From: Subject: Nature Clinical Practice Neurology | Therapy Insight: clinical management of pregnant women with epilepsy | Article Date: Tue, 13 May 2008 16:09:56 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C8B513.C8FF74D0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/ncpneuro/journal/v2/n4/full/ncpneuro0153.html;jsessionid=0EC2D738E8D2A49FA478A770574AC95D Nature Clinical = Practice Neurology | Therapy Insight: clinical management of pregnant = women with epilepsy | Article

Login

3D"Nature =
= = Advanced search=20
Home > Archive=20 > Vol 2 = No 4=20 > Revie= w > Full = Text

Review

3D"ContinuingNature Clinical Practice Neurology (2006) = 2,=20 190-200
doi:10.1038/ncpneuro0153=20  3D""=20
Received 2 = August 2005 |=20 Accepted 7 February 2006

Therapy Insight: clinical management of pregnant women with = epilepsy

Alison M Pack  About=20 the author

Correspondence Neurological Institute, 710 = West 168th=20 Street, New York, NY 10032, USA

Email ap390@columbia.edu

Summary

In pregnant women with epilepsy who are being treated = with=20 antiepileptic drugs (AEDs), careful clinical management is vital because = seizure=20 frequency can change during pregnancy, and both seizure activity and AED = treatment can have consequences for the developing fetus. Complications = of=20 epilepsy and AED treatment include stillbirths, prematurity, low birth = weight,=20 major and minor malformations, and cognitive delay later in life. = Certain AEDs=20 probably have more adverse effects than others; data from prospective = studies=20 indicate that phenobarbital and valproate are associated with = significant=20 increases in major malformations, and retrospective studies show lower = verbal=20 IQs and greater need for extra assistance in school for children whose = mothers=20 received valproate during pregnancy. Monitoring of AED levels and dosage = adjustment are warranted throughout pregnancy, and vitamin K1 = at a=20 dose of 10 mg/day should be given in the last month, particularly when=20 cytochrome P450 enzyme-inducing AEDs are being administered. In the = postpartum=20 period, breastfeeding is recommended; however, there is differential = transfer of=20 individual AEDs in breast milk, and the infant should be observed = clinically.=20 For all women of reproductive age, preconceptual counseling is = important, and=20 includes optimization of the AED regimen and advising the mother to take = supplemental folic acid.

Review criteria

PubMed was searched using Entrez for articles published = up to=20 December 15 2005, including electronic early release publications. = Search terms=20 included "epilepsy" or "antiepileptic drug", as well as "pregnancy", = "registry",=20 "neurocognitive" or "breastfeeding". The abstracts of retrieved = citations were=20 reviewed and prioritized by relative content. Full articles were = obtained and=20 references checked for additional material when appropriate.

Keywords:

antiepileptic=20 drugs, breastfeeding,=20 epilepsy=20 malformations, pregnancy

Top of page

Introduction

Pregnancy is associated with dynamic changes in the = body, and for=20 women with epilepsy who are undergoing treatment with antiepileptic = drugs (AEDs)=20 there are unique management concerns. This review highlights how seizure = frequency can change during pregnancy, and the potential effects of = epilepsy and=20 AEDs on the developing fetus, illustrated by results from both = retrospective and=20 prospective studies. This article also discusses specific management = issues for=20 women with epilepsy during pregnancy, including preconceptual = counseling,=20 monitoring of AED levels and vitamin K prophylaxis, and recommendations = with=20 regard to breastfeeding.

Top of page

Seizure frequency during pregnancy

Seizure frequency can increase or decrease in an = unpredictable=20 manner during pregnancy, and the nature of the change is not related to = seizure=20 type, duration, or seizures in previous pregnancies. Changes in seizure=20 frequency are thought to be secondary to multiple factors, including = alterations=20 in the concentration and type of circulating steroid hormones during = pregnancy,=20 changes in maternal physiology that result in alterations in the=20 pharmacokinetics of prescribed AEDs, and poor compliance with the drug = regimen=20 if the mother fears potential teratogenesis from AED use.

In the nonpregnant state, the main circulating estrogens = in the=20 body are estradiol and estrone. In pregnancy, the concentrations of both = of=20 these estrogens increase, and levels of estriol=97a peripheral = metabolite of=20 estrone and estradiol=97show an even more marked increase. Progesterone = production=20 also increases dramatically. These hormonal changes might have direct=20 consequences on the presentation of seizures, as it has been suggested = that=20 estrogen has proconvulsant properties, whereas progesterone has = antiepileptic=20 effects.1

Top of page

Preconceptual counseling

Women with epilepsy need to plan their pregnancies = carefully, as=20 changes in AED regimens might be beneficial. Ideally, women should be = prescribed=20 the most effective and best-tolerated AED regimen at the lowest possible = dose=20 before becoming pregnant. Changing medication once pregnant is not = always=20 practical=97lamotrigine therapy, for example, cannot be initiated = quickly=97and=20 might subject the mother and developing fetus to additional risks as a = secondary=20 consequence of seizures. If possible, women on polytherapy should be = switched to=20 monotherapy, as data indicate that polytherapy is associated with a = higher risk=20 of teratogenic abnormalities. If a woman has not had a seizure in 2 = years or=20 more, tapering off medication can be an option.

Because folic acid fortification in cereal grains has=20 significantly decreased the rates of neural tube defects in the US and = Canada,=20 the American Academy of Neurology recommends that all women of = childbearing age=20 take folic acid supplementation at a dose of 0.8=964.0 mg/day. No = definitive proof=20 exists, however, that folic acid has protective effects in children = whose=20 mothers take AEDs.2=20 Possible explanations for the lack of effect include an inability to = overcome=20 AED-related teratogenic mechanisms, or inadequate doses.

Top of page

Epilepsy, antiepileptic drugs and the developing fetus

Controlling seizures during pregnancy is vital, as = seizures are=20 likely to have an adverse effect on the developing fetus. Generalized=20 TONIC=96CLONIC SEIZURES might cause hypoxia, leading to damage of the = CNS as well=20 as of other organ systems, and sustained hypoxia can result in fetal = death. In a=20 study of pregnant rats, induction of seizures resulted in neuronal = damage in=20 numerous regions of the fetal CNS, including the hippocampus.3=20 In addition to hypoxia, a generalized tonic=96clonic seizure could = result in=20 trauma to the mother or fetus. Maternal death rates might also be higher = in=20 women with epilepsy.4

The effect of partial seizures on the developing fetus = is not=20 clear. In one case report,5=20 a 33-year-old pregnant woman had a complex partial seizure during labor, = and=20 intrauterine pressure catheter and fetal heart monitoring during the = seizure=20 revealed a strong, prolonged uterine contraction and a simultaneous = significant=20 fetal heart rate deceleration for 3.5 min. Another report6=20 documented fetal heart rate deceleration during a complex partial = seizure in the=20 fetus of a 43-year-old woman in her seventh month of pregnancy. These = findings=20 indicate that the fetus might be affected during complex partial = seizures, and=20 it is advised that complex partial seizures are controlled throughout = pregnancy.=20 Recent studies also indicate that generalized tonic=96clonic seizures = might result=20 in cognitive problems for the child later in life, a phenomenon that is=20 supported by evidence of significantly decreased verbal IQ scores in = children=20 whose mothers had more-frequent generalized tonic=96clonic seizures = during=20 pregnancy.4,=20 7

Older studies indicate that perinatal complications are = more=20 prevalent in women with epilepsy.8,=20 9=20 Possible complications include stillbirth, prematurity and low birth = weight, and=20 stillbirths have even been reported to occur after a single seizure. = STATUS=20 EPILEPTICUS carries an increased risk of these complications. A recent=20 historical population-based cohort study in Iceland,10=20 however, found no significant difference in perinatal mortality and mean = birth=20 weight in offspring of women with epilepsy, as compared with the general = population. The risk of perinatal complications has not been studied=20 prospectively.

The most common and worrying adverse effects for = pregnant women=20 with epilepsy relate to the potential teratogenesis of AEDs. Teratogenic = effects=20 are classified as either major malformations or minor anomalies, and = both have=20 been associated with maternal AED use. A major malformation is an = abnormality=20 that is present at birth and interferes significantly with life = function, and=20 which can require surgical intervention. Possible major malformations = include=20 congenital heart disease, urogenital defects, cleft lip or palate, and = neural=20 tube defects. Minor anomalies include facial dysmorphism and digital = anomalies;=20 these anomalies are typically subtle and are often outgrown.

Factors such as maternal epilepsy have been argued to = contribute=20 to the increased risk of defects; indeed, some early studies concluded = that the=20 mother's epilepsy itself was the teratogen.11,=20 12=20 Little evidence remains, however, that seizures themselves result in = increased=20 teratogenicity, and recent studies indicate that potential for = teratogenesis is=20 a consequence of AED treatment and not epilepsy per se.13=20 Early retrospective studies identified a higher risk of malformations = and=20 anomalies associated with AED use.8,=20 14,=20 15=20 These studies included mothers who took the older AEDs; that is, those = drugs=20 approved before 1993 (phenobarbital, phenytoin, carbamazepine, = primidone,=20 valproic acid and trimethadione). The risk increased further in mothers = who were=20 receiving polytherapy.15=20 It is important to use prospective studies to identify the risk of=20 malformations, as studies of this nature eliminate potential biases, = such as=20 selection and recall bias.

A recent cross-sectional controlled study13=20 of 922 infants=97316 of whom who were exposed to AEDs through treatment = of the=20 mother for seizures, 98 of whom were not exposed to AEDs but whose = mothers had a=20 history of epilepsy, and 508 of whom were not exposed to AEDs and whose = mothers=20 had no history of epilepsy=97uncovered a pattern of physical = abnormalities=20 associated with AED use but not with maternal epilepsy. No significant=20 differences in outcome were seen between infants whose mothers had a = history of=20 seizures but were not treated with AEDs during pregnancy and infants of = mothers=20 with no history of epilepsy. Infants of mothers with a history of = epilepsy who=20 received AEDs during pregnancy had a higher frequency of major = malformations,=20 including microcephaly, growth retardation, and hypoplasia of the = mid-face and=20 fingers, than did infants whose mothers had no history of epilepsy or = had a=20 history of epilepsy but did not receive AEDs. Children born to mothers = who took=20 multiple AEDs showed the highest frequency of malformations.

A population-based study of over 20,000 patients with = epilepsy=20 identified 939 births among 561 untreated patients and 1,411 births = among 857=20 patients using AEDs in the first trimester.16=20 In this study, valproate use was associated with excess risk of = congenital=20 malformations (monotherapy: odds ratio [OR] 4.18; 95% CI 2.31=967.57; = polytherapy:=20 OR 3.54; 95% CI 1.42=968.11) compared with the offspring of untreated = patients.=20 The risk of congenital malformations did not increase in the offspring = of=20 mothers using carbamazepine, oxcarbazepine or phenytoin (as monotherapy = or=20 polytherapy without valproate).

Pregnancy registries for major malformations

To ascertain the frequency of major malformations = associated=20 with prenatal exposure to AEDs, pregnancy registries have been = established.=20 There are two different types of registry: hospital-based and=20 pharmaceutical-based. The first hospital-based registry to be = established was=20 the North American AED Pregnancy Registry. Other hospital-based = registries=20 include the Australian Pregnancy Registry of Women Taking Antiepileptic = Drugs,=20 the UK Epilepsy and Pregnancy Register, and the European and = International=20 Registry of Antiepileptic Drugs and Pregnancy (EURAP), which includes = countries=20 throughout Europe and Asia. Several pharmaceutical-based registries are = also=20 actively enrolling subjects.

The North American AED Pregnancy Registry was first = established in=20 1997. Eligible women must enroll themselves, and are interviewed three = times: at=20 enrollment, at 7 months' gestation, and postpartum (8=9612 weeks after = the=20 expected delivery).17=20 Enrolled women are divided into pure prospective cases (no information = about=20 fetus known) and traditional prospective cases (some knowledge of status = of=20 fetus known). For analysis only pure prospective cases are used, to = reduce=20 potential bias. Positive association is released when the lower end of = the=20 confidence interval for the proportion of major malformations is 2.0 or = higher.=20 Controls are infants with malformations who are registered by the Active = Malformations Surveillance Program at Brigham and Women's Hospital, and = the=20 baseline rate of major malformations is 1.62% after exclusion of infants = with=20 genetic disorders and chromosome abnormalities (conditions also excluded = from=20 the major malformations considered in the AED registry). In addition, = the=20 prevalence of malformations found in specific AED-exposed groups is = compared=20 with the prevalence of malformations among infants of women exposed to = all other=20 AEDs (internal comparison group). The internal comparison group is = similar to=20 the studied groups in terms of demographics and prenatal = exposures.17,=20 18

Using this methodology, it was calculated that 6.5% of = 77 infants=20 exposed to phenobarbital (95% CI 2.1%=9614.5%) were born with major=20 malformations.17=20 Specific malformations of infants exposed to phenobarbital from this = registry=20 are described in Box=20 1. When compared with the external comparison group (control = population),=20 the relative risk of having an affected infant after exposure to = phenobarbital=20 was 4.2 (95% CI 1.5=969.4). At the time of publication, the internal = comparison=20 group consists of 796 infants exposed to three other AEDs, and the = prevalence of=20 malformations in this group is 2.9% (95% CI 1.8=964.3%). Comparison of = the two=20 groups yielded a relative risk of 2.0 (95% CI 0.9=964.5).17

Box 1 Malformations reported in children exposed to = phenobarbital=20 (North American Antiepileptic Drug Pregnancy Registry).17

 

Cardiac malformations

  COARCTATION of the aorta with abnormal = valves

  Ventricular septal defect

  TETRALOGY OF FALLOT

  Pulmonary atresia

 

Cleft lip and palate

Of 149 infants exposed to valproate monotherapy, 10.7% = (95% CI=20 6.3=9616.9%) had major malformations.18 <= A=20 href=3D"http://www.nature.com/ncpneuro/journal/v2/n4/full/ncpneuro0153.ht= ml;jsessionid=3D0EC2D738E8D2A49FA478A770574AC95D#bx3">Box=20 2 outlines malformations found in valproate-exposed infants from = this=20 registry. The relative risk of having an affected infant when compared = with the=20 external comparison group is 7.3 (95% CI 4.4=9612.2). The internal = comparison=20 group at the time of this analysis consisted of 1,048 women exposed to = all other=20 AEDs as monotherapies. The prevalence of malformations in the internal=20 comparison group was 2.9% (95% CI 2.0=964.1%), and the odds ratio when = comparing=20 the valproate-exposed group with this group was 4.0 (95% CI 2.1=967.4; = P=20 <0.001).18

Box 2 Malformations reported in children exposed to = valproate=20 (North American Antiepileptic Drug Pregnancy Registry).18

 

Nervous system malformations

  Spina bifida

  SUTURE SYNOSTOSIS

 

Cardiopulmonary malformations

  Tetralogy of Fallot

  Atrial septal defect

  Ventricular septal defect

  Bicuspid aortic valve

  Pulmonary atresia

 

Renal malformations

  HYPOSPADIAS

  Multicystic dysplastic kidneys

 

Limb malformations

  POLYDACTYLY

  Club foot

 

Developmental delay

 

Inguinal hernia

The Australian Pregnancy Registry of Women Taking = Antiepileptic=20 Drugs, which was established in 1999, is a prospective, voluntary,=20 telephone-based registry that enrolls three groups of pregnant women: = those with=20 epilepsy taking AEDs; those with epilepsy not taking AEDs; and those = taking AEDs=20 for a nonepileptic indication.19,=20 20,=20 21,=20 22=20 The third group is important, as AEDs are being prescribed increasingly = for=20 multiple indications, including pain, bipolar depression, anxiety and = headaches.=20 The pregnancy outcomes are evaluated by follow-up interviews and by = reference to=20 hospital and treating doctors' records. To date, 493 pregnancies have = been=20 completed including nine sets of twins, giving a total of 502 pregnancy=20 outcomes. The fetal malformation rate was greater in fetuses exposed to=20 valproate in the first trimester than in those exposed to all other AEDs = (15.2%=20 vs 2.4%, OR 7.40, 95% CI 3.12=9617.5) or no AEDs (17.1% vs 2.5%, OR = 9.96, 95% CI=20 1.26=9638.5). The incidence of fetal malformations was significantly = lower in=20 those taking valproate doses of 1,400 mg or less per day than in those = taking=20 doses of more than 1,400 mg per day (34.5% vs 5.5%, OR 0.109, 95% CI=20 0.0405=960.295).20,=20 21,=20 22

The UK Epilepsy and Pregnancy Register is a prospective=20 observational registry and, as in the North American and Australian = registries,=20 the outcome is not known before enrollment. AED use is not mandatory. = Enrollment=20 is either by self-referral or by a healthcare practitioner, and data are = obtained 3 months after expected delivery. Full outcome data are = currently=20 available on 3,607 cases.23=20 The overall major congenital malformation rate was 4.2% (95% CI = 3.6=965.0%);=20 therefore, almost 96% of live births born to women with epilepsy did not = have a=20 major congenital malformation. The malformation rate was higher for = pregnancies=20 exposed to polytherapy (6.0%, n =3D 770) than for monotherapy = exposure=20 (3.7%, n =3D 2,598). Valproate exposure resulted in the highest=20 malformation rate, and carbamazepine exposure was associated with the = lowest=20 malformation rate. Table=20 1 outlines malformation rates for individual AEDs, comparing these = drugs=20 with carbamazepine exposure using an OR, and Table=20 2 provides information on specific types of major congenital = malformation,=20 listed by AED. Interestingly, this study revealed higher percentages of=20 malformations in association with higher doses of carbamazepine, = valproate and=20 lamotrigine, although this finding was statistically significant only = for=20 lamotrigine.23,=20 24

Table=20 1 Major congenital malformation rate by monotherapy = antiepileptic drug=20 exposure (UK Epilepsy and Pregnancy Register).23

Full=20 tableFigures=20 & Tables indexDownload=20 Power Point slide (163K)

Table=20 2 Types of major congenital malformation listed by = antiepileptic drug=20 (UK Epilepsy and Pregnancy Register).23

Full=20 tableFigures=20 & Tables indexDownload=20 Power Point slide (141K)

EURAP is an international registry of AEDs and = pregnancy, and=20 includes countries in Europe, Asia, Oceania and South America. Women are = enrolled by physicians to a central registry. Women taking AEDs for any=20 indication at the time of conception are included. Like other = registries, only=20 individuals registered without prior knowledge of fetal outcome are = eligible for=20 inclusion in analyses, and data are collected until 1 year after = delivery. Since=20 June 2004, more than 2,000 prospective cases have been enrolled and have = completed assessment.25=20 Of those enrolled, 81% took a single AED, 16% took two different AEDs, = and 2%=20 took three or more AEDs. Overall, the current malformation rate is 6% = (5% for=20 monotherapy cases and 8% for polytherapy cases). To date, no formal = comparison=20 between AEDs has been made, because there is currently insufficient = statistical=20 power in the final analysis to allow inclusion of multiple risk factors = that=20 might confound the result.

Several pharmaceutical companies have established = registries, most=20 within the past 2 years. Data are available in a peer-reviewed = publication for=20 the GlaxoSmithKline-sponsored International Lamotrigine Pregnancy=20 Registry.26=20 Pregnant women with unknown outcomes from their pregnancies were = enrolled=20 between September 1992 and March 2004. Findings were compared with those = from=20 the Centers for Disease Control and Prevention (CDC) Metropolitan = Atlanta=20 Congenital Defects Program. These databases are similar in many = respects,=20 because they use the same criteria. The CDC program, however, follows = children=20 up to 1 year of age, whereas the lamotrigine registry collects = information only=20 up to birth, thereby perhaps underestimating the comparative risk, as = some=20 malformations only become evident as the child gets older. In the latter = registry, among 414 first-trimester exposures to lamotrigine = monotherapy, 12=20 major malformations were reported, giving a malformation rate of 2.9% = (95% CI=20 1.6=965.1%). Among those exposed to polytherapy including lamotrigine = the=20 malformation rate was 12.5% (95% CI 6.7=9621.7%) for regimens including = valproate,=20 and 2.7% (95% CI 1.0=966.6%) for regimens that did not include = valproate. Box=20 3 presents a list of the malformations that were reported from this=20 registry. The authors conclude that the monotherapy findings are similar = to=20 those reported by the CDC's Metropolitan Congenital Defects Program = (2=963%), and=20 that there was no specific trend found regarding malformations in = association=20 with lamotrigine treatment.26=20 The sample size, however, might have limited the ability to detect = specific=20 increases.

Box 3 Malformations reported in children exposed to = lamotrigine=20 (International Lamotrigine Pregnancy Registry).26

 

Nervous system malformations

  Anencephaly

  Lumbar neural tube defect

  MYELOMENINGOCELE

  MENINGOMYELOCELE

  Microcephaly

 

Cardiopulmonary malformations

  Atrial septal wall defect

  Ventricular septal defect

  Transposition of great arteries

  PATENT FORAMEN OVALE

  PATENT DUCTUS ARTERIOSUS

  Pulmonary stenosis

 

Renal malformations

  HYDRONEPHROSIS

  Absent kidney

 

Cleft palate

 

Limb malformations

  Club foot

  Polydactyly

  Limb deformities

 

Atresia of anus

 

Bilateral talipes

 

PYLOROSTENOSIS

As discussed, prospective data are available on many = AEDs,=20 including carbamazepine, phenytoin, valproate, lamotrigine and = phenobarbital.=20 Prospective data are limited for other AEDs (sample sizes <50). It is = important to differentiate data ascertained from monotherapy and = polytherapy=20 studies, as polytherapy is consistently associated with a higher risk of = teratogenesis. Retrospective and prospective studies indicate an = increased risk=20 of malformations in association with phenytoin, phenobarbital and = valproate=20 monotherapies, and the risk is higher for polytherapy exposure. Multiple = studies=20 have shown that of these three drugs, valproate therapy carries the = highest=20 risk.

Retrospective studies indicate an increased risk of = teratogenesis=20 secondary to carbamazepine exposure. A meta-analysis of 795 children = exposed to=20 carbamazepine monotherapy revealed that 5.28% had a major congenital=20 malformation (cardiovascular abnormalities, urinary tract anomalies, = cleft=20 palate or neural tube defects), compared with 2.34% of 3,756 control=20 children.27=20 Other studies have also identified an increased incidence of neural tube = defects=20 in children exposed to carbamazepine.28,=20 29=20 Prospective studies published more recently, however, have not found a=20 significantly elevated risk of major malformations in = carbamazepine-exposed=20 children.23

Retrospective studies have been conducted in children = exposed to=20 oxcarbazepine, gabapentin, levetiracetam and zonisamide. A review of all = published studies of oxcarbazepine-exposed children found that 6 of 248 = children=20 (2.4%) exposed to oxcarbazepine monotherapy had major malformations, and = 4 of 61=20 children (6.6%) exposed to oxcarbazepine in combination with another AED = had=20 major malformations.30=20 Among 48 gabapentin-exposed pregnancies in 39 women, two babies, both of = whom=20 were exposed to gabapentin in combination with other AEDs, had major=20 malformations.31=20 No abnormalities were reported in a case series of three babies whose = mothers=20 received levetiracetam in monotherapy throughout pregnancy.32=20 Of 26 children whose mothers took zonisamide with or without other AEDs, = malformations were detected in two, both of whom were exposed to = zonisamide=20 polytherapy.33=20 Further prospective well-controlled studies are needed to fully define = and=20 differentiate the potential teratogenesis of these AEDs as given in=20 monotherapy.

Minor malformations

Minor anomalies have been shown to occur in = association with=20 all AEDs.34=20 Midline craniofacial anomalies, including OCULAR HYPERTELORISM, broad = nasal=20 bridge, short upturned nose, altered lips and epicanthal folds, in = addition to=20 distal digital and nail hypoplasia, are among the minor anomalies that = have been=20 described in children of mothers with epilepsy who took AEDs during = pregnancy.=20 These features can be difficult to recognize, and the child might = outgrow them.=20 The presence of these anomalies, however, can be associated with = developmental=20 and cognitive delay later in life.35=20 Seventy-six children whose mothers took AEDs in pregnancy were included = in a=20 systematic study of physical features and intelligence testing, as = determined by=20 the Wechsler Intelligence Scale for Children=AE (Harcourt = Assessment=20 Inc., San Antonio, TX). Mid-face or digital hypoplasia correlated = significantly=20 with deficits in verbal IQ, performance IQ and full-scale IQ. = Interestingly,=20 there was no decrease in IQ in association with major = malformations.35

Cognitive deficits

Understanding the effects of epilepsy and AED = exposure=20 during pregnancy on developmental and cognitive outcome has become the = focus of=20 recent retrospective and prospective studies. In addition to teratogenic = malformations, AED exposure in utero might have adverse effects = on=20 cognitive development. Studies of cognitive function in children whose = mothers=20 took AEDs during pregnancy suggest poorer cognitive development as = defined by=20 multiple parameters, including lower IQ scores, and specific cognitive = deficits=20 in visuospatial functioning, spelling and linguistic abilities.4,=20 7,=20 36,=20 37,=20 38,=20 39=20 It is difficult to determine long-term effects from the early studies, = however,=20 as these predominantly studied young children. More-recent studies have=20 evaluated older children, and have confirmed the presence of longer term = cognitive deficits in some individuals.4

Interestingly, a differential effect of individual AEDs = has been=20 identified in retrospective and prospective studies of young and older = children=20 who were exposed to AEDs in utero. Phenobarbital exposure = resulted in a=20 7-point reduction in verbal IQ in adult men who had been exposed to=20 phenobarbital during gestation, compared with controls whose mothers did = not=20 take AEDs during pregnancy.38=20 In retrospective studies, valproate use is associated with lower verbal = IQ=20 scores and additional educational needs, as defined by attendance in = special=20 schools and extra assistance in school. Other factors that contributed = to this=20 cognitive impairment included mother's IQ and number of tonic=96clonic = seizures=20 during pregnancy.4,=20 7,=20 37=20 A prospective study of 86 children exposed to carbamazepine monotherapy = in=20 utero did not find any differences between this group and control = subjects=20 in verbal and nonverbal IQ scores, whereas children exposed to = polytherapy or to=20 valproate in utero had significantly reduced verbal = intelligence.36=20 The authors were not able to separate the independent effects of = polytherapy and=20 valproate exposure, as valproate was usually a component of the = polytherapy=20 regimen. Lower than expected IQ scores were also found in children = exposed to=20 valproate monotherapy in utero in a prospective population-based=20 study.39=20 The mothers treated with valproate in this study, however, had lower=20 intelligence and schooling level, which could have influenced the = findings.

A large-scale international study, Neurodevelopmental = Effects of=20 Antiepileptic Drugs (NEAD), is currently underway to prospectively = follow=20 children exposed to single AEDs in pregnancy. Children will be followed = through=20 to 6 years of age, and the AEDs being studied include valproate, = phenytoin,=20 carbamazepine and lamotrigine. Preliminary data indicate that valproate = is=20 associated with significantly more adverse outcomes, including fetal = death,=20 major congenital malformations and developmental delay, than the other = AEDs=20 under investigation.40

Top of page

Management of women with epilepsy during pregnancy

Once pregnant, a woman with epilepsy who is being = treated with=20 AEDs should be followed by an obstetrician who is comfortable with her = medical=20 condition and treatment. A high-risk obstetrician or maternal fetal = medicine=20 specialist is preferable, although this might not always be possible. = Pregnant=20 women should have first-trimester serologic and ultrasonographic studies = to=20 assess the risk of neural tube defects.41,=20 42=20 A level II or anatomic ultrasound performed between weeks 16 and 20 will = provide=20 a detailed view of the fetus. Amniocentesis is not always necessary, = although=20 amniotic ALPHA-FETOPROTEIN analysis might provide an additional = assessment of=20 the risk of neural tube defects.

During pregnancy, the monitoring of AED levels will help = to=20 maintain seizure control. AED pharmacokinetics are affected by the = physiological=20 changes of pregnancy. During pregnancy, renal blood flow and glomerular=20 filtration increase as a function of increased cardiac output, and = plasma=20 volume, extravascular fluid and adipose tissue increase to create a = larger=20 volume of distribution. The level of serum albumin decreases, which = reduces drug=20 binding, increases the free fraction and increases drug clearance. These = pharmacokinetic alterations can affect AED concentrations, and are most=20 important for AEDs that are highly protein-bound, hepatically = metabolized or=20 renally cleared. Both total and free levels of highly protein-bound = AEDs,=20 including phenytoin and valproate, should be monitored.

Lamotrigine metabolism and clearance increases during = pregnancy,=20 and understanding the effect of pregnancy on lamotrigine concentrations = is=20 particularly important as this drug is being used increasingly in women = who are=20 considering pregnancy. In a prospective study of 14 women, lamotrigine=20 concentrations were followed before conception and monthly throughout = the=20 pregnancy.43=20 Lamotrigine clearance increased until 32 weeks' gestation, reaching a = peak of=20 >330% of baseline, and the clearance began to decline thereafter. A=20 retrospective study of 11 women found a significant decrease in the = ratio of=20 plasma lamotrigine concentration : dose, of 65.1% in the second = trimester, and=20 65.8% during the third trimester, compared with pre-pregnancy = values.44=20 Clinically, five patients experienced increased seizure frequency, = probably a=20 result of decreased concentrations of lamotrigine. Women treated with = AEDs=20 during pregnancy should have their drug levels monitored throughout = pregnancy,=20 and have their doses adjusted accordingly. The frequency of monitoring = depends=20 on the particular AED, with more-frequent monitoring being required for=20 lamotrigine.

Vitamin K prophylaxis is recommended in the last few = weeks of=20 pregnancy, starting at approximately week 36. The incidence of = hemorrhagic=20 disease in the newborn child has been reported to be increased in = infants=20 exposed to AEDs during pregnancy=97in particular, AEDs that induce the = CYTOCHROME=20 P450 ENZYME SYSTEM. Cytochrome P450 enzyme-inducing AEDs, including=20 phenobarbital, primidone, phenytoin, carbamazepine and, to a lesser = extent,=20 oxcarbazepine and topiramate, induce fetal microsomal enzymes, which = degrade=20 vitamin K. In addition, these drugs might cause competitive inhibition = of the=20 addition of calcium-binding -car= boxyglutamic-acid=20 residues to the precursors of clotting factors II, VII, IX and X. = Bleeding in=20 AED-exposed infants typically occurs early, and includes = intra-abdominal,=20 intracranial and intrathoracic locations.

Interestingly, 204 infants who were exposed to = cytochrome P450=20 enzyme-inducing AEDs, and whose mothers, with the exception of one, did = not take=20 antenatal vitamin K, had no significant increase in hemorrhage compared = with a=20 control group.45=20 Similarly, a prospective study of over 600 pregnant women treated with=20 cytochrome P450 enzyme-inducing AEDs, including phenytoin, = carbamazepine,=20 phenobarbital, primidone and oxcarbazepine, did not find a statistically = significant elevation of bleeding complications.46=20 A logistic regression analysis did not find bleeding complications to be = associated with exposure to cytochrome P450 enzyme-inducing AEDs. The=20 researchers concluded, however, that administration of vitamin = K1=20 might still be needed in selected cases.47=20 It is recommended, therefore, that women who are taking AEDs=97and in = particular=20 cytochrome P450 enzyme-inducing AEDs=97should take vitamin K1 = 10 mg/day=20 orally during the last month of pregnancy, followed by a single dose of = 1 mg=20 given intramuscularly or intravenously to the newborn.

Top of page

Breastfeeding

Breastfeeding a newborn baby has many advantages, = including=20 maternal transfer of antibodies, as well as promoting bonding between = mother and=20 child. In addition, for many women, breastfeeding is an integral and = important=20 part of the experience of motherhood. Given these considerations, the = American=20 Academy of Neurology and the American Academy of Pediatrics advise that = women=20 with epilepsy taking AEDs can breastfeed.48=20 During breastfeeding the baby will, however, continue to be exposed to = the AED=20 in varying concentrations depending on the prescribed AED. If mothers = receiving=20 ethosuximide, phenobarbital or primidone choose to breastfeed, they = should=20 exercise caution and closely monitor the infant for sedation, lethargy = and any=20 significant clinical findings.49=20 On the basis of small studies, including single-dose studies, case = reports and=20 short-term studies, phenytoin, carbamazepine and valproate are probably = safe.=20 These AEDs are all moderately to highly protein-bound, and are not = transferred=20 in high concentrations in breast milk. A small study of four infants = indicates=20 that lamotrigine might be transferred to the infant through breast milk = in=20 concentrations similar to those seen in the mother, as lamotrigine is=20 extensively metabolized by glucuronidation, which is immature in = infants.50=20 Given these findings, infants who are breastfed by mothers receiving = lamotrigine=20 should be monitored.

In eight women receiving levetiracetam, concentrations = of the drug=20 were approximately equal in milk and plasma.51=20 In their babies, however, levels of levetiracetam in the serum were very = low,=20 indicating extensive transfer in milk and rapid elimination of = levetiracetam in=20 infants. Similarly, 2=963 weeks after delivery in five mother=96child = pairs in which=20 the mother was treated with topiramate, the mean milk : maternal plasma=20 concentration ratio of topiramate was 0.86,52=20 yet topiramate concentrations of the drug in the infants were very low,=20 indicating efficient elimination by the infant. It should be noted, = however,=20 that in this small study four of the five mothers were also taking=20 carbamazepine, which induces metabolism of topiramate, as well as = inducing fetal=20 metabolism in general (including metabolism of carbamazepine). The=20 pharmacokinetics of gabapentin during lactation was studied in six=20 infants.53=20 The milk : maternal plasma concentration ratio was 1.0 (range 0.7=961.3) = from 2=20 weeks to 3 months. Plasma concentrations were low in suckling infants, = however,=20 and no adverse effects were reported. Studies also indicate that = oxcarbazepine=20 and zonisamide are transferred extensively in breast milk.

In summary, breastfeeding is a viable option for women = with=20 epilepsy who are being treated with AEDs. Caution and clinical = monitoring should=20 be exercised if the mother is using phenobarbital, primidone, = ethosuximide or=20 lamotrigine. Larger scale studies are needed to better understand drug = transfer=20 in breast milk and metabolism in infants for all AEDs.

Top of page

Conclusion

Careful management of pregnant women with epilepsy who = are being=20 treated with AEDs is important, as seizure frequency can change during=20 pregnancy, and both seizure activity and AED drug treatment might have=20 consequences for the developing fetus, including increased rates of = stillbirth,=20 teratogenesis and cognitive delay. Some AEDs probably have more adverse = effects=20 than others. In addition, drug-level monitoring and dosage adjustment = throughout=20 pregnancy is warranted. Vitamin K1 at a dose of 10 mg/day = should be=20 given in the last month of pregnancy, particularly in women who are = taking=20 cytochrome P450 enzyme-inducing AEDs. Breastfeeding is generally = recommended,=20 although there is differential transfer of individual AEDs in breast = milk, and=20 the infant should be observed clinically. For all women with epilepsy of = reproductive age, preconceptual counseling is important. Such counseling = should=20 include optimization of the AED regimen, and advising the women to take=20 supplemental folic acid.

Issues that need to be addressed in further studies = include better=20 differentiation of which AEDs result in higher rates of major = malformations,=20 defining cognitive effects of in utero AED exposure, and = establishing=20 better guidelines for breastfeeding. The pregnancy registries discussed = are=20 likely to better define potential teratogenicity of individual AEDs, = especially=20 of the newer AEDs where information is lacking. The NEAD study will = define=20 prospectively the potential cognitive effects of the studied AEDs = (phenytoin,=20 carbamazepine, valproate and lamotrigine). Further studies are needed, = however,=20 to address cognitive effects of other AEDs; particularly if these agents = are=20 used in increasing numbers during pregnancy.

Top of page

References

  1. Foldvary-Schaefer N et = al. (2004) Hormones and=20 seizures. Cleve Clin J Med = 71 (Suppl 2): S11=96S18
  2. Pennell P (2005) Using current = evidence in=20 selecting antiepilepsy drugs for use during pregnancy. Epilepsy Curr 5:=20 45=9651 | PubMed |
  3. Hallak M et al. (1999) Fetal rat brain = damage=20 caused by maternal seizure activity: prevention by magnesium = sulfate.=20 Am J Obstet Gynecol 181: 828=96834 | Article = ;| PubMed | ISI | = ;ChemPort |
  4. Adab N et al. (2004) The longer term = outcome of=20 children born to mothers with epilepsy. J=20 Neurol Neurosurg Psychiatry 75:=20 1575=961583 | Article |&nb= sp;PubMed | ISI | = ;ChemPort |
  5. Nei M et al. (1998) A maternal = complex partial=20 seizure in labor can affect fetal heart rate. Neurology 51:=20 904=96906 | PubMed | ISI | = ;ChemPort |
  6. Sahoo S and Klein P (2005) Maternal = complex partial=20 seizure associated with fetal distress. Arch=20 Neurol 62: = 1304=961305 | Article |&= nbsp;PubMed | ISI |
  7. Vinten J et al. (2005) Neuropsychological effects=20 of exposure to anticonvulsant medication in utero. Neurology 64:=20 949=96954 | PubMed | ISI | = ;ChemPort |
  8. Speidel BD and Meadow SR (1972) Maternal = epilepsy and=20 abnormalities of the fetus and newborn. Lancet 2:=20 839=96843 | PubMed | ISI | = ;ChemPort |
  9. Bjerkedal T and Bahna SL (1973) The course and = outcome of=20 pregnancy in women with epilepsy. Acta Obstet=20 Gynecol Scand 52:=20 245=96248 | PubMed | ISI | = ;ChemPort |
  10. Olafsson E et al. = (1998) Pregnancies of = women with=20 epilepsy: a population-based study in Iceland. Epilepsia 39:=20 887=96892 | Article=  | PubMed | ISI | = ;ChemPort |
  11. Monson RR et al. = (1973) Diphenylhydantoin and=20 selected congenital malformations. N = Engl J=20 Med 289: = 1049=961052 | PubMed | ISI | = ;ChemPort |
  12. Hanson JW et al. = (1976) Risks to the = offspring of=20 women treated with hydantoin anticonvulsants, with emphasis on the = fetal=20 hydantoin syndrome. J Pediatr = 89: 662=96668 | PubMed | ISI | = ;ChemPort |
  13. Holmes LB et al. = (2001) The = teratogenicity of=20 anticonvulsant drugs. N Engl J = Med 344: 1132=961138 | Article |=  PubMed | ISI | = ;ChemPort |
  14. Lindhout D et al. = (1992) Antiepileptic = drugs and=20 teratogenesis in two consecutive cohorts: changes in prescription = policy=20 paralleled by changes in pattern of malformations. Neurology 42 (Suppl=20 5): S94=96S110
  15. Nakane Y (1979) Congenital = malformation=20 among infants of epileptic mothers treated during pregnancy=97the = report of a=20 collaborative study group in Japan. Folia=20 Psychiatr Neurol Jpn 33:=20 363=96369 | PubMed | ChemPort |
  16. Artama M et al. (2005) Antiepileptic = drug use of=20 women with epilepsy and congenital malformations in offspring. = Neurology 64:=20 1874=961878 | PubMed | ISI | = ;ChemPort |
  17. Holmes LB et al. = (2004) The AED = (antiepileptic=20 drug) pregnancy registry: a 6-year experience. Arch Neurol 61:=20 673=96678 | Article |&n= bsp;PubMed | ISI |
  18. Wyszynski DF et al. = (2005) Increased rate = of major=20 malformations in offspring exposed to valproate during = pregnancy. Neurology 64:=20 961=96965 | PubMed | ISI | = ;ChemPort |
  19. Vajda FJ et al. (2003) The Australian = registry of=20 anti-epileptic drugs in pregnancy: experience after 30 months. = J Clin Neurosci 10:=20 543=96549 | Article = ;| PubMed | ISI | = ;ChemPort |
  20. Vajda FJ et al. (2004) Critical = relationship=20 between sodium valproate dose and human teratogenicity: results of the = Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 11:=20 854=96858 | Article |&= nbsp;PubMed | ISI | = ;ChemPort |
  21. Vajda F et al. (2004) Australian = pregnancy=20 registry of women taking antiepileptic drugs. Epilepsia 45:=20 1466 | Article&= nbsp;| PubMed | ISI |
  22. Vajda FJ and Eadie MJ (2005) Maternal = valproate dosage=20 and foetal malformations. Acta Neurol = Scand 112: = 137=96143 | Article&n= bsp;| PubMed | ISI | = ;ChemPort |
  23. Morrow JI et al. = (2005) Malformation = risks of=20 anti-epileptic drugs in pregnancy: a prospective study from the UK = Epilepsy=20 and Pregnancy Register. J Neurol = Neurosurg=20 Psychiatry 77: = 193=96198 | PubMed | ISI |
  24. Russell AJ et al. = (2004) U.K. epilepsy = and pregnancy=20 group. Epilepsia 45: 1467 | Article&= nbsp;| PubMed | ISI |
  25. Tomson T et al. (2004) EURAP: an = international=20 registry of antiepileptic drugs and pregnancy. Epilepsia 45:=20 1463=961464 | Article&= nbsp;| PubMed | ISI |
  26. Cunnington M and Tennis P = (2005) Lamotrigine and = the risk of=20 malformations in pregnancy. Neurology=20 64: 955=96960 | PubMed | ISI | = ;ChemPort |
  27. Matalon S et al. = (2002) The teratogenic = effect of=20 carbamazepine: a meta-analysis of 1255 exposures. Reprod Toxicol 16:=20 9=9617 | Article = ;| PubMed | ISI | = ;ChemPort |
  28. Rosa FW (1991) Spina bifida in = infants of=20 women treated with carbamazepine during pregnancy. N Engl J Med 324:=20 674=96677 | PubMed | ISI | = ;ChemPort |
  29. Hernandez-Diaz S et = al. (2001) Neural tube = defects in=20 relation to use of folic acid antagonists during pregnancy. = Am J Epidemiol 153:=20 961=96968 | Article | = ;PubMed | ISI | = ;ChemPort |
  30. Montouris G (2005) Safety of the = newer=20 antiepileptic drug oxcarbazepine during pregnancy. Curr Med Res Opin 21: 693=96701 | Article |&nbs= p;PubMed | ISI | = ;ChemPort |
  31. Montouris G (2003) Gabapentin = exposure in=20 human pregnancy: results from the Gabapentin Pregnancy = Registry. Epilepsy Behav 4:=20 310=96317 | Article = ;| PubMed | ISI |
  32. Long L (2003) Levetiracetam = monotherapy=20 during pregnancy: a case series. Epilepsy=20 Behav 4: = 447=96448 | Article = ;| PubMed | ISI |
  33. Kondo T et al. (1996) Preliminary = report on=20 teratogenic effects of zonisamide in the offspring of treated women = with=20 epilepsy. Epilepsia 37: 1242=961244 | Article=  | PubMed | ISI | = ;ChemPort |
  34. Pennell PB (2003) The importance = of=20 monotherapy in pregnancy. Neurology=20 60 (Suppl 4): = S31=96S38 | Article |
  35. Holmes LB et al. = (2005) The correlation = of deficits=20 in IQ with midface and digit hypoplasia in children exposed in = utero to=20 anticonvulsant drugs. J = Pediatr 146: 118=96122 | PubMed | ISI | = ;ChemPort |
  36. Gaily E et al. (2004) Normal = intelligence in=20 children with prenatal exposure to carbamazepine. Neurology 62:=20 28=9632 | PubMed | ISI | = ;ChemPort |
  37. Adab N et al. (2001) Additional = educational=20 needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 70: 15=9621 | Article | <= A=20 class=3Dreftxt=20 title=3D"Article on PubMed - Additional educational needs in children = born to mothers with epilepsy"=20 = href=3D"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=3Dnpg&c= md=3DRetrieve&db=3DPubMed&list_uids=3D11118242&dopt=3DAbstrac= t">PubMed | ISI | = ;ChemPort |
  38. Reinisch JM et al. = (1995) In utero = exposure to=20 phenobarbital and intelligence deficits in adult men. JAMA 274:=20 1518=961525 | Article |&nb= sp;PubMed | ISI | = ;ChemPort |
  39. Eriksson K et al. = (2005) Children = exposed to=20 valproate in utero=97population based evaluation of risks and = confounding=20 factors for long-term neurocognitive development. Epilepsy Res 65:=20 189=96200 | Article&n= bsp;| PubMed | ISI | = ;ChemPort |
  40. Meador K et al. (2005) Differential = and dose=20 dependent effects of in utero antiepileptic drugs [abstract=20 #427]. Neurology 64 (Suppl 1): aS62.002
  41. Bahado-Singh RO and = Sutton-Riley J (2004) Biochemical = screening for=20 congenital defects. Obstet Gynecol = Clin North=20 Am 31: = 857=96872 | PubMed | ISI |
  42. Fong KW et al. (2004) Detection of = fetal=20 structural abnormalities with US during early pregnancy. Radiographics 24:=20 157=96174 | PubMed | ISI |
  43. Pennell PB et al. = (2004) The impact of = pregnancy and=20 childbirth on the metabolism of lamotrigine. Neurology 62:=20 292=96295 | PubMed | ISI | = ;ChemPort |
  44. Petrenaite V et al. = (2005) Individual = changes in=20 lamotrigine plasma concentrations during pregnancy. Epilepsy Res 65:=20 185=96188 | Article&n= bsp;| PubMed | ISI | = ;ChemPort |
  45. Choulika S et al. = (2004) Is antenatal = vitamin K=20 prophylaxis needed for pregnant women taking anticonvulsants? = Am J Obstet Gynecol 190: 882=96883 | Article |&= nbsp;PubMed | ISI | = ;ChemPort |
  46. Kaaja E et al. (2002) Enzyme-inducing = antiepileptic drugs in pregnancy and the risk of bleeding in the=20 neonate. Neurology 58: 549=96553 | PubMed | ISI | = ;ChemPort |
  47. Astedt B (1995) Antenatal drugs = affecting=20 vitamin K status of the fetus and the newborn. Semin Thromb Hemost 21: 364=96370 | PubMed | ISI | = ;ChemPort |
  48. [No authors listed] (1998) Practice = parameter:=20 management issues for women with epilepsy (summary statement). Report = of the=20 Quality Standards Subcommittee of the American Academy of = Neurology.=20 Epilepsia 39:=20 1226=961231 | Article=  |
  49. Pennell PB (2003) Antiepileptic = drug=20 pharmacokinetics during pregnancy and lactation. Neurology 61 (Suppl=20 2): S35=96S42
  50. Liporace J et al. = (2004) Concerns = regarding=20 lamotrigine and breast-feeding. Epilepsy=20 Behav 5: = 102=96105 | Article |=  PubMed | ISI |
  51. Johannessen SI et al. = (2005) Levetiracetam=20 concentrations in serum and in breast milk at birth and during=20 lactation. Epilepsia 46: 775=96777 | Article&n= bsp;| PubMed | ISI | = ;ChemPort |
  52. Ohman I et al. (2002) Topiramate = kinetics during=20 delivery, lactation, and in the neonate: preliminary = observations.=20 Epilepsia 43:=20 1157=961160 | Article&n= bsp;| PubMed | ISI |
  53. Ohman I et al. (2005) Pharmacokinetics of=20 gabapentin during delivery, in the neonatal period, and lactation: = does a=20 fetal accumulation occur during pregnancy? Epilepsia 46:=20 1621=961624 | Article&n= bsp;| PubMed | ISI |
    54. =
Top of page
Competing interests

The author declared no competing interests.

Top of page

Contact=20 the journal about this article

Subject areas under which this article = appears: Epilepsy

MORE ARTICLES LIKE THIS

These links to content published by NPG are = automatically=20 generated.

NEWS AND VIEWS

Seizing hold = of=20 seizures

Nature Medicine News and Views (01 Aug=20 2003)

RESEARCH

Tiagabine= =20 Synergistically Interacts with Gabapentin in the Electroconvulsive = Threshold=20 Test in Mice

Neuropsychopharmacology Original = Article

Pharmacol= ogical=20 and Behavioral Characteristics of Interactions between Vigabatrin and=20 Conventional Antiepileptic Drugs in Pentylenetetrazole-Induced Seizures = in Mice:=20 An Isobolographic Analysis

Neuropsychopharmacology Original = Article

See all 10 matches for Research

Extra navigation

.

ARTICLE NAVIGATION -ARTICLE TOOLS

Main navigation

  • Home
  • = Advance=20 Online Publication
    • About= =20 AOP
  • Current = issue
  • Archive
    • Issues
    • Subjec= ts
    • Authors=
    • CME = articles
  • About = the=20 journal
    • Top Ten=20 articles
    • Aim= s=20 & scope
    • Publishing = &=20 editorial policies
    • Instructions=20 for Authors
    • = Facts=20 & figures
    • Commercia= l=20 opportunities
    • Information=20 for librarians
    • Contact=20 the journal
  • Help
  • Reprints and=20 permissions

Resources

Top

Nature Clinical Practice Neurology

ISSN: 1745-834X

EISSN: 1745-8358

------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/ncpneuro/images/print_journal_logo.gif R0lGODlhUAFKAPf/AOFkseV8vbGwsOydzvj4+OXl5T46O4qIiPvq9O2l0nh1du+t1vr6+umOxvTG 4/32+9xNpmViYtg6nJ6dnV1aW+FptLm4uPzu9vCy2Pne79rZ2evr66alpcLBwZqYmcbFxuJsteqS yOeFwfLy8u6q1ExISd5VqvbS6fXL5eV6vNk+nu2i0PPC4PT09OR2u9Qmkv75/PDw8OaCwOfm56qo qOPj4/ja7PK63Ozs7K6srfG12tUqlPzy+ffX65aUlNYultpCoOuazUhFRr69vfzx+P74/GBdXra0 td9drt7e3tHQ0dtGouBhsOno6Prl8jg1NtYslTUxMt1SqPK+3u/v79g3moiGhqOhoXRyctcymNzc 3NbW1lFOTlhVVvvt9nx6emxqauqWyo6MjNYvl358ffnj8UVBQtc0mfPA4Prm8nJwcN5ZrJKQkbCu ryYiI19cXS0qKkE+PpSSk3l3d1RRUvXN5uNxuNg4m5COjoB+ftpEoZuZmoaEhSklJoKAgDAsLd1Q p2dlZWtoaXBtbttJpISBgiMfIOqVyvK83f39/eiLxf/9/srJytQlkcvKy+iKxPjd7tUok/f39+qU yfnh8FdUVENAQHZzdPb29s3MzPzv9/30+UtHSFNQUdXU1L27vOiIw95Yq6mnqPfY7P78/n57fP78 /Xd0ddLR0lJPUNYtlbi3t+6o0+Lh4fbP5+Nwt3JvcPG42/ro8/z7/P31+vG53Do3OFtYWeiJxPz8 /PTJ5NDPz9tHo/jb7UdERdtFovTH45iWl7Szs9bV1aimp+jn529sbWJfYPfU6dzb2/jZ7OV4u6yr q+Fns/K93vb19crJyczLy09MTYWDhPvp9M7NzfXO5ouJiu+w1+Df4NjX2Lu6uvbQ59TT0/nf7+3t 7dxLpG1ra6GfoEZCQ/rk8TMvME1KS+Z/v+Bgr+uXy6SioumPx8/OzpmXmNPS0uRzueHg4JGPkPfV 6lZTVMjHx+yfz9pAn+Bfr8nIyGpnaI2LjCsnKPPD4aCen9Qkkf///yH5BAEAAP8ALAAAAABQAUoA AAj/AP8JHEiwoMGDCBMqXMiwocOHECNKnEixosWLGDNq3DhQAD2OIEOKHEmypMmTKBEqcSMmpcuX MGPKnEkzmSVDbWjq3Mmzp8+F/RgNnDFEnLoOVBSimoBl0KkDFmIYxGfAkCELBAkwIDCjxgiFBBAS aOdJYA0a7ToUxNSBjTFjc0TVgNiNwzQwhWi4MzgD3sICc/+1cPdMISYNDMwWO5gkx7Vwpa44Yqhh BkINXyEmSuKos2dGuywT5MzIsyPQrRIpTKSkBcMmq+LBUrCnQ1iBkqqV9ryL3W5H0Hb9S7LhYDJm B8Dk4RDNICZUpqMzan5wxBdDV/49u1bVqiEhOQ5m/4rQpxKeaeWsmtNAkNgf70LeULhVQog0LgZs kRmIic8xChEEUok0wRiEgyDY/ZODLd55INAsHHBiSCXxsBGIIU/4kAtDwwTiCyz9CLBHOHGE49dA +hizkB9zCFRNHwooNAwXoinQEkFNnCJEIMEIcIUCvlBA3UE4PGHELAeZM0REBFAghBFQRtkFF4Eo MVAEBkQJ5RtGpFLJHqodhI8bchh2jTQUxNOGKIVwwoUAAs2QDwVaGhCHlhSE808EExRUgxpC5NPj FVhY8gYqBHXzRBda4nmMmFxYJcwGqXhnqRvMFJQDHIYUKNAu+1gVgUBUXGhpOULc8sYb5rjhHR23 zf/ywQSwWBpIQav4IikzlmIoSRMRGALHNgRt04chsEii0DblHJAUjpcYwJ5AVtyq0BdYCARNFHGE h1A3QhQgEBYHEJSMAWC0UlALbETxCUKizMMFOweNQyxEknBxRCL89jtLK378odY/twTTr79UiBIH LLcVpEYEFGRm0Dd0VGIlQYmI8oSD/xzMLxbTeKwaBZ4K5I4tWIg20AgHPDHwP9EI0YTIBxPEQAfG HGtVKZ0Y8YEG2rDxnlV/qHyEqyoSRIdVBkg1Qg4cPGGVG0Ngwh8H3nXR8JXe6fkPA58EO/UxT4xj qS1JVGKIGy8PpIBV1yT0QRSrJHSAOa79c4AgC5H/cYlAH3DyQRxJIORJCeL+Q+5ArRjQTkJtPKGu QZV04MMXBwnxLr6dYIVQm0hSsEdC2cAhjEHwhHvM6QZJQgcWiR2kxBNLGqRAuQa9wfE/ydjSJ0Ic GJB4Jpzg4FALCnTnXR4FbeOqVXD+s4HUfUxG0C1WPRGYQKa6sUVBmXj3RuwEHdA1qWBIbWkbDIiS niGFqGFVtgaBYVU5iRcUgy+PJ5SIORwQyN769rd/fMASejOC4RA3LtzN4hiwWAgYWlSQD5SAABoo QXEKormISKITdUNIKyxhJdEpxA+DMIgP8vEPDijQIAfgxNYMIocukM9tVjiI7gZyixgpJAJ8EAjx /zZ4PGl4xwAz/EcXvBO3f6jDKuNAEkGWaIhx5E0gYnPDxTrinQIWRA7eKQRBsqE+Q4xKIN0QgwAs 8DwxWE0wMWBEHiwVvYJcwRc3PAgNxqGaASrEb4BDICZSUTKCHC5xi/tHJv6wGIVkwhYqEwgs9qPE AHJwcw/5YAgRIo3wmDAhNKBDQQjgi3cVYxzaKMgMnvCBhVChHJmwXQ5zx7FP2IKICPnAE74yxIhc xyqnOMjbrIK5FsLhCZvkIRSvOIulGWIf+RNIG7wTTIOwwTt4KIjYDNFEgpjKEH3wBR3oYIAo9CpB BZkFBfqnkBZQx48JAaQBEfgPVBigGwY5ZAMFcv+KaiokF9W44j+KYYtp0aALBukg55JpEC7k5JMI mcAZB3IEvAlkEEEkCDPM0ZBu4FIgCphlQXb4j0v4UCGSUILVegmRUninTAYphHdK8aBqRHIgQljm QBgQKWEJ9B/TBOZBrmmVGw0EC94hRkEKwKm1iYEGHCDGBMTABh/IwW/X2N5AcBCFaTkEngiR5wEH EoxUzFCfiitXLqRBg4lMgAIDaYIZykIQhWYShAlJQhxSCdGDdEGp3sTdPzrAiTcKJByClUhIdeig Z3DiXg7JRAm+4UvviOIgHpjpQoags3FIjKdWgYPEpEnNoXpHHw7zjiUHsg345LEhwzAAZR8C1oP/ iJWeHaNARgeC1sU1wRzVkAgDpHHZgQyCeXXFpEM+CNn6UWBkvzuIOOjwLIEkAW0DIcA4lCuNnFBk sbT8RxOecKLIcqIABEivetMriQ0Z5JeGaKtB9qBZhMxgGk01hAx32lPRFiSohvAnQYhqCB+k1iqr FcgEvCON0TpkFZ0wbENqa5DbEqQGBmglbxmY1n8MgxM3bUgH4lDdwVpitgKx63I7kYMYuNjFI/hG NAJhhsm9IasFyHGOa0APMQhCq/8QwwsHImSCmKFtEQHvSB2UhCeguCGoKEcXjrGqKle5uQOBr3wL Qt+dHWQGB4jCG6ahs0rYrL8OBrCAB0Jg7w5E/34ILkgwvGOLJkjEAhGGCIULYmGCiMIMEuttubZw Xolg4aQPskQd/6HihhCgEnHoQiUmPekuUOAaRCQbHVLB6U4/gQtDws04Fv2PLRigcAI5ckWUTJAd Ntl4D2GHJTrgCVTY+taoUAKsC6Llg3TZEDQlSAsmEIU/hGcDQzMzf0Ob5tJa0ztuFgicDZHgfyx4 al59iD2lwpAWhGXPBOkzQYzhT0H/YwYl2KJh3jg9LRhkAgjFqXIb4jpxJOHe+EZvQdI0ghe/uAbE iEN2BrKKEhzECPEYSAlYtxACOPgfrB7IDlcJZIS0YKUl4PZDej3f+gpEG5EqqHWTnRU0/9fZBf9p 84GpXZBPWKq4ENlAFJLBkBHAwkrgHoi4B/KNOLDO3AwwR6YYMod7TWAfWJiD0pd+jD58L8XzZsgH o34QCkTXIB2o80DS94WlL50TlriNIIyqkAlksyARF8gOWyCE2i1kDnVj6ca9s2WC/DrYw7kJHOgl EA00dR4EmUF3/EsQACNa59BeebVboTNDdCFMD5nFLa6OEG3IVm98+2MBx2oQCxhgMeZWHAXBEgeh MKASWFDHBFbP+ggJttFSxytD+moQc9yrBhkSB+tXr/snbI4G0mjIGwZOkLT/g6RYKKZCviEEK8nd IRwvyLWBLZBEIAhZBGGjVbwWp8GXWEHeyXz/QYzgHW8dVbXpJP/UYG4QJdBV+iWAPELk8CjMEzCQ YR3VFjicSGiU46OdVwJfgQ9R8FMUZQCFwWhUh1KytxC0VxCB8DvXAFcIoQDWUgBPAA0LAQ+2kA2y xFgC4Xm7hhDCwAkb8nwNAV/ERxDXsDwCUQDvA1MCAV9vQBCSYERrIxwEIQDeEQWTMxDaZxUyKBD2 YxXsJxCt5R1wcAQHIQwGgCgTEweUp0oGMDA5JxA7J2xCQAOtwH8ORAH0IxbSwDHhoHwGMQIGwIQK 6EENqBAPSBAR0A/aIQRDJx7aIxCFIA1JRBDhEIbFJ1KtxjG5QAeUhBCYIASAhYIMsU3dRBDw/0VB 2uAdFCBFQzA0GKINIxAMcUNFhpAHUtQbWtB4ncAIxbABGhAMT1BGoycQFOAd6nAQc3ApX0APNYAD rfABgtAHdYh1UYBk2dUFXnSF/5CFBMEIipYKiCRY57KCfAYr/1ADtiAUCZEHz8VobrdiDIUQb3gl bPAPFmALBkgQ5tA/LWAOyHUQV2AL0YRDICgQw/AEu1gQg3AL7kU8T8YQOBAH3sEF9zgC88BgX0EF DGIVgYAcf8ABb3BEOVU3+mAplQAGqfAHbYVUlmInbpCBLiU+4UAsW1BGXWBnBTEC3+QdT2AJUgMH pGYQwhAFPuBgw5AKgWBYB8BCCKEaxEgQPv+AKo2USCYTBwrwUXIiDSDJBtIgRQjxjqkkBFg2EPJn g22YENsoEHOAObq1EBxgCVK0AVxgBNkmGNNgAOr2h+0oEI5gC35wjzUQAXSAYsQDkgfhXgJBD3lQ RlYRB2IgLtXgAyXQK76QVVfQK+UQHkowkGtTXE1AmFA0MN+gfpYSAeoCZ3BwC19AA3swB/kVWoIg B6hWfXJAl94RAanEENDwBuNQCBxwBOqgBgZwADeEB3BgBBQQm7Ipm89QCilkQLbwT/PQByBpDNNQ EEkABmagAFdwBMRQCnEwCBvUAgLHEJUQRHEwDrA5m7F5C2Q3EJKwcA1RCQaWEHIwD9pQDu//hxAb YAtq+A8xkAdxAAYTIAzIIQQUMAwJAQtiZBBd0J0DoQH5YAlfUJwcMAdxcAkltgvlIR/UGZvxJhCf EA85IAAOKgDCIA5iYGeOwAei8KAOSgx4oC5HcAvmcJ8qUwMTcA1X4IEDkQ15YA7mgAUWkIACgQk0 EAjmwAWl8DJ80AU5kARSJAxqgqECkANXcAAmShAFIArGIA0fKga70JQLoQTBcArhMAcc8IMDsQFK AA2MkKVaqqWz0BUC0QJdaRBU4AlSVAONVBAacAVz0Id7EJoCwQCo8FoGsQHupgGZsKV4GqYdowUP xxgASBAjoA0bQHMMoQU3VQA58AXGAAti/xBcClEAZzoaf6oBE6AAfTgBhEoQmOAOp4GnWmo9P7Fc oTqqpFqqpnqqqJqqqrqqrNqqrvqqsBqrsjqrtFqrtnqruJqrurqrvNqrvvqrwJoSGYAGC7ACoHAI rBAL8rCqZcAPJJAAuBACrKAD8gADJFEEPYAGJMAKDQAKK5CsKEAJpLATJDAJh3Cu6IquIYANC2EK rBAC6Rqv57oO1vAP5CCv+Jqv6DoJ6eAEA+EE8Kqv8bquBVEErGCuAnsI3vAAA4CwCZuukxAEtdAD F3ARPXAIgFAF/rCxHOsPWQABoIAMDoEBAfuwhxACdWARGRACUiABjdCxG5sFvHAOrsARTv+ADa/A C1kAsxy7A3dACCAwAHVQsQLxACvgsA8LCQPRAyWLr5MQBgTxCzwLsy+ACArxAEAwtTx7CP/gAFr7 tV8bCwMBDGA7tVIwrgNBBFlbtv5wA5qgCmwLtkvgAg4wEcjwCjsQt5HwCifAEKEQtx27DhTRC8sA t3HbDCiAESiQAncAuB2LBANxARrruBgwEKwQtwQBCGyrBwiQEEUgBXE7AP+AAo5btlYrEHVQuv6A BItAEEQAumzLAkQgAao7tTsQAF7wEDAQAobbsZGgAjs7taqQDtaaEACgukEgEaYQBMHbsY2gAmeg tTsACg9AEd6wDHk7tVUABNGrtRJQvf//oAm067g3MBDYgLkDoQy14AK9O7WvkBCLAAkOQAIgEAk8 GwqsoAu5+wAosACw+7V3oAIqIAFn0L4by65FiwLYgA5luwMyMAUZUBCkIL8LUAHZ27FSQAJ1sAmk IA+I4AL2q7W/CwHjq7UmIAsNgQDHC7MOfAKyYAOswAtaWwGbkBDewAIN0LwmTALAkLsQoQmvwLOR IAPWIAsZsACEoLVIkAYSkQCNy7NnAArA4A0IkAEOAAolzLF3gML/QArcUA96ALZ7uwAOwAMDoQnA MAXpsLYdCwgrkLgGgQLdO7WNULkMoQPt2wzgWxBEAAFfWwGaIBAwQAlf7MccuwIGYQog//C1jZC8 DBELY9CxILDHBNEAXwsKRYsBMqy191C8CZEGhtyxZ8ACBYEATKC1AGDGCoEIL6u1oVDDEuEFSMCz O7AABaEJzaC1EMDFDiEDqOwNB0ENywCzWWADpRzKPCsB1KAQl9ux5+DJBzEAYFsFEcwQQbyxkdAD CSHNWpsOB0EEa3DIB8ECIcyzWRDIDbHIG7sDy3oQyhDJU8sPBFEGyAyziJwQtBDOMBsJdnzL/wuz zQDNibzJU3vPEfEADMyzCXAQDzDLUxsKlJwQD6DOPJsCAl0QQdCxUADHBHECBsyxLyC2CSECHdsM rasQRKACYAsAJ60Q9cCxvADLB4EGrf/Ms5OAENaQvY9wEN6gwx0LAQ+xAhy7BOhsEDDAxjArzx39 A1qrAjJdEItgB1P7DglxAvDMs7iwEBTNwnUrEb7Ms82QEBkwuTwbAA3hAloLAqbAEOfAsZEwBQdB 0lrLBAlBBGG8sWfQCw0h1WBbD3fMsSYQ0QQBDDUNszd9EKTg0DJwEJvwxDy7Bg+xABwrBRc9EAQN s6RcENc8tbWAECQgvNo80tLb1Qgh1zyrCjUbEbVQ2OtcrwmhCF97ugmR0VOrArysEDxA0AhcELLg 2PvctweBCB2b1Q2xDmWbBSKrECzAsRXQ0nFczoa9zRtr1geRxR1bAQ8BDC+wsZCbEJf/3bGZTRBo 8LXncBBOoNI8+74K4Q1zDLNSINgDAdtTOwbA/RAXgNQcy9IKQQ1kDbO/UNRxfMEwa8sO8dkba9AF YdxaS90GQdFV4K8Nwc1gawJFoBCjwLHqjRAZ4Nsde9gH4QovCwBoSxCLYN0cy+AM4Qrb7Q8goBBS O7XhPRCU8NEbiw5xrbWynRCbzbMk8Nre27kQId88zhBfXdAIUQR/a7Zr7RB2vbFca97tLcpMXBBl MMc77RASDraCmxA9gOEKAQn93eEJwQNMzboGUeJamwIPoeIbi90JkeQ8G+MCoQlJPLUmsOQD0dNT KwFTrhCx8LUQUOEHIeQwKwFA7hCy/2Di/qAKEK4QDgDdHasH8P3ndLzQENHW/qAICYHpUyu6BSHU G1sFfc4QWf61kQAMCaEMKy4CXx7mHOvhRu0MzlDfJK7o/qDmiJ69GX4QFaC1cv4PfWzCeC4Qljy1 3b0QCODq2EzaBUHoHWvoEFHqk90QtIDfHasDifzPonzoDuEML0vVCOENVw2zEADNpvC/DRDtGwsF kE7uRIAQTjC5mp4QYK61sA4RaD61uN4QRAAFGzvvCNHrMG4QwW7szs0DS6C1rM4QprDCU4vJg/7j D7EI4KC15Z3OX7vrAsECrM2xYR0RXgC3KG4QRU615TsQKNDKoq7u/nAHDdDuHTvy//86uVeOEPU+ tfcuECRACIAAzAiR7xX9EJrg75muEAIf5wahCd/NsS5QEPzwtazgEAo+tXpQ2c7OsdDuEK5A9DyL 4Aoh7RwLBNz+DynwtZYeERlgAz5s8z6d3wQRABy78A/BzVlACXD/tS/Q2QYR7xtb8wdx8zZ9EF8d 2gcB9DC77wwx9P9u9L5uEJQw7h179gJh2jzL7AqBAabezs0u8Q4RAl/rDA5Btlr7AhwN7AlPxyk7 EpxOtcBNDU+sCnrN8j/gDQgPtiow9v/A9/7g9wYB+NFtEL0OBaMAv7aO+Auh+EWfEEeP2QYh+jz7 A+RQECagtY1ACQ7h0V/b4wZx9Rv/m/UMQQoOD7ONgOoNAQlcz7N+PRDysOI8WwU+LxIZAPkcuww6 f+ISwc0/oNdTwP5TCxB2/g0k6KSKP3+PCC4kCOkgQogIJzH8p0mCPyijKBJcdDEixBQbRWqCglCR yIEVPkJkQVHGSoQBGMryuDISApQMEdyBiRDURkU9JeDMSfCCip5ZlBUliABIT3/nFi6ACmETU6wo XfSsUuafCYRjbGRdOADhj14Dz0FFSIKhQYQKUTrsmY7iIYQZUXbsGTIrSZM5VcJsufAozDOUGOqK 1FOFJrJIe74CKpQo0wyNet7xlrVIKKgAFoKCuobs6YUnGsMMgmw1CNQDzfpDO9CL/x62d9IWfChX JF2YUmScOyfDBYQXeTWK5AvTL1bA/k6iHLyyMEERMHdgoIgBqh4iZKWErgxzaFYWUKtkIMsE6q+F r6A2ix3bTk898v1F0lV/du2B0NiBLXRM4S2unIBjayW9mKvpo+eYim46kar76Lp/FtDsox2w2SiB 78LLyr2eQnmAoqDMu6woELliL6v7egJiofF6oq++01BYrTQDY/tvt4FIYyuIAxNK8KEFP2pwo+ZW irCoCQXrCZiBemlgR4j0QEOkR0IkCwCowIGMoRRXOg+r2WBaj6wAoJqRIEDmw/E0UkBjixUcf1xI EwjYUgWZgeAyci4kk4RoSYqahP+QrCipkxECQs5YaYwGVmQIl/d4IGutnggZc6EyPzqTqXrUexGr FNxcKE4bNyLHG0pilXVWWjOwtDu2JBDRx7OAHAgYLFeSQlNBfdtIwY+aYWXZFUBB4tDlmHwwoidz arRCQz/So0eRhETMC7Je6mkNGFC0LKtSN+ssq1R7smdVqCpIlJcxsrD3Xnzz/YGynIiQDCYZ5tST IW97WuefNHo7siciFyKlAeX2mhYkRkuSTspsI1ohp1A/aoSacMkzV8Ws0lzpB0DZhYqQhfrsiYlE Jc3YH5iLarMnPPPslSJaWO1pB2A0UZjQniZi6IKDEGVI0Yhk+stiXDD2WIQGBoT/CZATRVqBrbGy 4hQm2EY281atoWrEAbLahUk0gtaASopyF1oEHIuzFagoqnpaQOCdKbJGFbbA6UUyYylCNiKjHXZP abknRkjerHpZzS5HYULhnyCg4k4k76Di50uofhJbVLI3QoOtWNKGyumBtsIPXIbIQSGWMJ5lKxQM ZGGqc5j21pk2XxdaZ0EAPCqcocMhSnyhVHeINlHH/QmFLBQ2dKty6/7Z5JeeIChCJAeCjShnrEiE iXxQz8UqM6g2zsp1mOpZKASoflgKJRjEVVN3rHhfyXf/9I0iDwALWzZ0vIUkTyIbGd4LepCTp8AE AmThnQ6kdqGBQKwniBAJNaLn/4+AZcVtMInECcoztr/8ayWsYwqYprSQWLDlcznpRRZ6ggRSZMV/ HwEgr4CHkhP8wFAIbEihELcRbqRjBRfIyQhXUoWsMYV+CDEh9jD4D3nU7SNIQEmNYHIPsthDKFFM H8mwQgoLfWR6WDGFEz9yBycsJANWgwnlUEIE7sHkHRSESg9RMzCRZC5JRByIAv2xPNSY7yNjCB5K QIAQVZQuJT25ju1gYsGNYEpGsINS9O42uoiMiimChEkWOJmTC/CiJwBYxEIIKDKU0EKVMFkGH/XG tx+ixBSWhAoh/2FIRG4kAzJIR/ButpJGbK4oRFgCQrB2wYhcZ4cReSZFUACVSP9cjik9GENPlEkm 9aFkE86ghCmQocWINMIZWCmDzFaSAIp0KSmS1N4sV+ICW/ZuTuIqYVF6IES2+BKYTNmaP8LAEFKu RHRFccVq8JkTF2ZvIETAzS0H6LOVNKwoiEjOSlRwyjKiMCdoeMEY4MnLj4SwKNcsJf8WIg86/i8n m7DnRx7avz7O6Wv9KYrJYCJQIyqvKItoBkL8WIuqkFEkmvQH+jYCDkrOz02fWkiLroaVSfRkoaCE iCg3Ii4O6gAqS9BUUdK1Eqls5JGrbKVIaNqTm+4upzj6mjZzUgSUfsSXNnDnR4IZOxsCjSE1hAra cuIFj4zhfihpJkxmOJAy2LD/JyHYCBHESEKe6lKREMkCOVDSsa7ScxO46ecmXAaTdRYljQJkiDVi GpEX2JUib4VJXIsyTYj4kSykKCpCUoeZoELEl4zpySGKIsgzeGUhMPDiSpDQVpFkByE1y0lNI7Kl 0UAlC4qhSN5g8kmRkAOgHzkoSjS4kjOcaiMY0IwK4vgPsa4SSiqEiAhysozQ5HAjtL1nPmVaH1Og AyJORQkrepkTB2xoJX8lCBEiqAJuEWSKMHnB9UxHxykwxboQ8dBC2gmVPVLEFL1dyQ7qkBOfIkQK tMiJ/j6iCmvgr4Am+N4/FqEfmxhWJCRQMER+wUSUIKCiyLQwQ/hrU7JgAypF/z7NA+xJWawsIqJ6 zckNoGJbhkyYbYDVboYpggYkhSJuKHkAfSHivoUwdSUv0PFCKBG9UNSYIjyIYESyUEWUkJhDmaVI Qf0R4oFQI48rsYpIYHBaiKiCSisd7xtPzLMNI6SWWUkHVA5Wnx7syARkgURfhZsTecIECCAdyAOC sCOVghMqO8DFKDSxCS+cIAB1i8RjUeIKwH2XIkJ+m1IH4oBuwiQA0M0uh2pRlDKHTiSIGO+lCeKK 4PoDywMZ3kcqrMPXQuQMi97TkD/CL6ys9Yv10QQvX9AAFmPFuxEhZA94AhUksEIXkPDGCXQQggJy eCRQNSAvpDBoiNgRfzGCyf8Y2jyQG/T4IyxcSC2C7aSrcCQdClfFb3OSVWyeoxYnyEAvgMEKO/TY ywvhRvRcAGSCJBQi8iPLDTyt7QGQEQXZRggSxpyTWOSahLoV5xTW4W0fy4AE/IjwRnD8abkBIwHv kOyCdjCGMej8I7JliDIuO7OozBQDk8BowVNAggcS5LwwEUG6GeIAMyOEECtAQR0WYKdQHnsktThE XmHSCChAPdsvUC5DXBFpf/BiAChwhQ6mjJA7YPI08oD7SghxCDRwgx/N/QgEzD5nRAygGTRPJwAO gQF6/kMZ4kMvVV1F38LBoLFYF8p7RZKBxidJFQLfiDywHiFThIDz/oCAPDb/Igs7kB4h4nvBKzyL EpayXtS+tk0KhL+ftTUyK6ZOO0R2vx8T7Ioi8lC4oSwukl48HCoSMP1GlBwR+y4X0cqPiAmKPttJ fBAijQAAN7aJ9bQuRBcgkHpEvskQFjg8qGACDiqKOmA/sCkKFmiGjlqQNfi/+vCCdOi6BYkEKQAF FmA+guiB/jOUGygKWmABRBhBEizBEXSA99sIEQgFFgwFp1oEFLgBE5xBGqTBG8CzokAAVmiGX8iC BvSHMwCEc3CFFJytGqzBG3iehSAHDMCFCggFQFgCXuAFW0uUE2gAE1CBmNoBCZACRTiBImQIIpiC IyzDGbwB6aMIZFCEUNDCKoiIhC6UAV3QwPrYBBRogHtYgjPAkkYYAxWQgncggQy4PHFCAzM8Q3oK CAA7 ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/ncpneuro/images/journal_header_v3.gif R0lGODlh2gN9AMQAAJwEa92jyvfp8sZpqKQGcagHdLExh+/V57AIepQDZbpIlq4IeJABYtGGuaAF bqsHdufB25ICZKcYeKglfZsMbJ8TcpcDZ6MNc60Hd5gDaLMZgpYDZrIJe5ECY7MJfP///yH5BAAA AAAALAAAAADaA30AAAX/YNcxIymaJyqOq7qWTBy/8sum82mT5qz2txRN19L5XMXgz4U0so4tYBHF I/KqzyTuSsw6l+Bgt6S0jZNL87aX82LZQOzQ3F7f2tyokUlVW99iX0J0QnJKP1p5WjtPVTJNXYg7 Uo+Ad3N/gEyNYmyBhISOXjhRoqWXhmSbl4E1ZFmiXJ6Rrn2nTmincD5+s6CPvWp9lFBSgrJ1qppl lkNUcVPGnrzRiVOLrGVzOc+Yg97XzH7jV83DxJGH0JbUetqvq4zjg4hN3JCMpndyrvPekPFG2aOR 7AxBf/kmIXRmS1i/VgZTYZtIkJo9PvSEOXyoSJI8TEhS4RtpsFDJbAU7/+2bpygYuWy4IJ40mWtM PYn8tOWE8WplqE0kbXXTiOpPuFo907iBOSwmPoafQoJKN2ma0aQgFS7i56ieOyhGgfmMSfUi0ZdW fp2jmMdrWn8e3enaA3CqXZVnP0U8Zq0nS719ffkFaYzoUzqH4VVVySeg4W0fIyOMg5NuQnGPEet7 W1jyYW5R4aBJfK3pyYfing7Mh3oy2ZqtZqkerSdgQ3Xy8CxUDBey1MFoSTnVPLO4ba20hQN+d/cW cpqSwYWDuTtl3jPWE9UJqTsuxalDtXs2W63z9MESsZbm/dt6+901EyuV+3w28V7xHMMvTkv6cPjz kSNJesvJtFAyglV3j/933P3znWIeSUXecmu9BYOEsZnGSSdA7ZeRZVuZ5xJnBdrVWHPurfIbegX1 Q1p0zJU4Il4msvbZX9SFUlI7Ff3VXYwWUpjWZkFKeNFtsD13XXAGZiUjjPgBJ590AL34jYf8MWcl lDZl19uXB5mnYpYP0nhXelvq1Yxz/jV3GZbnHUUlXAliJx8lHx7I5HYEphlhZuO9Bqd9K+5F30Y4 3gfnjH6RtKSH3qmi45lkCnplpYkumpumDi0FZKYARlUmp266xqhLjpYK3lWspNobRjN5CRhptI6i KpRpovqkRgiOqqRnsCTJ5al6bvWPq/ttiWR+ptSqqX27RhsqlhFQu83/amwS++AM1cLX7ZufdPtt EeOaUe4KESBx7jzfotCtCdXmCu+26KpJ2rp+4GuuDeuqO067IoirxrjlxtvavY8yCal6CnZwrgrV jluovgdSPKu2r6Ilb8CBWMwvcP+2iSWSIedbLzYEYkqqo4fp64LAfY2QLjQlj8zvmtJ6W7C3kKk8 sLkRrBv0tzAT/QLBHB899NEm12s00+ime7LDMPMb8QniBu1w1PuSm/THJwt97tMlay3wu06/3HXA VXPc774FR3w10l+HzXbdUGctMdVb9701xP6cvbTfTvNNdxeD870o0VevrTjX0ok7b9EGWay10xQ3 3vTlX2veuNFk2430/+dUS12v2kTMPbXVY69OR9UEDz3v3f9SDnToTXCOUNFoJ62741vDPvnatpsN Nt6c45u13W5r7nbpot+NtvPsNv+40lDX3jXZQkO//PPLD2223KCHXvf4URufftvg9z2+6oVfjj70 0jPue+zOg569+5Abr3zwhwNa+4InvfRlb27qO18BW8e1xInPfDuTW97iZ7ilRVB8U5OgAy34M//x znsGfKDe2KZB8iHQfRoEYds4yD8JojB2mDOZ4ExIvhC2MIYuTNz65Ce/G2LwhwB8oQ4JiL3BjY6A 6vOcCfnXvCXWsH48JJwRH1hBHmJQiFckHBSJODD2PbF1NfSi3+YHOf/WcZGK/mugFIPoQRKyjnon RGHnbqhF/CUwjBacoRFLl0QrIvB3IgTgHgVJwjx+bo/vS573PIhGPgYSiIr8IhppWMg0OpJ0OUzk IrOIxB3+kIOTtKLSaBjGEDrxkpi8JB83+cdPPhKIq0zkK/0IyVWuj40iBCUWNenCRQpyipXMpd50 18dK0q+ErbSlI2MpS+uVL4WzrOIjgxnLZcpSmKHMJSrxaMgmYtOV9WOj4SpIzW4Oconj1GYDeRnF VnJzmIW0Zho1uc16gnCXPjTkFeMINipuc5r/JKQrv4lNVn7zn/ok6EEVek2GOvShCdVmNmcpTIRO VKHjtOhAJYpRUm7/FKIgTWg9Q6rRhpb0oxQNqUc5ClGEjnSSJ0WmSi/qy5nqk5UxfWdEV6pSi7r0 og7NaUEratOUFnWheRRqS4HKUI2qUqQPRaVSd3rUqlr1qgRNAEO1itWuBi0B/+SqVyEqVrJOdaxo TevQyqrWCLB1rW2Nq1znSte6qvWt4sOrQ7WqV7v69a/Y5Otc+7rXswK2qoTNZWIPG9hv9jUBi4Wr QiOb170+9K2CbawwKevWy2p2sJvN7AM5u1WyMvauie0AVyGLVdJaVoSuTSxbMdvZuJbVtZUd62oV G8jYWlW0joXtaWt71McitriylexkcUvc4npWsmJlbXOFW9nZSvez/9Hl7WdH69zN5la5zb0udTtL W7fuVrGkhexiabve6bqXupzFa3y9e16bAhe87/0qfPV73/E+t7z41W6A9Uve7g44vI6dbXXdS1jx 8nevty0td2GrYAqPl68Axq+C6xvc7+Y1w+81boFFHNoJI1ivDgZpimvLXM2q18ASni6ITZxf6Na3 wY19sXmJK10di1awOu7walkLXCJzWLmYxbCPeSzj7K6VxE+Ga4VTDOSt9pfAFmZyiHcM5Mdi+MS8 Fe+XzYtiLEtZvplV8lflu2Ytl7bKW15zf4uc2xXHOchtZjF9o+xi7U7ZzGnms6CH3OQdA5rA6u2x hxWtZ+hyOc9yRv90ex1t5tGyGdE8JjSko8zmCEsZy77lNJG5y14BC5fDTh7wda/84QM/2r9oNnSi D03mydY5zI3erowNnefbXlrW4R0ynb+s5Fnv9tgLFnWtQX3eRBsbybI2MrLP3OZAS7vLXa40f3u8 6ldn98XHBreRLQ1uMjNa28QmN5KFrWlg1zrdD470qKntbBZPO7rz5rWin73gMb8a0OHWdL3Jm+Qn lxnSq/7xu4v97Qrz+syehviSfVzlH4s70ubOb7bt3Gs1f9jf+LZxyAm+aSfDOdezLjCDQ95tKkc4 5RxX8733TfJxrzjdaWY3xmG+bH9D3N6ELjaXxfzwdlNc5Q8fccT/N71taie743YW9qnJLXNxO7vZ Gye21au9bzhju9wpL7rTA53xq+u85hQXerkXvmxJC13dNpc3zq/+7nXTXe1AZ7jeOW3wZx9d62Zn N7fXfnGQV9fvkpYzw7ed7UzfHc/1lrbKCx90uSt+6Fmnu7mrrnO9X5vgaye54juf9WhH3uo0R/bn Gc91X2/e8V5/fc2rvfCE21vuVf902Ee/eY9rHuyB33rtEZ93tP8e9a3HtMz7nnBjL17wZx943kcd fOAPP96h7/3sl7/16tv868EHfdkj3/vTe977ML+288f//OObfejs97b5gY9+9X+f89Uvv/cZD3jJ Ox/9zPd//FZ//48XfgKofwRogAJoftoHegQ4egWofhAYeJjXf+cnexG4fxqIgAGYgQn4gYNHf36n dgl4atCHeuEHf5Q3fyi4gK8ngS1ogNr3flJHgfDmgSA4fJ83f2yXfyqYf833f/zHeeOngw8IgkjI gSVofxqIhE74hFAYhVIIhFNYhVZ4hQCIhTZYfwiohbinhWAYhgv4hF2Yg1QohmOIhmJYhmmohjhI g26YhHE4h3SYhXVYhRughRPQABOgWiCYh8EHiFcniAlIiPVniOqFiHe4iIyIhYqYaI/4h2IYiVpI iYH4gXmIiJaIiY1odps4iJD1iYEnilBIilKoiZCYiGFoio7YiP+s+ISv2ImweIlgGIuhqIqCiIqD mIme2IuEqIiCSAEBIAATEIW86GzHuAHHmIoJsIzNiIy3+IzPSInKGIrVKI23mIyJ+IikaIjX+I2z aI3bWH3fmIvN+IuQSI3ACI3oeI3YqIzdOI2qOIq0CI6BCIi2CI30CIrSiI+giIqZiI7pmI/zyIqW 6Iyp6I/RKImryIz9WJCFuI/sSIAC6X28WJH6iI3zyI8c+YkI2YuzGIm6iIkBqYvmmJAbqZEleY6j 6I3jCI/VqJAWuY7y6JDiCJILiZIxeY7ceJHiqI03iYsBOY48qYwW0AAfQIwsmZIpmYtAGY0+uZLZ uI3miI8xiZD/O5mNVzmNW2mP7giUMHmVv/iVJSmWXDmU5QiTZ/mVP2mNY7mSZbmVEDmUOWmVAzmV 8MiT7MiWe+mSeEmU8hiXKtmOgJmVmiiVRYmWaumUUJmQzliWekmY7siMWZmYYbmYbnmRUTmYalmU S0mX6ciST+mUaBmaecmYCimX/niSkcmY77iaS9mWBSmZXJmToumWuFibeVmbgZmR79iPfnmXXamT p0mVsnmTPomMZpmYD2mZmQmOp6mZWimWVomaohmWQjmRD9mOiwmdaXmZ2BmXu2kAA0ABgFgBCjAA A2AAFdCdeVkBA9AAARAADbCe0ZkAFRAAH/ABBzAB8GgBykgB/xRQAeYJnpkIoN6ZAAqgAMrYAQaQ ngYQlhEwAQogn/SpAO3pnNG5ARFAAeTZACCqABLAnARKlwpJoFo1oBTAnGFZoh1aARagmwnwoSHq n12pliUqlQMKoJFpmf44oBMQpEIapO25mxUgAUMqpBJQoMuZhwO6m9ipXugZn/XJnmqZpESKpRMg oEWKnVMKogOgAEyqjC+qpUk6pgYKmdS5pml6mZnJom7Kpt/po2v5me4JpXF6n3DapnZJnT66k+D5 nOH5p3LqnMzZo4LZmgZ6nRtKloSKp4KpmOGZpoy6ppUap48aqOIJqJ7pmWmJm22aqXfqqYu6qYLK p5qqqBtKqP9U2Z0a6qduup2lmqqoWqsGqgACAAEVgJ8NcABJmZQQMAAMAJ57KAAHAAHDuJ8C0AAr Co8ToJ/KSp8WOp8BAAHWagChWAEguq3zyYeWOQC52gEU0Kv7eQDCqox7eAC5Op++aq4UEAG1qgDW 2q3VegB8CK/wGAADgKr0yQAWMAHH+q5pSgHBOqzyOgH4Co8KEAAHIK316q1pCrABkLAwebCiepkD cKzWurEb2wAK0AEByrAcO7INgK1/2gACYAAUe5nweaz0OZ/WWp7NOAEja60ay7EBMAEDEADDCpMt i6wWGrMCq4wGcLM1u7Efa6tKu7RM27RO+7RQG7VSO7VUW7X/Vnu1WJu1Wru1XNu1Xvu1YGurCSAB KPsBEDCjvrqfapuUDYCg1agAvgoB2NoBNKu2+7oBFACua6usAvCre8ugeQif1bq3d1uNe7ifAZAA SLm2B1ABDJCx/CmmI3C4H9AAXbqoDFuyCcAD6HmteWmvqAoBDQBZE9C3DUCpFWCuG8AAuGqj8Iiy Jbuim9u5BxCh4BkBvVq72NkBcGu7S9sB4KoABjC8xEuew7iv+ImsxVu8AwABAlC4V3oAoGugEWAA MVuMIpAA6RoAFCCuy0uez/u9whgAMFm91wtWIrC95rm5uLqe31u8lxu28ju/9Fu/9nu/+Ju/+ru/ /Nu/WOu2/0wrAc2rtsEKAfYan2mrtgrAk7jKn8WYADE6AAQMr8/qvGorAAqQpIu7n0kriPm5tue6 ATqbwKK7t0mps30LAQ9cjQS7n6drlP8ZoL36sbiJnwzbpaLbsxsAwPAoujNrr7V7jjycugMAsnBb jAB6lAewwN27m8LYn5ZZAcHarzAJoPJqACDLtM27AmCFviKAstgqxcLqh1ysWmBsmfLZvCNKrMja h6qVl9ULuugLWapVtG7cxV+cuM7asBNAAnrpoNO7AUdsAnS8i02LoADMw1nrtoq8v0mMqjycyGGJ yIdstY38tZc8tZnsv5xcq4xctZtMtZscylUMtYpMyp0Mw/+TrMqfvMP/qb3QesHLKgFk+sFqGwAW AKAAu5/Qy7oEDKBBwwAbDAFfpVoO2rccDMO5vAESrKwMOqMQYMLPC7n7GazIzKDLHKOK68z/CcDg iq2PbJSQJcVtq4yiW8WJHAGiq8u12wAQIAHZ7MoJQAGqy7v9SabBu425DKCqhawZEM4R0LwUIK/t 6bb2bADLbKDhHKN5ewBous/iiqzJOwCcOc/2mtAASrDCGqyJHKPWGr95ybsY7MrVeNBlyQDzmcvz bK3N6qYizaCsC8U8yaOPitGRjNGsrNClbJQ3ndM7HM/hrMox3M3K7MqRbNTo/NMJrcw3LcmXudRF ndQ/zcr/SbzUC83TVI3OVY3VOm3TJM3Vn9zKOd3RJP3I+zzURu3VU53UVn3WU53N8QyeON3ROJ3W SB3DiNzTX53Xbi3Xe73KgF3WQk3Wk9zIVZ3Xgp3WW63YO23XUX3YW83IfB3VSO3WmUzJSu3Yb73Y gR3U+/zZZx3Zn73DU4rMiNvEy5y6auvQO7y4SnnWBkDA5rnPw9yMiGwApp20h93MSYnFFoCeG8zL kGW9uSqv1TzTuVy0avvCoC3C9gqycB3OGQvOOUzJoG0BPizCKZsA57zWuUzEHWABR0za9gpZkp3Q uIqtUw0A80m3EIDNSn3FWXzYSh3aAJqxK2rdy+zOE53f/9283xBQoPt8xB0gnxCM1dMtxIidh/M5 2+gtt/6NoAZ+37WbxZktzw0uyBV+4XVt30K92Vht1pnt4fVt08193ScO1yW+2KHN05Dd15sN1CqO 4qNd3y5u4lbd2DR+45Dt4jdu4zs+2inO429d2Sru3Sku5Ctu2TP+3/od116t5Ja95DTO19HN5CWO 1y1+5CBe5TPe4TJ+3VmO4l0+2FN+3jIe4lQe4zVe2SPO4lT+4m+e2GGO5P9t516e55/9z6OtXrH8 Adh81ii92hMAoNH8AQGQAXxuARGgAL+cyxkgzLe86DGK2wq8z3yuoBeM0DR96A6Mt3i7pbxtrmGa njtr2v9mSwEWsOgZwMy6mucdIMaG3rZers7lDLAfC7cKIOaybs+FHtAHAM9ebsMD8Nloi60ojcuf fdB6DtrzLNBVngACrdFxLu0B/tkRMJ/DXbujPb5xzqMHO9oxHaHdLp8ZPZ9U/s95KK8SENOF3uzw Hu9VTunxTu/ybu/ynu9eju/63u/+juL8Pu+YLvD/XvADf90Bb/AEf/AKr+cJ3/AQH/ESP/EUD/AV D+mrjvCUzuqrvvGfvcEC0J7/PPIWwNvbnQHNm7MQvOiOXs2qzucbnOgDb+kcbNuf3fK97eAZEMu6 Wt/0vLbGasCofssvv+eim98Zj+kkXwEVEAEZkMOKfvD/I+/DGVC0NNyrSLzoRAzB483eepz0UT/a R7ryiu7O5pkBvRsBGC/fis7xkD7yI8/MrJ30e+7OGyDGDq70uTyfDMDnGYDrzSiMzKrUVh/ees/q FLClG0Dp8vqxcA+g2l71Sxzefm/vib+ivWv4rB71m5/xYR/2oE3yjy/1oL/no4/xos/5DK/3YN/5 G0/vbV/6bY/x9/72HA/7HY/7fp/nHt/xew72tH/6vh/6by/1wI/wnj/8pr/8nv/5vr/7zB/7Hl/5 rL/6xh/8s0/3r1/6yf/7JE/7yq/xt//4m//9sV/88376ol/8qs/5lX/74N/78B/602/9uY/+5q/0 cL/+/24PAploWVl5kqkpmueosi75trHNvvMaNZ8PVUo4y8D3ERhIlMpG2KIUf6sMo+cLxCwUg8Co 0IkSCiPSabF+IBRcRNH1NQxyg6JuHwwmqVlCchi4DJnNbEA00EyVRBhmJEwcKGREUEBg5VD8WYgd TPRBAI7UrBBuxFR8lmwkMI5sJo0mwo5AqYmubFAGWJwONIUSPkYKJTTUag0AieAqcMaGtmxEu2ww MCc5NTZgRQwcVOCAt5AkWHQwT2QNiWPf1MBMwYLtpcPb6KCAz8iwo+Dz69cLtC8fvnbhAskCKIRd O4YEH+ZTF3EhwHo3VGDzl+idGXo0HD5jiJAemHjvwv+NuodypDuUATs6iwivo0N5M9MJ7PfRljoY Kml+lGExh8GC9hY+ExTzZ0lxPDfKiqWvqcuqVdFAkFAKXJQjBhJYnQDBSAAKTtCUNcPFC1hwbnwc kNBWBFqzOLp+UNAhAYW9Cf4miBaBXDgFEL5aRWmIQWJDpQxA6mAC8oAIOCr8AWstAWQFjBOj7DZh a4ZidkWcmwt6RDfS4RogScCLgmsWEgKkZXGqQVsLjyqP0FZB9Wochg3QBqeNNrLkxTNYqyB9OvXT z69jz659O/fu3r+DDy9+PPny5s+jT69+PXvxG7B+C9cViUsLEroZ+WBJBA+y4La8kVc4YpARH39o gfP/HhmRDGXVJuhcV8ghDjLiCCQsJCAaDpgA8uCD2m2AGw4bBMOCOQcYgN0xnEwgQYsvKhBAJrtU QocddwTQgARDnIMDA7gBIMKP+2nHGYrsRICbFtpgx5kAlQQApZQBMNielVdimaWWW3LZpZdfghmm mDhgpZV8ZBhQWwb3HXBAMWRhU5dbASpAHHRGeKMcnHqypR0yemC3WGMTdmaZCBTgtoYImA2gGYqu 2AlaoTgAgNtcx0WaWBEQcNppp1R2UMopB0RZaiUQPNmJa7jVtpkIuBm6nTXW0RVAKUpmAABIhQkw gAK+Avvrr4COWayxxyKbrLLLMttsswr+YCALUKCZ/w9+AeiB4LQBkBWkCAAwgFeV3hLogwDS9ndF gmh8MIBL3rrUxmHFAUBBkKx8y4K3EjbSGTi/TftHI6lBliK8VdWrTDEWHMxNMwOjCI63ByfYjQJ0 YHxxBRE4sdsEH4P8sQINXOhtiSNSMiEPZYVD8aGKYljwgEBm0BylVVFAQRucBBaNzz7fjJLLEmsZ 5MREJzY0di7De7DSSOcrNMJBZ/d0rlObR7HVVHO3NWhKex1e2FwvLfV6Ww89dstWqn2d1WhbBXa+ Teurb5kMzfdKkBNw266haJXibd/6wRzkGF5sQHFXcZXgLVpGs4AXy1dDTbkIwaxxdNADNFCKIZZB 7v80IwAEA9bE3RgQJKOOpilWL0g3zfmhbXLegO0NcN6r0T1CXnfU+iKjSc9Ah84LYH9Fk0AEIWbF cM0f3B59Nwco+qfvdGdQQQMMwjvr3KVhAUA38WnetPYKAGBN4lKHzrXTUWP/ve+W99779Vdrff/7 N9d//++a0+9/lsMf1Nq3tgJSzn7xI6D9Dri2/hGQagCU4O8QGMEB0m1/QWvgAC+owPklMIT5qyAA J8hBok3QgQx0X9ywFkAQ+i+E8gsg0+BnwxtCMIJpoyD/5vc+DmYQhgZsnwGhlYYKtI9a5kpRrsTi A3cdCg0N6N3gAnA0ChzOB+PKFREKZDQApEs/38v/4hEmkEMicjFlGAyhhO51CDQGyQKG0JW/emeB KH2DFwD4EKLC973QJQkLG+hGjnJ0uxxx6gIZ2IA10KjDaXXDXrka4qI+QUkSQUJ1nIreIWETiQ34 a4WhKxHkthCx0IXIihkIpQHxVzre6fBoGSzhH+tWv/7JspY/tCEcH/ktSjoSmB98ZC+JOUlevhB/ 5VshAyGIS2PqUoSinGEwZZhLRxoTANecoTRzGctuVhCa0+zlMsdpS/lVE53IzCE0KalOYTKzmNsc JhyDWE8QulOex0znPPcpSqOVSYd5yxWiogW5wTUgAl+soiSNJq71QQ4Ncdnn4wiImfy88Yv7NCMR /4uBRH+GTgKoAMDnNNq+0ZWufY/oHKMYZg2GjW9ioTOaHvtogibkTFHMqFP6DuM8mTYTf5Gc6Qpn Q8QgpawUbkhTTnOmq1wQ1BA/neY5vmg4FGUOf8vJgBo1CtJu7OilJgXpPsmpTHPe8qz3NKs253lU tv4TpNoMKjnHutZx2nWucNVrWdWqTKDOlax8ratd6WrYvQ72l2eNK1v3Kli14tKxkk3gZAe71qPO rbGP1atZBUtUzvr1mnlVbGJLS9fCYtakXm1rWyc5U9V+ET6DVaJXdJVFVe7tAEaYIv4GBwHOWoCM A2CtNinhRb1WkbMAMOIR3EVU7U1xrL957TGh4P8Nbc7RtaDNwBwt0BnlmmCpFvjDcntEAT9E16qu JUIzuIA+1XK1ErZFEWhbq97iNge22tWjcmlqyQwkCr7pE4AZB0ngvM5VvpzdWeqUeUfcioaccpyi GA4M3tJatb9/da1ctcta7ZY1tfatr4BBPOL7mvjEJubwZ6nb3w9bNsVyfXGJ7ftX/eI4wywmrofv 62LYntjHQA4xaoW8Yxv7eMMXfrGSR7zjJ/M4yCzGq45prGIYW7nKo3Uyl0mc4hy3GMpJvnKQM6xl y3aZuEJWc1sHd10YD1R8/mmr5HIlAfRJVAKsBRCeDKZNvuXHwm02ghrU7IdA50G7BgiAACLBZgD/ wIajj+aCc0nauUe3dY6kg0Ti2FwMkTrXGpMcAH0wvdJcfTpzbAYrFlHUaUyvmnqwnqRRH61GgJn6 D/Y6RVlgjbpXt9UwCnj1JLXRVl7bC9OoW8M5kq3mHsM62myGtrSpLe0sXzvb2DZzma9t7W6DO9xZ /ja3yf1oaJPbw+bWsLfPrW1rr1vbZv4ylp/97mjTe9vu1je/8S1vcdfb3v7m9qz/He9/12twgmYt GpAQpPkoIGfdGIsR8ECq55HlYiNrQAUGdwTcce4AlcDoBAygZ5Li6eQffkt+3IQ7bXygZNPu+GGm DZle18uSs87udx8tUhkNFzqcaCuiMslmsQAB/wCYSe+jp2sYSb+7GBeoNqhhvZvSxAXTJoiSJG+O xGeTerhqZrCaKWDstnp92mHXJiOHjvC3wz3ucp873etu97vjPe963zvf++73vwM+8IIfPKwnQOr8 YMsBx2YG4s04gQA9CVUDWEug0ff4QHchkyzPzxUMz3lOKWAC7NKPAiTgbG0ynvP5gcCwv32bXkGd TQH4ujZJFbLbt8jSf240wx79FkAMeALOLnoDYo+MrOSK1H7GNNd3ivuQ0Z64MZX21WGNG173HtNu eC8AIMN6lZMONmJn86zUHOBgi1wB0Rd9r1y7/eeHDPyEnz/962//++M///rfP//77/+5I4MAdP/B AMZcA9jLADCauRxBAV7A4ZHBANhL6qUB9zmguRTf7uhWyw3AN/QNqWyPAbwJAQ6gIUAdBfBNgODJ AOzItdFCJdwOBPxB9HGXyHlKDRpgjvyZ0T0aD+iO0EHdw3GKIRWDIdAekEibNUAGDdZgp3DfniHD 1FGfztmaNjTSrHEX04meyB0S6GEaI9Wcmp1dYGWhIdhOlLAecXHBEi7h+P1fG7rhG8JhHMrhHNJh HeafsMhBydGBr6CerxhAyZWcsCBRjOBGorXVBAgiaznAyBRi6pye4WlDAKhgsiFg6CnKIvrhH2qi sMifNhkA5+AG7pjev91ZGeJO9B3iHKjiKpL/zsldgPBF2xZ8AwC84uktnikaojY5QO5dmwFUwBas YjD+YFu5iOJJ2y6ioppVAMjYos/BImtBoiGpXyxOABQSl4tAWzTajvp52CsGozDaYTiK4ziSYzma 4zmi4955GAUYYxwFHHE5QDMWF8ERneL9EtHJ4/6RGzs2FT+ao73wIz/GIzneo98VJKblVDwqpD+m Y0M65ENCZERK5ET2XTvCmkU6JEbKnUbWIUfCHUd6pC4OXkjaHUkCgEk+GkrGnUrmHUtGW0i6JEWm ZBvGZEvOHUvW5DGqGUq6ZE6KJJv55E3SnUoGJU2e5EzC408eZVL+pEVipDEqHlTOpFS241M2/2Vb aWRUKuJSUuVWamVSaiVJdqVSAiVSVuVFLiVZYuVWlmVZniVTSiVbemRcOuVagqVaXiVbpiVZzuVd 7uVR1uVffqVSviVf+mVb0iVcrmVf2qVdFqZIJmZaBuZg5uVePqZgOiZTNiZk6mRhjqVmymVjWiVl bmZpfmVcEqZaWuVmJuZk/mVmhmVliuZspuZiViZI1iZumiVmmmZoWqZtcqVhvqRXtiVnsuZhDiZq 7mRxRuZbjuZyxiZgSmd0hmVXxuZ1Tmd2aid1cuZ1tqYujqVzGid2Yud2jmdwlmd2pid5mid7Tudp Bqd6XqUDWKd0xmd5niV3RmVySqZhwid7fv+ne/bnf8onfKKnfNpndB6ofibofRZodx7ofD4ogEao e/JnfE4ohBroeTboa1IogdKnhAooeYanhtYnfiJoiFaoeuYnVlpniS6ohublemYod9aobVJog4Jo jMZofQLnh9onjxLogJqng1boib7ndgIofr7oftInVe6nkkZpdRaod56kd0YpYE7pllbplZ5miE6p lk4olYopiYYpiV5pmi4pV1KplTqpmo4peropm2ppdUIll9qpmMLpmc6pl0LmnLYpeHapnd5pggZq lj5pmfppoYLpoaopmLLooCqqlZYpnu7pobbpmd4opGoqn07qe76pnnJqnXZqnnIqlu5pkn7/6Jo+ aaO+KXWi6apGKqay6KjaapI+Kpym6ada6q0C6X+WKqguqqki6qh6KaoCaq46KZYm6rJe6rC+6rE+ aqviqa1m6qs2KrRWa7ZS67NSq7Nuabc2a6paK6Euq6vyKbpKa6seq7gOq7KKa7hOq7w266mCK7my a71GK7rS67xO67q667eqqrZ+q6Nia8Geq77eq74C7KK267q+K8Kqq70C7Li66r8SqsPm674iLKlW 7MUKrMR+LL1ya7oKK8hGbMkubLz2a8KGK8WCK79OrMaaK7eObMEqK8G+LLZ6LL9irM/Wa8oGbKVO rMImap3+rJzKLKkGrcQ67dNCbdRK7dQ+/227Uu3VYq3VYu3WdusFuEgeXgABcO3Yku23SsAcTEAF bK3WSq3X6qHJhW3Zsm3Z0m3dXu3cRu3N2m3d4i3d9u3eAu7dBq7MDm7h+q3dau3frq3hFq7V/q3i Mu7evu03yoHaPi0BTC7lyoEEOIA3aq4mfq4qTkCrXkDoUq7ltmrmCuPmOsDZmu43tgjq1m3pIiAM CuABCIAWlh7Vuu4qqq7oXgDdEsAnRgnuGq/ujm7hDi8jtsnt5q4WfqDsOgDmvq7oii19VkD1cm7k cm/3eu/3gm/4iu/4km/5mu/5om/6SqzxOm/uuq8ABEDwOq1IvS/7ui/u9souogr+8u/7tv+v/dpv /NLn8OLv/Tpv/+LvAFArATCaATuwADYAAZBa/VIwAt9uEG6P/HJtA6KK6qkeCUbtBcDGAQvg/77v YZBtAyagB69e8QGu4a0wC3Pek2zPk9KvBTsw/s7eADNDCQPw+yqw+grxEBNxERvxESNxEivxEg8u CsrwFM1vBsrwbr2iE0/xFcfc9i4iFntwED/pBVAcFgeAA4weF3vwk2zg1hqGGaegFkusx7GxAYyt YVjxFLuJBo9tFrLxB9uwFJtxXDwpXkxxA+AxExvyISNyIivyIjNyI5MvAYTxFDfa/MawDOevBnTw HsswJwwwZGjyJLcqA/sxCwtAAzhABWr/sgcn3tTeBgvTYB1fgRxLrAjDMimjMNZKAGx48CvL8C1j LQFUAH64cqfUMgTIbyvvsQBPbw9fcf468jNDczRL8zRTczWXb8mRzBVnhcRiLiJms+ptT4t0bskJ syV7SpuoHidcrzeiMguHswRcrw2TcyRnnMm1Lh3AcTrjRiazMARMQDw7rQHQM1yooNcu2iYbAEBT 69musTZP3j9jLaClcx4YdBnjiQJs7UGfMZVUo9si4C7HLfVa9Oc9dDwvIz6r8sW4sTWzdEu79EvD dEyPr9jSdChP77cSwPV68iArdDxfL+bScwTf9AAvcy03Wk6HbfbGSKDJ8gCLrSCrXgDU//RQO3VO IzNZaHA8X0A+o8n0VkBDs3AAaDFAx7NAe7A/33ROSzAsowhRL3BOP4IdJ69b2zTC7vTnNfX0rjUp YzRZO60Ech4k6LVa03Q7A/KTPvUVK/BUD3bromCv+DVdI6xC4/TlDjVlY3ZdSzZiU7Vm+7VP23Rk U/Zlu3VkLzBn/3Rnm3Zan/ZnTzZnb3Zm97Rmw7bUzjZVpzY3Fyxo03VmV/Zos/bVAndqr/Zo5/Zu Uy1jD7dqo7Zkm7Zvd3ZwVzZyrzZze/Zmw/Zz4zZyc/dvn/Z00/ZxT3VNpzYZnbECgLZ4kxEg57bY grEly/FPI3XDYXRwH5oMow9vj7cDUP+eV5B3WkM1ocEzTTuRDA9ATm+32BZ4YEP0eI90zCU0cYfy g+sHaVs4aYutSO2yLJN1gMNFhBN1ey/zKBMaiEs4f/sxEkg3V5MFgvf2IqKgUEv4jLM2Y5d2c994 cCu3jmd3jd/4f/94iCe4kO/3ftf1f4u4eEu3fNM2jiM5kfN4kQf5i++4c6c3jwt5Wou4j283ltO0 aAf5lYs5c5/4jtO4Xl93j0u5dPs4kCO4mSP2k2O4dYO5kbt4mDs3mz85kGe5m0/5njt5bXe5nBM3 eRd6lA/2QAc2PHP5l/f3GO85ATw4EiA5AVxABqr4l0/vVsM3oJP3faeB/Bo6jPczo+v/dX+nM+cy eYazOHpzOaeX+qh/uYc/UY17ul7DuuodOJr/dK5/sKrzenADdsvF93j/dAFsHqX/9+XxtVrXeKW0 HLDb+mVrepHT+Ki3eZtL+ZtHuaxrO5Q7+7dHerZXOrlPu4uP+7mfu59z+7i7O7hPe7xj+5sfOqGT +623u7rXe7DPO79ruY6vulNj+LY3drVTu76b+7wD+r3Du6b/e77je8KLu8Dbe7m/e8B7urXLO2GH OL3z+peLLYXDQdh6vLNjrhRDOsRLeqcPNmGjgQKQfFWzeMz9c7WXfE6HMQSYvJaj+urV/JdTOMxz vFqPtM63+5v3PEYVfMvTel6E9MeD/3xje/g2E3a4J/1u3byzxzULH7jJ2/z00vfRr/wTe71ab32t L33VF7zaq7yWg3zZr33Wtzyat/zNz33UDz3bG7rNiz3c533W73zVv/3DG/zePzzU2/3Rp73YL/66 f/zdH/7Q131jT77c433Z03vmrz2/673bv73XP763g77g6/3eJ36l533c372ss37opz7fb7zm9z3h l3zo1z3bb/7XM37mi/7n3z7po3nTm0vXC/5gY/Jueb6zT3qEkz7lobfgi3AvD/jfV32uSzXpwzWJ /8D0q/XmgTP2X31eYD9hz7yyY795c97zjz/4a3+7rH9OT7r6k76vc971lz5hF8DZy/+/s4c/CHzC RJQm4Qzf+kGXc6JxDM/1bN5lre/4b8vRZMAe8OhD/ozKZRPHDCKjUiX1eaJej9vrdloNg8VE7NcY /WKzUG6R/W6T40n5Gn6/KwSsvv9AciQBwdJwpeLHImAANLgy8NOQyAKhoVYSwBJwNHEw2RJ4IuH5 6YKTOXmgcYG09/mxCeT6qZBHgJoIqDQ7GcD6gzi5eCf5CFT8OVBw2jdwaQsdLT1NXW19jZ2tvc3d 7f0NHi4+3sT7Cvv7c4ELeYScOAyE2j7z7gchsYbccGRAmojPBqFS+WKY68NPiaNP8XAc7FNrTQED fHo1KTCQ1o+FFu9QXJFwRoEJFSf/mYrxccVJcixbunwJM6bMmTRr2rwZ7mEyJOyu2OvTEMcACAcU LKv3qpK+Qpz+3dPA7JOqHrgS0UPyE2E6gyUTRVy6s0mwjjPGej2K5cJAQ8fOGY3x7irOuXTr2r2L N6/evXcd6EzFSB07LllXBMVR4ALaLIVbFLy4D8hEp30OPDZRoLFllF2BBt51TtWPvx++XiT56nOr zkBDmeCYC+qdzCti/UhpcjHHlXx7+/4NPLjw4cS5zYLA+t7iGD3dvVq0nIAEAwYmRD/RWCmWfVQ6 lZLNPOlys5UlXJ/h/ZWCrSZImxb7ShX7jZT9KDN4rsH8chAgyEXKkAFoKdBMcQYe/4hgggouyOA3 szTQGAtXoVXAYEU0dhgBBRAIi0jYJXWZhoiVEExImJXwgD/fiVSVHwFQqJZ4Fz2QUUfLuXceYi32 wdsPy6xzzosn0PbKfSNKpliOGuKWSEgVUhLiRSUoOdsTVEqkxJVHaBnDUVdymeU0YCIx5pDRlEmm j10e6U2OVHop2ZZS5oHmlN/UeY2WeHqIpYjXLbbMUQ/SeI4ItcC5DDL0IKoheYoIeCIBiMQSqJ2J JgUVhWseVaKd6NWnUiBojVLkkEy6CEOllnoaIQSqtpfcCl9p6ueU6fVSwHKvBtqqbD+CathbIg57 YqVeRqdqrjsqYh0BuA2wgKeRSv+7KrHD7iptsmtaW2ux164KqJndwsktm9aGS+ur03oabrbeqsut ruyaaay439JL7bzkRoquvu7uG2+18+I7orbyCtwtwe1ue+66CVO7MLj2VnsewAzvG7GmjA7scLq1 evyxh/K2izGfIF/M8bj3PkgAaSqZdy2RAghbr4YYMgLnAsUIWe9RmsHc87idBp0isEpVmmKsDeXK 4ScNBD3uBY6ycACkxuJILKPLPND0JE9/myyn50AHa3waBI12yFAHeipCjVKd6b9qz601xXSrvLbK YN99d9p+h8y3we/u/Xfhcx9eM7aE98144ow3LnHeuUJueOWBD75x5HgDnrbmlmv/7DnnoXf+ueiO 1/236aofTrmGPaMdaOwtV/R1hCAZe6mhuNd68wN+5jrQJq/bDKLvucL+Nkhq54qaSXGLOHWHxkY4 gPG74x697q5P6d7HaWfPT+zDM12oUYFm7wLuk8teurHLrnDAAjEqPz7s67vOft+F53/976hvv731 +Q15/Tue7AK4P7oV0HsMvB/yfgdB9UWwgfrzH/8CiEEHLm+C7cNfBhF1QQESLoQIbF0BSahBFDpw hRxsYNgWyMLjUTCEnxNhCmf4QQtGcH/iUyD/DIhAGeZvdreTTo2EcahAPaAYM7NhpW7mvwFURHhA nBwBshM3Ia7wASW6YdG+I0DY/1TGagV4AJCKdD0bEhGNHuRarEqjPiG67gHve4QAtVipBbStGTJs lRY9iMcUOnFY7jEA1axDQ/yx749VNOAKe7hI/0kSjyWkZBwZCclJ5lCQd/SeI3f4QSuq0ZKKnKT4 0nhKQDbyk69jZSgVecpIOlGUjqwlJGupSlcGMoarXOQlJbjLW6Zxh4/EpS0bmctXGhOWnYwhM5Ep TGgOcpXLu6P9rGlBa2rzmcfsZi0fdDyXfUA0BmSi+bqJoQAMAELrrAoVj4lFbtpyaMe81VOSlKvo QcKRYrSPN2u5Rwk94JtvPOc/C9BPPh70eCp6RfiUFaSFSvSgdYQALhqwgIlqdP+jHO2oRz8K0pCK dKQkLalJT4rSlKp0pSxtqUtfClMggnNytvvA0463xGB584qFimg3eUqQiXKxEN3EQENjg9OA7tOA GLCnVTSqAWDdzpFuVM9ENXBEPxj0oFH1KURf8aKXLqBr5xBQTM+K1rSqda1sbatb3wrXuMp1rgYc 1PESqtWB5sqc/6wpWPtqNo3S05ZHVU6uLqAAUAmgeno1YEAf0diDksqhzMSRRLtapMj+E7OfoOL8 nCbPk+K1DwHQLF1Pi9rUqna1rG2ta1/72pmWUY9vhB8ic6q7n/q1szvNjnkkOtSp2vKLwmhAO4UR ALPW0qhS/YAyrtrcmxqwqrT/mOhj4ajRrJL2eFjND0x9lz1ZwXa85C2vec+L3vSq96x2xWl4YaFX c5q2nKE5gH0F0JmwHhO3zhMsU7rZvJ42aQEPmO9Ealu9iU4WtAS1qkSvC62JLkC7muBudDPqSAUE YMMc7rCHO9wACRg4V5x1HobXi+IUq3jFLG6xi1tKXenmagEcoDAfdabT/QIViRyQgAaoM5QKe1Mz Z5MoBko03wcwV8C4Kmphnwrd/GgWA5Y9qFFrK+ODEsqh3LUxLGrJXyYbpsjdxPFfX4zmNKt5zWxu c1oHWuBcxRmn02Ua7eBcxlxdd5wGwIA5MVBnvYbZD4socIExQN0X4VnQe8VU/56p+mg5ByPBczag U4EyNgOcWLPXbUCSbbngSVBazhsqqGkrrdcSN6mxkdXsAyYs5RnXERYZZfRuCU3mbpLVD57uZqXr TOrhsprOw400qfHsTUYHW6iQHvaiy+hqYxO72Pv1tbCbbW06JxnZkAbzdOHM6jm3Ws6/vjaxPx3s ES973XkuN07DTW1oL9Td2m61oLkdaC17m93NBveyow1serNb4JGOM76l7W1XD3vf7072v7vNaHVX W9nZpqqhyU3ucF8c3Ha9+AIQ8N7S8tXg9yaSMAzgb98FD9wpNzlANGBocStbyYpq98YR8GSqKUCK XIZ2zAuAgEsjBOMxH7eq/f/pcyVX2eaLHujRSdv0XxfdywkuwAJmDYGil3EoB6gtoQMgYqaD+8po xHi7z+3vgv+c5O82eMaRnXZ5S/3iTP+2z82O7ZJHXO4aX3vaI150ksMd8IEnPLztTvek373lhW87 qjPe8KQ/e/CN3/ix783ythP92Iune9Sf/Whx2/3tcpe85UN/esEH/vL1fnjKC4/qcbP+7ZhnvL0V z3m/Y/7sYsc77TOvebfbm/GSR7zvVe943nse9pNnvqEfhGiWP6DGPV1nsKIP+5shQPo7c/6gK3M2 78ccGQrA/tpzrhIOmPnkBC58d8HKAdPDPtSEVsDGC+we80s/5qOFRfhXH3j/70cL2DdrqiB9GPBj BjAAs1YbBqAB7ad1BqcBbwQtACh+lReBF6iBzCd/uud9ipeBIbiBI+h8HUiCG2iCHHiCJJiCK/iB LuiCpld8FkiDMGiDa9eCNmhzOXiCPHiD+weDPqh699eDQ+iBLkhld7Z6ZBcaAzEz3tc7P8cBkwKF 8TEBG3h1LGB/sLdkqaABOPdGngZ7WZgUECh+Twc/KFd0COAeI1iAMCd+VoeGIqCGAxUhhVZ4GBB9 vWKGzjeBmfWDgSiIg0iIhWiIh4iIiaiIi8iIjeiIjwiJkSiJIzgLAcABXPheilB+zqd9gTcptZZ9 z2EA23eBsCYr+hdz6NcC/zBHhoCBigUWIVXzioX3WBBAikWXfxuYPQIAhxeoiquIfbumVR7gfX/Y WX3ohxR4iZPIjM3ojM8IjdEojdNIjdVojdcYc0lYG8sYeAjIgJpYhQESeDjXAOrkfCD3HFt4gZiF h3moigbIAcJYCLAXj2Ojjt6njU5TePFoahrIhuWjgUzYCxAIhlLmfAswh6WlgQhJgdjokA8JkREp kRNJkRVpkTCIfaiIijznfya4Z9fHiaJIjEWHAQigh3rIfNkzACiJj7OgCuYXfYimipVAYHMoi4jG kklzDisZkySpZPjnFtwYc7mYhwEYXThpaBpJXaJWdKZ4jCQZkwhpYwr5k/9VWXgBZhVC2Y2HZpXZ mJT4yIVgmY2z2I36B5NFiZRcuZVfyZVkyXw96ZbiF5dj6ZUYGZZFGZDO15MOOZd6WZUZyZYXmJaC +IpkuZeCWZh+qZaHppSz2JeOuZaLeYJzaZh26ZOS6ZWD2ZiMiZPBEABmmJMlmYlPuJgxGYU/iZOp iXMDoAAwh5P/6FCYyZiH5plCeZJK1oWxgZMR0gCAqYccMGufeZuHqYceED1VM5sFxo/q8ZfdqEcP 2Iq90JaciZoeII90iJSIdodXKJs0NpVmeZbTZ4yiBpPlGZ4neZtfCZioqZbrmZY5WZrtKZnD+ZbT 2ZXy6ZtWiZJm6ZN9yZ7/SZmdXZme7FmebAmf97mfA5qHqVmX1ImeydmgdNmf0zmcLEmZEqqeqamZ AIqb9xmYuKmgFhqZk0mXhbmX62mgiQmXE6qeUJmRCuqhHAqVM5qZI1qaCSqfMqqY7ymXKJqeAQqi OIqeGhqTGuqZcEikJwmcPTUzQ0qgN+MB8DmcWTgzHHCbpBEAHgCBFbqfF0VgBJakM/mAevhYi2CS IFpg2fOSGgqgJ9kYAWCSXJp/DDqkTUUUDVCPZrMAScqZfgZ/PwphdfqXApgIpVWngopo45mVW0qn XIqo+9mnh8qnghqkCXqWklqp2ZmkD8qpf8mmmEqkQZqpn6qpnsqplgqq/2jaoU7KpbMpqT/6nhZ6 qKJqoP/Jo6/Kph3qoA86qpt6qmj6qKi6qq/anhWqq6QamsBKrKEpq46Kq7w6q7japvSJrJsqquBp rNLaq6caq8+6qmMZqhvarI9qqtT6akO6AOmKAXt6kuy6rkNam+4qrwTGAXvWpHq4p+6qhzeDru+q hzhHCiuprhwwhyPwrOvKWdCCr3UKsFKhAfjqAcG5sO06h6VxsDT2PveKnnu6nLSgr3VqnfCDABWr AB/7sXpYR+XXrg+AABEbJP46sYhGfZ11sa/GkEWysYfKrvIKsxt7su36rj97sD07tEKLriebrj9r skN7tEwbtP6qr0m7sP/q6rSvGrU5m7RGu7NVy7VLq7M8+6xaC7S4urV1arSSyrNU269k67VYu7Y5 C7c9e7VoO7Y6y7VWC7NzW7d3S7dxO7Fn+7VzW7Z426/5GrMxC7Zpu65SC7XqOrjBQJP5mrU7uwDh NTMmKbmLu68iqbY5iwj3yq4zmwxRKrR7Ggw3ObULK6aOe52GEqeUGyEBgLhZq4doCAFWKqnusX24 ujOmGySYq7lAi5BGowG4O7WtC7qMu6caUEeGOraUi69YaR9aarhQ67NBW7aCC73b27jz2rn4qrxU m71SO6/Ca7jiS7vfq7bkm7ph+7R7+77BW7hIu7ed67iJC75Pa7/Ve7//eWuy7Du7lLu165u3aLu+ 1Xu4qYvA3zu1/Fu6f6u54zu4A7y44iu35Ou1Apy/mau40Cu8a8u4z9uuC6y/Cay38tvB77u96Au3 7MvA12u9bfvB5eu94IvANjy5FTy5IYwMazrAk7uk6bjDQ8qvGLywCIAKvBjBHNAqVjrE7yqAstu9 7+oB7wid6YoAXna750umUiWLOWzD8jgzHKyu1llQQ+yuDYVRBCtVi+DBaqsTi9XA68oBLgtW6Uu1 hOoiOozG6UqwFFjBgRy8O0zIJWzEjTvCGEzI5yu5fazIjNzIeHzAOczF4VvI6Yu9DrzIaDzCOuzJ fBzJZIzJoUzK/VvI/yJ8ymDMwpd8yjg8xZIMy/dLyt0LyY4Lyka8yHN8yxGMvqbswgKsyLTMyrlM xgUsy7J8y8rryf27zADcyBEcyM9sy4ecyZm7y8Bcy5Qczc9czb6MvYNMtT18xdictL94uc28p1C6 ybSlEuOcrq3rXNVcwXHRwFy8ulkbXgqgfo2Mjg5lw9VcGFmKABZ8ktmjAJgryZO2uOBDurkc0FH6 zYtbpgetwgjZvIm8yQLZJPtMu998zJQM0sP80cT8yLEsypm8zTic0aUczMzc0eu8yisN06kM0xvc 0fIcyt0807zsyyU90zUtyrjczR490ni8ywos0iyd00A9zapcwz690v8oHdJgzMfRrNM7zckY/dM8 3cfbTNLJjMy9XNLoHNLX3NW4wIuOrK4mGT1jDMt+GiAZjQG4YIlAXLFVs8gdu4owXcWx4sPp6gFe pgo7XMc2htd5/XSH3ct6aNBHzVklC9h15Ma5/HSTXch1jD7uzK56TFoqvdj56DVKTdKzHMtgrda0 nMygrNJg/c+cLM2jLdMm/dNJndRVndqmvdWmvdpjPduw3duz7dW/Lda+TdayzdvCbdS43cqTLNq+ DdWrnNquPcysjcs97bOjbNtVPdVArdxPfMxoTdE1jQFBDA8KQL3FPGvmPdCEzAt4SsjhVRT/mrRT 2BUDgNCLDJsnR73/iwvPvUnIv5ilm5wVM+MB673IvDnQt9zDo7i4CanZSTs15s3RaMzEQfKw0czZ mmDT+N26AQ7cyD3S3f3hIN7cxE3bJI7cIo7i273VK97ix6zivx3jLu7cam3cNJ7iOL7ORK3jPf7i NB7jZp3jJZ61Bi61BVkIP22SDVve62rkHzeyF0bIIOcU0DK5LVux49QArfljGnYP553XxrmTRY4A SJxpO9yypNEABp7gbJgcAzDhaG7mmPJxk+sBDVASNOnk8ShVGLXDfe01HPDkhEywwenObAxWFTzo 692ysfjgSTvQg+7jUz7pkl7nV37pws3o62zp+D3pkI7pSs7poY7F/7Pd6UVe6myO1ZW+4q196qz+ 6aMe65du5Iz+6jtO6qR867Nu6my+6KA+65Hu6aietMxLaAPgAepn68Le5o5C4JFu5BpgOwKgTgpg 7TvXAMgBFAcN5aWep4UiAAeg7X9gAOdd5qVezs1VCYJ+6b+4inH+cWr+hZCeWKKW7Ohe5PRdKP5x 7dae7S6y5PTe58UL7fXeJP967rWe6tJ+DhCg3kmLpU++6Zdu8A4178Ke6pmO73J+5WUO7bkO7JSO 7xIP6ecu690+6iY/8rWu6iGv8lgM7Qk/5SRf8sMu6Rgv8jLf8t3u8aie8Dgf8jAP0x7/8Whe5y9v 9Cjf8UUv8sS+yf8qv+k93/QuP/NDr/EZr/S2fvTo/vJIn+oTv/I+v/Vj7/RkXvNhT/Ix7/VOH/Ud D+oTr/Bpv/Fnz+xWL+dED+VRrwEK8O8mYVzmnfcmv+Rzvu0fT7Dr5GXwIALJgddQjwCYLWblrew9 T/TY7nVaPgCj+HFm3PCaRvkeYJ1Sxe8GoGGssVjsnullrgEDsICXrwgi4DQf7/EVnwusSfp4Dg8r SfTLnvd1jtlvRO22rwBaLOgxD+UEu3MB4PoQ8Pcc/fNab/w/n/p4j/coT/11z+yCn/F13/vUn/pm D/3ZT+bLvvuUX/1cD/Vvr/27z/Plf/Tpr/bRD/9AD/PcT+vSb/3/2t/9YJ//IIAsCDmSpTia57q0 7CnGMy2rqFvee/rCas4mNBGHN50LuELJcMlnL6asHY/Ma7LWlOay22bRSQsGhcYuTopl8pBoYuvl 1dJjig8+r9cLDJ46hsHBnoDCX0zDnuIiox6ERh3CgEBjI4RhZEAlY8MhgsfAYOPBgCcJB4eBZqMA 5SKEX93dJq0iZo1GgOtiK+OlaeRM6mplb+WjbO3iAWSw8zN0tPQ0dbX1NXa29jZ3t/c3eLj4OHk5 uMdsrUEwuu2MR6KyfEAkBzqEvEBDc50H8fw7Bbos8Xs3AJ88UhqAMWknr1afSAcfKkSAoZoHDxoE 7nooIMAAAxzo/zh8iIeZuZQqV7Js6fIlzJgyZ9KsmU1VgJw6d+5cyK5Bq1YHbp0QyPMo0qQ6FTjj sFFXRz4HGhhiWGOAUqUDLgpTgPVA0DwQ/iw5gQEdVFYgF1qdgTMr3KOd2p54KoqRAAgD2GrL6BWC Mbx5G+zNmLHO27g899G16fgx5MiSJ1OubPkyjYwaNnPu7LkxAlQaB5AmXdCe59SqV39+pllBgwAQ IBygDQEkUXasd1s1rMGAV9INCI+kYk+jV9m2awegqqE4O427p6+GTtIv1tm1mTv3YD2bb68NtC/P OUCBH+/fa2imvhoz/Pjy59Ovb//+yvXYjhv+A+y4fuyA54l/JP8YNs1hkRwyUoD9+ZdgdP2hYuAn 3mmh34Tb0GUdf/6hMtKDAV4jWn+ffEJiidGIyF5oLbqozYrlxAhjMDPiN42NND6TY03F8XhKNj8G KZ+Q9TR1Iw1FirgkiCYe6SM00EnJI4M1ckjOf9J892OVWwozI4MZxlDlixfuVwOGEwa4YpFJusjk mHWsx+U3SwqzY2hkmnnnlXi6GSeQ1WQ4Jx1kehmlNRzGqGeXf/7ZZ6FysnkCoVqiSSmgp9io56Ob XkqpmGWCeueTn375JpSBGrknkJw6OqadmMoKao5zYpjnm5iGKaesH65aqKGVNoprpW4Gm2urmia7 5ouMjkqolJn/Tjlrqrvm2eW0YnLKpo9qtqimq4MqCiysmQZqrbGiQrrlts9G+22z0aILL67Nqqrt ruPOSiq19dI77Ieu6govlJB+266qXwp7apzamntvmQEfvO+9k0a8aqoJd1tstw2D+y69o/ob8aFm KopwmKGqm+ityaLa67LXiuryyqbya6q1BQOsssgaIzsyttRiu7HOKZ/7bL8iZ0t0wiHfTOzL3naM tL2DVq3z0RITm3K7Qf9ctK/e/svq0f6Kq7DY4Ur9MdTKsj20xPhuXXarObudcd1Ya+pw23ZbvTeg TPt695RnCz144H63Xe/Qc18rr9hAN+50vIBPPbXHE4sLMprs/xbet7uIOz5xwyM3PbDX4Mq8rOgB O7w55QS73jTPpsN9N62MFtxrtQPT/Xi5274bqtaYb2287267nHHcep8M/PJrux429LYbzbXM2E9f ON+Ihx03wY9Pn/3eG69evKEHYy872y+TLDjc4B9/7PZWD57z7h9v3/PVucOvvuW8pz6jkU96yKtf 2lQnPPBxjX7KCh33/vW95glNXfLDl/4miDXzeS9fUFugBOHnvHz9rXy6al0DxYcqAnJQbgz8oPbi Nz/AxWt8UhOf3rLHQBZWa3YBvCHqGHfDcdkwdewLWvPSBzwMss5sOwNb9crXwvvB8IQNzCAOi4es HWZRf12cHf/RwLg/KSKwURq8nw2/WEbqKRB9b9scGxGIw7yp0YNXXOMS11fHDq5xf2ckIhuzmMfv dXGQfExiHMc3Q0L6sIa6u54Y00jB+s0NkT68YPzM2Mcj5q56b8RgBu9YyB2SMH/cGxYZkzjAMCYw kqyLoQnJqEMSrlCBjnShCp3ox1qWMpRypGUvVYnHWO4RjGYToioBaD8q+nGZhFRhKHlpSP/1kZXV xOM1RfnJMkqxmHC0XypnGckirrKIGpRmx6JZzjlSEovjBCY1s1lH6L0wm39EozB/mccAzu+K3nzn OAeZS3siUpwx9OXx/plIN7qTnO28ZiXvCdGH+vKXFMTdQOX/OUDCTRSbcDzfJR3KTjFCs5t33KRF zenKM4pzlKOsKEHlqFADNlOlJ6VoTFOa051Ws58S3Sk9e2pTnnbUmiO1JFFrmlSkEnSmJF0qTpnK UKVCdahSjSpPNSdJoeoUoFwd6hFh6lWHVvWnQO3qUmepUKda8qg5/SJbsapNexr0qWU1p1tvete9 8rWvfv0rYOVoIb/GlZuBPSxiiVrYxDIWpY19LGRjKjP1fNWjkb0sZs2aWapaNrLe+aw9EKgeygaM tGs0LWozEtr6mVY02xstQVWL2jLCdrWuzWlrXZdb3e52taDNZm9pu1PVvha4rC0tcl3bW9KCdrm3 ZW41Kftb/xLpNrnTHS1xZxtb45YVutMLbnK/G97gtra8vhVucfsoXe7e9rgAAm5uwRveD8lXvO2l 733ze9r0Vre/+uWpd+173qXKFr20rS9+Baxdoq6Xwcb9LHHtKVsHYfe9CX4vdmGb2gJP98K2PW+H LczbD4eWvCCuLYZtC+EUx9YwF9ZwhC2sXRRX17mlrTB9mVtgFf8WxtlNcIyby+P1mldCtf3xgFlc 4g8HOcLg5bCHZ4zf+Aa5vzEmcYifS+LiSjfAKLrvgqkrIQwjOcn8Ea2Lm/tjGr+4x19+M29d7GEF +5bIY76xiAWc4w5rWMXzXbCTc/xaKn85zO3NspCr/N1AC//6zEve8p+nTN35AgjFVd5tkwet3Ei3 WdETHvGRvatjB1XayWoWc6LFe2QQn7nBpDbyp4Xc6jRfmcI7vi6ET31dGed6z5tWrpozTWHkuhrJ xi51gFfNZEV3SNZ8/jWUex3nEnta1bSm9qijjWcy11jQY6bxpx2NonDLudnADvWaVyznVee6xyum tpKBXWksZ/jb8T63aDctbF8fe96otjS8b/1odcP5zlrm8ZR3fPA0W7fRDF83nsGdcILr+85dNjKy ye3sSTeayRlvN7QlLeY3E7ngseZ3oeU9ZIK7++LqnrCPTe3fYGO80Bqnta43jm1S/9vlS+Y50GEd dJhzW9b/z9XxuGFd53GL29w4HzaLbf1qoa8b6JK+drs5nHWtK3zWH8c2v4dNdDfPO9FDB/u5b/7v Zme35V6HeXwHXmepQ93UWU961aEO9ptLG+51Zzq8l25xR0/93eIWOts7JGPFs73cYw881W1N7y7j Pe90Nzevg575gPvZ71Ofe6ovD/eJc97xWLe71G3+9J1H3u+J33mKT95knB+68Pi2N89B/3S6j573 jW8765Uu/MK3vfVab3zlxW544/ue+b1WvrQJ73mmD932zec99LFP/Oxrv/ve37rke/988Yf/+5If 8PWdDv7Ue/v3qb8713ePfcK73/Pcv/yenX97qtcf9tt///WsmZ/ozd+tjR0BshwC3t3RBeD9CeD1 /R/49V/1ld74yZ/9Jd/68d//1V/5baAD0twHhqAIjiAJlqAJniAKpqAKriALtqALviAMxqAMziAN 1qAN3iAO5qAO7iAP9qAP/iAQBqEQDiERFqERHiESJqESLiETNqETPiEURqEUTiEVVqEVXiEWZqEW biEXdqEXfiEYhqEYjiEZlqEZniEapqEariEbtqEbviEcxqEcziEd1qEd3iEe5qEe7iEf9qEf/iEg BqIgDiIhFqIhHiIiJqIiLiIjNqIjPiIkRqIkTiIlVqIlXiImZqImbiIndqInfiIohqIojiIplqIp nmIThgEAADs= ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/clinicalpractice/images/cme.gif R0lGODlhKwArAIAAAHt7e////yH5BAAAAAAALAAAAAArACsAAAJvhI+py+0Po5y02otj2AHx9AHc 2D3kdoQpKp6lw7bluLKxdIv1S7dV7unwfDKS6aVAKYUz17Gx9NmQGiqv2TQAIbHQNEukOLVYMvmE U4WvZ2PmDY/L5/S6/Y7P6/f8vv8PGCg4SFhoeIiYqLjIuFgAADs= ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/images/icon_doi.gif R0lGODlhDQANAKIHAJOTjlpaWAMDA///7L29tyQkIuLi1P///yH5BAEAAAcALAAAAAANAA0AAANC eEpRUsCoCaAZBghAwx0gBh1E8QkoSAhDAIDskLbVF85AEN87Y/KhQc4VLAYIhp+sF1DUiisCReAi DKWTg7BxzCYAADs= ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/common/images/table_thumb.gif R0lGODlhlgBuAJEAAP///8zMzJmZmQAAACH5BAAAAAAALAAAAACWAG4AAAL/lI+py+0Po5y02ouz 3rz7D4biSJbmiabqyrZsAMfyTNf2jef6zvd+vfgJh8Si8RgLIpfMplOnfEqn1GG0is1qYdet97vs gsfknriMTs/O6naZ7Y574fJ6dQHI6/f8vv8PGCg4SFhoeOiHh7jI2Oj4CJmnGElZaXkpOIm5ydm5 qPnjKTraCOpDipqaqbAXqvoKC2DaE1uLOstjq+uJu7P7i6kJPBwrTHx8y6pnxyyz2dss96ycF908 ndBqbYeNgPydCr0N/ihuTe5oHo1eSg2wTcPOaCxf355tn5/urt9fSO8vYCJ3Lgoa9MZHkwCBARcm JMjQn8M9CiP2m6inosV8/xglQdxor6OsjyDlidRYkt1JggdbtuiDMiW5lfgkyVQJk+TNbzQRenQJ FEXOmrIsiQR0FKmhpAkJMaU4qOcBqEWaLnNm9d9Sp1yjen1IdGFVqFdjwDz0NGugtDa/VsNaFKzP omMzajOr1q1epXv/YJxhV+5Uu3XbvsVLVqviTF0Zl4URmKJOSGwjN+6b6DLfw5ANZ4RYOK5mwHnX XibtebPqn3PFEim9GrVlx7TfwRVt+nGA2SPD2h4C2y8f2alz15Zd+S9cqQaovk68lzju2qqRn14+ tLXRrdw1C8d8VjfviqErp5bekbhyxLiti+cdXrLv8t05786r/m5nz+7tQ///Lp929C3mH363tXfb evshyB5bzGHkGnD/GVfgf/m9x1+C+t1XXHyf+VaJedNRR+FqAJaYmWDNEfYcfCeCl2KFDC6oIIcz cvigcxK6GKN31WmI4Y3QoZYjizt2+CKJPza44ZBAVlikTQP6aOKSNDZpWX+/7RfliOnUB6OHVYqZ JJnktZghe0iWyWZwammZ5JlHCulmj0qS2SOcdvYmIJp0TojimHVm+aSJcgrx5oFeCopno4kySWJM lIF5556WOgpoaQoFxWkJ2Q225k67dCmiqKqQaipPn64oJTzXoLUqhFu6Kg2sKspKKzOIoJorN7YG COqiqdqC6rDEFGssMKRKdspsCLEmyxE/0M4k7bQ8VWvtMQBlO8y23P6iTq9pUOaOuLqWU665dZBL lLrrokvUt9piK++o9NZL7L34FqPvvq946++/zQ4MVAEAOw== ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.nature.com/__chars/gamma/black/med/base/glyph.gif R0lGODlhCgAMAIAAAP///wAAACH5BAUUAAAALAAAAAAKAAwAAAIThI+pFtcO3kNStZkCpov1+IVJ AQA7 ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/includes/header/03/style/header.css BODY { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = BACKGROUND: url(/common/includes/header/03/images/bg_body.gif) #fff = repeat-y 50% 0px; PADDING-BOTTOM: 0px! important; MARGIN: 0px; = PADDING-TOP: 0px! important } #constrain { MARGIN-TOP: 0px! important; BACKGROUND: = url(/common/includes/header/03/images/bg_constrain.gif) #fff repeat-y = 50% 0px; PADDING-BOTTOM: 1px! important } #hdr { BORDER-BOTTOM: #fff 15px solid } #hdr .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 4px; PADDING-TOP: 0px } #hdr .publications-search { FLOAT: left; WIDTH: 100% } #hdr .publications { FLOAT: left; WIDTH: 100% } #hdr .publications UL { PADDING-RIGHT: 0px; MIN-WIDTH: 24em; PADDING-LEFT: 0px; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none } #hdr .publications A { FONT-WEIGHT: bold; FONT-SIZE: 70% } #hdr .publications A:link { COLOR: #313131 } #hdr .publications A:visited { COLOR: #313131 } #hdr .publications A:hover { COLOR: #ce0808 } #hdr .publications LI { PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/bg_publications_links.gif) = no-repeat 0px 1.5ex; FLOAT: left; PADDING-BOTTOM: 2px; MARGIN-RIGHT: = 1.5em; PADDING-TOP: 3px } #hdr .publications LI.li1 { PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/bg_publications_links.gif) = no-repeat 0px 1.5ex; FLOAT: right; MARGIN-LEFT: 1.5em; MARGIN-RIGHT: = 0px; PADDING-TOP: 5px } #hdr .publications LI.li2 { PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/bg_publications_links.gif) = no-repeat 0px 1.5ex; FLOAT: right; MARGIN-LEFT: 1.5em; MARGIN-RIGHT: = 0px; PADDING-TOP: 5px } #hdr .jumplink { DISPLAY: none } #hdr LI.nature-link { PADDING-LEFT: 25px; BACKGROUND: = url(/common/includes/header/03/images/bg_nature_home.gif) no-repeat 0px = 5px } #hdr .nature-link A { PADDING-LEFT: 0px; FONT-SIZE: 100%; BACKGROUND: = url(/common/includes/header/03/images/nature.com.underline.gif) = no-repeat 0px 90%; FONT-FAMILY: Garamond,serif; TEXT-DECORATION: none } #hdr .nature-link A:link { COLOR: #ce0808 } #hdr .nature-link A:visited { COLOR: #ce0808 } #hdr .search { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 70%; Z-INDEX: 1; = RIGHT: 0px; BACKGROUND: = url(/common/includes/header/03/images/bg_search.png) no-repeat left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; BOTTOM: 0px; PADDING-TOP: = 6px; POSITION: absolute; TEXT-ALIGN: right } #hdr .search A { COLOR: #fff } #hdr .search LABEL { FONT-WEIGHT: bold } #hdr .search SELECT { FONT-SIZE: 85.4% } #hdr .search INPUT { FONT-SIZE: 85.4% } #hdr .button { BACKGROUND: #f9f9f9; COLOR: #000 } #hdr .leaderboard-links { CLEAR: both; PADDING-RIGHT: 208px } #hdr .leaderboard { MIN-HEIGHT: 93px; BACKGROUND: = url(/common/includes/header/images/backgrounds/01/leaderboard.gif) = no-repeat left top; FLOAT: left; OVERFLOW: hidden; WIDTH: 100% } #hdr .leaderboard .padder { MARGIN-LEFT: 15px; OVERFLOW: hidden; WIDTH: 728px; MARGIN-RIGHT: 15px } #hdr .user-services { FLOAT: right; WIDTH: 208px; MARGIN-RIGHT: -208px } #hdr .user-services .list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 3px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #hdr .user-services LI { BORDER-RIGHT: #a8a8a8 1px solid; BORDER-TOP: #e5e5e5 1px solid; = BACKGROUND: url(/common/includes/header/03/images/bg_user_services.gif) = #efecef repeat-x left top; MARGIN-BOTTOM: 2px; BORDER-LEFT: #cecece 1px = solid; BORDER-BOTTOM: #a1a1a1 1px solid } #hdr .user-services .us-link A:link { PADDING-RIGHT: 2px; DISPLAY: block; PADDING-LEFT: 37px; FONT-WEIGHT: = bold; FONT-SIZE: 70%; PADDING-BOTTOM: 4px; PADDING-TOP: 3px; = BACKGROUND-REPEAT: no-repeat } #hdr .user-services .us-link A:visited { PADDING-RIGHT: 2px; DISPLAY: block; PADDING-LEFT: 37px; FONT-WEIGHT: = bold; FONT-SIZE: 70%; PADDING-BOTTOM: 4px; PADDING-TOP: 3px; = BACKGROUND-REPEAT: no-repeat } #hdr .user-services .li1 A { BACKGROUND-POSITION: 10px 0.3ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_account_red_med.gif) } #hdr .user-services .li2 A { BACKGROUND-POSITION: 10px 0.9ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_ealert_red_med.gif) } #hdr .user-services .li3 A { BACKGROUND-POSITION: 10px 0.3ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_register_red_med.gif) } #hdr .user-services .li4 A { BACKGROUND-POSITION: 10px 0.5ex; BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_subscribe_red_med.gif) } #hdr .user-services IMG.usi { BORDER-TOP-WIDTH: 0px; PADDING-LEFT: 5px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr .user-services .ad203x90 { BORDER-TOP-WIDTH: 0px; PADDING-LEFT: 5px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr #header-nav { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; LEFT: 10px; PADDING-BOTTOM: 0px; = MARGIN: 0px; BOTTOM: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = POSITION: absolute } #hdr #header-nav LI { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/includes/header/03/images/tab_l.gif) no-repeat left top; = FLOAT: left; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #hdr #header-nav LI.hilite { BACKGROUND-IMAGE: = url(/common/includes/header/03/images/tab_l_hilite.gif) } #hdr #header-nav A { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; BACKGROUND: url(/common/includes/header/03/images/tab_r.gif) = no-repeat right top; FLOAT: left; PADDING-BOTTOM: 6px; PADDING-TOP: 6px; = TEXT-DECORATION: none } #hdr #header-nav .hilite A { BACKGROUND-IMAGE: = url(/common/includes/header/03/images/tab_r_hilite.gif) } #hdr #header-nav A:link { COLOR: #ce0808 } #hdr #header-nav A:visited { COLOR: #ce0808 } #hdr #header-nav .hilite A:link { COLOR: #fff } #hdr #header-nav .hilite A:visited { COLOR: #fff } #hdr .journal-header IMG { BORDER-TOP-WIDTH: 0px; DISPLAY: none! important; BORDER-LEFT-WIDTH: = 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr .journal-header-image { BORDER-TOP-WIDTH: 0px; DISPLAY: none! important; BORDER-LEFT-WIDTH: = 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #hdr .journal-header { LEFT: 0px; WIDTH: 60%; POSITION: absolute; TOP: 15px; HEIGHT: 74px! = important } #hdr .login-nav { CLEAR: both; PADDING-RIGHT: 10px; BACKGROUND-POSITION: left top; = PADDING-LEFT: 10px; MIN-HEIGHT: 124px; PADDING-BOTTOM: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: #7e7e7e 1px solid; BACKGROUND-REPEAT: no-repeat; = POSITION: relative; BACKGROUND-COLOR: #666 } #hdr .logon { RIGHT: 10px; POSITION: absolute; TOP: 0px; TEXT-ALIGN: right } #hdr .links-above.logon { TOP: 2.5ex } #hdr .logon A { PADDING-RIGHT: 0px; BACKGROUND-POSITION: left 0.3ex; PADDING-LEFT: = 18px; FONT-WEIGHT: bold; PADDING-BOTTOM: 1px; COLOR: #fff; LINE-HEIGHT: = 1.3; PADDING-TOP: 1px; BACKGROUND-REPEAT: no-repeat } #hdr .logon A.login { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_logout.gif) } #hdr .logon A.login:hover { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_login.gif) } #hdr .logon A.login:active { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_login.gif) } #hdr .logon A.logoff { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_login.gif) } #hdr .logon A.logoff:hover { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_logout.gif) } #hdr .logon A.logoff:active { BACKGROUND-IMAGE: url(/common/includes/header/03/images/bg_logout.gif) } #hdr .logon P { FONT-SIZE: 80%; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 8px } #hdr .logon .user { FONT-WEIGHT: bold } #hdr .logon .inst { FONT-WEIGHT: bold } #hdr .login-nav .list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 70%; RIGHT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; POSITION: absolute } #hdr .login-nav .list LI { FLOAT: right } #hdr .login-nav .list A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; FONT-WEIGHT: = bold; BACKGROUND: = url(/common/includes/header/03/images/bg_register_list.png) no-repeat = left bottom; PADDING-BOTTOM: 6px; COLOR: #fff; PADDING-TOP: 4px } #hdr .login-nav .list A:hover { BACKGROUND-IMAGE: = url(/common/includes/header/03/images/bg_register_list_hover.png) } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/includes/footer/03/style/footer.css #ftr { BORDER-TOP-WIDTH: 0px; CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 20px 0px; PADDING-TOP: = 0px } #ftr #footer-journal { PADDING-RIGHT: 1%; BORDER-TOP: #000 1px solid; PADDING-LEFT: 1%; = BACKGROUND: #eee; PADDING-BOTTOM: 2px; PADDING-TOP: 2px } #ftr #footer-journal:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } #ftr #footer-journal P { PADDING-RIGHT: 1em; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 1em 0px 0px; PADDING-TOP: 0px } #ftr #footer-journal P.journal-name { FONT-WEIGHT: bold; FONT-SIZE: 100%; FONT-STYLE: italic } #ftr #footer-journal P.issn { FONT-SIZE: 100% } #ftr #footer-journal P.eissn { FONT-SIZE: 100% } #ftr #footer-journal P.extra { FONT-SIZE: 100% } #ftr #footer-links { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: #000; PADDING-BOTTOM: = 5px; PADDING-TOP: 5px } #ftr #footer-links UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #ftr #footer-links UL LI { DISPLAY: inline } #ftr #footer-links UL LI A:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #ftr #footer-links UL LI A:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #ftr #footer-links UL LI A:hover { TEXT-DECORATION: underline } #ftr #footer-links UL LI A.about-npg:link { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #ftr #footer-links UL LI A.about-npg:visited { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #ftr #footer-copyright { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left! important } #ftr #footer-copyright A { COLOR: #db1a21 } #ftr #footer-copyright P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 5px } #ftr #footer-copyright P.logo { PADDING-RIGHT: 36px; PADDING-LEFT: 36px; BACKGROUND: = url(/common/images/npg_logo.gif) no-repeat 0px 50%; PADDING-BOTTOM: 7px; = MARGIN: 5px 0px 0px; PADDING-TOP: 7px } #ftr #footer-copyright P A:link { FONT-WEIGHT: bold; TEXT-DECORATION: none } #ftr #footer-copyright P A:visited { FONT-WEIGHT: bold; TEXT-DECORATION: none } #ftr #footer-copyright P A.footer-copyright:link { FONT-WEIGHT: normal; COLOR: #000 } #ftr #footer-copyright P A.footer-copyright:visited { FONT-WEIGHT: normal; COLOR: #000 } #ftr #footer-copyright P A:hover { TEXT-DECORATION: underline } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/layout.css #header { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #breadcrumb { MARGIN-LEFT: 1%; MARGIN-RIGHT: 1% } #constrain { FLOAT: left } #constrain DIV.constrain { FLOAT: left } #constrain { FLOAT: none } #constrain DIV.constrain { FLOAT: none } #content-journalnav { BORDER-TOP: #fff 1px solid; DISPLAY: inline; FLOAT: left; MARGIN-LEFT: = 1%; WIDTH: 79% } #content-journalnav:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #content-journalnav { HEIGHT: 1% } #journalnav { FLOAT: left; WIDTH: 21% } #journalnav:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #journalnav { HEIGHT: 1% } #content { FLOAT: right; PADDING-BOTTOM: 1em; WIDTH: 76% } #content:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #content { HEIGHT: 1% } #extranav { BORDER-TOP: #fff 1px solid; DISPLAY: inline; FLOAT: right; WIDTH: 17%; = MARGIN-RIGHT: 1% } #extranav:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #extranav { HEIGHT: 1% } #footer { CLEAR: both; PADDING-RIGHT: 1%; BORDER-TOP: black 4px solid; = PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #footer-copyright { CLEAR: both; PADDING-RIGHT: 1%; BORDER-TOP: black 1px solid; = PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #footer-sponsor { CLEAR: both; PADDING-RIGHT: 1%; BORDER-TOP: black 1px solid; = PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: = center } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/main.css * HTML BODY { FONT-SIZE: 90% } * HTML BODY { FONT-SIZE: 89% } BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; BACKGROUND: = #fff; PADDING-BOTTOM: 20px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 0px; = FONT-FAMILY: Verdana, arial, Helvetica, sans-serif } A:link { COLOR: #36c } A:visited { COLOR: #639 } A:hover { COLOR: #c03 } .print-header { DISPLAY: none } .hidden { LEFT: 0px; OVERFLOW: hidden; WIDTH: 1px; POSITION: absolute; TOP: = -500px; HEIGHT: 1px } .clearfix:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML .clearfix { HEIGHT: 1% } DIV.cleardiv { CLEAR: both; PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! = important; PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } SPAN.cleardiv { CLEAR: both! important; PADDING-RIGHT: 0px! important; DISPLAY: block! = important; PADDING-LEFT: 0px! important; PADDING-BOTTOM: 0px! important; = MARGIN: 0px; PADDING-TOP: 0px! important } .no-css { DISPLAY: none; HEIGHT: 0px } #npglogo { MARGIN-LEFT: -34px; POSITION: relative; TOP: -10px } #npglogo { DISPLAY: block } HTML > BODY #npglogo { DISPLAY: none } HEAD:first-child + BODY #npglogo { DISPLAY: block } #npglogo IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; Z-INDEX: 1; = BORDER-BOTTOM-WIDTH: 0px; WIDTH: 26px; POSITION: absolute; TOP: 1em; = HEIGHT: 26px; BORDER-RIGHT-WIDTH: 0px } #accessibility-bar #npglogo A { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; = BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .button { FONT-WEIGHT: bold; FONT-SIZE: 80%; COLOR: #fff; BACKGROUND-COLOR: #000 } .clear { CLEAR: both } .clearleft { CLEAR: left } OL.decimal { LIST-STYLE-TYPE: decimal } OL.decimal-leading-zero { =09 } OL.lower-alpha { LIST-STYLE-TYPE: lower-alpha } OL.upper-alpha { LIST-STYLE-TYPE: upper-alpha } OL.lower-roman { LIST-STYLE-TYPE: lower-roman } OL.upper-roman { LIST-STYLE-TYPE: upper-roman } OL.lower-greek { =09 } .align-left { TEXT-ALIGN: left } .align-center { TEXT-ALIGN: center } .align-right { TEXT-ALIGN: right } .align-baseline { VERTICAL-ALIGN: baseline } .align-sub { VERTICAL-ALIGN: sub } .align-super { VERTICAL-ALIGN: super } .align-text-top { VERTICAL-ALIGN: text-top } .align-middle { VERTICAL-ALIGN: middle } .align-bottom { VERTICAL-ALIGN: bottom } .align-text-bottom { VERTICAL-ALIGN: text-bottom } A.seealso { MARGIN-TOP: 1em; DISPLAY: block; FONT-SIZE: 70%; TEXT-DECORATION: none } A.seealso SPAN.see { FONT-WEIGHT: bold; COLOR: #c03 } A.seealso SPAN.link { TEXT-DECORATION: underline } A.rss { PADDING-LEFT: 24px; BACKGROUND: url(/common/images/icons/rss.gif) = no-repeat left center } A.rss:hover { BACKGROUND: url(/common/images/icons/rss.gif) no-repeat left center } #extranav A.rss { PADDING-LEFT: 22px; BACKGROUND: url(/common/images/icons/newsfeeds.gif) = no-repeat left center; PADDING-BOTTOM: 2px; PADDING-TOP: 1px } #extranav A.receive { PADDING-LEFT: 22px; BACKGROUND: url(/common/images/icons/newsfeeds.gif) = no-repeat left center; PADDING-BOTTOM: 2px; PADDING-TOP: 1px } #content SPAN.free { COLOR: #c03; TEXT-DECORATION: none } .dev-error { FONT-WEIGHT: bold; FONT-SIZE: 80%; BACKGROUND: #f00; COLOR: #fff } .b { FONT-WEIGHT: bold } .i { FONT-STYLE: italic } .latin { FONT-STYLE: italic } H1.page-header { FONT-WEIGHT: bold; FONT-SIZE: 140%; PADDING-BOTTOM: 4px; MARGIN: 15px = 0px 10px; BORDER-BOTTOM: #eaeaea 1px solid } SPAN.page-header-spacer { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140%; VISIBILITY: hidden; = PADDING-BOTTOM: 4px; MARGIN: 15px 0px 0px } SPAN.booktitle { FONT-STYLE: italic } SPAN.journalname { FONT-STYLE: italic } SPAN.journalnumber { FONT-WEIGHT: bold } SPAN.tm { VERTICAL-ALIGN: super } LEGEND { COLOR: #000 } * HTML #breadcrumb DIV { MARGIN-TOP: 0px; PADDING-LEFT: 5px; PADDING-TOP: 1px } #breadcrumb DIV { CLEAR: left; MARGIN-TOP: 0px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 10px; PADDING-TOP: 1px } #breadcrumb DIV A:link { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:visited { FONT-SIZE: 70%; COLOR: #000; TEXT-DECORATION: none } #breadcrumb DIV A:hover { COLOR: #000; TEXT-DECORATION: underline } #breadcrumb SPAN.divider { FONT-SIZE: 70%; COLOR: #000 } #breadcrumb SPAN.thisitem { FONT-SIZE: 70%; COLOR: #000 } #login-inpage { MARGIN: 0px; COLOR: #000; BACKGROUND-COLOR: #eaeaea } #login-inpage A { FONT-SIZE: 70% } #login-inpage DIV.userpassbox { FLOAT: left; WIDTH: 8em } #login-inpage .passdetails { CLEAR: left } #login-inpage INPUT.text { FONT-SIZE: 80%; MARGIN: 0px; WIDTH: 9em; COLOR: #000 } #login-inpage LABEL { FONT-SIZE: 70% } #login-inpage INPUT.button { MARGIN-TOP: 5px } #login-inpage #savepass-inpage { MARGIN-BOTTOM: -2px } #login-inpage DIV.error { PADDING-LEFT: 20px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/login_error.gif) no-repeat 0px 4px; MARGIN-BOTTOM: = 5px; COLOR: #c30 } #login-inpage DIV.error SPAN { FONT-WEIGHT: bold } #head-er HR { DISPLAY: none } #head-er .header-nonad-wrapper { PADDING-BOTTOM: 15px; BORDER-BOTTOM: #fff 1px solid } #head-er .accessibility-login-wrap { FLOAT: left; WIDTH: 100%; BORDER-BOTTOM: #000 1px solid; = BACKGROUND-COLOR: #eaeaea } #head-er .accessibility-login { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 4px; TEXT-ALIGN: right } #head-er .accessibility-login A.nature-link { FLOAT: left; FONT: bold 160%/80% Garamond, serif; WIDTH: 4.9em; COLOR: = #b1062e; MARGIN-RIGHT: 20px; TEXT-ALIGN: left; TEXT-DECORATION: none } * HTML #head-er .accessibility-login A.nature-link:hover { BACKGROUND: none transparent scroll repeat 0% 0% } #head-er .accessibility-login A.nature-link:hover { BACKGROUND: = url(/common/includes/header/images/nature.com.underline.gif) no-repeat = left bottom } #head-er .accessibility-login IMG.nature-logo { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 1px 20px 0px 0px; WIDTH: 82px! = important; HEIGHT: 11px; BORDER-RIGHT-WIDTH: 0px } #head-er .accessibility-login .jumplinks { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 45%; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } #head-er .accessibility-login .jumplinks LI { DISPLAY: inline; PADDING-LEFT: 15px } #head-er .accessibility-login .jumplinks LI.first { PADDING-LEFT: 0px } #head-er .accessibility-login .jumplinks A { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/b1062e/arrow_down.gif) no-repeat left center; = COLOR: #000; TEXT-DECORATION: none } #head-er .accessibility-login .jumplinks A:hover { TEXT-DECORATION: underline } #head-er DIV.logon { =09 } #head-er .logon .onlyformacie { FONT-SIZE: 3px } #head-er .logon .onlyformacie { DISPLAY: none } #head-er .logon A.login { PADDING-RIGHT: 15px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logon.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon A.login:hover { BACKGROUND: url(/common/includes/header/images/logon_over.gif) = no-repeat right center; TEXT-DECORATION: underline } #head-er .logon A.login:active { BACKGROUND: url(/common/includes/header/images/logon.gif) no-repeat = right center } #head-er .logon A.logoff { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logoff.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon P { MARGIN: 0px } #head-er .logon .user { FONT-WEIGHT: bold } #head-er .logon .inst { FONT-WEIGHT: bold } #head-er .image-user-services-wrap { FLOAT: left; WIDTH: 100%; BACKGROUND-COLOR: #d6335c } #head-er .image-user-services { BORDER-BOTTOM: transparent 1px solid } * HTML #head-er .image-user-services { BORDER-BOTTOM-WIDTH: 0px } #head-er .image-user-services IMG.journal-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; WIDTH: 344px; HEIGHT: 74px; = BORDER-RIGHT-WIDTH: 0px } #head-er .user-services { FLOAT: right } #head-er .div1.user-services { WIDTH: 12.35em! important } #head-er .div2.user-services { WIDTH: 8.7em! important } #head-er .user-services UL { BORDER-RIGHT: #fff 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: #fff 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 22px 0px 21px; = BORDER-LEFT: #fff 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 0px = solid; LIST-STYLE-TYPE: none; TEXT-ALIGN: right } #head-er .user-services UL.list1 { BORDER-RIGHT: #fff 1px solid } #head-er .user-services LI { BORDER-BOTTOM: #fff 1px solid } #head-er .user-services A { PADDING-RIGHT: 13px; DISPLAY: block; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) #767474 no-repeat right = center; PADDING-BOTTOM: 1px; TEXT-TRANSFORM: uppercase; COLOR: #fff; = PADDING-TOP: 1px; TEXT-DECORATION: none } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .publications-search-wrap { BACKGROUND: #000 } * HTML #head-er .publications-search { PADDING-BOTTOM: 3px; PADDING-TOP: 3px } #head-er .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 4px; = PADDING-TOP: 4px } * HTML #head-er .publications { MARGIN: 6px 0px 0px } #head-er .publications { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4px 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #head-er .publications LI { DISPLAY: inline; MARGIN-LEFT: 10px } #head-er .publications LI.first { MARGIN-LEFT: 0px } #head-er .publications A { PADDING-RIGHT: 15px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .publications A:hover { TEXT-DECORATION: underline } #head-er .search { TEXT-ALIGN: right } #head-er .search FORM { DISPLAY: inline; MARGIN: 0px } #head-er .search FORM A { PADDING-RIGHT: 14px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .search FORM A:hover { TEXT-DECORATION: underline } #head-er #searchtext { WIDTH: 10em } #head-er .publications-search LABEL { TEXT-TRANSFORM: uppercase; COLOR: #fff } #head-er INPUT { FONT-SIZE: 100% } #head-er SELECT { FONT-SIZE: 100% } #head-er .publications-search INPUT.button { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px } #head-er .accessibility-login { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .image-user-services { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .publications-search { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } .header-leaderboard-wrap { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: = url(/common/includes/header/images/bg_leaderboard.gif) no-repeat 50% = 0px; OVERFLOW: hidden } .header-leaderboard { MAX-HEIGHT: 105px; TEXT-ALIGN: center } * HTML .header-leaderboard IMG { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard ilayer { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard IFRAME { BORDER-BOTTOM-WIDTH: 1px } * HTML .header-leaderboard EMBED { BORDER-BOTTOM-WIDTH: 1px } .header-leaderboard IMG { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard ilayer { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard IFRAME { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard EMBED { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; MAX-WIDTH: 728px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 1px solid; = HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .header-leaderboard TABLE { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; MAX-WIDTH: 728px; PADDING-BOTTOM: 0px; = MARGIN-LEFT: auto; WIDTH: 100%; MARGIN-RIGHT: auto; PADDING-TOP: 0px; = BORDER-BOTTOM: #fff 1px solid; BORDER-RIGHT-WIDTH: 0px } * HTML .header-leaderboard TABLE IMG { HEIGHT: auto } #constrain { MARGIN-TOP: 14px } #global-subject-areas { BORDER-RIGHT: #ebebeb 1px solid; BORDER-TOP: #ebebeb 1px solid; = BACKGROUND: #ebebeb; MARGIN: 0px 0px 20px; BORDER-LEFT: #ebebeb 1px = solid; BORDER-BOTTOM: #ebebeb 1px solid } #global-subject-areas ABBR { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px; TEXT-DECORATION: none } #global-subject-areas A:link { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:visited { FONT-WEIGHT: bold; COLOR: #9d0006; TEXT-DECORATION: none } #global-subject-areas A:hover { TEXT-DECORATION: underline } #global-subject-areas H2 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #global-subject-areas UL UL { FONT-SIZE: 100% } #global-subject-areas UL LI { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = LINE-HEIGHT: 150%; PADDING-TOP: 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL LI LI { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #global-subject-areas UL LI H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H5 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H6 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav { DISPLAY: block; MARGIN-BOTTOM: 20px } MAP.journal-nav UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } MAP.journal-nav UL LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } MAP.journal-nav UL LI.grouped { BORDER-BOTTOM: #eaeaea 1px solid } * HTML MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } * HTML MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 2px } MAP.journal-nav UL LI A { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:visited { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; FONT-SIZE: 80%; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 4px; TEXT-DECORATION: none } MAP.journal-nav UL LI A:hover { COLOR: #fff; BACKGROUND-COLOR: #c00; TEXT-DECORATION: none } MAP.journal-nav UL LI A.on { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.on:visited { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.submission { PADDING-LEFT: 20px! important; BACKGROUND: = url(/common/images/online_submissions.gif) no-repeat left center } MAP.journal-nav UL LI UL.subnav { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } MAP.journal-nav UL LI UL.subnav LI { BACKGROUND: url(/common/images/nav_dots2.gif) #fafafa no-repeat 11px = 5px; BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px } MAP.journal-nav UL LI UL.subnav LI.on { BACKGROUND: url(/common/images/nav_dots1.gif) #c00 no-repeat 11px 5px; = BORDER-BOTTOM: #fafafa 1px solid } * HTML MAP.journal-nav UL LI UL.subnav A { PADDING-RIGHT: 10px! important; PADDING-LEFT: 20px! important; = PADDING-BOTTOM: 2px! important; PADDING-TOP: 2px! important } MAP.journal-nav UL LI UL.subnav A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:hover { BACKGROUND: url(/common/images/nav_dots1.gif) #fab934 no-repeat 11px = 5px; COLOR: #fff; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A.on { COLOR: #fff } MAP.journal-nav UL LI UL.subnav A.on:visited { COLOR: #fff } #journalnav MAP.supplementary UL A { FONT-WEIGHT: normal; FONT-SIZE: 70% } #journalnav MAP.supplementary UL A:visited { FONT-WEIGHT: normal; FONT-SIZE: 70% } H2.society-resources { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #fab934 } UL.society-resources { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.society-resources LI { MARGIN: 0px; BACKGROUND-COLOR: #eaeaea } UL.society-resources A { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.society-resources A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.society-resources A:hover { COLOR: #fff; BACKGROUND-COLOR: #fab934; TEXT-DECORATION: none } DIV.society-logo { MARGIN-BOTTOM: 20px; TEXT-ALIGN: center } DIV.society-logo IMG { WIDTH: 100% } H2.npg-resources { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #b1062e } UL.npg-resources { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.npg-resources LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } UL.npg-resources A { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-resources A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-resources A:hover { COLOR: #fff; BACKGROUND-COLOR: #b1062e; TEXT-DECORATION: none } H2.npg-subjects { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #c03 } UL.npg-subjects { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.npg-subjects LI { MARGIN: 0px; BORDER-BOTTOM: #fff 1px solid; BACKGROUND-COLOR: #eaeaea } UL.npg-subjects A { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-subjects A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.npg-subjects A:hover { COLOR: #fff; BACKGROUND-COLOR: #c03; TEXT-DECORATION: none } UL.npg-subjects A.npgsubject-browseall:link { COLOR: #c03 } UL.npg-subjects A.npgsubject-browseall:visited { COLOR: #c03 } UL.npg-subjects A.npgsubject-browseall:hover { COLOR: #fff } A.backtotop:link { MARGIN-TOP: 5px; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_white_up.gif) no-repeat 0px 0.6em; FLOAT: = right; MARGIN-LEFT: 7px; COLOR: #fff; MARGIN-RIGHT: 10px } A.backtotop:visited { MARGIN-TOP: 5px; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_white_up.gif) no-repeat 0px 0.6em; FLOAT: = right; MARGIN-LEFT: 7px; COLOR: #fff; MARGIN-RIGHT: 10px } A.backtotop:hover { COLOR: #fff } H1.page { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #fab934; PADDING-BOTTOM: 3px; MARGIN: 0px 0px 10px; = COLOR: #fff; PADDING-TOP: 3px } IMG.arrow { MARGIN-RIGHT: 5px } A.arrow-blue { PADDING-LEFT: 10px; BACKGROUND: url(/common/images/arrow_blue.gif) = no-repeat 0px 0.5em } A.arrow-grey { PADDING-LEFT: 10px; BACKGROUND: url(/common/images/arrow_grey.gif) = no-repeat 0px 0.5em } A.arrow-red { PADDING-LEFT: 10px; BACKGROUND: url(/common/images/arrow_red.gif) = no-repeat 0px 0.5em } DIV.research-reviews { BORDER-RIGHT: #eaeaea 1px solid; BORDER-TOP: #eaeaea 1px solid; = MARGIN-BOTTOM: 2em; BORDER-LEFT: #eaeaea 1px solid; BORDER-BOTTOM: = #eaeaea 1px solid } DIV.research-reviews H1 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 90%; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 4px; MARGIN: 0px; COLOR: #900; PADDING-TOP: 3px } DIV.research-reviews P { FONT-SIZE: 70%; MARGIN: 1em 10px; COLOR: #900 } DIV.research-reviews UL { PADDING-RIGHT: 0px; BORDER-TOP: #eaeaea 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px 10px 1em; PADDING-TOP: 1em; = LIST-STYLE-TYPE: none } DIV.research-reviews LI { MARGIN: 0px 0px 0.5em } DIV.research-reviews LI A { FONT-WEIGHT: bold; FONT-SIZE: 90% } DIV.research-reviews LI SPAN { FONT-SIZE: 70% } DIV.ad-horiz { CLEAR: both; BORDER-TOP: #eaeaea 1px solid; FONT-SIZE: 70%; = MARGIN-BOTTOM: 20px; COLOR: #ccc; PADDING-TOP: 10px; TEXT-ALIGN: center } DIV.ad-horiz IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 468px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 60px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-horiz EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 468px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 60px; BORDER-RIGHT-WIDTH: 0px } * HTML DIV.ad-horiz { MAX-WIDTH: 468px! important; MARGIN-LEFT: auto; OVERFLOW: hidden; = WIDTH: 100%; MARGIN-RIGHT: auto } #extranav A.topten:link { PADDING-RIGHT: 0px; BORDER-TOP: #eaeaea 1px solid; MARGIN-TOP: 0.6em; = DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat 0px 1.2em; PADDING-BOTTOM: = 0px; PADDING-TOP: 0.8em } #extranav A.topten:visited { PADDING-RIGHT: 0px; BORDER-TOP: #eaeaea 1px solid; MARGIN-TOP: 0.6em; = DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat 0px 1.2em; PADDING-BOTTOM: = 0px; PADDING-TOP: 0.8em } #extranav A.topten:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat 0px 1.2em; = TEXT-DECORATION: underline } DIV.ad-vert { FONT-SIZE: 70%; MARGIN-BOTTOM: 20px; COLOR: #ccc; TEXT-ALIGN: center } DIV.ad-vert IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 120px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 600px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-vert EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 120px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 600px; BORDER-RIGHT-WIDTH: 0px } * HTML DIV.ad-vert { MAX-WIDTH: 160px! important; MARGIN-LEFT: auto; OVERFLOW: hidden; = WIDTH: 100%; MARGIN-RIGHT: auto } .ad120x90 { CLEAR: both; FONT-SIZE: 80%; BACKGROUND: #fff; COLOR: #ccc; TEXT-ALIGN: = center } .ad120x90 IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; = BORDER-BOTTOM-WIDTH: 0px; MAX-WIDTH: 120px! important; MARGIN: 7px 0px; = WIDTH: 100%; HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .ad120x90 EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; = BORDER-BOTTOM-WIDTH: 0px; MAX-WIDTH: 120px! important; MARGIN: 7px 0px; = WIDTH: 100%; HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .box#natjob { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 6px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 6px; BACKGROUND: #fff; PADDING-BOTTOM: = 6px; MARGIN: 10px 0px; OVERFLOW: hidden; BORDER-LEFT: #e7e7e7 1px solid; = COLOR: #000; PADDING-TOP: 6px; BORDER-BOTTOM: #e7e7e7 1px solid } H2.natjob { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; FONT-SIZE: 120%; BACKGROUND: = #d8d8d8; PADDING-BOTTOM: 5px; MARGIN: 0px 0px 0.75em; TEXT-TRANSFORM: = lowercase; PADDING-TOP: 5px; LETTER-SPACING: -0.04em } H2.natjob A { TEXT-DECORATION: none } H2.natjob SPAN.first { COLOR: #f00 } H2.natjob SPAN.second { COLOR: #000 } UL.natjob { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none } UL.natjob H3 { FONT-WEIGHT: bold; FONT-SIZE: 110%; MARGIN: 10px 0px 0px } UL.natjob H3.first { MARGIN: 0px } UL.natjob H3 A:link { COLOR: #000; TEXT-DECORATION: underline! important } UL.natjob H3 A:visited { COLOR: #000; TEXT-DECORATION: underline! important } UL.natjob LI H3 A:hover { COLOR: #c03 } UL.natjob LI H3 A:focus { COLOR: #c03 } * HTML UL.natjob UL { LINE-HEIGHT: 120% } DIV.natjobmore { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-SIZE: 110%; PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: 5px } DIV.natjobmore A:link { DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/next.gif) no-repeat 0px 0.3em; MARGIN: 0px; = COLOR: #c03; TEXT-DECORATION: none } DIV.natjobmore A:visited { DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/next.gif) no-repeat 0px 0.3em; MARGIN: 0px; = COLOR: #c03; TEXT-DECORATION: none } .box#natjob DIV.natjobmore A:hover { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); = TEXT-DECORATION: underline } .box#natjob DIV.natjobmore A:focus { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); = TEXT-DECORATION: underline } UL.natjob UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } P.natjobmore { PADDING-BOTTOM: 5px; MARGIN: 0px } P.nateventmore { PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: 5px } .box#natprod { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 6px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 6px; BACKGROUND: #fff; PADDING-BOTTOM: = 6px; MARGIN: 10px 0px; BORDER-LEFT: #e7e7e7 1px solid; COLOR: #000; = PADDING-TOP: 6px; BORDER-BOTTOM: #e7e7e7 1px solid } H2.natprod { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; FONT-SIZE: 120%; BACKGROUND: = #d8d8d8; PADDING-BOTTOM: 5px; MARGIN: 0px 0px 0.75em; TEXT-TRANSFORM: = lowercase; PADDING-TOP: 5px; LETTER-SPACING: -0.04em } H2.natprod A { TEXT-DECORATION: none } H2.natprod SPAN.first { COLOR: #f00 } H2.natprod SPAN.second { COLOR: #000 } .box#natprod FORM { MARGIN: 0px } DIV.natprod { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 4px; PADDING-LEFT: 4px; = BACKGROUND: #f3f2f2; PADDING-BOTTOM: 4px; BORDER-LEFT: black 1px solid; = PADDING-TOP: 4px; BORDER-BOTTOM: black 1px solid } DIV.natprodmore { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0.75em; = PADDING-TOP: 0px } DIV.natprodmore A:link { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: none } DIV.natprodmore A:visited { DISPLAY: block; PADDING-LEFT: 7px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_red.gif) no-repeat 0px 0.5em; COLOR: #c03; = TEXT-DECORATION: none } DIV.natprodmore A:focus { TEXT-DECORATION: underline } DIV.natprodmore A:hover { TEXT-DECORATION: underline } DIV.natprod SPAN { DISPLAY: block; FONT-SIZE: 70%; MARGIN-BOTTOM: 10px; LINE-HEIGHT: 110% } #natprod FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.natprodmore FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.natprodmore INPUT { MARGIN-TOP: 5px; FONT-SIZE: 110%; WIDTH: 98%! important } * HTML DIV.natprodmore INPUT { WIDTH: 96%! important } DIV.natprodmore INPUT { WIDTH: 80% } DIV.natprodmore INPUT { WIDTH: 100% } DIV.natprodmore INPUT.button { FONT-WEIGHT: bold; COLOR: #fff; BACKGROUND-COLOR: #000 } #article-related #journal-header { DISPLAY: none } #article-related H2.atl { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article-related H2.figure-title { CLEAR: both; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related P.from { FONT-WEIGHT: bold; FONT-SIZE: 70%; MARGIN: 0px; COLOR: #c03 } #article-related P.aug { FONT-SIZE: 70%; MARGIN: 0px } #article-related A.back-to-article:link { CLEAR: both; PADDING-RIGHT: 1em; PADDING-LEFT: 1em; FONT-WEIGHT: bold; = FONT-SIZE: 70%; BACKGROUND: #000; FLOAT: right; PADDING-BOTTOM: 3px; = MARGIN: 10px 0px; COLOR: #fff; PADDING-TOP: 3px; TEXT-DECORATION: none } #article-related A.back-to-article:visited { CLEAR: both; PADDING-RIGHT: 1em; PADDING-LEFT: 1em; FONT-WEIGHT: bold; = FONT-SIZE: 70%; BACKGROUND: #000; FLOAT: right; PADDING-BOTTOM: 3px; = MARGIN: 10px 0px; COLOR: #fff; PADDING-TOP: 3px; TEXT-DECORATION: none } #article-related A.back-to-article:hover { BACKGROUND: #fab934; COLOR: #fff; TEXT-DECORATION: none } #article-related DIV.container-image { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: #eaeaea; PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; = PADDING-TOP: 10px; TEXT-ALIGN: center } #article-related DIV.container-image-text { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: #eaeaea; PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; = PADDING-TOP: 10px } #article-related DIV.container-image-text P { FONT-SIZE: 90% } #article-related FORM { MARGIN: 0px } #article-related DIV.container-image-text UL { FONT-SIZE: 90% } #article-related DIV.container-image-text OL { FONT-SIZE: 90% } #article-related DIV.prevnext { CLEAR: both; BORDER-RIGHT: black 1px solid; BORDER-TOP: black 1px = solid; BACKGROUND: #fff; BORDER-LEFT: black 1px solid; BORDER-BOTTOM: = black 1px solid; TEXT-ALIGN: center } #article-related DIV.prevnext .hide { DISPLAY: none } #article-related DIV.prevnext A { FONT: 70% verdana, arial, helvetica, sans-serif; TEXT-DECORATION: none } #article-related A.previous:link { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: url(/common/images/arrow_blue_left.gif) no-repeat left = center; FLOAT: left; PADDING-BOTTOM: 2px; MARGIN-LEFT: 10px; = PADDING-TOP: 2px } #article-related A.previous:visited { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 10px; PADDING-LEFT: 10px; = BACKGROUND: url(/common/images/arrow_blue_left.gif) no-repeat left = center; FLOAT: left; PADDING-BOTTOM: 2px; MARGIN-LEFT: 10px; = PADDING-TOP: 2px } #article-related A.previous:hover { BACKGROUND: url(/common/images/arrow_red_left.gif) no-repeat left = center } #article-related A.index:link { PADDING-RIGHT: 5px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue_up.gif) no-repeat left center; = PADDING-BOTTOM: 2px; VERTICAL-ALIGN: middle; PADDING-TOP: 2px } #article-related A.index:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue_up.gif) no-repeat left center; = PADDING-BOTTOM: 2px; VERTICAL-ALIGN: middle; PADDING-TOP: 2px } #article-related A.index:hover { BACKGROUND: url(/common/images/arrow_red_up.gif) no-repeat left center } #article-related A.next:link { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat right center; FLOAT: right; = PADDING-BOTTOM: 2px; BORDER-LEFT: black 1px solid; MARGIN-RIGHT: 10px; = PADDING-TOP: 2px } #article-related A.next:visited { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat right center; FLOAT: right; = PADDING-BOTTOM: 2px; BORDER-LEFT: black 1px solid; MARGIN-RIGHT: 10px; = PADDING-TOP: 2px } #article-related A.next:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat right center } #article-related DIV.container-figtab { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 0px solid } #article-related DIV.last { BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-figtab DIV.container-image IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 150px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-figtab DIV.container-image { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; FLOAT: left; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; WIDTH: = 150px; PADDING-TOP: 0px; TEXT-ALIGN: right; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-figtab DIV.container-image-text { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: none transparent scroll repeat 0% = 0%; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN-LEFT: 160px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.container-figtab DIV.container-image-text H3 { FONT-SIZE: 90%; MARGIN: 0px } #article-related DIV.container-figtab DIV.container-image-text P { FONT-SIZE: 90%; MARGIN: 0px } #article-related DIV.container-figtab A.full { MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: 25px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/full_figure.gif) no-repeat 0px 0px } #article-related DIV.container-figtab A.pdb { MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: 25px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/icons/pdb_small.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 3px } #article-related DIV.container-figtab A.threed-view { MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: 25px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/icons/threed_small.gif) no-repeat 0px = 0px; PADDING-BOTTOM: 3px } #article-related DIV.container-figtab A.pp { PADDING-RIGHT: 0px; MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: = 25px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/icons/fff/powerpoint.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 4px; PADDING-TOP: 0px } #article-related DIV.container-supplementary { CLEAR: both; BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 0px; = PADDING-LEFT: 0px; BACKGROUND: #eaeaea; PADDING-BOTTOM: 0px; = BORDER-LEFT: black 1px solid; PADDING-TOP: 0px } #article-related A.download-plugins:link { CLEAR: both; BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 0px; = BORDER-TOP: black 1px solid; DISPLAY: block; PADDING-LEFT: 17px; = FONT-SIZE: 70%; BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat = 10px 0.45em; PADDING-BOTTOM: 3px; BORDER-LEFT: black 1px solid; = PADDING-TOP: 0px; BORDER-BOTTOM: black 1px solid } #article-related A.download-plugins:visited { CLEAR: both; BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 0px; = BORDER-TOP: black 1px solid; DISPLAY: block; PADDING-LEFT: 17px; = FONT-SIZE: 70%; BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat = 10px 0.45em; PADDING-BOTTOM: 3px; BORDER-LEFT: black 1px solid; = PADDING-TOP: 0px; BORDER-BOTTOM: black 1px solid } #article-related A.download-plugins:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat 10px 0.45em } #article-related DIV.container-supplementary H2 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 10px } #article-related DIV.container-supplementary P { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 90%; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 0px; BORDER-BOTTOM: = black 1px solid } #article-related DIV.container-supplementary P.last { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 0px } #article-related DIV.container-sendfriend { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-plugins { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { CLEAR: both; BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #000 1px solid; PADDING-LEFT: 10px; BACKGROUND: #eaeaea; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid } #article-related DIV.container-more2 { BORDER-BOTTOM-WIDTH: 0px } #article-related DIV.wrapper { MARGIN-BOTTOM: 10px } #article-related P.explain { FONT-SIZE: 70%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related DIV.container-plugins P.last { MARGIN: 0px } #article-related P.results { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #article-related A.article { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article-related P.journal { FONT-SIZE: 70%; MARGIN: 0px } #article-related DIV.container-more2 P.journal { MARGIN-BOTTOM: 1em } #article-related H3.area { FONT-WEIGHT: normal; FONT-SIZE: 70%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase } #article-related A.allmatches:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related A.allmatches:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related A.allmatches:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat left center } #article-related DIV.text { FLOAT: left; WIDTH: 210px; TEXT-ALIGN: right } #article-related DIV.text LABEL { FONT-WEIGHT: bold; FONT-SIZE: 90% } #article-related DIV.text P { FONT-SIZE: 70%; MARGIN: 0px } #article-related DIV.form { MARGIN-LEFT: 220px } #article-related DIV.form INPUT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.form TEXTAREA { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto; PADDING-TOP: 0px } #article-related DIV.form INPUT { WIDTH: 100% } #article-related DIV.form TEXTAREA { WIDTH: 100% } #article-related INPUT.friend { CLEAR: both; FLOAT: right } * HTML #article-related TABLE.data { FONT-SIZE: 100% } #article-related TABLE.data { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: = #999 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #999 1px solid; = BORDER-COLLAPSE: collapse; TEXT-ALIGN: left } #article-related TABLE.data THEAD { FONT-WEIGHT: bold } #article-related TABLE.data THEAD TH { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0.5em; PADDING-LEFT: = 0.5em; FONT-SIZE: 90%; BACKGROUND: #f6f6f6; PADDING-BOTTOM: 0.5em; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 0px } #article-related TABLE.data THEAD TH.colspan { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 0px solid; BORDER-LEFT: = #999 1px solid; BORDER-BOTTOM: #999 1px solid; TEXT-ALIGN: center } #article-related TABLE.data THEAD TH.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.rowsep { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data THEAD TH.rowsep { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY { BORDER-TOP: #999 1px solid; BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TR { BACKGROUND-COLOR: #f6f6f6 } #article-related TABLE.data TBODY TR.odd { BACKGROUND-COLOR: #fff } #article-related TABLE.data TBODY TD { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0.5em; PADDING-LEFT: = 0.5em; FONT-SIZE: 90%; PADDING-BOTTOM: 0.15em; PADDING-TOP: 0.15em } #article-related TABLE.data TFOOT TD { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; FONT-SIZE: 90%; = PADDING-BOTTOM: 0.5em; PADDING-TOP: 0.5em; BACKGROUND-COLOR: #fff } #foot-er { BORDER-TOP-WIDTH: 0px; CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 20px 0px; PADDING-TOP: 0px } #foot-er #footer-journal { PADDING-RIGHT: 1%; BORDER-TOP: #000 1px solid; PADDING-LEFT: 1%; = BACKGROUND: #eee; PADDING-BOTTOM: 2px; PADDING-TOP: 2px } #foot-er #footer-journal:unknown { CLEAR: both; DISPLAY: block; VISIBILITY: hidden; HEIGHT: 0px; content: = url(/common/images/clear.gif) } * HTML #foot-er #footer-journal { HEIGHT: 1% } #foot-er #footer-journal P { PADDING-RIGHT: 1em; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 1em 0px 0px; PADDING-TOP: 0px } #foot-er #footer-journal P.journal-name { FONT-WEIGHT: bold; FONT-SIZE: 100%; FONT-STYLE: italic } #foot-er #footer-journal P.issn { FONT-SIZE: 100% } #foot-er #footer-journal P.eissn { FONT-SIZE: 100% } #foot-er #footer-journal P.extra { FONT-SIZE: 100% } #foot-er #footer-links { PADDING-RIGHT: 1%; PADDING-LEFT: 1%; BACKGROUND: #000; PADDING-BOTTOM: = 5px; PADDING-TOP: 5px } #foot-er #footer-links UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #foot-er #footer-links UL LI { DISPLAY: inline } #foot-er #footer-links UL LI A:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } #foot-er #footer-links UL LI A:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 1em; BACKGROUND: = #000; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1em; = BORDER-LEFT: #fff 1px solid; COLOR: #fff; PADDING-TOP: 0px; = TEXT-DECORATION: none } * HTML #foot-er #footer-links UL LI A:link { DISPLAY: inline } * HTML #foot-er #footer-links UL LI A:visited { DISPLAY: inline } #foot-er #footer-links UL LI A:hover { TEXT-DECORATION: underline } #foot-er #footer-links UL LI A.about-npg:link { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-links UL LI A.about-npg:visited { PADDING-LEFT: 0px; FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; = MARGIN-LEFT: 0px } #foot-er #footer-copyright { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left! important } * HTML #foot-er #footer-copyright .footer-constrain { TEXT-ALIGN: left } #foot-er #footer-copyright A { COLOR: #b1062e } #foot-er #footer-copyright P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 5px } #foot-er #footer-copyright P.logo { PADDING-RIGHT: 36px; PADDING-LEFT: 36px; BACKGROUND: = url(/common/images/npg_logo.gif) no-repeat 0px 50%; PADDING-BOTTOM: 7px; = MARGIN: 5px 0px 0px; PADDING-TOP: 7px } #foot-er #footer-copyright P A:link { FONT-WEIGHT: bold; TEXT-DECORATION: none } #foot-er #footer-copyright P A:visited { FONT-WEIGHT: bold; TEXT-DECORATION: none } #foot-er #footer-copyright P A.footer-copyright:link { FONT-WEIGHT: normal; COLOR: #000 } #foot-er #footer-copyright P A.footer-copyright:visited { FONT-WEIGHT: normal; COLOR: #000 } #foot-er #footer-copyright P A:hover { TEXT-DECORATION: underline } #content .scp { FONT-VARIANT: small-caps } DIV.ab-ad { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; BACKGROUND: #eaeaea; = MARGIN-BOTTOM: 15px; PADDING-BOTTOM: 3px; PADDING-TOP: 0px; TEXT-ALIGN: = center } DIV.ab-ad H2.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H4.head-main { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #ccc } DIV.ab-ad H3.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H5.head-supported { FONT-WEIGHT: normal; FONT-SIZE: 100%; MARGIN: 5px 0px 0px; COLOR: #000 } DIV.ab-ad H4.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H6.head-products { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 100%; BACKGROUND: #e0ebf9; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: = #333; PADDING-TOP: 5px } DIV.ab-ad H5.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad H6.head-section { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; COLOR: #0068b3 } DIV.ab-ad DIV.container { BORDER-RIGHT: #e0ebf9 1px solid; BORDER-TOP: #e0ebf9 1px solid; = MARGIN-TOP: 3px; BORDER-LEFT: #e0ebf9 1px solid; BORDER-BOTTOM: #e0ebf9 = 1px solid; BACKGROUND-COLOR: #fff } DIV.ab-ad UL { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #fff; = PADDING-BOTTOM: 5px; MARGIN: 0px; TEXT-TRANSFORM: none; PADDING-TOP: = 5px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } DIV.ab-ad UL UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } DIV.ab-ad LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: = 0px; PADDING-TOP: 2px } DIV.ab-ad A { COLOR: #0068b3 } DIV.ab-ad A.sponsor IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 118px; WIDTH: 100%; BORDER-RIGHT-WIDTH: 0px } DIV.ab-ad P.blurb { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 5px 5px; PADDING-TOP: 0px; TEXT-ALIGN: left } .eotm-jotw { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: 0px = 0px 20px; OVERFLOW: hidden; BORDER-LEFT: #e7e7e7 1px solid; PADDING-TOP: = 0px; BORDER-BOTTOM: #e7e7e7 1px solid; LIST-STYLE-TYPE: none; = BACKGROUND-COLOR: #fff } .eotm-jotw .main-heading { PADDING-RIGHT: 10px; PADDING-LEFT: 48px; FONT-SIZE: 110%; BACKGROUND: = url(/common/images/eotm_jotw_bg.jpg) no-repeat 0px 0px; PADDING-BOTTOM: = 10px; MARGIN: 0px; PADDING-TOP: 10px } .eotm-jotw .main-heading .type { DISPLAY: block; COLOR: #f00 } .eotm-jotw .main-heading .timeframe { FONT-WEIGHT: normal; FONT-SIZE: 100% } .eotm-jotw .main-heading .job-or-event { TEXT-TRANSFORM: uppercase } .eotm-jotw .events-jobs { PADDING-RIGHT: 8px; PADDING-LEFT: 8px; PADDING-BOTTOM: 0px; MARGIN: = -70px 0px 0px; PADDING-TOP: 70px; LIST-STYLE-TYPE: none } .jotw .events-jobs { BACKGROUND: url(/common/images/jotw.gif) no-repeat 10px 30px } .eotm .events-jobs { BACKGROUND: url(/common/images/eotm.gif) no-repeat 10px 30px } .eotm-jotw .title { FONT-SIZE: 100%; MARGIN: 10px 0px 0px } .eotm-jotw .events-jobs P { FONT-SIZE: 100%; MARGIN: 0px 0px 10px } .eotm-jotw .events-jobs P SPAN { FONT-WEIGHT: bold } .eotm-jotw .more { CLEAR: both; PADDING-RIGHT: 8px; DISPLAY: block; PADDING-LEFT: 15px; = BACKGROUND: url(/common/images/icons/next.gif) no-repeat 0px 0.6ex; = MARGIN: 10px 0px 0px 8px; LINE-HEIGHT: 110%; TEXT-DECORATION: none } .eotm-jotw .more .link { FONT-SIZE: 100%; TEXT-DECORATION: underline } .eotm-jotw .site { MARGIN-TOP: 0.5ex; DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; = COLOR: #444; FONT-FAMILY: Georgia, serif; LETTER-SPACING: -0.04em } .eotm-jotw .site .nature { COLOR: #f33 } INPUT.sermo-submit { PADDING-RIGHT: 0px; BACKGROUND-POSITION: 6px center; DISPLAY: block; = PADDING-LEFT: 10%; FONT-SIZE: 100%; PADDING-BOTTOM: 5px; MARGIN: 0px; = WIDTH: 100%; CURSOR: pointer; COLOR: #000; BORDER-TOP-STYLE: none; = PADDING-TOP: 5px; BACKGROUND-REPEAT: no-repeat; FONT-FAMILY: = Verdana,arial,Helvetica,sans-serif; BORDER-RIGHT-STYLE: none; = BORDER-LEFT-STYLE: none; BACKGROUND-COLOR: #f3f3f3; TEXT-ALIGN: left; = BORDER-BOTTOM-STYLE: none } INPUT.sermo-submit:hover { BACKGROUND-COLOR: #eaeaea! important } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/style/header_footer_smallfonts.css #head-er .accessibility-login A.nature-link { FONT: bold 110%/80% Garamond, serif; WIDTH: 5em } #global-subject-areas H2 { FONT-SIZE: 80% } #global-subject-areas H3 { FONT-SIZE: 80% } #global-subject-areas H4 { FONT-SIZE: 80% } #global-subject-areas H5 { FONT-SIZE: 80% } DIV.ab-ad { FONT-SIZE: 70% } #global-subject-areas H3.view { FONT-SIZE: 70% } #global-subject-areas H4.view { FONT-SIZE: 70% } #global-subject-areas H5.view { FONT-SIZE: 70% } #global-subject-areas UL { FONT-SIZE: 70% } #head-er .accessibility-login .jumplinks { FONT-SIZE: 70% } #head-er DIV.logon { FONT-SIZE: 70% } #head-er .user-services { FONT-SIZE: 70% } #head-er .publications { FONT-SIZE: 70% } #head-er .search FORM A { FONT-SIZE: 70% } #head-er .publications-search LABEL { FONT-SIZE: 70% } #head-er INPUT { FONT-SIZE: 70% } #head-er SELECT { FONT-SIZE: 70% } #foot-er { FONT-SIZE: 70% } .box#natjob H2.natjob { FONT-SIZE: 90% } .box#natprod H2.natprod { FONT-SIZE: 90% } .box#natjob UL.natjob LI H3 { FONT-SIZE: 80% } .box#natjob DIV.natjobmore { FONT-SIZE: 80% } .box#natprod DIV.natprodmore INPUT { FONT-SIZE: 80% } UL.natjob UL { FONT-SIZE: 70% } .eotm-jotw .main-heading { FONT-SIZE: 90% } .eotm-jotw .main-heading .timeframe { FONT-SIZE: 80% } .eotm-jotw .title { FONT-SIZE: 80% } .eotm-jotw .events-jobs P { FONT-SIZE: 80% } .eotm-jotw .more .link { FONT-SIZE: 80% } .eotm-jotw .site { FONT-SIZE: 80% } .eotm-jotw .more { LINE-HEIGHT: 82% } .global-message H1 { FONT-SIZE: 100% } DIV.minimised.global-message H1 { FONT-SIZE: 80% } .global-message .content P { FONT-SIZE: 80% } .message-control A { FONT-SIZE: 80% } DIV.visible.global-message .message-control { WIDTH: 14em } DIV.minimised.global-message .message-control { WIDTH: 10em } INPUT.sermo-submit { FONT-SIZE: 80% } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/clinicalpractice/style/layout_group.css #content-extranav { DISPLAY: inline; FLOAT: right; WIDTH: 80%; MARGIN-RIGHT: 1% } #journalnav { DISPLAY: inline; FLOAT: left; MARGIN-LEFT: 1%; WIDTH: 16% } #content { BORDER-TOP: #fff 1px solid; FLOAT: left; MARGIN: 0px 0px 1em; WIDTH: 69% } #extranav { FLOAT: right; MARGIN: 0px; WIDTH: 28% } .smtext { FONT-SIZE: 70% } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/clinicalpractice/style/group.css A { COLOR: #00c } A:visited { COLOR: #639 } A:hover { COLOR: #c33 } BODY#article DIV#content DIV#References OL { LIST-STYLE-TYPE: decimal } #content UL { FONT-SIZE: 90%; LINE-HEIGHT: 100% } A.backtotop:link { BACKGROUND: url(/common/images/arrow_black_up.gif) no-repeat 0px 0.6em; = COLOR: #000; MARGIN-RIGHT: 0px; TEXT-DECORATION: none } A.backtotop:visited { BACKGROUND: url(/common/images/arrow_black_up.gif) no-repeat 0px 0.6em; = COLOR: #000; MARGIN-RIGHT: 0px; TEXT-DECORATION: none } A.backtotop:hover { TEXT-DECORATION: underline } .button { BORDER-TOP-WIDTH: 1px; BORDER-LEFT-WIDTH: 1px; BORDER-LEFT-COLOR: #000; = BORDER-BOTTOM-WIDTH: 1px; BORDER-BOTTOM-COLOR: #000; BORDER-TOP-COLOR: = #000; BACKGROUND-COLOR: #0066b3; BORDER-RIGHT-WIDTH: 1px; = BORDER-RIGHT-COLOR: #000 } #header-login { BACKGROUND: #fff; BORDER-BOTTOM: #ccc 1px solid } #logged-in { BORDER-LEFT-WIDTH: 0px; BACKGROUND-COLOR: #f6f6f6; BORDER-RIGHT-WIDTH: = 0px } #login { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BACKGROUND-COLOR: #f6f6f6; BORDER-RIGHT-WIDTH: 0px } #login A:link { COLOR: #000 } #login A:visited { COLOR: #000 } #login A:hover { COLOR: #0066b3 } #search-button { BORDER-BOTTOM: #808080 1px solid } * HTML #header #search-button { MARGIN-BOTTOM: 15px } #header #search-button { MARGIN-BOTTOM: 15px } DIV.account-buttons SPAN.hidden { DISPLAY: inline; LEFT: 0px; WIDTH: auto; COLOR: #808080; POSITION: = relative; TOP: 0px; HEIGHT: auto } DIV.account-buttons A:link { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0.2em; PADDING-LEFT: 0.2em; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; = BACKGROUND-COLOR: #fff; BORDER-RIGHT-WIDTH: 0px } DIV.account-buttons A:visited { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0.2em; PADDING-LEFT: 0.2em; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; = BACKGROUND-COLOR: #fff; BORDER-RIGHT-WIDTH: 0px } DIV.account-buttons A:hover { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; COLOR: #0066b3; BACKGROUND-COLOR: #fff; BORDER-RIGHT-WIDTH: 0px } #search A.adsearch:link { COLOR: #000 } #search A.adsearch:visited { COLOR: #000 } #search A.adsearch:hover { COLOR: #0066b3 } .special-cme { PADDING-LEFT: 35px! important; BACKGROUND: = url(/clinicalpractice/images/cme_small.gif) no-repeat 0px 15px } .special-ebm { PADDING-LEFT: 35px! important; BACKGROUND: = url(/clinicalpractice/images/ebm_small.gif) no-repeat 0px 15px } .special-free { PADDING-LEFT: 35px! important; BACKGROUND: = url(/clinicalpractice/images/free_small.gif) no-repeat 0px 15px } DIV.ad-vert IMG { MAX-WIDTH: 160px! important } DIV.ad-vert EMBED { MAX-WIDTH: 160px! important } DIV.ad-rh { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 20px 0px; PADDING-TOP: 10px; TEXT-ALIGN: center } DIV.ad-rh P { FONT-SIZE: 70%; MARGIN: 0px; COLOR: #999 } DIV.skyscraper IMG { WIDTH: 100%; HEIGHT: 600px } DIV.skyscraper EMBED { WIDTH: 100%; HEIGHT: 600px } DIV.skyscraper IFRAME { WIDTH: 100%; HEIGHT: 600px } DIV.wide.skyscraper IMG { MAX-WIDTH: 160px } DIV.wide.skyscraper EMBED { MAX-WIDTH: 160px } DIV.wide.skyscraper IFRAME { MAX-WIDTH: 160px } * HTML DIV.skyscraper { MARGIN-LEFT: auto; OVERFLOW: hidden; MARGIN-RIGHT: auto } MAP.journal-nav UL LI A { FONT-WEIGHT: normal; BORDER-BOTTOM: #d3d3d3 1px solid } MAP.journal-nav UL LI A:visited { FONT-WEIGHT: normal; BORDER-BOTTOM: #d3d3d3 1px solid } MAP.journal-nav UL LI A:hover { BACKGROUND-COLOR: #0066b3 } MAP.journal-nav UL LI A.on { BACKGROUND-COLOR: #0066b3 } MAP.journal-nav UL LI A.on:visited { BACKGROUND-COLOR: #0066b3 } MAP.journal-nav UL LI { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MARGIN-BOTTOM: 1px; BACKGROUND-COLOR: #f6f6f6; BORDER-RIGHT-WIDTH: = 0px } MAP.journal-nav UL LI A.on { BORDER-BOTTOM: #025390 1px solid } MAP.journal-nav UL LI A:hover { BORDER-BOTTOM: #025390 1px solid } MAP.journal-nav UL LI UL.subnav { BORDER-BOTTOM: #bfd9ec 1px solid } MAP.journal-nav UL LI UL.subnav LI { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #e5eff7 no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav UL LI UL.subnav LI A { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #e5eff7 no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav UL LI UL.subnav LI.on { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #0066b3 no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav UL LI UL.subnav LI.on A { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #0066b3 no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav UL LI UL.subnav A:link { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 5px! important; PADDING-LEFT: = 15px! important; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important; = BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav UL LI UL.subnav A:visited { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 5px! important; PADDING-LEFT: = 15px! important; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important; = BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav UL LI UL.subnav LI A:hover { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #0066b3 no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; BORDER-RIGHT-WIDTH: 0px } H2.npg-resources { FONT-WEIGHT: normal; TEXT-TRANSFORM: uppercase; COLOR: #000; = BACKGROUND-COLOR: #f6f6f6 } UL.npg-resources { BORDER-RIGHT: #f6f6f6 1px solid; BORDER-LEFT: #f6f6f6 1px solid; = BORDER-BOTTOM: #d3d3d3 1px solid } * HTML UL.npg-resources LI { BORDER-BOTTOM: #fff 1px solid } UL.npg-resources LI { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BACKGROUND-COLOR: #fff; BORDER-RIGHT-WIDTH: 0px } UL.npg-resources A { PADDING-RIGHT: 5px! important; PADDING-LEFT: 15px! important; = BACKGROUND: url(/common/images/nav_dots2.gif) no-repeat 5px 5px; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } UL.npg-resources A:visited { PADDING-RIGHT: 5px! important; PADDING-LEFT: 15px! important; = BACKGROUND: url(/common/images/nav_dots2.gif) no-repeat 5px 5px; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } UL.npg-resources A:hover { BACKGROUND: url(/common/images/nav_dots1.gif) #0066b3 no-repeat 5px 5px } H1.society-resources { BACKGROUND-COLOR: #0066b3 } UL.society-resources A:hover { BACKGROUND-COLOR: #0066b3 } H1.home { FONT-WEIGHT: bold; FONT-SIZE: 90%; BACKGROUND: none transparent scroll = repeat 0% 0% } #login DIV.passdetails INPUT.button { BACKGROUND-COLOR: #808080 } * HTML #breadcrumb DIV { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 4px; MARGIN: 0px; PADDING-TOP: 4px } #breadcrumb { MARGIN: 0px } #breadcrumb DIV { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 4px; MARGIN: 0px; PADDING-TOP: 4px } #articlenav { DISPLAY: block; MARGIN-BOTTOM: 20px } #articlenav H2 { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; FONT-WEIGHT: bold; FONT-SIZE: = 70%; BACKGROUND: #0066b3; PADDING-BOTTOM: 3px; MARGIN: 0px; = TEXT-TRANSFORM: uppercase; COLOR: #fff; PADDING-TOP: 3px; TEXT-ALIGN: = left } #articlenav DIV.prevnext { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 70%; BACKGROUND: = #f6f6f6; PADDING-BOTTOM: 3px; MARGIN: 0px; PADDING-TOP: 3px; TEXT-ALIGN: = left } #articlenav DIV.prevnext A.prev { PADDING-LEFT: 7px; BACKGROUND: url(/common/images/arrow_black_left.gif) = no-repeat left center } #articlenav DIV.prevnext A.next { PADDING-RIGHT: 7px; BACKGROUND: url(/common/images/arrow_black.gif) = no-repeat right center } #articlenav DIV.prevnext A:link { COLOR: #000; TEXT-DECORATION: none } #articlenav DIV.prevnext A:visited { COLOR: #000; TEXT-DECORATION: none } #articlenav DIV.prevnext A:hover { COLOR: #000; TEXT-DECORATION: underline } #articlenav UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 7px; MARGIN: 1px = 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; BACKGROUND-COLOR: = #f6f6f6; TEXT-ALIGN: left } #articlenav UL LI { BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; BACKGROUND-COLOR: #f6f6f6 } * HTML #articlenav UL A:link { PADDING-RIGHT: 5px! important; PADDING-LEFT: 17px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } * HTML #articlenav UL A:visited { PADDING-RIGHT: 5px! important; PADDING-LEFT: 17px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } * HTML #articlenav UL A:visited { PADDING-RIGHT: 5px! important; PADDING-LEFT: 17px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } #articlenav UL A:link { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 17px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_black.gif) no-repeat 8px 7px; = PADDING-BOTTOM: 3px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 3px; = TEXT-DECORATION: none } #articlenav UL A:visited { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 17px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_black.gif) no-repeat 8px 7px; = PADDING-BOTTOM: 3px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 3px; = TEXT-DECORATION: none } #articlenav UL A:hover { COLOR: #000; TEXT-DECORATION: underline } #articlenav UL A.page { BACKGROUND: url(/common/images/arrow_black_down.gif) no-repeat 4px 8px } #articlenav UL A.page:visited { BACKGROUND: url(/common/images/arrow_black_down.gif) no-repeat 4px 8px } #articlenav UL A.page:hover { COLOR: #000; TEXT-DECORATION: underline } * HTML #articlenav A.toc:link { PADDING-RIGHT: 5px! important; PADDING-LEFT: 8px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } * HTML #articlenav A.toc:visited { PADDING-RIGHT: 5px! important; PADDING-LEFT: 8px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } * HTML #articlenav A.toc:hover { PADDING-RIGHT: 5px! important; PADDING-LEFT: 8px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } #articlenav LI.toc { TEXT-ALIGN: center } #articlenav A.toc:link { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; TEXT-ALIGN: center } #articlenav A.toc:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; TEXT-ALIGN: center } #articlenav A.toc:hover { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; TEXT-ALIGN: center } #articlenav LI.fulltext { BACKGROUND-COLOR: #f6f6f6 } #articlenav DIV.sponsored { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; FONT-SIZE: 70%; BACKGROUND: = url(/ncponc/images/dots.gif) #f6f6f6 repeat-x left top; PADDING-BOTTOM: = 1px; COLOR: #666; PADDING-TOP: 5px; TEXT-DECORATION: none } #extranav DIV.sponsor-space DIV.sponsored { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; FONT-SIZE: 70%; BACKGROUND: = url(/ncponc/images/dots.gif) #f6f6f6 repeat-x left top; PADDING-BOTTOM: = 1px; COLOR: #666; PADDING-TOP: 5px; TEXT-DECORATION: none } #articlenav DIV.sponsor { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; PADDING-BOTTOM: 5px; = PADDING-TOP: 0px; BORDER-BOTTOM: #d3d3d3 1px solid; BACKGROUND-COLOR: = #f6f6f6; TEXT-ALIGN: center } #articlenav IMG.sponsor { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #extranav DIV.sponsor-space DIV.sponsor { BACKGROUND-COLOR: #f6f6f6; TEXT-ALIGN: center } #extranav DIV.sponsor-space DIV.sponsored { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; FONT-SIZE: 70%; BACKGROUND: = url(/ncponc/images/dots.gif) #f6f6f6 repeat-x left top; PADDING-BOTTOM: = 8px; COLOR: #666; PADDING-TOP: 5px; TEXT-DECORATION: none } #extranav DIV.sponsor-space IMG.sponsor { BORDER-TOP-WIDTH: 0px; MARGIN-TOP: 8px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN-BOTTOM: 8px; BORDER-RIGHT-WIDTH: 0px } #extranav DIV.sponsor-space { MARGIN-BOTTOM: 20px; BORDER-BOTTOM: #d3d3d3 1px solid } #articlenav UL A.fulltext:link { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/fulltext.gif) no-repeat 8px 4px; PADDING-BOTTOM: 3px; = COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.fulltext:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/fulltext.gif) no-repeat 8px 4px; PADDING-BOTTOM: 3px; = COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.fulltext:hover { BACKGROUND: url(/common/images/fulltext.gif) #f6f6f6 no-repeat 8px 4px; = COLOR: #000; TEXT-DECORATION: underline } #articlenav LI.fulltext-grey { BACKGROUND-COLOR: #f6f6f6 } * HTML #articlenav UL SPAN.fulltext-grey { PADDING-RIGHT: 5px! important; PADDING-LEFT: 27px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } #articlenav UL SPAN.fulltext-grey { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 27px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/fulltext_grey.gif) no-repeat 8px 3px; = PADDING-BOTTOM: 3px; MARGIN: 0px; COLOR: #999; PADDING-TOP: 3px; = TEXT-DECORATION: none } #articlenav LI.printer { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BACKGROUND-COLOR: #f6f6f6; BORDER-RIGHT-WIDTH: 0px } * HTML #articlenav UL A.printer:link { PADDING-RIGHT: 5px! important; PADDING-LEFT: 25px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } * HTML #articlenav UL A.printer:visited { PADDING-RIGHT: 5px! important; PADDING-LEFT: 25px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } * HTML #articlenav UL A.printer:hover { PADDING-RIGHT: 5px! important; PADDING-LEFT: 25px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } #articlenav UL A.printer:link { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/printer.gif) no-repeat 8px 4px; PADDING-BOTTOM: 3px; = COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.printer:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/printer.gif) no-repeat 8px 4px; PADDING-BOTTOM: 3px; = COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.printer:hover { BACKGROUND: url(/common/images/printer.gif) #f6f6f6 no-repeat 8px 4px; = COLOR: #000; TEXT-DECORATION: underline } #articlenav LI.download-pdf { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BACKGROUND-COLOR: #f6f6f6; BORDER-RIGHT-WIDTH: 0px } #articlenav UL A.download-pdf:link { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/icons/fff/pdf.gif) no-repeat 8px 4px; PADDING-BOTTOM: = 3px; COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.download-pdf:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/icons/fff/pdf.gif) no-repeat 8px 4px; PADDING-BOTTOM: = 3px; COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.download-pdf:hover { BACKGROUND: url(/common/images/icons/fff/pdf.gif) #f6f6f6 no-repeat 8px = 4px; COLOR: #000; TEXT-DECORATION: underline } #articlenav LI.download-pdf-grey { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BACKGROUND-COLOR: #f6f6f6; BORDER-RIGHT-WIDTH: 0px } * HTML #articlenav UL SPAN.download-pdf-grey { PADDING-RIGHT: 5px! important; PADDING-LEFT: 27px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } #articlenav UL SPAN.download-pdf-grey { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 27px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/icons/fff/pdf_grey.gif) no-repeat 8px = 3px; PADDING-BOTTOM: 3px; MARGIN: 0px; COLOR: #999; PADDING-TOP: 3px; = TEXT-DECORATION: none } #articlenav LI.sendtofriend { BORDER-TOP-STYLE: none; BORDER-RIGHT-STYLE: none; BORDER-LEFT-STYLE: = none; BACKGROUND-COLOR: #f6f6f6; BORDER-BOTTOM-STYLE: none } #articlenav UL A.sendtofriend:link { PADDING-RIGHT: 5px! important; PADDING-LEFT: 27px! important; = BACKGROUND: url(/common/images/send_to_a_friend.gif) no-repeat 8px 6px; = PADDING-BOTTOM: 3px! important; COLOR: #000; PADDING-TOP: 3px! important } #articlenav UL A.sendtofriend:visited { PADDING-RIGHT: 5px! important; PADDING-LEFT: 27px! important; = BACKGROUND: url(/common/images/send_to_a_friend.gif) no-repeat 8px 6px; = PADDING-BOTTOM: 3px! important; COLOR: #000; PADDING-TOP: 3px! important } #articlenav UL A.sendtofriend:hover { BACKGROUND: url(/common/images/send_to_a_friend.gif) #f6f6f6 no-repeat = 8px 6px; COLOR: #000; TEXT-DECORATION: underline } #articlenav UL A.cited:link { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/icons/cited.gif) no-repeat 8px 6px; PADDING-BOTTOM: = 3px; COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.cited:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/icons/cited.gif) no-repeat 8px 6px; PADDING-BOTTOM: = 3px; COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.cited:hover { BACKGROUND: url(/common/images/icons/cited.gif) #f6f6f6 no-repeat 8px = 6px; COLOR: #000; TEXT-DECORATION: underline } #articlenav LI.purchase { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BACKGROUND-COLOR: #f6f6f6; BORDER-RIGHT-WIDTH: 0px } #articlenav UL A.purchase:link { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/purchase_article.gif) no-repeat 8px 1px; = PADDING-BOTTOM: 3px; COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.purchase:visited { PADDING-RIGHT: 5px; PADDING-LEFT: 27px; BACKGROUND: = url(/common/images/purchase_article.gif) no-repeat 8px 1px; = PADDING-BOTTOM: 3px; COLOR: #000; PADDING-TOP: 3px } #articlenav UL A.purchase:hover { BACKGROUND: url(/common/images/purchase_article.gif) #f6f6f6 no-repeat = 8px 1px; COLOR: #000; TEXT-DECORATION: underline } #articlenav LI.last { PADDING-BOTTOM: 5px } #articlenav UL.supplementary { PADDING-TOP: 7px } #articlenav UL A.on:link { BACKGROUND: url(/common/images/arrow_white.gif) #0066b3 no-repeat 8px = 8px; COLOR: #fff } #articlenav UL A.on:visited { BACKGROUND: url(/common/images/arrow_white.gif) #0066b3 no-repeat 8px = 8px; COLOR: #fff } #articlenav UL A.on:hover { COLOR: #fff; TEXT-DECORATION: underline } #articlenav-toc { MARGIN-BOTTOM: 20px } #articlenav-toc H2 { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; FONT-WEIGHT: bold; FONT-SIZE: = 70%; PADDING-BOTTOM: 3px; MARGIN: 0px; TEXT-TRANSFORM: uppercase; COLOR: = #fff; PADDING-TOP: 3px; TEXT-ALIGN: left } #articlenav-toc UL LI A.prev:link { BACKGROUND: url(/common/images/arrow_black_left.gif) no-repeat 8px 7px } #articlenav-toc UL LI A.prev:visited { BACKGROUND: url(/common/images/arrow_black_left.gif) no-repeat 8px 7px } #articlenav-toc UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 7px; MARGIN: 1px = 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; BACKGROUND-COLOR: = #f6f6f6; TEXT-ALIGN: left } #articlenav-toc UL LI { BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; BACKGROUND-COLOR: #f6f6f6 } * HTML #articlenav-toc UL A { PADDING-RIGHT: 5px! important; PADDING-LEFT: 17px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } * HTML #articlenav-toc UL A:visited { PADDING-RIGHT: 5px! important; PADDING-LEFT: 17px! important; = PADDING-BOTTOM: 3px! important; PADDING-TOP: 3px! important } #articlenav-toc UL A:link { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 17px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_black.gif) no-repeat 8px 7px; = PADDING-BOTTOM: 3px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 3px; = TEXT-DECORATION: none } #articlenav-toc UL A:visited { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 17px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_black.gif) no-repeat 8px 7px; = PADDING-BOTTOM: 3px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 3px; = TEXT-DECORATION: none } #articlenav-toc UL A:hover { COLOR: #000; TEXT-DECORATION: underline } #articlenav-toc UL A.on { BACKGROUND: url(/common/images/arrow_white.gif) #0066b3 no-repeat 8px = 8px; COLOR: #fff } #articlenav UL A.on:visited { BACKGROUND: url(/common/images/arrow_white.gif) #0066b3 no-repeat 8px = 8px; COLOR: #fff } #articlenav-toc UL A.on:hover { COLOR: #fff; TEXT-DECORATION: underline } A.listlinks { DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 90%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat left center } A.listlinks:visited { BACKGROUND: url(/common/images/arrow_purple_right.gif) no-repeat left = center } A.listlinks:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat left center } A.listlinks-small:link { DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat left center } A.listlinks-small:visited { DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue.gif) no-repeat left center } A.listlinks-small:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat left center } A.listlinksd { DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 90%; BACKGROUND: = url(/common/images/arrow_blue_down.gif) no-repeat left center } A.listlinksd:visited { BACKGROUND: url(/common/images/arrow_purple_down.gif) no-repeat left = center } A.listlinksd:hover { BACKGROUND: url(/common/images/arrow_red_down.gif) no-repeat left = center } A.listlinksd-small:link { DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue_down.gif) no-repeat left center } A.listlinksd-small:visited { DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue_down.gif) no-repeat left center } A.listlinksd-small:hover { BACKGROUND: url(/common/images/arrow_red_down.gif) no-repeat left = center } #breadcrumb SPAN.divider { FONT-SIZE: 70%; COLOR: #999 } DIV.ad-horiz { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left top; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-horiz-rect { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 70%; = BORDER-BOTTOM-WIDTH: 0px; MARGIN-BOTTOM: 20px; COLOR: #ccc; PADDING-TOP: = 10px; TEXT-ALIGN: center; BORDER-RIGHT-WIDTH: 0px } DIV.ad-horiz-rect IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 300px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 250px; BORDER-RIGHT-WIDTH: 0px } H1.page-header { FONT-SIZE: 120%; BACKGROUND: url(/clinicalpractice/images/dotted.gif) = repeat-x left bottom; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 1px; = TEXT-TRANSFORM: uppercase; FONT-FAMILY: arial, helvetica, sans-serif } SPAN.page-header-spacer { FONT-SIZE: 120%; PADDING-BOTTOM: 0px; FONT-FAMILY: arial, helvetica, = sans-serif } DIV.reg-rec { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = MARGIN-BOTTOM: 20px; PADDING-BOTTOM: 0px; PADDING-TOP: 10px; = BORDER-BOTTOM: #d3d3d3 1px solid } DIV.reg-rec P { MARGIN: 0px } DIV.reg-rec A.register { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 20px; BACKGROUND: = url(/common/images/extranav_register.gif) no-repeat 0px 0.3em; = MARGIN-BOTTOM: 0.7em; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } DIV.reg-rec A.recommend { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 20px; BACKGROUND: = url(/common/images/extranav_recommend.gif) no-repeat left top; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } DIV.reg-rec A:link { FONT-SIZE: 70%; MARGIN-BOTTOM: 10px; COLOR: #000; TEXT-DECORATION: none } DIV.reg-rec A:visited { FONT-SIZE: 70%; MARGIN-BOTTOM: 10px; COLOR: #000; TEXT-DECORATION: none } DIV.reg-rec A:hover { COLOR: #000; TEXT-DECORATION: underline } #home .boxrow H2 { FONT-WEIGHT: bold; FONT-SIZE: 80%; MARGIN: 0px } #home DIV.featured-articles A { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; PADDING-BOTTOM: 15px } #home DIV.featured-articles DIV.supplementary { BORDER-TOP: #eaeaea 1px solid; MARGIN-BOTTOM: 20px; PADDING-TOP: 5px } #home DIV.featured-articles DIV.supplementary A { DISPLAY: inline; FONT-WEIGHT: normal; FONT-SIZE: 70%; COLOR: #c03 } #home DIV.featured-articles DIV.supplementary A:visited { DISPLAY: inline; FONT-WEIGHT: normal; FONT-SIZE: 70%; COLOR: #c03 } #home DIV.featured-articles DIV.supplementary A:hover { DISPLAY: inline; FONT-WEIGHT: normal; FONT-SIZE: 70%; COLOR: #c03 } #home DIV.journal-details { FONT-SIZE: 90%; BACKGROUND: url(/ncponc/images/dots.gif) repeat-x left = top; FLOAT: none; WIDTH: 100%; PADDING-TOP: 1em } #home DIV.journal-details IMG.journal-cover { BORDER-RIGHT: #cfcfcf 1px solid; BORDER-TOP: #cfcfcf 1px solid; FLOAT: = left; MARGIN: 0px 1em 1em 0px; BORDER-LEFT: #cfcfcf 1px solid; = BORDER-BOTTOM: #cfcfcf 1px solid } #home DIV.journal-details P { MARGIN: 0px 0px 1em } #home DIV.journal-details P SPAN.volume { FONT-WEIGHT: bold } #home DIV.journal-details P SPAN.impact { FONT-WEIGHT: bold } #home .middots { BACKGROUND: url(/clinicalpractice/images/dottedv.gif) repeat-y center = top } #home .boxrow { BACKGROUND: url(/clinicalpractice/images/dotted.gif) repeat-x center = top; MARGIN-BOTTOM: 2%; PADDING-TOP: 2% } #home .boxrow .l { FLOAT: left; WIDTH: 48% } #home .boxrow .r { FLOAT: right; WIDTH: 48% } #home .boxrow P { FONT-SIZE: 90% } #home IMG.featured_article { FLOAT: left; MARGIN: 0px 10px 10px 0px; WIDTH: 95px } #home #extranav A.topten { PADDING-RIGHT: 0pt; BORDER-TOP: medium none; PADDING-LEFT: 22px; = FONT-SIZE: 70%; BACKGROUND: url(/aj/images/icon_topten.gif) no-repeat = left bottom; PADDING-BOTTOM: 2px; PADDING-TOP: 7px } #extranav A.topten:link { PADDING-RIGHT: 0pt; BORDER-TOP: medium none; PADDING-LEFT: 22px; = FONT-SIZE: 70%; BACKGROUND: url(/aj/images/icon_topten.gif) no-repeat = left bottom; PADDING-BOTTOM: 2px; PADDING-TOP: 7px } #extranav A.topten:visited { BACKGROUND: url(/common/images/arrow_purple_right.gif) no-repeat 0px = 1.2em } #home #extranav A.topten:hover { TEXT-DECORATION: underline } DIV.backtotop { BACKGROUND: url(/ncponc/images/dots.gif) repeat-x left top; MARGIN: 0px = 0px 1em; PADDING-TOP: 3px; TEXT-ALIGN: right } #article DIV.backtotop { BACKGROUND: url(/ncponc/images/dots.gif) repeat-x left top; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 3px; TEXT-ALIGN: right } #toc DIV.backtotop { BACKGROUND: url(/ncponc/images/dots.gif) repeat-x left top; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 3px; TEXT-ALIGN: right } A.backtotop2 { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_black_up.gif) no-repeat 0px 0.6em; = PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px; TEXT-DECORATION: = none } A.backtotop2:visited { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_black_up.gif) no-repeat 0px 0.6em; = PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px; TEXT-DECORATION: = none } A.backtotop2:hover { TEXT-DECORATION: underline } #article #content DIV { PADDING-BOTTOM: 1.5em } #article #content H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 105%; BACKGROUND: url(/ncponc/images/dots.gif) repeat-x left bottom; = PADDING-BOTTOM: 3px; MARGIN: 0px; TEXT-TRANSFORM: uppercase; COLOR: = #000; PADDING-TOP: 3px; FONT-FAMILY: arial, helvetica, sans-serif } #article #content H4.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 1em 0px 0px; TEXT-TRANSFORM: = uppercase } #article #content #original-article H5 { MARGIN-TOP: 0.3em; DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 70% } #article #content #original-article P { MARGIN-TOP: 0.3em; DISPLAY: inline; FONT-SIZE: 70% } IMG.ebm_cme_small { FLOAT: left; MARGIN: 0.1em 0.5em 0.5em 0px; WIDTH: 29px; HEIGHT: 26px } #article #content #cite P { MARGIN-TOP: 0.3em; MARGIN-BOTTOM: 0px } #article #content #cite IMG.doihelp { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: middle; WIDTH: 13px; HEIGHT: 13px; = BORDER-RIGHT-WIDTH: 0px } #article #content #cite IMG.ebm_cme { FLOAT: left; MARGIN: 0.3em 0.5em 0px 0px; WIDTH: 43px; HEIGHT: 43px } #article #content H5.norm { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article #content H5.italic-norm { DISPLAY: block; FONT-WEIGHT: normal; FONT-SIZE: 90%; MARGIN-BOTTOM: = 0px; FONT-STYLE: italic } #article #content DIV P.norm { FONT-SIZE: 90%; MARGIN: 1em 0px 0px } #article #content DIV BLOCKQUOTE.pullquote { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #999 = 1px solid; DISPLAY: inline; PADDING-LEFT: 0.5em; FONT-SIZE: 90%; FLOAT: = left; PADDING-BOTTOM: 0.5em; MARGIN: 1.26em 1.26em 1.26em 0px; = BORDER-LEFT: #999 1px solid; WIDTH: 35%; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #999 1px solid; TEXT-ALIGN: left } #article #content DIV BLOCKQUOTE.pullquote P { MARGIN: 0px } #article #content DIV BLOCKQUOTE.pullquote IMG.top { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MARGIN: 0px 0.4em 0px 0px; WIDTH: 12px; HEIGHT: 10px; = BORDER-RIGHT-WIDTH: 0px } #article #content DIV BLOCKQUOTE.pullquote IMG.base { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MARGIN: 0px 0px 0px 0.4em; WIDTH: 12px; HEIGHT: 10px; = BORDER-RIGHT-WIDTH: 0px } #article #content P.follows-h4 { FONT-SIZE: 90%; MARGIN: 0px } #article #content P.follows-h5 { DISPLAY: inline; FONT-SIZE: 90% } #article #content OL.norm { FONT-SIZE: 90% } #article #content UL.norm { FONT-SIZE: 90% } #article #content DL.norm { FONT-SIZE: 90% } #article #content #subjectcategories { FONT-SIZE: 70% } #article #content #cite { FONT-SIZE: 70% } #article #content #errorcor { FONT-SIZE: 70% } #article #content #errorcor A { COLOR: #c03 } #article #content #atl { FONT-WEIGHT: normal; FONT-SIZE: 130% } #article #content #artnote { FONT-SIZE: 90% } #article #content #aug { FONT-WEIGHT: bold; FONT-SIZE: 90% } #article #content #aug A { FONT-WEIGHT: normal; FONT-SIZE: 80% } #article #content P.caff { FONT-SIZE: 70% } #article #content P.caff SPAN { FONT-WEIGHT: bold } #article #content P.extnote { MARGIN-TOP: 0px; FONT-SIZE: 80%; FONT-STYLE: italic } #article #content P.aunote { FONT-SIZE: 70% } #article #content P.tlnote { FONT-SIZE: 70% } #article #content P.prdates { FONT-SIZE: 70% } #article #content .glossary_term { TEXT-TRANSFORM: uppercase } #article #content P.footnote { FONT-SIZE: 90% } #article #content P.endnote { FONT-SIZE: 90% } #article #content P.closenote { FONT-SIZE: 90% } #article #content P.author-base { FONT-WEIGHT: normal; FONT-SIZE: 90%; FONT-STYLE: italic } #article #content #contact-subject { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #article #content #contact-subject P { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue2_right.gif) no-repeat 0px 0.4em; = PADDING-BOTTOM: 0.5em; MARGIN: 0px; PADDING-TOP: 0px } #article #affiliations-notes OL { PADDING-LEFT: 0px; LIST-STYLE-POSITION: inside; FONT-SIZE: 70%; = MARGIN-LEFT: 0px } #article #content #erratum-text A.back { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/arrow_blue2_right.gif) no-repeat 0px 0.4em; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article #content #erratum-text A.back:visited { BACKGROUND: url(/common/images/arrow_purple_right.gif) no-repeat 0px = 0.4em } #article #content #erratum-text A.back:hover { BACKGROUND: url(/common/images/arrow_red_right.gif) no-repeat 0px = 0.4em; TEXT-DECORATION: underline } #article #content #erratum-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left top; PADDING-BOTTOM: 0px; = MARGIN: 1em 0px 0px; PADDING-TOP: 0.5em } #logged-in-inpage { BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 5px; PADDING-LEFT: 5px; = FLOAT: right; PADDING-BOTTOM: 5px; BORDER-LEFT: black 1px solid; WIDTH: = 16em! important; PADDING-TOP: 10px; HEIGHT: 4em! important; = BACKGROUND-COLOR: #eaeaea } #logged-in-inpage P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 80%; PADDING-BOTTOM: = 0px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 0px } #logged-in-inpage A { FONT-SIZE: 80% } #logged-in-inpage .username { FONT-WEIGHT: bold; MARGIN-LEFT: 26px; VERTICAL-ALIGN: middle; = LINE-HEIGHT: 20px } #login-inpage { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FLOAT: left; PADDING-BOTTOM: = 5px; MARGIN: 0px; WIDTH: 19em! important; COLOR: #000; PADDING-TOP: 5px } #login-inpage A { FONT-SIZE: 70% } #login-inpage DIV.userpassbox { FLOAT: left; WIDTH: 8em } .passdetails { FLOAT: left } #login-inpage INPUT.text { FONT-SIZE: 80%; MARGIN: 0px; WIDTH: 9em; COLOR: #000 } #login-inpage LABEL { FONT-SIZE: 70% } #login-inpage INPUT.button { MARGIN-TOP: 5px } #login-inpage #savepass { MARGIN-BOTTOM: -2px } #login-inpage DIV.error { PADDING-LEFT: 20px; BACKGROUND: url(/common/images/login_error.gif) = no-repeat 0px 4px; FLOAT: left; MARGIN-BOTTOM: 5px; COLOR: #c30 } #login-inpage DIV.error SPAN { FONT-WEIGHT: bold } #article #content #articlebody .takehome { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; BORDER-LEFT: #999 1px = solid; PADDING-TOP: 5px; BORDER-BOTTOM: #999 1px solid } #article #content #articlebody .takehome UL.thome { LIST-STYLE-POSITION: inside; FONT-SIZE: 90%; MARGIN: 0px; PADDING-TOP: = 10px } #article #content #articlebody .review { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; BORDER-LEFT: #999 1px = solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px solid } #article #content #articlebody .disclaimer { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; BORDER-LEFT: #999 1px = solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px solid } #article #content #articlebody .review { LINE-HEIGHT: 130% } #article #content #articlebody .review LI { PADDING-BOTTOM: 15px; LINE-HEIGHT: 130% } #article #content #articlebody .review H4.abs { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; = TEXT-TRANSFORM: uppercase } #article #content #articlebody .disclaimer H4.abs { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; = TEXT-TRANSFORM: uppercase } #article #content #articlebody .review P.norm { MARGIN: 0px } #article #content #articlebody .disclaimer P.norm { MARGIN: 0px } #article #content #articlebody .review P.follows-h4 { DISPLAY: block; FONT-SIZE: 90% } #article #content #articlebody .disclaimer P.follows-h4 { DISPLAY: block; FONT-SIZE: 90% } #article #content #practice-point H4 { DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; = TEXT-TRANSFORM: uppercase } #article #content #practice-point P { FONT-SIZE: 90%; MARGIN: 0px } #article #content #articlebody P.lead { FONT-SIZE: 90% } #article #content #articlebody P.clinical-context { FONT-WEIGHT: bold } #article #content #articlebody H4.abs { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article #content #articlebody P.follows-h4 { DISPLAY: block; FONT-SIZE: 90% } #article #content #articlebody DIV { MARGIN-TOP: 1em; PADDING-BOTTOM: 0px } #article #content DIV#practice-point { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; MARGIN: 1em 0px; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px = solid } #article #content DIV.keyw-abbr H5.keywords { DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 90% } #article #content DIV.keyw-abbr P.keywords { DISPLAY: inline; FONT-SIZE: 90% } #article #content #References OL LI { FONT-SIZE: 90% } #article #content #more-like-this { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: 25px 0px; = BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #ccc 1px = solid } #article #content #more-like-this H3 { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; PADDING-BOTTOM: 3px; MARGIN: 0px; PADDING-TOP: 3px; = BACKGROUND-COLOR: #f6f6f6 } #article #content #more-like-this DIV.wrapper { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 0px } #article #content #more-like-this P.explain { FONT-SIZE: 80%; MARGIN: 10px } #article #content #more-like-this A.article { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 80%; MARGIN: 0px; COLOR: = #666 } #article #content #more-like-this A.article:hover { COLOR: #c03 } #article #content #more-like-this P.journal { FONT-SIZE: 80%; MARGIN: 0px; FONT-STYLE: italic } #article #content #more-like-this P.journal SPAN { FONT-STYLE: normal } #article #content #more-like-this H4.area { PADDING-LEFT: 0px; FONT-SIZE: 80%; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #000; BACKGROUND-COLOR: transparent } #article #content #more-like-this A.allmatches:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 80%; = BACKGROUND: url(/common/images/icons/c03/arrow_s.gif) no-repeat left = center; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #c03; PADDING-TOP: 0px } #article #content #more-like-this A.allmatches:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 80%; = BACKGROUND: url(/common/images/icons/c03/arrow_s.gif) no-repeat left = center; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #c03; PADDING-TOP: 0px } #article #content #more-like-this A.allmatches:hover { BACKGROUND: url(/common/images/icons/c03/arrow_s.gif) no-repeat left = center } * HTML #article-related #breadcrumb DIV { PADDING-LEFT: 1% } #article-related #breadcrumb DIV { PADDING-LEFT: 1% } #article-related #content H2.note { FONT-WEIGHT: normal; FONT-SIZE: 80%; MARGIN: 0px } #article-related P.atl { FONT-WEIGHT: bold; FONT-SIZE: 80%; MARGIN: 0px } #article-related P.doi { FONT-SIZE: 80%; MARGIN: 0px } #article-related UL.more-articles { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article-related UL.more-articles LI { MARGIN: 10px 0px } #article-related UL.more-articles A { FONT-SIZE: 90% } #article-related UL.more-articles CITE { FONT-SIZE: 80%; FONT-STYLE: normal } #article-related .container-more { BORDER-BOTTOM-WIDTH: 0px! important } #info #content H2.page { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; BACKGROUND: url(/clinicalpractice/images/dotted.gif) repeat-x 0px = 0px; PADDING-BOTTOM: 0px; MARGIN: 1em 0px; COLOR: #000; PADDING-TOP: = 0.8em } #info #content P { FONT-SIZE: 90% } #info #content DIV.container { MARGIN: 0px 0px 20px } #info #content DIV.container-cols { MARGIN: 0px 0px 1em } #info #content DIV.container P { FONT-SIZE: 90% } #info #content H2.block { PADDING-RIGHT: 0.3em; PADDING-LEFT: 0.3em; FONT-WEIGHT: bold; = FONT-SIZE: 80%; PADDING-BOTTOM: 0.3em; MARGIN: 0px; TEXT-TRANSFORM: = uppercase; COLOR: #fff; PADDING-TOP: 0.3em } #info #content H2.block A { COLOR: #fff; TEXT-DECORATION: none } #info #content H2.block A:visited { COLOR: #fff; TEXT-DECORATION: none } #info #content H2.block A:hover { COLOR: #fff; TEXT-DECORATION: underline } #info #content H2.topten { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 105%; BACKGROUND: url(/ncponc/images/dots.gif) repeat-x left bottom; = PADDING-BOTTOM: 3px; MARGIN: 0px; TEXT-TRANSFORM: uppercase; COLOR: = #000; PADDING-TOP: 3px; FONT-FAMILY: arial, helvetica, sans-serif } #info #content H2.editor { FONT-SIZE: 90%; COLOR: #000 } #info #content H3 { DISPLAY: inline; FONT-SIZE: 90% } #info #content P.follows-h3 { MARGIN-TOP: 0px; PADDING-TOP: 0px } #info #content DIV.left-col P { FONT-SIZE: 80%; MARGIN: 1em 0px } #info #content DIV.right-col P { FONT-SIZE: 80%; MARGIN: 1em 0px } #info #content DIV.left-col { CLEAR: left; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; = PADDING-BOTTOM: 0px; WIDTH: 48%; PADDING-TOP: 0px } #info #content DIV.right-col { CLEAR: right; FLOAT: right; MARGIN: 0px; WIDTH: 48% } #info DIV.picttext IMG { MARGIN: 0px; BORDER-BOTTOM: #000 1px solid } #info DIV.picttext { BORDER-RIGHT: #000 1px solid; BORDER-TOP: #000 1px solid; FONT-SIZE: = 80%; BACKGROUND: #f6f6f6; FLOAT: left; MARGIN: 0.3em 1em 1em 0px; = BORDER-LEFT: #000 1px solid; WIDTH: 140px; BORDER-BOTTOM: #000 1px solid } #info DIV.picttext P { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: = 0px; PADDING-TOP: 5px } #info DIV.picttext P SPAN { FONT-WEIGHT: bold } #info #content OL { FONT-WEIGHT: bold } #info #content OL LI { LIST-STYLE-POSITION: outside } #info #content OL LI P { MARGIN: 0px } #info #content OL LI P.article-title { DISPLAY: inline; FONT-WEIGHT: bold } #info #content OL LI P.author { FONT-WEIGHT: normal } #info #content OL LI P.issue { FONT-WEIGHT: normal; FONT-SIZE: 80%; MARGIN-BOTTOM: 1em } #info DIV.pict { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0.3em 1em 1em 0px; PADDING-TOP: 0px } #info DIV.pda-login { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px = solid; MARGIN-TOP: 2em; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-COLOR: #f5f5f5 } #info DIV.pda-login H5.norm { MARGIN-TOP: 0px; FONT-SIZE: 90%; MARGIN-BOTTOM: 1em } #info DIV.pda-login SPAN { FONT-WEIGHT: bold } #info DIV.pda-login OL { FONT-WEIGHT: bold; MARGIN: 1em 0px 0px } #info DIV.pda-login LI SPAN.first { FONT-WEIGHT: bold; FONT-SIZE: 90% } #info DIV.pda-login LI SPAN.second { DISPLAY: block; FONT-WEIGHT: normal; FONT-SIZE: 90% } #info DIV.pda-login LI { MARGIN: 0px 0px 0.2em } #info DIV.pda-login FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: normal; FONT-SIZE: = 70%; PADDING-BOTTOM: 0px; MARGIN: 0.2em 0px 0px; PADDING-TOP: 0px } #info DIV.pda-login FORM INPUT { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0.2em 0px 0px } #info DIV.pda-login FORM INPUT.button { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } #info DIV.pda-login H6 { DISPLAY: block; MARGIN-BOTTOM: 1em } #info A.pda-button:link { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: #000 1px = solid; PADDING-LEFT: 3px; FONT-WEIGHT: bold; PADDING-BOTTOM: 3px; = BORDER-LEFT: #000 1px solid; COLOR: #fff; PADDING-TOP: 3px; = BORDER-BOTTOM: #000 1px solid; BACKGROUND-COLOR: #0066b3; = TEXT-DECORATION: none } #info A.pda-button A:hover { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: #000 1px = solid; PADDING-LEFT: 3px; FONT-WEIGHT: bold; PADDING-BOTTOM: 3px; = BORDER-LEFT: #000 1px solid; COLOR: #fff; PADDING-TOP: 3px; = BORDER-BOTTOM: #000 1px solid; BACKGROUND-COLOR: #0066b3; = TEXT-DECORATION: none } #info A.pda-button A:visited { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: #000 1px = solid; PADDING-LEFT: 3px; FONT-WEIGHT: bold; PADDING-BOTTOM: 3px; = BORDER-LEFT: #000 1px solid; COLOR: #fff; PADDING-TOP: 3px; = BORDER-BOTTOM: #000 1px solid; BACKGROUND-COLOR: #0066b3; = TEXT-DECORATION: none } #info #content H2.norm { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 105%; BACKGROUND: = url(/ncpcardio/images/dots.gif) repeat-x left bottom; = BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 3px; MARGIN: 0px; = TEXT-TRANSFORM: uppercase; COLOR: #000; PADDING-TOP: 3px; FONT-FAMILY: = arial, helvetica, sans-serif; BORDER-RIGHT-WIDTH: 0px } #info #content DIV.ebm { MARGIN: 1em 0px } #info #content DIV.ebm P { MARGIN: 0px } #info #content DIV.ebm IMG.ebm_cme { FLOAT: left; MARGIN: 0.3em 0.5em 0px 0px; WIDTH: 43px; HEIGHT: 43px } #info #content DIV.instructions UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #info #content DIV.instructions UL.sub { MARGIN-LEFT: 10px } #info #content DIV.instructions UL.sub LI { MARGIN: 0px 0px 10px } #info #content DIV.instructions UL LI.box { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #fafafa; = MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 5px; PADDING-TOP: 5px } #info #content DIV.instructions UL LI H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; FONT-SIZE: 100%; BACKGROUND: = url(/clinicalpractice/images/arrow_black.gif) no-repeat 0em 0.2em; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 0px } #info #content DIV.author-form FORM { FLOAT: left; WIDTH: 49% } #info #content DIV.author-form FIELDSET { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } #info #content DIV.author-form LEGEND { DISPLAY: none } #info #content DIV.author-form FIELDSET UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #info #content DIV.author-form FIELDSET UL LI { MARGIN: 0px 0px 10px } #info #content DIV.author-form DIV.links { FLOAT: left; WIDTH: 49% } #info #content DIV.author-form DIV.links P { PADDING-LEFT: 15px; BACKGROUND: = url(/clinicalpractice/images/icon_doi.gif) no-repeat 0em 0.2em } #archive #content DIV.container { MARGIN: 0px 0px 20px } #results #content DIV.container { MARGIN: 0px 0px 20px } #archive #content H3 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 105%; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left bottom; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 3px; MARGIN: 0px; TEXT-TRANSFORM: uppercase; COLOR: = #000; PADDING-TOP: 3px; FONT-FAMILY: arial, helvetica, sans-serif; = BORDER-RIGHT-WIDTH: 0px } #archive SPAN.jump { FONT-WEIGHT: bold } #archive TABLE.archive { FONT-SIZE: 90%; WIDTH: 100%; BORDER-COLLAPSE: collapse; TEXT-ALIGN: = center } #archive TABLE.archive TR.middle TD.inactive { BORDER-RIGHT: #ccc 1px solid; BACKGROUND: #fff; BORDER-LEFT: #ccc 1px = solid; COLOR: #ccc } #archive TABLE.archive TR.base TD.inactive { BORDER-TOP-WIDTH: 0px; BORDER-RIGHT: #ccc 1px solid; FONT-SIZE: 80%; = BACKGROUND: #fff; BORDER-LEFT: #ccc 1px solid; COLOR: #ccc; = BORDER-BOTTOM: #ccc 1px solid } #archive TABLE.archive TH.inactive { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BACKGROUND: = #fff; BORDER-LEFT: #ccc 1px solid; COLOR: #ccc } #archive TABLE.archive TH { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0.4em; BORDER-TOP: #999 = 1px solid; PADDING-LEFT: 0.4em; BACKGROUND: #f6f6f6; PADDING-BOTTOM: = 0.4em; BORDER-LEFT: #999 1px solid; PADDING-TOP: 0.4em } #archive TABLE.archive TH.left-top { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 1px solid; BACKGROUND: = #f6f6f6; BORDER-LEFT: #999 1px solid; TEXT-ALIGN: left } #archive TABLE.archive TH.left { BORDER-TOP-WIDTH: 0px; BORDER-RIGHT: #999 1px solid; FONT-WEIGHT: bold; = BACKGROUND: #f6f6f6; BORDER-LEFT: #999 1px solid; TEXT-ALIGN: left } #archive TABLE.archive TH.left-base { BORDER-TOP-WIDTH: 0px; BORDER-RIGHT: #999 1px solid; FONT-WEIGHT: = normal; FONT-SIZE: 80%; BACKGROUND: #f6f6f6; BORDER-LEFT: #999 1px = solid; BORDER-BOTTOM: #999 1px solid; TEXT-ALIGN: left } #archive TABLE.archive TR.middle TD { BORDER-TOP-WIDTH: 0px; BORDER-RIGHT: #999 1px solid; = BORDER-BOTTOM-WIDTH: 0px; BORDER-LEFT: #999 1px solid } #archive TABLE.archive TR.base TD { BORDER-TOP-WIDTH: 0px; BORDER-RIGHT: #999 1px solid; FONT-SIZE: 80%; = BORDER-LEFT: #999 1px solid; BORDER-BOTTOM: #999 1px solid } #archive TABLE.archive CAPTION { FONT-WEIGHT: bold; PADDING-BOTTOM: 1em; WIDTH: auto; TEXT-ALIGN: left; = caption-side: top } #archive #content H4.inline { DISPLAY: inline; FONT-SIZE: 90%; MARGIN: 0px } #archive #content P.follows-h4 { DISPLAY: inline; FONT-SIZE: 90%; MARGIN: 0px } #archive #content P { FONT-SIZE: 90%; MARGIN: 0.5em 0px } #results #content P { FONT-SIZE: 90%; MARGIN: 0.5em 0px } #archive #content H3 { MARGIN-BOTTOM: 0.5em } #content DIV.container P.left-col { FLOAT: left; WIDTH: 48% } #content DIV.container P.right-col { FLOAT: right; WIDTH: 48% } #results #content DIV.container #search-results { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left top; PADDING-BOTTOM: 0px; = MARGIN: 0px 0px 1em; PADDING-TOP: 0.5em } #results #content DIV.container #search-results-article { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 1em; PADDING-TOP: 0.5em } #results #content DIV.container #search-results-alpha { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left bottom; PADDING-BOTTOM: 1em; = MARGIN: 0px 0px 1em; PADDING-TOP: 0px } #results #content DIV.container P.one-page { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left bottom; PADDING-BOTTOM: 1em; = MARGIN: 0px 0px 1em; PADDING-TOP: 0px } #results #content DIV.container DIV.last { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left bottom; PADDING-BOTTOM: 1em; = MARGIN: 0px 0px 1em; PADDING-TOP: 0px } #results #content DIV.container .author#search-results { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 1em; = PADDING-TOP: 0px } #results #content DIV.container #search-results P.description { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #results #content DIV.container DIV#search-results P.num-results { FONT-SIZE: 70% } #results #content .highlight { COLOR: #c33 } #results #content H3.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px 0px 15px } #results #content H4.highlight { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 1em 0px 0px } #results #content P.articlename { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #results #content DIV.container #select-subject { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #results #content DIV.container DIV.select-subject { PADDING-RIGHT: 10px; MARGIN-TOP: 1px; PADDING-LEFT: 10px; BACKGROUND: = #f6f6f6; PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #results #content DIV.container P.info { FONT-SIZE: 70% } #results #content DIV.container P.num-results A.select { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/arrow_blue2_down.gif) no-repeat left center; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #results #content DIV.container P.num-results A.select:visited { BACKGROUND: url(/common/images/arrow_purple_down.gif) no-repeat left = center } #results #content DIV.container P.num-results A.select:hover { BACKGROUND: url(/common/images/arrow_red_down.gif) no-repeat left = center } #results #content DIV.container #search-results DIV.results-nav { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 80%; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left bottom; PADDING-BOTTOM: 0px; = MARGIN: 1em 0px; PADDING-TOP: 0.5em } #results #content DIV.container #search-results-article DIV.results-nav = { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 80%; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left bottom; PADDING-BOTTOM: 0px; = MARGIN: 1em 0px; PADDING-TOP: 0.5em } #results #content DIV.container #search-results-article H2 { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-WEIGHT: = bold; FONT-SIZE: 90%; BACKGROUND: url(/ncponc/images/dots.gif) repeat-x = left bottom; PADDING-BOTTOM: 0.25em; MARGIN: 1em 0px; PADDING-TOP: 0px } #results #content DIV.container P.prevnext { DISPLAY: inline; FLOAT: right } #results #content DIV.container P.prevnext A.prev { PADDING-LEFT: 7px; BACKGROUND: url(/common/images/arrow_black_left.gif) = no-repeat left center } #results #content DIV.container P.prevnext A.next { PADDING-RIGHT: 7px; BACKGROUND: url(/common/images/arrow_black.gif) = no-repeat right center } #results #content DIV.container P.prevnext A { COLOR: #000; TEXT-DECORATION: none } #results #content DIV.container P.prevnext A:visited { COLOR: #000; TEXT-DECORATION: none } #results #content DIV.container P.prevnext A:hover { COLOR: #000; TEXT-DECORATION: underline } #results #content DIV.container DIV.listing { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 1em; MARGIN: = 0px; PADDING-TOP: 0px } #archive #content DIV.container DIV.listing { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 1em; MARGIN: = 0px; PADDING-TOP: 0px } #results #content DIV.container DIV.listing-alpha { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #results #content DIV.container P.page { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left top; PADDING-BOTTOM: 0.5em; = MARGIN: 0px; PADDING-TOP: 0.5em } #results #content DIV.container DIV#search-results P.num-results SPAN { FONT-WEIGHT: bold } #results #content DIV.backtotop { MARGIN: 0px 0px 1em } #archive #content DIV.backtotop { MARGIN: 0px 0px 1em } #results #content UL.left-col { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0px; WIDTH: 48%; PADDING-TOP: 0px; = LIST-STYLE-TYPE: none; TEXT-ALIGN: left } #results #content UL.right-col { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; FLOAT: right; = PADDING-BOTTOM: 0px; MARGIN: 0px; WIDTH: 48%; PADDING-TOP: 0px; = LIST-STYLE-TYPE: none; TEXT-ALIGN: left } #content A.jump-out { PADDING-LEFT: 8px; BACKGROUND: = url(/common/images/arrow_blue2_right.gif) no-repeat 0px 0.5em } #toc UL.weblinks LI { PADDING-LEFT: 8px; BACKGROUND: = url(/common/images/arrow_blue2_right.gif) no-repeat 0px 0.5em } #content A.jump-out:visited { BACKGROUND: url(/common/images/arrow_purple_right.gif) no-repeat 0px = 0.5em } #content A.jump-out:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat 0px 0.5em } #content #browse-letter { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #results #content #browse-letter { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #content #browse-letter H4 { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #content #search-author { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #results #content #search-author { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #archive #content #search-author H4 { DISPLAY: inline; FONT-SIZE: 90%; MARGIN: 0px } #results #content H2 { DISPLAY: inline; FONT-SIZE: 90%; MARGIN: 0px } #results #content #search-author H4 { DISPLAY: inline; FONT-SIZE: 90%; MARGIN: 0px } #archive #content #search-author FORM { DISPLAY: inline; FONT-SIZE: 90%; MARGIN: 0px } #results #content #search-author FORM { DISPLAY: inline; FONT-SIZE: 90%; MARGIN: 0px } #archive #content #search-author DIV { DISPLAY: inline; MARGIN: 0px } #results #content #search-author DIV { DISPLAY: inline; MARGIN: 0px } #archive #content #search-author .search-text { FONT-SIZE: 80%; COLOR: #000 } #results #content #search-author .search-text { FONT-SIZE: 80%; COLOR: #000 } #toc #content DIV.journal-details { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 10px; MARGIN: 0px 0px 1em; PADDING-TOP: 10px } #toc #content DIV.journal-details P { MARGIN: 0px } #toc #content A.jump { PADDING-LEFT: 15px; FONT-SIZE: 90%; BACKGROUND: = url(/common/images/arrow_blue2_down.gif) no-repeat 0px 0.5em } #toc #content A.jump:visited { BACKGROUND: url(/common/images/arrow_purple_down.gif) no-repeat 0px = 0.5em } #toc #content A.jump:hover { BACKGROUND: url(/common/images/arrow_red_down.gif) no-repeat 0px 0.5em } #toc #content A.jump-out { PADDING-LEFT: 8px; FONT-SIZE: 80%; BACKGROUND: = url(/common/images/arrow_blue2_right.gif) no-repeat 0px 0.5em } #toc #content A.jump-out:visited { BACKGROUND: url(/common/images/arrow_purple_right.gif) no-repeat 0px = 0.5em } #toc #content A.jump-out:hover { BACKGROUND: url(/common/images/arrow_red.gif) no-repeat 0px 0.5em } #toc #content H2 { FONT-WEIGHT: bold; FONT-SIZE: 90% } #toc #content P { FONT-SIZE: 90% } #toc #content SPAN.pagenum { FONT-WEIGHT: bold; FONT-SIZE: 70%; FLOAT: right } #home #content SPAN.pagenum { FONT-WEIGHT: bold; FONT-SIZE: 70%; FLOAT: right } #toc #content A.view { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN-BOTTOM: 1em } #toc #content H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 105%; BACKGROUND: url(/ncponc/images/dots.gif) repeat-x left bottom; = PADDING-BOTTOM: 3px; MARGIN: 0px; TEXT-TRANSFORM: uppercase; COLOR: = #000; PADDING-TOP: 3px; FONT-FAMILY: arial, helvetica, sans-serif } #toc #content H4.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #results #content H4.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #archive #content H4.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #home #content H4.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #results #content H4.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #archive #content H4.norm { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #toc #content H5 { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #toc #content DIV.sample { PADDING-RIGHT: 10px; PADDING-LEFT: 45px; BACKGROUND: = url(/clinicalpractice/images/free_small.gif) #f6f6f6 no-repeat 10px = 10px; MARGIN-BOTTOM: 20px; PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #toc #content DIV.no-image.sample { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #f6f6f6; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #toc #content DIV.sample H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; BACKGROUND: none = transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; = TEXT-TRANSFORM: none; PADDING-TOP: 0px } #toc #content DIV.sample P { FONT-SIZE: 90%; MARGIN: 0px } #toc #content P.author { FONT-SIZE: 90%; MARGIN: 0px } #results #content P.author { FONT-SIZE: 90%; MARGIN: 0px } #archive #content P.author { FONT-SIZE: 90%; MARGIN: 0px } #home #content P.author { FONT-SIZE: 90%; MARGIN: 0px } #results #content P.author { FONT-SIZE: 90%; MARGIN: 0px } #archive #content P.author { FONT-SIZE: 90%; MARGIN: 0px } #toc #content P.describe { FONT-SIZE: 90%; MARGIN: 0px 0px 1em } #toc #content P.journal { FONT-SIZE: 70%; MARGIN: 0.2em 0px } #results #content P.journal { FONT-SIZE: 70%; MARGIN: 0.2em 0px } #archive #content P.journal { FONT-SIZE: 70%; MARGIN: 0.2em 0px } #toc #content P.links { FONT-SIZE: 70%; MARGIN: 0px } #results #content .links { FONT-SIZE: 70%; MARGIN: 0px } #toc #content DIV.container { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left top; PADDING-BOTTOM: 0px; = MARGIN: 0px 0px 20px; PADDING-TOP: 0.1em } #toc #content DIV.container DIV { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BACKGROUND: url(/ncponc/images/dots.gif) = repeat-x left bottom; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 1em; = PADDING-TOP: 1em; BORDER-RIGHT-WIDTH: 0px } #toc #content DIV.container DIV.last { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: 0px 50%; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #toc #content DIV.container DIV.no-border { BORDER-BOTTOM-WIDTH: 0px } #toc #content DIV.container DIV A.seealso { MARGIN-TOP: 0.3em } #toc #content DIV.rss { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 80%; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 1em; PADDING-TOP: 0px } #toc #content IMG.rss-icon { MARGIN: 0.3em 0.5em 0.5em 0px; VERTICAL-ALIGN: middle; WIDTH: 14px; = HEIGHT: 15px } #toc #content P.rss-icon { MARGIN: 0px 0px 3em } #content A.rss { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 24px; BACKGROUND: = url(/common/images/icons/rss.gif) no-repeat left top; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 5px; PADDING-TOP: 0px } #toc #content DIV.aop-cite { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 80%; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left top; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 1em; PADDING-TOP: 1em; BORDER-RIGHT-WIDTH: 0px } #article #extract-login { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px = solid; MARGIN-TOP: 2em; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-COLOR: #f5f5f5 } #article #extract-login OL { FONT-WEIGHT: bold; MARGIN: 1em 0px 0px } #article #extract-login LI SPAN { DISPLAY: block; FONT-WEIGHT: normal } #article #extract-login LI { MARGIN: 0px 0px 0.5em } #article #extract-login H5 { MARGIN-BOTTOM: 1em } #article #content H5.dots { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left top; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 2em } #article #extract-login H6 { DISPLAY: block; MARGIN-BOTTOM: 1em } #article DIV.figure-table { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px = solid; MARGIN-TOP: 2em; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-COLOR: #fff } #article DIV.figure-table H5 { DISPLAY: block; MARGIN-BOTTOM: 10px } #article DIV.figure-table IMG.thumb { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 1px solid; FLOAT: left; = MARGIN: 10px 0px; BORDER-LEFT: #999 1px solid; BORDER-BOTTOM: #999 1px = solid } #article DIV.figure-table P { FONT-SIZE: 70%; MARGIN: 10px 0px 10px 160px } #article DIV.figure-table A.full { PADDING-RIGHT: 0px; MARGIN-TOP: 0px; DISPLAY: block; PADDING-LEFT: = 25px; FONT-SIZE: 70%; BACKGROUND: url(/common/images/full_figure.gif) = no-repeat 0px 0px; PADDING-BOTTOM: 4px; MARGIN-LEFT: 160px; PADDING-TOP: = 0px } #article DIV.figure-table A.download-pp { PADDING-RIGHT: 0px; MARGIN-TOP: 0px; DISPLAY: block; PADDING-LEFT: = 25px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/icons/fff/powerpoint.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 4px; MARGIN-LEFT: 160px; PADDING-TOP: 0px } #article DIV.boxes { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px = solid; MARGIN-TOP: 2em; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #999 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-COLOR: #fff } #article DIV.boxes H5 { DISPLAY: block; MARGIN-BOTTOM: 10px } #article DIV.boxes IMG.thumb { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 1px solid; FLOAT: left; = MARGIN: 10px 0px; BORDER-LEFT: #999 1px solid; BORDER-BOTTOM: #999 1px = solid } #article DIV.boxes P { FONT-SIZE: 70%; MARGIN: 10px 0px 10px 160px } #article DIV.boxes P.no_picture { FONT-SIZE: 70%; MARGIN: 10px 0px 0px } #article DIV.boxes A.full { MARGIN-TOP: 0px; DISPLAY: block; PADDING-LEFT: 25px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/full_figure.gif) no-repeat 0px 0px; = MARGIN-BOTTOM: 0em; PADDING-BOTTOM: 0.5em; MARGIN-LEFT: 160px } #article #web-links { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 10px; MARGIN-TOP: 2em; = PADDING-LEFT: 10px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; BACKGROUND-COLOR: #f6f6f6; = BORDER-RIGHT-WIDTH: 0px } #article #web-links H4 { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; = TEXT-TRANSFORM: uppercase } #article #web-links UL.web-links { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 90%; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } #article #cme { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 10px; MARGIN-TOP: 2em; = PADDING-LEFT: 10px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; BACKGROUND-COLOR: #f6f6f6; = BORDER-RIGHT-WIDTH: 0px } #article #cme H4 { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; = TEXT-TRANSFORM: uppercase } #article #cme A.q-link:link { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 1em; MARGIN: 0px; PADDING-TOP: 1em } #article #cme A.q-link:visited { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 10px; FONT-SIZE: 70%; = BACKGROUND: url(/common/images/arrow_blue.gif) no-repeat left center; = PADDING-BOTTOM: 1em; MARGIN: 0px; PADDING-TOP: 1em } #article #supplement-info { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 10px; MARGIN-TOP: 2em; = PADDING-LEFT: 10px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; BACKGROUND-COLOR: #f6f6f6; = BORDER-RIGHT-WIDTH: 0px } #article #supplement-info H4 { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px; = TEXT-TRANSFORM: uppercase } #article #supplement-info H5 { DISPLAY: block; FONT-WEIGHT: normal; FONT-SIZE: 70%; MARGIN: 1em 0px = 0px } #article #supplement-info H5 SPAN { FONT-WEIGHT: bold } #article #supplement-info P { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; FONT-SIZE: 70%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #article #supplement-info A.download-plugin { DISPLAY: block; PADDING-LEFT: 8px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/arrow_blue2_right.gif) no-repeat 0px 0.4em; = PADDING-BOTTOM: 10px; MARGIN: 1em 0px 0px } #article #supplement-info A.download-plugin:visited { BACKGROUND: url(/common/images/arrow_purple_right.gif) no-repeat 0px = 0.4em } #article #supplement-info A.download-plugin:hover { BACKGROUND: url(/common/images/arrow_red_right.gif) no-repeat 0px 0.4em } #article #content SPAN.journal { FONT-STYLE: italic } #article #content SPAN.jnumber { FONT-WEIGHT: bold } #article #content #more DIV.box { PADDING-RIGHT: 10px; MARGIN-TOP: 1px; PADDING-LEFT: 10px; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 20px; PADDING-TOP: 10px } #article #content #more DIV.container { PADDING-RIGHT: 0px; MARGIN-TOP: 1.5em; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #article #content #more P.intro { FONT-SIZE: 70%; MARGIN: 0px } #article #content #more H4.area { FONT-SIZE: 70%; MARGIN: 0px } #article #content #more P.title { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0px } #article #content #more P.source { FONT-SIZE: 70%; MARGIN: 0px } #article #content #more P.source SPAN.journal { FONT-STYLE: italic } #article #content #more P.seeall { FONT-SIZE: 70%; MARGIN: 0px } #article #content #more P.seeall A { PADDING-LEFT: 10px; BACKGROUND: url(/common/images/arrow_red.gif) = no-repeat left center; COLOR: #c03 } #article #content UL.bx { MARGIN-TOP: 0px; FONT-SIZE: 90%; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: = 8px; PADDING-TOP: 5px } #article #content LI.bxlist { MARGIN-TOP: 0px; PADDING-LEFT: 0px; MARGIN-LEFT: 0px; PADDING-TOP: 0px; = LIST-STYLE-TYPE: none } #article #content P.fnote { FONT-SIZE: 80% } #article-related #journal-header { BACKGROUND: #0066b3 } #article-related H1.page-header { FONT-WEIGHT: bold; FONT-SIZE: 120%; BACKGROUND: = url(/ncponc/images/dots.gif) repeat-x left bottom; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 1px; MARGIN: 15px 0px 10px; TEXT-TRANSFORM: none } #article-related H3.article-name { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related H2.from { FONT-SIZE: 90%; MARGIN: 1em 0px 0px; COLOR: #000 } #article-related P.sent-to { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN-BOTTOM: 0px } #article-related P.sendee { MARGIN-TOP: 0px; FONT-SIZE: 70% } #article-related P.with { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN-BOTTOM: 0px } #article-related P.message-header { MARGIN-TOP: 0px; FONT-SIZE: 70% } #article-related P.author { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 70%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related DIV.container-image { BORDER-LEFT-COLOR: #d3d3d3; BACKGROUND: #fff; BORDER-BOTTOM-COLOR: = #d3d3d3; BORDER-TOP-COLOR: #d3d3d3; BORDER-RIGHT-COLOR: #d3d3d3 } #article-related DIV.container-image-text { BORDER-LEFT-COLOR: #d3d3d3; BACKGROUND: #fff; BORDER-BOTTOM-COLOR: = #d3d3d3; BORDER-TOP-COLOR: #d3d3d3; BORDER-RIGHT-COLOR: #d3d3d3 } #article-related DIV.container-image-text H3.atl { MARGIN-TOP: 5px; FONT-SIZE: 90% } #article-related DIV.container-image-text P { MARGIN-TOP: 0px; FONT-SIZE: 90% } #article-related DIV.container-image-text SPAN.download { FONT-SIZE: 90% } #article-related A.back-to-article:link { BORDER-RIGHT: #eaeaea 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #eaeaea 1px solid; PADDING-LEFT: 20px; FONT-WEIGHT: normal; BACKGROUND: = url(/common/images/icons/back.gif) #fafafa no-repeat 5px center; = PADDING-BOTTOM: 2px; MARGIN: 10px 0px; TEXT-TRANSFORM: lowercase; = BORDER-LEFT: #eaeaea 1px solid; COLOR: #000; PADDING-TOP: 2px; = BORDER-BOTTOM: #eaeaea 1px solid; TEXT-DECORATION: none } #article-related A.back-to-article:visited { BORDER-RIGHT: #eaeaea 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #eaeaea 1px solid; PADDING-LEFT: 20px; FONT-WEIGHT: normal; BACKGROUND: = url(/common/images/icons/back.gif) #fafafa no-repeat 5px center; = PADDING-BOTTOM: 2px; MARGIN: 10px 0px; TEXT-TRANSFORM: lowercase; = BORDER-LEFT: #eaeaea 1px solid; COLOR: #000; PADDING-TOP: 2px; = BORDER-BOTTOM: #eaeaea 1px solid; TEXT-DECORATION: none } #article-related A.back-to-article:hover { BACKGROUND: url(/common/images/icons/back_hover.gif) no-repeat 5px = center; COLOR: #000; TEXT-DECORATION: none } #article-related H2.figure-title { MARGIN-BOTTOM: 0px } #article-related H2.appears { FONT-WEIGHT: normal; FONT-SIZE: 70%; MARGIN-BOTTOM: 0px } #article-related .journal .name { FONT-STYLE: italic } #article-related .journal .number { FONT-WEIGHT: bold } #article-related .container-image-text H2.pp { FONT-SIZE: 90%; MARGIN-BOTTOM: 0px } #article-related .container-image-text A.download-pp { PADDING-RIGHT: 0px; MARGIN-TOP: 0.5em; DISPLAY: block; PADDING-LEFT: = 25px; FONT-SIZE: 70%; BACKGROUND: = url(/common/images/icons/fff/powerpoint.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 4px; PADDING-TOP: 0px } #article-related H2.author { DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 90% } #article-related P.follows-h2 { DISPLAY: inline; FONT-SIZE: 90% } #article-related IMG.pict { FLOAT: left; MARGIN: 0.3em 0.5em 0.5em 0px; WIDTH: 120px; HEIGHT: 120px } #article-related TABLE.data CAPTION { FONT-WEIGHT: bold; FONT-SIZE: 90%; PADDING-BOTTOM: 0.5em; TEXT-ALIGN: = left } #article-related TABLE.data TD.image { TEXT-ALIGN: center } #article-related TABLE.data TD.image .credit { DISPLAY: block; MARGIN: 0.5em 0px; FONT-STYLE: italic; TEXT-ALIGN: left } #article-related DIV.prevnext { BORDER-LEFT-COLOR: #d3d3d3; BORDER-BOTTOM-COLOR: #d3d3d3; = BORDER-TOP-COLOR: #d3d3d3; BORDER-RIGHT-COLOR: #d3d3d3 } #article-related A.previous:link { BORDER-LEFT-COLOR: #d3d3d3; BORDER-BOTTOM-COLOR: #d3d3d3; = BORDER-TOP-COLOR: #d3d3d3; BORDER-RIGHT-COLOR: #d3d3d3 } #article-related A.previous:visited { BORDER-LEFT-COLOR: #d3d3d3; BORDER-BOTTOM-COLOR: #d3d3d3; = BORDER-TOP-COLOR: #d3d3d3; BORDER-RIGHT-COLOR: #d3d3d3 } #article-related A.next:link { BORDER-LEFT-COLOR: #d3d3d3; BORDER-BOTTOM-COLOR: #d3d3d3; = BORDER-TOP-COLOR: #d3d3d3; BORDER-RIGHT-COLOR: #d3d3d3 } #article-related A.next:visited { BORDER-LEFT-COLOR: #d3d3d3; BORDER-BOTTOM-COLOR: #d3d3d3; = BORDER-TOP-COLOR: #d3d3d3; BORDER-RIGHT-COLOR: #d3d3d3 } #article-related DIV.container-figtab { BORDER-LEFT-COLOR: #d3d3d3; BORDER-BOTTOM-COLOR: #d3d3d3; = BORDER-TOP-COLOR: #d3d3d3; BACKGROUND-COLOR: #fff; BORDER-RIGHT-COLOR: = #d3d3d3 } #article-related H3.norm { FONT-SIZE: 90%; MARGIN: 1em 0px 0px; COLOR: #000 } #article-related CITE.main { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 70%; = PADDING-BOTTOM: 1.5em; MARGIN: 0px; PADDING-TOP: 0px; FONT-STYLE: normal } #article-related OL.response { PADDING-RIGHT: 0px; PADDING-LEFT: 25px; FONT-SIZE: 70%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } #article-related OL.response LI { MARGIN: 5px 0px } #article-related CITE.norm { FONT-STYLE: normal } #article-related DIV.container-sendfriend { BORDER-RIGHT: #d3d3d3 1px solid; BORDER-TOP: #d3d3d3 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #d3d3d3 1px solid; BORDER-BOTTOM: #d3d3d3 = 1px solid } #article-related DIV.container-more { BORDER-RIGHT: #d3d3d3 1px solid; BORDER-TOP: #d3d3d3 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #d3d3d3 1px solid; BORDER-BOTTOM: #d3d3d3 = 1px solid } #article-related DIV.container-plugins { BORDER-RIGHT: #d3d3d3 1px solid; BORDER-TOP: #d3d3d3 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #d3d3d3 1px solid; BORDER-BOTTOM: #d3d3d3 = 1px solid } #article-related DIV.container-more2 { BORDER-RIGHT: #d3d3d3 1px solid; BORDER-TOP: #d3d3d3 1px solid; = BACKGROUND: #fff; BORDER-LEFT: #d3d3d3 1px solid; BORDER-BOTTOM: #d3d3d3 = 1px solid } #article-related P.essential { COLOR: #999999 } #article-related INPUT { BACKGROUND: #ffffff } #article-related INPUT.essential { BACKGROUND: #ffffe3 } #article-related DIV.container-more2 { BORDER-BOTTOM-WIDTH: 0px } #article-related DIV.container-sendfriend { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: #f6f6f6; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } #article-related DIV.wrapper { MARGIN-BOTTOM: 1em } #article-related H3.area { FONT-WEIGHT: bold; FONT-SIZE: 100%; MARGIN: 0px; TEXT-TRANSFORM: none } #article-related H3.atl { FONT-WEIGHT: normal; FONT-SIZE: 70%; MARGIN: 0px } #article-related P.author-search { FONT-SIZE: 70%; MARGIN: 0.5em 0px } #article-related DIV.text { FLOAT: left; WIDTH: 210px; TEXT-ALIGN: right } #article-related DIV.text P { FONT-SIZE: 70%; MARGIN: 0px } #article-related UL.download { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 90%; PADDING-BOTTOM: = 15px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #article-related UL.download LI { MARGIN: 5px 0px } #article-related UL.download A { PADDING-RIGHT: 0px; PADDING-LEFT: 23px; BACKGROUND: = url(/common/images/icons/fff/export.gif) no-repeat left center; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px } #contact-team #content LABEL { FONT-WEIGHT: bold; FONT-SIZE: 90% } #contact-team #content DIV.text P { FONT-SIZE: 70%; MARGIN: 0px } #contact-team #content .wrapper INPUT { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; MARGIN: 0.2em 0px 0.5em; WIDTH: auto; PADDING-TOP: 0px } #contact-team #content TEXTAREA { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; MARGIN: 0.2em 0px 0.5em; WIDTH: auto; PADDING-TOP: 0px } #contact-team #content .wrapper INPUT { WIDTH: 100% } #contact-team #content TEXTAREA { WIDTH: 100% } #contact-team #content INPUT.friend { CLEAR: both; MARGIN: 1em 0px 0px } #contact-team #content FORM { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px; BACKGROUND-COLOR: #f6f6f6 } #contact-team #content P { FONT-SIZE: 90% } #contact-team #content FORM P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 1em } #contact-team #content FIELDSET#message-type { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0.5em 0px 1em; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #contact-team #content FIELDSET#message-type DIV.radio { CLEAR: left; FLOAT: left; WIDTH: 10px; TEXT-ALIGN: left } #contact-team #content FIELDSET#message-type DIV.radiotext LABEL { FONT-WEIGHT: normal; MARGIN-LEFT: 10px } #contact-team #content FIELDSET INPUT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; VERTICAL-ALIGN: middle; PADDING-TOP: 0px } #contact-team #content FIELDSET LABEL { VERTICAL-ALIGN: middle } #contact-team #content DIV.left { CLEAR: left; FLOAT: left; WIDTH: 48% } #contact-team #content DIV.right { FLOAT: right; WIDTH: 48% } #contact-team #content DIV.left P { MARGIN: 0px 0px 1em } #contact-team #content DIV.right P { MARGIN: 0px 0px 1em } #contact-team #content H3 { FONT-SIZE: 90%; MARGIN: 0px } #contact-team #content TD { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px; TEXT-ALIGN: left } #contact-team #content TH { TEXT-ALIGN: left } #contact-team #content .center { TEXT-ALIGN: center } #contact-team #content H2.page { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; BACKGROUND: url(/clinicalpractice/images/dotted.gif) repeat-x 0px = 0px; PADDING-BOTTOM: 0px; MARGIN: 1em 0px; COLOR: #000; PADDING-TOP: = 0.8em } #contact-team #content H2.norm { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: bold; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 105%; BACKGROUND: = url(/ncpcardio/images/dots.gif) repeat-x left bottom; = BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 3px; MARGIN: 0px; = TEXT-TRANSFORM: uppercase; COLOR: #000; PADDING-TOP: 3px; FONT-FAMILY: = arial, helvetica, sans-serif; BORDER-RIGHT-WIDTH: 0px } H1.home { FONT-WEIGHT: bold; FONT-SIZE: 90%; BACKGROUND: none transparent scroll = repeat 0% 0% } #home .boxrow H2 { FONT-WEIGHT: bold; FONT-SIZE: 80%; MARGIN: 0px } #toc .boxrow H2 { FONT-WEIGHT: bold; FONT-SIZE: 80%; MARGIN: 0px } #home .middots { BACKGROUND: url(/clinicalpractice/images/dottedv.gif) repeat-y center = top } #toc .middots { BACKGROUND: url(/clinicalpractice/images/dottedv.gif) repeat-y center = top } #home .boxrow { BACKGROUND: url(/clinicalpractice/images/dotted.gif) repeat-x center = top; MARGIN-BOTTOM: 1% } #toc .boxrow { BACKGROUND: url(/clinicalpractice/images/dotted.gif) repeat-x center = top; MARGIN-BOTTOM: 1% } #home .boxrow .l { FLOAT: left; WIDTH: 48% } #toc .boxrow .l { FLOAT: left; WIDTH: 48% } #home .boxrow .r { FLOAT: right; WIDTH: 48% } #toc .boxrow .r { FLOAT: right; WIDTH: 48% } #home .boxrow P { FONT-SIZE: 90% } #toc .boxrow P { FONT-SIZE: 90% } #toc UL.linelinks LI { DISPLAY: inline; FONT-SIZE: 90%; LIST-STYLE-TYPE: none } #toc .sponsor_message { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; BACKGROUND: #f6f6f6; = MARGIN-BOTTOM: 20px; PADDING-BOTTOM: 5px; PADDING-TOP: 5px } #toc IMG.sponsor_logo { FLOAT: right } #toc UL.weblinks LI { FONT-SIZE: 90%; PADDING-BOTTOM: 10px; LIST-STYLE-TYPE: none } #toc UL.dates LI.year { PADDING-RIGHT: 2px; DISPLAY: block; PADDING-LEFT: 2px; FONT-SIZE: 90%; = BACKGROUND: #f6f6f6; LIST-STYLE-IMAGE: url(none); PADDING-BOTTOM: 2px; = MARGIN: 0px 0px 5px; PADDING-TOP: 2px; LIST-STYLE-TYPE: none } #toc UL.dates { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #toc A.col_link { FONT-SIZE: 90%; PADDING-BOTTOM: 94px } #toc #content IMG.colcover { FLOAT: left; MARGIN-BOTTOM: 5px; MARGIN-RIGHT: 5px } #toc #content IMG.supcover { FLOAT: left; MARGIN-BOTTOM: 5px; MARGIN-RIGHT: 5px } DIV.journaldetails { MARGIN-TOP: 10px } DIV.journaldetails P { FONT-SIZE: 90%; MARGIN: 1em 0px 0px } #content DIV.authorlogin LEGEND { FONT-WEIGHT: bold } #content DIV.authorlogin LEGEND { FONT-SIZE: 100%; COLOR: #812991 } #content DIV.authorlist H2.authorsection { FONT-SIZE: 100%; COLOR: #812991 } #content DIV.authorlist H2.authorsection { PADDING-LEFT: 15px; BACKGROUND: = url(/ncpcardio/images/grey_arrow_list.gif) no-repeat 0.2em 50%; = MARGIN-BOTTOM: 5px } #content DIV.authorlist UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } * HTML #content DIV.authorlist LI.greyback { BORDER-BOTTOM: #fff 1px solid } #content DIV.authorlist LI.greyback { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: #fafafa; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 10px; PADDING-TOP: 0px } #content DIV.authorlist LI.link { PADDING-LEFT: 15px; FONT-SIZE: 80%; PADDING-BOTTOM: 10px } #content DIV.authorlogin DIV.formbox { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 2px; WIDTH: 50%; PADDING-TOP: 0px } #content DIV.authorlogin DIV.formbox LABEL { MARGIN-TOP: 5px; DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 80%; = MARGIN-BOTTOM: 5px; COLOR: #666 } #content DIV.authorlogin DIV.formbox INPUT.butt { MARGIN-TOP: 5px; FONT-SIZE: 80%; FLOAT: left; MARGIN-RIGHT: 5px } #content DIV.authorlogin FIELDSET { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } #content DIV.authorlogin DIV.formhelptext { FLOAT: right; WIDTH: 47% } #content DIV.authorlogin DIV.formhelptext P.formhelp { PADDING-LEFT: 25px; FONT-SIZE: 100%; BACKGROUND: = url(/ncpcardio/images/qmark.gif) no-repeat 0.2em 50%; COLOR: #812991 } .scp { FONT-SIZE: 70%; FONT-VARIANT: small-caps } #ncpBox { BORDER-RIGHT: #00a8cb 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #00a8cb 1px solid; PADDING-LEFT: 0px; FONT-SIZE: 70%; BACKGROUND: = url(/clinicalpractice/images/ncpbox_bg.gif) repeat-x left bottom; = MARGIN-BOTTOM: 2em; PADDING-BOTTOM: 0px; BORDER-LEFT: #00a8cb 1px solid; = PADDING-TOP: 0px; BORDER-BOTTOM: #00a8cb 1px solid } #boxContent { MARGIN: 7px } #boxContent UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 15px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #boxContent UL LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } #extranav A.topten:link { PADDING-RIGHT: 0px; PADDING-LEFT: 22px; BACKGROUND: = url(/aj/images/icon_topten.gif) no-repeat left bottom; PADDING-BOTTOM: = 2px; PADDING-TOP: 10px } #extranav A.topten:visited { PADDING-RIGHT: 0px; PADDING-LEFT: 22px; BACKGROUND: = url(/aj/images/icon_topten.gif) no-repeat left bottom; PADDING-BOTTOM: = 2px; PADDING-TOP: 10px } #extranav A.topten:hover { PADDING-RIGHT: 0px; PADDING-LEFT: 22px; BACKGROUND: = url(/aj/images/icon_topten.gif) no-repeat left bottom; PADDING-BOTTOM: = 2px; PADDING-TOP: 10px } #topten #content DIV.container DIV.last { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 1em; = PADDING-TOP: 1em; BORDER-RIGHT-WIDTH: 0px } #topten #content P.intro { FONT-SIZE: 90% } #topten #content H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 90%; PADDING-BOTTOM: 3px; MARGIN: 0px 0px 1em; COLOR: #db1a21; = PADDING-TOP: 3px } #topten #content OL P { FONT-SIZE: 80%; MARGIN: 0.2em 0px } #topten #content SPAN.pagenum { PADDING-RIGHT: 10px; FONT-WEIGHT: bold; FONT-SIZE: 70%; FLOAT: right } #topten #content OL.topten P.articlelinks { FONT-SIZE: 80%; MARGIN: 0.5em 0px 0.6em } #content OL.topten H3 { FONT-WEIGHT: bold; FONT-SIZE: 100%; BORDER-BOTTOM-WIDTH: 0px; MARGIN: = 0.3em 0px; TEXT-TRANSFORM: uppercase } #topten OL.topten H4 { FONT-WEIGHT: bold; FONT-SIZE: 90%; MARGIN: 0.3em 0px; WIDTH: 90% } #topten OL.topten H5 { FONT-WEIGHT: normal; FONT-SIZE: 90%; MARGIN: 0.3em 0px } #topten OL.topten A.fulltext { FONT-WEIGHT: bold } * HTML #content OL.topten { TEXT-ALIGN: left } #content OL.topten { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: #fafafa; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none } #content OL.topten LI.topten_1 { BACKGROUND: url(/common/images/topten/01.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_2 { BACKGROUND: url(/common/images/topten/02.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_3 { BACKGROUND: url(/common/images/topten/03.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_4 { BACKGROUND: url(/common/images/topten/04.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_5 { BACKGROUND: url(/common/images/topten/05.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_6 { BACKGROUND: url(/common/images/topten/06.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_7 { BACKGROUND: url(/common/images/topten/07.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_8 { BACKGROUND: url(/common/images/topten/08.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_9 { BACKGROUND: url(/common/images/topten/09.gif) no-repeat 98.5% 10px } #content OL.topten LI.topten_10 { BACKGROUND: url(/common/images/topten/10.gif) no-repeat 98.5% 10px } #content OL.topten { PADDING-RIGHT: 0px; BORDER-TOP: #e7e7e7 1px solid; PADDING-LEFT: 0px; = BACKGROUND: #fafafa; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = LIST-STYLE-TYPE: none } #content OL.topten .container { PADDING-RIGHT: 7px; PADDING-LEFT: 7px; PADDING-BOTTOM: 7px; MARGIN: = 0px; PADDING-TOP: 7px; BORDER-BOTTOM: #e7e7e7 1px solid } #extranav A.topten:link { BORDER-TOP-STYLE: none } #extranav A.topten:visited { BORDER-TOP-STYLE: none } H5.numbers { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: normal; FONT-SIZE: = 90%; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } P.numbers { MARGIN: 0px 0px 0px 20px } UL.numbers { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 10px; MARGIN: 1em 0px 0px 20px; PADDING-TOP: 0px; = LIST-STYLE-TYPE: none } #articlenav LI.sermo { MARGIN-TOP: 0px; PADDING-LEFT: 0px; MARGIN-LEFT: 0px; PADDING-TOP: 0px } #articlenav LI.sermo IMG { MARGIN-LEFT: 6px; VERTICAL-ALIGN: middle } #articlenav LI.sermo FORM { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } #articlenav LI.sermo A { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; = BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 6px; = PADDING-TOP: 0px } INPUT.sermo-submit:hover { TEXT-DECORATION: underline } INPUT.sermo-submit { PADDING-RIGHT: 0px; BACKGROUND-POSITION: 4px center; PADDING-LEFT: 11%; = FONT-SIZE: 70%; PADDING-BOTTOM: 3px; PADDING-TOP: 3px } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/ncpneuro/style/site.css #hdr .user-services .li1 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_account_pink.gif) } #hdr .user-services .li2 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_ealert_pink.gif) } #hdr .user-services .li3 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_register_pink.gif) } #hdr .user-services .li4 A { BACKGROUND-IMAGE: = url(/common/includes/header/images/icons/01/icon_subscribe_pink.gif) } #hdr .user-services .us-link A:link { COLOR: #3366cc } #hdr .user-services .us-link A:visited { COLOR: #3366cc } #hdr .user-services .us-link A:hover { COLOR: #cc0033 } .home .jn-home A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .home .jn-home A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .aop .jn-aop A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .aop .jn-aop A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .about-aop .jn-aop A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .about-aop .jn-aop A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .issue .jn-issue A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .issue .jn-issue A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .archive .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .archive .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .subjects .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .subjects .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .issues .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .issues .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .article-types .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .article-types .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .authors .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .authors .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .cme .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .cme .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .web-focuses .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .web-focuses .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .supplements .jn-archive A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .supplements .jn-archive A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .about-the-journal .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .about-the-journal .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .aims-and-scope .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .aims-and-scope .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .editorial-policies .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .editorial-policies .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .author-instructions .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .author-instructions .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .facts-and-figures .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .facts-and-figures .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .commercial-opportunities .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .commercial-opportunities .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .information-for-librarians .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .information-for-librarians .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .contact-the-journal .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .contact-the-journal .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .pda-services .jn-about-the-journal A:link { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .pda-services .jn-about-the-journal A:visited { COLOR: #fff; BORDER-BOTTOM: #b3097c 1px solid; BACKGROUND-COLOR: = #b3097c } .about-the-journal .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .about-the-journal .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .top-ten .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .top-ten .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .aims-and-scope .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .aims-and-scope .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .editorial-policies .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .editorial-policies .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .author-instructions .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .author-instructions .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .facts-and-figures .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .facts-and-figures .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .commercial-opportunities .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .commercial-opportunities .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .information-for-librarians .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .information-for-librarians .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .contact-the-journal .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .contact-the-journal .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .pda-services .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .pda-services .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .aop .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .aop .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .about-aop .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .about-aop .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .archive .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .archive .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .subjects .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .subjects .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .article-types .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .article-types .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .authors .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .authors .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .cme .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .cme .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .web-focuses .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .web-focuses .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .supplements .subnav A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .supplements .subnav A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots2.gif) #ece5ea no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #000; BORDER-RIGHT-WIDTH: 0px } .top-ten .jn-top-ten A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .top-ten .jn-top-ten A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .aims-and-scope .jn-aims-and-scope A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .aims-and-scope .jn-aims-and-scope A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .editorial-policies .jn-editorial-policies A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .editorial-policies .jn-editorial-policies A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .author-instructions .jn-author-instructions A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .author-instructions .jn-author-instructions A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .facts-and-figures .jn-facts-and-figures A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .facts-and-figures .jn-facts-and-figures A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .commercial-opportunities .jn-commercial-opportunities A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .commercial-opportunities .jn-commercial-opportunities A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .information-for-librarians .jn-information-for-librarians A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .information-for-librarians .jn-information-for-librarians A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .contact-the-journal .jn-contact-the-journal A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .contact-the-journal .jn-contact-the-journal A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .pda-services .jn-pda-services A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .pda-services .jn-pda-services A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .about-aop .jn-about-aop A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .about-aop .jn-about-aop A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .subjects .jn-subjects A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .subjects .jn-subjects A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .issues .jn-issues A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .issues .jn-issues A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .article-types .jn-article-types A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .article-types .jn-article-types A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .authors .jn-authors A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .authors .jn-authors A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .cme .jn-cme A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .cme .jn-cme A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .web-focuses .jn-web-focuses A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .web-focuses .jn-web-focuses A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .supplements .jn-web-focuses A:link { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .supplements .jn-web-focuses A:visited { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: = url(/common/images/nav_dots1.gif) #b3097c no-repeat 5px 5px; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #fff! important; BORDER-RIGHT-WIDTH: = 0px } .home .subnav { DISPLAY: none } .archive .jn-aop .subnav { DISPLAY: none } .archive .jn-about-the-journal .subnav { DISPLAY: none } .issues .jn-aop .subnav { DISPLAY: none } .issues .jn-about-the-journal .subnav { DISPLAY: none } .article-types .jn-aop .subnav { DISPLAY: none } .article-types .jn-about-the-journal .subnav { DISPLAY: none } .subjects .jn-aop .subnav { DISPLAY: none } .subjects .jn-about-the-journal .subnav { DISPLAY: none } .authors .jn-aop .subnav { DISPLAY: none } .authors .jn-about-the-journal .subnav { DISPLAY: none } .cme .jn-aop .subnav { DISPLAY: none } .cme .jn-about-the-journal .subnav { DISPLAY: none } .web-focuses .jn-aop .subnav { DISPLAY: none } .web-focuses .jn-about-the-journal .subnav { DISPLAY: none } .supplements .jn-aop .subnav { DISPLAY: none } .supplements .jn-about-the-journal .subnav { DISPLAY: none } .aop .jn-archive .subnav { DISPLAY: none } .aop .jn-about-the-journal .subnav { DISPLAY: none } .about-aop .jn-archive .subnav { DISPLAY: none } .about-aop .jn-about-the-journal .subnav { DISPLAY: none } .issue .subnav { DISPLAY: none } .about-the-journal .jn-archive .subnav { DISPLAY: none } .about-the-journal .jn-aop .subnav { DISPLAY: none } .top-ten .jn-archive .subnav { DISPLAY: none } .top-ten .jn-aop .subnav { DISPLAY: none } .aims-and-scope .jn-archive .subnav { DISPLAY: none } .aims-and-scope .jn-aop .subnav { DISPLAY: none } .editorial-policies .jn-archive .subnav { DISPLAY: none } .editorial-policies .jn-aop .subnav { DISPLAY: none } .author-instructions .jn-archive .subnav { DISPLAY: none } .author-instructions .jn-aop .subnav { DISPLAY: none } .facts-and-figures .jn-archive .subnav { DISPLAY: none } .facts-and-figures .jn-aop .subnav { DISPLAY: none } .commercial-opportunities .jn-archive .subnav { DISPLAY: none } .commercial-opportunities .jn-aop .subnav { DISPLAY: none } .information-for-librarians .jn-archive .subnav { DISPLAY: none } .information-for-librarians .jn-aop .subnav { DISPLAY: none } .contact-the-journal .jn-archive .subnav { DISPLAY: none } .contact-the-journal .jn-aop .subnav { DISPLAY: none } .pda-services .jn-archive .subnav { DISPLAY: none } .pda-services .jn-aop .subnav { DISPLAY: none } MAP.journal-nav UL LI A.on { BORDER-BOTTOM-COLOR: #b3097c } MAP.journal-nav UL LI A:hover { BORDER-BOTTOM-COLOR: #b3097c } MAP.journal-nav UL LI UL.subnav { BORDER-BOTTOM-COLOR: #bac6c1 } MAP.journal-nav UL LI UL.subnav LI { BACKGROUND-COLOR: #ece5ea } MAP.journal-nav UL LI UL.subnav LI A { BACKGROUND-COLOR: #ece5ea } #login A:hover { COLOR: #b3097c } DIV.account-buttons A:hover { COLOR: #b3097c } #search A.adsearch:hover { COLOR: #b3097c } .button { BACKGROUND-COLOR: #b3097c } MAP.journal-nav UL LI A:hover { BACKGROUND-COLOR: #b3097c } MAP.journal-nav UL LI A.on { BACKGROUND-COLOR: #b3097c } MAP.journal-nav UL LI A.on:visited { BACKGROUND-COLOR: #b3097c } MAP.journal-nav UL LI UL.subnav LI.on { BACKGROUND-COLOR: #b3097c } MAP.journal-nav UL LI UL.subnav LI.on A { BACKGROUND-COLOR: #b3097c } MAP.journal-nav UL LI UL.subnav LI A:hover { BACKGROUND-COLOR: #b3097c } UL.npg-resources A:hover { BACKGROUND-COLOR: #b3097c } H1.society-resources { BACKGROUND-COLOR: #b3097c } UL.society-resources A:hover { BACKGROUND-COLOR: #b3097c } #article-related #journal-header { BACKGROUND-COLOR: #b3097c } #article-related A.back-to-article:hover { BACKGROUND-COLOR: #b3097c } #extranav #articlenav H2 { BACKGROUND-COLOR: #b3097c } #extranav #articlenav-toc { BACKGROUND-COLOR: #b3097c } #info #content H2.block { BACKGROUND-COLOR: #b3097c } #ncpBox { BORDER-RIGHT: #b3097c 1px solid; BORDER-TOP: #b3097c 1px solid; = BORDER-LEFT: #b3097c 1px solid; BORDER-BOTTOM: #b3097c 1px solid } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/restrict_width/966px.css #head-er .accessibility-login { MAX-WIDTH: 966px; MARGIN: 0px auto } #head-er .image-user-services { MAX-WIDTH: 966px; MARGIN: 0px auto } #head-er .publications-search { MAX-WIDTH: 966px; MARGIN: 0px auto } DIV.footer-constrain { MAX-WIDTH: 966px; MARGIN: 0px auto } * HTML #head-er .accessibility-login-wrap { TEXT-ALIGN: center } * HTML #head-er .image-user-services-wrap { TEXT-ALIGN: center } * HTML #head-er .publications-search-wrap { TEXT-ALIGN: center } * HTML DIV.footer-constrain { TEXT-ALIGN: center } #breadcrumb { MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } #constrain { CLEAR: both; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; TEXT-ALIGN: center } .constrain-outer { CLEAR: both; PADDING-RIGHT: 1%; PADDING-LEFT: 1%; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; TEXT-ALIGN: center } #constrain .constrain { MAX-WIDTH: 966px; MARGIN-LEFT: auto; MARGIN-RIGHT: auto; TEXT-ALIGN: = left } .constrain-outer .constrain { MAX-WIDTH: 966px; MARGIN-LEFT: auto; MARGIN-RIGHT: auto; TEXT-ALIGN: = left } BODY DIV.margin-provider#content { MARGIN: 0px } #content-journalnav { MARGIN-LEFT: 0px } #content-extranav { MARGIN-RIGHT: 0px } #extranav { MARGIN-RIGHT: 0px } #journalnav { MARGIN-LEFT: 0px } #article-related #content { MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/style/print.css #header { DISPLAY: none } #head-er { DISPLAY: none } #breadcrumb { DISPLAY: none } .no-css { DISPLAY: none } #journalnav { DISPLAY: none } #journal-header { DISPLAY: none } #extranav { DISPLAY: none } #footer { DISPLAY: none } #foot-er { DISPLAY: none } #footer-sponsor { DISPLAY: none } #npglogo { DISPLAY: none } #hdr .publications-search { DISPLAY: none } #hdr .leaderboard-links { DISPLAY: none } #hdr .logon { DISPLAY: none } #hdr .header-nav { DISPLAY: none } #hdr #header-nav { DISPLAY: none } #ftr { DISPLAY: none } #hdr .journal-header IMG { DISPLAY: block! important } #content-journalnav { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: 100%; PADDING-TOP: 0px } #content { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: 100%; PADDING-TOP: 0px } #footer-copyright { CLEAR: both; BORDER-TOP: black 2px solid; MARGIN-TOP: 15px; FONT-SIZE: = 90%; COLOR: #999; PADDING-TOP: 15px } #footer-copyright A { FONT-WEIGHT: normal; COLOR: #000; TEXT-DECORATION: none } #footer-copyright .non-copyright { DISPLAY: none } .print-header { MARGIN-BOTTOM: 15px; PADDING-BOTTOM: 15px; BORDER-BOTTOM: black 2px = solid } BODY { FONT-SIZE: 12pt; BACKGROUND: #fff; COLOR: #000; FONT-FAMILY: georgia, = serif } H1 { FONT-SIZE: 16pt } H2 { FONT-SIZE: 14pt } H3 { FONT-SIZE: 12pt } H4 { FONT-SIZE: 12pt } H5 { FONT-SIZE: 12pt } H6 { FONT-SIZE: 12pt } A:link { FONT-WEIGHT: bold; BACKGROUND: none transparent scroll repeat 0% 0%; = COLOR: #009; TEXT-DECORATION: underline } A:visited { FONT-WEIGHT: bold; BACKGROUND: none transparent scroll repeat 0% 0%; = COLOR: #009; TEXT-DECORATION: underline } #content A:link:unknown { FONT-WEIGHT: normal; content: " (" attr(href) ") " } #content A:visited:unknown { FONT-WEIGHT: normal; content: " (" attr(href) ") " } #article #content DIV BLOCKQUOTE { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #000 = 1px solid; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; MARGIN: 1.26em = 0px; BORDER-LEFT: #000 1px solid; PADDING-TOP: 0.5em; BORDER-BOTTOM: = #000 1px solid; TEXT-ALIGN: center } #article #content DIV BLOCKQUOTE P { MARGIN: 0px } #article #content DIV BLOCKQUOTE IMG { DISPLAY: none } .backtotop { DISPLAY: none } .back-to-article { DISPLAY: none } .prevnext { DISPLAY: none } * HTML #article-related TABLE.data { FONT-SIZE: 7pt; WIDTH: 100% } #article-related TABLE.data { FONT-SIZE: 7pt; WIDTH: 100% } #article-related TABLE.data { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #999 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: = #999 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #999 1px solid; = BORDER-COLLAPSE: collapse; TEXT-ALIGN: left } #article-related TABLE.data THEAD { FONT-WEIGHT: bold } #article-related TABLE.data THEAD TH { BORDER-RIGHT: #999 1px solid; BACKGROUND: #f6f6f6; BORDER-LEFT: #999 = 1px solid } #article-related TABLE.data THEAD TH.colspan { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 0px solid; BORDER-LEFT: = #999 1px solid; BORDER-BOTTOM: #999 1px solid; TEXT-ALIGN: center } #article-related TABLE.data THEAD TH.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TD.last { BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY { BORDER-TOP: #999 1px solid; BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TBODY TR { BACKGROUND-COLOR: #f6f6f6 } #article-related TABLE.data TBODY TR.odd { BACKGROUND-COLOR: #fff } #article-related TABLE.data TBODY TD { BORDER-RIGHT: #999 1px solid; BORDER-BOTTOM: #999 1px solid } #article-related TABLE.data TFOOT { POSITION: relative } #article-related TABLE.data TFOOT TD { FONT-SIZE: 7pt; BACKGROUND-COLOR: #fff } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/includes/header/03/style/ie-specific/lte-ie-7.css #hdr .pub1 A { MARGIN-TOP: 7px; DISPLAY: block } #hdr .list-container { FLOAT: left } #hdr .list-container UL { FLOAT: left } #hdr .user-services .us-link A:link { PADDING-BOTTOM: 2px; PADDING-TOP: 0px } #hdr .user-services .us-link A:visited { PADDING-BOTTOM: 2px; PADDING-TOP: 0px } #hdr .list-container UL.list1 { MARGIN-LEFT: 0px; MARGIN-RIGHT: 4px } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/clinicalpractice/style/ie-specific/lte-ie-7.css P.numbers { FLOAT: left } P.numbers { MARGIN-LEFT: 20px } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/includes/header/03/style/ie-specific/ie-7.css #hdr .list-container UL { WIDTH: 114px } #hdr .list-container UL.list1 { MARGIN-RIGHT: 5px } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/common/style/ie-specific/ie-7.css BODY { FONT-SIZE: 89% } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.nature.com/clinicalpractice/style/ie-specific/ie-7.css #home .finalrow { MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 2% } ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/scripts/jquery.js /*=0A= * jQuery 1.2.1 - New Wave Javascript=0A= *=0A= * Copyright (c) 2007 John Resig (jquery.com)=0A= * Dual licensed under the MIT (MIT-LICENSE.txt)=0A= * and GPL (GPL-LICENSE.txt) licenses.=0A= *=0A= * $Date: 2007-09-16 23:42:06 -0400 (Sun, 16 Sep 2007) $=0A= * $Rev: 3353 $=0A= */=0A= (function(){if(typeof jQuery!=3D"undefined")var _jQuery=3DjQuery;var = jQuery=3Dwindow.jQuery=3Dfunction(selector,context){return this = instanceof jQuery?this.init(selector,context):new = jQuery(selector,context);};if(typeof $!=3D"undefined")var = _$=3D$;window.$=3DjQuery;var = quickExpr=3D/^[^<]*(<(.|\s)+>)[^>]*$|^#(\w+)$/;jQuery.fn=3DjQuery.prototy= pe=3D{init:function(selector,context){selector=3Dselector||document;if(ty= peof selector=3D=3D"string"){var = m=3DquickExpr.exec(selector);if(m&&(m[1]||!context)){if(m[1])selector=3Dj= Query.clean([m[1]],context);else{var = tmp=3Ddocument.getElementById(m[3]);if(tmp)if(tmp.id!=3Dm[3])return = jQuery().find(selector);else{this[0]=3Dtmp;this.length=3D1;return = this;}else=0A= selector=3D[];}}else=0A= return new jQuery(context).find(selector);}else = if(jQuery.isFunction(selector))return new = jQuery(document)[jQuery.fn.ready?"ready":"load"](selector);return = this.setArray(selector.constructor=3D=3DArray&&selector||(selector.jquery= ||selector.length&&selector!=3Dwindow&&!selector.nodeType&&selector[0]!=3D= undefined&&selector[0].nodeType)&&jQuery.makeArray(selector)||[selector])= ;},jquery:"1.2.1",size:function(){return = this.length;},length:0,get:function(num){return = num=3D=3Dundefined?jQuery.makeArray(this):this[num];},pushStack:function(= a){var ret=3DjQuery(a);ret.prevObject=3Dthis;return = ret;},setArray:function(a){this.length=3D0;Array.prototype.push.apply(thi= s,a);return this;},each:function(fn,args){return = jQuery.each(this,fn,args);},index:function(obj){var = pos=3D-1;this.each(function(i){if(this=3D=3Dobj)pos=3Di;});return = pos;},attr:function(key,value,type){var = obj=3Dkey;if(key.constructor=3D=3DString)if(value=3D=3Dundefined)return = this.length&&jQuery[type||"attr"](this[0],key)||undefined;else{obj=3D{};o= bj[key]=3Dvalue;}return this.each(function(index){for(var prop in = obj)jQuery.attr(type?this.style:this,prop,jQuery.prop(this,obj[prop],type= ,index,prop));});},css:function(key,value){return = this.attr(key,value,"curCSS");},text:function(e){if(typeof = e!=3D"object"&&e!=3Dnull)return = this.empty().append(document.createTextNode(e));var = t=3D"";jQuery.each(e||this,function(){jQuery.each(this.childNodes,functio= n(){if(this.nodeType!=3D8)t+=3Dthis.nodeType!=3D1?this.nodeValue:jQuery.f= n.text([this]);});});return = t;},wrapAll:function(html){if(this[0])jQuery(html,this[0].ownerDocument).= clone().insertBefore(this[0]).map(function(){var = elem=3Dthis;while(elem.firstChild)elem=3Delem.firstChild;return = elem;}).append(this);return this;},wrapInner:function(html){return = this.each(function(){jQuery(this).contents().wrapAll(html);});},wrap:func= tion(html){return = this.each(function(){jQuery(this).wrapAll(html);});},append:function(){re= turn = this.domManip(arguments,true,1,function(a){this.appendChild(a);});},prepe= nd:function(){return = this.domManip(arguments,true,-1,function(a){this.insertBefore(a,this.firs= tChild);});},before:function(){return = this.domManip(arguments,false,1,function(a){this.parentNode.insertBefore(= a,this);});},after:function(){return = this.domManip(arguments,false,-1,function(a){this.parentNode.insertBefore= (a,this.nextSibling);});},end:function(){return = this.prevObject||jQuery([]);},find:function(t){var = data=3DjQuery.map(this,function(a){return jQuery.find(t,a);});return = this.pushStack(/[^+>] = [^+>]/.test(t)||t.indexOf("..")>-1?jQuery.unique(data):data);},clone:func= tion(events){var ret=3Dthis.map(function(){return = this.outerHTML?jQuery(this.outerHTML)[0]:this.cloneNode(true);});var = clone=3Dret.find("*").andSelf().each(function(){if(this[expando]!=3Dundef= ined)this[expando]=3Dnull;});if(events=3D=3D=3Dtrue)this.find("*").andSel= f().each(function(i){var events=3DjQuery.data(this,"events");for(var = type in events)for(var handler in = events[type])jQuery.event.add(clone[i],type,events[type][handler],events[= type][handler].data);});return ret;},filter:function(t){return = this.pushStack(jQuery.isFunction(t)&&jQuery.grep(this,function(el,index){= return = t.apply(el,[index]);})||jQuery.multiFilter(t,this));},not:function(t){ret= urn = this.pushStack(t.constructor=3D=3DString&&jQuery.multiFilter(t,this,true)= ||jQuery.grep(this,function(a){return(t.constructor=3D=3DArray||t.jquery)= ?jQuery.inArray(a,t)<0:a!=3Dt;}));},add:function(t){return = this.pushStack(jQuery.merge(this.get(),t.constructor=3D=3DString?jQuery(t= ).get():t.length!=3Dundefined&&(!t.nodeName||jQuery.nodeName(t,"form"))?t= :[t]));},is:function(expr){return = expr?jQuery.multiFilter(expr,this).length>0:false;},hasClass:function(exp= r){return = this.is("."+expr);},val:function(val){if(val=3D=3Dundefined){if(this.leng= th){var elem=3Dthis[0];if(jQuery.nodeName(elem,"select")){var = index=3Delem.selectedIndex,a=3D[],options=3Delem.options,one=3Delem.type=3D= =3D"select-one";if(index<0)return null;for(var = i=3Done?index:0,max=3Done?index+1:options.length;i=3D0||jQuery.i= nArray(this.name,val)>=3D0);else if(jQuery.nodeName(this,"select")){var = tmp=3Dval.constructor=3D=3DArray?val:[val];jQuery("option",this).each(fun= ction(){this.selected=3D(jQuery.inArray(this.value,tmp)>=3D0||jQuery.inAr= ray(this.text,tmp)>=3D0);});if(!tmp.length)this.selectedIndex=3D-1;}else=0A= this.value=3Dval;});},html:function(val){return = val=3D=3Dundefined?(this.length?this[0].innerHTML:null):this.empty().appe= nd(val);},replaceWith:function(val){return = this.after(val).remove();},eq:function(i){return = this.slice(i,i+1);},slice:function(){return = this.pushStack(Array.prototype.slice.apply(this,arguments));},map:functio= n(fn){return this.pushStack(jQuery.map(this,function(elem,i){return = fn.call(elem,i,elem);}));},andSelf:function(){return = this.add(this.prevObject);},domManip:function(args,table,dir,fn){var = clone=3Dthis.length>1,a;return = this.each(function(){if(!a){a=3DjQuery.clean(args,this.ownerDocument);if(= dir<0)a.reverse();}var = obj=3Dthis;if(table&&jQuery.nodeName(this,"table")&&jQuery.nodeName(a[0],= "tr"))obj=3Dthis.getElementsByTagName("tbody")[0]||this.appendChild(docum= ent.createElement("tbody"));jQuery.each(a,function(){var = elem=3Dclone?this.cloneNode(true):this;if(!evalScript(0,elem))fn.call(obj= ,elem);});});}};function evalScript(i,elem){var = script=3DjQuery.nodeName(elem,"script");if(script){if(elem.src)jQuery.aja= x({url:elem.src,async:false,dataType:"script"});else=0A= jQuery.globalEval(elem.text||elem.textContent||elem.innerHTML||"");if(ele= m.parentNode)elem.parentNode.removeChild(elem);}else = if(elem.nodeType=3D=3D1)jQuery("script",elem).each(evalScript);return = script;}jQuery.extend=3DjQuery.fn.extend=3Dfunction(){var = target=3Darguments[0]||{},a=3D1,al=3Darguments.length,deep=3Dfalse;if(tar= get.constructor=3D=3DBoolean){deep=3Dtarget;target=3Darguments[1]||{};}if= (al=3D=3D1){target=3Dthis;a=3D0;}var = prop;for(;a-1;}},swap:fun= ction(e,o,f){for(var i in = o){e.style["old"+i]=3De.style[i];e.style[i]=3Do[i];}f.apply(e,[]);for(var= i in = o)e.style[i]=3De.style["old"+i];},css:function(e,p){if(p=3D=3D"height"||p= =3D=3D"width"){var = old=3D{},oHeight,oWidth,d=3D["Top","Bottom","Right","Left"];jQuery.each(d= ,function(){old["padding"+this]=3D0;old["border"+this+"Width"]=3D0;});jQu= ery.swap(e,old,function(){if(jQuery(e).is(':visible')){oHeight=3De.offset= Height;oWidth=3De.offsetWidth;}else{e=3DjQuery(e.cloneNode(true)).find(":= radio").removeAttr("checked").end().css({visibility:"hidden",position:"ab= solute",display:"block",right:"0",left:"0"}).appendTo(e.parentNode)[0];va= r = parPos=3DjQuery.css(e.parentNode,"position")||"static";if(parPos=3D=3D"st= atic")e.parentNode.style.position=3D"relative";oHeight=3De.clientHeight;o= Width=3De.clientWidth;if(parPos=3D=3D"static")e.parentNode.style.position= =3D"static";e.parentNode.removeChild(e);}});return = p=3D=3D"height"?oHeight:oWidth;}return = jQuery.curCSS(e,p);},curCSS:function(elem,prop,force){var = ret,stack=3D[],swap=3D[];function = color(a){if(!jQuery.browser.safari)return false;var = ret=3Ddocument.defaultView.getComputedStyle(a,null);return!ret||ret.getPr= opertyValue("color")=3D=3D"";}if(prop=3D=3D"opacity"&&jQuery.browser.msie= ){ret=3DjQuery.attr(elem.style,"opacity");return = ret=3D=3D""?"1":ret;}if(prop.match(/float/i))prop=3DstyleFloat;if(!force&= &elem.style[prop])ret=3Delem.style[prop];else = if(document.defaultView&&document.defaultView.getComputedStyle){if(prop.m= atch(/float/i))prop=3D"float";prop=3Dprop.replace(/([A-Z])/g,"-$1").toLow= erCase();var = cur=3Ddocument.defaultView.getComputedStyle(elem,null);if(cur&&!color(ele= m))ret=3Dcur.getPropertyValue(prop);else{for(var = a=3Delem;a&&color(a);a=3Da.parentNode)stack.unshift(a);for(a=3D0;a]*?)\/>/g,function(m,all,= tag){return = tag.match(/^(abbr|br|col|img|input|link|meta|param|hr|area)$/i)?m:all+"><= /"+tag+">";});var = s=3DjQuery.trim(arg).toLowerCase(),div=3Ddoc.createElement("div"),tb=3D[]= ;var = wrap=3D!s.indexOf("",""]||!s.indexOf("",""]||s.match(/^<(thead|tbody|tfoot|colg|cap)= /)&&[1,"","
"]||!s.indexOf("",""]||(!s.indexOf("",""]||!s.indexOf("<= /tbody>",""]||jQuery.browser.msie&&[1,"div","
"]||[0,"",""];div.innerHTML=3Dwrap[1]+arg+wrap[2];while(wrap[= 0]--)div=3Ddiv.lastChild;if(jQuery.browser.msie){if(!s.indexOf(""&&s.indexOf("=3D0;--n)if(jQuery.nodeName(tb[n],"tbody")&&!tb[n].chil= dNodes.length)tb[n].parentNode.removeChild(tb[n]);if(/^\s/.test(arg))div.= insertBefore(doc.createTextNode(arg.match(/^\s*/)[0]),div.firstChild);}ar= g=3DjQuery.makeArray(div.childNodes);}if(0=3D=3D=3Darg.length&&(!jQuery.n= odeName(arg,"form")&&!jQuery.nodeName(arg,"select")))return;if(arg[0]=3D=3D= undefined||jQuery.nodeName(arg,"form")||arg.options)r.push(arg);else=0A= r=3DjQuery.merge(r,arg);});return r;},attr:function(elem,name,value){var = fix=3DjQuery.isXMLDoc(elem)?{}:jQuery.props;if(name=3D=3D"selected"&&jQue= ry.browser.safari)elem.parentNode.selectedIndex;if(fix[name]){if(value!=3D= undefined)elem[fix[name]]=3Dvalue;return elem[fix[name]];}else = if(jQuery.browser.msie&&name=3D=3D"style")return = jQuery.attr(elem.style,"cssText",value);else = if(value=3D=3Dundefined&&jQuery.browser.msie&&jQuery.nodeName(elem,"form"= )&&(name=3D=3D"action"||name=3D=3D"method"))return = elem.getAttributeNode(name).nodeValue;else = if(elem.tagName){if(value!=3Dundefined){if(name=3D=3D"type"&&jQuery.nodeN= ame(elem,"input")&&elem.parentNode)throw"type property can't be = changed";elem.setAttribute(name,value);}if(jQuery.browser.msie&&/href|src= /.test(name)&&!jQuery.isXMLDoc(elem))return = elem.getAttribute(name,2);return = elem.getAttribute(name);}else{if(name=3D=3D"opacity"&&jQuery.browser.msie= ){if(value!=3Dundefined){elem.zoom=3D1;elem.filter=3D(elem.filter||"").re= place(/alpha\([^)]*\)/,"")+(parseFloat(value).toString()=3D=3D"NaN"?"":"a= lpha(opacity=3D"+value*100+")");}return = elem.filter?(parseFloat(elem.filter.match(/opacity=3D([^)]*)/)[1])/100).t= oString():"";}name=3Dname.replace(/-([a-z])/ig,function(z,b){return = b.toUpperCase();});if(value!=3Dundefined)elem[name]=3Dvalue;return = elem[name];}},trim:function(t){return(t||"").replace(/^\s+|\s+$/g,"");},m= akeArray:function(a){var r=3D[];if(typeof a!=3D"array")for(var = i=3D0,al=3Da.length;i\\s*("+chars+"+)"),quickID=3Dnew = RegExp("^("+chars+"+)(#)("+chars+"+)"),quickClass=3Dnew = RegExp("^([#.]?)("+chars+"*)");jQuery.extend({expr:{"":"m[2]=3D=3D'*'||jQ= uery.nodeName(a,m[2])","#":"a.getAttribute('id')=3D=3Dm[2]",":":{lt:"im[3]-0",nth:"m[3]-0=3D=3Di",eq:"m[3]-0=3D=3Di",first:"i=3D=3D= 0",last:"i=3D=3Dr.length-1",even:"i%2=3D=3D0",odd:"i%2","first-child":"a.= parentNode.getElementsByTagName('*')[0]=3D=3Da","last-child":"jQuery.nth(= a.parentNode.lastChild,1,'previousSibling')=3D=3Da","only-child":"!jQuery= .nth(a.parentNode.lastChild,2,'previousSibling')",parent:"a.firstChild",e= mpty:"!a.firstChild",contains:"(a.textContent||a.innerText||jQuery(a).tex= t()||'').indexOf(m[3])>=3D0",visible:'"hidden"!=3Da.type&&jQuery.css(a,"d= isplay")!=3D"none"&&jQuery.css(a,"visibility")!=3D"hidden"',hidden:'"hidd= en"=3D=3Da.type||jQuery.css(a,"display")=3D=3D"none"||jQuery.css(a,"visib= ility")=3D=3D"hidden"',enabled:"!a.disabled",disabled:"a.disabled",checke= d:"a.checked",selected:"a.selected||jQuery.attr(a,'selected')",text:"'tex= t'=3D=3Da.type",radio:"'radio'=3D=3Da.type",checkbox:"'checkbox'=3D=3Da.t= ype",file:"'file'=3D=3Da.type",password:"'password'=3D=3Da.type",submit:"= 'submit'=3D=3Da.type",image:"'image'=3D=3Da.type",reset:"'reset'=3D=3Da.t= ype",button:'"button"=3D=3Da.type||jQuery.nodeName(a,"button")',input:"/i= nput|select|textarea|button/i.test(a.nodeName)",has:"jQuery.find(m[3],a).= length",header:"/h\\d/i.test(a.nodeName)",animated:"jQuery.grep(jQuery.ti= mers,function(fn){return a=3D=3Dfn.elem;}).length"}},parse:[/^(\[) = *@?([\w-]+) *([!*$^~=3D]*) *('?"?)(.*?)\4 = *\]/,/^(:)([\w-]+)\("?'?(.*?(\(.*?\))?[^(]*?)"?'?\)/,new = RegExp("^([:.#]*)("+chars+"+)")],multiFilter:function(expr,elems,not){var= old,cur=3D[];while(expr&&expr!=3Dold){old=3Dexpr;var = f=3DjQuery.filter(expr,elems,not);expr=3Df.t.replace(/^\s*,\s*/,"");cur=3D= not?elems=3Df.r:jQuery.merge(cur,f.r);}return = cur;},find:function(t,context){if(typeof = t!=3D"string")return[t];if(context&&!context.nodeType)context=3Dnull;cont= ext=3Dcontext||document;var = ret=3D[context],done=3D[],last;while(t&&last!=3Dt){var = r=3D[];last=3Dt;t=3DjQuery.trim(t);var foundToken=3Dfalse;var = re=3DquickChild;var m=3Dre.exec(t);if(m){var = nodeName=3Dm[1].toUpperCase();for(var i=3D0;ret[i];i++)for(var = c=3Dret[i].firstChild;c;c=3Dc.nextSibling)if(c.nodeType=3D=3D1&&(nodeName= =3D=3D"*"||c.nodeName.toUpperCase()=3D=3DnodeName.toUpperCase()))r.push(c= );ret=3Dr;t=3Dt.replace(re,"");if(t.indexOf(" = ")=3D=3D0)continue;foundToken=3Dtrue;}else{re=3D/^([>+~])\s*(\w*)/i;if((m= =3Dre.exec(t))!=3Dnull){r=3D[];var = nodeName=3Dm[2],merge=3D{};m=3Dm[1];for(var = j=3D0,rl=3Dret.length;j=3D0)^not)tmp.= push(a);}r=3Dtmp;}else if(m[1]=3D=3D":"&&m[2]=3D=3D"nth-child"){var = merge=3D{},tmp=3D[],test=3D/(\d*)n\+?(\d*)/.exec(m[3]=3D=3D"even"&&"2n"||= m[3]=3D=3D"odd"&&"2n+1"||!/\D/.test(m[3])&&"n+"+m[3]||m[3]),first=3D(test= [1]||1)-0,last=3Dtest[2]-0;for(var i=3D0,rl=3Dr.length;i<\/script>");var = script=3Ddocument.getElementById("__ie_init");if(script)script.onreadysta= techange=3Dfunction(){if(this.readyState!=3D"complete")return;jQuery.read= y();};script=3Dnull;}else = if(jQuery.browser.safari)jQuery.safariTimer=3DsetInterval(function(){if(d= ocument.readyState=3D=3D"loaded"||document.readyState=3D=3D"complete"){cl= earInterval(jQuery.safariTimer);jQuery.safariTimer=3Dnull;jQuery.ready();= }},10);jQuery.event.add(window,"load",jQuery.ready);}jQuery.fn.extend({lo= ad:function(url,params,callback){if(jQuery.isFunction(url))return = this.bind("load",url);var off=3Durl.indexOf(" ");if(off>=3D0){var = selector=3Durl.slice(off,url.length);url=3Durl.slice(0,off);}callback=3Dc= allback||function(){};var = type=3D"GET";if(params)if(jQuery.isFunction(params)){callback=3Dparams;pa= rams=3Dnull;}else{params=3DjQuery.param(params);type=3D"POST";}var = self=3Dthis;jQuery.ajax({url:url,type:type,data:params,complete:function(= res,status){if(status=3D=3D"success"||status=3D=3D"notmodified")self.html= (selector?jQuery("
").append(res.responseText.replace(//g,"")).find(selector):res.responseText);setTimeout(function()= {self.each(callback,[res.responseText,status,res]);},13);}});return = this;},serialize:function(){return = jQuery.param(this.serializeArray());},serializeArray:function(){return = this.map(function(){return = jQuery.nodeName(this,"form")?jQuery.makeArray(this.elements):this;}).filt= er(function(){return = this.name&&!this.disabled&&(this.checked||/select|textarea/i.test(this.no= deName)||/text|hidden|password/i.test(this.type));}).map(function(i,elem)= {var val=3DjQuery(this).val();return = val=3D=3Dnull?null:val.constructor=3D=3DArray?jQuery.map(val,function(val= ,i){return{name:elem.name,value:val};}):{name:elem.name,value:val};}).get= ();}});jQuery.each("ajaxStart,ajaxStop,ajaxComplete,ajaxError,ajaxSuccess= ,ajaxSend".split(","),function(i,o){jQuery.fn[o]=3Dfunction(f){return = this.bind(o,f);};});var jsc=3D(new = Date).getTime();jQuery.extend({get:function(url,data,callback,type){if(jQ= uery.isFunction(data)){callback=3Ddata;data=3Dnull;}return = jQuery.ajax({type:"GET",url:url,data:data,success:callback,dataType:type}= );},getScript:function(url,callback){return = jQuery.get(url,null,callback,"script");},getJSON:function(url,data,callba= ck){return = jQuery.get(url,data,callback,"json");},post:function(url,data,callback,ty= pe){if(jQuery.isFunction(data)){callback=3Ddata;data=3D{};}return = jQuery.ajax({type:"POST",url:url,data:data,success:callback,dataType:type= });},ajaxSetup:function(settings){jQuery.extend(jQuery.ajaxSettings,setti= ngs);},ajaxSettings:{global:true,type:"GET",timeout:0,contentType:"applic= ation/x-www-form-urlencoded",processData:true,async:true,data:null},lastM= odified:{},ajax:function(s){var = jsonp,jsre=3D/=3D(\?|%3F)/g,status,data;s=3DjQuery.extend(true,s,jQuery.e= xtend(true,{},jQuery.ajaxSettings,s));if(s.data&&s.processData&&typeof = s.data!=3D"string")s.data=3DjQuery.param(s.data);if(s.dataType=3D=3D"json= p"){if(s.type.toLowerCase()=3D=3D"get"){if(!s.url.match(jsre))s.url+=3D(s= .url.match(/\?/)?"&":"?")+(s.jsonp||"callback")+"=3D?";}else = if(!s.data||!s.data.match(jsre))s.data=3D(s.data?s.data+"&":"")+(s.jsonp|= |"callback")+"=3D?";s.dataType=3D"json";}if(s.dataType=3D=3D"json"&&(s.da= ta&&s.data.match(jsre)||s.url.match(jsre))){jsonp=3D"jsonp"+jsc++;if(s.da= ta)s.data=3Ds.data.replace(jsre,"=3D"+jsonp);s.url=3Ds.url.replace(jsre,"= =3D"+jsonp);s.dataType=3D"script";window[jsonp]=3Dfunction(tmp){data=3Dtm= p;success();complete();window[jsonp]=3Dundefined;try{delete = window[jsonp];}catch(e){}};}if(s.dataType=3D=3D"script"&&s.cache=3D=3Dnul= l)s.cache=3Dfalse;if(s.cache=3D=3D=3Dfalse&&s.type.toLowerCase()=3D=3D"ge= t")s.url+=3D(s.url.match(/\?/)?"&":"?")+"_=3D"+(new = Date()).getTime();if(s.data&&s.type.toLowerCase()=3D=3D"get"){s.url+=3D(s= .url.match(/\?/)?"&":"?")+s.data;s.data=3Dnull;}if(s.global&&!jQuery.acti= ve++)jQuery.event.trigger("ajaxStart");if(!s.url.indexOf("http")&&s.dataT= ype=3D=3D"script"){var = head=3Ddocument.getElementsByTagName("head")[0];var = script=3Ddocument.createElement("script");script.src=3Ds.url;if(!jsonp&&(= s.success||s.complete)){var = done=3Dfalse;script.onload=3Dscript.onreadystatechange=3Dfunction(){if(!d= one&&(!this.readyState||this.readyState=3D=3D"loaded"||this.readyState=3D= =3D"complete")){done=3Dtrue;success();complete();head.removeChild(script)= ;}};}head.appendChild(script);return;}var requestDone=3Dfalse;var = xml=3Dwindow.ActiveXObject?new ActiveXObject("Microsoft.XMLHTTP"):new = XMLHttpRequest();xml.open(s.type,s.url,s.async);if(s.data)xml.setRequestH= eader("Content-Type",s.contentType);if(s.ifModified)xml.setRequestHeader(= "If-Modified-Since",jQuery.lastModified[s.url]||"Thu, 01 Jan 1970 = 00:00:00 = GMT");xml.setRequestHeader("X-Requested-With","XMLHttpRequest");if(s.befo= reSend)s.beforeSend(xml);if(s.global)jQuery.event.trigger("ajaxSend",[xml= ,s]);var = onreadystatechange=3Dfunction(isTimeout){if(!requestDone&&xml&&(xml.ready= State=3D=3D4||isTimeout=3D=3D"timeout")){requestDone=3Dtrue;if(ival){clea= rInterval(ival);ival=3Dnull;}status=3DisTimeout=3D=3D"timeout"&&"timeout"= ||!jQuery.httpSuccess(xml)&&"error"||s.ifModified&&jQuery.httpNotModified= (xml,s.url)&&"notmodified"||"success";if(status=3D=3D"success"){try{data=3D= jQuery.httpData(xml,s.dataType);}catch(e){status=3D"parsererror";}}if(sta= tus=3D=3D"success"){var = modRes;try{modRes=3Dxml.getResponseHeader("Last-Modified");}catch(e){}if(= s.ifModified&&modRes)jQuery.lastModified[s.url]=3DmodRes;if(!jsonp)succes= s();}else=0A= jQuery.handleError(s,xml,status);complete();if(s.async)xml=3Dnull;}};if(s= .async){var = ival=3DsetInterval(onreadystatechange,13);if(s.timeout>0)setTimeout(funct= ion(){if(xml){xml.abort();if(!requestDone)onreadystatechange("timeout");}= },s.timeout);}try{xml.send(s.data);}catch(e){jQuery.handleError(s,xml,nul= l,e);}if(!s.async)onreadystatechange();return xml;function = success(){if(s.success)s.success(data,status);if(s.global)jQuery.event.tr= igger("ajaxSuccess",[xml,s]);}function = complete(){if(s.complete)s.complete(xml,status);if(s.global)jQuery.event.= trigger("ajaxComplete",[xml,s]);if(s.global&&!--jQuery.active)jQuery.even= t.trigger("ajaxStop");}},handleError:function(s,xml,status,e){if(s.error)= s.error(xml,status,e);if(s.global)jQuery.event.trigger("ajaxError",[xml,s= ,e]);},active:0,httpSuccess:function(r){try{return!r.status&&location.pro= tocol=3D=3D"file:"||(r.status>=3D200&&r.status<300)||r.status=3D=3D304||j= Query.browser.safari&&r.status=3D=3Dundefined;}catch(e){}return = false;},httpNotModified:function(xml,url){try{var = xmlRes=3Dxml.getResponseHeader("Last-Modified");return = xml.status=3D=3D304||xmlRes=3D=3DjQuery.lastModified[url]||jQuery.browser= .safari&&xml.status=3D=3Dundefined;}catch(e){}return = false;},httpData:function(r,type){var = ct=3Dr.getResponseHeader("content-type");var = xml=3Dtype=3D=3D"xml"||!type&&ct&&ct.indexOf("xml")>=3D0;var = data=3Dxml?r.responseXML:r.responseText;if(xml&&data.documentElement.tagN= ame=3D=3D"parsererror")throw"parsererror";if(type=3D=3D"script")jQuery.gl= obalEval(data);if(type=3D=3D"json")data=3Deval("("+data+")");return = data;},param:function(a){var = s=3D[];if(a.constructor=3D=3DArray||a.jquery)jQuery.each(a,function(){s.p= ush(encodeURIComponent(this.name)+"=3D"+encodeURIComponent(this.value));}= );else=0A= for(var j in = a)if(a[j]&&a[j].constructor=3D=3DArray)jQuery.each(a[j],function(){s.push= (encodeURIComponent(j)+"=3D"+encodeURIComponent(this));});else=0A= s.push(encodeURIComponent(j)+"=3D"+encodeURIComponent(a[j]));return = s.join("&").replace(/%20/g,"+");}});jQuery.fn.extend({show:function(speed= ,callback){return = speed?this.animate({height:"show",width:"show",opacity:"show"},speed,call= back):this.filter(":hidden").each(function(){this.style.display=3Dthis.ol= dblock?this.oldblock:"";if(jQuery.css(this,"display")=3D=3D"none")this.st= yle.display=3D"block";}).end();},hide:function(speed,callback){return = speed?this.animate({height:"hide",width:"hide",opacity:"hide"},speed,call= back):this.filter(":visible").each(function(){this.oldblock=3Dthis.oldblo= ck||jQuery.css(this,"display");if(this.oldblock=3D=3D"none")this.oldblock= =3D"block";this.style.display=3D"none";}).end();},_toggle:jQuery.fn.toggl= e,toggle:function(fn,fn2){return = jQuery.isFunction(fn)&&jQuery.isFunction(fn2)?this._toggle(fn,fn2):fn?thi= s.animate({height:"toggle",width:"toggle",opacity:"toggle"},fn,fn2):this.= each(function(){jQuery(this)[jQuery(this).is(":hidden")?"show":"hide"]();= });},slideDown:function(speed,callback){return = this.animate({height:"show"},speed,callback);},slideUp:function(speed,cal= lback){return = this.animate({height:"hide"},speed,callback);},slideToggle:function(speed= ,callback){return = this.animate({height:"toggle"},speed,callback);},fadeIn:function(speed,ca= llback){return = this.animate({opacity:"show"},speed,callback);},fadeOut:function(speed,ca= llback){return = this.animate({opacity:"hide"},speed,callback);},fadeTo:function(speed,to,= callback){return = this.animate({opacity:to},speed,callback);},animate:function(prop,speed,e= asing,callback){var opt=3DjQuery.speed(speed,easing,callback);return = this[opt.queue=3D=3D=3Dfalse?"each":"queue"](function(){opt=3DjQuery.exte= nd({},opt);var hidden=3DjQuery(this).is(":hidden"),self=3Dthis;for(var p = in = prop){if(prop[p]=3D=3D"hide"&&hidden||prop[p]=3D=3D"show"&&!hidden)return= = jQuery.isFunction(opt.complete)&&opt.complete.apply(this);if(p=3D=3D"heig= ht"||p=3D=3D"width"){opt.display=3DjQuery.css(this,"display");opt.overflo= w=3Dthis.style.overflow;}}if(opt.overflow!=3Dnull)this.style.overflow=3D"= hidden";opt.curAnim=3DjQuery.extend({},prop);jQuery.each(prop,function(na= me,val){var e=3Dnew = jQuery.fx(self,opt,name);if(/toggle|show|hide/.test(val))e[val=3D=3D"togg= le"?hidden?"show":"hide":val](prop);else{var = parts=3Dval.toString().match(/^([+-]=3D)?([\d+-.]+)(.*)$/),start=3De.cur(= true)||0;if(parts){var = end=3DparseFloat(parts[2]),unit=3Dparts[3]||"px";if(unit!=3D"px"){self.st= yle[name]=3D(end||1)+unit;start=3D((end||1)/e.cur(true))*start;self.style= [name]=3Dstart+unit;}if(parts[1])end=3D((parts[1]=3D=3D"-=3D"?-1:1)*end)+= start;e.custom(start,end,unit);}else=0A= e.custom(start,val,"");}});return = true;});},queue:function(type,fn){if(jQuery.isFunction(type)){fn=3Dtype;t= ype=3D"fx";}if(!type||(typeof type=3D=3D"string"&&!fn))return = queue(this[0],type);return = this.each(function(){if(fn.constructor=3D=3DArray)queue(this,type,fn);els= e{queue(this,type).push(fn);if(queue(this,type).length=3D=3D1)fn.apply(th= is);}});},stop:function(){var timers=3DjQuery.timers;return = this.each(function(){for(var = i=3D0;i-10000?r:parseFloat(jQuery.css(this.elem,this.prop))||0;},custom:fun= ction(from,to,unit){this.startTime=3D(new = Date()).getTime();this.start=3Dfrom;this.end=3Dto;this.unit=3Dunit||this.= unit||"px";this.now=3Dthis.start;this.pos=3Dthis.state=3D0;this.update();= var self=3Dthis;function t(){return = self.step();}t.elem=3Dthis.elem;jQuery.timers.push(t);if(jQuery.timers.le= ngth=3D=3D1){var timer=3DsetInterval(function(){var = timers=3DjQuery.timers;for(var = i=3D0;ithis.options.duration+this.startTime){this.now=3Dt= his.end;this.pos=3Dthis.state=3D1;this.update();this.options.curAnim[this= .prop]=3Dtrue;var done=3Dtrue;for(var i in = this.options.curAnim)if(this.options.curAnim[i]!=3D=3Dtrue)done=3Dfalse;i= f(done){if(this.options.display!=3Dnull){this.elem.style.overflow=3Dthis.= options.overflow;this.elem.style.display=3Dthis.options.display;if(jQuery= .css(this.elem,"display")=3D=3D"none")this.elem.style.display=3D"block";}= if(this.options.hide)this.elem.style.display=3D"none";if(this.options.hid= e||this.options.show)for(var p in = this.options.curAnim)jQuery.attr(this.elem.style,p,this.options.orig[p]);= }if(done&&jQuery.isFunction(this.options.complete))this.options.complete.= apply(this.elem);return false;}else{var = n=3Dt-this.startTime;this.state=3Dn/this.options.duration;this.pos=3DjQue= ry.easing[this.options.easing||(jQuery.easing.swing?"swing":"linear")](th= is.state,n,0,1,this.options.duration);this.now=3Dthis.start+((this.end-th= is.start)*this.pos);this.update();}return = true;}};jQuery.fx.step=3D{scrollLeft:function(fx){fx.elem.scrollLeft=3Dfx= .now;},scrollTop:function(fx){fx.elem.scrollTop=3Dfx.now;},opacity:functi= on(fx){jQuery.attr(fx.elem.style,"opacity",fx.now);},_default:function(fx= ){fx.elem.style[fx.prop]=3Dfx.now+fx.unit;}};jQuery.fn.offset=3Dfunction(= ){var = left=3D0,top=3D0,elem=3Dthis[0],results;if(elem)with(jQuery.browser){var = absolute=3DjQuery.css(elem,"position")=3D=3D"absolute",parent=3Delem.pare= ntNode,offsetParent=3Delem.offsetParent,doc=3Delem.ownerDocument,safari2=3D= safari&&parseInt(version)<522;if(elem.getBoundingClientRect){box=3Delem.g= etBoundingClientRect();add(box.left+Math.max(doc.documentElement.scrollLe= ft,doc.body.scrollLeft),box.top+Math.max(doc.documentElement.scrollTop,do= c.body.scrollTop));if(msie){var = border=3DjQuery("html").css("borderWidth");border=3D(border=3D=3D"medium"= ||jQuery.boxModel&&parseInt(version)>=3D7)&&2||border;add(-border,-border= );}}else{add(elem.offsetLeft,elem.offsetTop);while(offsetParent){add(offs= etParent.offsetLeft,offsetParent.offsetTop);if(mozilla&&/^t[d|h]$/i.test(= parent.tagName)||!safari2)border(offsetParent);if(safari2&&!absolute&&jQu= ery.css(offsetParent,"position")=3D=3D"absolute")absolute=3Dtrue;offsetPa= rent=3DoffsetParent.offsetParent;}while(parent.tagName&&!/^body|html$/i.t= est(parent.tagName)){if(!/^inline|table-row.*$/i.test(jQuery.css(parent,"= display")))add(-parent.scrollLeft,-parent.scrollTop);if(mozilla&&jQuery.c= ss(parent,"overflow")!=3D"visible")border(parent);parent=3Dparent.parentN= ode;}if(safari2&&absolute)add(-doc.body.offsetLeft,-doc.body.offsetTop);}= results=3D{top:top,left:left};}return results;function = border(elem){add(jQuery.css(elem,"borderLeftWidth"),jQuery.css(elem,"bord= erTopWidth"));}function = add(l,t){left+=3DparseInt(l)||0;top+=3DparseInt(t)||0;}};})(); ------=_NextPart_000_0000_01C8B513.C8FF74D0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/common/scripts/global.js (function($) { $(document).ready(function () { // enables dropdown ads to display whilst maintaining .user-services = visibility aat small resolutions // yes, it involves browser detection, and yes, that is truly = horrible. if (jQuery.browser.mozilla) { =09 var dropdownAd =3D false; =09 // for each descendant of .leaderboard that isn't a