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{=0A= document.writeln('

3D"Click

');=0A= }=0A= =0A= function get_text_link(url, linktext)=0A= {=0A= document.writeln('' + = linktext + '');=0A= }=0A= =0A= function get_htmlftext_link(a, b) {=0A= document.writeln("" + = b + ", ");=0A= }=0A= =0A= ------=_NextPart_000_0000_01CA3E03.5054A8F0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/personalisation.js /*=0A= * Project : Interscience Redesign=0A= * File : personalisation.js=0A= * Creation Date : 25th March 2003=0A= * Author : Jonathan Sugar=0A= *=0A= * Various functions to deliver personalisation functionality.=0A= */=0A= =0A= // Pre-declare userName so it's available when we need to test if the = page=0A= // assembler ran OK=0A= var userName =3D null;=0A= var shcrtCookie =3D null;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Factory Methods=0A= =0A= // Simple wraper object to encapsulate the data for a co-branding item.=0A= function coBrandingItem(image, imageAltText, href)=0A= {=0A= //alert("Making new coBrandingItem:\nImage: " + image + = "\nimageAltText" + imageAltText + "\nhref: " + href);=0A= this.image =3D image;=0A= this.imageAltText =3D imageAltText;=0A= this.href =3D href;=0A= }=0A= =0A= /*=0A= * Insert the 'Customer co-branding' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert customer co branding. Loop through 'customerCoBranding' array=0A= * inserting XHTML where needed.=0A= *=0A= * NOTE: the array contains ONLY the resource location (the location of a = gif=0A= * on the file system), the required XHTML is then added where needed. = This way=0A= * we maintain the seperation between presentation and content.=0A= */=0A= function insertCustomerCoBranding(maxBranding)=0A= {=0A= if( customerCoBranding[0].image !=3D "none")=0A= {=0A= document.writeln('

');=0A= document.writeln('

');=0A= document.writeln('

' + imageAltText + '
' + imageAltText + = '
More Providers

');=0A= document.writeln('

');=0A= document.writeln('

3D""

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the 'My Area' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= *=0A= * My profile link absolute as this file isnt only run from w3 anymore.=0A= */=0A= function insertMyArea(userdata)=0A= {=0A= // just in case the page assembler isn't running.=0A= =0A= =0A= if (userName !=3D null)=0A= {=0A= document.writeln("

" + = userName.substring(0,33) + "..., access your
" + userName + = ", access your

My Profile"); =0A= } =0A= document.writeln(getLoginOutLink());=0A= //CR 3652 getAthenStatus() as added=0A= document.writeln(getAthenStatus());=0A= document.writeln("

");=0A= } else {=0A= if(typeof(environment)!=3D'undefined' && = environment=3D=3D'PRODUCTION') {=0A= document.writeln("

Log Out");=0A= document.writeln("

"); =0A= }=0A= }=0A= if (menuloadedflag){=0A= wisMenu();=0A= }=0A= }=0A= =0A= /*=0A= * Insert the Customer Admin 'Login/Logout' link=0A= * -----------------------------=0A= *=0A= * Author: Bobby Jack, December 2004.=0A= *=0A= */=0A= function insertAdminLink(page)=0A= {=0A= val =3D getCookie("AID");=0A= =0A= if (val && val !=3D "-1")=0A= {=0A= document.writeln('

Logout');=0A= }=0A= else=0A= {=0A= document.writeln('

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the username section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert the username.=0A= */=0A= function insertUserName()=0A= {=0A= document.write(userName);=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the login/logout cgi=0A= * ---------------------------------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= * Had to change the links absolute as this file isnt only run from w3 = anymore.=0A= */=0A= function getLoginOutLink()=0A= {=0A= if(userName !=3D "")=0A= {=0A= return "

";=0A= }else=0A= {=0A= return "

";=0A= }=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the shopping cart content page=0A= * ---------------------------------------------------=0A= *=0A= * Author: Zhiming & Warrell June 2007=0A= */=0A= function getShCrtLink(logged)=0A= {=0A= if(logged =3D=3D true )=0A= return "

";=0A= else=0A= return "

";=0A= }=0A= =0A= function toggleShCrtLink()=0A= {=0A= shcrtCookie =3D readCookie("SHCRT");=0A= if(shcrtCookie !=3D null)=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "block";=0A= }=0A= }=0A= else=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "none";=0A= }=0A= }=0A= }=0A= =0A= =0A= =0A= function readCookie(name)=0A= {=0A= var nameEQ =3D name + "=3D";=0A= var ca =3D document.cookie.split(';');=0A= for(var i=3D0; iYou are logged in = to Athens';=0A= }=0A= else=0A= {=0A= return "

";=0A= }=0A= =0A= } ------=_NextPart_000_0000_01CA3E03.5054A8F0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/site.js /************************************************************************= ***************************=0A= FILE: site.js=0A= AUTHOR: Jonathan Sugar, Chris Neatby-Smith and Digital Pulp. July = 2003.=0A= =0A= DESCRIPTION: Javascript relating to site wide functionality across =0A= InterScience.=0A= =0A= INCLUDES FUNCTIONS=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Search Functions=0A= ----------------=0A= =0A= selectAndSubmit() - for deciding where to submit a query based on the = state of the form.=0A= processallContentSearch() - for validating form input for an all = content search.=0A= processTitleSearch() - for validating form input for a Title search.=0A= checkCitationSearch() - for validating the citation search form.=0A= selectAll() - check all the checkboxes in a form.=0A= do_popup() - stasa Acronym Finder window popup function.=0A= =0A= =0A= Other Functions=0A= ---------------=0A= =0A= fixInlineLists() - fix netscape 4.x bug where

tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract | References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if ((isNaN(parseInt(itemID))=3D=3Dtrue)||(arguments.length >=3D 4 && = arguments[3] =3D=3D 'cluster'))=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= //check whether the last 2 arguments is used for urllink.=0A= // urllink is needed to open up mail form for mrw pages on tomcat = port=0A= if (arguments.length>=3D5 && = arguments[arguments.length-2]=3D=3D'urllink' && = arguments[arguments.length-1]!=3D'')=0A= {=0A= url =3D arguments[arguments.length-1] + url;=0A= }=0A= =0A= if (arguments.length>=3D5 && arguments[3]=3D=3D'currentlink' && = arguments[4]!=3D'')=0A= {=0A= url =3D url + '¤tLink=3D' + arguments[4];=0A= =0A= //processing specific cases=0A= if (arguments[4]=3D=3D'jcatalogjsphdr')=0A= {=0A= //get the issn and pass it the next stage for processing=0A= var currloc =3D location.href;=0A= var issnloc =3D currloc.indexOf("&issn=3D");=0A= if (issnloc !=3D -1)=0A= {=0A= url =3D url + '¤tISSN=3D' + = currloc.substring(issnloc+6);=0A= }=0A= }=0A= // issn is needed for cocoon rendered mrw to form the final url.=0A= else if ( (arguments[4]=3D=3D'cocoonmrwhome') || = (arguments[4]=3D=3D'cocoonmrwarticle') )=0A= {=0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'issn' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tISSN=3D' + arguments[6];=0A= }=0A= //getting the parameters of the currently shown mrw from the = url=0A= //the method used here is a little crude, it extracts the = values from the current url of the page the user is in =0A= //to pass it to the background program to reconstruct the = requred url=0A= if (arguments[4]=3D=3D'cocoonmrwhome')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= var mrwFileParam =3D mrwParamArr[6];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= mrwFileParam =3D = mrwFileParam.substring(0,seploc);=0A= }=0A= seploc =3D mrwFileParam.indexOf("?");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwUrlParam=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= =0A= }=0A= else if (arguments[4]=3D=3D'cocoonmrwarticle')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= url =3D url + '&mrwAid=3D' + mrwParamArr[7];=0A= url =3D url + '&mrwVersion=3D' + mrwParamArr[8];=0A= var mrwFileParam =3D mrwParamArr[9];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= }=0A= }=0A= }=0A= =0A= //checking if a html file exists in the url=0A= var tmpfname =3D location.href;=0A= var loc =3D tmpfname.indexOf("?");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(0,loc);=0A= }=0A= loc =3D tmpfname.indexOf(".html");=0A= if (loc !=3D -1)=0A= {=0A= loc =3D tmpfname.lastIndexOf("/");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(loc+1);=0A= url =3D url + '¤tFile=3D' + tmpfname;=0A= }=0A= }=0A= =0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'currentyear' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tYear=3D' + arguments[6];=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln(' 3D"blank"

');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln(' 3D"blank"

'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x" + = liels[j].innerHTML + "

You do not have = anything saved in this menu.

";=0A= else=0A= tmpinnerhtml +=3D "

" = + liels[j].innerHTML + "

"; =0A= } =0A= } else {=0A= //setup var to see if more is required=0A= var more =3D (subnodeslength < lilength) ? true : = false; =0A= var flag =3D true;=0A= for (var j=3D0; j" + liels[j].innerHTML + = "";=0A= } else if (j > lilength-3){=0A= if (j =3D=3D lilength-2){=0A= var url =3D liels[j].innerHTML.split('"')[1];=0A= tmpinnerhtml +=3D "

" + liels[j].innerHTML + "

";=0A= } else {=0A= tmpinnerhtml +=3D "

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Brain Pathology

ISSN: 1750-3639 (Online)

ISSN: 1015-6305 (Print)

Volume 17, Issue 3, 2007.

Pages: 308=96313

Top of Page
Abstract
INTRODUCTION
PAPILLARY GLIONEURONAL TUMOR
ROSETTE-FORMING GLIONEURONAL TUMOR OF THE FOURTH = VENTRICLE
ACKNOWLEDGMENTS
References

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Abstract=20 Only

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July = 2003.=0A= =0A= DESCRIPTION: Javascript relating to site wide functionality across =0A= InterScience.=0A= =0A= INCLUDES FUNCTIONS=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Search Functions=0A= ----------------=0A= =0A= selectAndSubmit() - for deciding where to submit a query based on the = state of the form.=0A= processallContentSearch() - for validating form input for an all = content search.=0A= processTitleSearch() - for validating form input for a Title search.=0A= checkCitationSearch() - for validating the citation search form.=0A= selectAll() - check all the checkboxes in a form.=0A= do_popup() - stasa Acronym Finder window popup function.=0A= =0A= =0A= Other Functions=0A= ---------------=0A= =0A= fixInlineLists() - fix netscape 4.x bug where

tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. 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"+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract | References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if ((isNaN(parseInt(itemID))=3D=3Dtrue)||(arguments.length >=3D 4 && = arguments[3] =3D=3D 'cluster'))=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= //check whether the last 2 arguments is used for urllink.=0A= // urllink is needed to open up mail form for mrw pages on tomcat = port=0A= if (arguments.length>=3D5 && = arguments[arguments.length-2]=3D=3D'urllink' && = arguments[arguments.length-1]!=3D'')=0A= {=0A= url =3D arguments[arguments.length-1] + url;=0A= }=0A= =0A= if (arguments.length>=3D5 && arguments[3]=3D=3D'currentlink' && = arguments[4]!=3D'')=0A= {=0A= url =3D url + '¤tLink=3D' + arguments[4];=0A= =0A= //processing specific cases=0A= if (arguments[4]=3D=3D'jcatalogjsphdr')=0A= {=0A= //get the issn and pass it the next stage for processing=0A= var currloc =3D location.href;=0A= var issnloc =3D currloc.indexOf("&issn=3D");=0A= if (issnloc !=3D -1)=0A= {=0A= url =3D url + '¤tISSN=3D' + = currloc.substring(issnloc+6);=0A= }=0A= }=0A= // issn is needed for cocoon rendered mrw to form the final url.=0A= else if ( (arguments[4]=3D=3D'cocoonmrwhome') || = (arguments[4]=3D=3D'cocoonmrwarticle') )=0A= {=0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'issn' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tISSN=3D' + arguments[6];=0A= }=0A= //getting the parameters of the currently shown mrw from the = url=0A= //the method used here is a little crude, it extracts the = values from the current url of the page the user is in =0A= //to pass it to the background program to reconstruct the = requred url=0A= if (arguments[4]=3D=3D'cocoonmrwhome')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= var mrwFileParam =3D mrwParamArr[6];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= mrwFileParam =3D = mrwFileParam.substring(0,seploc);=0A= }=0A= seploc =3D mrwFileParam.indexOf("?");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwUrlParam=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= =0A= }=0A= else if (arguments[4]=3D=3D'cocoonmrwarticle')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length 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Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. 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return hwnd; } =0A= function pagetitle() {return 'Brain Pathology Vol. 17, 3 Pages: = 308-313'; } =0A= function dochead(hwnd, spec) {var title =3D pagetitle(); = hwnd.document.open(); = hwnd.document.write(''+spec+title+''); } =0A= function doctail(hwnd) {hwnd.document.write(''); } =0A= function pagehead(hwnd) {hwnd.document.write('

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Online ISSN: = 1096-9896 Print ISSN: 0022-3417
The Journal of = Pathology
Volume 214, Issue 3, 2008. Pages: 328-336

Copyright =C2=A9 2007 Pathological Society of Great = Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Copyright Journal Compilation = © 2007 International Society of Neuropathology

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Brain Pathology

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Volume 17, Issue 3, Pages 308-313

Published Online: 26 Jun 2007

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SYMPOSIUM: The 2007 Revised World = Health=20 Organization (WHO) Classification of Tumours of the Central = Nervous=20 System: Newly Codified Entities

The 2007 WHO Classification of Nervous = System=20 Tumors: Newly Recognized Members of the Mixed Glioneuronal=20 Group

Marc=20 K. Rosenblum, MD

Department of = Pathology, Memorial=20 Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY=20 10021.

Correspondence to Marc K. = Rosenblum,=20 MD, Department of Pathology, Memorial Sloan-Kettering Cancer = Center, 1275=20 York Avenue, New York, NY 10021 (E-mail: rosenbl1@mskcc.org)=20

Copyright Journal Compilation =A9 2007 = International Society of Neuropathology

ABSTRACT

3DAbstract=20

The clinical and pathologic features of two = glioneuronal=20 neoplasms newly incorporated in the 2007 revision of the WHO=20 classification of nervous system tumors are reviewed. These are = the=20 papillary glioneuronal tumor and the rosette-forming glioneuronal = tumor of=20 the fourth ventricle.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1750-3639.2007.00079.x About=20 DOI

=20

=20

=20

INTRODUCTION

Two unusual neoplasms of mixed glioneuronal nature = are now=20 recognized as novel, distinct entities in the newly updated WHO = taxonomy=20 of tumors of the central nervous system. These are the papillary=20 glioneuronal tumor (27)=20 and the rosette-forming glioneuronal tumor (RGNT) of the fourth = ventricle=20 (14).

=20

=20

PAPILLARY GLIONEURONAL TUMOR

This morphologically distinctive neoplasm was = originally=20 described by Komori et al. (20)=20 in 1996 as "pseudopapillary ganglioglioneurocytoma" and thereafter = designated "papillary glioneuronal tumor" (PGNT) in an expanded = 1998=20 series detailing the clinical and pathologic features of nine = cases (21).=20 An intercurrent report from Kim and Suh (19)=20 in 1997 communicated one example as a "pseudopapillary neurocytoma = of=20 temporal lobe with glial differentiation." Subsequent publications = have=20 consistently referred to this entity as PGNT and it is under this=20 designation that the lesion appears in the 2007 WHO classification = (27).

=20

Demographic and clinical=20 features. The actual (population-based) incidence of = PGNT is=20 unknown, but the tumor is certainly rare. To date, 35 examples = have been=20 described and illustrated in full-length case report or series = format (3=9613,=20 15, 17, 19, 21, 23, 24, 26, 28, 30=9634). These have affected = 19 females=20 and 16 males, aged 4=9675 years (mean, 26 years), being most = prevalent in=20 the second and third decades of life. Only four cases have = occurred in=20 adults older than 40 years of age. Except for one-third = ventricular=20 example (31),=20 all have been situated in the cerebral hemispheres, particularly = the=20 temporal and frontal lobes where they comprise 13 and 11 examples, = respectively. Headache and seizures are the most common clinical=20 manifestations. Other presenting complaints include nausea, = vertigo,=20 visual and gait disturbances, focal sensorimotor deficits, = syncope, memory=20 loss, mood changes and difficulties in verbal comprehension or = expression.=20 Headache of sudden onset with rapid progression to aphasia and = coma has=20 been described as a consequence of tumoral hemorrhage (8).=20 Isolated examples of PGNT have been reported in patients with = cleft lip=20 and orbital schwannoma (21),=20 but none have occurred in association with a dysgenetic syndrome = or in a=20 familial setting.

=20

Neuroradiologic=20 appearances. Both CT and MR studies show PGNTs to be=20 circumscribed supratentorial lesions that may span the cortical = ribbon and=20 underlying white matter or be more deeply situated, abutting the = lateral=20 ventricular system. Cystic alterations are frequent. Solid = components are=20 T₁-iso/hypointense,=20 T₂-iso/hyperintense, usually = contrast-enhancing in=20 a diffuse, patchy or rimming fashion, and may present as mural = nodules or=20 plaques within otherwise cystic masses (Figure 1).=20 Calcifications may be seen. Significant tumoral hemorrhage is = exceptional,=20 but on record (8),=20 as is an example associated with superficial siderosis of the = neuraxis (23).=20 Edema and conspicuous mass effect are generally limited to larger = lesions.=20 Reported tumor dimensions range from 1=969 cm (mean,=20 4.5 cm).

=20

= Figure 1. As is=20 often the case, the solid component of this papillary = glioneuronal=20 tumor is contrast-enhancing on post-gadolinium=20 T₁-weighted MR imaging. Note its = projection=20 into a sizable cyst.

[Normal View=20 ]

=20

Morphologic and = immunophenotypic=20 features. Papillary glioneuronal tumors are unique = among=20 central nervous system neoplasms in their juxtaposition of = (pseudo)=20 papillary gliovascular structures and interposed = neurocytic/neuronal=20 tissue (Figure 2A).=20 The former consist of compactly arranged, hyalinized blood vessels = of=20 modest caliber surrounded by a monolayer or pseudostratified layer = of=20 small, cuboidal glial cells with rounded nuclei and relatively = scant,=20 eosinophilic cytoplasm (Figure 2B)=20 that consistently immunolabel for glial fibrillary acidic protein = (GFAP;=20 Figure 2C)=20 and S-100 protein (21).=20 These cells do not elaborate the perivascular cytoplasmic = processes=20 typical of ependymoma and astroblastoma, but rather sit squarely = on their=20 fibrovascular supports and may form solid interpapillary = aggregates.=20 Neither mitotic activity nor cytologic atypia is seen. = Ultrastructural=20 studies show these cells to contain bundles of intermediate = filaments of=20 glial type (6,=20 19, 21) and to form juxtavascular basal lamina (21).

=20

= Figure 2. Histologic and immunophenotypic features of = papillary=20 glioneuronal tumor. A. = Papillary=20 gliovascular structures (left) abruptly give way to solid = components=20 containing oligodendrocyte-like clear-cell neurocytic = elements.=20 B. Small, cuboidal cells of uniform = appearance=20 cover hyalinized fibrovascular cores in papillary regions. = C. Cytoplasmic immunolabeling for glial = fibrillary=20 acidic protein attests to the glial nature of papillary = elements.=20 D. Non-papillary components include = small round=20 cells, many of oligodendrocyte-like appearance but = representing=20 neurocytes, as well as larger neurons (arrow). E. Neuronal elements of intermediate type=20 ("ganglioid" cells) exhibit vesicular nuclei and distinct = nucleoli,=20 but little rimming cytoplasm. Note myxoid change. F. Intense synaptophysin labeling is = evidenced in=20 intermediate neuronal elements, while cells surrounding = vascular=20 papillae (left) are non-reactive. Deeply eosinophilic cells = of=20 minigemistocytic or coarsely granulated appearance may be = found=20 adjacent to papillary structures (G), = or=20 admixed with small, clear-cell neurocytic elements (H).

[Normal View=20 ]

Interspersed between or regionally separate from = the=20 gliovascular papillae described above are monomorphous = non-papillary=20 aggregates of neuronal cells in a fine, neuropil-like matrix prone = to=20 myxoid change. These cytologically varied cells include neurocytes = with=20 dense round nuclei, well-differentiated neurons of medium-size, = large=20 ganglion cells and, prominent in many tumors, transitional forms = having=20 vesicular nuclei of intermediate size, relatively small nucleoli = and=20 narrow rims of amphophilic or violet-hued cytoplasm (Figure 2D,E).=20 Granular immunoreactivity for synaptophysin (SYN), = characteristically=20 strong, is a regular feature of the matrix within which these = various=20 cells are disposed. The neurons and transitional forms also = exhibit=20 diffuse cytoplasmic as well as punctate surface labeling for this = neuronal=20 marker (21)=20 (Figure 2F).=20 Other neuron-associated antigens that may be expressed include=20 neuron-specific enolase (NSE), microtubule-associated protein 2 = (MAP2),=20 class III β-tubulin, neural cell adhesion molecule (NCAM) and = NeuN (10,=20 15, 21, 31, 33). Assessment of one PGNT by Western blot = analysis=20 revealed a "mature" pattern of neuron-associated adhesion complex=20 expression as evidenced by elaboration of the L1 adhesion molecule = and the=20 180 kd NCAM isoform that is characteristic of fully = differentiated=20 neurons, but absence of the polysialylated NCAM isoform elaborated = in the=20 developing CNS (6).=20 In most PGNTs, immunolabeling for neurofilament protein (NFP) is=20 restricted to larger neuronal ("ganglioid") and ganglion cell = populations,=20 and absence of chromogranin a (CHR) expression is the rule (21).=20 Not surprisingly, ultrastructural studies have shown that the=20 non-papillary regions within PGNTs contain cells manifesting = neuronal=20 specializations (cytoplasmic extensions replete with aligned = microtubules,=20 clear vesicles and dense-core granules in limited numbers, as well = as=20 synaptic contacts of varying organization) (6,=20 19, 21). Hybrid glioneuronal cells have not been = identified.

A subset of PGNTs contain minigemistocytes or = coarsely=20 granulated cells (both GFAP-labeling) of the sort encountered in=20 oligodendrogliomas, these lying between papillary structures or = nestled=20 among neuronal cell types in non-papillary areas (Figure 2G,H).=20 Tanaka et al (31)=20 have suggested that PGNTs are capable of oligodendroglial = differentiation,=20 identifying within these lesions a population of small cells that = fail to=20 label for GFAP or NeuN but express the Olig2 transcription factor. = Distributed principally in interpapillary areas surrounding = GFAP-positive=20 perivascular elements, these may correspond to cells identified by = Komori=20 et al (21)=20 as having non-specific fine structural appearances indicative of = neither=20 astrocytic nor neuronal differentiation. In the cases studied by = Tanaka=20 et al (31),=20 minigemistocytes tended to an intimate association with these=20 Olig2-labeling forms and were thought to derive from them. = Although Olig2=20 cannot be regarded as an oligodendrocyte-specific "marker" in the=20 neoplastic context, the notion that at least some of the putative=20 neurocytes are cells differentiated along oligodendroglial lines = merits=20 further investigation.

Secondary changes that may be seen in PGNTs = include foam=20 cell infiltration, hemosiderin deposition, hyaline stromal = fibroplasia and=20 dystrophic calcification. Specimens containing adjacent brain = parenchyma=20 typically show only a narrow zone of tumor infiltration or a = discrete,=20 "pushing" border that provokes chronic piloid astrogliosis with = Rosenthal=20 fiber formation. Mitotic figures are typically absent to rare, if=20 demonstrable at all, and MIB-1 labeling indices usually do not = exceed=20 2%=963%. In the series of Komori et al (21),=20 the mean MIB-1 index was 1.3% (range, 0.5%=962.5%). Papillary = glioneuronal=20 tumors exhibiting more conspicuous proliferative activity have = been=20 reported (see Clinical Biology and Grading below). Similar to = conventional=20 PGNTs, however, such atypical examples exhibit neither complex=20 microvascular hyperplasia nor necrosis.

=20

Genetic=20 features. Chromosome 1p was found to be intact in six = PGNTs=20 examined by fluorescence in situ = hybridization (31).=20 One example studied by the author showed no deletions of = chromosomes 1p or=20 19q by loss of heterozygosity analysis (unpublished=20 observation).

=20

Clinical biology and=20 grading. Papillary glioneuronal tumors are not = accorded a=20 precise grade in the 2007 WHO monograph (27),=20 which, based on experience reported to date, states that they = generally=20 behave in grade I fashion and are amenable to control by surgical = means. A=20 survey of 24 cases with follow-up (range 2=9684 months; mean, 22 = months)=20 reveals no instance of tumor regrowth when treated by gross total=20 resection alone. Two additional patients treated by gross total = excision=20 and radiotherapy are free of tumor at 5 years (34)=20 and 19 years (13),=20 with the former patient having had an "atypical" PGNT with = occasional=20 mitoses and a MIB-1 labeling index of 15%. On the other hand, one=20 abbreviated report (17)=20 (abstract only), mentions multifocal recurrence 4 years after an=20 ostensibly complete resection of one PGNT with a MIB-1 index of 5% = (17).=20 One typical PGNT exhibited no regrowth 3 years following subtotal=20 resection (28),=20 while another experienced progression of a subtotally resected = tumor with=20 a MIB-1 index of 4% only 3 months after surgery (17).=20 One example of progression following 10 years of tumor stability = in a=20 patient managed by observation alone has been communicated (15);=20 in this case, subtotal resection revealed a PGNT with a prominent=20 minigemistocytic component and a MIB-1 index of 5%=9610%. This = atypical=20 lesion exhibited regrowth 6 months following combined radiation = and=20 chemotherapy. Yet another atypical PGNT that exhibited increased = mitotic=20 activity and a 12% MIB-1 labeling index was stable 1 year after = incomplete=20 excision and chemotherapy (3).

=20

Histogenesis. Papillary=20 glioneuronal tumors are presumed to have their cellular origins in = multipotential precursor cells. Paraventricular examples could = derive from=20 elements of the subependymal matrix, while more superficially = positioned=20 cases might descend from cortical components of the secondary = germinal=20 layer.

=20

=20

ROSETTE-FORMING GLIONEURONAL TUMOR = OF THE=20 FOURTH VENTRICLE

The RGNT of the fourth ventricle seems initially = to have=20 been described in a 1995 report as a cerebellar form of = dysembryoplastic=20 neuroepithelial tumor (25),=20 but was recognized as an entity sui generis = and=20 characterized in a 2002 study of 11 cases by Komori et al (22).

=20

Demographic and clinical=20 features. Like PGNT, RGNT is also a decidedly uncommon = lesion;=20 its population-based incidence is unknown. Nineteen examples have = been=20 reported in full-length study form (1,=20 2, 16, 18, 22, 25, 29). These affected 12 females and 7 males = aged=20 12=9659 years (mean, 31.7 years). Older patients may also be = affected; the=20 author has seen two cases in patients over age 65 years. The most = common=20 presenting manifestations are headache (secondary to obstructive=20 hydrocephalus) and ataxia, followed by visual disturbances and = vertigo.=20 Neck pain and rigidity have also been reported. Incidental = neuroradiologic=20 discovery of RGNT has been described. In six reported cases, = symptoms=20 referable to the tumor preceded discovery by at least 2 years. A=20 coexistant Chiari type I malformation has been noted in a single = case (22),=20 but RGNTs have not been described in familial form or in the = setting of=20 any recognized dysgenetic syndrome.

=20

Localization and = neuroradiologic=20 appearances. Although CT and MRI studies typically = show RGNTs=20 to be midline lesions centered in the fourth ventricle, limited = extension=20 into the cerebellar vermis, brainstem and cerebral aqueduct may be = seen.=20 Tumors primarily situated in the tectal/pineal and acqueductal = regions are=20 on record (16,=20 22), as are multifocal lesions with fourth ventricular, = vermian,=20 dorsal pontine and, in one case, mesencephalic and thalamic = components (22).=20 RGNTs are relatively circumscribed, may be solid or multicystic, = and=20 usually exhibit at least focal contrast-enhancement that may be = nodular,=20 linear, ring or spot-like (Figure 3).=20 On MR assessment, T₁-iso/hypointensity and = T₂-hyperintensity are the rule. = Calcification is=20 occasionally seen and may be extensive. There may be associated = edema, but=20 this is generally minimal. Tumor dimensions range in size from = 1=965 cm=20 (mean, 3.3 cm).

=20

= Figure 3. Filling=20 the fourth ventricle, this rosette-forming glioneuronal = tumor=20 exhibits linear contrast-enhancement on post-gadolinium=20 T₁-weighted MR imaging.=20

[Normal View=20 ]

=20

Morphologic and = immunophenotypic=20 features. The RGNT is distinctive in its juxtaposition = of=20 patterned neurocytic and piloid astroglial components. The former, = with=20 their small, uniform round nuclei, evenly distributed delicate = chromatin=20 and scant cytoplasm form narrow perivascular pseudorosettes as = well as=20 diminutive Homer Wright-like rosettes that can be arrayed in = cribriform=20 pattern and that sometimes lie unanchored within tumoral = microcavities (Figure 4A,B).=20 Sectioning along the vascular axes of pseudorosettes frequently = imparts=20 the appearance of columnar organization (Figure 4C),=20 which is often accompanied by myxoid and microcystic alterations, = and may=20 therefore bring to mind the specific glioneuronal element of=20 dysembryoplastic neuroepithelial tumor. The latter's complement of = mature=20 "floating" neurons, however, is not a feature of RGNT, although a = minority=20 of RGNTs have been described as harboring small numbers of = dysmorphic=20 ganglion cell-like neuronal forms embedded within otherwise = astrocytic=20 regions (22).

=20

= Figure 4. Histologic and immunophenotypic features of = rosette-forming=20 glioneuronal tumor (RGNT). A. = Diminutive=20 rosettes often seem to float in tumoral clefts or cavities = (right)=20 that border solid astrocytic components. Perivascular=20 pseudorosetting is also seen (left). B. True=20 Homer Wright-like rosettes consist of delicate fibrillar = cores=20 rimmed by small, monomorphous, rounded nuclei. C. Perivascular pseudorosettes assume = columnar=20 configurations when sectioned along vascular axes. Myxoid = and=20 microcystic alterations are apparent. D.=20 Rosettes consistently manifest granular synaptophysin=20 immunoreactivity of their cores. E. = Glial=20 components of the RGNT are usually dominated by spindled = astroglial=20 cells that may achieve moderate cell density and are = immunoreactive=20 for glial fibrillary acidic protein (GFAP) (F).=20 G. Small oligodendrocyte-like cells = may also=20 populate glial regions and are non-reactive for GFAP and=20 neuron-associated antigens. H. = Complex=20 microvascular proliferation is a feature of some = RGNTs.=20

[Normal View=20 ]

Immunohistochemical studies of RGNT show that the = delicate=20 matrix of both the Homer Wright-like rosettes and the perivascular = pseudorosettes label for SYN in granular fashion (Figure 4D).=20 The fine cytoplasmic processes of these structures are also = reactive for=20 NSE and MAP-2, but lack staining for CHR, GFAP and, in most hands, = NFP and=20 S-100 protein (16,=20 22, 25, 29). The nuclei of the rosetted cells have been = described in=20 selected cases to manifest reactivity for PGP 9.5 (25),=20 S-100 protein (16),=20 or NeuN (16).=20 In accord with the observations of Preusser et al (29),=20 the author has been unable to demonstrate NeuN immunolabeling of = rosetted=20 cells in five personally examined cases. Ultrastructural studies = have=20 confirmed the neuronal nature of these patterned elements, showing = them to=20 form cytoplasmic processes containing parallel microtubules and = small=20 numbers of dense-core granules, and potentially forming = well-developed=20 synaptic contacts (1,=20 22).

The often dominant glial component of RGNT tends = to exhibit=20 pilocytic astrocytoma-like morphology. Spindled (Figure=20 4E) and, in some cases, stellate astroglial elements radiate = lengthy=20 cell processes that are GFAP and S-100 protein-positive (Figure 4F).=20 Ultrastructurally, they are filled with bundles of intermediate = filaments=20 of glial type (22).=20 There is considerable intra- and inter-tumoral variation in the = levels of=20 cellularity of the astrocytic constituent, ranging from a cellular = density=20 that is unarguably neoplastic to a hyponuclear fibrillary meshwork = that is=20 difficult to accept as anything but a glial scar. Strengthening = the=20 resemblance to pilocytic astrocytoma is the finding in some cases = of=20 Rosenthal fibers, eosinophilic granular bodies, and=20 GFAP-negative/SYN-negative clear cells of oligodendrocyte-like = appearance=20 that form microcysts or aggregate in sheets (Figure 4G).=20 The latter may exhibit S-100 protein immunolabeling. As mentioned, = dysmorphic neurons of ganglion cell dimension may be found in the = glial=20 regions of RGNT but are not seen in conspicuous numbers.

In addition to regions of gliotic-appearing = tissue, RGNTs=20 commonly manifest stromal alterations indicative of chronicity and = degeneration. These include vasosclerosis and dense = collagenization,=20 microcalcifications, hemosiderin deposits indicative of prior = hemorrhage=20 and, in an occasional case, focal infarction because of vascular=20 thrombosis. Ectatic and hyalinized blood vessels with fibrin = deposition=20 may cluster in malformation-like complexes. RGNTs can exhibit=20 proliferative microvasculature of the complex, glomeruloid type = (Figure 4H),=20 but are typically devoid (or very nearly so) of mitotic figures = and show=20 relatively low MIB-1 labeling. In the series of Komori et al = (22),=20 tumoral MIB-1 indices ranged from 0.35%=963.07% (mean, 1.58%). = Subsequent=20 reports have also documented similarly low labeling indices of = less than=20 1% to 2.2% (1,=20 2, 29). These reassuring features are accompanied by a = relatively=20 well-defined tumor-parenchyma interface.

=20

Clinical biology and=20 grading. Based on the experience reported to date, = RGNTs=20 emerge as generally indolent and have been accorded grade I status = in the=20 updated WHO formulation (14).=20 Only one instance of tumor regrowth after 10 years of = postoperative=20 clinical stability was found among 13 evaluable cases treated by = subtotal=20 or gross total resection alone (16).=20 The remaining 12 patients so treated remained recurrence-free = 2=96162 months=20 after operation, with follow-up intervals extending over a period = of at=20 least 24 months in half of the cases (1,=20 2, 16, 22, 29). Two patients in this group had multifocal = RGNTs that=20 exhibited no enlargement of untreated nodules through 2 years of=20 post-surgical surveillance (22),=20 although isolated examples of lesion growth over relatively brief = (6=20 month) periods of pre-treatment observation have been described = (16,=20 22). Dissemination via the cerebrospinal fluid has not been = reported.=20 The sole tumor-associated fatality on record followed partial = excision and=20 irradiation of an RGNT in a 52-year-old woman who subsequently = developed=20 progressive bulbar dysfunction related to a new ring-enhancing = abnormality=20 near the operative bed; the patient died 45 months after initial = treatment=20 (22).=20 As an autopsy was not performed, the cause of death in this case = is=20 unclear. While RGNTs are associated with a favorable prognosis in = terms of=20 survival, their location complicates surgical removal and a = significant=20 risk of neurologic injury, principally ataxia and sixth and = seventh=20 cranial nerve palsies, attends attempts at excision (2,=20 22).

=20

Histogenesis. RGNTs are=20 posited to derive from elements capable of divergent neuronal and = glial=20 differentiation, and may have their origin in the pluripotential = cells of=20 the subependymal plate.

=20

=20

=20

ACKNOWLEDGMENTS

The author would like to thank Allyne Manzo for = assistance=20 with photomicroscopy and Donna Bauer for bibliographic research = and=20 manuscript preparation.

=20

=20

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