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{=0A= document.writeln('

3D"Click

');=0A= }=0A= =0A= function get_text_link(url, linktext)=0A= {=0A= document.writeln('' + = linktext + '');=0A= }=0A= =0A= function get_htmlftext_link(a, b) {=0A= document.writeln("" + = b + ", ");=0A= }=0A= =0A= ------=_NextPart_000_0000_01CA3E00.8BAB1E50 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/personalisation.js /*=0A= * Project : Interscience Redesign=0A= * File : personalisation.js=0A= * Creation Date : 25th March 2003=0A= * Author : Jonathan Sugar=0A= *=0A= * Various functions to deliver personalisation functionality.=0A= */=0A= =0A= // Pre-declare userName so it's available when we need to test if the = page=0A= // assembler ran OK=0A= var userName =3D null;=0A= var shcrtCookie =3D null;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Factory Methods=0A= =0A= // Simple wraper object to encapsulate the data for a co-branding item.=0A= function coBrandingItem(image, imageAltText, href)=0A= {=0A= //alert("Making new coBrandingItem:\nImage: " + image + = "\nimageAltText" + imageAltText + "\nhref: " + href);=0A= this.image =3D image;=0A= this.imageAltText =3D imageAltText;=0A= this.href =3D href;=0A= }=0A= =0A= /*=0A= * Insert the 'Customer co-branding' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert customer co branding. Loop through 'customerCoBranding' array=0A= * inserting XHTML where needed.=0A= *=0A= * NOTE: the array contains ONLY the resource location (the location of a = gif=0A= * on the file system), the required XHTML is then added where needed. = This way=0A= * we maintain the seperation between presentation and content.=0A= */=0A= function insertCustomerCoBranding(maxBranding)=0A= {=0A= if( customerCoBranding[0].image !=3D "none")=0A= {=0A= document.writeln('

');=0A= document.writeln('

');=0A= document.writeln('

' + imageAltText + '
' + imageAltText + = '
More Providers

');=0A= document.writeln('

');=0A= document.writeln('

3D""

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the 'My Area' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= *=0A= * My profile link absolute as this file isnt only run from w3 anymore.=0A= */=0A= function insertMyArea(userdata)=0A= {=0A= // just in case the page assembler isn't running.=0A= =0A= =0A= if (userName !=3D null)=0A= {=0A= document.writeln("

" + = userName.substring(0,33) + "..., access your
" + userName + = ", access your

My Profile"); =0A= } =0A= document.writeln(getLoginOutLink());=0A= //CR 3652 getAthenStatus() as added=0A= document.writeln(getAthenStatus());=0A= document.writeln("

");=0A= } else {=0A= if(typeof(environment)!=3D'undefined' && = environment=3D=3D'PRODUCTION') {=0A= document.writeln("

Log Out");=0A= document.writeln("

"); =0A= }=0A= }=0A= if (menuloadedflag){=0A= wisMenu();=0A= }=0A= }=0A= =0A= /*=0A= * Insert the Customer Admin 'Login/Logout' link=0A= * -----------------------------=0A= *=0A= * Author: Bobby Jack, December 2004.=0A= *=0A= */=0A= function insertAdminLink(page)=0A= {=0A= val =3D getCookie("AID");=0A= =0A= if (val && val !=3D "-1")=0A= {=0A= document.writeln('

Logout');=0A= }=0A= else=0A= {=0A= document.writeln('

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the username section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert the username.=0A= */=0A= function insertUserName()=0A= {=0A= document.write(userName);=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the login/logout cgi=0A= * ---------------------------------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= * Had to change the links absolute as this file isnt only run from w3 = anymore.=0A= */=0A= function getLoginOutLink()=0A= {=0A= if(userName !=3D "")=0A= {=0A= return "

";=0A= }else=0A= {=0A= return "

";=0A= }=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the shopping cart content page=0A= * ---------------------------------------------------=0A= *=0A= * Author: Zhiming & Warrell June 2007=0A= */=0A= function getShCrtLink(logged)=0A= {=0A= if(logged =3D=3D true )=0A= return "

";=0A= else=0A= return "

";=0A= }=0A= =0A= function toggleShCrtLink()=0A= {=0A= shcrtCookie =3D readCookie("SHCRT");=0A= if(shcrtCookie !=3D null)=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "block";=0A= }=0A= }=0A= else=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "none";=0A= }=0A= }=0A= }=0A= =0A= =0A= =0A= function readCookie(name)=0A= {=0A= var nameEQ =3D name + "=3D";=0A= var ca =3D document.cookie.split(';');=0A= for(var i=3D0; iYou are logged in = to Athens';=0A= }=0A= else=0A= {=0A= return "

";=0A= }=0A= =0A= } ------=_NextPart_000_0000_01CA3E00.8BAB1E50 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/site.js /************************************************************************= ***************************=0A= FILE: site.js=0A= AUTHOR: Jonathan Sugar, Chris Neatby-Smith and Digital Pulp. July = 2003.=0A= =0A= DESCRIPTION: Javascript relating to site wide functionality across =0A= InterScience.=0A= =0A= INCLUDES FUNCTIONS=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Search Functions=0A= ----------------=0A= =0A= selectAndSubmit() - for deciding where to submit a query based on the = state of the form.=0A= processallContentSearch() - for validating form input for an all = content search.=0A= processTitleSearch() - for validating form input for a Title search.=0A= checkCitationSearch() - for validating the citation search form.=0A= selectAll() - check all the checkboxes in a form.=0A= do_popup() - stasa Acronym Finder window popup function.=0A= =0A= =0A= Other Functions=0A= ---------------=0A= =0A= fixInlineLists() - fix netscape 4.x bug where

tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract | References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if ((isNaN(parseInt(itemID))=3D=3Dtrue)||(arguments.length >=3D 4 && = arguments[3] =3D=3D 'cluster'))=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= //check whether the last 2 arguments is used for urllink.=0A= // urllink is needed to open up mail form for mrw pages on tomcat = port=0A= if (arguments.length>=3D5 && = arguments[arguments.length-2]=3D=3D'urllink' && = arguments[arguments.length-1]!=3D'')=0A= {=0A= url =3D arguments[arguments.length-1] + url;=0A= }=0A= =0A= if (arguments.length>=3D5 && arguments[3]=3D=3D'currentlink' && = arguments[4]!=3D'')=0A= {=0A= url =3D url + '¤tLink=3D' + arguments[4];=0A= =0A= //processing specific cases=0A= if (arguments[4]=3D=3D'jcatalogjsphdr')=0A= {=0A= //get the issn and pass it the next stage for processing=0A= var currloc =3D location.href;=0A= var issnloc =3D currloc.indexOf("&issn=3D");=0A= if (issnloc !=3D -1)=0A= {=0A= url =3D url + '¤tISSN=3D' + = currloc.substring(issnloc+6);=0A= }=0A= }=0A= // issn is needed for cocoon rendered mrw to form the final url.=0A= else if ( (arguments[4]=3D=3D'cocoonmrwhome') || = (arguments[4]=3D=3D'cocoonmrwarticle') )=0A= {=0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'issn' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tISSN=3D' + arguments[6];=0A= }=0A= //getting the parameters of the currently shown mrw from the = url=0A= //the method used here is a little crude, it extracts the = values from the current url of the page the user is in =0A= //to pass it to the background program to reconstruct the = requred url=0A= if (arguments[4]=3D=3D'cocoonmrwhome')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= var mrwFileParam =3D mrwParamArr[6];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= mrwFileParam =3D = mrwFileParam.substring(0,seploc);=0A= }=0A= seploc =3D mrwFileParam.indexOf("?");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwUrlParam=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= =0A= }=0A= else if (arguments[4]=3D=3D'cocoonmrwarticle')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= url =3D url + '&mrwAid=3D' + mrwParamArr[7];=0A= url =3D url + '&mrwVersion=3D' + mrwParamArr[8];=0A= var mrwFileParam =3D mrwParamArr[9];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= }=0A= }=0A= }=0A= =0A= //checking if a html file exists in the url=0A= var tmpfname =3D location.href;=0A= var loc =3D tmpfname.indexOf("?");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(0,loc);=0A= }=0A= loc =3D tmpfname.indexOf(".html");=0A= if (loc !=3D -1)=0A= {=0A= loc =3D tmpfname.lastIndexOf("/");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(loc+1);=0A= url =3D url + '¤tFile=3D' + tmpfname;=0A= }=0A= }=0A= =0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'currentyear' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tYear=3D' + arguments[6];=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln(' 3D"blank"

');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln(' 3D"blank"

'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x" + = liels[j].innerHTML + "

You do not have = anything saved in this menu.

";=0A= else=0A= tmpinnerhtml +=3D "

" = + liels[j].innerHTML + "

"; =0A= } =0A= } else {=0A= //setup var to see if more is required=0A= var more =3D (subnodeslength < lilength) ? true : = false; =0A= var flag =3D true;=0A= for (var j=3D0; j" + liels[j].innerHTML + = "";=0A= } else if (j > lilength-3){=0A= if (j =3D=3D lilength-2){=0A= var url =3D liels[j].innerHTML.split('"')[1];=0A= tmpinnerhtml +=3D "

" + liels[j].innerHTML + "

";=0A= } else {=0A= tmpinnerhtml +=3D "

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Brain Pathology

ISSN: 1750-3639 (Online)

ISSN: 1015-6305 (Print)

Volume 17, Issue 3, 2007.

Pages: 314=96318

Top of Page
Abstract
PAPILLARY TUMOR OF THE PINEAL REGION
SPINDLE CELL ONCOCYTOMA
References

List of=20 Images

Abstract=20 Only

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tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. 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Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract | References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if ((isNaN(parseInt(itemID))=3D=3Dtrue)||(arguments.length >=3D 4 && = arguments[3] =3D=3D 'cluster'))=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= //check whether the last 2 arguments is used for urllink.=0A= // urllink is needed to open up mail form for mrw pages on tomcat = port=0A= if (arguments.length>=3D5 && = arguments[arguments.length-2]=3D=3D'urllink' && = arguments[arguments.length-1]!=3D'')=0A= {=0A= url =3D arguments[arguments.length-1] + url;=0A= }=0A= =0A= if (arguments.length>=3D5 && arguments[3]=3D=3D'currentlink' && = arguments[4]!=3D'')=0A= {=0A= url =3D url + '¤tLink=3D' + arguments[4];=0A= =0A= //processing specific cases=0A= if (arguments[4]=3D=3D'jcatalogjsphdr')=0A= {=0A= //get the issn and pass it the next stage for processing=0A= var currloc =3D location.href;=0A= var issnloc =3D currloc.indexOf("&issn=3D");=0A= if (issnloc !=3D -1)=0A= {=0A= url =3D url + '¤tISSN=3D' + = currloc.substring(issnloc+6);=0A= }=0A= }=0A= // issn is needed for cocoon rendered mrw to form the final url.=0A= else if ( (arguments[4]=3D=3D'cocoonmrwhome') || = (arguments[4]=3D=3D'cocoonmrwarticle') )=0A= {=0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'issn' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tISSN=3D' + arguments[6];=0A= }=0A= //getting the parameters of the currently shown mrw from the = url=0A= //the method used here is a little crude, it extracts the = values from the current url of the page the user is in =0A= //to pass it to the background program to reconstruct the = requred url=0A= if (arguments[4]=3D=3D'cocoonmrwhome')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= var mrwFileParam =3D mrwParamArr[6];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= mrwFileParam =3D = mrwFileParam.substring(0,seploc);=0A= }=0A= seploc =3D mrwFileParam.indexOf("?");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwUrlParam=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= =0A= }=0A= else if (arguments[4]=3D=3D'cocoonmrwarticle')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= url =3D url + '&mrwAid=3D' + mrwParamArr[7];=0A= url =3D url + '&mrwVersion=3D' + mrwParamArr[8];=0A= var mrwFileParam =3D mrwParamArr[9];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= }=0A= }=0A= }=0A= =0A= //checking if a html file exists in the url=0A= var tmpfname =3D location.href;=0A= var loc =3D tmpfname.indexOf("?");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(0,loc);=0A= }=0A= loc =3D tmpfname.indexOf(".html");=0A= if (loc !=3D -1)=0A= {=0A= loc =3D tmpfname.lastIndexOf("/");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(loc+1);=0A= url =3D url + '¤tFile=3D' + tmpfname;=0A= }=0A= }=0A= =0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'currentyear' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tYear=3D' + arguments[6];=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln(' 3D"blank"

');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln(' 3D"blank"

'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x=3D 0) { appname =3D "ns"; }=0A= else if (navigator.appName.indexOf("Explorer") >=3D 0) { appname =3D = "ie"; }=0A= if (navigator.userAgent.indexOf("Mozilla/2") >=3D 0) {=0A= version =3D 2;=0A= } else if (navigator.userAgent.indexOf("Mozilla/3") >=3D 0) {=0A= version =3D 3;=0A= } else if (navigator.userAgent.indexOf("Mozilla/4") >=3D 0) {=0A= version =3D 4;=0A= } else if (navigator.userAgent.indexOf("Mozilla/5") >=3D 0) {=0A= version =3D 5;=0A= }=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Get the cookies named "REF_LNX and SRC_LNX"... deprecated for now. = Always set.=0A= // Instead set the hypertext for linking.=0A= //var anchorString =3D ' 3D"extended

3D"extended

';=0A= var anchorString =3D 'Links';=0A= var targString =3D ' target=3D_top';=0A= var anchor2 =3D 'links';=0A= =0A= //NEW for special content linking. Anchor string must be taken from SGML.=0A= var contAnchor =3D '';=0A= =0A= // Linking functions=0A= =0A= =0A= //Get the EarlyView flag of the citing article which is needed to ensure = that the link is suitable for ISI WoS.=0A= // The CONTROL details are passed in, in the form -----. only grab the = 2nd of 5 characters which is the EarlyView flag=0A= function setEarlyView(object)=0A= {=0A= if ((version >=3D 3) && (object.substring(1,2) !=3D "Y"))=0A= {=0A= artEarlyView =3D "EVIEW=3DN"; =0A= }=0A= }=0A= =0A= //Get the DOI of the citing article which is needed for the ISI links.=0A= function setDOI(object){=0A= if (version >=3D 3)=0A= {=0A= artDOI =3D object;=0A= }=0A= }=0A= =0A= function setISSN(object)=0A= {=0A= }=0A= =0A= // Print out the reference link. =0A= function print_link(object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= // remove over-escaped ampersands (ref bugzilla 5515)=0A= var overEscapedAmpersandsRemoved =3D object.replace(new = RegExp('&','g'), '&');=0A= =0A= // remove "BIB" prefix from the value of BIBID (for ISI linking)=0A= // note, this could be performed in LNX. Need to reassess where this = should be done.=0A= var re =3D new RegExp ('BIBID=3DBIB', 'i') ;=0A= var paramstring =3D new String();=0A= paramstring =3D overEscapedAmpersandsRemoved.replace(re, 'BIBID=3D');=0A= =0A= var unpCookie =3D '/cgi-bin/reflink?object=3D' + escape(paramstring = + "&" + artDOI + "&" + artEarlyView + "&" + artEnableISI + "&" + = artTurnOnCas + "&" + artEnablePubMed);=0A= if (netscape4 =3D=3D false)=0A= {=0A= document.write ('' + anchorString + ' ');=0A= }=0A= else // protect against inline style application hanging NN4=0A= {=0A= document.write ('' + = anchorString + ' '); =0A= }=0A= }=0A= else=0A= {=0A= document.writeln();=0A= } =0A= }=0A= =0A= //Print out source links (in the citing article)=0A= function print_SRClink(object){=0A= if (version >=3D 3)=0A= {=0A= var unpCookie =3D '/cgi-bin/srclink?object=3D' + escape(object);=0A= var url =3D unpCookie;=0A= document.write ('

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return hwnd; } =0A= function pagetitle() {return 'Brain Pathology Vol. 17, 3 Pages: = 314-318'; } =0A= function dochead(hwnd, spec) {var title =3D pagetitle(); = hwnd.document.open(); = hwnd.document.write(''+spec+title+''); } =0A= function doctail(hwnd) {hwnd.document.write(''); } =0A= function pagehead(hwnd) {hwnd.document.write('

3D"About

Online ISSN: = 1096-9896 Print ISSN: 0022-3417
The Journal of = Pathology
Volume 214, Issue 3, 2008. Pages: 328-336

Copyright =C2=A9 2007 Pathological Society of Great = Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Copyright Journal Compilation = © 2007 International Society of Neuropathology

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'); } =0A= =0A= =0A= function caption_f1(hwnd) = {hwnd.document.write('Figure 1. Papillary tumor of the = pineal region (PTPR). PTPR exhibits a characteristic papillary = architecture (A,B). At higher power (B), a = pseudostratified columnar arrangement around vessels is seen. Also = characteristic are areas of solid tumor, shown here at low (C) = and high (D) power. (All panels, H&E)'); }=0A= function display_f1(size) { var i =3D new Array(); i[0] =3D 'nf1'; i[1] = =3D 'nf1'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f1', size); imagelink(hwnd, i[size]); = caption_f1(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= function caption_f2(hwnd) = {hwnd.document.write('Figure 2. Papillary tumor of the = pineal region. Characteristic papillary tumor of the pineal region = expression patterns are illustrated for CAM5.2 (A), S-100 protein = (B), vimentin (C), and glial fibrillary acidic protein = (D).'); }=0A= function display_f2(size) { var i =3D new Array(); i[0] =3D 'nf2'; i[1] = =3D 'nf2'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f2', size); imagelink(hwnd, i[size]); = caption_f2(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= function caption_f3(hwnd) = {hwnd.document.write('Figure 3. Spindle cell = oncocytoma. These tumors typically consist of interwoven fascicles of = spindled cells and, to a lesser extent, epithelioid cells (A) = that exhibit finely granular eosinophilic cytoplasm and mild-to-moderate = nuclear atypia (B). Marked nuclear hyperchromasia and = pleomorphism may be seen (C), and focal myxoid changes may be = present in some tumors (D).'); }=0A= function display_f3(size) { var i =3D new Array(); i[0] =3D 'nf3'; i[1] = =3D 'nf3'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f3', size); imagelink(hwnd, i[size]); = caption_f3(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= function caption_f4(hwnd) = {hwnd.document.write('Figure 4. Spindle cell = oncocytoma. Spindle cell oncocytomas are characterised by = immunoreactivity for S-100 protein (A), EMA (B), and = galectin-3 (C).'); }=0A= function display_f4(size) { var i =3D new Array(); i[0] =3D 'nf4'; i[1] = =3D 'nf4'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f4', size); imagelink(hwnd, i[size]); = caption_f4(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= =0A= =0A= function imagelist() {var hwnd =3D newfigwin(); dochead(hwnd, 'List of = Images - '); copyright(hwnd); =0A= hwnd.document.write('');=0A= =0A= =0A= hwnd.document.write('');=0A= hwnd.document.write('');=0A= hwnd.document.write('');=0A= hwnd.document.write('');hwnd.document.write('

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Brain Pathology

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Volume 17, Issue 3, Pages 314-318

Published Online: 26 Jun 2007

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3D""=20

SYMPOSIUM: The 2007 Revised World = Health=20 Organization (WHO) Classification of Tumours of the Central = Nervous=20 System: Newly Codified Entities

Papillary Tumor of the Pineal Region = and Spindle=20 Cell Oncocytoma of the Pituitary: New Tumor Entities in the 2007 = WHO=20 Classification

Federico Roncaroli=20 ¹ ; Bernd W. Scheithauer=20 ²

¹ University = Department=20 of Neuropathology, Imperial College, London, UK.
² Department of = Laboratory Medicine and Pathology, Mayo Clinic, Rochester, = MN.=20

Correspondence to Bernd = W. Scheithauer,=20 MD, Department of Laboratory Medicine and Pathology, Mayo Clinic, = 200=20 First Street SW, Rochester, MN 55905 (E-mail: scheithauer.bernd@mayo.edu= )=20

Copyright Journal Compilation =A9 2007 = International Society of Neuropathology

ABSTRACT

3DAbstract=20

We have reviewed the features of two recently = described=20 intracranial tumors, which have been formally recognized as = distinct=20 entities by the 2007 WHO Classification of Brain Tumours: = Papillary tumor=20 of the pineal region and spindle cell oncocytoma of the pituitary = gland.=20 Their salient clinicopathological features, differential = diagnosis,=20 histogenetic hypothesis and outcome are discussed.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1750-3639.2007.00081.x About=20 DOI

=20

=20

=20

PAPILLARY TUMOR OF THE PINEAL = REGION

=20

Definition and general=20 features. Described as a distinct entity in 2003 by = Jouvet=20 et al (12),=20 papillary tumor of the pineal region (PTPR) has been formally = codified in=20 the 2007 edition of the World Health Organization (WHO) = Classification of=20 Tumours of the Central Nervous System (13),=20 and assigned a provisional ICD-O code of 9395/3. To date, only 41 = examples=20 have been documented; however, communication with = neuropathologists at=20 referral centers across the world confirms the existence of = additional,=20 unreported, examples. Moreover, it is clear that tumors with = identical=20 histology and clinicopathologic features as those of PTPR have = previously=20 been reported under various other names, including papillary = pineocytoma,=20 pineal parenchymal tumor, choroid plexus tumor, ependymoma and = papillary=20 meningioma. In addition, it is highly likely that additional = unrecognized=20 examples have been given a diagnosis of metastatic papillary = carcinoma of=20 unknown primary origin. The clinicopathologic features of PTPR = have=20 recently been reviewed by Fevre-Montange et al (6)=20 and by Dagnew et al (3).=20 PTPR arises exclusively in the pineal region and occurs most = commonly in=20 adults, although the age at presentation ranges from 5 to 66 years = (mean,=20 31.5 years). There is a slight predominance of females. Headache, = usually=20 of short duration, is the most common presenting symptom and = occurs=20 secondary to hydrocephalus resulting from compression of the = cerebral=20 aqueduct. PTPRs are usually well-circumscribed, large = (2.5=964.0 cm)=20 mass lesions that sometimes feature a cystic component. On = computerized=20 tomographic (CT) imaging, they are hypodense and = contrast-enhancing.=20 Magnetic resonance imaging (MRI) shows hyperintensity on = T2-weighted=20 images and enhancement on T1-weighted sequences following = gadolinium=20 administration.

=20

Histological and = immunohistochemical=20 features. Papillary tumors of the pineal region=20 characteristically show a discrete, compressive border with = adjacent=20 pineal gland and brain parenchyma. As the name indicates, a = salient=20 histological hallmark is papillary architecture (Figure 1A,B).=20 The degree of papillary formation varies from case to case, with = the other=20 major architectural motif being solid cellular sheets of tumor = cells (Figure 1C,D).=20 The latter areas variably feature pseudorosettes, true rosettes, = and/or=20 tubules with small lumina. In the papillary component, vessels are = often=20 hyalinized and are covered by large, pale-to-eosinophilic cells = arranged=20 in a pseudostratified columnar layering (Figure 1B).=20 In the solid cellular areas, tumor cells show clear or vacuolated=20 cytoplasm (Figure 1D).=20 Less commonly, eosinophilic and PAS-positive cytoplasmic = inclusions are=20 encountered. As a rule, nuclei are regular, round-to-oval and = contain=20 stippled chromatin, although pleomorphic nuclei may be seen in = some cases.=20 Mitotic activity varies, ranging from 0 to 10 mitoses per 10 high = power=20 (=D740) fields. Necrosis is usually found to some extent in most = tumors. In=20 contrast, vascular proliferation is consistently absent, although = slight=20 endothelial hyperplasia may be seen in some vessels. Recurrent = tumors=20 exhibit the same morphologic features as seen in the respective = primary=20 tumor, with the papillary component often becoming more = prominent.

=20

= Figure 1. Papillary tumor = of the=20 pineal region (PTPR). PTPR exhibits a characteristic = papillary=20 architecture (A,B). At higher power = (B), a pseudostratified columnar arrangement = around=20 vessels is seen. Also characteristic are areas of solid = tumor, shown=20 here at low (C) and high (D) power. (All panels, H&E)=20

[Normal View=20 ]

The immunophenotype of PTPR has been extensively=20 investigated (6).=20 The most distinctive feature is immunoreactivity for a broad = spectrum of=20 cytokeratins, including KL1, AE1/AE3, CAM5.2 and cytokeratin 18, = which is=20 more evident in the papillary than in the solid component (Figure 2A).=20 In particular, cytokeratin 18 expression is a constant finding and = is=20 always intense. Although examined in only a minority of cases, no = CK20=20 staining has been reported, and only weak, focal staining and has = been=20 reported for CK7 and CK5/6. Epithelial membrane antigen (EMA) = expression=20 is seen in the majority of tumors, but is restricted to the cell = surface,=20 particularly that abutting vessels. Dot-like staining similar to = that seen=20 in ependymoma may also be seen (12,=20 16, 20). In addition to epithelial marker staining, PTPRs have = also=20 been reported to express vimentin, S-100 protein, NSE, MAP2, N-CAM = and=20 transthyretin (10,=20 20). Cytoplasmic and often nuclear expression of S100 protein = is=20 present in nearly all tumor cells, and vimentin typically stains = tumor=20 cell cytoplasm adjacent to vessel walls (Figure 2B,C).=20 Reactivity for glial fibrillary acidic protein (GFAP) has been = reported in=20 approximately 12% of tumors, but expression of this marker is = typically=20 restricted to focal perivascular areas at the tumour (Figure 2D).=20 Synaptophysin and chromogranin reactivity may be seen, but only = weakly and=20 focally (12).=20 No immunolabeling for neurofilament proteins has been reported. = Focal=20 transthyretin staining has been reported in approximately half of = tumors=20 tested and has also been observed in normal peritumoral pineal = cells.=20 Expression of the adhesion molecules NCAM and E-cadherin has been = examined=20 in only two tumors; the former was present in both lesions, = particularly=20 on surface membranes, whereas no E-cadherin reactivity was = observed. The=20 same two tumors also expressed nestin. The majority of PTPR are=20 characterized by lack of membrane staining for Kir7.1 and lack of=20 cytoplasmic reactivity for stanniocalcin-1, both of which are seen = in=20 choroid plexus tumors (10).=20 The MIB-1 (Ki-67 antigen) labeling index ranges from less than 5% = to=20 greater than 10%, with indices being higher in young = patients.

=20

= Figure 2. Papillary tumor = of the=20 pineal region. Characteristic papillary tumor of the pineal = region=20 expression patterns are illustrated for CAM5.2 (A), S-100 protein (B), vimentin=20 (C), and glial fibrillary acidic = protein (D).

[Normal View=20 ]

=20

Differential=20 diagnosis. The differential diagnosis of PTPR is broad = and=20 includes all pineal region lesions known to exhibit papillary = architecture=20 (3,=20 6). These include the pineal parenchymal tumors, papillary = ependymoma,=20 choroid plexus tumors, papillary meningioma and metastases. Unlike = PTPR,=20 pineal parenchymal tumors show strong immunoexpression of neuronal = markers. Distinction of PTPR from metastatic papillary carcinomas = of=20 unknown primary can be challenging and is primarily based on the = very low=20 or absent expression of CK7/CK20 and low MIB-1 labeling indices = that are=20 characteristic of PTPR. Nestin expression may also aid diagnosis = in that=20 it is usually absent in metastatic carcinoma. The distinction from = choroid=20 plexus tumors may also be difficult if based upon = immunohistochemical=20 findings alone. Both PTPR and choroid plexus papilloma express=20 cytokeratins and transthyretin; however, most PTPRs show MAP-2 = staining=20 and do not express Kir7.1, which is a marker for choroid plexus = tumors (6).=20 The distinction of PTPR from ependymoma can be problematic in that = the=20 former often shows immunohistochemical and ultrastructural = features of=20 ependymal differentiation. The relatively lesser degree of GFAP = expression=20 seen in PTPR is of marginal utility, and the presence of neuronal = features=20 at the immunohistochemical and ultrastructural levels (14)=20 is of limited value because ependymomas may also exhibit neuronal=20 differentiation (18).=20 Papillary meningioma can usually be excluded by virtue of a = general lack=20 of cytokeratin expression.

=20

Histogenesis. The=20 histogenesis of PTPR remains to be confirmed, although it is = likely that=20 these distinctive tumors originate from remnants of specialized = ependymal=20 cells of the subcommissural organ (12),=20 which is present in humans during embryologic development and = persists in=20 vestigial form in adults (8).=20 Support for this notion comes from the expression of nestin and=20 cytokeratin 18, as well as from DNA microarray analyses, which = have shown=20 high expression of the genes ZFH4, RFX3, TTR and CGRP, all of = which are=20 expressed by the subcommissural organ (5).=20 The subcommissural organ is a member of the highly specialized=20 circumventricular organ (CVO) group, which also includes the = subfornical=20 organ and the organum vasculosum of the lamina terminalis. The = potential=20 significance of the specialized ependymal covering associated with = the=20 CVOs with respect to the origin of several rare types of CNS tumor = is=20 increasingly recognized (8,=20 17).

=20

Genetics. The = genetic=20 profile of PTPR has been investigated using comparative genomic=20 hybridization. Of five lesions examined, four showed chromosomal=20 imbalances, with the most common changes being loss of chromosomes = 10=20 (four cases) and 22q (three cases), as well as gain of chromosomes = 4 (four=20 cases), 8, 9 and 12 (three cases each) (10).

=20

Prognostic and predictive=20 factors. Papillary tumors of the pineal region are=20 characterized by frequent local recurrence but only occasional = spinal=20 dissemination. This prompted the WHO panel to suggest = correspondence to=20 grades II or III. Fevre-Montange et al (6)=20 reviewed the prognosis of PTRP. Detailed follow-up information was = obtained in 29 of 31 cases, with the mean follow-up period being = 4.2=20 years. Progression was seen in 72% of cases. Five-year estimates = of=20 overall and progression-free survival were 73% and 27%, = respectively.=20 Seven patients died of disease. The same authors also investigated = the=20 effect of age, gender, tumor size, gross total resection and = adjuvant=20 radiotherapy upon survival. Incomplete resection and a mitotic = index=20 higher than five per 10 high power fields (HPFs) seemed to = correlate with=20 decreased survival and recurrence (6),=20 whereas age less than 30 years was unassociated with risk of = progression=20 or death. On univariate analysis, gross total resection was the = only=20 clinical factor strongly associated with overall survival and = recurrence,=20 but statistical significance was not achieved. Fifteen patients = had=20 received radiotherapy, nine after complete and six after = incomplete=20 resection; however, the therapeutic regimens differed. The = observation=20 that MIB-1 labeling is higher in younger patients is of interest, = but this=20 parameter did not correlate with a less favorable outcome in this = age=20 group. Given the infrequent occurrence of PTPR, conclusions = regarding=20 behavior and optimal post-operative treatment await additional = experience=20 and prospective study.

=20

=20

SPINDLE CELL ONCOCYTOMA

=20

Definition and general=20 features. Spindle cell oncocytoma (SCO), which was = described=20 as a new entity by Roncaroli et al in 2002 (19),=20 is a non-adenomatous sellar region tumor that has been codified in = the=20 2007 WHO classification, in which it is defined as a=20 spindled-to-epithelioid, oncocytic, non-endocrine neoplasm of the = anterior=20 hypophysis that manifests in adults and follows a benign clinical = course=20 (9).=20 It corresponds to WHO grade I and has a provisional ICD-O code of = 8290/0.=20 SCO is an uncommon lesion of adults in the age range of 26=9671 = years (mean,=20 56 years). The actual incidence is difficult to determine, but in = one=20 single-institution experience, SCO accounted for approximately = 0.4% of all=20 operated sellar tumors (15).=20 Only 10 examples have been published to date (4,=20 15, 19, 22).

SCO originates in adenohypophyseal tissue, and = accordingly=20 may present as an intrasellar, suprasellar, or combined=20 intrasellar/suprasellar mass. In this regard, five of the10 = reported cases=20 presented as intrasellar masses with suprasellar extension, three = invaded=20 into the cavernous sinus (4,=20 22), and one invaded the sellar floor (15).=20 The clinical presentation of patients with SCO is = indistinguishable from=20 that of other non-hormone-producing sellar masses. Patients = reported so=20 far have exhibited primarily hypopituitarism and visual field = defects;=20 less frequently, headache, nausea and vomiting were present (4,=20 15, 19, 22). One of two reported patients with recurrent SCO = had=20 involvement of the skull base with epistaxis (15).=20 The neuroimaging findings of SCO are indistinguishable from those = of=20 pituitary macroadenoma, with MRI studies showing contrast = enhancement,=20 circumscribed growth pattern and solid appearance. Calcification = has not=20 been reported.

=20

Histopathological=20 features. Grossly, SCO is indistinguishable from = conventional=20 pituitary adenoma. The texture varies from soft, creamy and = amenable to=20 removal by ultrasonic aspiration, to firm and tenaciously adherent = to the=20 surrounding structures. Although the imaging appearance is well=20 circumscribed, a sharp margin with the surrounding pituitary = parenchyma is=20 usually absent.

Histologically, SCO is composed of compact, = interwoven=20 fascicles of spindled cells, with a variable admixture of = epithelioid=20 cells. Some tumors exhibit a vaguely lobular architecture. The = cytoplasm=20 is typically eosinophilic and finely granular (Figure 3A,B).=20 As a rule, nuclei are only mildly to moderately atypical, but = occasional=20 cells may show nuclear hyperchromasia and marked pleomorphism (Figure 3C).=20 Mitoses are usually rare-to-absent, although increased mitotic = activity=20 has been reported in one recurrent lesion (15).=20 Focal myxoid changes may be present (Figure 3D).=20 Many tumors display patchy infiltrates of mature = lymphocytes.

=20

= Figure 3. Spindle=20 cell oncocytoma. These tumors typically consist of = interwoven=20 fascicles of spindled cells and, to a lesser extent, = epithelioid=20 cells (A) that exhibit finely = granular=20 eosinophilic cytoplasm and mild-to-moderate nuclear atypia = (B). Marked nuclear hyperchromasia and = pleomorphism=20 may be seen (C), and focal myxoid = changes may=20 be present in some tumors (D). =

[Normal View=20 ]

SCOs have been investigated with a broad spectrum = of=20 antibodies. The typical immunophenotype includes expression of = vimentin,=20 S-100 protein (Figure 4A),=20 EMA (Figure 4B),=20 anti-mitochondrial antibody 113-1 and galectin-3 (Figure 4C).=20 In contrast, immunostains for pituitary hormones and other = antigens,=20 including synaptophysin, chromogranin, cytokeratins, GFAP, CD34, = bcl-2,=20 smooth muscle actin and desmin, are usually negative. Only one = case=20 reportedly showed expression of bcl-2 and GFAP in occasional cells = (22).=20 The MIB-1 labeling index of primary tumors has ranged from 1% to = 8% (mean,=20 2.8%). Indices as high as 18%=9620% have been seen in the reported = recurrences of two aggressive tumors (15).

=20

= Figure 4. Spindle=20 cell oncocytoma. Spindle cell oncocytomas are characterised = by=20 immunoreactivity for S-100 protein (A), EMA=20 (B), and galectin-3 (C).

[Normal View=20 ]

Ultrastructural study has been performed in eight = cases (4,=20 12, 15, 18), and has proved helpful in distinguishing SCO from = pituitary adenoma, in which the neoplastic cells of SCO are=20 characteristically filled with abnormal mitochondria and, with = rare=20 exceptions, display scant, well-formed desmosomes (15)=20 or junctions of intermediate type. In addition, in contrast to = pituitary=20 adenoma, all reported cases except one have lacked secretory = granules (4).

=20

Histogenesis. The origin=20 of SCO remains to be established. A derivation from the = folliculostellate=20 cell (FSC) of the anterior pituitary was postulated in the = original=20 description based upon similarities between the neoplastic cells = and=20 normal FSCs (19).=20 FSCs comprise a heterogeneous population of non-hormone-secreting = stellate=20 cells of the anterior pituitary that form a three-dimensional = network=20 surrounding the acini. They exert regulatory functions upon the=20 hormone-secreting cells, play a key role in intercellular = communication by=20 releasing signaling molecules and growth factors, and may function = as=20 antigen presenting cells (1).=20 S-100 protein is a reliable marker for human FSCs, and they are = also known=20 to express GFAP, vimentin, cytokeratin, galectin-3, MHC class II = antigen,=20 interleukins 6 and 10, annexin-1, follistatin, macrophage = inhibiting=20 factor and vascular endothelial growth factor in various = combinations,=20 supporting the concept that FSCs are functionally heterogeneous.=20 Ultrastructurally, FSCs form desmosomal junctions along their = lateral=20 borders between themselves and with glandular cells. In contrast,=20 cell-to-cell junctions are absent or rare between the cells of the = latter=20 population. Recent ultrastructural and immunohistochemical studies = of=20 normal and adenomatous human pituitary suggest that FSCs may = represent an=20 adult stem cell-progenitor population (11).

=20

Differential=20 diagnosis. The differential diagnosis of SCO is broad = and=20 includes oncocytic pituitary adenoma, granular cell tumor, = pituicytoma,=20 intrasellar schwannoma, meningioma with oncocytic change, solitary = fibrous=20 tumor and paraganglioma. Criteria for distinguishing SCO from = these tumors=20 have been extensively discussed (4,=20 15, 19, 22, 23); however, the differential diagnosis between = SCO and=20 pituicytoma warrants further mention. Like SCO, pituicytomas are = intensely=20 immunoreactive for vimentin and S-100 protein. Although the = majority of=20 pituicytomas exhibit reactivity for GFAP, the extent and intensity = of=20 expression is quite variable, with some examples being = immunonegative. In=20 addition, a few pituicytomas have shown focal EMA immunolabeling = (2,=20 21), although when present this is usually patchy and = cytoplasmic=20 rather than membranous. Ultrastructurally, SCO and pituicytoma = exhibit=20 some shared features. Brat et al (2)=20 described abundant cytoplasmic filaments and scattered = "intermediate"=20 junctions in pituicytoma. These authors also mentioned the = presence of=20 abundant mitochondria in the three tumors analyzed, and moderate=20 accumulation of mitochondria in pituicytoma was noted by = Figarella-Branger=20 et al (7).=20 However, the hallmark feature of SCO, oncocytic change, is not a=20 characteristic attribute of pituicytoma.

=20

Prognostic and predictive=20 factors. Overall, SCO is benign tumor with little = tendency to=20 recur, even after incomplete excision. Updated follow-up of the = five=20 originally reported cases found no recurrence (follow-up range, = 6=9611=20 years; mean 7.8 years). Combining these data with the reported = follow-up=20 of other cases, eight patients were alive and well after follow-up = ranging=20 from 6 to 16 years (mean, 7.8 years), and two experienced = recurrence=20 within 3 years of initial surgery. Of these, one patient was = clinically=20 stable for 8 years and then became symptomatic because of optic = chiasm=20 compression (4).=20 The other patient experienced an aggressive second recurrence, = with=20 destruction of the clivus, sphenoid sinus and ethmoid sinus, as = well as=20 nasopharyngeal and nasal cavity extension (15).=20 In both patients, the primary tumors showed no features that were=20 predictive of aggressive behavior. Both of the recurrent tumors = exhibited=20 high MIB-1 labeling indices (18% and 20%).

=20

Treatment. Surgery is the=20 treatment of choice for SCO, with small size and lack of invasion = being=20 factors that favor gross total resection. When this cannot be = achieved,=20 radiation therapy might be considered. The role of radiation = therapy has=20 been discussed by Dahiya et al (4);=20 one of their two patients received proton beam irradiation and was = recurrence-free after 7 years. However, experience is very limited = and=20 long-term follow-up of additional cases is needed to determine the = significance of potential prognostic factors such as invasion and=20 proliferation activity.

=20

=20

=20

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