From: Subject: Primary Glioblastomas Express Mesenchymal Stem-Like Properties -- Tso et al. 4 (9): 607 -- Molecular Cancer Research Date: Mon, 4 Aug 2008 15:25:09 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_00DF_01C8F646.47BE8130" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_00DF_01C8F646.47BE8130 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://mcr.aacrjournals.org/cgi/content/full/4/9/607 Primary Glioblastomas Express Mesenchymal Stem-Like = Properties -- Tso et al. 4 (9): 607 -- Molecular Cancer Research 3D"Molecular=20 3D"
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Molecular Cancer Research 4:607-619 (2006)
=A9 = 2006 American = Association for=20 Cancer Research

Cancer Genes and Genomics

Primary Glioblastomas Express Mesenchymal Stem-Like Properties=20

Cho-Lea=20 Tso1,2,6, Peter=20 Shintaku3,6, James = Chen1,=20 Qinghai Liu2, Jason = Liu1,=20 Zugen Chen1, Koji = Yoshimoto3,=20 Paul S. Mischel3,6, Timothy F.=20 Cloughesy4,6, Linda M.=20 Liau5,6 and Stanley F.=20 Nelson1,6

Departments of 1 Human Genetics, = 2=20 Medicine/Hematology-Oncology, 3 Pathology and Laboratory = Medicine,=20 4 Neurology, and 5 Neurosurgery, David Geffen = School of=20 Medicine and 6 Jonsson Comprehensive Cancer Center, = University of=20 California Los Angeles, Los Angeles, California

Requests for reprints: Stanley F. = Nelson,=20 Department of Human Genetics, David Geffen School of Medicine, = University of=20 California at Los Angeles, Room 5506, 695 Young Drive South, Los = Angeles, CA=20 90095. Phone: 310-794-7981. E-mail: snelson{at}ucla.edu


3D"   =20 Abstract
Top
Notes
3D"Abstract
Introduction
Results
Discussion
Materials and Methods
Acknowledgements
References
 
G= lioblastoma=20 is the most common and aggressive primary brain cancer. = Recent=20 isolation and characterization of brain tumor-initiating = cells=20 supports the concept that transformed neural stem cells may = seed=20 glioblastoma. We previously identified a wide array of = mesenchymal=20 tissue transcripts overexpressed in a broad set of primary=20 glioblastoma (de novo) tumors but not in secondary=20 glioblastoma (derived from lower-grade) tumors, low-grade=20 astrocytomas, or normal brain tissues. Here, we extend this=20 observation and show that a subset of primary glioblastoma = tumors and=20 their derived tumor lines express cellular and molecular = markers=20 that are associated with mesenchymal stem cells (MSC) and = that=20 glioblastoma cell cultures can be induced to differentiate = into=20 multiple mesenchymal lineage-like cell types. These findings=20 suggest either that a subset of primary glioblastomas derive = from=20 transformed stem cells containing MSC-like properties and = retain=20 partial phenotypic aspects of a MSC nature in tumors or that=20 glioblastomas activate a series of genes that result in = mesenchymal=20 properties of the cancer cells to effect sustained tumor = growth and=20 malignant progression. (Mol Cancer Res = 2006;4(9):607=9619)


3D"   =20 Introduction
Top
Notes
Abstract
3D"Introduction
Results
Discussion
Materials and Methods
Acknowledgements
References
 
G= lioblastoma=20 (WHO, grade IV) is the most common and aggressive form of = adult brain=20 tumor (1)= and can=20 derive either de novo with no prior evidence of a = lower-grade=20 tumor, called primary glioblastoma, or through malignant = progression=20 from a lower-grade malignancy, called secondary glioblastoma. = Genetic=20 studies suggest that primary and secondary glioblastomas are = two=20 distinct clinical entities, each developing along distinct = genetic=20 pathways with characteristic genomic losses. Whereas = secondary=20 glioblastomas clearly develop slowly from within lower-grade=20 astrocytoma and frequently contain mutations in the = p53 gene=20 (3D~60%),=20 primary glioblastomas develop rapidly and in general are = thought=20 to arise from astrocytic precursors and are genetically=20 characterized by amplification and/or overexpression of = epidermal=20 growth factor receptor (EGFR; 3D~=2060%; refs. = 1-= 3)= . The=20 cell of origin of glioblastomas has been recently considered = to be of=20 the neural stem cell (NSC) lineage and this concept is = supported by=20 the recent experimental data generated from multiple = laboratories=20 showing that only CD133+ (a cell surface marker of = normal=20 human NSC) but not CD133=96 cells isolated from = glioblastoma=20 tumors contain tumor-initiating cells (4-= 7)= .=20 Additionally, these cells are multipotent in culture and can = be=20 induced to differentiate into neuronal, astroglial, or=20 oligodendroglial cells. Therefore, glioblastoma may be a NSC = disorder=20 or transformed cells reactivate NSC properties (8,= 9)= . For=20 many years, it has been appreciated that, during in = vitro=20 cultivation, glioblastoma cells can express a variety of=20 heterogeneous markers, including multiple mesenchymal markers, = and=20 were generally thought to be due to mesenchymal drift or = cultures are=20 overgrown by mesenchymal cells from the abnormal vascular=20 proliferations of the original glioma (10, 11).=20 Subsequently, a study showing that permanent glioblastoma = cell lines=20 formed tumors in nude mice failed to sustain evidence of = glial=20 differentiation but exhibited the characteristics of = mesenchymal=20 differentiation both in vitro and in vivo (12).=20 Correspondingly, our recent study using whole genome gene = expression=20 analyses of 85 high-grade glial tumors also identified a = subset of=20 glioblastoma tumors overexpressing transcripts of = extracellular=20 matrix (ECM) components, which correlates with a set of genes = typically expressed in mesenchyme-derived tissues (13).=20 Follow-up studies further identified that a series of=20 mesenchymal-associated transcripts that partially overlapped = with=20 previous study are only overexpressed in a subset of primary=20 glioblastomas but not in secondary glioblastoma, low-grade=20 astrocytoma, or normal brain (14). These=20 observations thus support the possibility of a fundamentally = distinct=20 mechanism of oncogenesis and progression in at least a subset = of=20 primary glioblastomas.

Recent studies suggest that stem cell plasticity is a = characteristic=20 of NSC and that the differentiation of NSC into unanticipated = cell types, including hematopoietic, muscle, and endothelial=20 cells (15-17), has=20 been shown. Likewise, mesenchymal stem cells (MSC), which can = give=20 rise to various cell types of mesenchymal tissues, such as = bone,=20 cartilage, adipose, and muscle (18),=20 could differentiate into astrocytes and neurons (19, 20).=20 A microarray analysis of a single MSC further explored a = panel=20 of lineage-related transcripts associated with osteoblast,=20 fibroblast, muscle, adipocyte, epithelial cells, endothelial = cells,=20 and neural/glial cells (21-25).=20 Recently, transcription profiling has uncovered an = overlapping=20 genetic program in various types of stem cells (26) and=20 therefore supports the concept that somatic stem cells have a = broad=20 differentiation repertoire. In the present study, we show = that=20 primary glioblastoma tumors and their passaged tumor cell = lines=20 express cellular and molecular characteristics of MSC. = Further, when=20 treated with adipogenic, osteogenic, or chondrogenic = induction=20 medium, primary glioblastoma cell lines are capable of=20 differentiating into mesenchymal lineage cell types, thus = implying=20 that a subset of primary glioblastomas may use mesenchymal = properties=20 to attain their malignant phenotype.


3D"   =20 Results
Top
Notes
Abstract
Introduction
3D"Results
Discussion
Materials and Methods
Acknowledgements
References
 
<= EM>Primary=20 Glioblastoma Biopsies Express Mesenchymal and NSC-Associated = Genes
To=20 identify gain-of-function genes associated with acquisition = of=20 malignant features of glioblastoma, we did a large-scale DNA=20 microarray analysis of 101 glial brain tumors (14).=20 Through a series of comparative analyses relative to = lower-grade=20 astrocytomas, we have identified a list of primary=20 glioblastoma-associated genes that are distinct from being = identified=20 in progression from a lower grade (secondary glioblastoma). A = series=20 of genes that are highly expressed in mesenchymal tissues but = not=20 in neural or glial cells were identified, including bone,=20 cartilage, tendon, ligament, fat, and muscle (e.g., = YKL-40, lysyl=20 oxidase, PDPN, collagen type V and VI, biglycan, = mesenchyme=20 homeobox 2, fatty acid=96binding protein, CA3, and = tangelin;=20 ref. 14). To=20 access and capture genes that are potentially associated with = cellular properties and tumorigenesis of primary glioblastoma, = a=20 comparative analysis of primary glioblastoma (n =3D 46) = relative=20 to normal brain tissue (n =3D 10) was done. Probe set = signals=20 on the U133A array that were 3D≥=202.5-fold in = primary=20 glioblastoma versus the normal brain tissue with a pairwise = t=20 test with a P < 0.05 were selected and the top 100 = genes=20 were presented in Table = 1=20 (see Supplementary Table S1 for more detailed description). = As=20 anticipated, genes that were identified previously as primary=20 glioblastoma progression-associated genes reappeared in this=20 gene list, which reflected the status of inflammation, = coagulation,=20 immune/complement responses, angiogenesis, and ECM remodeling = (14),=20 whereas a new series of genes that are associated with MSC, = MSC=20 differentiation, skeletal/cartilage development, morphogenesis,=20 organogenesis, and embryonic neuroepithelial stem cells = (dChip=20 gene information) were identified (Table = 1;=20 refs. 21-25).=20 Particularly, several mesenchyme-specific genes, normally = associated=20 with osteoblasts and osteoblastic differentiation, are highly = expressed, including POSTN (27),=20 TNC (28, 29),=20 SPARC/osteonectin (30),=20 collagen type I/III (31),=20 CTGF (32),=20 ANXA2 (33),=20 IGFBP3/IGFBP5 (34, 35),=20 osteoactivin (GPNMB; ref. 36),=20 CSPG2 (28), and=20 TAZ (WWTR1; ref. 37). The=20 coexpression of TNC, SPARC, collagens, osteoactivin, and ANX2 = suggests the presence of a molecular program of=20 epithelial-mesenchymal transition (EMT), which is frequently = seen in=20 malignant tumor with a highly invasive phenotype (38-40). TAZ=20 was recently identified as a transcriptional modulator of MSC = differentiation that promotes the development of the = osteoblastic=20 component and represses peroxisome proliferator-activated=20 receptor-3D{gamma}=96dependent adipogenesis (37).=20 Moreover, myostatin (GDF8), IGFBP3/IGFBP5, and ID3 also have = been=20 suggested to play a role in the suppression of myogenesis and = adipogenesis (41-45).=20 Simultaneously, several NSC-associated genes were = overexpressed=20 in primary glioblastoma tumors, including NES, SOX2, SOX4, = SOX11,=20 CXCR, and DLL3. The overexpression of NES = transcript=20 reflected the characteristic of neuroepithelial tumor cells.=20 SOX2 is expressed in embryonic neural epithelial stem = cells=20 (46)=20 and is essential to maintain pluripotent, self-renewal, and=20 undifferentiated phenotypes of embryonic stem cells (47).=20 SOX4 and SOX11 play a role in central nervous = system=20 development (48), and=20 SOX4 gene recently was characterized as a component of = the=20 parathyroid hormone signal transduction pathway in = osteoblastic cells=20 and has an important function in bone formation (49). The=20 chemokine receptor CXCR4 has been regarded as a MSC = and NSC=20 receptor that mediates MSC-specific migration to bone marrow = and NSC=20 migration to injury sites in the central nervous system (50, 51).=20 CXCR4-stromal cell-derived factor-1 pathway was suggested to = play an=20 important role in promoting glioma survival, proliferation, = and=20 migration (52, 53).=20 DLL3 has been shown to function as an inhibitor of = Notch=20 signaling that inhibited glial differentiation of mouse = neural=20 progenitors (54). The=20 distinctive gene expression profile in a set of glioblastoma = and=20 normal brain tissue samples was verified previously by a = real-time=20 quantitative reverse transcription-PCR (RT-PCR) analysis (14). This=20 transcription profile of primary glioblastoma is therefore = indicative=20 of NSC- and MSC-like properties in glioblastoma tumors. =


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  		Table 1. Top 100 Primary=20 Glioblastoma-Associated Genes Expressed at Higher Levels = Compared=20 with Normal Brain Tissue =

 = ;
It=20 is possible that the mesenchymal gene expression detected was = reflecting a mixture of normal stromal cells within the = tumor. To=20 assess this possibility, a tissue microarray consisting of = tumor=20 cores and matching normal brain counterparts from 60 primary=20 glioblastomas and 16 secondary glioblastomas was constructed = to allow=20 visualization of cancer cells distinct from the supporting = normal=20 tissue. The detection of YKL-40/cartilage glycoprotein-39=20 (cartilage/chondrocyte-associated gene) overexpressed in = clinically=20 defined primary glioblastoma cells but not in secondary = glioblastoma=20 cells was published previously (14). Here,=20 we have further tested two other MSC-associated markers, TNC=20 (myelosupportive stromal-associated gene) and = SPARC/osteonectin=20 (skeletal development-associated gene), which were identified = previously in glioblastoma tumors. Our results showed that = both=20 markers were overexpressed in the primary glioblastoma = samples, and=20 the incidence as well as expression level were significantly = higher=20 in primary glioblastoma than in secondary glioblastoma and = normal=20 brain (Fig.=20 1 ). Although TNC and osteonectin are expressed in = glioblastoma=20 tumors, our analysis pointed out that TNC and osteonectin are = significantly overexpressed in primary glioblastoma = (mesenchymal=20 phenotype) compared with secondary glioblastoma = (proliferation/cell=20 cycle phenotype). The mesenchymal gene expression was = detected=20 broadly throughout the population of malignant cells and ECM=20 showing cellular atypia.



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  		FIGURE 1. Primary = glioblastoma=20 tumors express mesenchymal phenotype. Representative=20 immunohistochemical staining of TNC and osteonectin in = clinical=20 glioblastoma (GBM) subgroups and normal brain. = Subsets of the=20 images from a tissue array. Each core is 0.06 mm across. = Strong=20 positivity of TNC and osteonectin staining was detected in = two=20 primary glioblastoma. Negative/weak staining was detected in = two=20 secondary glioblastoma and two normal brain cores. The = incidence of=20 the expressions of two markers was significantly higher in = primary=20 glioblastoma compared with secondary glioblastoma and normal = brain=20 tissue, and the average intensity of staining in positive = samples=20 was higher in primary glioblastoma when compared with = secondary=20 glioblastoma and normal brain cores. Staining intensity was = scored=20 on a scale of 0 to 2 as described in Materials and Methods.=20 Magnification, x400. =

 = ;
Primary=20 Glioblastoma Biopsy-Derived Tumor Lines Express Molecular Signatures of=20 MSC
To examine whether MSC and mesenchymal lineage cell=20 type=96associated transcripts detected in primary = glioblastoma biopsies=20 are expressed in glioblastoma-derived cells, four permanent=20 glioblastoma biopsy-derived glioblastoma cell lines (W-98, = D-431,=20 F-502, and S-496) were selected for molecular = characterization. To=20 rule out the possibility that glioblastoma cell lines are = stromal=20 cells derived from angiogenic tumors, we determined the = genomic and=20 molecular identities of cell lines. All four cell lines carry = chromosomal abnormalities commonly detected in glioblastomas = using a=20 high-density single nucleotide polymorphism array analysis = (Fig. = 2A ).=20 Notably, D-431 and F-502 exhibit loss of heterozygosity (LOH) = in=20 chromosome 10 but not in chromosome 17, whereas W-98 and = S-496=20 exhibit LOH in both chromosomes. Additionally, amplification = of=20 chromosome 7 was detected in D-431, F-502, and, lesser = degree, S-496.=20 Frequent LOH for chromosome 10 and gain of chromosome 7 have = been=20 linked to mesenchymal glioblastoma subtype (55, 56). To=20 further verify the glioblastoma origin of tumor lines,=20 immunocytochemical staining of YKL-40 and NES was done. = Homogeneous=20 coexpression of NES and YKL-40 in glioblastoma cells was = shown in all=20 glioblastoma cell lines (Fig. = 2B).=20 Transcripts of YKL-40 and NES were also detected in = glioblastoma cell=20 lines using semiquantitative RT-PCR amplification (Fig. = 2C and=20 D). Notably, glioblastoma cell lines overexpress EGFR, = vascular=20 endothelial growth factor, and insulin-like growth factor-I = receptor=20 as other types of tested human cancer cell lines, yet YKL-40 = was only=20 detected in glioblastoma cell lines among the tested cancer = cell=20 lines, suggesting the mesenchymal origin of glioblastoma (Fig. = 2C).=20 To test whether mesenchymal tissue- and MSC-associated genes=20 identified in glioblastoma tumors (Table = 1)=20 are indeed expressed in glioblastoma cell lines, glioblastoma = cell=20 lines were subjected to RT-PCR analysis. The results = indicated that=20 glioblastoma cell lines simultaneously express a host of = transcripts=20 typically expressed in mature mesenchymal lineage cell types = (Fig. = 2D),=20 including bone (collagen type I, III, and V, CTGF, and = SPARC),=20 cartilage/ligament/tendon (CHI3L1/YKL-40, collagen type IV = and VI,=20 and lysyl oxidase), muscle/adipose (transgelin and CA3),=20 myelosupportive stromal tissue (PBEF1 and TNC), and=20 endothelial/epithelial cells (IL8, MMP9, EGFR, and VEGF).=20 Concurrently, transcripts of undifferentiated NSC, NES, and = vimentin,=20 were also detected in all glioblastoma cell lines. A weak = signal of=20 glial fibrillary acidic protein can only be detected in F-509 = using=20 higher number of PCR cycles (40 cycles; data not shown). = Three of the=20 four glioblastoma cell lines, derived from clinically defined = primary=20 glioblastomas, had similar transcription profiles. Notably, = S-496,=20 derived from a clinically defined secondary glioblastoma, had = lower expression levels of several mesenchymal = tissue-associated=20 genes. U87-MG, a commonly studied glioblastoma cell line, = also=20 exhibited mesenchymal expression characteristics similar to = those of=20 the primary glioblastoma samples, whereas several of the = genes=20 tested for expression were barely detectable in fibroblast = cells=20 or peripheral blood lymphocytes. To verify that glioblastoma=20 subtypes express a differential level of MSC-associated = transcript,=20 a real-time quantitative RT-PCR analysis of YKL-40 = expression=20 was done. A higher expression level of YKL-40 transcript was=20 detected in both primary glioblastoma tumors and cell lines=20 (W-98, D-431, and F-502) compared with secondary glioblastoma = tumors, secondary glioblastoma cell line (S-495), and normal=20 brain tissue. YKL-40 transcript was not detectable in both=20 fibroblasts and peripheral blood lymphocytes.



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  		FIGURE 2. Glioblastoma=20 biopsy-derived glioblastoma cell lines express genomic, = cellular,=20 and molecular properties indicative of mesenchymal = phenotype.=20 A. Genomic abnormalities that are associated with = mesenchymal=20 phenotype of glioblastoma were detected in glioblastoma cell = lines.=20 Whole genomic DNA of glioblastoma cell lines (W-98, D-431, = F-502,=20 and S-496) and the fibroblast cell line were evaluated for = allelic=20 imbalances and chromosomal copy number abnormalities by = using a=20 high-density single nucleotide polymorphism array analysis=20 (Affymetrix XbaI 131 Array). X axis, length of = chromosomes=20 17, 10, and 7; Y axis, score of the evidence of LOH on = chromosome 10=20 or 17 or gain of gene copy number on chromosome 7. D-431 and = F-502=20 exhibit LOH on chromosome 10 accompanied by gain of genes = copy=20 number on chromosome 7, whereas W-98 and S-496 exhibit LOH = on=20 chromosomes 10 and 17 and lesser degree of gain of = chromosome 7.=20 Fibroblast cell line had no evidence of genomic = abnormalities.=20 B. Coexpression of neural and mesenchymal-associated = gene in=20 glioblastoma cell lines. Expression of NES and YKL-40 was = determined=20 using immunocytochemical analysis. Rat chondrosarcoma cell = lines=20 served as positive control cells for YKL-40. Representative = of four=20 glioblastoma cell lines. Magnification, x100. C. Specific = expression of=20 YKL-40 in glioblastoma cell lines. Semiquantitative RT-PCR = analysis=20 was done to determine the expression of YKL-40, EGFR, = insulin-like=20 growth factor-I receptor (IGFR), and vascular = endothelial=20 growth factor (VEGF) in various types of human cancer = cell=20 lines. Overexpression of EGFR, vascular endothelial growth = factor,=20 and insulin-like growth factor-I receptor was detected in = all tested=20 human cancer cell lines, whereas only glioblastoma cell = lines=20 uniquely express YKL-40 in the same culture condition (10% = serum),=20 indicative of mesenchymal origin. D. Glioblastoma = cell lines=20 express multiple MSC-associated genes. Semiquantitative = RT-PCR=20 analysis was done to verify that MSC-associated genes = identified in=20 primary glioblastoma tumors (Table = 1) are expressed in glioblastoma cell lines. Transcripts = of=20 multiple cell lineages in glioblastoma cell lines (W-98, = D-431,=20 F-502, U87-MG, and S-496), normal newborn foreskin = fibroblasts, and=20 peripheral blood lymphocytes (PBL) were analyzed. PCR = products were grouped based on the tissue lineage. All=20 determinations were done in duplicates. The full name of = each=20 labeled gene symbol is described in Table = 1. E. Differential expression of mesenchymal=20 lineage-associated gene in glioblastoma subtypes. Real-time=20 quantitative RT-PCR analysis of YKL-40 in glioblastoma tumor = subtypes, normal brain tissues, glioblastoma cell lines, = normal=20 fibroblast, and freshly peripheral blood lymphocytes was = done. The=20 quantitation of specific transcript in samples was = calculated and=20 expressed by the YKL-40 mRNA ratio to = glyceraldehyde-3-phosphate=20 dehydrogenase (GAPDH). =

 = ;
Glioblastoma=20 Cell Lines Expressed Surface Antigen Profile Similar to That of = MSC
To=20 test whether the glioblastoma cells express surface markers=20 associated with MSC, we determined the surface expression of=20 CD29 (integrin =DF1/fibronectin receptor), CD44 = (stromal=20 hyaluronic acid and osteopontin receptors), CD90 (Thy-1 cell=20 surface antigen), and CD105 [endoglin; transforming growth = factor-=DF3=20 (TGF-=DF3) receptor], four important surface markers = that have=20 been used partly for defining MSC (18, 25, 57),=20 in glioblastoma cell lines. Using a four-color=20 fluorescence-activated cell sorting analysis, the majority of = the=20 cell population in culture coexpressed all four antigens in = all three=20 primary glioblastoma cell lines [W-98 (61.7%), D-431 (67.3%), = and=20 F-502 (86.5%)], whereas negligible CD105+ cells = were=20 detected in the secondary glioblastoma cell line (S-496; Fig. = 3A ).=20 A lesser percentage of the long passaged U87-MG cells = expressed CD90=20 (7.4%) and CD105 (24.8%), whereas purified peripheral blood=20 lymphocytes had few positive cells for any of four markers. = All=20 glioblastoma cell lines are negative for CD14, CD34, and CD31 = (data=20 not shown). Other MSC-associated markers, including CD73, = CD109, and=20 CD140B mRNA, were also detected in all four glioblastoma cell = lines using RT-PCR analysis (data not shown).



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  		FIGURE 3. Expression of=20 MSC-associated surface markers in glioblastoma cells. = A.=20 Coexpression of CD90, CD105, CD29, and CD44 in glioblastoma = cell=20 lines analyzed using four-color fluorescence-activated cell = sorting=20 analysis. The percentage of cells coexpressing four surface = markers=20 in each cell line was calculated by percentage of cells = coexpressing=20 CD90 and CD105 multiplied by percentage of cells = coexpressing CD29=20 and CD44 in the cell population that are double positive for = CD90=20 and CD105. B. Specific expression of CD105 in primary = glioblastoma tumors. Representative immunohistochemical = staining of=20 CD105 in clinical glioblastoma subgroups and normal brain. A = subset=20 of the images from a tissue array. Strong positivity of = CD105=20 antibody staining was detected in two primary glioblastomas. = Negative staining was detected in two secondary = glioblastomas and=20 two normal brain cores. Endothelial cells were stained = positively=20 for CD105. The incidence of the expressions of CD105 in = primary=20 glioblastoma was 19 of 45, whereas no positive staining was = detected=20 in secondary glioblastoma (0 of 16) or normal brain tissue = (0 of=20 18). Magnification, x400. =

 = ;
To=20 determine whether the differential expression of CD105 detected=20 between primary and secondary glioblastoma cell lines was = also=20 observed in vivo, tissue microarrays were stained with=20 anti-CD105 antibody. The result indicted that CD105 was = strongly=20 expressed in a large fraction of malignant-appearing tumor = cells in=20 primary glioblastoma biopsies (19 of 45), whereas both = secondary=20 glioblastoma (0 of 16; P =3D 0.000867) and normal = brain tissue=20 (0 of 18; P =3D 0.0004856) were stained negatively for = CD105.=20 CD105 was strongly expressed by endothelial cells as = expected.=20

Differentiation Plasticity of Glioblastoma Cells
As the = both=20 primary glioblastoma tumors and their derived cell cultures = retained=20 the molecular expression pattern suggestive of a MSC-like=20 characteristics, we sought to functionally test whether = glioblastoma=20 cells possess stem-like plasticity. To prevent cell = selection, the=20 cell differentiation was tested in both cloned and noncloned = cell=20 cultures. Noncloned glioblastoma cells were treated with = adipogenic,=20 osteogenic, and chondrogenic induction medium and the cells = were=20 analyzed for the induction into the various cell types. Under = the=20 adipogenic treatment, three tested primary glioblastoma cell = lines=20 (W-98, D-431, and F-502) formed oil red-O-positive cells with = cytoplasmic accumulation of lipid vacuoles and eccentric = deviation of=20 nuclease within cells (Fig. = 4A ).=20 In contrast, the treated secondary glioblastoma cell line = (S-496)=20 only showed weak staining. The treated human foreskin = fibroblasts and=20 all nontreated glioblastoma cells were negative for oil red-O = staining. Osteogenic differentiation of glioblastoma cell = lines was=20 evident with the detection of alkaline phosphatase=96positive = cells (Fig. = 4B),=20 which were observed in all three induced primary glioblastoma = cell=20 lines. F-502, which showed the strongest activity of alkaline = phosphatase, also formed strong calcium deposits (Fig. = 4B),=20 which were stained with silver by von Kossa method, whereas = only few=20 deposits can be detected in the cultures of W-98 and D-431 = (data not=20 shown). In contrast, only a few alkaline = phosphatase=96positive=20 cells were identified in S-496 cultures and fibroblast = cultures.=20 Chondrogenic differentiation of glioblastoma cells was = induced=20 in serum-free medium supplemented with TGF-=DF3. Collagen = type=20 II=96positive cells were detected in all three induced = primary=20 glioblastoma cell lines (Fig. = 4C) by=20 immunohistochemical staining. Unexpectedly, collagen type = II=96positive=20 cells were also seen in the fibroblast culture. None of the=20 nontreated cells was positive for collagen type II. The = treated=20 secondary glioblastoma cell line that lack of CD105 marker = did not=20 survive through the culture of chondrogenic treatment in the=20 serum-free medium, suggesting that CD105 is indeed a = functional=20 marker for MSC and that chondrogenesis is driven by = TGF-=DF-CD105=20 signaling. The mesenchymal differentiation was further shown = in=20 the cloned and expanded glioblastoma cell lines as well as in = bone=20 marrow=96derived stromal cells (data not shown). The = transcription=20 level of lineage-specific genes in glioblastoma cells was = determined=20 using a real-time quantitative RT-PCR assay. Although the=20 lineage-specific protein cannot be detected in noninduced = cells (Fig. = 4D),=20 low levels of baseline mRNA expression were detected using = RT-PCR=20 amplification. As such, the highest amount of = lineage-specific mRNA=20 level postinduction did not always correspond with the = highest fold=20 increase when compared with baseline level. When compared = with=20 nontreated cultures, markedly increased lineage-specific mRNA = levels=20 of adipocyte (fatty acid=96binding protein 4), bone (alkaline = phosphatase), and cartilage (collagen type II) were detected = in=20 glioblastoma cell cultures from primary tumors, which were = treated=20 with the corresponding agent. The transcripts of alkaline=20 phosphatase were strongly induced (42-fold) in S-496 = (secondary=20 glioblastoma cell line). Cells with positive immunostaining = of=20 collagen type II were detected in a fibroblast cell culture = treated=20 with a chondrogenic medium. The quantitative RT-PCR, however, = displayed lower induction of collagen type II mRNA expression = when=20 compared with glioblastoma cell lines.



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  		FIGURE 4. Mesenchymal=20 differentiation plasticity of primary glioblastoma cells. = A.=20 Adipogenic differentiation. In comparison with nontreated = controls,=20 adipogenic differentiation in primary glioblastoma cell = cultures was=20 evident by the accumulation of lipid vesicles (W-98, D-431, = and=20 F-502) that stain with oil red-O. Such changes were not = observed in=20 cells derived from fibroblasts and lesser degree in = secondary=20 glioblastoma cells (S-496). Magnification, x400. B. Osteogenic = induction.=20 Osteogenic differentiation in primary glioblastoma cell = cultures=20 (W-98, D-431, and F-502) was indicated by the various degree = of=20 positive stain for alkaline phosphatase. Only a few positive = cells=20 were identified in secondary glioblastoma cell line (S-496) = and=20 cultured fibroblasts. No staining was detected in nontreated = cells.=20 F-502 cells stained by von Kossa technique show the presence = of=20 calcium. Magnification, x400.=20 C. Chondrogenic induction. Primary glioblastoma cells = treated=20 with chondrogenic medium show positive immunostaining for = the=20 collagen type II (F-502, D-431, and W-98). Lesser degree of = staining=20 was indicated in fibroblast cultures and negative staining = for=20 nontreated cells. Magnification, x400. D. Induction of=20 lineage-specific mRNA expression in glioblastoma cells = treated with=20 differentiation agents. A real-time quantitative RT-PCR = analysis of=20 lineage-specific mRNA expression was done in two sets of = nontreated,=20 adipogenic, osteogenic, and chondrogenic medium-treated cell = cultures. Total RNA was analyzed for the lineage-specific = mRNA=20 expression that is restricted to the adipocytic (fatty = acid=96binding=20 protein), osteoblastic (alkaline phosphatase), or = chondrocytic=20 (collagen type II) lineage. The quantitation of specific = transcripts=20 in cells was calculated and expressed by the = lineage-specific mRNA=20 ratio to glyceraldehyde-3-phosphate dehydrogenase. The fold = increase=20 was calculated by comparison of mRNA levels in treated and=20 nontreated samples. Representative of two sets of cultures. =

 = ;
Conversely,=20 when these glioblastoma cell lines were cultured in the = serum-free=20 medium supplemented with EGF and fibroblast growth factor = (NSC=20 culture condition), they formed glioblastoma spheres=20 (neurosphere-like) and could be passaged in sphere cultures = that=20 express CD133, NES, and SOX2.7=20 Moreover, these NSC-like glioblastoma spheres can be induced = for full=20 or partial differentiation into neuronal, oligodendrocytic, = and=20 astrocytic differentiation as described by others (4-= 7)= ,=20 suggesting that glioblastoma cells express stem-like = properties and=20 plasticity.


3D"   =20 Discussion
Top
Notes
Abstract
Introduction
Results
3D"Discussion
Materials and Methods
Acknowledgements
References
 
P= reviously,=20 we have used large-scale gene expression analysis to = characterize=20 primary and secondary glioblastomas. By comparing with = low-grade=20 astrocytoma, we have identified a series of glioblastoma-associated = genes that could distinguish primary glioblastomas from the=20 secondary glioblastomas (14). The=20 comparison with lower-grade astrocytomas was done to attempt=20 selecting for genes, which are specific to the end malignant=20 transformation into the highly invasive glioblastomas. = Secondary=20 glioblastoma-associated genes primarily include mitotic cell = cycle=20 components, suggesting loss of function in prominent cell = cycle=20 regulators, whereas primary glioblastoma-associated genes = highlight=20 genes expressed in mesenchyme-derived tissues and stromal = response,=20 suggesting the augmentation of extracellular signaling = operating the=20 malignancy. To identify genes potentially link to cellular = properties=20 and tumorigenesis of primary glioblastoma, in this study, we=20 compared primary glioblastoma with normal brain tissue. We=20 identified a series of fundamental MSC-associated genes = overexpressed=20 in glioblastoma biopsies, raising the question whether = primary=20 glioblastoma fundamentally possess mesenchymal properties or=20 acquire these properties under environmental guidance during=20 the tumor progression.

Evidently, that YKL-40, TNC, osteonectin, and CD105, = four=20 genes that are ontogenically associated with mesenchymal = tissues=20 but not to neural lineage, were overexpressed in primary=20 glioblastoma tumor cells suggest that primary glioblastoma = possess=20 mesenchymal properties. The finding of glioblastoma cell = lines=20 expressing cellular and molecular signatures of MSC and were = able to=20 be induced and differentiated into mesenchymal lineage cell=20 types further supports the concept that a subset of primary=20 glioblastoma possesses MSC-like properties. Many=20 bone/cartilage-associated factors have been implicated in=20 angiogenesis/neovascularization, cell proliferation, = antiapoptosis,=20 EMT, and cell migration; therefore, these = mesenchymal-associated=20 factors may participate in promoting tumorigenesis and = malignant=20 progression. If primary glioblastomas truly possess MSC-like=20 properties and constitutively express = bone/cartilage-associated=20 factors, it may explain in part for its developmental = aggressiveness=20 without an identifiable less malignant precursor lesion in = contrast=20 to that secondary glioblastoma. Indeed, our previous study, = which=20 includes 63 glioblastoma tumors (13),=20 showed that glioblastoma subtype (group HC2B) defined by=20 overexpression of ECM/mesenchymal components is associated = with=20 shorter survival and is enriched in primary glioblastoma (14).=20 Further, 52% (24 of 46) of primary glioblastoma overexpress=20 mesenchymal-associated genes, whereas 85% of recurrent = primary=20 glioblastoma that had previous treatment express mesenchymal=20 phenotype (14),=20 suggesting that mesenchymal properties confer the malignant = and=20 antiapoptotic phenotype. Loss of chromosome 10 and chromosome = 7/7p=20 amplification are the most frequently observed in primary=20 glioblastomas that are associated with poor prognosis (56). A=20 gain of chromosome 7 has been suggested to confer radiation=20 resistance (58). Many=20 mesenchymal-associated genes on chromosome 7, which are = up-regulated=20 in primary glioblastoma, were reported to be associated with = Akt=20 phosphorylation, antiapoptosis, hypoxia, angiogenesis, and = EMT (ref.=20 14; Table = 1).=20 Therefore, the overexpression of mesenchymal properties in=20 glioblastoma cells is likely to confer the resistance to = treatment=20 and tumor recurrence. Similar observations have been reported = by=20 Phillips et al. (55), which=20 indicate that glioblastoma characterized by resemblance to = tissue of=20 mesenchymal origin is associated with gain of chromosome 7=20 accompanied by a loss of chromosome 10, robust angiogenesis,=20 up-regulation of Akt activation, and overexpression of = YKL-40, CD44,=20 signal transducer and activator of transcription 3, and=20 vimentin.

Using tissue microarrays, we have verified four MSC-associated=20 genes that are overexpressed in primary glioblastoma cells = [i.e.,=20 YKL-40 (14),=20 TNC, osteonectin, and CD105], indicative of = mesenchymal=20 origin in a subset of primary glioblastoma. Glioblastoma = cells=20 express four MSC-associated surface markers that can be = induced=20 to differentiate into mesenchymal lineage-like cell types = defined=20 by morphologic, histologic, immunologic, and molecular=20 characteristics that have been well documented in the = literature.=20 Although up-regulation of tissue-specific genes = postdifferentiation=20 treatment supported the induction of mesenchymal lineage cell = type=20 differentiation, we, however, have observed differential=20 magnitude/degree of differentiation induction among the cells = in=20 cultures and between the cell lines, suggesting that = mesenchymal=20 glioblastoma cells are not normal MSC. Gene mutation may = prevent=20 poorly differentiated glioblastoma cells from terminal=20 differentiation (47) even=20 under the differentiation treatment. YKL-40 is a growth = factor=20 for connective tissue cells and a potent migration factor for = endothelial cells (59).=20 Recently, overexpression of YKL-40 was reported to be = associated with=20 poorer response to radiation and shorter overall survival in=20 glioblastomas (55, 60). TNC=20 is a secreted ECM protein highly up-regulated in many types = of=20 cancers and has been shown to play a role in promoting = angiogenesis=20 and invasion of human glioma cells (61-63).=20 Osteonectin is a secreted glycoprotein that binds to ECM and = promotes=20 tissue remodeling, angiogenesis, and embryonic development = (64). A=20 study showed that osteonectin mediates cellular survival of = gliomas=20 through Akt activation (65).=20 CD105, the TGF-=DF3 receptor, plays a role in TGF-=DF = signaling in the=20 control of chondrogenic and osteogenic differentiation (66).=20 TGF-=DF-CD105 signaling pathway, therefore, may contribute to = EMT=20 phenotype as well as the in vivo mesodermal = differentiation in=20 primary glioblastoma (12). This=20 hypothesis is further supported by the detection of = overexpression of=20 TGFBI gene in primary glioblastoma tumors, one of the = most=20 highly represented genes in MSC (25).=20 TGF-=DF signaling has been shown to stimulate tumor cell = motility,=20 invasiveness, neovascularization, and EMT. Synergistically, = CD44=20 (4-fold increase in glioblastoma tumors compared with normal = brain=20 tissue) is a cell surface receptor for hyaluronate and = osteopontin,=20 and their interactions can synergize tumor cell growth,=20 migration, and cellular chemotaxis (67).=20 Integrin =DF1 (CD29) is a predominant adhesion = receptor used=20 by stromal precursor cells for adhesion, proliferation, and=20 development into osteoblast-like cells (68). The=20 expression of Thy-1 (CD90) glycoprotein implicated a=20 myofibroblastic/EMT phenotype (69).=20 Therefore, the link between mesenchymal glioblastoma and poor = prognosis is likely triggered by the activation of=20 inflammatory/stromal/angiogenesis program driven by = MSC-associated=20 markers through autocrine and paracrine fashion in tumor = in=20 situ.

The identification of genes that are associated with embryonic=20 neural epithelial stem cells (e.g., SOX genes and = NES)=20 revealed the neural origin of primary glioblastoma as well as = its=20 stem-like status. SOX transcripts were also detected in = glioblastoma=20 cell lines (data not shown). NES and SOX proteins are often=20 regarded as markers for neural primordium and have been shown = to=20 have regulatory link (70). EMT=20 is the hallmark of embryo development and an essential = process that=20 governs morphogenesis (71-73).=20 Therefore, mesenchymal properties and highly invasive = phenotype=20 of primary glioblastoma may simply reflect the reactivation = of=20 the molecular properties of radial glial cells, which migrate = out of=20 the subventricular zone during embryogenesis. Alternatively, = gene=20 mutation, for instance, overexpression of EGFR gene or = PTEN=20 deletion, may initiate a distinct program of gene expression = and turn=20 on mesenchymal master genes. It has been shown that EGF but = not=20 platelet-derived growth factor can stimulate the = differentiation of=20 MSC into bone-forming cells (74).=20 TGF-=DF, Ras, and phosphatidylinositol 3-kinase/Akt = signaling,=20 components associated with EGFR and PTEN pathway, coordinated = activation EMT (70, 75-79), which=20 has been implicated in tumor recurrence and self-renewal (40).=20

In summary, we have shown that primary glioblastoma tumors and=20 cell lines express the molecular signatures of MSC and NSC.=20 These molecular properties may therefore confer their = capability=20 of differentiation into both neural and mesenchymal lineage=20 cell types. It is likely that these properties will greatly=20 affect the biological/pathologic behavior of the glioblastoma = cells in vivo not only in the developmental stage but also=20 during the malignant progression. This finding may affect the = design of effective therapies currently not considered for=20 primary glioblastomas that are more commonly used for = mesenchymal=20 origin tumors. Thus, MSC-like properties may play a role in = the=20 tumorigenesis, invasive progression, and tumor = recurrence.=20


3D"   =20 Materials and Methods
Top
Notes
Abstract
Introduction
Results
Discussion
3D"Materials and = Methods
Acknowledgements
References
 
<= EM>Tumor=20 Samples
Tumor samples presented here are derived from a = published=20 microarray study (14). The=20 patient tumors and normal samples were collected either from=20 autopsies of glioblastoma patients within 24 hours of death = or from=20 patients who underwent surgery at University of California at = Los=20 Angeles Medical Center. All samples were collected under = protocols=20 approved by the University of California at Los Angeles = Institutional=20 Review Board. All histopathologic typing and tumor grading = were done=20 by one neuropathologist (P.S.M.) according to the WHO = criteria. The=20 subgrouping of glioblastomas was based on clinical = presentation.=20 Secondary glioblastomas were called if there was previous = pathologic=20 evidence of lower-grade glioblastoma. All tumors without = prior=20 evidence of progression from a lower-grade tumor were = clinically=20 classified as primary glioblastomas.

Microarray Procedures and Data Analysis
Total RNA was = isolated=20 from tumor samples using a Trizol reagent (Invitrogen Life=20 Technologies, Carlsbad, CA). Complementary DNA was generated = and=20 converted to cRNA probes using standard Affymetrix protocols = and=20 hybridized to U133A oligonucleotide microarray (GeneChip = Human Genome=20 U133A, Affymetrix, Santa Clara, CA), which represents 3D~=2014,500 human = transcripts. The chips were scanned using the GeneArray = scanner=20 (Affymetrix). The CEL files generated by the Affymetrix = Microarray=20 Suite version 5.0 were converted into DCP files using the = DNA-Chip=20 Analyzer (dChip 1.3; http://biosun1.harvard= .edu/complab/dchip/).=20 The DCP files were globally normalized, and gene expression = values=20 were generated using the dChip implementation of = perfect-match minus=20 mismatch model-based expression index. The group comparisons = were=20 done in dChip. In addition, to avoid inclusion of low-level = and=20 unreliable signals, the higher signal needed to exceed 100 = and be=20 called present by Microarray Suite version 5.0 in >20% of = the=20 samples. Gene annotation and tissue distribution was obtained = from=20 published literature (PubMed), the GeneReport of the Source = database=20 (http://source.stanford.edu/),=20 human genome expression profile (http:/= /telethon.bio.unipd.it/bioinfo/HGXP_170/index.html#),=20 and University of California at Los Angeles normal tissue=20 transcription database (http://www.dev.gmod.org/). =

Cell Lines
Four permanent glioblastoma cell lines, W-98, = D-431,=20 F-502, and S-496, were established from clinical specimens. = W-98,=20 D-431, and F-502 were derived from patients with primary=20 glioblastoma and the S-496 cell line was derived from a = patient with=20 secondary glioblastoma. No evidence of histopathology showed=20 gliosarcoma biphasic pattern in tumors. Cell lines were = maintained in=20 DMEM/Ham's F-12 (Mediatech, Inc., Herndon, VA) supplemented = with 10%=20 fetal bovine serum, L-glutamine, and = antibiotics=20 (100 units/mL penicillin and 100 =B5g/mL streptomycin). = Glioblastoma=20 cell lines were further cloned at 0.5 cell per well in = 96-well plate=20 and the single-cell colonies were further expanded to = permanent=20 cell lines. The glioblastoma cell line U87-MG and a newborn=20 foreskin fibroblast cell line, Hs. 27, were purchased from = American=20 Type Culture Collection (Manassas, VA). Other types of human=20 tumor cell lines, rat chondrosarcoma cell line, and human = bone=20 marrow stromal cells as indicted in the text were obtained = from=20 multiple laboratories at University of California at Los = Angeles=20 and were maintained in the same culture condition. =

LOH Analysis
Genomic DNA (500 ng) from each cell line was = amplified, labeled, and hybridized under manufacturer's = recommended=20 conditions using the GeneChip Human Mapping 10K Array = XbaI 131=20 (Affymetrix). Raw allele scores were processed using = Affymetrix=20 GeneChip Chromosome Copy Number Tool 1.1 to estimate = genome-wide=20 chromosomal gains and losses.

Immunohistochemistry and Immunocytochemical Analysis
A=20 high-density glioblastoma tissue array was constructed consisting = of=20 three representative 0.6-mm cores from formalin-fixed, = paraffin-embedded=20 tissue blocks from each of 60 primary glioblastomas, 16 = secondary=20 glioblastomas, and 15 corresponding normal brain tissues. = Microscope=20 slides were treated with 0.01 mol/L sodium citrate buffer (pH = 6.0). A 1-hour blocking step was done using 2% normal horse=20 serum followed by the application of primary antibody to TNC=20 (1:200; Chemicon, Temecula, CA), osteonectin (1:1,000; = Chemicon),=20 CD105 (1:400; Invitrogen), or control antibody overnight at=20 4=B0C. Subsequent immunodetection was done using Vectastain = ABC=20 Standard kit (Vector Laboratories, Burlingame, CA) and Vector = NovaRED=20 (Vector Laboratories). Staining intensity in tissue array was = scored=20 by a neuropathologist (K.Y.) based on a scale of 0 to 2, in = which=20 negatively stained specimens were graded 0, weakly positive = samples=20 were graded 1, and strongly positive spots were graded 2. The = significance of differences in the incidence of marker = expression in=20 primary and secondary glioblastomas or normal brain tissue = was=20 calculated using one-tailed, two-proportion Z-test.=20 Immunocytochemical staining was done on cell culture, which = was=20 seeded on an eight-chamber culture slide (Nunc, Rochester, = NY)=20 overnight. Cells were fixed for 30 minutes with 4% formaldehyde=20 solution and permeablized with 0.3% Triton X-100/PBS for 10=20 minutes followed by incubation with 5% goat serum for 20 = minutes.=20 After washing with PBS, cells were incubated for 2 hour with=20 anti-YKL-40, anti-NES, control antibody, or no first = antibody.=20 After washing, cells were incubated with rhodamine red or = Alexa=20 Fluor 488=96conjugated goat anti-mouse IgG (1:200). The = cells=20 were counterstained with Hoechst 33342 to identify all = nuclei.=20

Fluorescence-Activated Cell Sorting=20 Analysis
Fluorescence-activated cell sorting analyses were done = to=20 analyze MSC antigen markers in glioblastoma cell lines.=20 Glioblastoma cells (5 x=20 105) were stained with antibody cocktails for 30 = minutes=20 at 4=B0C and the free antibody was removed by two washes. The = analyses=20 were done on a FACSCalibur flow cytometer (Becton Dickinson, = San=20 Jose, CA) and 3D≥10,000 events were collected in each analysis with = forward=20 scatter and side scatter as well as four fluorescent = measurements:=20 FL1 (FITC), FL2 (PE), FL3 (PE-Cy5), and FL4 (APC). Data were = analyzed=20 by using CellQuest 3.1 (De Novo Software, Thornhill, Ontario, = Canada). The following antibodies were employed: CD44-FITC, = CD105-PE,=20 CD90-APC, CD29-TC, CD34-FITC, CD14-FITC, CD31, and isotype = control=20 antibodies (Becton Dickinson; Caltag Laboratories, = Burlingame, CA;=20 and R&D Systems, Inc., Minneapolis, MN). For four-color = analyses,=20 cells were gated for double positive for CD90-APC and = CD105-PE=20 and then analyzed for their coexpression of CD44-FITC and=20 CD29-TC.

In vitro Induction of Multiple Cell Lineage=20 Differentiation
The mesenchymal lineage differentiation was = assessed in=20 cloned and expanded glioblastoma cell lines. Adipogenic=20 differentiation was assessed by incubating cells with DMEM-LG = plus=20 10% fetal bovine serum supplemented with 0.5 =B5mol/L=20 hydrocortisone, 0.5 =B5mol/L isobutyl methylxanthine, and 60=20 =B5mol/L indomethacin (Sigma-Aldrich, St. Louis, MO) for 2 = weeks.=20 Osteogenic inductions were carried out by incubating cells = with=20 DMEM-LG supplemented with 10% fetal bovine serum, = 10=968=20 mol/L dexamethasone, 0.2 mmol/L ascorbic acid, and 10 mmol/L=20 =DF-glycerophosphate (Sigma-Aldrich) for 3 weeks. = Chondrogenic=20 inductions were carried out in suspension culture of = micromass=20 pellets or adherent cultures with high cell density. Cells = were=20 incubated with serum-free DMEM-LG supplemented with 10 ng/mL = TGF-=DF3=20 (R&D Systems), 100 nmol/L dexamethasone, 50 =B5g/mL = ascorbic=20 acid, 100 =B5g/mL sodium pyruvate, 40 =B5g/mL proline=20 (Sigma-Aldrich), and ITS Premix (BD Biosciences, San Jose, = CA)=20 for 3 weeks. The medium was changed every 3 days. Cells = treated=20 postadipogenic induction was stained with oil red-O solution=20 (Sigma-Aldrich) to reveal adipogenic differentiation. To = assess=20 osteogenic differentiation and mineralization, cells were = stained=20 with alkaline phosphatase staining (Sigma-Aldrich) and von = Kossa=20 staining (Newcomer Supply, Middleton, WI). = Immunohistochemical=20 staining for collagen type II (Lab Vision Corp., Fremont, CA) = was used to assess the chondrogenic differentiation.

Semiquantitative and Real-time Quantitative=20 RT-PCR
Semiquantitative and real-time quantitative RT-PCR was = done=20 to verify transcripts of multiple cell lineages in tested = samples.=20 The specific primers were designed from published sequence of = mRNA (3'-untranslated region; National Center for = Biotechnology=20 Information). The Primer 3 Input (primer3_www.cgi v 0.2) was=20 used to selected primers, and nonredundant specific primer = sequences=20 were verified using BLAST Search Genome (http://genome.ucsc.edu/) = and=20 National Center for Biotechnology Information BLAST (http://www.ncbi.nlm.= nih.gov/blast/Blast.cgi).=20 The primer sequences and expected size of amplified PCR = products=20 are listed in Supplementary Table S2. All RNA samples were = digested=20 with DNase I (Ambion, Inc., Austin, TX) that free off RNase=20 before reverse transcription. Total RNA (2 =B5g) was used = as a=20 template for RT-PCR. cDNA synthesis was done for 1 cycle at = 50=B0C for=20 30 minutes and 94=B0C for 2 minutes, and PCR amplification = was carried=20 out for 30 cycles [50=B0C for 2 minutes and 95=B0C for 10 = minutes (94=B0C=20 for 15 seconds, 58-61=B0C for 1 minute, and 72=B0C for 1 = minute) x 30 cycles]. After = amplification, each=20 reaction product (5 =B5L) was analyzed by 2% agarose gel=20 electrophoresis, and the bands were then visualized by SYBR = Green=20 staining. The specificity of the selected PCR products was = confirmed=20 by sequencing. Real-time PCR was done to amplify = tissue-specific=20 transcripts and was carried out with MJ Opticon PCR Analyzer = (MJ=20 Research, Inc., Waltham, MA) using SYBR Green PCR Core = Reagents=20 (Applied Biosystems, Foster City, CA). The reactions were = cycled 30=20 times [50=B0C for 2 minutes and 95=B0C for 10 minutes (94=B0C = for 15=20 seconds, 60=B0C for 1 minute, and 72=B0C for 1 minute) x 30 cycles] and the = fluorescence was=20 measured at the end of each cycle to construct amplification = curves.=20 A melting curve was done to verify the specificity of PCR = products.=20 Quantitation of transcripts was calculated based on a = titrated=20 standard curve co-run in the same experiment and calibrated = with the=20 expression level of housekeeping gene. All determinations = were done=20 in duplicate. The following tissue-specific oliogonucleotides = were=20 used: fatty acid=96binding protein 4 (210 bp) sense=20 5'-AAGTCAAGAGCACCATAACCTTAGA-3' and antisense=20 5'-TGGCTTATGCTCTCTCATAAACTCT-3', alkaline phosphatase (236 = bp) sense=20 5-GAGTACAGACTGCAGACATTCTCAA-3' and antisense=20 5'-GTCCTGAGGAGAA-AGACCTCAAC-3', and collagen type II, 3D{alpha}=201 = (224 bp)=20 sense 5'-CTTTCCAATCTCAGTCACTCTAGGA-3' and antisense=20 5'-ATTTGACTCACACCAGTTAGTTTCC.

Accession Numbers
The expression microarray and single = nucleotide=20 polymorphism array data have been submitted to the Gene = Expression=20 Omnibus database at http://www.ncbi.nlm.ni= h.gov/projects/geo/.=20 The accession number for expression microarray is GSE5107=20 and the accession number for single nucleotide polymorphism=20 expression microarray is GSE5082.=20


3D"   =20 Acknowledgements
Top
Notes
Abstract
Introduction
Results
Discussion
Materials and Methods
3D"Acknowledgements
References
 
W= e thank=20 Harley Kornblum and Daniel H. Geschwind for useful comments = and the=20 patients who participated in this study.


3D"    Notes=20
Top
3D"Notes
Abstract
Introduction
Results
Discussion
Materials and Methods
Acknowledgements
References
 
<= A=20 name=3D"">Grant support: National Cancer = Institute grant=20 U01CA88173, Accelerate Brain Cancer Cure, the Henry Singleton = Brain=20 Tumor Program, and UCLA Jonsson Comprehensive Cancer Center = seed=20 grant.

The costs of publication of this = article were=20 defrayed in part by the payment of page charges. This article = must=20 therefore be hereby marked advertisement in accordance with = 18=20 U.S.C. Section 1734 solely to indicate this fact.

Note: Supplementary data for = this article=20 are available at Molecular Cancer Research Online (http://mcr.aacrjournals.org/).<= SUP>=20

7 Unpublished data. = 3DBack

Received 1/ 9/06; revised 6/21/06; accepted 6/26/06.


3D"   =20 References
Top
Notes
Abstract
Introduction
Results
Discussion
Materials and Methods
Acknowledgements
3D"References
&nb= sp;

  1. Brat DJ, Castellano-Sanchez A, Kaur B, Van Meir EG. = Genetic and=20 biologic progression in astrocytomas and their relation to angiogenic=20 dysregulation [review]. Adv Anat Pathol 2002;9:24=9636.[CrossRef][Medline]
  2. Watanabe K, Tachibana O, Sata K, Yonekawa Y, Kleihues P, = Ohgaki H.=20 Overexpression of the EGF receptor and p53 mutations are mutually = exclusive in=20 the evolution of primary and secondary glioblastomas. Brain Pathol=20 1996;6:217=9623.[Medline]
  3. Ohgaki H, Dessen P, Jourde B, et al. Genetic pathways to = glioblastoma: a population-based study. Cancer Res = 2004;64:6892=969.[Abstract/Free Full Text]
  4. Galli R, Binda E, Orfanelli U, et al. Isolation and=20 characterization of tumorigenic, stem-like neural precursors from = human=20 glioblastoma. Cancer Res 2004;64:7011=9621.[Abstract/Free Full Text]
  5. Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem = cells can=20 arise from pediatric brain tumors. Proc Nat Acad Sci U S A = 2003;100:15178=9683.[Abstract/Free Full Text]
  6. Singh SK, Hawkins C, Clarke ID, et al. Identification of = human=20 brain tumour initiating cells. Nature 2004;432:396=96401.[CrossRef][Medline]
  7. Yuan X, Curtin J, Xiong Y, et al. Isolation of cancer = stem cells=20 from adult glioblastoma multiforme. Oncogene 2004;23:9392=96400.[CrossRef][Medline]
  8. Passegue E, Jamieson CH, Ailles LE, Weissman IL. Normal = and=20 leukemic hematopoiesis: are leukemias a stem cell disorder or a = reacquisition=20 of stem cell characteristics? [review]. Proc Natl Acad Sci U S A = 2003;100=20 Suppl 1:11842=969.
  9. Marx J. Mutant stem cells may seed cancer. Science=20 2003;301:1308=9610.[Abstract/Free Full Text]
  10. McKeever PE, Davenport RD, Shakui P. Patterns of = antigenic=20 expression of human glioma cells [review]. Crit Rev Neurobiol = 1991;6:119=9647.[Medline]
  11. McKeever PE, Varani J, Papadopoulos SM, Wang M, McCoy = JP.=20 Products of cells from gliomas. IX. Evidence that two fundamentally = different=20 mechanisms change extracellular matrix expression by gliomas. J = Neurooncol=20 1995;24:267=9680.[CrossRef][Medline]
  12. Jacobsen PF, Papadimitriou JM. Mesenchymal = differentiation of=20 cell lines obtained from human gliomas inoculated into nude mice. = Cancer=20 1989;63:682=9692.[Medline]
  13. Freije WA, Castro-Vargas FE, Fang Z, et al. Gene = expression=20 profiling of gliomas strongly predicts survival. Cancer Res = 2004;64:6503=9610.[Abstract/Free Full Text]
  14. Tso CL, Freije WA, Day A, et al. Distinct transcription = profiles=20 of primary and secondary glioblastoma subgroups. Cancer Res = 2006;66:159=9667.
  15. Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi = AL.=20 Turning brain into blood: a hematopoietic fate adopted by adult neural = stem=20 cells in vivo. Science=20 1999;283:534=967.[Abstract/Free Full Text]
  16. Galli R, Borello U, Gritti A, et al. Skeletal myogenic = potential=20 of human and mouse neural stem cells. Nat Neurosci = 2000;3:986=9691.[CrossRef][Medline]
  17. Wurmser AE, Nakashima K, Summers RG, et al. Cell=20 fusion-independent differentiation of neural stem cells to the = endothelial=20 lineage. Nature 2004;430:350=966.[CrossRef][Medline]
  18. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage = potential=20 of adult human mesenchymal stem cells. Science 1999;284:143=967.[Abstract/Free Full Text]
  19. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells = migrate=20 throughout forebrain and cerebellum, and they differentiate into = astrocytes=20 after injection into neonatal mouse brains. Proc Natl Acad Sci U S A=20 1999;96:10711=966.[Abstract/Free Full Text]
  20. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat = and human=20 bone marrow stromal cells differentiate into neurons. J Neurosci Res=20 2000;61:364=9670.3.0.CO;2-C&link_type=3DDOI">[C= rossRef][Medline]
  21. Seshi B, Kumar S, King D. Multilineage gene expression = in human=20 bone marrow stromal cells as evidenced by single-cell microarray = analysis.=20 Blood Cells Mol Dis 2003;31:268=9685.[CrossRef][Medline]
  22. Tremain N, Korkko J, Ibberson D, Kopen GC, DiGirolamo = C, Phinney=20 DG. MicroSAGE analysis of 2,353 expressed genes in a single = cell-derived=20 colony of undifferentiated human mesenchymal stem cells reveals mRNAs = of=20 multiple cell lineages. Stem Cells 2001;9:408=9618.
  23. Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, = Lemischka IR,=20 Moore KA. A molecular profile of a hematopoietic stem cell niche. Proc = Natl=20 Acad Sci U S A 2002;99:13061=966.[Abstract/Free Full Text]
  24. Jia L, Young MF, Powell J, et al. Gene expression = profile of=20 human bone marrow stromal cells: high-throughput expressed sequence = tag=20 sequencing analysis. Genomics 2002;79:7=9617.[CrossRef][Medline]
  25. Silva WA, Jr., Covas DT, Panepucci RA, et al. The = profile of gene=20 expression of human marrow mesenchymal stem cells. Stem Cells = 2003;21:661=969.[Abstract/Free Full Text]
  26. Terskikh AV, Easterday MC, Li L, et al. From = hematopoiesis to=20 neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad = Sci U S=20 A 2001;98:7934=969.[Abstract/Free Full Text]
  27. Kang SK, Putnam L, Dufour J, Ylostalo J, Jung JS, = Bunnell BA.=20 Expression of telomerase extends the lifespan and enhances osteogenic=20 differentiation of adipose tissue-derived stromal cells. Stem Cells=20 2004;22:1356=9672.[Abstract/Free Full Text]
  28. Foster LJ, Zeemann PA, Li C, Mann M, Jensen ON, Kassem = M.=20 Differential expression profiling of membrane proteins by quantitative = proteomics in a human mesenchymal stem cell line undergoing osteoblast = differentiation. Stem Cells 2005;3:1367=9677.
  29. Mackie EJ, Tucker RP. Tenascin in bone morphogenesis: = expression=20 by osteoblasts and cell type-specific expression of splice variants. J = Cell=20 Sci 1992;103:765=9671.[Abstract]
  30. Malaval L, Modrowski D, Gupta AK, Aubin JE. Cellular = expression=20 of bone-related proteins during in vitro osteogenesis in rat = bone=20 marrow stromal cell cultures. J Cell Physiol 1994;158:555=9672.[CrossRef][Medline]
  31. Hu Z, Peel SA, Ho SK, Sandor GK, Clokie CM. Role of = bovine bone=20 morphogenetic proteins in bone matrix protein and osteoblast-related = gene=20 expression during rat bone marrow stromal cell differentiation. J = Craniofac=20 Surg 2005;16:1006=9614.[Medline]
  32. Luo Q, Kang Q, Si W, et al. Connective tissue growth = factor=20 (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling = in=20 osteoblast differentiation of mesenchymal stem cells. J Biol Chem=20 2004;279:55958=9668.[Abstract/Free Full Text]
  33. Gillette JM, Nielsen-Preiss SM. The role of Annexin 2 = in=20 osteoblastic mineralization. J Cell Sci 2004;117:441=969.[Abstract/Free Full Text]
  34. Massicotte F, Fernandes JC, Martel-Pelletier J, = Pelletier JP,=20 Lajeunesse D. Modulation of insulin-like growth factor 1 levels in = human=20 osteoarthritic subchondral bone osteoblasts. Bone 2006;38:33=9641.
  35. Rutter MM, Markoff E, Clayton L, et al. = Osteoblast-specific=20 expression of insulin-like growth factor-1 in bone of transgenic mice = induces=20 insulin-like growth factor binding protein-5. Bone = 2005;36:224=9631.[Medline]
  36. Owen TA, Smock SL, Prakash S, et al. Identification and = characterization of the genes encoding human and mouse osteoactivin. = Crit Rev=20 Eukaryot Gene Expr 2003;13:205=9620.[Medline]
  37. Hong JH, Hwang ES, McManus MT, et al. TAZ, a = transcriptional=20 modulator of mesenchymal stem cell differentiation. Science = 2005;309:1074=968.[Abstract/Free Full Text]
  38. Beiter K, Hiendlmeyer E, Brabletz T, et al. =DF-Catenin = regulates=20 the expression of tenascin-C in human colorectal tumors. Oncogene=20 2005;24:8200=964.[Medline]
  39. Rich JN, Shi Q, Hjelmeland M, et al. Bone-related genes = expressed=20 in advanced malignancies induce invasion and metastasis in a = genetically=20 defined human cancer model. J Biol Chem 2003;78:15951=967.
  40. Moody SE, Perez D, Pan TC, et al. The transcriptional = repressor=20 Snail promotes mammary tumor recurrence. Cancer Cell = 2005;8:197=96209.[CrossRef][Medline]
  41. Philip B, Lu Z, Gao Y. Regulation of GDF-8 signaling by = the p38=20 MAPK. Cell Signal 2005;17:365=9675.[CrossRef][Medline]
  42. Kamanga-Sollo E, Pampusch MS, White ME, Dayton WR. Role = of=20 insulin-like growth factor binding protein (IGFBP)-3 in TGF-=DF- and = GDF-8=20 (myostatin)-induced suppression of proliferation in porcine embryonic = myogenic=20 cell cultures. J Cell Physiol 2003;197:225=9631.[CrossRef][Medline]
  43. James PL, Stewart CE, Rotwein P. Insulin-like growth = factor=20 binding protein-5 modulates muscle differentiation through an = insulin-like=20 growth factor-dependent mechanism. J Cell Biol 1996;133:683=9693.[Abstract/Free Full Text]
  44. Wyzykowski JC, Winata TI, Mitin N, Taparowsky EJ, = Konieczny SF.=20 Identification of novel MyoD gene targets in proliferating myogenic = stem=20 cells. Mol Cell Biol 2002;22:6199=96208.[Abstract/Free Full Text]
  45. Moldes M, Boizard M, Liepvre XL, Feve B, Dugail I, = Pairault J.=20 Functional antagonism between inhibitor of DNA binding (Id) and = adipocyte=20 determination and differentiation factor 1/sterol regulatory = element-binding=20 protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty = acid=20 synthase promoter in adipocytes. Biochem J 1999;344 Pt 3:873=9680.
  46. Ellis P, Fagan BM, Magness ST, et al. SOX2, a = persistent marker=20 for multipotential neural stem cells derived from embryonic stem = cells, the=20 embryo or the adult. Dev Neurosci 2004;26:148=9665.[CrossRef][Medline]
  47. Boyer LA, Lee TI, Cole MF, et al. Core transcriptional = regulatory=20 circuitry in human embryonic stem cells. Cell 2005;122:947=9656.[CrossRef][Medline]
  48. Cheung M, Abu-Elmagd M, Clevers H, Scotting PJ. Roles = of Sox4 in=20 central nervous system development. Brain Res Mol Brain Res = 2000;79:180=9691.[Medline]
  49. Reppe S, Rian E, Jemtland R, Olstad OK, Gautvik VT, = Gautvik KM.=20 Sox-4 messenger RNA is expressed in the embryonic growth plate and = regulated=20 via the parathyroid hormone/parathyroid hormone-related protein = receptor in=20 osteoblast-like cells. J Bone Miner Res 2000;15:2402=9612.[CrossRef][Medline]
  50. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek A, = Silberstein LE. Human bone marrow stromal cells express a distinct set = of=20 biologically functional chemokine receptors. Stem Cells = 2006;24:1030=9641.
  51. Imitola J, Raddassi K, Park KI, et al. Directed = migration of=20 neural stem cells to sites of CNS injury by the stromal cell-derived = factor=20 13D{alpha}/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A = 2004;101:18117=9622.[Abstract/Free Full Text]
  52. Zhou Y, Larsen PH, Hao C, Yong VW. CXCR4 is a major = chemokine=20 receptor on glioma cells and mediates their survival. J Biol Chem=20 2002;277:49481=967.[Abstract/Free Full Text]
  53. Rubin JB, Kung AL, Klein RS, et al. A small-molecule = antagonist=20 of CXCR4 inhibits intracranial growth of primary brain tumors. Proc = Natl Acad=20 Sci U S A 2003;100:13513=968.[Abstract/Free Full Text]
  54. Ladi E, Nichols JT, Ge W, et al. The divergent DSL = ligand Dll3=20 does not activate Notch signaling but cell autonomously attenuates = signaling=20 induced by other DSL ligands. J Cell Biol 2005;170:983=9692.[Abstract/Free Full Text]
  55. Phillips HS, Kharbanda S, Chen R, et al. Molecular = subclasses of=20 high-grade glioma predict prognosis, delineate a pattern of disease=20 progression, and resemble stages in neurogenesis. Cancer Cell = 2006;9:157=9673.[CrossRef][Medline]
  56. Arslantas A, Artan S, Oner U, et al. The importance of = genomic=20 copy number changes in the prognosis of glioblastoma multiforme. = Neurosurg Rev=20 2004;27:58=9664.[Medline]
  57. Vogel W, Grunebach F, Messam CA, Kanz L, Brugger W, = Buhring HJ.=20 Heterogeneity among human bone marrow-derived mesenchymal stem cells = and=20 neural progenitor cells. Haematologica 2003;88:126=9633.[Abstract/Free Full Text]
  58. Misra A, Pellarin M, Hu L, et al. Chromosome transfer = experiments=20 link regions on chromosome 7 to radiation resistance in human = glioblastoma=20 multiforme. Genes Chromosomes Cancer 2006;4:20=9630.
  59. Nishikawa KC, Millis AJ. gp38k (CHI3L1) is a novel = adhesion and=20 migration factor for vascular cells. Exp Cell Res = 2003;287:79=9687.[CrossRef][Medline]
  60. Pelloski CE, Mahajan A, Maor M, et al. YKL-40 = expression is=20 associated with poorer response to radiation and shorter overall = survival in=20 glioblastoma. Clin Cancer Res 2005;11:3326=9634.[Abstract/Free Full Text]
  61. Zagzag D, Shiff B, Jallo GI, et al. Tenascin-C promotes = microvascular cell migration and phosphorylation of focal adhesion = kinase.=20 Cancer Res 2002;62:2660=968.[Abstract/Free Full Text]
  62. Herold-Mende C, Mueller MM, Bonsanto MM, et al. = Clinical impact=20 and functional aspects of tenascin-C expression during glioma = progression. Int=20 J Cancer 2002;98:362=969.[CrossRef][Medline]
  63. Ruiz C, Huang W, Hegi ME, et al. Growth promoting = signaling by=20 tenascin-C. Cancer Res 2004;64:7377=9685.[Abstract/Free Full Text]
  64. Framson PE, Sage EH. SPARC and tumor growth: where the = seed meets=20 the soil? J Cell Biochem 2004;9:679=9690.
  65. Shi Q, Bao S, Maxwell JA, et al. Secreted protein = acidic, rich in=20 cysteine (SPARC), mediates cellular survival of gliomas through AKT=20 activation. J Biol Chem 2004;279:52200=969.[Abstract/Free Full Text]
  66. Barry FP, Boynton RE, Haynesworth S, Murphy JM, Zaia J. = The=20 monoclonal antibody SH-2, raised against human mesenchymal stem cells, = recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun=20 1999;265:134=969.[CrossRef][Medline]
  67. Weber GF, Ashkar S, Glimcher MJ, Cantor H. = Receptor-ligand=20 interaction between CD44 and osteopontin (Eta-1). Science = 1996;271:509=9612.[Abstract]
  68. Gronthos S, Simmons PJ, Graves SE, Robey PG. = Integrin-mediated=20 interactions between human bone marrow stromal precursor cells and the = extracellular matrix. Bone 2001;28:74=96181.
  69. Koumas L, Smith TJ, Feldon S, Blumberg N, Phipps RP. = Thy-1=20 expression in human fibroblast subsets defines myofibroblastic or=20 lipofibroblastic phenotypes. Am J Pathol 2003;63:1291=96300.
  70. Tanaka S, Kamachi Y, Tanouchi A, Hamada H, Jing N, = Kondoh H.=20 Interplay of SOX and POU factors in regulation of the Nestin gene in = neural=20 primordial cells. Mol Cell Biol 2004;24:8834=9646.[Abstract/Free Full Text]
  71. Prindull G, Zipori D. Environmental guidance of normal = and tumor=20 cell plasticity: epithelial mesenchymal transitions as a paradigm = [review].=20 Blood 2004;103:2892=969.[Abstract/Free Full Text]
  72. Fleming TP, Sheth B, Fesenko I. Cell adhesion in the=20 preimplantation mammalian embryo and its role in trophectoderm = differentiation=20 and blastocyst morphogenesis. Front Biosci 2001;6:D1000.[Medline]
  73. Petersen OW, Lind Nielsen H, Gudjonsson T, Villadsen R, = Ronnov-Jessen L, Bissell MJ. The plasticity of human breast carcinoma = cells is=20 more than epithelial to mesenchymal conversion [review]. Breast Cancer = Res=20 2001;3:213=967.[CrossRef][Medline]
  74. Kratchmarova I, Blagoev B, Haack-Sorensen M, Kassem M, = Mann M.=20 Mechanism of divergent growth factor effects in mesenchymal stem cell=20 differentiation. Science 2005;308:1472=967.[Abstract/Free Full Text]
  75. Janda E, Lehmann K, Killisch I, et al. Ras and TGF = cooperatively=20 regulate epithelial cell plasticity and metastasis: dissection of Ras=20 signaling pathways. J Cell Biol 2002;156:299=96313.[Abstract/Free Full Text]
  76. Lehmann K, Janda E, Pierreux CE, et al. Raf induces = TGF=DF=20 production while blocking its apoptotic but not invasive responses: a=20 mechanism leading to increased malignancy in epithelial cells. Genes = Dev=20 2000;14:2610=9622.[Abstract/Free Full Text]
  77. Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E. = TGF-=DF1=20 and Ha-Ras collaborate in modulating the phenotypic plasticity and=20 invasiveness of epithelial tumor cells. Genes Dev = 1996;10:2462=9677.[Abstract/Free Full Text]
  78. Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, = Fuller GN.=20 Combined activation of Ras and Akt in neural progenitors induces = glioblastoma=20 formation in mice. Nat Genet 2000;25:55=967.[CrossRef][Medline]
  79. Guha A, Mukherjee J. Advances in the biology of = astrocytomas=20 [review]. Curr Opin Neurol 2004;17:655=9662.[CrossRef][Medline]


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=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_00DF_01C8F646.47BE8130 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://mcr.aacrjournals.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else if (name =3D=3D "margin-right") {=0A= e.style.marginRight =3D value;=0A= }=0A= else if (name =3D=3D "margin-top") {=0A= e.style.marginTop =3D value;=0A= }=0A= else if (name =3D=3D "min-height") {=0A= e.style.minHeight =3D value;=0A= }=0A= else if (name =3D=3D "overflow") {=0A= e.style.overflow =3D value;=0A= }=0A= else if (name =3D=3D "overflow-x") {=0A= e.style.overflowX =3D value;=0A= }=0A= else if (name =3D=3D "overflow-y") {=0A= e.style.overflowY =3D value;=0A= }=0A= else if (name =3D=3D "padding") {=0A= e.style.padding =3D value;=0A= }=0A= else if (name =3D=3D "padding-bottom") {=0A= e.style.paddingBottom =3D value;=0A= }=0A= else if (name =3D=3D "padding-left") {=0A= e.style.paddingLeft =3D value;=0A= }=0A= else if (name =3D=3D "padding-right") {=0A= e.style.paddingRight =3D value;=0A= }=0A= else if (name =3D=3D "padding-top") {=0A= e.style.paddingTop =3D value;=0A= }=0A= else if (name =3D=3D "page-break-after") {=0A= e.style.pageBreakAfter =3D value;=0A= }=0A= else if (name =3D=3D "page-break-before") {=0A= e.style.pageBreakBefore =3D value;=0A= }=0A= else if (name =3D=3D "pixelBottom") {=0A= e.style.pixelBottom =3D value;=0A= }=0A= else if (name =3D=3D "pixelHeight") {=0A= e.style.pixelHeight =3D value;=0A= }=0A= else if (name =3D=3D "pixelLeft") {=0A= e.style.pixelLeft =3D value;=0A= }=0A= else if (name =3D=3D "pixelRight") {=0A= e.style.pixelRight =3D value;=0A= }=0A= else if (name =3D=3D "pixelTop") {=0A= e.style.pixelTop =3D value;=0A= }=0A= else if (name =3D=3D "pixelWidth") {=0A= e.style.pixelWidth =3D value;=0A= }=0A= else if (name =3D=3D "posBottom") {=0A= e.style.posBottom =3D value;=0A= }=0A= else if (name =3D=3D "posHeight") {=0A= e.style.posHeight =3D value;=0A= }=0A= else if (name =3D=3D "position") {=0A= e.style.position =3D value;=0A= }=0A= else if (name =3D=3D "posLeft") {=0A= e.style.posLeft =3D value;=0A= }=0A= else if (name =3D=3D "posRight") {=0A= e.style.posRight =3D value;=0A= }=0A= else if (name =3D=3D "posTop") {=0A= e.style.posTop =3D value;=0A= }=0A= else if (name =3D=3D "posWidth") {=0A= e.style.posWidth =3D value;=0A= }=0A= else if (name =3D=3D "right") {=0A= e.style.right =3D value;=0A= }=0A= else if (name =3D=3D "ruby-align") {=0A= e.style.rubyAlign =3D value;=0A= }=0A= else if (name =3D=3D "ruby-overhang") {=0A= e.style.rubyOverhang =3D value;=0A= }=0A= else if (name =3D=3D "ruby-position") {=0A= e.style.rubyPosition =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-3dlight-color") {=0A= e.style.scrollbar3dLightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-arrow-color") {=0A= e.style.scrollbarArrowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-base-color") {=0A= e.style.scrollbarBaseColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-darkshadow-color") {=0A= e.style.scrollbarDarkShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-face-color") {=0A= e.style.scrollbarFaceColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-highlight-color") {=0A= e.style.scrollbarHighlightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-shadow-color") {=0A= e.style.scrollbarShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-track-color") {=0A= e.style.scrollbarTrackColor =3D value;=0A= }=0A= else if (name =3D=3D "float") {=0A= e.style.styleFloat =3D value;=0A= }=0A= else if (name =3D=3D "table-layout") {=0A= e.style.tableLayout =3D value;=0A= }=0A= else if (name =3D=3D "text-align") {=0A= e.style.textAlign =3D value;=0A= }=0A= else if (name =3D=3D "text-align-last") {=0A= e.style.textAlignLast =3D value;=0A= }=0A= else if (name =3D=3D "text-autospace") {=0A= e.style.textAutospace =3D value;=0A= }=0A= else if (name =3D=3D "text-decoration") {=0A= e.style.textDecoration =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationBlink") {=0A= e.style.textDecorationBlink =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationLineThrough") {=0A= e.style.textDecorationLineThrough =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationNone") {=0A= e.style.textDecorationNone =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationOverline") {=0A= e.style.textDecorationOverline =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationUnderline") {=0A= e.style.textDecorationUnderline =3D value;=0A= }=0A= else if (name =3D=3D "text-indent") {=0A= e.style.textIndent =3D value;=0A= }=0A= else if (name =3D=3D "text-justify") {=0A= e.style.textJustify =3D value;=0A= }=0A= else if (name =3D=3D "text-kashida-space") {=0A= e.style.textKashidaSpace =3D value;=0A= }=0A= else if (name =3D=3D "text-overflow") {=0A= e.style.textOverflow =3D value;=0A= }=0A= else if (name =3D=3D "text-transform") {=0A= e.style.textTransform =3D value;=0A= }=0A= else if (name =3D=3D "text-underline-position") {=0A= e.style.textUnderlinePosition =3D value;=0A= }=0A= else if (name =3D=3D "top") {=0A= e.style.top =3D value;=0A= }=0A= else if (name =3D=3D "unicode-bidi") {=0A= e.style.unicodeBidi =3D value;=0A= }=0A= else if (name =3D=3D "vertical-align") {=0A= e.style.verticalAlign =3D value;=0A= }=0A= else if (name =3D=3D "visibility") {=0A= e.style.visibility =3D value;=0A= }=0A= else if (name =3D=3D "white-space") {=0A= e.style.whiteSpace =3D value;=0A= }=0A= else if (name =3D=3D "width") {=0A= e.style.width =3D value;=0A= }=0A= else if (name =3D=3D "word-break") {=0A= e.style.wordBreak =3D value;=0A= }=0A= else if (name =3D=3D "word-spacing") {=0A= e.style.wordSpacing =3D value;=0A= }=0A= else if (name =3D=3D "word-wrap") {=0A= e.style.wordWrap =3D value;=0A= }=0A= else if (name =3D=3D "writing-mode") {=0A= e.style.writingMode =3D value;=0A= }=0A= else if (name =3D=3D "z-index") {=0A= e.style.zIndex =3D value;=0A= }=0A= else if (name =3D=3D "zoom") {=0A= e.style.zoom =3D value;=0A= }=0A= }=0A= catch (e) {=0A= /* ignore error on attempt to set e.style.[property] */=0A= }=0A= }=0A= }=0A= }=0A= ------=_NextPart_000_00DF_01C8F646.47BE8130 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://mcr.aacrjournals.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. For now we have to disable=0A= * the callback until we can track down a proper fix=0A= * (or everybody sanely upgrades to version 6 or 7!).=0A= */=0A= if (navigator) {=0A= var appname =3D navigator.appName;=0A= if (appname =3D=3D "Microsoft Internet Explorer") {=0A= var userAgent =3D navigator["userAgent"];=0A= var s =3D "MSIE ";=0A= var n =3D -1; =0A= if ((n =3D userAgent.indexOf(s)) !=3D -1) {=0A= var v =3D parseFloat(userAgent.substring(n+s.length));=0A= if (v < 6) {=0A= return;=0A= }=0A= }=0A= }=0A= }=0A= =0A= /*=0A= * Acquire table row element to update, initiate callback=0A= * to update table with Entrez Links.=0A= */=0A= var tr =3D document.getElementById('entrez_callback_'+pmid);=0A= if (!tr) {=0A= return;=0A= }=0A= var req =3D new XMLHttpRequest();=0A= if (!req) {=0A= return;=0A= }=0A= req.onreadystatechange =3D function() {=0A= if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || req.status = =3D=3D 304)) {=0A= var src =3D req.responseXML.documentElement;=0A= var dst =3D document.createDocumentFragment();=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], dst);=0A= }=0A= var tbl =3D tr.parentNode;=0A= tbl.replaceChild(dst, tr);=0A= }=0A= }=0A= req.open('GET', callback_url, true);=0A= req.send(null);=0A= }=0A= ------=_NextPart_000_00DF_01C8F646.47BE8130 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.google-analytics.com/urchin.js //-- Google Analytics Urchin Module=0A= //-- Copyright 2007 Google, All Rights Reserved.=0A= =0A= //-- Urchin On Demand Settings ONLY=0A= var _uacct=3D""; // set up the Urchin Account=0A= var _userv=3D1; // service mode (0=3Dlocal,1=3Dremote,2=3Dboth)=0A= =0A= //-- UTM User Settings=0A= var _ufsc=3D1; // set client info flag (1=3Don|0=3Doff)=0A= var _udn=3D"auto"; // (auto|none|domain) set the domain name for cookies=0A= var _uhash=3D"on"; // (on|off) unique domain hash for cookies=0A= var _utimeout=3D"1800"; // set the inactive session timeout in seconds=0A= var _ugifpath=3D"/__utm.gif"; // set the web path to the __utm.gif file=0A= var _utsp=3D"|"; // transaction field separator=0A= var _uflash=3D1; // set flash version detect option (1=3Don|0=3Doff)=0A= var _utitle=3D1; // set the document title detect option = (1=3Don|0=3Doff)=0A= var _ulink=3D0; // enable linker functionality (1=3Don|0=3Doff)=0A= var _uanchor=3D0; // enable use of anchors for campaign = (1=3Don|0=3Doff)=0A= var _utcp=3D"/"; // the cookie path for tracking=0A= var _usample=3D100; // The sampling % of visitors to track (1-100).=0A= =0A= //-- UTM Campaign Tracking Settings=0A= var _uctm=3D1; // set campaign tracking module (1=3Don|0=3Doff)=0A= var _ucto=3D"15768000"; // set timeout in seconds (6 month default)=0A= var _uccn=3D"utm_campaign"; // name=0A= var _ucmd=3D"utm_medium"; // medium (cpc|cpm|link|email|organic)=0A= var _ucsr=3D"utm_source"; // source=0A= var _uctr=3D"utm_term"; // term/keyword=0A= var _ucct=3D"utm_content"; // content=0A= var _ucid=3D"utm_id"; // id number=0A= var _ucno=3D"utm_nooverride"; // don't override=0A= =0A= //-- Auto/Organic Sources and Keywords=0A= var _uOsr=3Dnew Array();=0A= var _uOkw=3Dnew Array();=0A= _uOsr[0]=3D"google"; _uOkw[0]=3D"q";=0A= _uOsr[1]=3D"yahoo"; _uOkw[1]=3D"p";=0A= _uOsr[2]=3D"msn"; _uOkw[2]=3D"q";=0A= _uOsr[3]=3D"aol"; _uOkw[3]=3D"query";=0A= _uOsr[4]=3D"aol"; _uOkw[4]=3D"encquery";=0A= _uOsr[5]=3D"lycos"; _uOkw[5]=3D"query";=0A= _uOsr[6]=3D"ask"; _uOkw[6]=3D"q";=0A= _uOsr[7]=3D"altavista"; _uOkw[7]=3D"q";=0A= _uOsr[8]=3D"netscape"; _uOkw[8]=3D"query";=0A= _uOsr[9]=3D"cnn"; _uOkw[9]=3D"query";=0A= _uOsr[10]=3D"looksmart"; _uOkw[10]=3D"qt";=0A= _uOsr[11]=3D"about"; _uOkw[11]=3D"terms";=0A= _uOsr[12]=3D"mamma"; _uOkw[12]=3D"query";=0A= _uOsr[13]=3D"alltheweb"; _uOkw[13]=3D"q";=0A= _uOsr[14]=3D"gigablast"; _uOkw[14]=3D"q";=0A= _uOsr[15]=3D"voila"; _uOkw[15]=3D"rdata";=0A= _uOsr[16]=3D"virgilio"; _uOkw[16]=3D"qs";=0A= _uOsr[17]=3D"live"; _uOkw[17]=3D"q";=0A= _uOsr[18]=3D"baidu"; _uOkw[18]=3D"wd";=0A= _uOsr[19]=3D"alice"; _uOkw[19]=3D"qs";=0A= _uOsr[20]=3D"yandex"; 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