From: Subject: The Combination of Ionizing Radiation and Peripheral Vaccination Produces Long-term Survival of Mice Bearing Established Invasive GL261 Gliomas -- Newcomb et al. 12 (15): 4730 -- Clinical Cancer Research Date: Fri, 22 Feb 2008 14:42:58 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C87561.37926E40" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C87561.37926E40 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://clincancerres.aacrjournals.org/cgi/content/full/12/15/4730 The Combination of Ionizing Radiation and Peripheral = Vaccination Produces Long-term Survival of Mice Bearing Established = Invasive GL261 Gliomas -- Newcomb et al. 12 (15): 4730 -- Clinical = Cancer Research 3D"Clinical 3D"
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Clinical Cancer Research Vol. 12, 4730-4737, August 1, = 2006
=A9 2006 American = Association for Cancer Research

Cancer Therapy: = Preclinical

The Combination of Ionizing Radiation and Peripheral Vaccination = Produces=20 Long-term Survival of Mice Bearing Established Invasive GL261=20 Gliomas

Elizabeth W.=20 Newcomb1,5, Sandra=20 Demaria1,5, Yevgeniy=20 Lukyanov1, Yongzhao=20 Shao2,5, Tona = Schnee1,=20 Noriko Kawashima1, Li = Lan1,=20 J. Keith Dewyngaert3, David=20 Zagzag1,4,5, William H.=20 McBride6 and Silvia C.=20 Formenti3,5

Authors' Affiliations: Departments of = 1=20 Pathology, 2 Environmental Medicine, and 3 = Radiation=20 Oncology, 4 Division of Neuropathology and Neurosurgery, = 5=20 New York University Cancer Institute, New York University School of = Medicine,=20 New York, New York; and 6 Department of Radiation Oncology,=20 Experimental Division, University of California at Los Angeles School of = Medicine, Los Angeles, California

Requests for reprints: Elizabeth W. Newcomb, = Department=20 of Pathology, MSB-531, New York University School of Medicine, 550 First = Avenue,=20 New York, NY 10016. Phone: 212-263-8758; Fax: 212-263-8211; E-mail: = newcoe01{at}med.nyu.edu .


3D"   =20 Abstract
Top
3D"Abstract
Materials and Methods
Results
Discussion
References
 
<= B>Purpose:=20 High-grade glioma treatment includes ionizing radiation = therapy. The=20 high invasiveness of glioma cells precludes their eradication = and is=20 responsible for the dismal prognosis. Recently, we reported = the=20 down-regulation of MHC class I (MHC-I) products in invading = tumor=20 cells in human and mouse GL261 gliomas. Here, we tested the=20 hypothesis that whole-brain radiotherapy (WBRT) up-regulates = MHC-I=20 expression on GL261 tumors and enhances the effectiveness of=20 immunotherapy.

Experimental Design: MHC-I molecule expression on GL261 = cells=20 was analyzed in vitro and in vivo by flow cytometry = and=20 immunohistochemistry, respectively. To test the response of=20 established GL261 gliomas to treatment, mice with measurable = (at CT=20 imaging) brain tumors were randomly assigned to four groups = receiving=20 (a) no treatment, (b) WBRT in two fractions of = 4 Gy,=20 (c) vaccination with irradiated GL261 cells secreting=20 granulocyte-macrophage colony-stimulating factor, or = (d) WBRT=20 and vaccination. Endpoints were tumor response and = survival.=20

Results: An ionizing radiation dose of 4 Gy maximally=20 up-regulated MHC-I molecules on GL261 cells in vitro. In = vivo,=20 WBRT induced the expression of the =DF2-microglobulin light = chain=20 subunit of the MHC class I complex on glioma cells invading=20 normal brain and increased CD4+ and CD8+ T cell infiltration. = However, the survival advantage obtained with WBRT or = vaccination=20 alone was minimal. In contrast, WBRT in combination with = vaccination=20 increased long-term survival to 40% to 80%, compared with 0% = to=20 10% in the other groups (P < 0.002). Surviving animals=20 showed antitumor immunity by rejecting challenge tumors. =

Conclusion: Ionizing radiation can be successfully = combined=20 with peripheral vaccination for the treatment of established=20 high-grade gliomas.

Radiation therapy remains the principal approach for the treatment = of=20 adult patients with high-grade glioma and pediatric patients = with=20 brainstem gliomas, generally involving fractionated radiotherapy = with=20 total doses up to 60 Gy (1=964).=20 The addition of concurrent temozolomide to radiotherapy has = been=20 shown to significantly prolong the life of patients with=20 glioblastoma, but long-term survivors of this disease remains = extremely rare (5).=20

Because of the pressing need for adjunctive therapies to enhance = the effectiveness of radiation therapy for glioma, we have = developed=20 an experimental murine GL261 model that mimics the aggressive = and invasive growth observed in human brain tumors (6=968)=20 and whose growth can be monitored noninvasively by CT = imaging.=20 Using this model, we showed significant down-regulation of = MHC=20 genes in vivo in tumor cells invading normal brain tissue = in=20 comparison with the glioma cells in the core of the tumor, = similar=20 to what we had observed in human glioma (9).=20 We hypothesized that one of the mechanisms for invading = glioma cells=20 to defeat the host immune surveillance system is = down-regulating=20 expression of MHC molecules at the growing edge of the tumor. = The=20 general hypothesis of tumor immune surveillance was = originally=20 formulated by Burnet in 1970 (10).=20 It is now clear that there is a complex relationship between = the=20 host's immunosurveillance system and the ability of = transformed cells=20 to escape immune recognition and destruction (reviewed in = refs. 11=9614).=20 The ability of tumor cells to modulate the host's immune = response has=20 important implications for the development of = immunotherapies,=20 including the design of effective cancer vaccines (15,=20 16).=20

Recently, there has been growing interest in the interactions=20 between ionizing radiation (IR) and the immune system. = Several=20 studies have shown that irradiation of human and murine tumor = cell lines up-regulates the expression of numerous = immunologically=20 relevant molecules, including Fas, ICAM-1, MHC class I, and = the=20 human carcinoma-associated antigens, CEA and MUC-1 (17=9621),=20 which may make them better targets for immune recognition. In = the present study, we tested the hypothesis that a low dose = of=20 whole-brain radiotherapy (WBRT) of GL261 intracranial (i.c.) = tumors=20 may up-regulate MHC class I expression, as measured by the = surrogate=20 marker, =DF2-microglobulin, thus providing a target for a T=20 cell=96mediated antitumor immune response elicited by = vaccination. We=20 show significant increases in the long-term survival of mice = with=20 well-established i.c. GL261 gliomas treated with WBRT and=20 vaccination, concomitant with the development of antitumor = immunity.=20 The growing awareness that IR can make tumors more amenable = to immune=20 recognition has important implications for the development of = novel=20 immunotherapies. Importantly, the more insidious invading = tumor cells=20 that invariably lead to fatal relapse may be particularly = targeted as=20 a result of this strategy.


3D"   =20 Materials and Methods
Top
Abstract
3D"Materials and = Methods
Results
Discussion
References
 
<= B>GL261=20 glioma tumor cell line and reagents. The murine GL261 = glioma=20 cell line was obtained from the National Cancer Institute-Frederick = Cancer Research Tumor Repository (Frederick, MD). The cells=20 were transfected with the plasmid encoding the gene for green = fluorescent protein (GFP) according to the manufacturer's = protocol=20 (Clontech, Palo Alto, CA) and cultured in 5% CO2 and = 95%=20 humidified air atmosphere at 37=B0C in DMEM (Life = Technologies,=20 Grand Island, NY) supplemented with 10% fetal bovine serum=20 (Atlanta Biologicals, Norcross, GA), 0.25% gentamicin (Life=20 Technologies) and 1% L-glutamine (Life = Technologies) as described (7).=20 The GL261 cell line retrovirally transduced to secrete=20 granulocyte-macrophage colony-stimulating factor (GM-CSF) was = a kind=20 gift from Dr. X.O. Breakefield (22)=20 and was cultured as described for the nontransduced GL261 = cells. Both=20 GL261 glioma cell lines were split every 3 days to ensure = logarithmic=20 growth.

Flow cytometric analysis of the GL261 cell line. GL261=20 cells were plated (5 x=20 105/75 cm2 flask) and after 48 hours, the = flasks=20 were either irradiated (0, 2, 4, and 6 Gy) using a 60Co = source (Theratron 780-C; AECL Medical, Canada) or treated = with=20 IFN-3D{gamma} (150 pg/mL). Cells were harvested 72 hours after=20 irradiation in cold PBS containing 0.04% EDTA and processed = in=20 parallel for MHC expression by fluorescence-activated cell = sorting=20 (FACS) analysis or for mRNA gene expression by RT-PCR = analysis as=20 described below. For FACS analysis, cells were washed and = incubated=20 with phycoerythrin-conjugated anti-H2-Kb (clone = AF6-88.5),=20 phycoerythrin anti-H2-Db (clone KH95), and = phycoerythrin=20 anti-Fas/CD95 or isotype controls (all antibodies from BD = PharMingen,=20 San Jose, CA). Samples were analyzed using a FACSCalibur flow = cytometer (Becton Dickinson, Bedford, MA) and FlowJo 4.5.2 = software=20 (Ashland, OR).

Flow cytometric analysis of tumor-infiltrating cells. = To=20 determine the nature and number of immune cells infiltrating = GL261=20 tumors growing in the brain of mice, on day 23 = postimplantation,=20 two brains were harvested from each treatment group and=20 single-cell homogenates were prepared for FACS analysis. Each = brain=20 was removed and the tumor-bearing hemispheres were finely = minced=20 with a razor blade and then homogenized in 5 mL of PBS in a=20 Dounce homogenizer (7 mL, Pyrex, no. 7727-07). The homogenate = was drawn up into a 12 mL syringe fitted with a 21-gauge = needle=20 and passaged 10 times through the needle. The final cell = suspension=20 was filtered through a 40-=B5m nylon cell strainer (BD = Falcon,=20 San Jose, CA) into a 50 mL tube. The single-cell suspension = was=20 centrifuged at 400 x g for 10 = minutes=20 at room temperature. The pellet was resuspended in 4 mL of = 30%=20 isotonic Percoll and overlaid on a Percoll gradient and = centrifuged=20 at 500 x g for 20 = minutes as=20 described (23).=20 Lymphocytes were collected from the 37% to 70% interface, = washed once=20 in PBS and counted in a hemacytometer. Aliquots of cells (1 = x 105) were blocked in = 10%=20 normal mouse serum in PBS for 15 minutes at room temperature = followed=20 by incubation with phycoerythrin-conjugated antimouse = monoclonal=20 antibodies to CD4 T cells (clone GK1.5) and to natural killer = cells=20 (clone 01295A), and Cychrome-conjugated antimouse monoclonal = antibody=20 to CD8 T cells (clone 53-6.7) for 30 minutes on ice. All = antibodies=20 were purchased from BD PharMingen. Cells were washed once in = PBS,=20 resuspended in 1% paraformaldehyde, and stored at 4=B0C until = analyzed=20 by FACS analysis using a FACSCalibur flow cytometer (Becton=20 Dickinson).

To obtain the total number of lymphocytes, we took the total=20 number of viable cells isolated from the two pooled brains = (control,=20 3.7 x 105; WBRT, = 8.0 x 105) and multiplied by the=20 percentage of cells in the lymphocyte gate (Fig.=20 3A; control, 44.5% gated represents 1.65 x 105; WBRT, 60.3% gated = represents 4.82=20 x 105). This = number of=20 total lymphocytes was then multiplied by the percentage of = cells in=20 the lymphocyte gate positive for CD4+, CD8+, or NK1.1 to = obtain the=20 total number of lymphocytes in each subset depicted as a bar = graph=20 (Fig.=20 3B).



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  = 		Fig. 3. IR increases=20 tumor-infiltrating lymphocytes into GL261 tumors. GL261 = cells were=20 implanted i.c. on day 0, and mice were either left untreated = (Control) or given WBRT of 4 Gy on days 15 and 17=20 (WBRT). On day 23, brains were harvested and the=20 lymphocyte-enriched fractions were collected as described in = Materials and Methods and stained with phycoerythrin-Cy5 = anti-CD8,=20 and phycoerythrin anti-CD4 or anti-NK1.1 monoclonal = antibodies,=20 followed by flow cytometry analysis. A, the = lymphocyte gate=20 was set based on the scatter plots of spleen cells. = Representative=20 data from one of two groups of mice. B, the total = number of=20 CD4, CD8, and natural killer cells were calculated based on = the=20 total viable cells recovered from each group, and multiplied = by the=20 percentage of gated lymphocytes as described in Materials = and=20 Methods; columns, number of cells in each subset. =

 = ;
RNA=20 isolation and reverse transcription-PCR. Total RNA was = isolated=20 from suspension cultures of GL261 cells (see above for FACS=20 analysis) using the RNeasy kit (Qiagen Inc., Valencia, CA) = according=20 to the manufacturer's directions. RNA was quantitated by = absorbance=20 at 260 nm. Two micrograms of total RNA was = reverse-transcribed=20 using Super Script II RNase H reverse transcriptase = (Invitrogen,=20 Carlsbad, CA) and random hexamer primers (Invitrogen) at = 25=B0C=20 for 10 minutes and 42=B0C for 1 hour for cDNA synthesis. Two=20 microliters of the reverse transcription product was used as = a=20 template for PCR amplification. PCR was done under standard=20 conditions in a 50 =B5L reaction mix containing 1x PCR buffer, 1 unit of = Platinum Taq=20 polymerase (Invitrogen), 200 =B5mol/L of deoxynucleotide = triphosphate=20 mix, 1.5 mmol/L of MgCl2, and 150 nmol/L of=20 H-2Kb primers (5-GGAAAAGGAGGGGACTATGC-3, sense;=20 5-TCCATAAGGCTCACAGGGAAC-3, antisense), or 25 nmol/L of = =DF-actin=20 primers (5-CACAGGGGAGGTGATAGCAT-3, sense; = 5-TCAAGTTGGGGGACAAAAG-3,=20 antisense). The PCR conditions consisted of 3 minutes of an=20 initial denaturation step (95=B0C) followed by 25 cycles of=20 denaturation (95=B0C, 30 seconds), annealing (55=B0C, 30 = seconds),=20 and extension (72=B0C, 50 seconds) followed by a final = elongation step=20 of 7 minutes at 72=B0C. Twenty microliters of PCR product was = analyzed=20 on 3% agarose gels stained with ethidium bromide. = Quantitation of=20 bands was done with the Bio-Rad Fluor-S apparatus (Bio-Rad, = Hercules,=20 CA) with Quantity One (version 4.2.1) software.

Immunohistochemistry. Single and double label=20 immunohistochemistry was done using the NexES automated = immunostainer=20 and detection systems (Ventana Medical Systems, Tucson, AZ).=20 Formalin-fixed, paraffin-embedded, 6 =B5m sections were = deparaffinized=20 in xylene (three changes), rehydrated through a graded series = of=20 alcohols, and rinsed in distilled water. All incubations were = carried out at 37=B0C, unless noted otherwise.

To detect MHC class I expression in mouse tissue, sections were=20 immunostained with rabbit anti-human/mouse =DF2-microglobulin = antibody (Novocastra Laboratories, Newcastle upon Tyne, = United=20 Kingdom). This antibody reacts with the light chain component = of MHC class I molecules (9).=20 Antigen retrieval was done by proteolytic enzyme digestion = (alkaline=20 endopeptidase, 0.5 units/mL; Ventana Medical Systems) for 4 = minutes.=20 Endogenous peroxidase was blocked by the application of = hydrogen=20 peroxide for 4 minutes at 37=B0C. Anti-=DF2-microglobulin was = diluted=20 1:1,000 and =DF2-microglobulin antibody was detected by = the=20 application of a secondary biotinylated goat anti-mouse = (Ventana=20 Medical Systems) for 8 minutes, followed by the application = of=20 streptavidin-horseradish peroxidase for 8 minutes. The chromogen,=20 3,3'-diaminobenzidine/hydrogen peroxide mix was applied for = 8=20 minutes and then enhanced with copper sulfate for 4 minutes. = Slides=20 were then counterstained in hematoxylin, dehydrated, and = mounted with=20 Permount.

GL261 glioma cells expressing GFP were used to detect tumor = cells=20 invading the brain adjacent to the tumor. Tissue sections = were=20 immunostained with mouse anti-GFP (clone GFP01; Neomarkers, = Fremont,=20 CA). Antigen retrieval was done by microwaving tissue = sections in=20 0.01 mol/L (pH 6.0) citrate buffer for 20 minutes in a 1,200 = W=20 microwave oven. Slides were allowed to cool to room = temperature, then=20 washed in 0.05 mol/L Tris-HCl (pH 7.6) containing 0.3 mol/L = NaCl.=20 Endogenous peroxidase was blocked by the application of = hydrogen=20 peroxide for 4 minutes at 37=B0C. For double label=20 immunohistochemistry, tumor sections were first stained with=20 =DF2-microglobulin. Heat-induced antigen retrieval was done = as=20 described above. Next, slides were incubated with anti-GFP = antibody=20 diluted 1:300 and incubated overnight at room temperature. = GFP=20 antibody was detected as described above using alkaline = phosphatase=20 fast red as chromogen.

To evaluate lymphocyte populations in brain tissue, tissue = sections=20 were immunostained with mouse anti-human CD3 (clone PS2, = Novocastra=20 Laboratories). Antigen retrieval was done by microwaving = tissue=20 sections in 0.01 mol/L (pH 6.0) citrate buffer for 10 minutes = as described above. Endogenous peroxidase was blocked by the=20 application of hydrogen peroxide for 4 minutes at 37=B0C.=20 Anti-CD3 was diluted 1:200, incubated for 30 minutes at room=20 temperature, and then anti-CD3 antibody was detected by the=20 application of a secondary biotinylated goat anti-mouse = (Ventana=20 Medical Systems) for 8 minutes, followed by the application = of=20 streptavidin-horseradish peroxidase for 8 minutes. The chromogen,=20 3,3'-diaminobenzidine/hydrogen peroxide mix was applied for = 3=20 minutes.

Animals and i.c. tumor implantation. Female C57BL/6 = mice=20 were obtained from Taconic (Germantown, NY) and maintained = under=20 aseptic conditions in microisolator cages in facilities = approved=20 by the American Association for Accreditation of Laboratory=20 Animal Care in accordance with the current regulations and = standards=20 of the U.S. Department of Agriculture, The Department of = Health=20 and Human Services, and the NIH. Animal studies were done = under=20 an approved protocol by the Institutional Animal Care and Use = Committee. The animals were allowed food and water ad = libitum.=20 GL261 cells were cultured to subconfluence, trypsinized, = washed=20 twice in DMEM without serum, and resuspended in DMEM for = inoculation=20 into animals.

To establish i.c. tumors, GL261 glioma cells were implanted = in the=20 brains of 10- to 12-week-old female C57BL/6 mice (20 g) as = described=20 (24).=20 Briefly, animals were anesthetized with an i.p. injection of = xylazine=20 (80 mg/kg) and ketamine (10 mg/kg) and a burr hole was = drilled in the=20 skull 0.1 mm posterior to the bregma and 2.3 mm lateral to = the=20 midline. GL261 cells (5 x = 107/mL) in 2 =B5L of medium were inoculated = stereotactically=20 using a head frame (David Kopf Instruments, Tujunga, CA) in = the=20 defined location of the caudate/putamen (0.1 mm posterior to = the=20 bregma, 2.3 mm lateral to the midline) using a 10 =B5L = Hamilton syringe=20 (Reno, NV) with a 1-in. 30-gauge needle attached and inserted = into a=20 Kopf microinjection unit (Model 5000 with Model 5001 Hamilton = syringe=20 holder). The needle was advanced to a depth of 2.3 mm from = the brain=20 surface and the cell suspension was delivered slowly over the = course=20 of 3 to 4 minutes. Following injection, the needle was left = in place=20 for 2 minutes, after which time, it was raised to a depth of = 1.5 mm=20 below the brain surface and left in place for an additional 1 = minute.=20 Upon withdrawal of the needle, the burr hole was immediately = sealed=20 with bone wax and the incision sutured. Animals were randomly = assigned into control and treatment groups (n =3D = 5/group).=20 Animals were observed weekly and when they showed signs of = neurologic=20 deficit (lethargy, failure to ambulate, or lack of feeding=20 resulting in loss of >20% body weight) they were = sacrificed.=20 Prior to sacrifice, the animals were anesthetized and then=20 perfused transcardially with PBS followed by 4% = paraformaldehyde.=20 Brains were removed and placed in cold 4% paraformaldehyde=20 overnight, then sliced into 2 mm coronal sections prior to = processing=20 and embedding in paraffin. Tumors were measured grossly in = three=20 orthogonal axes to determine tumor volumes. H&E-stained=20 coronal sections were used as a check of tumor volumes and = for=20 overall tumor histopathology.

CT imaging. Animals were anesthetized with xylazine and = ketamine, as described above, prior to imaging the brain = using a CT=20 scanner (GE LightSpeed Qx/i). Animals received an = intraorbital=20 injection of contrast agent (100 =B5L; Conray, Mallinckrodt, = Inc.,=20 St. Louis, MO) and within 10 minutes of contrast injection,=20 axial images of the brain were acquired using the CT scanner = to=20 detect the presence of brain tumors. Contrasted tumors appear = as=20 regions of brighter intensity (similar to that of the bone = tissue, in=20 the animal skull) in the CT scan compared with surrounding = brain=20 tissue which appears dark due to lower intensity.

Preparation of the GL261 vaccine. To analyze the = secretion=20 of GM-CSF into the medium, cells (5 x 105) were plated in a 60 = mm=20 dish in 2.5 mL of medium. After 24 hours, the supernatant was = harvested and either stored at =9680=B0C or tested directly = by ELISA for=20 GM-CSF using a commercial ELISA kit (R&D System, = Minneapolis, MN)=20 according to the manufacturer's instructions. The GM-CSF = transduced=20 cells that we obtained secreted 100 ng/106 = cells/24 hours=20 GM-CSF, similar to the original report (22).=20 For vaccine preparation, GL261 cells were irradiated with 25 = Gy=20 in 75 cm2 flasks, using a 60Co source (Theratron = 780-C,=20 AECL Medical), trypsinized, washed, and inoculated s.c. into = the=20 left and right flanks of mice (2.5 x=20 106/100 =B5L/injection in the inguinal = regions).

WBRT combined with GL261 peripheral vaccine treatment. = In=20 the first experiment, on day 12 post-i.c. implantation, = animals=20 were randomly assigned to four treatment groups (n =3D = 5/group):=20 (a) control with sham radiation, (b) WBRT given in = two=20 fractions of 4 Gy, 48 hours apart on days 12 and 14, = (c)=20 vaccination treatment given on both flanks with irradiated = (25 Gy)=20 GL261 tumor cells secreting GM-CSF on day 14 after i.c. tumor = cell=20 implantation, (d) WBRT + vaccination treatment, where=20 peripheral vaccination was given a few hours after the = animals had=20 received their second fraction of WBRT on day 14. WBRT was = delivered=20 to the head of the mouse centered in a 5 cm radiation field = using a=20 60Co radiation source (Theratron 780-C, AECL = Medical) on=20 days 12 and 14 postimplantation.

In the second experiment, CT on day 15 post-i.c. implantation,=20 when tumors were large enough to be reliably measured, was = used=20 to compute tumor volumes. Images were digitally transferred = to=20 a Varian Eclipse radiation planning system workstation and = tumor=20 volumes were calculated using the formula for ellipsoid = volume. Two=20 dimensions (in frontal plane) were measured directly and the = third=20 dimension was measured using three-dimensional reconstructing = feature=20 of the planning system. Animals were assigned to four = treatment=20 groups (n =3D 5/group) so that the mean tumor volumes = were 3.5=20 mm3 (range, 2.1-4.8) in all groups. The groups = consisted=20 of (a) control with sham irradiation, (b) WBRT, = given=20 in two fractions of 4 Gy, 48 hours apart on days 15 and 17,=20 (c) vaccination as described above on day 17, and = (d)=20 WBRT + vaccination, where peripheral vaccination was given a = few=20 hours after the animals had received their second fraction of = WBRT on=20 day 17. On day 28, tumor volume was assessed by CT. On day = 60,=20 control "na=EFve" 6- to 8-week-old female C57BL/6 mice or = surviving=20 animals were challenged by s.c. injection in the hind limb of = 2 x 106 cells in 0.05 mL of = serum-free=20 media. We chose to evaluate antitumor immunity in the = long-term=20 survivors using s.c. rather than i.c. tumor rechallenge in = order to=20 assess their systemic state of immunity. Tumor growth was=20 measured twice weekly using calipers and tumor volumes were=20 calculated using the formula (length x width2) / 2, where the length = represents the longest axis and the width was measured at = right=20 angles to the length. Animals were observed for an additional = 60=20 days and/or sacrificed when tumor volumes reached 900 to = 1,200=20 mm3. Brains from "cured" animals were removed and=20 processed for histopathology.

Statistics. Kaplan-Meier survival curves with a = log-rank=20 test were used to compare the survival proportions of the = four=20 treatment groups (control, WBRT, vaccination, and WBRT +=20 vaccination). Differences were considered significant at = P=20 < 0.05.


3D"   =20 Results
Top
Abstract
Materials and Methods
3D"Results
Discussion
References
 
<= B>IR=20 up-regulates MHC class I expression on GL261 glioma cells = in=20 vitro. We recently reported that invading GL261 glioma tumor=20 cells in the brain down-regulate MHC class I expression, a = molecule=20 required for recognition by CTLs (9).=20 We investigated whether irradiation could reverse this low=20 expression, as has been reported for other cell lines in = vitro=20 (17),=20 GL261 cells were irradiated with different doses of IR (0, 2, = 4, or 6=20 Gy) or treated with IFN-3D{gamma}=20 = (150 pg/mL)=20 as a positive control (25,=20 26).=20

Irradiation of GL261 cells increased surface MHC class I=20 H-2Kb expression 72 hours after irradiation (Fig.=20 1A ). Treatment with 4 or 6 Gy induced similar increases = in=20 H-2Kb expression, whereas 2 Gy was less effective = (data=20 not shown). Expression of H-2Db on GL261 was = undetectable=20 on untreated cells and was not induced by radiation. = Similarly, there=20 was no induction of Fas/CD95 molecules after irradiation = (data not=20 shown). As expected, IFN-3D{gamma}=20 = markedly=20 increased the surface expression of both H-2Kb and = H-2Db MHC class I molecules. Up-regulation of the=20 H-2Kb MHC protein complex at the cell surface by IR or = IFN- treatment was accompanied by increased levels of=20 H-2Kb mRNA gene expression as assessed by RT-PCR = (Fig.=20 1B).



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  = 		Fig. 1. IR induces = up-regulation of=20 MHC expression in GL261 glioma cells in vitro as = shown by=20 (A) FACS analysis and (B) RT-PCR. Using FACS = analysis,=20 GL261 cells treated with 4 Gy or IFN-3D{gamma}=20=20 show up-regulation of MHC expression (black = histogram)=20 compared with untreated cells (gray histogram). The=20 up-regulation of cell surface antigen expression for MHC was = correlated with increased gene transcription. =

 = ;
IR=20 up-regulates =DF2-microglobulin expression on GL261 glioma = cells in=20 vivo. GL261-GFP tumor cells were used to identify glioma = cells in=20 the brain and to test whether irradiation would increase the=20 expression of MHC in vivo. WBRT was delivered to the = brains of=20 mice on days 12 and 14 after implantation, when tumors were = 4 =B1 1=20 mm3 in volume (24).=20 On the basis of our in vitro MHC expression data, we = selected=20 two 4-Gy doses 48 hours apart for the in vivo = treatments.=20 Brains were harvested 48 hours following the second fraction = of WBRT=20 and processed for immunohistochemistry as described = previously (9).=20 We used double-labeled immunohistochemistry to visualize=20 GFP-positive tumor cells invading the brain adjacent to tumor = (Fig.=20 2A ) and expression of the light chain of the=20 =DF2-microglobulin complex to assess MHC class I expression. = Brains=20 from one representative control and one WBRT animal of a = group of=20 four animals are shown (Fig.=20 2). In untreated mice, there was no detectable expression = of=20 =DF2-microglobulin by the invading tumor cells (Fig.=20 2B). In contrast, following WBRT, there was strong = surface=20 staining of the invading tumor cells, consistent with = up-regulation=20 of MHC class I complexes (Fig.=20 2C).



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  = 		Fig. 2. IR induces = up-regulation of=20 =DF2-microglobulin expression in GL261 glioma cells in = vivo. A,=20 invasive growth pattern of GL261 tumors. Tissue sections = were=20 stained for GFP to reveal GL261 tumor cells (red = label;=20 magnification, x100). = C,=20 double label immunohistochemistry analysis of MHC expression = (brown label) on GFP-positive GL261 tumor cells = (red=20 label). B, representative brains from a control = animal or=20 48 hours after WBRT treatment with two fractions of 4 Gy are = shown=20 (magnification, x100). = Insets, one=20 representative GFP-positive GL261 tumor cell invading the = brain=20 adjacent to tumor (BAT) in control (red label = only)=20 compared with one representative GFP-positive GL261 tumor = cell=20 invading the BAT from a WBRT animal showing coexpression of = GFP and=20 =DF2-microglobulin (double red and brown = label;=20 magnification, x400). =

 = ;
IR=20 increases lymphocytes infiltrating GL261 tumors. A possible = consequence of the administration of IR is the induction of = an=20 inflammatory response (27=9630).=20 To test this, mice were randomly assigned to receive mock = treatment=20 or WBRT given in two doses of 4 Gy on days 15 and 17 = post-i.c. tumor=20 implantation. Brains were harvested 7 days later and = single-cell=20 suspensions were prepared and partially purified on Percoll = gradients=20 for the analysis of lymphocyte subsets by flow cytometry (Fig.=20 3 ). Representative data from one of two groups of = control or=20 WBRT animals are shown. The contamination with GFP-positive=20 tumor cells in the lymphocyte gate was <1% in all samples=20 (data not shown). The numbers of CD4+, CD8+, and natural = killer=20 cells recovered from brain tumors of control and irradiated = mice=20 are shown in the bar graph (Fig.=20 3B). There was a 4-fold increase in the number of CD4+ = and a=20 4.5-fold increase in CD8+ T cells in the brain tumors of = irradiated=20 mice, whereas natural killer cells showed a small increase = compared=20 with brain tumors of control mice.

Increased tumor-free survival of animals bearing i.c. = GL261=20 tumors treated with WBRT combined with peripheral=20 vaccination. Vaccination with irradiated autologous = tumor=20 cells transduced to secrete GM-CSF has been shown to induce a = T=20 cell=96mediated antitumor response against GL261 glioma (31).=20 The elicited immune response, which is mediated, at least in = part, by=20 CD8+ T cells can inhibit the growth of early brain tumors (31).=20 To test whether WBRT can increase the susceptibility of = established=20 invasive GL261 glioma to the antitumor immune response = elicited by=20 vaccination, we used the treatment protocol shown in the = schema (Fig.=20 4A ). At day 12 after i.c. implantation, animals were = randomly=20 assigned to four treatment groups: (a) control, = (b)=20 WBRT given in two fractions of 4 Gy, (c) vaccination = with=20 irradiated GL261 cells transduced to secrete the cytokine = GM-CSF, and=20 (d) WBRT + vaccination. The mean survival time was 33 = =B1 7 days=20 for control animals, 55 =B1 24 days for animals treated with=20 fractionated WBRT alone, and 45 =B1 21 days for animals = treated with=20 vaccination only (Fig.=20 4B). In the group treated with WBRT + vaccination, 80% of = the=20 animals had long-term survival times of >75 days compared = with=20 only 10% in the other treatment groups. This difference in = overall=20 survival was statistically significant (P < 0.002). =



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  = 		Fig. 4. Increased = tumor-free=20 survival of animals bearing i.c. GL261 tumors treated with = whole=20 brain fractionated radiation combined with peripheral = vaccination.=20 A, schema outlining the treatments used in the = experiments.=20 B, Kaplan-Meier survival curves of animals in the = different=20 treatment groups. C, animals "cured" by the different = treatments were rechallenged on day 75 of i.c. implantation = with=20 s.c. injection of 2 x=20 106 GL261 cells in the hind limb. Normal growth = of GL261=20 tumors was monitored by injection of cells into na=EFve = mice. The=20 overall survival of na=EFve and rechallenged animals was = followed for=20 8 weeks. =

 = ;
To=20 test whether the long-term survivors had developed effective = systemic=20 antitumor immunity, all surviving animals were rechallenged = with=20 viable GL261 cells in the hind limb and observed for tumor=20 development for an additional 8 weeks (Fig.=20 4C). All five of the na=EFve animals developed tumors by = day 28. In=20 contrast, none of the long-term survivors from the different=20 treatment groups developed tumors, indicating that these = animals had=20 developed immunologic memory capable of rejecting GL261 = tumor.=20

Radioresponse of established i.c. GL261 tumors treated = with=20 WBRT combined with peripheral vaccination. In a subsequent = experiment, CT scanning was used to image the i.c. tumors and = follow=20 the kinetics of tumor response to treatment. CT scanning was=20 first done on day 15 after implantation, at which time, = tumors=20 were usually large enough to be reliably visualized. Animals=20 were then assigned to four treatment groups (control, WBRT,=20 vaccination, or WBRT + vaccination), such that the tumor = volumes were=20 comparable between groups. Treatment was administered as = described=20 above (Fig.=20 4A) except that WBRT was given on days 15 and 17, and = vaccination=20 on day 17. Representative CT scans from animals prior to = treatment on=20 day 15 and after treatment on day 28 are shown (Fig.=20 5A , arrows indicate tumors) together with the = Kaplan-Meier=20 survival curves (Fig.=20 5B). The mean survival was 33 =B1 3 days for control = animals, 37 =B1=20 7 days for animals treated with fractionated WBRT alone, and = 34=20 =B1 6 days for animals treated with vaccination only. The = survival=20 advantage observed following WBRT or vaccination alone was = less=20 than in the previous experiment (Fig.=20 4B), suggesting that a delay of only a few days in = treatment and=20 correspondingly larger tumors dramatically reduces the = effectiveness=20 of vaccination and radiation as single modalities. = Importantly,=20 although the group treated with WBRT + vaccination had an = overall=20 reduced survival advantage as compared with the previous=20 experiment (Fig.=20 4B), 40% of the animals experienced long-term survival as = compared with none of the animals in the other treatment = groups. This=20 difference in overall survival was statistically significant=20 (P < 0.002). Again, the long-term survivors failed = to=20 develop tumors upon rechallenge with GL261 glioma cells in = the hind=20 leg after 60 days compared with the controls.



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  = 		Fig. 5. Radioresponse of=20 established i.c. GL261 tumors treated with whole brain = fractionated=20 radiation combined with peripheral vaccination. A, CT = scans=20 of representative animals at day 15 prior to initiation of=20 treatments and again on day 28 of the same animals showing = their=20 response to a given treatment. Arrows, contrasted tumors. = B,=20 Kaplan-Meier survival curves of animals in the different = treatment=20 groups. =

 = ;

3D"   =20 Discussion
Top
Abstract
Materials and Methods
Results
3D"Discussion
References
 
O= ur=20 previous work has shown that the murine GL261 cell line can = be used=20 to develop a valid transplantable orthotopic model of human = glioma.=20 Traditionally, mouse models of glioma have primarily used = xenografts=20 of human glioma cell lines implanted i.c. into = immunoincompetent mice=20 (32).=20 As a result, they have been unable to test immunotherapeutic=20 strategies (33).=20 Furthermore, such tumors do not show the invasive phenotype=20 characteristic of human gliomas that is often associated with = treatment failure (33).=20 In contrast to the xenograft models, GL261 tumors show = extensive=20 invasion into the brain parenchyma adjacent to the tumor with = visible=20 single or multiple tumor cells advancing into the brain along = vascular channels (7,=20 9).=20 The derivative of GL261 expressing GFP was used to readily = identify=20 invading tumor cells (7).=20 Although GFP can be immunogenic, our data show that it does = not=20 change the tumorigenicity of this poorly immunogenic glioma = (7).=20 Moreover, using neuroimaging techniques, including perfusion = MRI, we=20 have documented a correlation between tumor growth, relative = cerebral=20 blood volume, microvascular density, and histologic features=20 associated with the highly angiogenic nature of the GL261 = tumors (34).=20

Contrary to the earlier belief that the brain was refractory = to=20 infiltration with immune cells, there is now ample evidence = that=20 immune cells can traffic to the brain and affect the growth = of=20 experimental gliomas (35=9637).=20 More than a decade ago, it was shown that peripheral = vaccination with=20 cytokine-secreting autologous tumor cells could induce an = immune=20 response against the intracerebral tumor in experimental = animals (38).=20

In the current study, we used GL261 glioma cells transduced = to=20 secrete the cytokine GM-CSF as a vaccine. Vaccination with = tumor=20 cells modified to secrete GM-CSF has been shown to be = effective in=20 several preclinical cancer models, as well as in clinical = trials in=20 generating a systemic and durable antitumor immune response = (reviewed=20 in ref. 39).=20 In an experimental setting of well-established, = radiologically=20 detectable i.c. tumors, the combination of the vaccine with = WBRT was=20 superior to either treatment alone. Similar data were = obtained by=20 Lumniczky et al. (31).=20 However, in their study, treatment was given 3 days following = i.c.=20 implantation of GL261, at a time when the tumor was unlikely = to be=20 well established. To better mimic the clinical setting, we = elected to=20 study GL261 glioma tumors when they were firmly established, = as=20 documented by CT imaging.

Time after implantation and tumor size are critical factors=20 affecting the therapeutic response to vaccination, as shown = by=20 the fact that 40%, 10%, and 0% of mice treated with vaccination = alone=20 achieve long-term survival when vaccine is given on days 3, = 14, and=20 17, respectively (ref. 31;=20 Figs.=20 4 and 5).=20 Although we do not know whether delayed vaccination elicits = an=20 antitumor immune response of the same magnitude as = vaccination given=20 earlier in the course of tumor growth, the response is = sufficient=20 to obtain a therapeutic effect when combined with WBRT. GL261 = gliomas are relatively radioresistant tumors = (TCD50 =3D 65=20 Gy; ref. 8).=20 Consequently, the modest dose of radiation used in our = experiments=20 is unlikely to have resulted in sufficient cell death to = explain=20 the clinical response observed (Fig.=20 5B), suggesting that its major effect may indeed have = been to=20 facilitate infiltration and/or recognition of tumor cells by=20 antitumor T cells. Our studies identify one possible = mechanism=20 whereby this could occur in that radiation treatment = up-regulated the=20 expression of MHC class I H2-Kb and = =DF2-microglobulin=20 molecules on GL261 glioma cells in vitro and in = vivo,=20 respectively. In vitro, treatment with 4 Gy was = sufficient to=20 up-regulate the expression of H2-Kb but not=20 H2-Db molecules on GL261 cells. Differential regulation = of=20 H2-K and H2-D locus products by radiation has been previously=20 reported in the B16 melanoma model (40).=20 Other studies using sublethal doses of radiation on a wide = variety of=20 human cancer cell lines also showed up-regulation of one or = more=20 surface molecules involved in T cell=96mediated immune = responses,=20 including MHC class I, Fas, ICAM-1, CEA, and MUC-1 (17=9621).=20 Increase of MHC class I expression on GL261 cells has been = shown=20 to confer greater sensitivity to tumor-specific CTLs in = vitro,=20 as shown by using T cells specific for the = melanoma-associated=20 antigen gp100 expressed by GL261 cells (41).=20

Significantly, irradiation induced the expression of = =DF2-microglobulin=20 on invading GL261 glioma cells in vivo (Fig.=20 2C), a surrogate marker used in this study for MHC class = I=20 expression. The finding of very low MHC class I expression on = glioma=20 cells invading the normal brain tissue (9)=20 of nonirradiated mice could, at least in part, be responsible = for the=20 resistance of established tumors to antitumor T cells = elicited by=20 vaccination (Fig.=20 5B). Therefore, it is possible that the significant tumor = response, as determined by CT imaging and increased survival, = among=20 the mice treated with WBRT and vaccination is due to the=20 increased susceptibility of irradiated GL261 to antitumor T = cells (Fig.=20 5B). Nevertheless, other radiation-induced changes in = brain=20 tumor microenvironment are likely to contribute to the=20 therapeutic benefit of the combination treatment. For = instance, the=20 observed influx of inflammatory cells, including CD4+ and = CD8+ T=20 cells in response to local radiation (Fig.=20 3) may be triggered by local production of cytokines and = other=20 inflammatory signals in addition to the up-regulation of = vascular=20 adhesion molecules (reviewed in ref. 30).=20 Moreover, we cannot exclude the possibility that the effects = of=20 radiation not only on the tumor but also on normal brain = tissue,=20 which was included in the radiation field, contribute to the = observed=20 results. MHC class I antigens are usually not expressed in = the=20 central nervous system, but they might be induced by = radiation.=20 However, by immunohistochemistry, we did not detect the = expression of=20 =DF2-microglobulin in the normal brain adjacent to the = irradiated=20 tumor, suggesting that an autoimmune response is unlikely to = be=20 generated and a true therapeutic benefit might result from = the=20 combination of radiation treatment with a vaccination = strategy.=20

Immunotherapy of brain tumors is rapidly emerging as a viable=20 clinical option (42),=20 but its use as a first-line approach remains controversial = (43).=20 At least two "proof of principle" studies have been reported = using=20 vaccines prepared from the patients' autologous irradiated = glioma=20 tumor cells admixed with GM-CSF or IL-4-secreting fibroblasts = (44,=20 45).=20 In a phase I clinical trial using tumor vaccination plus = adoptive T=20 cell immunotherapy for patients with newly diagnosed = malignant=20 gliomas, several objective clinical responses were observed = without=20 any long-term toxicities (44).=20 More recently, several groups have developed dendritic cell = vaccines,=20 using either acid-eluted peptides from glioblastoma = multiforme cell=20 cultures developed from the surgical specimen or from crude = tumor=20 lysates (45=9648).=20 In several patients, a systemic CTL response was detected, = and in=20 some cases, tumor-infiltrating lymphocytes were also observed = in=20 the resection specimen obtained at relapse. Despite the = occurrence=20 of sporadic objective responses and some modest increase in = the=20 patient's survival, no long-term survivors have emerged from = these=20 approaches (45=9648).=20

Presumably, established invasive gliomas escape immune = recognition=20 through multiple mechanisms. One of them is low expression of = MHC class I molecules, as we have previously reported in all=20 grade 4 human gliomas (9).=20 Findings from studies in other tumor types also emphasize the = importance of MHC class I expression by the tumor cells in = eliciting=20 an effective immune response. A recent study of 124 stage IV = melanoma=20 patients shows that infiltration of tumors by CD4+ and CD8+ T = cells=20 correlated with the expression of MHC class I by the tumor = cells and=20 was associated with a better prognosis (49).=20 Similar findings were reported in another study of head and = neck=20 tumor patients, in which a positive correlation was found = between MHC=20 class I expression, the presence of tumor-infiltrating = lymphocytes,=20 and a better prognosis (50).=20 These data support the hypothesis that a strategy to enhance = the=20 expression of MHC class I molecules on tumor cells may = increase the=20 efficacy of cancer vaccines.

In summary, our results show that IR increases the expression = of=20 MHC class I on GL261 glioma cells in vitro and increases = the=20 expression of =DF2-microglobulin in vivo. When radiotherapy = is=20 combined with peripheral vaccination, it achieves significant=20 long-term survival rates in animals bearing established, = measurable=20 i.c. tumors with an invasive phenotype. These results also = show=20 that the GL261 glioma model is a relevant preclinical model = for=20 further exploring the mechanisms associated with radiation-induced=20 antitumor immunity. The preclinical evidence presented offers = promise to a clinical translation. The fact that modest doses = of radiation were required to recover MHC class I expression=20 supports the safety of combining radiotherapy in trials of=20 immunotherapy for patients with recurrent high-grade gliomas = who are=20 likely to have already received first-line radiotherapy. =


3D"   =20 Footnotes
 
Grant support: NIH Research grants = NS-57829=20 (E.W. Newcomb), CA-100426 (D. Zagzag), KO8 CA-89336 and = American=20 Cancer Society grant RSG-05-145-01-LIB (S. Demaria); = Department of=20 Defense grant W8IXWH-04-1-0905 and American Cancer Society = grant=20 TURSG CCE 103174 (S.C. Formenti).

The costs of publication of this = article were=20 defrayed in part by the payment of page charges. This article = must=20 therefore be hereby marked advertisement in accordance = with 18=20 U.S.C. Section 1734 solely to indicate this fact.

Note: E.W. Newcomb and S. = Demaria=20 contributed equally to this work.

Received 3/10/06; revised 4/21/06; accepted 5/ 4/06.


3D"   =20 References
Top
Abstract
Materials and Methods
Results
Discussion
3D"References
&nb= sp;

  1. Chang CH, Horton J, Schoenfeld D, et al. Comparison of=20 postoperative radiotherapy and combined postoperative radiotherapy and = chemotherapy in the multidisciplinary management of malignant gliomas. = A Joint=20 Radiation Therapy Oncology Group and Eastern Cooperative Oncology = Group Study.=20 Cancer 1983;52:997=961007.3.0.CO;2-2&= ;link_type=3DDOI">[CrossRef][Medline]
  2. Laperriere N, Zuraw L, Cairncross G. Radiotherapy for = newly=20 diagnosed malignant glioma in adults: a systematic review. Radiother = Oncol=20 2002;64:259=9673.[CrossRef][Medline]
  3. Jallo GI, Biser-Rohrbaugh A, Freed D. Brainstem gliomas. = Childs=20 Nerv Syst 2004;20:143=9653.[CrossRef][Medline]
  4. Broniscer A, Gajjar A. Supratentorial high-grade = astrocytomas and=20 diffuse brainstem glioma: two challenges for the pediatric oncologist. = Oncologist 2004;9:197=96206.[Abstract/Free Full Text]
  5. Stupp R, Mason WP, van den Bent MJ, et al. European = organization=20 for research and treatment of cancer brain tumor and radiotherapy = groups:=20 National Cancer Institute of Canada Clinical Trials Group. = Radiotherapy plus=20 concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med=20 2005;352:987=9696.[Abstract/Free Full Text]
  6. Zagzag D, Armirnovin R, Greco MA, et al. Vascular = apoptosis and=20 evolution in gliomas precede neovascularization: a novel concept for = glioma=20 growth and angiogenesis. Lab Invest 2000;80:837=9649.[Medline]
  7. Zagzag D, Miller DC, Chiriboga L, et al. Green = fluorescent protein=20 immunohistochemistry as a novel experimental tool for the detection of = glioma=20 cell invasion in vivo. Brain Pathol 2003;13:34=967.[Medline]
  8. Newcomb EW, Lymberis SC, Lukyanov Y, et al. Radiation = sensitivity=20 of GL261 murine glioma model and enhanced radiation response by = flavopiridol.=20 Cell Cycle 2005;5:93=969.
  9. Zagzag D, Salnikow K, Chiriboga L, et al. Downregulation = of major=20 histocompatibility complex antigens in invading glioma cells: stealth = invasion=20 of the brain. Lab Invest 2005;85:328=9641.[CrossRef][Medline]
  10. Burnet FM. The concept of immunological surveillance. = Prog Exp=20 Tumor Res 1970;13:1=9627.[Medline]
  11. Schreiber H, Wu TH, Nachman J, et al. Immunodominance = and tumor=20 escape. Semin Cancer Biol 2002;12:25=9631.[CrossRef][Medline]
  12. Cabrera T, Lopez-Nevot MA, Gaforio JJ, et al. Analysis = of HLA=20 expression in human tumor tissues. Cancer Immunol Immunother = 2003;52:1=969.[Medline]
  13. Bubenik J. Tumour MHC class I down-regulation: tumour = escape from=20 immune surveillance? Int J Oncol 2004;25:487=9691.[Medline]
  14. Dunn GP, Old LJ, Schreiber RD. The immunobiology of = cancer=20 immunosurveillance and immunoediting. Immunity 2004;21:137=9648.[CrossRef][Medline]
  15. Emens LA, Jaffee EM. Leveraging the activity of tumor = vaccines=20 with cytotoxic chemotherapy. Cancer Res 2005;65:8059=9664.[Abstract/Free Full Text]
  16. Pure E, Allison P, Schreiber RD. Breaking down the = barriers to=20 cancer immunotherapy. Nat Immunol 2005;6:1207=9610.[CrossRef][Medline]
  17. Garnett CT, Palena C, Chakraborty M, et al. Sublethal = irradiation=20 of human tumor cells modulates phenotype resulting in enhanced killing = by=20 cytotoxic T lymphocytes. Cancer Res 2004;64:7985=9694.[Abstract/Free Full Text]
  18. Klein B, Loven D, Lurie H, et al. The effect of = irradiation on=20 expression of HLA class I antigens in human brain tumors in culture. J = Neurosurg 1991;80:1074=967.
  19. Santin AD, Hiserodt JC, Fruehauf J, et al. Effects of = irradiation=20 on the expression of surface antigens in ovarian cancer. Gynecol Oncol = 1996;60:468=9674.[CrossRef][Medline]
  20. Ogawa Y, Nishioka A, Hamada N, et al. Expression of fas = (CD95/APO-1) antigen induced by radiation therapy for diffuse B-cell = lymphoma:=20 immunohistochemical study. Clin Cancer Res 1997;3:2211=966.[Abstract]
  21. Olschowka JA, Kyrkanides S, Harvey BK, et al. ICAM-1 = induction in=20 the mouse CNS following irradiation. Brain Behav Immun = 1997;11:273=9685.[CrossRef][Medline]
  22. Herrlinger U, Kramm CM, Johnston KM, et al. Vaccination = for=20 experimental gliomas using GM-CSF-transduced glioma cells. Cancer Gene = Ther=20 1997;4:345=9652.[Medline]
  23. Campanella M, Sciorati C, Tarozzo G, et al. Flow = cytometric=20 analysis of inflammatory cells in ischemic rat brain. Stroke = 2002;33:586=9692.[Abstract/Free Full Text]
  24. Newcomb EW, Tamasdan C, Entzminger Y, et al. = Flavopiridol=20 inhibits the growth of GL261 gliomas in vivo: implications for=20 malignant glioma therapy. Cell Cycle 2004;3:230=964.[Medline]
  25. Williams A, Au Peh C, Elliott T. The cell biology of = MHC class I=20 antigen presentation. Tissue Antigens 2002;59:3=9617.[CrossRef]<= A=20 = href=3D"http://clincancerres.aacrjournals.org/cgi/external_ref?access_num= =3D11972873&link_type=3DMED">[Medline]
  26. Insug O, Ku G, Ertl HCJ, et al. A dendritic vaccine = induces=20 protective immunity to intracranial growth of glioma. Anticancer Res=20 2002;22:613=9622.[Medline]
  27. Demaria S, Kawashima N, Yang AM, et al. Immune-mediated = inhibition of metastases following treatment with local radiation and=20 CTLA-4-blockade in a mouse model of breast cancer. Clin Cancer Res=20 2005;85:328=9641.
  28. Friedman EJ. Immune modulation by ionizing radiation = and its=20 implications for cancer immunotherapy. Curr Pharm Des = 2002;8:1765=9680.[CrossRef][Medline]
  29. McBride WH, Chiang C-S, Olson JL, et al. A sense of = danger from=20 radiation. Radiat Res 2004;162:1=9619.[CrossRef][Medline]
  30. Demaria S, Bhardwaj N, McBride WH, et al. Combining = radiotherapy=20 with immunotherapy: a revived partnership. Int J Radiat Oncol Biol = Phys=20 2005;63:655=9666.[CrossRef][Medline]
  31. Lumniczky K, Desaknai S, Mangel L, et al. Local tumor = irradiation=20 augments the antitumor effect of cytokine-producing autologous cancer = cell=20 vaccines in a murine glioma model. Cancer Gene Ther = 2002;9:44=9652.[CrossRef][Medline]
  32. Hu B, Guo P, Fang Q, et al. Angiopoietin-2 induces = human glioma=20 invasion through the activation of matrix metalloprotease-2. Proc Natl = Acad=20 Sci U S A 2003;100:8904=969.[Abstract/Free Full Text]
  33. Weiss WA, Israel M, Cobbs C, et al. Neuropathology of = genetically=20 engineered mice: consensus report and recommendations from an = international=20 forum. Oncogene 2002;21:7453=9663.[CrossRef][Medline]
  34. Cha S, Johnson G, Wadghiri YZ, et al. Dynamic, = contrast-enhanced=20 perfusion MRI in mouse gliomas: correlation with histopathology. Magn = Reson=20 Med 2003;49:848=9655.[CrossRef][Medline]
  35. Sampson JH, Archer GE, Ashley DM, et al. Subcutaneous = vaccination=20 with irradiated, cytokine-producing tumor cells stimulates CD8+ = cell-mediated=20 immunity against tumors located in the "immunologically privileged" = central=20 nervous system. Proc Natl Acad Sci U S A 1996;93:10399=96404.[Abstract/Free Full Text]
  36. Hickey W. Basic principles of immunological = surveillance of the=20 normal central nervous system. Glia 2001;36:118=9624.[CrossRef][Medline]
  37. Prins RM, Liau LL. Cellular immunity and immunotherapy = of brain=20 tumors. Front Biosci 2004;9:3124=9636.[Medline]
  38. Dranoff G, Jaffee E, Lazenby A, et al. Vaccination with = irradiated tumor cells engineered to secrete murine = granulocyte-macrophage=20 colony-stimulating factor stimulates potent, specific, and = long-lasting=20 anti-tumor immunity. Proc Natl Acad Sci U S A 1993;90:3539=9643.[Abstract/Free Full Text]
  39. Dranoff G. GM-CSF-based cancer vaccines. Immunol Rev=20 2002;188:147=9654.[CrossRef][Medline]
  40. Hauser SH, Calorini L, Wazer DE, et al. = Radiation-enhanced=20 expression of major histocompatibility complex class I antigen H-2Db = in B16=20 melanoma cells. Cancer Res 1991;53:1952=965.
  41. Prins RM, Odesa SK, Liau LM. Immunotherapeutic = targeting of=20 shared melanoma-associated antigens in a murine glioma model. Cancer = Res=20 2003;63:8487=9691.[Abstract/Free Full Text]
  42. Steiner HH, Bonsanto MM, Beckhove P, et al. Antitumor = vaccination=20 of patients with glioblastoma multiforme: a pilot study to assess = feasibility,=20 safety, and clinical benefit. J Clin Oncol 2004;22:4272=9681.[Abstract/Free Full Text]
  43. Fine HA. Toward a glioblastoma vaccine: promise and = potential=20 pitfalls. J Clin Oncol 2004;22:4240=963.[Free Full Text]
  44. Plautz GE, Miller DW, Barnett GH, et al. T cell = adoptive=20 immunotherapy of newly diagnosed gliomas. Clin Cancer Res = 2000;6:2209=9618.[Abstract/Free Full Text]
  45. Okada H, Lieberman FS, Edington HD, et al. Autologous = glioma cell=20 vaccine admixed with interleukin-4 gene transfected fibroblasts in the = treatment of recurrent glioblastoma: preliminary observations in a = patient=20 with a favorable response to therapy. J Neurooncol = 2003;64:13=9620.[CrossRef][Medline]
  46. Liau LM, Prins RM, Kiertscher SM, et al. Dendritic cell = vaccination in glioblastoma patients induces systemic and intracranial = T-cell=20 responses modulated by the local central nervous system tumor=20 microenvironment. Clin Cancer Res 2005;11:5515=9625.[Abstract/Free Full Text]
  47. Rutowski S, De Vleeschouwer S, Kaempgen E, et al. = Surgery and=20 adjuvant dendritic cell-based tumour vaccination for patients with = relapsed=20 malignant glioma, a feasibility study. Br J Cancer = 2004;91:1656=9662.[Medline]
  48. Yu JS, Liu G, Ying H, et al. Vaccination with tumor = lysate-pulsed=20 dendritic cells elicits antigen-specific, cytotoxic T-cells in = patients with=20 malignant glioma. Cancer Res 2004;64:4973=969.[Abstract/Free Full Text]
  49. Al-Batran S-E, Rafiyan M-R, Atmaca A, et al. = Intratumoral T-cell=20 infiltrates and MHC class I expression in patients with stage IV = melanoma.=20 Cancer Res 2005;65:3937=9641.[Abstract/Free Full Text]
  50. Hald J, Rasmussen N, Claesson MH. In vivo = infiltration of=20 mononuclear cells in squamous cell carcinoma of the head and neck = correlates=20 with the ability to expand tumour-infiltrating T cells in vitro = and=20 with the expression of MHC class I antigens on tumour cells. Cancer = Immunol=20 Immunother 1994;39:383=9690.[CrossRef][Medline]



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Cancer=20 Epidemiology Biomarkers & Prevention Molecular=20 Cancer Therapeutics
Molecular=20 Cancer Research Cell Growth=20 & Differentiation
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XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_0000_01C87561.37926E40 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://clincancerres.aacrjournals.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= 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quoted-printable Content-Location: http://clincancerres.aacrjournals.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. 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// set the web path to the __utm.gif file=0A= var _utsp=3D"|"; // transaction field separator=0A= var _uflash=3D1; // set flash version detect option (1=3Don|0=3Doff)=0A= var _utitle=3D1; // set the document title detect option = (1=3Don|0=3Doff)=0A= var _ulink=3D0; // enable linker functionality (1=3Don|0=3Doff)=0A= var _uanchor=3D0; // enable use of anchors for campaign = (1=3Don|0=3Doff)=0A= var _utcp=3D"/"; // the cookie path for tracking=0A= var _usample=3D100; // The sampling % of visitors to track (1-100).=0A= =0A= //-- UTM Campaign Tracking Settings=0A= var _uctm=3D1; // set campaign tracking module (1=3Don|0=3Doff)=0A= var _ucto=3D"15768000"; // set timeout in seconds (6 month default)=0A= var _uccn=3D"utm_campaign"; // name=0A= var _ucmd=3D"utm_medium"; // medium (cpc|cpm|link|email|organic)=0A= var _ucsr=3D"utm_source"; // source=0A= var _uctr=3D"utm_term"; // term/keyword=0A= var _ucct=3D"utm_content"; // content=0A= var _ucid=3D"utm_id"; // id number=0A= var _ucno=3D"utm_nooverride"; 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path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= } else if (a>=3D0 && b>=3D0 && c>=3D0) {=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= } else {=0A= if (a>=3D0) a=3D_uFixA(_ubd.cookie,";",_ust);=0A= else a=3D_udh+"."+_uu+"."+_ust+"."+_ust+"."+_ust+".1";=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= }=0A= if (_ulink && xx && xx!=3D"" && xx!=3D"-") {=0A= xx=3D_uUES(xx);=0A= if (xx.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmx=3D"+xx+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= if (_ulink && v && v!=3D"" && v!=3D"-") {=0A= v=3D_uUES(v);=0A= if (v.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmv=3D"+v+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= _uInfo(page);=0A= _ufns=3D0;=0A= _ufno=3D0;=0A= if (!page || page=3D=3D"") _uff=3D1;=0A= }=0A= function _uInfo(page) {=0A= var p,s=3D"",dm=3D"",pg=3D_udl.pathname+_udl.search;=0A= if (page && page!=3D"") pg=3D_uES(page,1);=0A= _ur=3D_ubd.referrer;=0A= if (!_ur || _ur=3D=3D"") { _ur=3D"-"; 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