA4l IAUK8g7uIAFdIAwlQA6+wA2ToAHuEEHkUCUkbdJGTH9KDHdlUF1E8AvWBQvg+8QwHdMzfdOZzcw5 nambCg675NPJoCdOQAgdKNQ91IEL2A3cvAVE+Q7yIFd18AkGcCFdkAkYgIvlwHImYAFmIAImUAp1 UAfFObJ34DYioFeZYHG60gPN7QvecAL97As8UAIlkAZz0AcqcAl/4BncXVEg8QcbdwPnAAzxcA7f cAu0TNJZJgxq8KeDoN4k3VOE2XaLqW7VtVxE5f9cKHANOlHZll0IoiDgNr3MAq7MnL2wDuAbXVIe JcoU9IIH2YAFaNxDQ7QEf/AHIeAFwKcOznC7eyABbOANf0APEnBGZmAG5mAJ53CEHiAO52AC7ycP dyACGABFmmXP5ZBZ7zAIzT3Wzc3cPg7kznADqUCJW9AGwRAJqfAH3RAJ3JgLCCADXhBICAAK4vDX aSAHV54BbXHYiD3fi/22ju0J+T1UkHA5wwzFMB3gmDDgN/0FOD3gXfzF+fKw1IEUHyOot+AERTQK PORnSxACMkBROqAAFQACahBbu2qyoKCf8+oOJJCGIuBAqrAZUWYCZcTI81AByHPe6iACaoAMYi3/ 5KReJVlmCQiwBVSwBVs5BFxAwuW6Ud0QAv6JAFQQAkt+QeTAA0CQAd2D2PK9dvW30p5wd8w1VACA HECFHMdBzJaNCphtxW9e4AKusJcIVd6lZlxFMVgADozAC0WABRPHQxnTDQy4Ps7AAOwgGKrgAblI nZNgDi8uAeKwB+ZAD9IpB6XQB6SisnRjPPTwIgNCCnRgCVJg6lZC0selDmBwBL+wgGjQDmsAdlmA BmuwBmhgBwuAAL+wBVsABji6gB+RBwpADrfgDJPwBmkQ7L6AXN3Qdi0gZscuVMZx5kE1A+QL7Rep xQPu8z9/qSBKCNnuXR1EHSRpkkswBuH+AIwQ/wMZQ42K8Jy6NQnncAiXUAskQA1IqwAS4AhmYAGa +4XEmTUq4A59IA+kQA8qwgagYg4L9g6GHNBC3twl4A0awAoh4Lte0A1IgAZ+kOtYmgtDcPETDwpb sADtYAftwPiMbwdrsIAywAqXQA26EuzxoHa0sWWyUF1i8Au/oAk0b0o2b/M3PwIj+uxefImoEOA+ vwjZ4AA6AA6b6Ike5F28cSdALSi64Gc7BAG28Odr1QByIJ3C0gepsACu4DTccAZ5sAhb0AhfIA6B 3AGAcAf5ge/PcwJywALyIACugFtkFAofJweO0M8+Dgxk7QsaEAIh0A1hsPjtEAa5QAxeQFpMQP8M bpkFNKrxGB8GGA8Q7QQKrIIACRhFzsj5YtjQ1y2IESH26LbDU7VqIwCMGGHqBQCQIUFCIlmSZLUH KR+sYMmSCjgqL8GBwwEPHo5UBn78CGfNmk0AYAjxtBbA6NEXUyphwbLEaQyoiaRuSxRjG4QlKr7J 6VMrBClugLI1OmPpzTxLBjwMEsem3KY3J9h8qkPqjoh5Kha5ctfHBD138eJdwEOuR485XYR1GVQi TbwtbYjZaRfGj58hbcKgURKiTRMvXiKlQmJnzYJIkcCoBhNmTTtlBv5s+cNtnMOGEiX66OZCzLAR evSA1PPihSnhw0dCqnbg2vNrKqVLb9ltBCT/m9bC7dyZLFy4ACDBQCMUq2fRAMY5LWXq9GkDCBCk JtpGNYazeWdqednCC4ErDSqgRIIuBDwEFAm+eYeOQahx5I096FGAAldEEMEEFlSZR5w75pHnHTV6 6AUIPIDwpYcS1GBlixBC6GaAKJQYAg0a18gskj/+yEUGGboBAwwaQwCjRxmkQWONNexAIg8wttiC lDQa6iE33SYCw5M2qoEkJD0C+C65AOABgDnn2vgFFjTTnI46lg4YAR5ryJBTzp16goekEUKohJMX YoklqfVYAQeqBgqFb5SrGNlgA6qkgoAZNUpRhQUNEHnDhHKooeabPd6xJBJeVFHFr3nYmacP/xFI aUUBRAQoEQ8T7rjjhBP2UKGLW5Bh4QRKKgBGAgSOyMVJQ7gIxotl1kAjl27QyCKVPCIZAgwEtgDj DypYDEMZIY1pxw40wEglWypY0cGZXhi6RY1FqoyoBzBaECMCN7fskqcAhANgOEjKJEIMTzyBJeCA YUnpmgOca7HFem1yGE4xORrhAC8eCKKSSoIIgimmYsjmFl9YWGEMqLZRdFGTt1k0BjNUKaUUMEBx xwwzulBn0zpAaeQSDSSo45MO3CEhFA82uUOFSVRwpgRfeOjijj7omMeJUlxhgwQFLJDAFydkQKAb Q9pZI4oqfnkNDQTykMGLbragIoQct/iaGP8cWwsmEi+oZeWPEPzYQoY2jMlDgTlu0cAOxA1wF2Qw XAhiXi9yAa5L8PIdc6MD2vAkiIEHLhiWa6pZDs+EDxjTJOzu7NcLjTXmGIsWWtDFKV3G4AUiHsBh ZD6pGFHZFkZ8P0cNZ96g541MnDlHHVUsaBCZLgzowxtL5hHhDVJKkUMBVa5oZJJS3HGHHlcmmeQG Ds7QQBV6KvBGCjUUmS0XygyJBHBs2kFDtZi6wQZxOwzAAGAYwgKOgQAqgAFJ2ECDkJSADRnUohZM CsYfkOGEG7jDGUBYHER8cSWNRQBj0OCER0xhlOSMACOaiADA0EQw0F2HJKMj0wEwckMcXkP/DEEo Q+xagAVdBHEJs2tADEbRgDH8ARxBuAA4xhC8RUHRFrZIByMywQ15qKEVfeiCBMzADQmwwQQCEIe5 zGEOE/hFBN7bQx/OsaBUucIEk9CAJCahCh2wggq84EYaxnELKQwQAcFQVtm8UIUwtGEIQ8hDFQBI GUb+wQtD2IIBELAj14CLCapBoAysxSNHpGFKh5nSQ9zliy3MS4ScmEIyvPMDV/7JFKbgyArbEASC BSxvyDnd6KqhiTa8UGC5DEILXHBMF8wuiEGEQVSiQp9tjOEBTRwD8DYwReBtIx0IuME7nOEKLjoj E2+oQB0YcAUwNOIbFejAOShhAlcswgn0/wCBPOLJAleoYhKXAMUlGoEAecRDNtXKAxXwpgQCLiMK v1BCGPT3owiEYQu5CMEWVBOMgZwNDNhAUhiuZS0nNUlYuTCAD050GIcsrhc4GEYu9hSLZPzAT+Hw E0yTEQtODCNhuYhALgXmhQMkgTinK8kviRCwHvoQmcd8RVODWET5bIA+89lAOjagqGja4prAw+YU N8CLCZzjDgV6B2BUIAwpIKAWFXhHKQRQCuv1oQ97UAALFHAICkzAFa5gAB3ksYgbgKpw8zAAL3jB pCFZC0nEyIUXXCM2GeQIDAtQgh+UEAmBrIEJkYtELp6BpHa0obPdMEAbEBeGIaxNAykgZf8PgJAB U1aJHBEjBCfM8x3cfqc7OIVGJSKAS0+4gGC/0BLqioqCgBnzmLKQxTGD+AoYNBW6MKDufOpz3UZd c6td5S4jvmAGAcwDEOXwQB/K4Y5IIKAOYVGAAK6gDjloSA7uIMUe7GqXPqjinKD4gwa+4YtxUOMG oADFGXgBBiXkQW5hc1ZnhvAacP2hSVvoRhaC8WBsDOAZy/BCCIawmdcsIDSbcSji/AAGVsTjRL3A Qz856C5yWGNfehhGeb5zW9y68qZTWA9Tjhm7gGmiuMdFbnBdwFzmOlUXTq0uDBaVjkQ8mT6+S4RV rxm84I2CEdjcMvAYUYFvLEIDW8gbKy7/cYIKDGIQJmDzyywEtXOcwAN16IMTFoGIPRyifKzoAg96 kIHD4KEcizhDKrbABEG0DQ1iI0aH25A/xHkBASEIRhtCoIxfhMA0CzhCG5SQBdCKTVlh8MICvmWH MHRjCJPIQQ94QA0EKIAHi+OBNfQAj+R4ZKY51nEyeMyU2C33yMIlxhGIcNSAIRnJ1GV2dJudCBhE mSoqo4qisLxl300xeInA9hi8/cRtvEMRqdhDBdSghgepowIkeC8d3iCpPdRhEYBQhSuuwABXAIIF JpiHOwbxBl7gwRc+IHgGMuCDXjDDABMVWy3CQJkqEKMbeHtGO/zwBwQYQqIIzgWQEikD/898FklV UIIxvDCAI526MwbYpxRy4I0t3CENtP6JT+CUr1ybYgpT8BOPewzE575CF8omurKbfXRoU9fKUrUq I9Lx9C1fdVFVxXbwpijNIjjACbtgxBj6zYJ5HM0VraC3AO6ggEXIk1VOcAUiXNGIPgigFfbdxMF7 AAwgAEjgro3GHpxwAg0YoBapsXQeHLqGMCihDTLIAjFCwJ88tEEZC/gFFZCwhiN44RfY4CiSjhTq R67BMxSthSKY4Q0q9GHm7uqFIvTgE9g7DCTDwNjGXrdMXTj7FbKAAe+P/vvfL72qUJ56OrBpfOAh v8tc9bYtxuCEVVCgEdnAwhgaIYlLMP+AHiyYxARUcAhE5HUCe3HFXVUggPJL/w4s+EIPfJABIMxh Dr5QAy860IuD+yINKeDADfqggQQCgyP4kdcQGxpZlglQhUMQgEvouP/xAxnorEkaAGyYPC7IgpQT CFT7ETCgglrIEVe4hQkwADxYHF/4g2F4PZ8wCqBoqRbysWTKvdwDvuCDgadLB6W7QauqsqcbPigb BQhYPq6iIu4qwidqhQtYBV6opnlrhAqxBG94gz7YhFJggFFphAkQAETog/NjgEPgnnnYuxRABilw BCk4DB6QAw0QOJPCAw7ogxRQA0qTATBoAz8YDUKiDHCJNXdQALkBEmOQGx6ZOMILhihNcA0keY0O U4K2+YOC6gZFkD9eSAUfOCUUvLXYG4nM8QRgi0EZ1IUYAMUZ/L0NqC6pcDIpq6rhezKrSgeVYRQh BJ7ma76t+rbgaT7nCwgAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/ap.gif R0lGODlhCgAHAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAKAAcAQAMk eANy7sEEEeID4JG55TuGABBHERBU4RhjMZAHMRQEYDjbHBQJADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/content/vol103/issue20/images/small/zpq0190621720003.gif R0lGODdhyACMAOcAAAAAALGxsa+vr62traurq6mpqaenp6WlpaOjo6GhoZ+fn52dnZubm5mZmZeX l5WVlZOTk5GRkY+Pj42NjYuLi4mJiYeHh4WFhYODg4GBgX9/f319fXt7e3l5eXd3d3V1dXNzc3Fx cW9vb21tbWtra2lpaWdnZ2VlZWNjY2FhYV9fX11dXVtbW1lZWVdXV1VVVVNTU1FRUU9PT01NTf7+ /ktLS/z8/ElJSfr6+kdHR/j4+EVFRfb29kNDQ/T09PLy8j8/P/Dw8D09Pe7u7js7O+zs7Orq6jc3 N+jo6Obm5jMzM+Tk5DExMeLi4i8vL+Dg4C0tLd7e3tzc3CkpKdra2tjY2CUlJdbW1iMjI9TU1CEh IdLS0tDQ0B0dHc7OzhsbG8zMzBkZGcrKyhcXF8jIyMbGxhMTE8TExBEREcLCwg8PD8DAwL6+vgsL C7y8vLq6uri4uAUFBba2tgMDA7S0tAEBAbKysrCwsK6urqysrKqqqqioqKampqSkpKKioqCgoJ6e npycnJqampiYmJaWlpSUlJKSkpCQkI6OjoyMjIqKioiIiIaGhoSEhIKCgoCAgH5+fnx8fHp6enh4 eHZ2dnR0dHJycnBwcG5ubmxsbGpqamhoaGZmZmRkZGJiYmBgYF5eXlxcXFpaWlhYWFZWVlRUVFJS UlBQUE5OTv///0xMTP39/UpKSvv7+0hISPn5+ff390RERPX19fPz80BAQPHx8e/v7zw8PO3t7To6 Ouvr6zg4OOnp6TY2Nufn5+Xl5ePj4zAwMOHh4S4uLt/f3ywsLN3d3SoqKtvb2ygoKNnZ2SYmJtfX 1yQkJNXV1SIiItPT0yAgINHR0R4eHs/PzxwcHM3NzRoaGsvLy8nJyRYWFsfHxxQUFMXFxcPDwxAQ EMHBwQ4ODr+/vwwMDL29vQoKCru7u7m5uQYGBre3twQEBLW1tQICArOzswABAgAA/wAA8AAA4AAD 0AAD/AAFAAAAmAABBwAAPgAAGAAAAABkTABATAAGAgAAMAAC6AAgACwAAAAAyACMAEAI/wBTCRxI sKBBgwQaTWDEsKHDhxAjSpxIsaLFixgzatxYEUOVgyAJBhE4K1UrGzZ8EDSipc24lzBjypxJs6bN mzhz6tx5s000XSGDCh1K0FErokgJSpGQtKnTp1CjSp3q1CjSNb5SwcGRispHgXQgeBlYJAyAs2jT ql3Ltq3bt3Djyp1Lt+5abbWI0jholeiFEHs0cAKWqsSTROdSZdoisF0GNHYjS55MWfIyCIYya968 uRAlC1RD9h365ACZVGcQGEgykMuBr6mKVKtMey67MqFz694tcDRvZEx5Cx9OvDhS30KXWONhw1Yq WEUG1tIxUFe1OrUrUzLOvXtS5Ad5vf84cOaXpm7GUpRcc0Tcml5rUu2xpCY7XRaisHnfz18oeILE 3PFLKmkMcA5XqSBhTCpLFEHFc6elootZ9qmFDjP9Zaihf0cNt9SGIIboHXLkEJKNLNukMkQ3AmWx hEDAXFEFM8ogk00qwoAjkBHNoPHNj0AGKeSQ36ihiohIJtlbhwPZsAgoHAjDgiSRdPJKGYTowAMZ NzzRCiet0ICLCRGkcsAl9VWo5pq0MeHII3DGKeecj3AACpPG+ZZHI+DoEMEFiWQ1EA4IMJKFLjoa Q8YqfVxwhkBlsSnppG99AYuSQ/0XGnCYdurpd3h+KuqopJZq6qmoEvdJEBz0QUgEg5z/UQUIqzxS QAtctLPFBsgIJIkdqRhjiQWJbEGAOYRUwFgRHAi0SR4gpOKBHJbQYAsKluBAwiwYqIAMBYIYAAke exC0xhqLBKBAqlJ9yO67GmoaVAq2jDDDIMYkogkGo3RYRBeUBiwwXdoYgaS8BIVgjSGx+DAKG5aQ AEYqfUhyzibOpTLLNAN37LGk0yAoVBO8GISwVMgcAu/K/J0clRSK8CDLzDTXbPPNOOes88489+zz zzj78EqnLjO4iTQQMHJCEDqI8sMSZ4AADQh5CFQLxx9Lpo5+SF3wA8tTFZ2KBhD4QoEAHvjgB2gq doBAXhpjnbVakoAkBtxg9ye2U1JQ/9DKKzgELjgOrxQ+OOCDJ6544oXnfereTUmhsuOU7yYvGRsA EwkFJ6SizAm8UDHIAlFEM8AJOFjih0A/yL1mOFEMxMsElZfq2x2WrJGJGy5088AGAlnAJwqBTGOE LV0ccAweUWACKcC00TKQNwvWDi/kSRmTARK/dO/99+CHL/745Jdv/vnop/8LMF+Tij1SyEBg/fxR jXZGJ3lo4kcmqUhzSRCKwAMPGkCJQJDgHMCDQyIMoLoUYOhqc4vgZJpxKVS9byg64EIFZOGDDnrw gyAMISx0EMISmlBoHDyhCn0gi1escIUtfKEKX8EDGZ7wFSm0IQh/oIFQ5YYLBYADHP+iogBxTEAY iHCKGC5AAUCQgRDVS0oINkAHBgBnJEmxASQogYdD/IIRTvlDNw5BjET4QQwL6BVRcPEIgTAjEAyo QiKAQpQqGIJbjqCDA7bgCPqJoRAPKEQ6kNI+gbyBAguQBUF8kQVqDEEgv4CABNQYEnDY4CDIkMJA pDC0IOyFfgcRhiFAScrj+DA3yChTKVcpmlMKRRQpeMIJYJEIHIBgBRhKBQ+QMRsJ+nJNBTuYK6nC CyccYwrHSKYyl8nMZjrzmdCMpjSnSc1qQjMZuXikiC44FGJYAhxsCKc4x0nOcprznOhMpzrXyc52 uvOd5EyRVIpGhRYwwg6jSEAq/vD/BwF84ApoJMWCnCEAbfzyoAhNyxjkkAZwOPShEAXHGTjwqIJw UyjxY6VGTTZMgigDEzToATnIoAJDACED0JhFIWhhiTRAikIJjSldbkG0jhIkCYtIhTf6IBAFVDAV fniRQGzxBZkaVS7SS4oOnFGciwYFGaPcqFRTUbQmvEAB3uDFJ8DgjBMchQwtMEA3VIKEbMD0qGlR BwGIYYy2uvWtb/2ASqY6EKeGxBe3uIEr9srXvvr1r4ANrGAHy1dWwIauVbFpVJqAggQo4LF/eKwC +BnZyVbWspLlJ2Q1a9nKUnazjw0ENRDbVMUKxBtPqAILBtEJcnACDxKQnyLkIBCo/51VgifwShV2 u1tleOAJpJ2naZ8C1eCusmhIMMBpxKAaoeoCN6jBhUB0cY2sEcAGqzAud1xWBBNYIxCOIMGAXsAL KexhESUQAQboIBBcVPdjA7BFIbU7HLuCJKP0pZ+8wOECcZRBGZ8wAhg2IZA91MAADyCAJlrgAIFU oR1jmNQ4DJCNbZChAG3M73aH65RfsIITnQixiEdM4hKbOMQoyITBNNwyDjcFCcGAQjFmTOMa2/jG xTiGJ1icJN8kIRt9CEUeblCBGBwgEI1gRCgssAY5YOICFqjEAjpADhI0SxZU6GVlhGALWwQBAvLk sd5cnBQpqFLMjgMPIDDhAV80Qv8TI/gDQXRAHi6M4AUiyAJz5yobtPoZACp4ChL2gxxYhKADJGiH JZyDCVlIIwE0GAQlMJEFG1yCBlXgRCQaHJvb/jmhLHhKdEZEZvgVAs2UGw0ZWECBc1ChFOQwRAZS YQdm0GAFArEBGWbwB01ogMCokUQ2BMGNTyOUgqmy70GAEYpDIEIC0I62tKdN7Wpb+9rYzra2t31t RMg52aUmirtQDTZlF4QGV1jEKtbN7na7+92rcEMg4E1veEfCFvXO97pnMYlW6DvfTcjAv/OtCGkM vN4e+MXB4d2KSIR7KHAYQHadQoM3XPcKgJDuU7IAiwLExynEWEATZJEAazyFC3//+IERAkFJpFAh CLgABDNsUABxJAUWWUgFMhjwCx74YWJIscWDuuKDbfRBkbqZhQUgMWin6OASkfiFHioR5qTQAA/K iMQEqNOUdlSCDVmgxAKekoBJcCFqA3DKGqhABhDsQRgbmMBPhQILAwCVE2y4ggcY8MmhIKEdAiEH MhwwCWmQ+/Cs5AQsxAEJD8CBD6PwBgYW4QIvAEIRk/CGKwQhkBQQQyCZnAQFINCNQSQi56nQRAS4 QAVf9FEQ3tiEBkYADC5I4BAN4AMNMkCODjxiDwLQg0AiIABHpAO4iDdOEmzwg73Q2RkfUEYqknAp G2BRIMKoICxYcxAjDCgVq+D+/1B8gQMfrIIGBDjKxE2y0SocIBNkOEM35k//bpxB/vWvP/7zz3/6 41/++/d/+2d/AziA8/d//FeACniA/md/DNh/EGiA+ieBCah/EWiA4rAB6/cbwZF872JuBTFuHghu xBEFkCAFyJCCKriCLNiCLviCMBiDMjiDNFiDMvh5wvQUNXBdIgBUvrAApUAQfWZsRAgA3FAy21Rq mOAHF2AJYKAHzBAKIaBKBVAJ31CERBhMSfgUE9AKW3AJe4ADinAUieBc74WFf4YGSBgiIKgUFKAD sBCHcjiHdFiHdniHeJiHeriHfNiHecgDXLeFw1FcI8guRSMOOtAELMIGDRABh/9wAKlAA3dQCJRk HWh4iZLRBXjzFEVDAIaAAZmAB5ZgJutydSqAAGWQXeBgCGaAia5IF2bQAAfQB7RYi7Z4AHtgAhVV FMO1CwxQBFpwBakQCFnyA3nQAWkACl8RBK7zis7IFtMwdyFBB2LAUcTRBCkQCIKwjdzYjd74jeAY juI4juRYjuZ4juiYjt3YAAbQd5z4cBjVgYX4OKYFC0CBBP5WBV4ADWBQBDhADVtgDULlC0LACjfA CgiZkAq5kAzZkA75kBAZkRI5kRTJkDnQLJhSNKvQCWRACg8AAcBCAoF4CdJnNc34jBG0Ay+2OsQh NgGABbgwCTkgECjgC9sQOyb/YHgJQgaehpJZkwvGIAVCOZRESZTGAAc51ZLwGBS8EAzDAAVQGZVS OZVUWZVWeZVYmZVauZVcWZXF0Ak1RRwpM48kOBxP8E1sIA5quZZrmZZtyZZuqZZxyZZySZdveZd1 KQ5ssAY8UIhF8wsqYAAkQA4sIAh/4AlHAQYnYAApoEkqAj3GNgcRQhTOsIFTVTSvgA19gAIIIAoi cAKZAAaWwAzdIAgt4A2pMAAccIVEOAeZMAGKEJuyOZuyuQifMDSkJTbYkAEMwAPtcCl50CFyAAlV 81JYuIukYVxtOBCcQpb0KJby45ymIja8oAEiIAfCcAIhMAmsYQMX8Amd0ADT/9WTWRMC0tlKSLEN nyACd7ANM/AAoWAHTfAiFDBEqXAHGgAZB9UDhkBth/AC3zePYuMGnnABlXAHipAKBMBpqYAIiTFU kOlLHgASA7BiArqUIfEEImAOb9ChHvqhIBqiIjqiJJoOUXSeFoWhICGCKOopyykQSOAEODajNFqj NnYMbtCiROEyuIACe4AJ6cAJEXAAoKBI5vAMtRAEXUAOkHKSASMHAXAjOoqeQtEK2OAHnHkCJVAC KSCah3AJEoAImmAOqSALyqBlHbMHgYCcU5qiRIENGlAIP0AHebEH1GEj3VBhjkmQNVCRftqQNwBd bQoSL5oKLDqogigcjOVYkv/VqI76qJDaqIBwAHOFqDs6TM7QCQugAtkwAwtwARh5AEqAAxKgByNQ C5fAkrUQoWoSDlHEAzpiqYQ6TLLgBo6wAm8QC5agCohhAYQQCIogAgFAClAiEOaACK0oKeXACJH1 B4vQR7LKFx3FB5KwAEPAB6nwAywpBizSANJQAGLyANk1IZMSB0wlEKugTdHqpoMYVesKIoUqBYnQ CotTr/Vqme9qSgXxBg5wBYTiAAgwV87wAA4gDb7AXqmwDlGwDjTwA1KqC0VFG0SQr+9IEG4QCn5w BtDAAmDwqQJBAYbABSjAALcgB2wABH2gCZQADhO6Bx+QJpXxDI2QZDBgchT/yyEEcQ6XsAaboAA9 6A2T4AO1cAG0lQp4UAEgcAmH4AAkkAqhAArthaaTIQQDkQ3CcLM4OxwmiAxU0LVe+7VgG7ZeIX5Y mykqikmTU7aEdkp9ZwPuWBCXdEkFYQRWwA12e7d4m7d6u7d827d++7eAG7iCa7do0IPuEyrGgApI IAd24AlN4DC48ArRsQAOEAJeUAQrMATCkiypYAPAILU+GTCgQDiFU7qme7qvoAOP0JfdgRy6cAc8 IAif2Q7rcAJrEAqxsADgIAsV0Ac00Ak20LXQsGM0kASsGrqUkgIosbzM27zL2wqNwLobdhBZwBqj ZjCrwLpVsGIaZwSw8Quq/0ACmjC+5Fu+5nu+6Ju+6ru+7Nu+7vu+mmACdne4xHGoaltaxLEEptAB k8C/k9C//tu//zvA/+u/BizAAUzAAFzAHZDA/NvACazAByzBBazABAzBAjzAGCzAlDABb0u/AlEA l7AFlJAOLuAMecA/n3QBiFAGmHAHwHMOFXAIipANJoCaG4O8k4JsFsQkUbAFbvAJgRADCsAJhwAH MsAJa5ACQ+MNAaACa9AIj2AC1PEGGZAFe2BQOswmPPycAwENe3AFNsAYPDBaSDBXaSAAP8ADD6IL sZMNenC1nbbFbNIF0judZ2sQ+HW/rZvHISiPfIy/w2EMgBzI9eXHA+EHJ/+QAxoQCY78yJAcyZG8 ASPACZAgyZicySvQAZncyZDcASzAAZ48ypQAChswyp28ASlgCajsySxACa2cyR6AAsVRC0AXFUmQ S1GxKFNRdU8BC9UoFdSQMVFRBrhZzIaMeMwAKLH6YoMAAQNgAQfgrklxAJpAAL9DGE2BAYIwAI61 AZVKFLIQCQawAIVgABmGFLLwCWLwAAmQAQJACBkgx0MhAE27AEf7B4AQCdcnFIbQCKlQBaUgDo8Q CGkbGtSwAHkwSE9RBg+gulmQoE0xACCACoVADhNwokQRCcigCITgBYzQz0MhC5CwDoMwAVWgAU4B CGmQCNLQCH9ADhDQckH/8QN1gwuMwAuDgA0YQEdDARxNMAkz4ACH0A3prBsfjBQ0gJsiAxX4ihQI 8nAd0tRO0SFPTRQ4kF0YKrfJ3NVeTT9QwwrrIAVRsCA4UAT4dgWeFNBAYQlcMwCV4AwIMKFDIIxp UAiLwBipsAlnAAag8AOKBAutwANLsGIOOwSXpBLAIH18ML94oAGI8AMBkNQU2wm2wAwCAAkTQAhw oAzN8gAFwGsiMAiLEDupEGACEQSNUAJ+MAp2IAinZzV5QAkjoAzRIgHpoAkKmgAQ4A0fYA2VcAaI kAQEMAGSEHwCMQQNcAbtYAAXoK5luwGyQAiQoAEegAD6YQgacAplkAAaUzAJwOCIAuELItAIIcAF v/ABGvAHQKQAauQAH+AIjcAqj8DOiZBdkBAIqXABr7AGnYMAk2ABlyAA6/AAXIELb4ADieABJfnV qbAAWMBTmMLVpxIQADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/content/vol103/issue20/images/small/zpq0190621720004.gif R0lGODdhcwDIAOcAANfU07GxseXk5NTS0KqqtOPi4tqztdPOz6mpqd3c3KNqVH9DNMLByHFAMJRn T5+fn4xMOtPS0vPy+ODg4urc2MfH0JWVlf79/HZ4kVQ2J6R9Zfz5+s6wovb19IZIN728vO3u9YNE NLW1vkAnHZZTQOzp6uvp6bW0tK+vuOjn5ufl5Xg2KeDh3vHx8pdXRN7d3HhJNtjX1lQxI8vL3Vg8 NPXw78zLyno+Mfn29vj29UtIafXy8syqlVUmHdmhw3IwKXlEM7KyupGOk/v6++ro5/f295FKOvb2 9qyKcvX09bq6xeLg38nK1+He3vbj7IxVQtjW1Xo7LZSWsA4MPUYpHoBHNppTP7q2tNnY2f31+Y1O PG88L9GrmZ9fR45EPfLy+J5bRvDw9nI1KLWYhP77/fz7+8Khivr5+dDR3ejl5HU7LtLS1aReRfb1 9cDAwPTz8+zU3plXRPDv7+7t7e3r7Ozr6+rr6enp6HU/Mejn5+Tj4+Lh4d/f3vro8pZbRIBENenp 67d/gsSMnPX1+tTT0/fy8tDPz93d35tWQog/NrdseOHCwpZQPaZVWmZGMjQdGM7N0JtaRfDu7smZ nfz8/evq6XRmcZFOO/j4+efm5dfU0ubk5NTQz+Pi4a2trIxINuLg4ODe3pZUQ9za2tva2drY2NnY 1+fm6NbU1NXU04ZPPcaroJubms7MzG9NOp6ftJJWQtra2/33+vj19e3g3XhSPPHv7v////39/ezr 6WotIZhLQfv7++vp6DwfGI56b4eIk4ZMOWg8LPPz8yoZGuHf3mU2Ke/v731bUe3t7d3b2tvZ2H5A McXEyZJRPopSQOfn59XT0nA5LY8xT0kuIcjIz5FTQN/W1TAqR/T1+r6+xdHR0e7d3YBMOfTy8Kam qv7+/YI7MXlAMvv6+vj49+Pj6ff29trM0/X09JtcRvLy8fHw8Lm5uaOkquvq6urq6eno6AAA4AAD 0AAD/AAFAAAAmAABBwAAPgAAGAAAAABkTABATAAGAgAAMAAC6AAgACwAAAAAcwDIAEAI/wBv4fp2 q+AtUwECxKCU7J3DhxAjSpxIseJDE+sMatzIsaPHjyANFvCE4NYeVsCarftwJ0+Kl3lcpogJk+ZM mjZvMgiyZmZNmTlj5tlUrKjRo0iTKj0KYAChpgMAQEmVChWhaNEARHihrIPGcQkp3aJEDhc5UyHT cnylEQ2GL2rjyp2rERwOg7hs8HLTRqM5KHQNfki2ERBbjkyYBF7MWOOGuwbBudm20RwqxkykzDCI RglIKbgai577WCMuNwFCG/w7+paUKRhCopky5VDr2x7LQC5IzkK7gobctFJnow2648iTK1/OvLlz chOAHbpgrrr16+TKYdARi9z17+DDi/+vbmt3wTMGIT1oluJEAlLw48ufT7++/fv1RymLX2zJfvuh oCDFGjEsZaBSXWlURzNubEROKbhFKOFGlEihmQgY0FZBOa9gIAU45NA1BzQdkWPDOB2po45HdaDH kTp7gMPRHWfsEeJG0Bxhw40GobMOOHdwlMkt8KimUSZF8OFiQZTYoA4fMk640QnseCKEJ57w8cAx qJ0QwAMPBJCAOg/EggAwCAjRDgIk3RIAO4aw8oAFQiDwzQmegAlmng+cgMADL0zoCTBCCHALODUk quiiNVBwzaOQRirpNRRU6miilmaq6aYUcNMpLaCCqiktF2wqKqemVnpqprmERAEEEAT/44GsHsxa BTN4qCFGFCv00IMuK4QTTgg33ADEH38UW+wKq3CgyhPQPiPtMy5EAgYYcTijhShdWKOFFs5AgIgC CrDBBhhWxNFFJBrQ0oUWn1xy7bWIkHCJByGEwMwCf1QRzB8hQBBCMKKkE4kzLoRrTQhIhHQNHuKI gwceDWwhjDHS6LpCFFH0QMzHvoghbCIhLFDFyVX8sQCzHGjxhCrdwCDzxAN7sADFzDhDQiRVSANE DzfsjEgcJDDCiDMKUODKxTKM8MjHUEM9AgxdkFuuuVhHQrQzl0AQTiAONyDM2GNnQM0IaPsyAhVU rE3N29RkIHcGjjhSSy0bhxAOB6sA/9FNN7XAEDMMDcjwyNOHr604FTLI7QgEu+xiBSIOKDBGDVzw wMXmPHTuuedmhD4GEkhooIEDDkBrjSiTIxJJLWPg1korAkQg5S0IoGKJoVLy0kwL7aBzO25iBRbl 8KPZIERI4yzDUTPNsENIDC80AwpqNgggQALNIB8SKCwswQILenSyhPmhLKFHE1xtolYZOYBkwx4f tMLOOmfYIIEPgmwHwhfZgIMgBKGDV0jgC1/g33bKgcAwDFAHGDjgF84hCCFgQwkSVKAOGIhACcwA G1KQ4BckAAwdoEGEgICgCCWAAmwwQYRfUCECR1iBC2ZjhhKQwgY3wouTNOgWdQDGN/8CcKIPgGIJ SEyiEpfIxCY6MYnKUEQjGiGIJ1rxilh0ojJ28CJPBKog6DhDHW5Rhi967yOLyMIZ4xI/jczhA0Kg DEeat0aQZAEOdQQJ/OZCxzyChAx49KNG9iiXPgrSI30I5CEJGRc/gWIjASiJRuDxi1BsxBOUYIcJ DOIGNwjBBhqxQZhAKRA3NAMYY2TSBwIAjCJo5BsFOEEqgfgAVrDDIKFAEwJUYJAAfAMBtywIHYRw AmAkoSOEaMUtjMgR1hxSkADYCDjOQAlenGFFBalDCi5gnlvIIUh+uYyEOnOLVyjmmaIpjUGSYEu8 gAgti8kELziiBDQUhgDoXIxdNIL/jm/8hhDsEIIb4OEJAFzloFfBykGxotCsAMMTCc2KFKqxDFNY 9KLKAIY2UhGBjnr0oyANqUhHStKSftQQwjNICwg1lgKYIhnmIIQsfAAHWcjCCYIohE3P4QObymIR PbWpDxYhCymcwgfA2MBNBdEHm8IhqOWwRFB9SlWf9oGpTvVBFmwKVJ/S1KZZ+OpSdSqLp271p1P1 wTnAStNxmIcX7GiFkW7hzEMq4TD59Ig6C4KLAJygeAWpa141giEMVKAggCgHCjyjkddgYxAS2ust ztCnyohzsBIaBDamoAMlAOKu5YiLZDtiFghh9rQa4RFqV8va1uLGDRZ4wBgp8Ixg/6CsCgvg176Y USw14AEIE4MBEIRLsS1soWJq8K0aOMABIzjDGtB9AixcYLAuuEAUWhPFddWltXU5Q13vMtglFEAL P8DiCbWKlyhgoQqbheBbCANXF+plLzB0oQuMsMZ9GfE1V+WrZMzgrTTE8IMVJMIIIfAYMQ4XMnTt 4hMeQBYQxOFbMaxiFd14BrSkCwtRIAIM50IEImABgedawxld+MQKSMAGqx3sW+TtggeYsYIfhCNe nwhHFELggvteFwILCHDAupbjKOhYDLrowS9chdsqaBgWfvBDOrrgB1XoqsAcW8HGwsEMiwmjAf4K RslYVgWYqQJmfyPcFjz2CF/4Qv8XIaiCMYwhAxlQgxkHNoKen1CLdtXNFa64m6AF7Yq6OeJiGahz nasQCaM5GhFdaMCSQXINGvw50MjI9KBrAeg/cxrTqKucAn6gC1JzwAw9aNsjRpABYdDNEcgItQNM R+taa0ABiNiFuTSAhMtlTnOb+/Xnhs0D0ZHOdApwgB+MgDUO5FEyzRgGR/ZwBHe4YZ4GicU8IeFG EhkkBuw4BoWaQRjXmvvcX3EeR9wATtdeIAIzGAM70JAnP7HjAyeAB76xoIz3tTEuhqzjHV3LyB7F oAUdCbgga4raghdkGyc4QsLVjU5AntbhHAFHLA7RjCNQot+DJQMg+5BPcPzbI+j/8IQbEGCKcbih EiaIucxnTvOa2/zmODcBPIoBikVcI4v9QWLQs2hFZXhDLahAgDs20IphOH0YKhrGG6ZO9apb/epY zzrWz6GIRWj962C3+jDksA51UF0SKa0jO7yUB3gkoQVjzIQnisAKNyQDHgIYxgkMEYo6CGAdd0gC NARwhHvD4w6QuANCIvCBFyTjGwJQAR/QkQx36CEG8JgQMFhakDvsQQ/qOAu6ZUcEbiwiDSUohSHY UYBQuCEWbWjDC1Jgco0IwBPswCZvTDv65GEIhEpoBitY8Q3YNiMArLDBHG5hHk84SeKrAYyEdDAF YPT+I5J1QztuCYoAQFQSVwjF/wvGT/7yvyAB5Uf/+NVf/iVIoRl60EMsNhuENHTi/vjPfycEAI/+ +///ABiAAjiABPh/BeAVBuEOD/ANc2UO0RQYQvANFmBGBaFYG1FP12cQknUGCYELyeAG30AIbdAK 5nAEJniCKJiCJ2gOV1AAKWgOUtAC5DCDNCgFgKCCKugcOriDPMgcc3Byt5AJuhdYl0UXV5AHG5EY HfEFeNV7oyUAx+QXMbAYSjAF2JANBjEITbgR5HR9uqERy3ACDaIOCbANd0AOgLEIJHcLWbAIZFAQ TnAOBgEHclgQr3AOBBBa5yAFodWGsgCHdagEBFCHdkRUBdEHizCHinQOTlAQZP+ghgVRCG54iIlY EHRoEOfADY6ohl8oGN8QTNE3GhVyCCKQFq8AWOcmWQiAAZ5QECdATHuAAANgCLRYi7Z4i7hoCJxw VyIAAL74i8AIAAUSAxayDMF4jMiYjMq4jMt4AGl3C+RQWeGUV2ggBWHAWpKVB29SEOOADkUgeqc1 BOYEEkqAAR4yAcPDTRoRA0IQAA4CT6ylQ69QDmhAfefEEYewhaOhjgZBWZ5wPHQlfRkIEhmiAzOA CUMgAagoF5JFDqzQiibxAB9QAh8ADyqQCSpwkRmpkRvZkR6JkR2JkZkAkh5ZkiZpkiR5kiE5B7aQ C7mQB9RnCVKAAjqgA4dgC3P/4A3eAHMxVwmdMAuR0Qz9Z1kDeTuUUDzlKAWd6BGx8AFFoALrEJUx F5XrkAd1QJUCQHZRqQdUOQebQJXucAdUeQeVQJWbIAlYSZV1kAlgCQ9UmQd0QJUqMAdUyZVR6Q55 MJZlGZVzSZWZgJZR+XdRSQdsGZV1oFpq4UuIeQtFcAJDCEbAAIrraAE/tBFuAAyPeQsn8AGe8AEc 4QmZwA7lZhBYwJnLc0kfwAq2c0mEAAzweAsu5yfd4z3RQwgcMQyEgAsnQHF5oXyRoRHQkxHLBw/b 4A6Q4A634AYACUZLUpTO+ZzQWRCWgAGWUBIU8CyzRjpjsJ1jgAzGMDa/NWG5/6IG0mBcZHNcuSIG FsYBn6AtzrBeq+MCLkAC8lkt2KI1cfBh9hUJO3MJKBYJotAuVaYKWjCfRvAJ7ZkOBqOgLhAHRuMM kXBfiGAFVUMC+uUHlxAODQMSFKAFEPAtHlorIhoCKiMxeLACamCivjUxFAMxf+ABN8Bcl+ACG6Y6 oiAKcYCfsKAFq5MOJNAFzpAI6mIuYBChCtAF7ZI6BEoC10IC+GIN6SBlVFagcSAwsHBiEICgIeAM fsA1GuoqEDArEbYANxAFxcIM4VBjPeALUNMDK2AEjJAI4cAvyZIxavADF1YFf/MsTyClWGNfzuAB nwALsMAMIdAFbHAJRhChE/9KXenQLsEQBRBwLVZwoHKaZSugnuqpKx7Ao1xDAh76CcygnrqwoR9x DcklDgsgMRUjDVgmLAoGMsESDokAYSYDAycTAlHAXBr2BNKiClUALvlpBdpiDYTqB1rQBSHgAWDA CJfACFbgn9oFCxpAAcLVDWemCkDQAMbgK7oQBXr2rNBqBY52oJ+gL0HGDLxiqh5xDcb1rsY1ZzLg rbuyAkn2KxwzLHggDXjAWxwjDha2CjdwMkCgp2kGBMEQDFQAMj0QBZcQDN0Anp8ArY5GnxpwDU7j C22mNm3jZorjZiCrsY9ABeLqaIygZ58QO5RGNmMzZy7rsnMjDBaTaIzzNnT/A2hqYKh7swoG+zcx M1wy0wAFWwUNQA2HkzhxgwefoGdw6gcOgAS2MAahM7VUK7VmMDq0lmyF9p3P4AxLuwskYAUeMAKT 9hGcMAJqgzZsQwVwQw2NMzdyQwOtJgyOUGiBVgs/YGM72wAyIzOOkAFtwzaNY2h1+2m1IGuMoGts oJ2Y8znCRmxVe2ymgzrWwGy75my3MQ4XUAmLmYFnYALkQAfRObpnhAsP4AYPAAwB8AH3pgeoiydX 8gDgQAhuICdCVEsLeALfkJrkgA6r+wHAYAG/1A7twAoIYAikm7xzwQcWEAALuRrFgA47ML3T2wHm kAM5MAvYi73au70dQL3g/xu+4ju+5Fu+5nu+51sDqOgJlgAM4jZxzxML20AIsPQC0IAFoDAMSZAE yTCbh0QJy9AHNDULAUAIWOAGqKAH+JZKvKdHQLgRH2AKXhIABXALgdIHjWgQrFAATqBGGoHBb6gR TrCGBkEGHbwRGNwaZmFNZ1AGZXAEZTAOMizD3hEXQ9BNzENxdQQHHsxatbcRBfABfAC/C0dwQKkR kiAEfIBNuCAA5KAHZARyhzRwqPXDYCgEkmkQCudHKXxxR9wj28AOX7QNFqC6zUAJL3cHd3B4a7zG /+fGatx/atzGcSzHctzGbHx48GAHcKAIglAJdRDIgjzIhFzIhnzIiBzIm//ARRtxB6xwAkScTzyM WRj3mXgSC2XQDHVQCZzcyZ78yaAcyqIsynXAdYqgCD6wyaO8yqzcymnwjGmxxejUxc9Uyal1AgUA CeRQBlKMWYp0SFasFrKMTiOMTrbsEcP8TBZXyw/cEfrWuYPVByHce5QwS6nFEe+wnHRJCNh2C+pQ BHPAI0VACOgwS+hACDKsEccQA8MwmreQBO5wDKhgJJlwBOgwhOQAzhuBHs15BkVgzYIUPTbwiRV5 Ai1gCLTrBlXiBgWgmwB1unii0A0CPQCluyoHPQrNDhrdSZ7AICdAgbfRCjQwhQWBCkIADG4gCQEw Oyzd0i790jAd0zLd0jb/EAPekCjrwCg6jdOKktM9vSjrwAk2YAOGMNStcACcMDtJPdQ2kAKSgB53 YAkPYAlv0ExFqLweYQM+4AOovAiwdQJY8A2skEqVsE043EwCidUeEQ1DUI0gMAT3iwV5AAoxgA5J gAWtUAn82HkA9QYC4CcxMAfhZ36EXdiGPX6doAfFcNiFnQCdMAeQHdmSPdmUXdmRXQfsAAWQoASo EANucAIMwg7QwyAfEA1E8MXL9A2xwI3owAvgGCHUJwWju08GoQeeIEt+8YARUo1KwFjPKVkDgQBz 9dq4UQGbUU4b8rzottdB2Jm3UACsYAE2MAxuUAfucN3Ynd3avd3bXQdS/zABkiAJ8EB9SiAJlg3Z kqBNL3ET693e7v3eMAHf8r3eQBG9GnEED0BKq3HVcXEEuOnOtxAGW0gA1ziQkjUHYVIZaR0XlIAA H7AN3VwQM8AAGzEDvn19kgUOCV6an1QJspiLIF6LEWABH3AAtsgJUqANMQAFLA4FhoABrRDihtAK ABAKNn7jOJ7jOr7jPN7jOL4Mz4gKWIC8frHgcuEGy6cRlKCPt4AC6JiBS3kLhkCZCs4YdrcRh3Dh BmGBGdiQCOC8vDAHmRBGDTwXNPAAGyECT74Wc4VutF0QBNU9SRAcfPAGNoAOYWd16KAENQkIVKcO Mcgc5qAEDPAGT3foiP+e6Iq+6Ize6IpOBycXjQ+AIvu9GNqhA5BVgSjwESDA5K4lWQ3umdNIhTMg 2wXBAMftEa8AF05oHgWwjTFQxm6QAp7gA9MgCFstCLe+1VK01Vw9Db4+DX6MAbYuVfyz67+e69PQ CL7e7M6u67h+7L5+ysGOysce7dCu7NPO7FvdCNZu64KgCc84DrrbgEZOF0ygBEseEuve6hqRBH1C 6YF17nShBFJwWCBRDhAECKMnWSewfQXBeNswDCQ4HgZvHUVQkDS48At/CNuhBGXA8BI/8RRf8RZ/ 8d5wcurg3wWRBMcQeq+ZRyJQiubG3ODwJwApWILEBK+Q6aslWcNATJX/QdL5NAFSAAKrFeVuwgpi gXzsYNtQQAgIJfQNpVARdfRDP/QNJfQIxVAxUA3AQABNsAxUX/VVrwzaQBsoUAxW3/Ve//VgT/UA 8IzC546jjloEoOUGgQIk3+mvIAJqPxqSZQMI4L/z7lrUpwOLRX36WAE1ifMRIlnsMMQFwQfFVwcf kAcjufiM3/iO//iQH/mQHxNEwMnaIAKx8PgpUAlBIAWQvckmwMk9Ofo8CXM8KXOcvAknlwQyn1pl ProYgA2xMRpvLhBeUuVYPQOv0Ns6hA2bHhiSpQ6tL8OuHfJqfVdooPubdRhHCRLMvfOhEQMB0Awl 8PMFcP3Yn/3av/3c/9/93v/94B/+2J8AsdAJsSACtAEMDKANGAAMKkAEvZALlbAECHgoCCCGRKnW geH3OjDyeR/xAHFL4ECCAs1BKZhQ4UKGDR0+hBiR4AYcDWOwU+FJWallhKIt4xgBFchlhkyVQmmS Y4xtJAF85EgoFcltMVCaMuRyAMlUEUgOgEIzBkicJ5f1JBkN5rJtUFAuizA0pVFUPjkeWCdR61au Xb1+TRgAQZGEZwKYUojAhkJ4QuoodCOEXMITHwJ8SOjJxIltBWO42fYtIYJWrNDljQFMAEFKHx54 aqb1TgGFyT4MU3hEnUJwMcgmrBMLXEJQw2IlSRgK2odjBdctdpcwFv+6GLgSJlDnmeCwD9BM2QYb XPhw4sUFBgglBMG3D81O3LIB7AWwBycQuMHi6Zabbw++ufng6YG7AOyyP2DXTgj6EycstHvAqr2n dqwSGMevkFzrYTFQ4TriFl5uSeIMcloowrYk1tGMHF7WGaeFM24hh8EijlinCHTAGeeIAosoghxK WiDHwHHyQzFFFVdksUUXX4QRP0tOYEUwWpAwgwcddzTDDCS2ECbILfDAQw0j1ZBmCyWVxAMIcW5Q gwMOjHBBFBfS8cPKdOK4cst0ugAjHTHjAKMLMM10gYQutDBCAVqeUAUWUURBBJEyxYyEBBfCjASM SOKIxEw/u1AgDmf/0oHlkhACScgSdj4A5hYKVKmiG0sv7UaVbqpYYAFxiCQSCCDwaKDULRogdQtp 1BBjFQ4u4bJKF2aNJB0wuAQU0Ej27KLPLuJgJJJIrFHgVw1o8eOZJ56BhQRntAiBGQ+s0VMUZ5y5 xAhRzOzCCkS6YIMEP8y0IhxGG6LgGVU8CCYYD/7wYIE/qvhjAWYWAJVUUYtccgs1bgCiihukZMQF WJZ95hlrRMm12oVFEXZbEi7ZVgFEPvkykmOfqOIJWKy55JNEpv04GGtgSQfbXT+BwBpr0kHECpZh NmKFcxmiAAIttNDZA59DAHoBKKURQxddVogiihuUFvVTcf6ANwop/xNJ2OMnnrDGBUBvdeFZF7rI 2g8PjGCDDXCLvfPYZ7SQkwRGrLDiEg+iYCZpuqWFwIMQtNDbg0u6ntUPZ6JAwiEK2HWX3nn/YGbp H35QowdfHnlEl3A+UfSGBTwQ2MgoWl2lYz9Gh6V0MsEAAxFRsMxb5xAgKNsKIxAxO51aj4XFhUje LttsM8XEEhYPNFdjgZazTNNlCKQNYQzD8w7BXqGhjCKcRBIJp4dHiOHelxVIAGOXREKAWhwkpdHF VVWuhlMVhWkvO+ZLYMnSA2bSYeOTcBix02w/StcABZghBjFE4RKIyNMnPuEz+4nhXwR0IN0gQAJr QCBaKzBaDzTgkP9reC5palCVMR5nvRD0gBiUe4QvomCETxjBCBDoVBWA0CmpcUBZ6lJFDrVApzJF Qm4QKJ01ALUC+L0tbjrTgpsUsEQwfIIZK1iBGHrQgxV8okxl+xXMLrFFI4SsblEs2gYbco0mOYlI pZKGNKC4gnDoYnvdYyMJbzCvKlRBb1FaxQIylalnbAoCzpiYFlzmslmlYwXWSNrXwAAx4AUQBsIA kjAyQI0RoJAYVBAGLHq3yTpZgREsBFr0VlC4MZ6xAafagjGMIYMe6KKA4ViB9nzRAzGEIxzRc9IN NMcMcYAuBOxLmKacVAVVyOCEtPzjvYzRAzUcEG4To2AAMzA57qH/kHK+wObkHkEFYzTJGNTAAyP4 V6dv9c4MHJRGqZq0ABmKA32tFMMa5cnGAbqzaA68wQpcRUxNXQoGQGiAOIzxxllWsQqnhGQLXdhF EjzhFy+YpAyoMdEMZECiE5WBDKiwUSpQgwoj8AUVtAAGuJU0bmL4hUM0kVEZqFKVLTWGMGBgqQXY khnhYAYzUklRGjgCBvYKwQqktEd/AlQYMWWlK4EgDCpo0xcjuMEnvOCFRBjhCchAAi0coAGuchUJ X0WCBr6qAQc44Am1qIUjVJkBGGBLnEYQpwuMkdIxBsmud62oR0ew1xFwtKMVragjXOEKNTAjBOHg QB67AQMYoJWx/zBoQAZACtIU7vWp1LCoMFq4i11YoaxIqAGPeiTaHplhDGANq1lr4YpaaOETb0ud M2RAV4Zc46iTpCRf+drRjmIWsBXtqWDR+oM4JhYPj3WsI6hR2b12VAa/FW5rjbALMLCBq2MoBBe0 q10ecEFH2/Wujkp72rCS1azipN0SV6HSiVIUsDQIriPkO19HCGO+g2UtMp7wOCgmtgEwcIUwPIrR wLpCuMhAMIK3qgANWMwKbFDAV8dQg/DuqLsWJm2PTttVBZgVfGVTAAcckosxlNjEJ0YteSV84hKX tsONaMQiAuCKBP8CrC2+sKukhGEdnVYRgQhEjgyAg0UYYBFFRv+ykY9sACYfucgGkNKOeaBhsY4h EIsgTisg0YwAoIgdL/DEW/Ljjgdsox3AeREfYnECQ3jZFAhYTH4SEABUtGI0McJznvUMDgREwALt uQgfbmGBD7ADGCdgxzcoAwwbGEIIbkj0AxDADsAEYB2S8IQbThAATn/ADRZgR3n0XBx4zIEcAnCD JEh0BHCsYw4tSAY8soKZY9QBHpIoQADIUYck8AIci2k1OloggGS4ugXDKPVcRr1sZjfb2c+GdrRv 0QJLNIMVa9FPNBICj1iEIhaxWMYLws2HBGABCzEQs7S9Qo4ODAQUlhiHpxcyjmUkJAIBAAYwLOEG DCTAEg+I8y3/WqFnXLTiHILwwTXcwIA62yAPrfiAHtShjgNApAw5KIiy513vghTgAW74dgxEbgr/ oAIV29CDnstACkqAgxIt9/U4KHGLmd8CF+QohcUx7pATTYjeCrEEttV9C0MswQbXMLohDGEDQhgi Ak2Hwgs4AZEL7Hwhj2LHjNxwhiugQRGKkIIUZsCEGShBEYLAgBLGPgNBgB0Da2fC1zEgdrL7oBFo r8AMxv51KbydCX8fe9rHDngUvH3wZAfGK/S+eAZggOyLn0HYDz+DCmCAAWjQO9kLb3WIjEMZA8HE IBIyiCEUJPSjx0RBKDGImgsEDoMQfUFIb/rYE2QQqWdMNtAs/xDYFwQX2Wi9QIbQgjdo5ecwcoIT 1H1x43McRnBY/iwKwgssfMAGPSfEHSIg8xfgeRFwgIPyoc15mrPjBHMQyB3W4wlClMEGcpBE/OU/ f/rX3/73l38JBLF/H+Df//8HwPsjgh0oCHBohuaYkII4vjyDvmdjPoJogQA4gQhQiAXEM27oAwck v1vItchICAuMEVlowGZ7wIHojG8ABYGogwdoBgSIgXFwgwLohBmkwRq0wRvEwRzEwXM4u03wwR8E wiAUwiEkwiL8wSUgwIKQg28QNAppBQGwAXIog88btT4YwWUDhw1EBWDwQAV0Pj27wlErwYFwh2/o iw/8wjxLPv8SJD9yeABDiIWBOANekINb8DxmIwM4kAVZYLYNLIhMwAAhCIBmKAM3IIIUQMREVMRF ZMRGdMRFzAREvAMe/DofuINHxMRM1MQUQMLme7Y1VDk/ZAgQHLUsCEMYGcOHGIece7ZTfJFUTAhw KIxBxIVmqIMSwMVc1MVd5MVe9MVfdIc6kAM5WAQ6GMZjRMZkVMZjlARkbMZlVMZKOIyGOAMsOIJk sEMqdDYnyIJRE8WNgzZQxLMykD6JIMVRE8FQjIi5GIdRiDZXbJGqg4hE2wYYXAYbgIJW4IQBGIAY iAZT4IRlOABlMARlaAWDXAZO8EcA0IRogIKPOIBlOMiBHMj/VjAFoNCEh3TIgDwAPpiEs3uBiQRI jYQCAICCAyCFgyzIilyGATCFaIiBAQAAAFDIgGyFlIyGZnhIgTQF9JOIZDCEOxsIdbgPgkgCSKhD gsCCY2AHjdsDSYAGbBQIcmAHATAEZUOHE3gDU0jAW7AMPYiAARGII2gGPWCHExGIF4iAYwi4WyCE AiAEgliHUJgDyhgILNCDevSKFkw3gUCABygIPRCCuCSIABCAsRiIA/SELhOIYfCE8CAFgTgGwgCG lBMIAbgLC0jKWyiCE2gGT+jKw0QABKi5CAAGT/CErLA5BGCFdtAOgQAFYAgAt9AzSpjGhSgCoaQ5 1VQIStA4UMawDbEcuq04gVgQAgtgBQRohgcABzcAhghgBVaIjw8ghXa4BUOzgEMbTSFYh7pAhej8 BiFgBSE4AfiwACFAzwcwTyFAi+F8CD1IQffUioAAADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/squf.gif R0lGODlhCgAKAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAKAAoAQAMK CLrc/jDKSemICQA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/diams.gif R0lGODlhCgAMANUAAAAAAP////z8/Pr6+vT09O/v7+7u7u3t7eLi4t3d3dXV1dTU1NPT0729vbq6 ure3t7CwsKOjo5ubm5mZmZSUlJKSknp6em9vb2VlZUpKSklJSUJCQjQ0NCoqKikpKSAgIBoaGhcX FxUVFQYGBgQEBP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAAEALAAAAAAKAAwAAAY9wIAw MDgMjwFHhoAMLDqAjeFo4ACukyPmegU1hBQulwQJXMTcSkCgEY8kQ0aIa0E+RAAPohn5JJoBBQpH QQA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/utrif.gif R0lGODlhCAAJAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAIAAkAQAMb eFqkBzDCY2RxJoCrJDSOEDiKAI0KIQmH5gUJADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/content/vol103/issue20/images/small/zpq0190621720005.gif R0lGODdhYwDIAOcAALWav31YkuDX6YNRjpt9rMqz0Ove7dfJ4N7G3V03ebyZv19VfvDq9Yxnna2S utrT5vf+//b8/ryfwuje7d/f7unz++bv+OTr9vz5/XZslPjx+XNmka2cwMGtzZlnnPv//29Wjc+4 1O7h79bG3s+ryt/a6rS0ze/n86WSu/j//8adwfLe7N7J37ycwfDa6oZ9o8KXvZlvovTz+6WFsZBw o8bH287A2aV2p8q41enj8NTO4qWLtNvJ34NeltLK4NSsy7y10fju+M7C3HpQjdi20vz+/7aJtIxf mOHI3vH5/i0dVd7C2+nY6dTD2+vv+OXS5bOvy8jA2evN4dPY562OuLmkx4uEp+HM4dnP4+fH3cS4 1fb2/Oja64d2o6WCsMatzdnA2Y9tob2uzuXW6OTU59GjxFpNerONt/b+//Lh7t7M4fX4/qWIs3lg leDB2eTa6q2YvtW+2MGpy8akxt/S5f3//97Q5OTL4JuZtvz7/ruhxcKewpuNtuTe7fD0/ExBb9TA 2rqSur6LtLynyeTP48Kixfr//77A2NHT5KWOudnM4vD8/+Ti8K2ixLWdwnJHh+TC2e3U5YRvn6WY vGpejOHP415CfdS30/f//66qyMq20+rh7/b5/ptzpa2EsOv2/e3Y6NnD25uIstHG3fHx+cqpydrY 6bSSupFlm7epyufO4v7+/72kxv38/pJ+qerl8pp3p9C10pB4p4lZk+za6sqtzLSWvd/V5/v+//Dk 8dWy0LKFsff0+8Oy0q19rNm+125AgsWpyo+KrLyqy8mixM671t210fj+/7Sgw9Cwzu35/svO4Pjr 9fDs962UvM292P////X+/7Skxm9Oie/d7Pv1+6BvopmTsjwyZMOxzqShwN291+nV5vXr9Xx2nKV7 quvq9fLl8pt6qsi71oNjmayJtMS10sqwzryWvc3H3tjf7KV/rZyArtm71lYqcIRpnfn//+Xm8vLv +JuEsMGmyPXm8cC71NCz0JB0pdrF3enS5dO71urn8/P///L9/t/m8iwAAAAAYwDIAEAI/wDVfFMz TcsNVtDqZbkij0AAGAMaQTtjD5oEI1RQQBqwB9qcTqKGvCmzC9a2Y+V8ITtjxAM1fp1UiLjzQwS+ e3MCbQMFA0YZCSeIuAFTINAlMIXGtPAAzJ27AQZqBLrnKkGCHrsSPIAWrUS6I5ew2DpxAokxFWW+ EYCG49u1MzN+lXtEwEsxLcJmeJk3rQ8bGg3iQWNDzBgJEnRGWKNx5hsVHSq8sKFyh4sjEkaM3FBR SgQLdLlkdGAz75vVR14KxSpHb88NdAg8ePjWKQoYXwkaiMmGqlODLfN6VBPwaIiHcdIGmLOTR4il WR7mDILlaQK4PjSOjBP1LRQ7R1Rqpf+ZLiJCgCZ7ToXYZYRVIQ3cFPwSN7bUmV2e3DS7savKl0ez 7AMGEqsEEoMnc4SRAAkwfNMACdOgosoYoewBAwGyWdLIDT/8QAIv0IQoAw/TBMNAGOJgIAMNjwwA TClvQHOFCkQAME4YRxwBDj/QlABIMpeoUQAWpShQhyFC/HLGNqWg44sRbsBwiT6eICBGIEtUYkcp 9ASyxxmlWGMEElJIkcUlmgyDAyyJdBCIB0TwUsUQvvBAA52oDHBGJx7cYEQM1jgQzzRHxBFDL6uM IkcI96gRyjkzjJOOAxwMg8oRnXhCRiE3XGJMGTDsw8gWl4wBjSY3rJNPE9tQw0AyCsz/woAdqBCB yh5yHBFIFkiwco4nYCzRwx8LlBKICllsAwkJuwyAnxFHSHCJLUcUkoUK7STzSJ6PyJEICrE40AI6 j/gyRAI3iDLOHmHwIcAZntATQyFyIKOAALc0I0MBLSTgCjRetDBMGttgAE0BtnAgAQ+AxBFANjqs QwwCRkCKhDSOZNGJA1fQkoyTkFzyQy3fKCCOBCQQcawtnnhiDDHlzLHON+QcEcYrWgzgSykgHPFF OWkQA4wv3Fwizj5DpDLNLZqko4k4YXiyCzDzQMPLOkfICg0c09CxBTQ6IDOENH0gUQgbgcwiBDTG SJGDJ2PsoUIsAvRAjBvnkNBOOKE8/8OFMe0Y8YMKhbRDBB21lHLDGXsYIcgcCigQiNBDPJOAO9PM 4Ewnb0wDRLzWqDBvOe7MokInAcBiBA1AaNLODzCcwIAms9iCBTkgDJLJNA008E4bUTxygzMgoMAI Pl7EAIITTZSzRwnQsNMALLPoAoAN+6yjSS4iqEBMAd9csUMpLZhzihsqeJIFJD+MEsY665wTRict 9JBjIAXIgsole4QcSG06gMYb2BMMmYHjConIQRwgEYhQtGAOe3CAK8yhCHxMoxw2y0YVOtEDZ2hB FgCwRQPYgAM+ZCMAtghADxpQCBng4wb5GEJ4xAEJCcijFuvwRBkiEYk77KIdsSgFAv/OkQxP+MIo pfiGPr6gCxicoRZsWEdTwMABYAhCFzNgQwOIQIYRKCsfMFgCLdrQBlNAwBzOeMcceEAIWCSgHJrY BwA68IQRmKMXiriFHR5wgC+MYAzcyEUQqhGiQmbiGrcABTReYYkAxEIVhCTFA0Qgg03wQwcPoMMT /GABQxCBBFIgRD72sQRqUEMVoNiHI+jBgjS40gUiAEQxZgAHOUzACX0gAylesQlF2MAHfRgDWZ7B BxA04gFJYAAXmICAe8QhFLCABTAsAYde4OAZ41iAGUZxgmYEwwileEIQwqEBLUyCD3K4Qj0wUI1W 9EgL0rDDCUSwgno4Qw9MeMImoGH/gU1UIQwIKIIh0iGAIIigGg+AQxVAoYo0rGES6ZBHMsAQDmFQ Qgx+gEYEZEAGFozAmiWABTtsIYECOEIa++DBAYCwG2lMQQzTwMY0xNEELPhADJNAQTCKwYg65EEE WTDGOSaQB0NA4wMhmkAAboCEXgBBFqJogjRAAARHOGIeBRBSKvDgg01gIAf2mIQAQqGPLKQhCAZo AlEFYAVAnAAaaxCAE3hhABF0oxsggmsOwLCNO0SgBNVIxw6+0IYubEIfIaiCNMQwjHx8YRjyKCQG hJAKU9yiFxs4RCGrwYu7BmEVYLOBNOAgBlkkgg7zBEUaRKCIB/igHcYIhC/KsIIq/xRAH4PogiUc IYJwREIftLgrM9KggTeI4hIcYAILrrEDfbjAlasdwTgA8AUfRIEaQZCBFoaRz2ciYBs6mEI6TCEP DlCCEdDoBgfYEAsveOELvOBFJZKxhHAgQRe2AEA3wPGGEYyiGPlgAg+cwQ42vKMWSLArLVQRgiZU oRbcCIIU6rGGN3DBDokQggDUMAE3JAMBwQhAORJHDBLcoRtf6AQViDAHKhRCD1TowCAKkY9zeGYf RejGEmKBgEgEIUT2AAInoHECOgiBDpv4GimGIQFQ1CMIAlBEB9jBijQYoA3vWEEa9JGLQkIjCf9g xAT2kY0QPLkSjtADGb5QiDAEg/8Q6zMGPTTRgXOwogBpQAIRtuEFGsygEKG4AxJUQYs0uEAVBaiC HuaAhHzY4Ra0yMUSIkENFxSgAINeZxruIQ42PKEDknBEOATABS4EgQEOkAUY0gSINORiC7gw6iYI 0AZnODkNtLBFKZhRjxWEIg4IKOQWovAMZ5QDnHa9QzDkAAgW6OMKw5AFKxwwg0tsQRhtQMYM9qGP ESiCAfKQRAxsQQt9PIEWZHgCC4IhglyoAQFXACISsHuFQpRhwtSgxQlsUIsTaGEQvSgGIagRjlyQ AT3liAUDTqAJHMgBAeGgBhFUYAQwyKMdquDANKZxjyzEAgn1CIcN1BQHUNCCEEv/yEIyWrAPeahI HtSAwfRaMI9J+CEb82BDLVTBhNXmwgfSSIUY6BADR7zhFmZwQAaAYIFljIADWFiGKxxxgAfwwwC0 iEY8zDGIYLBiA3xIQgowQfZ4zEAY3lCCMFCAjS4IAxGfWAYQarAMSvzBFbQYhCxsoAN1jIIRk9AG H1CAgkQ44BzLwIIrMsCICxyCD95YwDmocYED5AAcTljGNSzRAR+4og3iEEM8GPEATRSgC3/ABiW6 gAhECOMPXKWEFeIRjy4oAQ+fEAE1sHALHSyDGRwwgyvgAAULJAEKmVAGJi7ACAZEYBGZYEMIwGGK KHRhxpbYQS0g4YZ8oIAP9oiC/zTMgA1syOIEpDhEJpZxCEYAQRhdoEAfClAITThixvd4QRcqsAw2 SGAZyqAOGyBT02AJksAHGYANL/AHSvAC3kAJlOANViCBwnANlKCA14B2ViAMHOgNEngNL6AESrAA G/ACCzgJorAE3vAHJmAP/PAClLAAGfAHfzCAcBAEobAAopABiFAHEbAJ26AI4HAK01AIITAN5KAH z/AAiJAKI0AGS3AJM3A5j3AGdOAH4FAJFMAI/1ADJpAOFnAL45AK4OAPZHeG8HABMKgNIdgFYxAP 8AAPYheHcWgIhvABhlCHhoAJt1AFXcABXbABiLAAbCAHUHANrzAO5kB6PtIHh/+gBXQgCpKgCWlg DPPgDQ/wDTAQAYigBF3QC3LQAbcgAIMgCq7gDPpwB2MwDrKwAZRQPD5QAf+gDW3ADk0wAlogBaBw AcqwCE0XDxDQDy+ADTaACHggDC+AB5nwB8+QA9HwAfCQAnUID4YADk/wASmQAknQCO8AADjgCqIg AM8gAFH2AMKwA22QARwwDxmAC3UQDd4AB5XACAZwBftwAD2ACrpwBzCgE26ABDjQBpKAAqaACBSg BWHwDpJgA37gBNEQDfw3DSBwNICgBvxghtFwhhYABHB4hoYwBZRgBt6QCXzwDxXwBhRwAI1QA+ow BVrgB/9gCnVAjXhoh34gDd7/oAM+MAITAAQmyAeu8AAT8A+ZYAfBoAb78A3IEgv4UAl4kV6gsARy AESygAClUAhX4A3/gAmHoA1dAAIcgAd/cA01gAcbgAeWYAmgkAXDQAlQIFeYAA9kpwwPIAaigA3v MAz/kFns95CYII10CJhxeAHDMAr5kAuk4JR24ArTkAyvwAjSUAKkYAnuoAuTkADs4A0gcAZu8AqS IAtM0A53wAh+IAsNEAKMsAwcoE1PMAEs8Av54AMcwAGNsAMFMAldoA0mkAne0AYokArYUAM6MA+p QApn+JfKAAVtUAN7iAn9oAzK4AfcgAWH0AWSMAXNMAav4AfysAFWsJWLkATR/8AIpnABV/ALXZAK fCAMfMCGHBAFi/APQiAE8eAHtFcMcDAOwjANq9MIE7ANEoA8yNAGwxANm1AL+XAFlxAKfZAEfaAl QNAIL5AB4yABzuAKUEAHL/ADbqQAP5ADBWAMp0AFEhAGpmAKnLAOxYAEd9AANOABjyAG0CADPSAN MXAO0XMDe6AJnSAPIzULnbAHoJAMmjABnUAnv0AGkGAYbqALmGEH0OAMR1AKv8BinJAIwOABhfAj MDAHJTADqCAGPhABYeABxHAGMXAPXBACMBAKaiAK6bAG5jACPwAJaSAEQzALkyADCQAMtaANwyAO R1AM02AaqfAOtvAOiWALdP9QCktFAvTgBNwgCP2BCw1wA8EwDFSADjGwD89QC80wCMSwCzGwB9yw DvQwCKdwAJwQQ99QCo66C7rQMsSQAyiABaYAAh1gAAiAAN8wB8SQDI2ACgACDOLAAIX0Bn3qCbNA BHlABbOgBSEyCkthBF5ABT1gCrbgCKTQCUMzDIzABjFwBOWQCuIgAEMgEUU0A6fACkawB3vgPGcx By1TCZ7wCKegC6dwCbqwDT9wBHvgQzdAAqUwATTwBRzQAzEAA7oQCCTQCfTQC4WwC8agBg3gDs7g C9YADPTADo9QHPjwBTCQDQ/AC2jACXnyDXVAB0dAACMADAlAAz6gCPKABC3/8A2wEAB9AA3m4BTv AA2tAAM/QAdsIARucAfyQAQwYwSzJAHsQAxZgA7EsATFgAU2tgSqAAY7QHG7AAkKIAEtcFVscA9N cg74UQIeIAj8ug0kEAjJ0AfkAAwtqgTWAAYHAC0esARcsAb2IArsQA6kAA1SYA3skAOrBAcTAC2j 0ADIoAU0QAC7cAoIwA96sA5UVg6o8AaVEAgycAqnEAzB8AWXQLCFEA5L0A4pVAq20ARIkAX1UAwx 8A1nQADjQALGsAfrUAjE0BLC0wnWEG6WAAwo4A4xsAuKIAnA0Lad0I9HYA0kMAfv0AMIkA1wgAJ9 agKcoAOncAQqoAvzoAZb/7EKWrADz/AKfOAOyKAD5KAJ0HAA6xAG+wAJ0MAJXzAAPBAHw+AI3MAL sPAAxPAD+hAJWaAKlxAH+aAP3EAHmfEN7aALxCABqBAIpcAktOEBZIACATAPlgACDZAKogAMidAG QyABZEACxCAEYaAKuPAGjgAdgOI9gjAAqCAOWxADNzAAYsAGQ2AOluQKO7AJgBAABTAHXsAmVfAG rgAM5SCtDwALz6ADXeAM08UCnCAGqHADc+ALcUAHCqAP9NAOtKABhDAmPWQE+qAHuqAKWaAPS6As xDAA1uAG25AMKrAO4gBB5YAOuhADZxAMeyAGsHArsPDAFCABaIoAFtAGAP8wDWeQCIkQAENwCmJA DgFABMYQA6ygCQ4wDQFwBpFMBeRgB35gCaiQAHrwm+IHDDMwBLBwDK0QAoGwD9CwDx7QCYFQBmCg D9+1pEuwBGeQD7ygCGdADJ7wAw7MBffwYfoQC3tQD6XgC8bgCehQCftwBEOADlmwDkNQC9CABWHQ DmDAEkUyCgtwDX8wCYDADiDQBVWAA+bwBaGAAO1wCfQwDF9AD1ewBYzwBeYAT2oADvLAD/agDUIA BOPAAyEAAHRQD3egCdIwDEJABkzABAwgA8dgAFmwBEgwBgYwAX2wCSLABRLgBaWwBN2QB9BwDGtw ATgABgbABt+QBe1ABS3/cAndsAlcQAbPYFWk8AHxgAX8gC8nAAXZgAOD8JtfoAKoEAA7oAabEAGk sAX2UA7BAAepkArzwA49AAbPwAHZwAV0IH+5gAXQEyJ1cAGcgAvcEArjIAavwAmmoAVw4EFYQAEQ AA2kYFciwADxMA6BO799CABvwABb8ApcYADUwATdIMb6QA0cAACqoA9cIAKVEAy/0AEgILyaMAkU UEim4A014Ad88A5s0AH8oF1sMAPmAAWSyArPsAE7wA7sIAeRBQ2G4Ad5IA9wIAmJAIr0EAoa8DXQ UA3mBpltMA8GEA5p0Aqk8AYhwApUQA9pkAN3sA2/QAvhkNs8YAeCxAk5/2AHTFANRTAFMcUHzRAL X9ABcrAJDbkG0FAHDCAHspANgDAIyNALExAO4SAPTmBUnHALjQAFD6AOC7AAFwAF0vAG4IBeuAAK tFVIdcAEl1AMAiAG5iAAJ0AGcNAGepALtIAB6SAL9xAAOCoPijB+tlAJcBAH4dAKtKAIQjAJz1AJ KxAEuMAAtwAFGwDarZAGzIAL9hUCcbAGuMCYesAAzbAGkjAPjiAKVcADdGBXvPAKAlANK1AN1VAM zgAGclAMDHAAjEkDldANdEAP08AOddAHJYAMVaAIUdALTYACO9BFjuAMg6AJ6ZsO6YADjTAJb2AB xrAC0OAE0wAM3zADnf+nAxoQD7zQBDPQApvQCGKQC8odCaoQCw9gCvywCmMwB8nQUCuwX32QC10G DbmgWprAqN0QcrRAFIpGD5XQBF9QAN5mB6+QAwIgC/gQC3n13nbQBKEACtwABpfABFxwC3TwbgBA D9zABU/gCGBACJXQXksACkQACVIQCSywD6laBVUABiwwDGwwCGzQBYlwAIPEACyQBSvADOHAAudQ C/uwD4AwCg+QC5xQBxNACHEQDDtxVnmQBgYDDfKgCb2gCXdAAp6QDLwQBeQwDwcwCnSQC71QBXQQ BIpwACXAAIRwCuyADGMgorqABCuwAkgQAiNAB052aKjkAivgAqEQAkz/oAHhAAinUAjl0AKLFgyV oKDbgEogRg9fAJSycICm8ArZ0HXbgADOQEb0QEom9QwrcA9yAAbcAAiAEAlLIAIakAdBsAn5QANm wATmJgKqwA20wA0TEAJk1AujoAkSAAY2kADkUA/QMA73cAeRgAD6IAXboAFeVkgnQAjy8AHc8GHb QAhNwAFaEA91ldMwngqVQA2q1Q1vAAVaMAbUUAkGsAk80A5k4gLdkAv1UA/dEA4MkAvdkIoIIEhN UFNjwAyrcAyc4PljoAHMAPhehvQ8EATsVA1BgPvMcGpBwAzxtQq8YFelvwIITA28pgEY8AxiwADO nwOpAAR9UA1PFvit/7ACUvALsUALzaADdHDYlaAGxQAIudBfJ2APktAGy3DW5XcIeHABY/eQBiAD k9AGcOAEF7AMAAFMiRIzTgylwGRKG55lU140gqIDBR8shxA5iTJF3qVsTxohO6StV5caAqY4GXGh BB1vmfy4MlMFCpRJphhVKhRoz70lehI10gWGQr8Lts7o8SHAR5dsUC5sotHFjZpbn/otioapXxcl GwjgcfJvEaZoFdRh9FYDURQywyTBSkfq0B9LwFCMu2ahwj9EUIBIG0WBT5dB2kCkq2PPV7d+NczY AGcokxhzicTIinXlCaFYicp9gdJo1CRslkxMiaIonoBRpjZRA6JN3f+UT6Zu8VEiLMqFJEvK1LBX ok60T0kMHTcED3mdCn+wUUL249yLZVE+2btw4VAmEzX0uJpUzIkWezpG+UnCiAyZcbKq6MADJcIy NnTocHkwbp8ebH9cxevnLC4msMMcUcJYR5ZJEsEHFCeywiTCCFOA559M8MFGGD8yQaESPyhUDh4K kTOkDnXsqeMab7RRYgETvDHjGhmvCUPGP7zx5poXvFkgCpm6AMKPOMg5ZYlxogGnEieaoOKPPxYw xYQMrJhCG1nGaSYeIQDxw4kG3LFEQR/ikSEaf5RRxp9FlPkHCj8kxESZTDI5AxhftlBmSm/4sAeK DFxZAJtMkoOnUEP/TZknG+jiaaQJMxbg4wETGrklBApeYYGQMTZJpY1T3DDFilg6ycARetpppxZ8 3pnHCUQ+qUSVO+5wwJIEqPgEHmUoSQCbBGRgIA0G+BFhjWbs+eiFC9RRoj8lQHhhAyv+gSdCQwkt NEJt+GDEgkbC/CIVV1JRIx9+TBGmABkaYUWOAVARhwYHQviiiVtiEWOBBQhgY59NsEBBFkU6YKeY MQxxooBsdNBhnEeDMcMKH/4YJp1DFNiHFk1SYcQfCKORQQ9LDjlkimUaEQaPCvpYRod+MEkhZhH7 ycSMNkAQJZJcchkEiBf+2EeUDm5hZANX/KnADjl2qCKRUK6IJJJ9/2xJJgsi5KCAlFjUyMGJRcB5 hQsDuJmAkCUIQaCdc1wxBQs6fEhnmUlqSEUIBxzJJRQA3imAE0z8QcSMMBpZ5gM4o0mijxr4YIiR Q7whYAWYRZw8hQpyQKcNB/6A4g9UjFEEi2KGicIfP4q5WYIlSgnFiX7AeYMQLq5oIRkmuKgEnCT8 eUMSEObYxz5X8EHGFRPi4aIAOMw5wB5ttoEixkmOoAOaLLahp5ZAbmBHB2gekGOIBI5gx4F3SlEF mmfOOGeYZBCYpRBWAnilnBhKKeSUbZLZJBZpJCCBCvRxBkGoABSjSIYG+NCDZuivHduIgQPWMI8G nGIQN4gBKuihif99kAAVbOABDIgBC3d8QwbgOEIpXhGFIaBDCyWAhgxisIsG+KIMdBCAOW6BCmBk 4w2PSIA7jvCNG3giALLoxCagwYk+BIBBYyjDHIYwAzXUwgil+EUgdgEDD9BjH1dwgwqWoAJiEAMS kNiGEToxCmi8wx0D6MQNHvGIUnjCCPvIRwtaoAMfmAMds0gAGeAAAzkOggruCAAKmlEFdjCiGJqg gyAEYQROPGMaTdlACUoAjkAMYB3jcMQp8JGDaaAiGFdAwiVmcQQCQCMfcdiGIDzQgy0AwghU6EEp uKALBXhCBS0Ixje24YZCkAAMviHBFk7AAWsIwhoq6EQLWFCOXUj/wBHlSMANgpGAGfQCBkTwxRCs MYIiQOMfUVgDOHSQB3CE4gH0SMYPdpGFJVAhEeyARhXcAYxZOMAW5ehBNgZAAzEgIx4NAAY7RFGO Z9CiDDDQAzQQUI5c8IMK3xgCMYyhixYcAR3BKMcZ5pAMfaiiEMQgAhj0UY50TAMYRvAELIIRBXlQ gQeTOEAMAjCHbMAAGMBQADXdIA5gwKATs5jFDaxxCmhA4xjQAAcxYNCAIzihA754RDygAYh2zMIX sHjAI2aBCmnUgR1DgMEewNAJWKADFTuIQABukItmBMIX3KBHCG4Ag1KsYxP5AIQnbrCJNyQDCXNI BBvK0YBgJOMS/7tQwB5soQE2uOMGxFgHFRzxiCPEYaKw8MQ6SGCEAezhDmUIxCMkMY1OAOMIR+AG NDZxgqZaAxwFOEIzoPGGb3hhGmFAwjqEkAtAWIIRDUDqA2IYgASQQyKoCEA2hlEMLXjgB0wgRhmO 8At0eAISLdAFKGpBj0ss4Qm0yAU1CIEEKYDBEqiIxT1kYYo3+mIXvjhDDEhAAmKcYgYxGAE5gFEK CbBgDrtoR18DkMFiLMMDuyAiNErwhSPMARq58MUAYsABWKAAFyjYxjYI0IBHSKAF4oDGHgZwBH6c gBhn2Ecy8nAJLhRDBV8YByqW4IIT3CEZtSBCKWrRCU/MYRZI0P9AKWCwjj1Aghvb0CIMrHGEZNyh FsAYwg3a8QWvGqEMxijFHjzABgIMgQ0T+AUtOOCOZEADDT24hCRG4IcmlGMdBcAAFVBxgx70wA4H EIUODEyDXrBBFq2QASy+oQgJ+wIUebhBIUrRjWaoIASo8IUx7kCHQgCgFEa4RzO4IYgz6GIdwHBA Kc5QCyTUYh+luAMY0CGOXQQCBirwwBwucQcEwMEdcwSGDeDgC2K04KhKLeYNvvGNARhBFbLghw5u 4YVaZIEQcpgBDXTQg0fAwgnP6AMs5qAJGtwBEkI2QgxKQI8OQGMJHhhEMPIRiSuYQg8xgAE6mrCH M7CiHuSghJP/KCEMHVDjEpd4de1gcI8hB0Aa6QBCCWQRgzOQgAquOMUVElFBHZDDA+KIwzp2AQsJ rNLJ03gENNxBAwkMYgu8QEKxma2GZAzAA0cABimCsY4z2KIFAFhHDyawi0FAgx89YEUnXKGBKnji B0EwwjckMIQ51EICUshCKXZAglOgQwIOWAcC4sCBdWxDCvqQQgtO0YADkEMPM0jGOTyADi+gIwae 2MaU0fGIXZTCFg7vgzta0IFZXAIdSv0GMkzwhAIMYQ9NIIAEgoEPLQAAFjFQgTgC4IEhIMMa35jA FmKwB10UIoadEMcTcAALegzjHETIQiBwSQQiGGMbwZBEC/J2/wZU/CAWDyg3AM6wDWpo4QAPkEcd riCOITggAEHvwS20II5AfOMcpxAhN+6xCxCwYRy1+KYmcL4OcYTBBuJ4Az74AIsz+AIYsIAGI/bw CBrwgwFDGMIsXAENaXhglXqAAaMjgAMogXD4gXboBUgAg0mQg2SIhHM4By3ohEpQABvQB18ohQko hSAjPlbYhyxwA3TYAwkIAC9ggB6AAUgggBi4ogZoghlogGlwBXfQA3l4g0bYJxg4hSO4gQEgI2AY AHnQhCEIA3tggFFoBIQKAFKQhx3IAmtoAEZoKm7jgzboBUA4AEVggUfIhlPYgwAABzCohVEoABI4 AWvQBGiohf9dEAQDQAA3CAFaIAZfiAMFcAMpGAMRWoJfWJ18YAUjuISmSYd0eAAQOIIe+AIHYAdH GIJLcARYAIdUaEQS8ATWagdjCIQhcAMe4hQO8AJicAMuoAFUGAVUGAZokINH2AMx4APMCwBykAYq UADfMgVZsAcyaIARULZy2AJo2IIj8AVd6IQ+OIVdWIJYiIEf4Ktu+IVSEIEJMIJkOAM7wKJ8QABj IKIgEAV3SAAS2IU5CLFk6D1ziB9RUAM1mANBIIZaOAUeMAca8KUw6ITeOoNOQIUCEAFycARHOIN7 6AEtGAFZoIIruANyYAN2gIVpiIJi4AMxiAEtGAZb6IEqWIf/TniAKtiEPRCBAugEKogBGwCCYqSG TfiBQmiBx5MDDfCFdtAHXXCDUlgCfSgF3XuybWiHxkqwTtgDT2gBU4iBHtgDKNuDPCCFbkgGdbw9 TxCDCSiHeXAGciCHRCCHRwCAFriHR7ABLWiuQTiQTjAzPSiBeQgDWKACPXAGNrAFfCiEYDiHBhiE NRgEPbiBLGCAE8i3MygYIiAGHgiFMzACSLAFL8gCF9CFknKDcACAYHCBdvAFX7gDVcgCEoDHQGCr FkCpAtCFO8DHZjQGBYABN1iCXWCApoIGDKgG0sSAVsCA1GyqVmiFVciDauCF0oSGVmgq1qxNaFgF XpCH1sQA/9J8TdLkBQxYBdT8TV5ohTyAhmr4zdwszVbYgt+0zaZaheaEBg1oKl5AztX8zdV8zeoM ATPwhgwwAUagAzVggX2oAmTQglEQAnbwgiXYBw7gAC1QhHmwhERwBXKwA1qoh9OsBhdgBtKsTR74 AxtYzlwIAiyQhRFoqi0Qgnlghy+Qg0QAAxE4gW24gTM4hVhAACQwAMiEhCyIBQm4Axeghn3Yg3ag hje4BfvgAn44hjoYjhpoAjkAhBHQgSTwAy3Ahx2IAUsQh1AgA5HpPgBwAFn4A2QYh14YgxNoBi4Y hQNQgGlIhTHATgIlzRqQgCylgBIYhQ44ABmIoQfwgzyohP8fyAKN6YAoIIQ72IdAKIV7GANmSAN9 yAc/DAVqAAUXqIcTUINB8AYfaCo26QNauAMuKIF0GIEnMAdZkAU+0IMQyIcOQAFJcAYbeAUx4AAg kNFMaIR8yIA/yIZgYEtHIICNC4AQyINWiAPW6wAhQI9GYIcn2IR34IBmMIUHWIM3wIGGeoPR/AdL iAEiAM1JGM3sbIZRGIUmEAM5oIY0SAPslIcQ6IBiyAdeaAYGeIBsQIYXcIZe6AXSkYBaaIBEmIBb OAQlwAcgEIVG0IEIeAUC2IFNuNF96IUowIJbuAVeAIJl+B58GAgqiIMC4IYgYIADqIQTKM4tRQEx GAMG6Rv/UuiDQTCxZNiGesgFbtAHEWiCEeACVciF5FkCaggHp1qGZlgBLnACPygBHpABeZAHMhiD PugDUlgDeQAHcqCBBAioKJgGX2kDFMCBQiCHeGgGoE0EOOAAEOiCeHCGGbiEYeiGXCDNNcCAJ1AD U2iGDggiaQgHEVADA+CENagEMPjNHAAYKiCEJfIDaDCBBcgAfdmADdAGERCBGOICJjiBbBADR9CH ptKDR3CHRpAHMHAAHMVOUmACAwiCcDCQRvABUxACLZiAcNADEACBAEgGMVCCBOgAcSgNWbgAiGCE PjCFPgiHNOCFVQiC06SGJbABU9ABcGAAWggCeqACMRiG/w5QBDIYhAKoBBmQAWTABjyQhThwBVig V2roBtl6Bi+6gmnlB9JpBAdohjw4gUigBQMQgTQABVpYgwhoBjdIsGRYAlighEDTgTEYA3N4B1dQ BDoAhBbYAVkwgaZSA09wBFmYhgwgh2fhB0MwhVMgh80rgxWoBiYAgwPohUNwgHNggTcQARaghnp4 gg4gA2P4gXwAATGohjegBin4AyuwA1YQgXpw3ydgAlVYgjSohiCohziwgnm4BzvoRUWghzhIhSrI gzzoBnnYAkxAA3iwTWbI0uLkhE1AgCyQghC4JwcoAHKYAUvAhzYgA2gIh32YAXyQhS6QhjVABlnA gSowhf8R0IQOGIFimIdUcAJT+IcH2AFJYIIgQAFsEINRGARLwIZdgAY2mAUFYIX2gANuMLhTEgEM EIAvsGBQSINKYIUg0ABmeAIkUACWDIdwIIMsHIUT4IITwAI4+AJH6IBnqIJbyAMOmAdNkIUbWAFc YIAVWD5niAJE0AIh0CpwUINqiII2kIX7HYRemAcO0AQ1EAFC+Cd6KAAwUAMy+IJ3OIUqaE9QyAJo kIIvs4QhGIAZ0BQhYAB5sAEBMAUt4IVuSIPpxIBk1dIYIgQ1EIA1OIFcUAN6UAN+IIVmuA1kYAE7 oF0fwIITYABRMAMTOIFKEABpmIdHLIam4gdzcIYvwIH/USgGKmiAHmADS32HdyiHOwCFmLsEQtji xLInDtgBWzjRxqWFNDiHd5ADEXgDFtCHSohoHuCGJYAEKZACF5ACN9gGfbgDPTiHfGiCLwCEK3Bk DQgC20TqNzCHbLABEcDOVtAAA4CD+VrOPi2pNKAFUegCFPgCGIQFQCgGH9CEJWCCXNAHBIiEWNME ObCFe+heaZCEWICFBGCFFdCHUNADRwCDtRYCFpgVW2CHfYADcvACcpCFswkHQsgHJkiDO8gCJAgF ORiEEHiCXGCEKOiAfLADLBCAKpCDNOCGfQAEFggFc6CAIuiDB3gGOHCFHbiFV/CtadCCSgmGNhAD aGCA/0bQAzawB2g4gSdY61pwBGd4B3x4BXk4h1h4gkogBEdohGbQB3oxLwTYhDpQgyVAgEv4Miao BxdwgXtogS9AgmCgB1VwAQBgg0IAAxdIA3MGBEcIBgM4F/KKBRGgBWowACZgAlAIgtqUgkggzRzQ AyoQhx44hXaoh25AAlAIhyAIgjvQhyA4BnAoAdzxHRRgAjvggiDQh0uUgju9gt9kAD3oAQ9QgR84 g1LYB264BBrYATVAhjDYhzI+B0cAgWwggFNIg0goB3wQBwnQgx3oAjkw5rGhhRMwABsQAxsAhFKI 7F8AgwLQg32IA0CohyDohiuohFzQABEwgFtQBHBoKv8GkABM5QZaeIJeJFAM6AYmWIF6wABgGaY0 wOBKUM51XgMGIARF+IRjCAIkQAAuyNJqkNZcCIFnwAImmK16YIBxEAY5YIY8QAQOCIEuT4MVCF8R kII4EIM+2IcvuANeeHAu0AQngIZu4AZQwOlq+IBxEIFuYAZakIc+gAO0LAQdAAJ2EId8wIIQ2Acm sAVfiEYysIN5cAV6IIIfKAAqIKkg2AJcyAMZCIeARIbZbCpO6AZF6AVw6IJT2IF5GAEsyIc72Axu YAdZQIF3SIReRgYy6IZX0AAuoIdqqId6AN/u/epQYAZQWIJaAAMmQIAr6IZJAAEeGIFx0AIwUAUF 5gX/VaCFKqACfeiGx4VwAM10UKCGSviCDmCBx/5Q9BYvCQiFIEgDJqAG56UFUNAHs64HaggFH5AD NgAAQNCCL4iELEAVHrgHz9qGWnCrAKCCfLBzeeCBhVAHnS6BFpiBKKiBMHiHP8gAUuiHUcifLzgB YdeECOmHf8ADPhgHK/hbb7iAf5iHBfiDQbiAZTgEC6AASlgAMYiCLhCFEBiBf2AUfZGEDVgAFIgD TbgFfuAHdVgAEIgCezCBi6CDbJAESkiFBzAFG5AAELAE8HiBQ4gCehACHRCFNtADbfgDJbiGmtGR CgiJrEASJwCHT6CAJCgBStAGASgBRDgIhKgZABiH/wrYgD8AAhP4B3XIhAeogUkQAxPgkngoBQF4 BSxYBi14gD7R9dmYgNQdB2nYEw4wBz5whkrwZ00AgDCYhnegAywQhQ14hwEQh6H4h3ToCx7AAW1g gy4wAQeAAWnoBwtIB36AmgiABzR4gAcAiAtWOPypVU2bGQAglFiBZygapmjRDC0ThUUYNm86Xqgz BIQDmUpqIgkytkyTt2X2DkAxwY3aqEZ8Mk3xxqfEvxqAcjjJQebXuVj5XNEYAY5Ol0Pw1HWRRIXc ND5WGpnJQGmDiQzmmtT4tKgfphSYEOmYtOCFCUT9/B1CZA9PtCQW7NVw8oyMHw0XMmywdcTVtQwF iv/N8wDCTCFGWoSZmeQKhA0/mD4sOoRnHj42iVKl24GvB4FQV7hxYXShnzph82y1OWToUBsQBHaI s/TgQSR7fDpUOhDlQrRPyvr1q8GOADY80DBFVLYIkbApPjIpwYbNFRBGYCbtIOToTY0/JZb983oo lQk+lP6cy7dJGSaHhtYQmvQHGzlY+KikKvHgHT5EIAEGDTQsQUgXsijySjwUmGLPC9gIY4oO6kDh TRoXTGJCBcJkkEgYKAiRRD+SrMMPIvJcc00Sa+SQQh0xQjMjIwCCgA0rr8ABgjRJpPBBCdAwUoI6 y9jwjBZ/ELCPKHjAg4Uc2PkxjiMZpPIAEBYs4kf/H+bYco45onAgzD/QJNFEG21cQQY/byAzjxg5 XECBDvkAgUc6EhEHUSbYSJJNB3FQsoA6/fgBTgrwKGoIo4o69MEykwhRRShV+LDGO0oo4YoVVkgC xxtC+MBIJXZA0YgpjfQyRjPaYINMEOD4EUE0/TzwQgdkKGLHM4nQk0gGcAwiiyg0XXABI0JkAkUN w+jxAiQMMDfttPAsgocsHGCTiRA4YOGEo4sasmii8DghQCbX4CDEMpRgU848loghghrP3IKIKGL8 Q8oGSiAjxCST8MFHKgTcp84HiiSjCB/kFHKAGQss+4wABqzxiT0owKGFKQjws8w7bIzTRDEuvDHO /z/MSaTyFLXEYoI6pGyyBiPxxCeufIZAA8UChnyQhDr28NALICfEQ4k3pmxyizYgJKLNIZU04oM6 FeBhTxMEHEHMEgaA0kwEHVgSQBy/3DGOFa9UYs4UFSwjzQimWPDEBEkYUoEzC1hiSQt7yNnPP3jw scwnlpljATzTKiMGK450QcEhSC+jjAUXxJMIOeZcUMEFfqyBiSGLaCPLh668YF8NY7zQBjJjDJ6E Tc5MU0skyCTCRj4VaGMEKi63I6AcAJhTAiLS1KJKE7e8QYFRfqRgCAXkoBJIIYikANG0KahDyT+G MAePMtd0ql4U0BzyxwErkKLNC3D4sQh8jI7L6P8HfgxCCQcYqPMCFhcgkg4QtAGEeGwACpPoAjDE IYEXZCAKNXggAHZxClYA4AwNIAcAABAFE4jnAj5ABBzO8AMSXOIBFSgcCqCyiCQ4AXspqIA3zPAC CvgBLBfQBh+EsYFDCEMMNVAHc8blqJ9RQhp1EOIHlOEKMfDBFak4ACD4YYo2vMMc9rCHBSiAjGlM 4xxkiAM5/jCOZrAAABzQATUIIY02FMAAPJgDDCawFiyYoA2ukIYQ0oEFEVjABJPwARBS4QcEIMAC /VCEh/CggxJYYBRCAMdGtGGDBUgiEym45CXhgclyabIfL6DEGxphAxHYoAvDAIQlCNAEIDTiAk7/ OEcTUmAOSVhiHpkwgz3+EQ9+jGEMmyDEHFqAhAgYYB8lIAU4wGECJQhDHW2QBAc4wEQcokAMHciG DoSwDRUQwQUM8Ae1IuIETbwjA3zYwDLGYQIT4K8jnAyXMi4wASCo4QRrYAIQJmGJBdCiD6EYg6j8 kQQ3EOMMl3AGClBgiW9sgxuQuAMJKDGJFMSDEBMghTomkYkIbIILCDiFLcCQjxE8QwhCAMKyogAE KGQCCGIAAw+0MKh4JI5an3iBNyTzCc5BgRJYsAAllECJQ/RDGfE0AQca4YoFpCIfIYjHPxhxAloI AztRiAIF4lECGwiABTawwx14MAlZ7EMNNDjF/xWIwQ441KIKyUDHJZrhBwNM4BX8oMM2YpCAP5SD BnwwgTagkI4aHOIB6TBBJrZBAEqYAQhviEB8avACbZQjBPCh1iIW0Qxn/EEWF1CHNGRRAieIQR11 KJdYkvCKJZQiElHgAyNSgQJvdAEH5lDECL5wAHBMgAx96IcF1OCGEBTjCc2IRzu2EYsr0CMYE8AE I8qxDh0Y8hMCwIEmmqCDEWB1BOc4xLKQEIo4JOMZYhCGFYgKuGFEwRTD8ceWTvCGCYAjCfCrwCdB 5SOxbNICBZiGI9rABy744B9TWEAblhENdYxiH0gQQTxwwIIrEAEW4hCAP+QhhwaU4w6EQMAPfv+h DEYgYBsBcAcwkoEIc3xBERSoQD/AwQI6PKEWDqgCDMqxAA7w4QgjgAY1soCAYcTgBo9ARQ6gAY5x cKAJNECCJ34AA3NgYA6wmAEqyHADXzjgG+D4xhHEUA4P7MINW+gBMPZxBxhcoRC/EKk4QkELGAhC BFdoxzp0sY4CMIAeYQCEK1DhAWAMIAGjSEcCnJEKd9wgAB74xhYMQQcNpOMUxCgFHDjhghiaAQ4t 0AAnymCMANCACTToRSpaIYpEAKATsFDAEZAxg1dAIwzfWIceMLCDWXhiHd+QBwEG0IkzlMIFZwAA L+iAjm80ABC/KIMvtgGJb4DBFFqwQyB+oIr/H/jiDXUYBTICQI93DGEANFgDLNwxC1PEoCT78EYv oDECaxAjGZ2wxjR6wIhXyMMIZYiBAgSBg3FYoxznmIUC8mCDHbijE76AgSd2oIcB/PgZ8xDFERQA jR90YgiAkEALOhGCU5xCBds4gwBuUQ58lAMUqtgGCbYhhVNYIwHsgAYcviEIGBhhFuKgwSMEYYQz HGEWjijBIzxwCTjwghyPsIYRgOGLGEjDBy2YwyaiUIw8QAMDirgBMfxNhFGM4wnF8MAj3lCOAYTB HcOYBA1u0IBUJGITORACIJwhDzYkowzEOIIRouCFXZzBCAqYgSM68YgGECEZe0ACDIhAAiOo/4AW odhGLk5QjgTgIAezQAU6JDCEPfQiDAUYQTXw4Y4hAGMWBdDDLjyQgHcoYhpD+IIfgOGON3ygC+5Y Qhl+YAC0a4IX5nAFFJARhkeYQQI3YMUOTNGBAOyDDTqwA8vDAA15eIEYxoBBJ3AxCBiAIQboGAEc YGGLybdDF6rYgzGMMQt61EIfodBEDrpxj0CAIAypGIYOjAELHMEu7IERwMAl2ME6GAERaAIfWMM3 BAAXRIEluAIHPMIWKMIEQAMHkIMqCEIZgEIfDMAj2EMUTEMnjAI/9MAQVEEPzEAxDIENzAIV1KAn 3EDU4UMQiIMQ3IEg3AA6cAI6HAEAcMceEP+DMzgACbCAK+yBL1gDEcBAMKBDKZCAGryCKLjDESBB O3RfKajAEQyAGEDVNMxCDMiBPpSCNdygB1CBALABADzDB+DCjMDDHExDAgzAHAhCFqjCKYhDJ5CC DiSAOwxAN3DAEAzBOLDBEJBDIqTDPAADMDjAK+TCKfygxoXAIyCBIZxADHjAcejCHswCAlSBLyzB O/CAKqhCIJCABMDBKZTDA/yCUFiZJzTAJczBGVjDHbCDEgBDL+QBFIRBMqDCDRDBEohZke1CAiTA PMzIjDSCNfzAI/zAEkiALdBAIjCAECTALEhQOZxCIpiDLGgBAThAPLADMHRAF8xAA8QBJJz/wztA gwYMwgS0QQDYwizQ2T1wQDKQQDtcgi7oIhWkoQrUQzB8Qy30gSTGAO0wwBbowiXYkxBcwRnsATLM wg10gifcgwKcwSwYwSnsQifIQgP4QiDIAzTUATQ4QSwQwzoAwyuMAit8wzBAgx4QgDXcwBk4QycA wyMIQa0lAA9g2TsAQyoAgDhogCe0QCzwQwCcgQvowSU8nB54QDh0ACAQwR58AwOoAhh4ACoQgDwU QjnsQwicQxzogi/YwSZ8gweQgBc8gvnFwEVeApbBgAqcQTksQScIgi88AjKcwg0Eggd0AjQyQATU wBLUgQNYwziwJBe0gwd4gBjQQwI4gAMg/8Ma9EAAfIMtXMIRBEAnpCA47AAwFAM00EMMnIMXSAMx BEIDtIAaAOEcGAEtjMI6eIIINEICwAA70MMvHME6UEEgSIE+7EMhBMIesMIRxEAn7IEC7EMM8Nou CMIPBMAQsEMwWAMJ7kAgkKAHWMMb+MAWsKQv5MAMlIMPQMMWbEIZHEEDnAEwcAA0sIIrPMA6DIAv BIkOPMIRzEAfgOYORIE8KAABrAMojIAvqIARXEIMzEEpxEAhnEIoUEEsBAMRRMIdtB861AIdzMIs 7IEccAEnjMIDkEMYROURwMASlEMyQMA0iIM40IMmNEAhoMNO7oItDAAwkMMriAEqCMI9vP8BG6zB xOkANIyBdw7AEdADFuRDDORDA/hADxxBAvgAJzimJcwCK3xBMhCABLABP5ACOdyAKiCBMczBKegC OpxBMFwCEjwBPZTDL/RBcemDKhBDO7SDNQQCC7SDLfDAENheOYRBGHhBXqlAISTAERABNYyBFyRD OyhAKFADCeyCOASANWjCFnjCAGwkNCiCAgyBKRSBOJRbAhAAAaCADqBDFjCBEDgaC2CBKxRBIuDo IOiDLYhBJKgANEBkPlSCHATDKVSCJoyBLWzDHYwkLVzCL7RAIBgAAJSEG0CCLhACEvgCEhDCNsyB J2yDKvDAGdxAGSBBPoRCKLDAPoQBSj7/wg2gwhDopRsUwCyMwDG4whHowz1AQw58gy/MAi5gwREM wRNkwzfc3C1cAgl0QgM8QgAQgBbIQwwAwxCAQx1sAxJQQTlUAwnowwjcQCz4wBGoQDKwAAncQRy4 wRmcQwx4gQIYQTtggCaUwin8gDFkgRSQAAkUADB0Aj0gQSEQwBmcwTPMwOL9AgkYgy6oQAOwQQKw QjqQQ4NWpyBsAzzsABn8gwzUQSwMgAeoATSsQyewATnQAD/QwDTEQxrEQieMZpAwwCP0QBxAAylY gy7IgzUgwx1QgwxsQzIcASqcAh14ATvMQTvcwCVoQDW8RC2waQjMADoEQicQgQR4QgHs/wGAzYA1 oAO3lQILXAIMkIERxN4RSAAPjGgBDMAQNAAJPAHBBoIKgMAw8AHGykIYjMM6OIAehAEAoIAjFAA7 kAM+KAAstAAXNMAQ7IMIeEEnmAM0lIAKhAM0lIOOTgCpisA5EEMZfEMOFIAK6EIMwMIXEIEKwEAk 8MA6rO8/SoA1FMI8oAMxSN4ZdMIshIEutEMLeEE5eIEE1IICnAMn7MAQ7ILgHsEjkAMYeEJI7oI1 PFznsYMNqIEqUEML1EIcBIA9XME7RME4zAMODEEhDEKHGYMREAMkcAAjIMOPaeIptEATgAIhpEID 7MEp9NI6kIACcIMNG0EpGMA98EAy3P/DKcjBNZxCKXwDKlxCIHhCJ4hDDwBAGMyBLhCDJ9QACEhA 253uOiSDLnhBB8TAI7QALARDHyiAL8BCCWjBKFABKWgCDPxAGuRBNWwBJ/jAOqCCELCBJtiCJ8RA F/9AMthCMsDAMyAqNMgBKlRCKcSChI5BOHjkFP8AAgTCGeBBDGTAHwRA+8iBETQtDLzAEoirPhRd COwAOYjDLowuPaxDC8RAMJQCG/yL1pifIBCDK9yDHTSAyUnAIyQCNsCCBygCNNDCOsRAEwzAAOhB ARijLUyDKWgCKyjAAKyDJojBNJRDAGCABpzCN1iZPJwDHKAhD6ACLOyDL4QCK/TAPcD/wDZcghqI QSDsgzwQQwwAQBCEA6UmrhtkgRvkQzmQwD2IwxskwBCgABYMASoQwSl4ghE06CU0wDssQCwEwA30 ghuiQwNgAzC8QxWsAz6UgCZ4AuEFQCq8Ahskqg1owB18AT1oASPsQ8E+gAtsw0oGAA4MggdMABec Ag1AQwccwR6QADGUAytkASF4ggKswz1EApvaQiCAgjfvgCqgA5ueQRygwCzogjgwoBHEAAyQwxH8 ADEcZg40ggqQgDP0QBMIwA1UgiS4AwkEwiw0cTpwALOhgADIQTlgwbidQgEgAD20dRyIZSckgJfw AxyEwg9cATSIgDgQwCAoIByQQzmI/wAJOMA+fGw5/MAXPMAbXEI+7EEwzIDJ6cM5lIIbcFMwSMIQ UCoSFIwHwAAMMOcQeMIj0EAl4IMHGMNOvrYHeIEnxOIIeYJ3usM0OMHxGcENFAJrWYMckIIW9EAp NMAoBIBBI0IDrAM03AIMSAALEAE0+IEB21lHnQMdvAM9yGwhEME2ZEEg3EA5RAI1bAIAAKwciMAZ FEAj2EEyXEIi9AA2TMMUAIMg1IMMMAApMIIi+MAytIEXFMIZs5kAzAEZ6MAFFGJdX0ELCAIweIEi kIEjyMIeMEAteEIhWPeMxAEsiEEdOAMPOAAwOAI0kIEgWEMS0wI0rEEMiAMW/IIKLP9BM6hANsDB OiBBJLhAJIxAZRHDGPxCmd03DCTDNyhAQOuCJ3gCzxpBMZyCA6xDD4DtGcQAEQDADNDDDLSeA8xD HlRAAUNCAKCCMdK2O4jBOMgDP9hDuj3CGcgeLEDDKAzALARAFOTBELhDArgCNKAAMNBAAzQDDPCA AZSDHORBHhhDJNhBLWzDOZyCI6RBJxTCOaCDh9WfJ2goEZwBCbhBLfQCPZCB5O0BAASCL7RDF8zC Xq5DABRCFSCDChBAAkTBOzCAK7DDOjRAAhADCZwBDCSdIHyBNXRCBwADG6SDJpxCAxgB68UDNCTk DdgANLxCFJQAI0ADHcq4FnBDOfT/QgMMAD3gggq4QRTEQBzkww0cAC+gQxnAQDEkQ1TXAhOIIhJs AxG4AQIQgwrQQCcgAQnIQSuGwgmkwiOsgzgcAQR6ZhTgwxnAQicsARRYAyGQQOeewlcfoDX0ABZg wZk+wi1AQTxswhCkAjRACRiggi/IljRMH1D+bDpMQBWggiYEg72NAwAUAi7AgiCk1RxAgwH8wB0A QDJsgwQ0PQmEAjoYgxQ8gcm9xBUEgirUwkbGawDQQRMUQDmwQzF0wg9A5zrUQipIQgA0ARH8wA8A oJSpQDjCwBC8QgH8YSgY7yMUwgM8QhuQwhigQpa/bTm4AxyAAwGwQQAAATTsQA/E/4MW2MIZ/sKM gMEAlAIReAIXxB8TVMI9hAA7hEE7/MA3EIMIDEEgzAEo7AE6pGkZGMHWQBkssEMMcNge5IMnnIMi EEMC0EAJWPUuIIAINME60IEN0MMGxEAPwMIwJMAz6IEubMMVOEMYTH8bQAMBBMA6QAHc5wcIiIIl BEIsUAEHzMMDlMIQCIAO9MAuZMMHQMMM+MIedIIiIEAyOAIh5AJA0HLT7kkuB3buJSulCh2MU+iy KHh0z56XR8FqubnkZYgHXzBwAEtl6UclI75OiZIHr4Wnb1m8iDvi4JctR2MgJdMwqEE5eppwUNkx j1wPR8DaZBr2aBq+ISUcDTkyLf/VIHMNnNXDMqSUp22hBCjYZUBEshgtCOV70uTHLxwQIUEKpiuL JhiBArUDdkPFHHokztDg19VNMl0wyvGC5ocGjB+BHDR5BKzFl0k0zuzbESDMNhIEFFUhl4AGAkDi 5rGjF+8ZuwCd8GmABAtYgxiKGm1ytkcEshi7NKmpBSnLjjkkjKjglkxGIRJEzsDy5IbYmSWEaEVC UohZHCOQAs3qQShbgAf60N2IBa2PkR+6FOi61GkYnR47okwLE2CeKBriWIChEzAcSMUGGhIY4JRe emAnnipqia6nckZh5xx2hvCBE3zYOGKTePAxgh4V2EhmmywIUUUVSNxQpYlyuLn/A5RI1vEkkHtA icWDXdpRxZgyPJljCXrC8IIvB06BZZ0i7CjgOWJKAcOiV3AQJZ87vmFnswACAGCI+gJoAARLyLln nTOcUcSLKhxhgwYO2sBnBnGMXEePKkRA4hQSxImCmBbagSWdTsogZJ9YyrkHBmOygGSFbrKYYw4i ELhEgTm+2aadUs7pZhtiOqHhkVmSaWeXZJogxI5YfoAhllquIAYWeeKo5YRTQqllBABOuKScL0Q4 RYF2QhGHHRDM+WIQOIBgJYwWTmlnHxkSedORHXo4RwYfCikAHWNCkKCFWsLJowB8PLnSk1JGoKOc FkK4Y5s9fCGmklPuqGSOZJK5/6enGABoZpJ1FLClkC/04IYbefbZRp92uElDmmuuaUQIRQrYIRsu yChGkyeooeaKK8ighRlmutEgiFz6mECDPHihJRtXqmijC3OYcCGSXLhQ441uqmklCAO64QWXbsIx BAMGmvEDmjUoECCfYPa5oo41wOkDnC36eKKbLxTYZwUwLrkjCGbIeKYDTeAY54MTnrCBDEYEGAGb P/6IohkfXOmCg3HEaGQYc5wpZB9NUOBjGA2gaAOAcWzIJYg8oDGkDsWgwcCJdJzI44dTNnmGlRAQ oAblbq4o5BRbRqhGBicEGCOcUtCphRBQaMmlHhGaiOWOdu5xNAQq0FGFgQnGIP9jggnigQaaKfB4 4IAm3ujADEqs8AGZRC7RhwgJxJFADwDYWeeXK84RQwgdxuEDCEkyGKGSeoKoZpUspHD+DVZ+oecE XvYRCQxUAxzXMAEGnAeNBzhDE4mIQSg4sQUY3GAPtihAPsjAhDu4QQr9C4EasqMPBICCDs8QAw4U QYdmyKMZEPiAPEbBBk0wQhLqgAYFJkGOGPQgDGBYxzvEQQB6BAMQcNKCEDrwjCgcQA4oeAAtEECL cECjDgmEhg5GAQ8hcAMa8cCCKwBBDW6AgwIT6IMcANEEJtAPA0lYgwgiEQkpbGMbSGBGPWhBCzCw whY8AIUL0gAKEcRhEIN4Bin/oLGIf9BhEyx4ggBuUQk1RMMPY1BAAsgBi2/0YAiOIEMqGlGMVBAA AU3IwRtsoAkWcEME3WDACGSBggm8gXJWTOAouLGKBJoCCKPYBx38cIEK1IECsaCfEPiAgirwYg06 AAQgRjGGPDGBHwJ4gwgMsIIgMIAJ+ljANRjAD0VwgQEsQIIa7DEOHWgCG5ZwRQe0MAwxqM4WzgjB GOLxACfgYhJKwAYBXDGPIBZgHu9IADva0QRG5AEBNDDHFnR5ASf0gg7caEQi7FAHJ9xCB1pIxTgi wAnnyQMJhCCEPCrBByc4jwGDQMY4ZPAAZFRhDCFLWXZGwQEAhOMEQZAHFxzw/4d37EAU0jBHHroB DieMIh8GEMAosOAMWcSCCvMYhCPikINK0CEfAEgFHGbggH59oQEJWAc15KEBLgiFHPMQACOKwYM8 PEMOasDCAyLghwmowRanQAAGLuCNBOxhHeIQxS1aQbk8yIMXdBiEHkCRhjQwIwh1AIcc5MAEu2IB CMvgRxCeUIxnVAEOWmAiGySBDxCsNht63QQ/WvaMechBEjRAhgA6Oo4MXCMedUDDDoYwBFggAQH6 oAUWchCEelTDimvQhivGYQB9qKIedCjGFZLBAi50oxtByIbZ8uANSdQ0F3awkD7uAFgzAKEbd6BF EOxxDTFQAB6kcMII9sEFEf8wIQcgcIA5olCHD9TBBHAAgRJsFoFcdIAcamjGK77gAQI4IhEOSEQG gOA8J7zADNKYwCAUwQtwYOELcghHEJxXhAf04hZ9aIQsQhAObhggDgr4RkeIEYkVQOISLNivC4Kg hjh4jROJhYYGwlEBP/AjCd0wAAtwYIc1JMEPa6iDZaGRDj6IIh1Q8Gc2TMABZExAAM1oRADc4Qo+ 8KELknjFJlxgi3LYohi2hAYgeiAJNnhgGnAIhww+AI0guAAUTxhDJhoRj1foQ5db2AQ0wJGJN9jD HjbYRA4QmIc3kCEcnBBAKoYRAuehABvYcAUD6GGLZ/RiAvBIQjM4wYtuKEH/HIUIxiW64A4Q4EMc kmBFD5SQiQtowRXkmIYX2PEKeQTAEvroNCeq2AwxvIMN1MgD1JwBA0aUIxC1aEI8gFCFJ2ihEQt0 hSz2EYQ1TAEaUMBDFBawAG8swAou2EYQPkCGfVRiBHHlQhVH8I1yUIAa+siHGuThPBkYAGRp4MM0 2jAMRrz2DVvIhBlcIYFkiOEPlqBBAEDQhlSkQhaT0EEUopAOanDXGMaQAspOIINmMKAOW2ACIUIh CiCIQhTFIIMYRvCME+SABTbIwAZSOYN28KAEPshDGuSjijTUgwGSe8MfJtEMaOBiC/KgBQO6kQZa dAMax+ACC2pRC13QwwGO/+BAQeFAhwmswAXFeAAu+EEAJbgjBmMywz9MkA5GNAMca+jGCuphS33U 4gEU0IIPQgGKS8BiB6OohAE0EIIAFEADGLBHMVKeDTj0IgNeQEI1uiGEcSTCHJVYAS8ioAVkpKID 8hABNVzAjGrcHhTUTEIf0KGAO7SyDZJIBBzkwIK99sGFH/CDFhhhxS2AYAPLaIQWsiGKLPrjBOg4 BR2M8XoX6AIMTh1FHMbwhjEgo9r1YEYemGGMbB0AA614QQYSsQBhGGAMGtBHLFYNEJBAH9KAuzDg AP4AG8YBA05AA0ihEvZhEHoBGorAB0ahaapMmkihCyzh5J5hGOAACULh4P9C4B2moQag4Q14QA3M AQSwgQ9ASRLigRSEYBhEQRZaIA0QaALkYBiewRloYAc0YQyCIByYgRs0wWOeATAm4R2+AAPq4Rre AAfaIBFyAcm4QRUQ4AmqAQqrIQ4sYQZCIBiyoRueQA94oBLiYHcOYARGgQJE6mk0gAIZABkaoQ8q gR54bR66wBn2AQ7mIQjIzAcMgBdGoBbeQRbAofBWwQD6IA9WgRNUEBEe4BnG4R+AoBEYoQSe4QAM IBzIAAXSoQbEwRc8QBA0ABiAgQQKABneoQryIWQKsBqqIRdAgRlaQWh2qxoKwAxKIQ2QQOrCYQx6 AQ6K4QA6gAcAoQDOYQz/6iACmmENWsF56sEFyCARQEASyMEd3EEUUsEJbCAWKgFxJKENUMAP0kEU ZkAUsIAOeOAK8gEFqMAZbGAUTGEcAGEYxqHfXGEQbkEIhmAG5vALbiABYEEOJqEL3qAaCMEZnMEF GEATNCEE9MEFcG8F4sECDEED5uAM8CUXRIABKEAI6EAekGEUOqALBkEO8LEANqEJ3kEU1CALsiAN MijsYuELeiERnKEXwEHQ6GES+IHazCEVngEF/GYegqEeCKEF2AEfdsAVpOEWfEAOVE8TTCFzoGEF BEEQYkACCkAIRqAJusAHNiEEAMHMlgEaaDEcmKAW5EATyO7IuOnEcuEW/8qMATjGAAiBBYqLBRxp Ah4gCgKnZsQAGpDGAfQgFj6IG/KgDnCAFd6gBPpqBuSAo4ZBGqJgHKJAEfCBAL6AHuhBH6iBDJCh XlIhG1zABZwHA9aAD6zBA1AAEOggB/wgFxCAB+hgBCSgFIiAFuqhGzAAAwTgGVSBpzYhF8jgCwyH BcaABS6BFvqAAkxhAp7AEeghYujAB4AgCnKAa7AgHvJgDMBAEyxBEoqBHqhh95DgEtrhHL5AEeQh FuRAAjugCqrgULahEO4hGPagqZ5gCVThHBKBD+aAJkGhHl5hDCrBFkIAC3ggjxDABvJhGOghDvag FLZBClZACoyhRy7hHP/2oT57ATuvQAjqoBliYQn2QQxcZhHt4ACeIR2wgAVssgNcoW2EgAIoYBjk wBY0YRrrAB7AQQT0YRnBIBjmoB30gQlYoAD2ARRAgSZ/4QmYgQl6gRzEoRQashyygBv0gR5AgRAK 4B1AgBvQEhB4wBGqYByeYAW4AQkgQQpcYAWkNBJYQA/0gBpEIBe6ASTz4DHDjgz0wBFCgA7SIAhA qwOcoQ1kQQSCIA30QWEKMAdkIQwIwAHmARmEwAnu8QsiSxUuIRYIoQmeQRNOIQBgASzgYBr2yAH0 QQ8cIA32YTggIRLU4BIQ4B68wPQAwAswSxZcYRgMABSCAMkkqzQLwBz/CkAfKkEOqqAAciECNCDs MCAI+FQETmANcIETGKEIoGEV3oADAkwGuGsfvKAdVqAdCuAZAAEH5sEZcoEOUEAPpEAfILVaq2EL nGDwjgEDUiYIqgAEJEAfxmBXxfAXpEAKngEH5AAA8IEexqAAOmEdyiFT9eAXEIAxsQMUBhQAOuAL kIAJyMAOWOAKWCAfQoBT0+ASgiEYSqEd+oAT/KARpgAeNAEAUGgf2CARDqAE9GAJ8mEc/GALDEAO voAF5EEHnEEKtOMcNlELdIATNgEQwCAWhsEZgiEcwiERpqEJnmAfAAAOruAUfsAYlsAOSkZS5YiD IKGOVMEFkGAJ7iAS/2SREBDGFsYAC3TAB2JhH9JBHorhCwghD7gWybYgUEcAGbSgCr4gFrKAF7J0 GoDgAxjhALRgFARzAooBalMQEHRhHwgBTaCUGsZgEOhhBCaLCXzADiIPAVRhBUIgBMgOAYhBF8rg B8DgCoIxFIaBFdCUCtpBCtrhCwpABEhhAsCuCcQgG3jgBLggFqpCFUQwISABFMiuG6hhGqFhC3jA UjgJRqBhDOKgEhQBEOpBAk5BBLbAB56hCXLBFR0gWpEgGRSgFIwhEqYOZZo0FBJBAbYBEk4hGMBA hABBBODAEoRIEx7XFdqAr1QgC0ChCWyBAKgADm5QHISQC+KgbNDLkf9ihBpogU+ZAAlWAANWARQo 5QRwIRHawBnigAyyMBwmgB4uAQlCQHXTQB6YZg1IIQ5mQBLkAGh0TxPuoU5XAAGWgAmchwVKgQSW wA1UgBiOUx+2gQ12wEgLAAeGoQAQYB9CQQ7k7hICYUuvAwFCgAea4Ar0SA+QwaUAoFCRAAmkCAw6 oADSsB7qIRfOwThAQQ1C4R6+QAD4AQPqwBzcoQ32IRUyq5YSqIGcART0oRvqQRUiwQX0GBDggBYM wYqKoAScYQ5UoAkiYAuygQocQQ6AUw3mASy94BKoYRj4gBH0IA4EgBzeQQCggQt292SqMRTkhweo gAiWACOe8x4KoAD/uOFkRDDhNIAW6CAEnqEE8uAEqEEVwKBPc2ETBrO3ZOAVuoEWKiEReKAa/EAC iKEix65c7Mx5REAEoIETIiELVGTo5rAOulAANvMZFMEA6oEa0uAWHqAPGGAUEocVTqAb4giT77UY mmAQvqAeTsA5n0AWuoALkBgUNAAX5CEYaMCEqUEGRAAeY2EQxkEacBkQxmEGJIAHLGEWtgEDfIAd EgEjFMANiCAZ5tKKcsEZuuAneeEEJoAJKqHNSgAWOyAfRkAI0uEApk4EWAEMHKEL5kEMHMF0NSEf ZgQS9OEKegEQ9mEuVIEa1IoY2iFlbk4VsqAeXtMUeIYW3lkOEqEH/wphCW7BFFjgC2ygCZaAGgJE EAIhFEQAyn4QAMCAHqjgDrqBFJpBAADhCYJABGLhF8gac4KAC2ihAGLgFDKVC8ChG/xzCVbAEZzh C8jgBMTAgTtgGGQhFaRBA8QuDaghHESAEJBABEBhG2RkBaghFHLhAUCAFQihGABHDVYgUSO1GAjg FGiBF7jhmSSnGuztB7ZBAwzAEfBhGAhhnqUAfwjBFhxgBGyRNEGBGpZgDnwTEnInmmGhB8pBGuzh AXiAHuQgGSaVFrigHaJYF2Jhu4pQA0Ayj5jgFs6hAGghCwnhHhKhrvahGxhhEiigCeQgG64A8aZx gOxgB/yKu9xP9/+ulQFowQXcQA3UgBC4oS/bYRtUYUxb4BfcbwLEchPuYAW4AAWk4bNpYQzsIA7y YVu7wUO3oQXAWA5CgRB2hQBiMgSmzpZO5shyQB6QKgco4CehgReq4QSYCxpaAYGchxP4gRESqxU0 4BZWih8mIAemsQhqSQYYQB624ME6Lw9a4cpz4BVeoQT6oBkKOYEYoATqz3VwQcwZ4MlboQ7yoBpe gRFkQMS2YIAKHba6IQO84Rq8wQIqwAbagBV0oAtCThI44BUi4BNQwAHugBAKAQTwIAVSoB/8wQIo QBQogQMSQR3qQAeAgBIoQQumAAgOYQomYQPMABDUgB2y4QAQoQL/wKEL/oASZAEEpmoJhMAH0gHC DyEd8IAPNsAEuMCx9aAGTGESgKANyoEP/sAMYNAURiAZCpwPvGEczCADlGAB8AAbgIARnOATMqEE 1sAPKsAJVOEC+mHTQUAUhsEUKiAFMAHhMwEbQOAaXiAhsSEDoMACLiAj/wERvIESfCAeZMERNnHF DmAZoADUgEAb0sEH1KEEhIEDqv0QtIEPqoAMKEAHnkG24CAJxGAeOsAeynHWF6ECaqARmkAUNoAF 0mED/iATFiGwlAAR8EAH4CEaoiEJJiAJ0oEKNsEJUgERJGEDlMAEoEHVP4EHdqANtMEKKAER0oEC EGEefKARREEH/x5AERbhCQpAAMjgAdThEA6gCw7BCSwgGsDBAtRhBPhgEihBEv4ADswBC7RgHB7g F05BHKZBHJagA+ZhAY5AEJ6hHxZBDLwAB0yBDsbgEEQgE7OhHvrhE7yhDUbhEJQB4TEhCcjA6jMA Gw4gGoQBG4ILGybBEFIgGj5BHSygDi4gA/AA0ZDFCpYhBeLhECzgDVKBB1ZAHfjAHPggE6xACF7g D3yAEDZhFLRhAUxABsSAA9QhCsjVAiyAC7aBmFOWHgrBDuxADGoAEy4ADiSAFRwABV4MGwCCUg1h 2Bb8qwAOiK8y8qZYkTVFHQdH5hiEA5XBlbM/LzBhincBHqZ+6v9YbEH0pxEdC8oYpUolpUUBF4LK iJjEh8IbHh1Y6eHACJEPIZmUCKPgcNSbCTlGOZIQ7Bw2bKb6jZJlIhoFSkrIWVKywUQbUeQWHCqa aZCkQ8qSTDnkD5MIbloa8dEWrVsUHVpMYXJiDw+iRab+NduCydSCRhOwvPgjoQu5LpK+dFBkIkMX YVDauMpgYw0mE9qGpXrGhxIfHs9chekA6JYdNVgs/NtgCUC6fhaE/cHWpk0iSV2UXPMxA04LTQYW 9VsUjXcmbNeamJjyr592RCaWbci0SJ2WCdNVaIBWAxslGtOQvcKi402YAe/MNFmj7c8GFAWdyIPE SxI1/PGOHFD/aLNMKpbA4gUJcbDABDcHjEPBPzqMkop6FVQwjAOa2ABHIli80s0kIEhTST7pVKBd P5gskkoDAShxCCbRRdePMuM8kAQiL3CQyAy9RJEOLQ9IksAQmTixgAn9/PPJFI2M00gmG8wBhBCM YAKPOlOkQAoW87gChCmSiOHECem848w2bhDBDjl6fCGLLDggIowrUKQjTBdZpqOONxtQg0gX9nAB iBAXYHLBJ9DU8Y8jkFxQgxPQXIqJBeAwAA0QbbzzThcPmPJCNn/AgswfJqBnAiKmXLCMNkBM0og2 5rDiSD7/fJACJmtQY4cr2FjCRhuWyEJAL1NI4gwtlRBzwxFh/ygABzJ9MHILI6bMugEU//iggygZ ZOMNHvYs08gk81xjwrnL/GaFEt5ksEAmiGQzTA3LLIMIIpnsYMYLg/wBQBqhcFRHChG8YM81f1Di zR9/iGFOGJRMQok/aIzihSjq2NPGODng0MYgD5RggSk+KIJAB1j4ce8eMGQjxARk5FBByogIAA4j 4yzjgAhOaOPtAthkIPE8flWhgh/Q6EDBc05EYIgh8FxtdQpA/KGEEgAAcgQIOPjB6DJ11GDBBRTk M0wG7+QzQheuAhIPIxW8oYZvyFBgjxMSqTHKPs80gswLSpgxhSFTYCMKIW9Uws40lrQxTBRCRAFO Cd684MQnyv/4swgFolixDDgnbIMKNojUAU8SScBjNeyGfFA17S8sMEEUNtyyzAWf4VHBIYdoM0kH iVTRBxd9UMCXKSUIcIsiqTRRCQNTCOOXIoDQQUYJOnQgBxwggOCFHIiAU8EFF/yzti00uOLKDBu0 YQIF0NmISQoWaLMBH5L8MQ89ZCUF4CDF1bAmO6wZIhq3mAcf0mGFDTDCCm2ghBkYV4UmxGNHAlCE NiihhUKZgwmRMJwQ1BCLCPyDD3yZRyJGsIkxNCIRp7jDE7ggADEIQxaNiIL9luENSkThFk0Qgyuc EA38ecRG/5iCNojDDlPEox/+8EMKDnjA2FXNEGiggxYygAL/UQBBG9MghwRsMIFXmKMDE2CEFuRg imjYgxKSgIMAHpAOIIgBAI9ARh0q8AIHgIEVcNiHFsygBBSE4g6E4II6+PAHM6REB6awwCEINApF CCESzViiJ/NngQxIQhvCmEIGKPEGK2JRgR/A2hucIAxKXMMK3kCk0dzxgmvMwAp4yEDA8HCNqeiA A3fJwCHIAKoFmAIeiiBEP1LxDklk4wVaAAIQfECBUTQBfXSIgw3iMYZR6EEBoqBEB54RCfS5yCNJ TIEhlmEOZJhhAwZ4Qw5uocoEVk12aBDGMqCBoAu8wBGv8McFcOKDTbDgH9qQxTCgIAQugCMDNUhF JiZRjCa0/6MFlwgFIj7wBkfEgQdEkMQCrnEBHbCLAnxwBQ74AQ4sTCCJKHBH1wLwhQesgAnSQESO KuCPFPTDBCj4hSsokYlPYGIKeKBDUOFxRXjQrmp1QIY9oGGIT/ChC84gBC36EA8+iOEEtxgFH8bU iFtkAxs6gMYiMtGBEHBgGEsAAxeCUYgnxAIYQ2iHG/RRDGxUARAdSMU/xsGOeUxiGfwQABoM+oB3 JIAGPChAJJBQAWUgYhlT0MEy/uGNBShDqBfAgxLSkYp52EBfyuCVSAzhBGdgwUX++IQdNKFJJfwB BYlIhTCiYAI+SAAVlnCFIkxhiDoswwz42EEtpFCMYSCjB//IoMMPfrCNLGThF89gRyKGkYQLPGAf BbABDsjgh0VUIBop8AcAOiGBUtSCFC76Bx7wcIhPqCMKVkyBf6OhDB94YBoE+MA/sDFPDiBjHC/w CiXMEY9ofGCq8PhEL0CQiHmMQhpWkIc9TNCFEWgBD5nQwSRKAAgFIEAfQHjHKUChDiV8owfxU4Au ELCNHbSBD00sBiTy8YAJiIEc3+ABe/3RBXcE4BROGEkSPZICdVghCb3ChCH+8YJG7AAb9vAHNJYr jEn4QRtKWEAqGvGPqK7yAuYAhCSw8I8ukEsYQBAAHjYADiukoAQdSAY9HOGKLhQDAVxwAgvQ4YA3 gGEbCmj/ARtsMYFPLMAHjLADGJIxB1gEQAIXEOok2oANGi3ik5hQxwam8IH8XfF6kzgEJRpRahv4 gAVyoEQXEqEJPyRhixQ2RBLg8AcdbKEEb8CDN/gwEHtEYED0osRvpuENQS3AG7OMdgY2QC8zBDED j/nHBdJx0TDQowkIoIM6/mECPFDGnqSIxpOX6g1hVMAQHvnAu+T1LmH4YBwMcMIiPsC6fkBDHRkA B4VhdwsccMAVqXjDLcbgh0ZIQhrNAEcK4hEMZ2iiEqpoQRhasA9SPEMWUZgAN36BDHEg4YTbKAUX rGiBTHRh5tIAQiZsoA4olPIaC4hAP/yQXhdVIBOZ4IEb//7xjwUYbQfTDLQOYJe/fR4QE4dAhA4i UIcFCgPD4WsED64Qpi7Q4wHC8AUKGrCD35AjH0gIhSwckQlJJAIfw5iACIbxjrpXAR8tuIUyKiCH ZYhBDjiIwiQAUIwaUEATWIhCI14BClU4wQ9XwIEwMqANYzshBVMAAgf+0IUMYEPPvVrlKjHxjwxY QQdHtQEZrCCKXvDhHZpoBFIroIlxxAM5kjAHN4YhCRSUgAm0OIAzqLAHIjyhGekwAwrIcAA6YOEQ F/BBGMQhBg5cAwW9hIMDKIGMYhQgCU84hwksgAUc/MPdz0kFCJrQhT/sRT81qAOUo6pm/xrCAgvI gBZC0P8NBnBmgLAB73ACm0AGDAABrpAAcnABb/cO5PAZ8RAFB8APlbAEJ9AHYXAEsbAI8QQENRAP /GAKGcAHUyAKstAFrlAFwvACJtAutCIGPpAFxqAF2qAIVOZJOSIAgdYBYoAJjXAI3oAN/zBa+ZdF BiUP3SACSSADZKAFcGAJ9EAN2WIOWIAJ5+ALKiAO5fALWCALwPANd9ALtsAFJLAH6eAPI3APPPAK a4AHXMYAExAHhVAKYIADqQAHcPAMUIAH2pAJQEBBYvUN5KALLsAISYAJaMBOFaAKbeANvGQGCwAF owAPQDAPA3RF/nVFygBP82AG+dAMzeAA8bYBYFAJI1D/CU0AAsKACeDwC79wCaLQBnAgB+hAAtxw B7rgBroAAo3wAQIwAfGQAxQQD81gANzADU9wCQ8CBlewBKFwC4kSBYjwFsKTDZAgBRMgDAuwDL3y ZFEGBygABKADMwtgBWTwD1EwBRfgDy2yCLfxB5LADh2gCjzAAFwwARXVAe8gChTgBEAwDukABa+Q DXxQCQigCtmgB3egB+SwDqrwA4UQBUZ0BUwADv7gBK+QRhx5BQpABWcgAfiwADVgD0RyCJ2HDGJw CC8ABfvQAfbACFW2ROowCfGwQNrxCRcgBIBAAdfQNdrgB+DgB/zAAaIQetoQD8RGARfAD9RgA5Qg Blow/wmT4AP6cgF+IADl9QbxYA9wgADUQA36kAzEAAuJEAdu0ALk4Al2MA5uyAUJuQ0wEAA9sA9X gEfaIEaZMAVYYAOZ0Agv8AAOIwydhD8DJwsBcAj05hGL4DkiMAbDMAnqgH4AQAEfIGWfkDUe4QcH wAN3kAW1JwZ8gAKxBAepUAKIEAUPQAZcwA/hIQnlwAeWQAP7EA9OsA3BIA4twA60hwmM4AUAkAMl UAGOGQ+3UAmKwAFdoA3Z4AXI0Gq70AZVkA3iNAYQ8AFFoQQNUAz/4ElCFQ0i4GzmUAH/YAOT8AzP MJOrlALKwA/CEgvxlgmxB1HF4I9kAAZUwAEH8AQ8cP8LaAAPE7AEZIAABkAGhaAL+mAAqkAGSHQC kVMFjRIP2SALcAAfI/AEV9ALvaAFPoAIlfAEBqAG9CAMNeAi8FABwgALCCISNrIIawAOD1ALBMAH mOMNlnAETKBqquZfnzABCvALspABD6ANPFAMZuAKq7NAE/AE+cAOBPALRNAODmAPbcEPT9ACheAG TFAJ7ZAPSVABPBAM5XAEqBALDyAGDzAFWYYQz1AFIzA4mYAEsSALZxAIlhBq3jAS8RACWDAFy6AO i+AHBjACUeNujYkHfPAFSLAoUJY/TwIL7uAMwVEAk2ABiyAEjbA+oAYCSwAOi/AAdkAGoaAAnaAG fuAtBGzQAOWwDe1AByqgCxXACFewDSCQAMAQBu/ADr6ABaSDCeNlB3YgAW3QAAEBADs= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/content/vol103/issue20/images/small/zpq0190621720006.gif R0lGODdhyACTAOcAAOTk4+Pi4q2tra2vQ//uWPv06d/e3vX12dnY2J+fn9LS0dHQ0P/0hs/OzpmZ mZeXl/ffx8vKypWVlf///YBPJJOTk/79/LvVWvHz2I+Pj8PCwtqRTsiOWsDAv/uKaMd2LoODg5LD Lre2trW0tH9/f7OysrGwsK+urnd3d/2ym6ysq4y6HquqqnV1dbxnGamoqFdOR3FxcaampaWkpPqr jqOiop6enfuihZuamt2eZNdwMMPYYdrb25GQkL5wK//ziIeGhszNzYWEhLq5uOG6mf7+/vz8/KXM Q/r6+p7JRn18fPj4+JdZIvXranl4ePT09P3tXuepgfLy8vuEYO7u7uzs7G9ubmdmZuLi4q7QUuDg 4P382Nra2r7Lmv/wcNbW1vqPb9XU1dDQ0N/g4vuulO5wQs6DQPr5+cTExP7488LCwr6+vkFAQLy8 vJfHNLq6uu7t7bi4uKaxL+rp6eazjPj5+rKysufn5unz1Obl5eTj4//1g829suDf3/ZbL93d3Nzb 2/7++aCgoOCxifK7nv/zhvqFZM7NzezLr//+/cjHx5KSkv/7yMbFxf/0k+jEoaKqJ/vsZMC/v4qK ir69vYiIiM/iiI5UIZ6ejby7u5euHMrLzPuUdba1tYCAgOK3kbSzs+3015K7JNDT1bCvr3p6evX2 9q6traqpqf/tTainp6enpqSjo+7YxKKhoWxsbPl5Vf/sWt6YW8rIyF5eXo6NjcPCwf728YyLi9DQ 0by6uoaFhf///8jIyYKBgf39/f/2n8bGx359ffn5+Xx7e/r08PPz86yqqu/v79nc4O3t7dXY3P78 9/769+1rO2ppaeXl5eHh4WRjY9/f34BTLOW8md7d3oRSJv/8+//rRdfX1/75xdTT1FhXV9PT08t+ Oom8INiMSv/uUv38/Pv6+sPDw/f29sHBwY+9H7+/v87P0cl5MfHw8Lu7u/Dw73Rycrm5uffq4uvq 6uno6Nt6PNLV2AABBwAAPgAAGAAAAABkTABATAAGAgAAMAAC6AAgACwAAAAAyACTAEAI/wB5CRxI cNOhJ68W8WKBYgnBhxAjSpxIsaLFixgzatzIsWPHYaw8ihxJsqTJkxUNlCj5ZBXKlzBjykQJ6I1F eAj0tJgkzxMKeQPjcXj0iIjRo0iTEvm09JNTp4MGOeXgo9hMkmBgXd2akVuwklRcwkT04RZXj5y0 nl0rcVMjjMoe9OKlYuXAKgJiPvrAjO1GD1P8Ch4YYZPAXrgklKtwokjGOaQGY1v3abDlywI7KBB4 rgcOGw9EaLwjWnCzD9Uwq/bbToxAc1RqeDM2DGIvFCyUEctgZGC0ToPTfHi0ujjXNTwGkmsDyk4u jdPWDC7wARHbNhzHseC1qtEwCYti4P+aw0seLl9fImJ5yOXPRSqKeKWzUZuiGikS30R7DaTGEiVh RARANOTYgAZBX5QzWDw+tLIWEnEIFA8EFFZoYYVm8TKHFSOY84AwCZzgCy/kXAHIIq4AMMMdXMiQ ywlxiEGKPN0goIhNDfQwokDziBCBKbNEwI4xbMBzkRrmSMTCPCUtcKBxBA3yjQUmmWMTL15ko+WW XG65zUAgRDONNJ4B4csqxEyCgzQ2eJLBCZOQYEMw0GwyiRIZxFCBBLTgwMJ8wjiAwxWv1CJMJTEM xMI7MXSAixLnJEALKgO141BELFBRUhARQBmlGSeZco5AeFhi6qmonlqAQCrcgUstvPT/gIAS3Ajj yRczPJCBCD2AcAcIMSiDiyA2nPNOBbws0o0EMWRwhzADqRAHCwn4EgM8wijixKUSdYCEku5ctMQV LaiAQAwJENRIEJ5OZAYd7carJDslBdOAvBB9Uxm+/PLygjEbsWODNgSpwU2/AgWiL8L4CvIEwxBH LPHEFFc8mAjPkFCKFu60UEkLwLGhhzIooGCDQPCUZkMjOPwiDCgatOCEAeYORIkVpUySZCY2tRHD O4q444QVowq0CAI48EIJGk7MY0MLIBhDihXEwLFLAjiwI8SxHvLSQQcMK9DAG9Io8YcNpdwxkBEn W+y2YNDYUdISMrxt91rTRFgRAlXw/4KKgmuAQtAWOzRh+OGINxGJ4pE07vjjjUMRieSQV2455JJD AUUsBMSyeSyeb6456KSDTsDpo3dO+uiha+6666dzfvrsp4sjDgG234477rn37rvtqfQefCrEF2/8 8cgnn80eJSEjSExkWYVvWndfJMZXJCmjgl4fpMEvGIFVX1EEc/FiikDkePOtYwOd08IDd5TiycMC KWOCZevAKz5bEySCzf8AZAY2mkHANBjQgHy4F4naUIpnvAIIrsHIPARnmnWkZn/8aoM3CAIKLTjh fg+RhwTU8IsEjIAgWACOaYaDQX7BIz0DUQAupFG3jEyjNH65RXXYAg95VKEK8gjiPP+GOIcizkEe cxjiPKDBRADowYl6wAIWokHFaVjxitbogxWtYY0/eNGLPODBF7voRUBwAQFoTKMaEaCNL7jRjdpo IyoAFpF0aGEg03hCEFjxC43wQA0L8oF1zmKEK21kGC8oAhVOIJB29JEXyFgEEKIRgF2A4gt/4AYP atAJefDAFybQRgTA84W6/UIEUjDSQNwhGhwQg0kUKQf9IGICAGREGw2ABjHaJpAvPKlddPgGNkyy BBxupQbkuYg2vkWScyQpIiroG0kagL12SYl9JDFHOmRShd7wYpaCkUR9IHIKel3EUdGQwiLiM5BZ sCteUQCVSYxRtBYOJB3MhIgMwkX/Eg28s1+J+Ib+7LkVAeCHJGg4GMIssDCCHvOgGVHDK5I2EOZA Y4pUjIYUsfBEPehBoxjVwjQySkUsAOAFrNDDNMj4h2loAaRS1OgVv/gHLlpjpDY4xR+SwdOeJmMM QA3qGHyajGUY9ajJWAQ8ilqPpjr1qFA1aj2W4dRRWHUU9fBEMOqBVauq46tgvapTq6qOTZh1E8Eo BRo2oY4guNWsvehFMIIR115swq5wrWswynGONfiiDiRRRRxcgZ2S4AIAJMhDKfjZESMAAQdIIIY8 SuHNjigDASIoBS7usCOPOKAbbKhBBf4AhJEAggozEAYqFtCDkYCAG4JQwguiAQO3/2XABkuYRTfI oQ0bNIAdybnDHIKQgAAMRArd6IYRtMCGU7BBAUt4QYT0IAkYdgMQvEABIBTBhpOhAA0jIAEqJsEN aZBDILTgwhdKAJzN5EEQ7GIHKzQwDzYE42BhsAEXeBGGEYACm/hCwglmUJ5SrGIV7qiEQPQgiFrI QAYzmAErBOGKBCSgBq5wRQ0wjGFWsGIGMjjwKlSxigh/OMKqYIEAVCAAE7iYFKQ4gQBOcAoBCIAU LrZDCewAiubwGBQm4LEdXJxjO9hhBJ0QgQji8AZ4vKEdUIbyk6Gcjg6soQPnyLIaysFlLm+5y2gI cyPmGtcIBKEBYliAGHKRCwV4w/8b3OBGGMLwhThqAwFh9OJNtfBSKXq0o1gIwBOhcYd5BPGHykh0 oqnAaGUwGhkmIYcrHErpjUTjhCQZRg0rzemKaMGYHjEHgTtNaon0QZUjMUZISs1qgiyjHRUxRwV6 0QNoCEAa51AARbWBCTn4+tcDCLYchD2AYRd72L4+9q+BXWxIOPvZv4bEsuXw7Go7WxPYzrYmIKHt bnv725oQhbjHLe4QhIDc4kaHutfN7na3ewUrQAe8VwAOea8bHPjGNzrAQe98+/vfAA84vleQBbCk ayxV+Z5aOC2Gt5AEGTWAXsKnt/BKB0FBJKHCC7jnvemFj9NoLYkytgOTvXRcXuD/I3UEOiWQWQjh FTGQwDQeMoNuvOMB18sLf3vAS5Q8wgXr+IbQh070QVrGA36AxRSWzvSmG+LpHjAEYAwxBal74OpX B4PWwZB1MHDi62C/gdjHTvax0+DsZxc72snAdjLQgAwpiLvc5x73HPBBIBXAQQAk8AAgPPMi8oiM YCazr1YPphwR1IIr7ABgjMyBgn5phgUNbxlKbIYk89Bb5FFD+cG0ZiAIEMIuVgGrjEAD1GdhBgs7 75c2KFQgSzABDEDwkF90AxeVwEU0QIHpXqh2MKchDuvZQon9CoQdtWjD3zFiDdRzRYdGHz5XKGEN PCrBFMZYvkWsYUi2QJ8tkqh0/znMCRFK7Och5nBCZS3yB+kIpgCCXEsRYM2LcLjg/vjPP/4HIZAZ TGIGOEACcxEDl/IKjyQM5eALQFALk2ADvlALriAMlCAMEpAB3SAEzzQO0qACvqACTlAB5AAIPRAB qmAMuFARakBHENEJeiAQbDAPI5ABvGAF54URXOBwfsEgDnIW5KB5BIUG2jcQAgBLFTEOwvAKpzAJ qjYLAqEGQgA2gsEgH7AOVEiFH3CFU5gDJ4EEqnQL8TAhF3IhzTAQnoAAmxBiMuAN0sALw/AKyPAC JNANNrAILcANkzAJpUALDsAKIDBDEuALEiAGnjAQEvAFoQEEQCADtAADxHAkQf/IKkBBEgqgAfIi JcM0Nz6IEUXAArjQAx1AMLygQAQhD8b3EMgQQQPBBY9IEKA4EaagDAMhCasYTSXRABhnTd+QCFVC CR6xCnNwB3EwDZ2gAu1gBTagCCgAAydQDqQQA8OwC1aQHoAwA6hQBTNwDjFwBUHwDlewBrhgBZ0A BMIQARVwBT0QDLb0BmLQCQdTBEXwBCKwcSjDLQ8hAIwlEodQPtYkTyVhDoDEC4FQAAJ5QARpQH0h EEDgAA+wCV/ABtCAA5UgDGtAAiigNmGQAVLQAEDBDSQQBsNgBOTADhtUBekhBZmgYALxC9BgS+6A DMOwCL5AexRxDvn0EKRAfiL/URjyEk8n8QS3uBHIcD6jKBDuME6/0Ed9VAXn4w7hQg5qYwotOAzQ QA4N0DdG8AtGgE1FwAPrFxE0KRGogJMVYQOuIATDUAEBwgvtoASHUIkuMIVVGH0aYQQi0Abt4GRr cJfwAGVtsAbpQAmAaZdvMGWAmQ7p4JdVtgaUYJdRxpftMJhNBg9xsJdtUJnt0AaDGQdMdplXdg6S cA4dAJiZoJnwQJl9SQlyIxEvIJYdcQ7/xC8BNVDStxEsAFEicQ6GgTCxOZsdoQIqKBKNIIqw2VC8 qREzYJsegQZp2S/YQJzFiRGu8JsXUQq8kAEtKB+egF0MYwbrEA7e+Z3gGZ7i/zme5CmeGwCe51me 4bAB7Nme7tmeshCf8jmf9CmfOXCf+Jmf+rmfZhAPz/mfMwEPPQAElzcS7cAG7jAJMiAMNbkRcyAB oPF/MukR8lABSjCRONBaBgoD8+AEPbBpHaEA3YAKBoACQtB9HNEOJOALQYACJKBzHtF4JtGgHfEL 5tBH9Bij9bGKHgFOHiEF34IE0tkRQckL5gCLb/MLNbgVSCCUABoxiyCP0qAAM9ADMKAFxEAJ7wAA MqN50kACz9ACM3gG78BcuOChk8CEvFAEVRANLNANX1EDJ0MMDiABQPAOCMALz3BHvCANipAoIOYJ KsAGGVAoiWIExvAOd9ACtf+QFziAA+/gNxH3pCbRCZriKdagpgQ1DTDAApsQB0IgA7vACiBKqZ1n BzOABbRwDmKAC+WgELzwC8pQC0/wBMZgDFIgBezADu7Aq0yJDMAarIw2rMMKB4rmaI1WBYkGREU0 RHdwB4QGrSv5Zxg1DV/EA1xwRgiQrdt6RnfGRm40Z2/GZmKAZrnQAOjaAG4VBHelCIoQZuWgBlmm ZWqwZfKaZV+jmIz5mE0WB0qmZJNZmqWpZP5lAjEmACyACqggYgf2AizAYjNmYwiLCi/wAjJQA4KQ ALhQWCNBDgdnqtWjByo0EkgwqSB7N1qAaSOhaSdbPQagsiIxDGLRsm/TB5n/2BF0Q7N2Yw03yxGm MGo6azEGgKIdYQyUErQWwwMcKxJb0AQM8LRQG7VSO7VUywCFULWFkLVau7Vcy7VW27VgG7ZiO7aF 8ANme7Y/4Ahp6whs27ZtCwxwCwxu6whxW7d2e7d4C7fbsLd827d+uw2PIJcQwQ1sMAt28Cgs4Am7 sE2kAg7m9riQ6waSO7mUW7mWe7mYO7lJsLmb6wacK7lHELqiO7qkW7qmmwVZcASou7qs27qu+7oX ELuyO7u0ewE7sAO2G7u3u7u827u++7u+ewGWYBE4oAgOEAEPoAQqIAKjZgqIoAPQG73SO73UqwP0 UL3WSw9wR3fcK3dw971t/+d2aLd24zu+4ct2cTe+Y6d0WyCQ7vu+BxC/8ju/8osBB2C/9Xu/GLC/ /Nu//RsKocC/ADzABAzAeHDAeBAKCLzADJzAXXB3mjgQAIYMH4sSiOADq4IvWUFquYCDIkHB0PMB 0oNyFUdp19M8q/YSFzzC8UI9nXYIHuwRyAC0FizC/OLCIPeTHkEFpWoSZJEh8oLDlRYB1SQSI8dx 3/NxlbYJ7DQSR1xy3ZPEKqePRrw9UDyG+AIYKsdyFtEDEvAOJpABQMDF7CB4L7EXtwBAagxAqqHF nWZWAuEAvqUMVVAOPbAeA4ECPOAJldAOMqA3SxAGJPcSBdAUUBEViOwC/P93GRAAdpywdVv3yJCs dVhXyVj3dEuHyU0HC5zcyZ78yaDcyWUwyqRcys5QBs6Qyqqcyn5AAwIBadVpp+OkHBIReJJBGUgr EmjwT94gAQ4ADzRKEfIAQpGHy7ncERrwHLzQDQKwC5uBAI8EeHZRzBd0zBuRDhvECw9gB3NgClKQ CzgwcxcxQcDHeda8ERr0EOQQzRLkfFshedV8zhjRDspsDWoQZmoAQxgBjOUcz/JsEfRMEKllMhqR Bz37zqv3zxfxeQIRDf1RA56wpBYBAKjGFqonfAptEW/welLgCzZAhAThC4vgJzggBNnMCwAwzWwR fBl9EW+gz0YwA04ABML/GastUAWeMAmUIAEONwwNQMwrndAtPRHFJxAn0AAVUAox0HMW0QfufBXC gdFDLRFtkBwDwQ0SIA2TlhHNNxg6JNVbMTaL2Q6G2Q5+iWVb1ghoEK9qsAZu7daGCddnXWXnUA5o oNZzpQh11Qtmlq5r5mYKkAveoABisGZtJmd09kZtVGdoxAXYiscR0QF8qiEtoAjsfBF9QLTPt0Nr ocMtFAysKRDpcH5GagUx0AJMXRHTsLRrAX+COxOM61DlgJw2Q9rDYAMSQAyNyNXu5xeufR0C0QrV MNzEPdxEcdz+mV3WcAWVEAy4IAW0gMfCoAbeoALz0ANrcAc2MAMd0A1B/yAIXCABwTACLcZ49yQI 08ANItAI5oACMTAPwlADqlAR50DbAhEH18kLS0CRr0DDFsED9cQWDPLaMTEOV1IMX5jgCX4hHRcG bGANoMAGSfIMz0QCI+DcxBAEvuALa4AKgoALFdAAAOILlWADFdANaHBe5lAK8uAL8CABLnEHk8AF k3AOD0DfQyoQdnCd8PAK0UALJK4RXPBLAh5/PFjRxVEEID0SaOCkNpkHAnEFNvAMbvUKGoEAns0V OrgW5IDk0CkMvpALWGACu1ALeGwD/UGjf0DayTQQw4CKEgENkVgRQCgR1o0R5sAGqMACNuAEaiMQ XJDlWzHgBXkLhm7oE/+whXqDdH7Q6I7+6I1OCAMBBAhADrjACrRwBRLAC2fgBLxQBS1wBTHwCq/Q A0qgkLTwCp4gDVktDeIIBIMoEDrSAmrgC9kCBFeQCRfhTErS5hShDNIAA88gAUFQCXlqpFtmGYjw CMXd7OEgTDN60BYxAvKwCXoQASgAApTIC7sgDM9NCsIgAiggDasQVxIgDGLgAKCAC7sQ3q8gAKAQ LiKABaAw57wAD1Q8EUhi5/buEd4g6KphicT01NWTDqvIAv3eEbkA8Jgh8HOjSlvACBI/8RQv8VsQ CA0tDSMQAc9gAlLQC+5QA1xgBCegAWsABPMwDFigAHbwLbngC9DQCV//YARtQOXu8ASmYA3tQA6B jtKrAC0CYQpnNgzawA19QwvPIxCUsIoCAAe1GMPGISVU0o/0VwAVf/USj/ECUQp/gAAPoAAZQAwx 8AS7IA1/UAkS4AqTQAt2IAFUwAI9IAJAMAlzIARWoAcg0AM1QApOIAFnsAvdsAgkgAsdOhCroAgv IAB38gLdAANrKBBvkKOKAssj0QBQXxxSoov92NuRJh8xIAzmUAQgEEESTRBI4BhG4E1JUgRCeT7a cKkWQQmzTBAncI8e0QD5HvXfIKMdYQ4BnhHm0An/OAdIgATZzQsRYNVL4OufHsxDORFGEAQ8KhDi JBE3uSm5j/n8mE1F/5MFogC54P+4O/gGVvAAVNAT0eAKtOChWqACHbIAiyAEwlAKLwACzKwKm2AD QuALMtACEyUEABHjHS+Cca7E6LDLSaMez5QQhBiR4DkkEiGycGdR40aIQSJwBBlSZMhBZkaONKXh pMQXxIQp4jUDGiknPcJYUfKEFwJBOOY4GOGEVpAYz15UasHKE4g3k6xMCjKPlwg1dhqZk7Jkka9J v0B2qKiRBbuVHGcFKZtWLcEoJtdaNHbu7Vy6ZdeEtfgio0hyNtoIk6DCyV5eEdDWRSyx7S3GjOdK yVSkyC/JlRNfftsGr8RVhENK8GROiDZhAAgaG9EA8+V4RFx/+uRj0P9q2iAr35b8S7eRX0Z4797t 2wg5ckiQDEM+DOQLsieLEHweUc2m2qsTfaNTXfv2lSqkIFZzmDvd69nHn0dPkMX3uuU+pl9bBDt8 +toFGEMcTHz9k+X5/7+MBfzqCkY1AEe67pMDF3xrFfboQiMXBkNKcEILT2LlwbnQ4ObCjSz4RkEP R9RIkAHpKqdDEiPCJsQVXyTIFZ3KykCQFpaAKJgwYCSoxU8SwSZIIYfEJhEjj0QSyQmUNHICJ590 kiAooeRlgiqjHHEGc9IiARphqiBoDhlqGcEEUk5gQQBSSDHBjhLsMCFOE05gs8027QClkzjmBMWO EwQQ4IQ4R+ikExH/DhWhE0JHYNTQOOB54w1QQBHhHWouxTTTS6/hVFNNKaCAmmtAJZXUTTlFFdVS Q6UgVU5XbZXTS5igtVYmYKVgVltr1XVXX3n1IR61cIwIgTswm4YHzLQx7bIGkMGsHK8uo2Q1UIjl MVttGSyCBREui4AceR5AoK43algCGhygqasNO3jhYYbm6FL2i1OMoOsXeOLgxZs2EFMELS7KocuG LzIhBTFjajHAE15AOJauSVaZhBdftpzLFGns6IEXIOi1wolzHJBCCLooeaaSGkjRAxe6lHhFCFQw YmMueZzYBeO6BHiikWdYoEuPblA4J45nvp2LilJQ+GKGV+Sa6xcp/ypwp5ZXxKBLjBh8CUCYV8qd qwEnnOBBiWd62TZttddmu223ExvhGRJQAPukHnAgqIIhZolOo0beaaGC57hYgJcAdhHijiIeIOEL iGoBE6ITZrRIkSVYwPftFRd5gSBpFCGhDWkauYIXYmx4ppOOCTqhhl0a0QOGEmBowBdUgJhBCGmi IUgCaSo4hJcnMrCBlwdKiUEVJzq8gndepImADRNeWQMFbqzoxAo0UGDBiWNgWMOKWZ4Z4gpuYCDF Cl00X5D4J2y5QpIruOimD0lgYEWPc8TohgpeuKCFGGbRjWg8QwpX+EM3BlYOITSCIOagxbFIIANe 2ABv3ZgHNJ7Rg1YZKEMaZyAILRphhQrOgAQikIYeTCAJaTxBBBF4BSCsYINJDMMJIyChK1zBPgZN iyD4MoIKfAERbHHkOeTYSBGKCBHdQCRzGskDLciiHILgpW9UHFFAAAA7 ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/math/ge.gif R0lGODlhBwAKAMIAAAAAACQkJElJSW1tbZKSkra2ttvb2////yH5BAEAAAcALAAAAAAHAAoAQAMa GHXc/mYQwwwZtIjlxn5MEQxHJFAlKAQsKyQAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pnas.org/icons/header/go.gif R0lGODlhEwASAMQAAABmZom4uDCDg+719brW1mWjoxBwcM7i4lWZmZnCwt7r63WsrP///0SPjyB5 earMzP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAUU ABAALAAAAAATABIAAAVZICCOZGmeaKqubJsKCzIaxSKgCUMoD2AoCgIjYCowCiIDIKcMMBylXCko ajAWJSFAyADoqteSE+CQEggio4xkxS66xobhMVCWEAeGIiEKDBgHNy6DhIWGhSEAOw== ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pnas.org/javascript/ajax/xmlhttprequest.js /*=0A= =0A= Cross-Browser XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pnas.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else if (name =3D=3D "margin-right") {=0A= e.style.marginRight =3D value;=0A= }=0A= else if (name =3D=3D "margin-top") {=0A= e.style.marginTop =3D value;=0A= }=0A= else if (name =3D=3D "min-height") {=0A= e.style.minHeight =3D value;=0A= }=0A= else if (name =3D=3D "overflow") {=0A= e.style.overflow =3D value;=0A= }=0A= else if (name =3D=3D "overflow-x") {=0A= e.style.overflowX =3D value;=0A= }=0A= else if (name =3D=3D "overflow-y") {=0A= e.style.overflowY =3D value;=0A= }=0A= else if (name =3D=3D "padding") {=0A= e.style.padding =3D value;=0A= }=0A= else if (name =3D=3D "padding-bottom") {=0A= e.style.paddingBottom =3D value;=0A= }=0A= else if (name =3D=3D "padding-left") {=0A= e.style.paddingLeft =3D value;=0A= }=0A= else if (name =3D=3D "padding-right") {=0A= e.style.paddingRight =3D value;=0A= }=0A= else if (name =3D=3D "padding-top") {=0A= e.style.paddingTop =3D value;=0A= }=0A= else if (name =3D=3D "page-break-after") {=0A= e.style.pageBreakAfter =3D value;=0A= }=0A= else if (name =3D=3D "page-break-before") {=0A= e.style.pageBreakBefore =3D value;=0A= }=0A= else if (name =3D=3D "pixelBottom") {=0A= e.style.pixelBottom =3D value;=0A= }=0A= else if (name =3D=3D "pixelHeight") {=0A= e.style.pixelHeight =3D value;=0A= }=0A= else if (name =3D=3D "pixelLeft") {=0A= e.style.pixelLeft =3D value;=0A= }=0A= else if (name =3D=3D "pixelRight") {=0A= e.style.pixelRight =3D value;=0A= }=0A= else if (name =3D=3D "pixelTop") {=0A= e.style.pixelTop =3D value;=0A= }=0A= else if (name =3D=3D "pixelWidth") {=0A= e.style.pixelWidth =3D value;=0A= }=0A= else if (name =3D=3D "posBottom") {=0A= e.style.posBottom =3D value;=0A= }=0A= else if (name =3D=3D "posHeight") {=0A= e.style.posHeight =3D value;=0A= }=0A= else if (name =3D=3D "position") {=0A= e.style.position =3D value;=0A= }=0A= else if (name =3D=3D "posLeft") {=0A= e.style.posLeft =3D value;=0A= }=0A= else if (name =3D=3D "posRight") {=0A= e.style.posRight =3D value;=0A= }=0A= else if (name =3D=3D "posTop") {=0A= e.style.posTop =3D value;=0A= }=0A= else if (name =3D=3D "posWidth") {=0A= e.style.posWidth =3D value;=0A= }=0A= else if (name =3D=3D "right") {=0A= e.style.right =3D value;=0A= }=0A= else if (name =3D=3D "ruby-align") {=0A= e.style.rubyAlign =3D value;=0A= }=0A= else if (name =3D=3D "ruby-overhang") {=0A= e.style.rubyOverhang =3D value;=0A= }=0A= else if (name =3D=3D "ruby-position") {=0A= e.style.rubyPosition =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-3dlight-color") {=0A= e.style.scrollbar3dLightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-arrow-color") {=0A= e.style.scrollbarArrowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-base-color") {=0A= e.style.scrollbarBaseColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-darkshadow-color") {=0A= e.style.scrollbarDarkShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-face-color") {=0A= e.style.scrollbarFaceColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-highlight-color") {=0A= e.style.scrollbarHighlightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-shadow-color") {=0A= e.style.scrollbarShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-track-color") {=0A= e.style.scrollbarTrackColor =3D value;=0A= }=0A= else if (name =3D=3D "float") {=0A= e.style.styleFloat =3D value;=0A= }=0A= else if (name =3D=3D "table-layout") {=0A= e.style.tableLayout =3D value;=0A= }=0A= else if (name =3D=3D "text-align") {=0A= e.style.textAlign =3D value;=0A= }=0A= else if (name =3D=3D "text-align-last") {=0A= e.style.textAlignLast =3D value;=0A= }=0A= else if (name =3D=3D "text-autospace") {=0A= e.style.textAutospace =3D value;=0A= }=0A= else if (name =3D=3D "text-decoration") {=0A= e.style.textDecoration =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationBlink") {=0A= e.style.textDecorationBlink =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationLineThrough") {=0A= e.style.textDecorationLineThrough =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationNone") {=0A= e.style.textDecorationNone =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationOverline") {=0A= e.style.textDecorationOverline =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationUnderline") {=0A= e.style.textDecorationUnderline =3D value;=0A= }=0A= else if (name =3D=3D "text-indent") {=0A= e.style.textIndent =3D value;=0A= }=0A= else if (name =3D=3D "text-justify") {=0A= e.style.textJustify =3D value;=0A= }=0A= else if (name =3D=3D "text-kashida-space") {=0A= e.style.textKashidaSpace =3D value;=0A= }=0A= else if (name =3D=3D "text-overflow") {=0A= e.style.textOverflow =3D value;=0A= }=0A= else if (name =3D=3D "text-transform") {=0A= e.style.textTransform =3D value;=0A= }=0A= else if (name =3D=3D "text-underline-position") {=0A= e.style.textUnderlinePosition =3D value;=0A= }=0A= else if (name =3D=3D "top") {=0A= e.style.top =3D value;=0A= }=0A= else if (name =3D=3D "unicode-bidi") {=0A= e.style.unicodeBidi =3D value;=0A= }=0A= else if (name =3D=3D "vertical-align") {=0A= e.style.verticalAlign =3D value;=0A= }=0A= else if (name =3D=3D "visibility") {=0A= e.style.visibility =3D value;=0A= }=0A= else if (name =3D=3D "white-space") {=0A= e.style.whiteSpace =3D value;=0A= }=0A= else if (name =3D=3D "width") {=0A= e.style.width =3D value;=0A= }=0A= else if (name =3D=3D "word-break") {=0A= e.style.wordBreak =3D value;=0A= }=0A= else if (name =3D=3D "word-spacing") {=0A= e.style.wordSpacing =3D value;=0A= }=0A= else if (name =3D=3D "word-wrap") {=0A= e.style.wordWrap =3D value;=0A= }=0A= else if (name =3D=3D "writing-mode") {=0A= e.style.writingMode =3D value;=0A= }=0A= else if (name =3D=3D "z-index") {=0A= e.style.zIndex =3D value;=0A= }=0A= else if (name =3D=3D "zoom") {=0A= e.style.zoom =3D value;=0A= }=0A= }=0A= catch (e) {=0A= /* ignore error on attempt to set e.style.[property] */=0A= }=0A= }=0A= }=0A= }=0A= ------=_NextPart_000_0035_01C67AAF.13833830 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pnas.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. For now we have to disable=0A= * the callback until we can track down a proper fix=0A= * (or everybody sanely upgrades to version 6 or 7!).=0A= */=0A= if (navigator) {=0A= var appname =3D navigator.appName;=0A= if (appname =3D=3D "Microsoft Internet Explorer") {=0A= var userAgent =3D navigator["userAgent"];=0A= var s =3D "MSIE ";=0A= var n =3D -1; =0A= if ((n =3D userAgent.indexOf(s)) !=3D -1) {=0A= var v =3D parseFloat(userAgent.substring(n+s.length));=0A= if (v < 6) {=0A= return;=0A= }=0A= }=0A= }=0A= }=0A= =0A= /*=0A= * Acquire table row element to update, initiate callback=0A= * to update table with Entrez Links.=0A= */=0A= var tr =3D document.getElementById('entrez_callback_'+pmid);=0A= if (!tr) {=0A= return;=0A= }=0A= var req =3D new XMLHttpRequest();=0A= if (!req) {=0A= return;=0A= }=0A= req.onreadystatechange =3D function() {=0A= if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || req.status = =3D=3D 304)) {=0A= var src =3D req.responseXML.documentElement;=0A= var dst =3D document.createDocumentFragment();=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], dst);=0A= }=0A= var tbl =3D tr.parentNode;=0A= tbl.replaceChild(dst, tr);=0A= }=0A= }=0A= req.open('GET', callback_url, true);=0A= req.send(null);=0A= }=0A= ------=_NextPart_000_0035_01C67AAF.13833830--