From: Subject: Chemical genetics reveals a complex functional ground state of neural stem cells: Nature Chemical Biology Date: Thu, 17 Jan 2008 17:30:24 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C8592E.A4BB86E0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C8592E.A4BB86E0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nchembio/journal/v3/n5/full/nchembio873.html Chemical genetics = reveals a complex functional ground state of neural stem cells: Nature = Chemical Biology
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Letter

Nature Chemical Biology = 3, 268-273 (2007)
doi:10.1038/nchembio873

Chemical genetics reveals a complex functional ground state = of neural=20 stem cells

Phedias Diamandis1,2,3,4,=20 Jan Wildenhain4,=20 Ian D Clarke1,2,=20 Adrian G Sacher1,2,=20 Jeremy Graham1,2,=20 David S Bellows3,=20 Erick K M Ling1,2,5,=20 Ryan J Ward1,2,5,=20 Leanne G Jamieson1,2,5,=20 Mike Tyers3,4=20 and Peter B Dirks1,2,5,6

The identification of self-renewing and multipotent = neural stem=20 cells (NSCs) in the mammalian brain holds promise for the treatment of=20 neurological diseases and has yielded new insight into brain = cancer1,2,3.=20 However, the complete repertoire of signaling pathways that governs the=20 proliferation and self-renewal of NSCs, which we refer to as the 'ground = state',=20 remains largely uncharacterized. Although the candidate gene approach = has=20 uncovered vital pathways in NSC biology4,5,6,7,8,=20 so far only a few highly studied pathways have been investigated. Based = on the=20 intimate relationship between NSC self-renewal and neurosphere=20 proliferation8,=20 we undertook a chemical genetic screen for inhibitors of neurosphere=20 proliferation in order to probe the operational circuitry of the NSC. = The screen=20 recovered small molecules known to affect neurotransmission pathways = previously=20 thought to operate primarily in the mature central nervous system; these = compounds also had potent inhibitory effects on cultures enriched for = brain=20 cancer stem cells. These results suggest that clinically approved=20 neuromodulators may remodel the mature central nervous system and find=20 application in the treatment of brain cancer.

To profile the signaling network of primary cultures of = neural=20 precursor cells (NPCs), we screened 1,267 compounds in the library of=20 pharmacologically active compounds (LOPAC) for inhibitors of neurosphere = proliferation, as measured by incorporation of the vital dye thiazolyl = blue=20 tetrazolium bromide (MTT) (Fig.=20 1a,b and Supplementary=20 Table 1 online). A Z' factor9=20 of 0.78 and a Pearson correlation coefficient of 0.981 for replicate = screens=20 indicated that the assay was reliable (Supplementary=20 Methods online). 160 compounds that significantly inhibited = neurosphere=20 proliferation (P < 0.01) were clustered into groups of known=20 pharmacologic action (Table=20 1 and Supplementary=20 Table 2 online). Known cytotoxic compounds that target essential = cellular=20 processes predictably scored as hits in the screen. Unexpectedly, = however, many=20 agents that modulate neurotransmission in the dopamine, serotonin, = opioid,=20 glutamate, vanilloid and other pathways potently inhibited growth of = NPCs. Many=20 of these agents are used in the clinical treatment of neurological = disorders and=20 are traditionally thought to act on mature central nervous system (CNS) = cell=20 populations. These compounds induced a variety of neurosphere = phenotypes,=20 including changes in sphere number, sphere size, and cell-cell or = cell-surface=20 adhesion properties, which suggests that an elaborate balance of these = signaling=20 pathways dictates NPC fate (Fig.=20 1c).

Figure=20 1: HTS of NPCs.

(a) Neurospheres are derived from self-renewing = multipotent=20 NSCs and contain a heterogeneous mixture of stem cells, progenitor = cells, and a=20 very small number of differentiated cells. (b) Scatter plot of = all 1,267=20 compounds of the LOPAC library screened against NPCs. 160 compounds = ()=20 were identified as inhibitors of neurosphere proliferation (P = < 0.01),=20 19 compounds ()=20 were identified as activators (P < 0.01) and the remaining = agents=20 ()=20 screened did not have any significant effects on proliferation (P = >=20 0.01). (c) Examples of phenotypic variation observed in response = to=20 particular agents. Scale bars, 250 m. = HTS,=20 high-throughput screen.

Full=20 figure and legend (80K)Figures,=20 schemes & tables index

Table=20 1: HTS bioactive pharmacological classes


Full=20 tableFigures,=20 schemes & tables index

To verify hits from the primary screen, 43 = representative=20 candidates were retested at the original screen concentration of 3 M; of=20 these, 40 (93%) showed significant activity (P<0.05) (Supplementary=20 Table 3 online). Because other neural cell types express and signal = through=20 a number of neurotransmitter receptors10,=20 we assessed the selectivity and potency of each agent for a normal mouse = astrocyte cell line versus NPCs. Dose-response curves were generated for = 28=20 compounds in both neurosphere and astrocyte cultures and used to = determine the=20 effective concentration needed to decrease proliferation by 50%=20 (EC50) (Fig.=20 2a=96f and Supplementary=20 Table 3). A neurosphere selectivity ratio, defined as=20 EC50(astrocytes)/EC50(neurospheres), was = determined for=20 each compound and compared with that of known nonspecific inhibitors of=20 proliferation (Fig.=20 2a=96c). Compounds that had a neurosphere selectivity ratio greater = than that=20 observed in these control agents (>5.08) were defined as NPC-specific = agents=20 (Fig.=20 2d=96f and Table=20 2); 12 of the compounds tested showed high selectivity for NPCs. = Notably,=20 the serotonin agonist = p-aminophenethyl-m-trifluoromethylphenyl=20 pierazine (PAPP, Compound 14) and the vanilloid receptor ligand = dihydrocapsaicin were respectively 702- and 192-fold more selective for = normal=20 NPCs than for astrocyte cultures.

Figure=20 2: Identification of potent NPC-specific compounds.

(a=96f) Dose-response curves and chemical = structures of=20 controls: cycloheximide (a), etoposide (b) and carboplatin = (c), and of selected newly identified compounds: dihydrocapsaicin = (d), apomorphine (e) and PAPP (f). Each plot shows = the=20 fitted sigmoidal logistic curve to MTT proliferation assay readings of = both=20 astrocytes (- --=20 -) and neurosphere cultures (=96=96).=20 Values represent the mean and s.e.m. of three independent experiments.=20 (g) Replating colony forming efficiency of pretreated neurosphere = cultures. Values represent the number of progeny neurospheres arising = from 2,000=20 or 1,000 cells plated in fresh medium after a 7-d pretreatment of NPCs = with the=20 indicated inhibitor at the estimated EC75 value. As the=20 EC75 of apomorphine did not allow the recovery of sufficient = cells,=20 an EC50 pretreatment was used for this agent. Sphere counts = for=20 vehicle-treated cells represent the mean and s.d. of six separate = replicates=20 conducted during two independent experiments. All other values represent = the=20 mean of two independent experiments. Asterisks indicate a reproduced=20 statistically significant (P < 0.05) reduction in replating = efficiency=20 when compared to vehicle control. The larger P value (of the two=20 experiments) is reported. These differences (at both 2,000 and 1,000 = cells per=20 well) were confirmed (two-tailed paired t-test) for cultures = treated with=20 PAPP (P2,000 =3D 0.02; P1,000 =3D = 0.008) and=20 apomorphine (P2,000 =3D 0.01; P1,000 = =3D 0.02)=20 in three independent trials.

Full=20 figure and legend (95K)Figures,=20 schemes & tables index

Table=20 2: Highly potent and highly selective compounds identified by HTS of=20 neurospheres


Full=20 tableFigures,=20 schemes & tables index

Neurospheres are comprised of a heterogeneous population = of NSCs=20 and lineage-restricted progenitor cells. To determine whether the = inhibitors=20 affected NSC self-renewal, as opposed to proliferation of more committed = precursor populations, we analyzed the higher order colony-forming = efficiency of=20 treated neurosphere cultures. With the exception of dihydrocapsaicin,=20 representative compounds from the main neurotransmission classes = significantly=20 reduced higher order neurosphere formation upon re-culture in the = absence of=20 drug (Fig.=20 2g). The various inhibitors therefore seem to target the neural = precursor=20 pool that is predominantly responsible for sphere formation.

To further delineate the mechanism through which = neuromodulatory=20 agents impede expansion of NPCs in culture, we performed time-course = analyses=20 for both cell viability and apoptosis. Unlike etoposide (Fig.=20 3a) and cycloheximide (data not shown), which have immediate effects = on cell=20 proliferation and viability, the neurotransmission modulators PAPP and=20 ifenprodil decreased viable cell numbers only after 2 d post-treatment = (Fig.=20 3a). Similar delayed-onset effects were observed for butaclamol,=20 p-fluoro-hexahydrosila-difenidol (p-F-HHSiD, Compound 8) and carbetapentane (data not = shown).=20 Consistently, caspase-3 and caspase-7 concentrations were unchanged = after 12 h=20 of PAPP and ifenprodil treatment, but increased significantly=20 (P<0.001) after 2 d of drug treatment (Fig.=20 3b). This increase in the apoptotic response of treated cells = occurred at=20 concentrations of drugs that did not abolish the initial proliferation = or=20 viability of these cells (Fig.=20 3c). Finally, expression of the immature NPC marker nestin was = substantially=20 decreased after treatment for 2 d with ifenprodil (Fig.=20 3d) and PAPP (data not shown). These results suggest that = appropriate=20 neurotransmission signaling is required to maintain NSC proliferation, = survival=20 and identity.

Figure=20 3: Temporal effects of neuromodulators on NPC viability and = apoptotic=20 response.

(a) Proliferation dynamics of PAPP-, ifenprodil- = and=20 etoposide-treated NPCs. (b) Normalized caspase-3 and caspase-7 = activity=20 in NPCs after 12 h and 48 h of drug treatment. Asterisk indicates a = significant=20 change (two-tailed t-test) from the corresponding vehicle-treated = data=20 point. (c) Corresponding MTT values taken at 12 h and 2 d for the = caspase-3 and caspase-7 experiments shown in b. All values = represent the=20 mean and s.d. of one representative experiment (from three independent = trials)=20 of NPCs treated with PAPP (1 M),=20 ifenprodil (3 M),=20 etoposide (3 M) or=20 vehicle. (d) Flow cytometric analysis of the neural precursor = marker=20 nestin in NPCs after 2 d of treatment with ifenprodil (5 M) or=20 vehicle. Representative histograms of vehicle-treated (20% nestin = negative) and=20 ifenprodil-treated (63% nestin negative) cells compared with the isotype = control=20 (100% nestin negative) are shown from two independent experiments.

Full=20 figure and legend (73K)Figures,=20 schemes & tables index

As gene expression profiles of brain tumors resemble = those of=20 normal and embryonic NPCs11,12,13,14,=20 agents that inhibit normal neural precursor growth may also inhibit = cultures of=20 brain tumors that are enriched for cancer stem cells1,2,11.=20 We therefore assessed the activity of a subset of NPC-specific = inhibitors=20 against low-passage (<4) neurosphere cultures derived from = spontaneously=20 formed medulloblastomas in heterozygous patched = (Ptch1+/-) and=20 Ptch1+/-Trp53-/- mice15.=20 Like their normal counterparts, cancerous NPCs from these tumors grow as = spheres=20 in serum-free culture and express the neural precursor marker prominin1 = (CD133)=20 (Fig.=20 4a,b). The NPC-specific agents also potently suppressed the = proliferation of=20 both Ptch1+/- and=20 Ptch1+/-Trp53-/- medulloblastoma = precursor=20 cell populations (Fig.=20 4c and Table=20 2). Notably, some of these agents were an order of an magnitude more = effective in the inhibition of tumor cell growth in vitro than = the=20 hedgehog signaling inhibitor cyclopamine16.=20 The expansion of normal human NPCs and human glioblastoma cells was also = inhibited by neuromodulators (Supplementary=20 Table 4 online). For example, PAPP and ifenprodil had = EC50 values=20 comparable to those of commonly used nonspecific brain tumor = chemotherapeutic=20 drugs, such as carboplatin and etoposide. Re-deployment of = well-tolerated=20 pharmacologically active agents may thus afford a new generation of=20 chemotherapeutic agents specific for brain tumor stem cells.

Figure=20 4: Neuromodulator drug sensitivity in normal and cancerous = NPCs.

(a) Ptch1+/- tumors contain cells = with=20 self-renewing neurosphere-forming potential in vitro. Scale bar, = 125 m.=20 (b) Ptch1+/- tumor cells stain positive (M1) = for the=20 early precursor marker prominin-1 (CD133 homolog) at levels comparable = to those=20 of primary human medulloblastomas (11.6%)29.=20 Unstained (black) and stained (red) specimens are shown. (c)=20 EC50 values (mean and s.d.) for inhibition of=20 Ptch1+/-Trp53-/- tumor sphere MTT=20 proliferation by various neuromodulators. Compound identity indicated in = Table=20 2. (d) RT-PCR gene expression profiles of a selection of=20 neurotransmitter receptors in different precursor populations. mRNA from = serum-differentiated neurospheres and mouse erythroid leukemia (MEL) = cells were=20 used as positive and negative controls, respectively. Vertical black = line=20 indicates noncontiguous lanes from the same experiment. (e) = Inhibition of=20 colony formation by bromocriptine in cultures with and without ()-sulpiride=20 supplementation. Normalized mean and s.e.m. values of three independent=20 triplicate cultures are shown. Sulpiride challenge significantly shifted = the=20 EC50 of bromocriptine from 1.2 M=20 (without sulpiride) to 2.5 M = (with=20 sulpiride) (P < 0.05), thereby indicating a rescue effect. = (f)=20 Representative micrographs of the inhibitory effects of bromocriptine on = NPC=20 expansion when challenged with a competitive antagonist. Scale bars, 500 = m.=20 (g,h) Functional ground state of NSCs: current models of = the NSC=20 hierarchy focus on developmental signaling pathways such as Wnt, Notch = and Sonic=20 Hedgehog (g); compounds identified in the HTS approach reveal = that the=20 NSC ground state and cell fate decision-making depend on a complex = circuitry=20 that includes many neurotransmission signaling pathways (h).

Full=20 figure and legend (97K)Figures,=20 schemes & tables index

As even well-characterized agents may exert biological = effects=20 through off-target pathways17,=20 we verified that a number of the known receptors for various agents are = indeed=20 expressed in both normal and tumor NPCs. The dopamine (DRD2), = acetylcholine=20 (M3), NMDA (NR1) and serotonin (5HT-1A) receptors were present in = primary and=20 secondary normal mouse neurosphere cultures and = Ptch1+/- tumor=20 neurosphere cultures, as determined by RT-PCR (Fig.=20 4d). In addition, we were able to use pharmacological inhibitors as = a means=20 to assess whether the growth inhibition caused by the dopamine class of=20 neuromodulators depends on transmission through a known receptor.

In one example, ()-sulpride=20 (Compound 17), a D2 dopamine receptor = antagonist, was=20 able to competitively rescue the inhibitory effects of the D2 and D3 = dopamine=20 receptor agonist bromocriptine (Compound 18), as judged by both colony = formation (Fig.=20 4e,f) and MTT values (data not shown). To further assess the = potential for=20 off-target effects of neuromodulators in other classes, we clustered the = 160=20 bioactive agents from the primary screen based on their chemical = structures (Supplementary=20 Table 1). This analysis demonstrated substantial chemical structural = diversity within each of the different neuromodulator classes. For = example, the=20 22 bioactive dopamine agents identified in the screen spanned 10 = different=20 structural motif clusters; similarly, the 12 active serotonergic agents = covered=20 10 different chemical clusters (Supplementary=20 Fig. 1 online). The observed sensitivity of NPCs to these = structurally=20 diverse agents is thus likely to arise through effects on known=20 neurotransmission receptors, as opposed to some unknown coincident = target.

The ex vivo and in situ manipulation of = NSCs for=20 treating neurological disorders, including brain cancer, will require an = understanding of the global signaling network that regulates NSC = behavior.=20 Through a chemical genetic approach we have uncovered the existence of a = complex=20 functional 'ground state', whereby NSC proliferation and self-renewal is = regulated by numerous signaling pathways (Fig.=20 4g,h). Importantly, this cohort includes many neurotransmission = pathways=20 previously thought to function only in mature cells of the CNS. = Therefore, we=20 infer that NSC proliferation and self-renewal requires an appropriate = local=20 environment of neurotransmitter activities, which may be provided by a = basal=20 level of autocrine feedback from more committed cells within the = neurosphere or=20 even the NSC itself. Indeed, recent studies on individual pathways = support the=20 notion that proliferation of different progenitor subpopulations in = vivo=20 may respond to dopamine, serotonin, acetylcholine and glutamate18.=20 Notably, our chemical genetic profile demonstrates the simultaneous = operation of=20 these pathways in NPCs cultured under uniform experimental conditions. = This=20 sensitivity of NPC cultures to a spectrum of neuroactive compounds also = supports=20 the notion of lineage priming in the NSC compartment, similar to that = seen in=20 hematopoietic stem cells19.

Though we have yet to definitively identify the = precursor=20 subpopulations targeted by each inhibitor identified in the screen, the = strong=20 selectivity of many agents for NPCs and primary brain tumor cells = suggests that=20 the affected pathways lie high in the hierarchical organization of the = neuronal=20 lineage. Indeed, the often complete inhibition of neurosphere = proliferation and=20 the effects on secondary replating suggest that stem cells and/or very = early=20 progenitor components of the population are affected by these agents. = The=20 finding that both inhibitors and activators of specific pathways inhibit = neurosphere proliferation (for example, dopamine receptor agonists and=20 antagonists) suggests that a complex signaling landscape dictates NSC=20 fate20.=20 We note that the pro-proliferative culture conditions used in the = neurosphere=20 assay may have biased the assay against identification of significant = numbers of=20 small molecules that stimulate proliferation. A small-molecule activator = of=20 embryonic stem cell proliferation has recently been identified21,=20 which suggests that analogous screens may succeed in identifying = activators of=20 NPC proliferation.

The unanticipated actions of well-characterized clinical = agents on=20 NPCs may account in whole or in part for the observed clinical benefits = of these=20 agents and/or the adverse side effects that arise after prolonged = therapy.=20 Effective in vivo concentrations of the anti-Parkinsonian drug=20 apomorphine reach 6=967 M<= A=20 href=3D"http://www.nature.com/nchembio/journal/v3/n5/full/nchembio873.htm= l#B22">22,=20 which is substantially higher than doses that affect NPCs in = vitro. Thus=20 the regulation of NSC proliferation by neurotransmitters may also = dictate how=20 the CNS is wired both during development and in the adult brain23.=20 Recent evidence suggests that appropriate GABA stimulation of NPCs is = required=20 for the proper integration of neurons in the adult hippocampus24.=20 Through structure-activity analysis, we also identified specific = chemical=20 substitutions that are important for the bioactivity of these agents in = our=20 in vitro system (Supplementary=20 Figs. 2 and 3=20 online). Such modifications to the core chemical structure of many = clinically=20 used agents may afford a way to regulate the potentially therapeutic or = harmful=20 effects these drugs have on NPCs.

In light of the evidence that CNS tumors are maintained = by cancer=20 stem cells1,3,=20 which have similarities to normal NSCs11,=20 the potent and selective antiproliferative agents identified in this = study may=20 presage a new generation of therapeutic agents in brain cancer, although = further=20 in vivo testing is required3.=20 Notably, a retrospective analysis of cancer incidence in individuals = with=20 Parkinson disease revealed a significant reduction in the incidence of = brain=20 tumors relative to the expected incidence in the general = population25;=20 this correlation may derive from the effect of anti-Parkinsonian drugs = on the=20 NPCs from which brain tumors are thought to arise. As the complex NSC = ground=20 state we propose is likely to at least in part define the identity of = brain=20 tumor stem cells, re-deployment of pharmacologically approved = neuroactive agents=20 may provide an immediate and nontoxic means to treat often intractable = CNS=20 tumors.

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Methods

Primary embryonic mouse NSC isolation and culture.

Isolation and culture of primary embryonic (e14.5) = mouse=20 NSCs was performed as previously described in chemically defined NSC=20 medium26=20 containing 20 ng ml-1 human recombinant epidermal growth = factor=20 (Sigma), 20 ng ml-1 basic fibroblast growth factor (Upstate) = and 2=20 g=20 ml-1 heparin (Sigma). Cells were fed every 2=963 d27.

Secondary mouse NSC neurosphere culture and chemical=20 screens.

Before chemical screens and other manipulations, = the NSC=20 fraction in culture was expanded by growing freshly dissected cells as = primary=20 neurospheres28=20 in bulk culture (106 cells ml-1). After 7 d, = primary=20 neurospheres were collected and enzymatically digested for 3 min at 37 = =B0C using=20 Accutase (Sigma), mechanically dissociated with a 1-ml pipette and = passed=20 through a cell strainer (Falcon). Viable cells were plated at low cell = densities=20 (20 cells l-= 1)=20 in 96-well plates (Falcon) in a final volume of 100 l and=20 screened in singlets against the LOPAC library (Sigma) at a = concentration of 3=20 M = (0.03%=20 DMSO). On day 4, each well in the screen was supplemented with an = additional 50=20 l of=20 fresh mouse NSC medium and another aliquot of the LOPAC library = (maintaining the=20 final concentration of each compound at 3 M).=20 Secondary neurosphere cultures were then incubated for an additional 3 d = (until=20 day 7), at which point the effect of each compound was assessed by = quantifying=20 the total proliferation of each well using the incorporation of the = vital dye=20 MTT (Sigma) as previously described29.

Statistical analysis for chemical screen.

Background plate effects (Supplementary=20 Methods) occurring from the evaporation of medium over the course of = the=20 experiment were estimated by:

3D"Unfortunately

where x'i,j is the value at well = i of=20 plate j, Nih is the number of = excluded hits=20 or outliers that were 2 s.d. below the mean, N is the total = number of=20 plates in the screen, and bi is the estimated=20 background at each well position30.=20 The respective background was then subtracted from the raw MTT value = measured=20 for each point (Supplementary=20 Methods). To calculate significance (z score and P = value), the=20 theoretical probability density function N(1.0, 0.11) was fitted = to the=20 empirical normalized distribution obtained from the screen (Supplementary=20 Methods). Compounds that caused optical density readings to = significantly=20 deviate from this predicted underlying distribution function (P = <=20 0.01) were designated as bioactive31.

Dose-response curves and EC50 = calculations.

Potency of confirmed bioactive compounds was = quantified by=20 generating dose-response curves for mouse NSC under the same cell = density and=20 culture conditions described for the initial screen. Starting from = initial=20 concentrations between 300 and 30 M, = each=20 compound was titrated across a series of ten half-log dilutions. Each = agent was=20 tested in triplicate in at least three independent experiments. = EC50=20 values for each agent were calculated by fitting the data points to the=20 four-parameter logistic sigmoidal dose-response curve:

3D"Unfortunately

where X is the logarithm of concentration and = Y is=20 the predicted response. Curve fitting was performed with GraphPad Prism = software=20 (GraphPad Software, Inc.).

Note: Supplementary=20 information and chemical=20 compound informationis available on the Nature Chemical Biology=20 website.

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Acknowledgments

We thank L. Lee, P. Northcode and S. Dolma for = technical=20 expertise, G. Giaever and C. Nislow for access to cheminformatics = software, and=20 S. Cordes for critical suggestions regarding pharmacological rescue = experiments.=20 P.D. is supported by a Canadian Institutes of Health Research (CIHR) = MD/PhD=20 studentship. P.B.D. is supported by grants from the National Cancer = Institute of=20 Canada, with funds from the Canadian Cancer Society, CIHR and the Stem = Cell=20 Network, and from donations from BrainChild and the Durigon (Jessica's=20 Footprint), Baker, Blyth and Kolic families. M.T. is supported by grants = from=20 the CIHR and a Canada Research Chair in Bioinformatics and Functional=20 Genomics.

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Ancillary details

Competing interests

The authors declare that they have no competing = financial=20 interests.

Received 14 September 2006; Accepted 14 March 2007; = Published=20 online 8 April 2007.

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References

  1. Galli, R. et al. Isolation and characterization of tumorigenic, stem-like = neural=20 precursors from human glioblastoma. Cancer=20 Res. 64, 7011=967021 (2004). | Article = ;| PubMed | ISI | = ;ChemPort |
  2. Hemmati, H.D. et al. = Cancerous stem cells can arise from pediatric brain = tumors.=20 Proc. Natl. Acad. Sci. USA 100, 15178=9615183 (2003). | Article |&nbs= p;PubMed | ChemPort |
  3. Singh, S.K. et al. Identification of human brain tumour initiating = cells. Nature 432, 396=96401=20 (2004). | Article&= nbsp;| PubMed | ISI | = ;ChemPort |
  4. Ahn, S. & Joyner, A.L. = In vivo analysis of quiescent adult neural stem = cells=20 responding to Sonic hedgehog. Nature=20 437, 894=96897 (2005). | Article&= nbsp;| PubMed | ISI | = ;ChemPort |
  5. Groszer, M. et al. PTEN negatively regulates neural stem cell self-renewal by = modulating G0=96G1 cell cycle entry. Proc. Natl.=20 Acad. Sci. USA 103, = 111=96116 (2006). | Article |&nbs= p;PubMed | ChemPort |
  6. Hitoshi, S. et al. Notch pathway molecules are essential for the maintenance, = but not=20 the generation, of mammalian neural stem cells. Genes Dev. 16,=20 846=96858 (2002). | Article | PubMed | ISI | = ;ChemPort |
  7. Lie, D.C. et al. Wnt=20 signalling regulates adult hippocampal neurogenesis. Nature 437,=20 1370=961375 (2005). | Article&= nbsp;| PubMed | ISI | = ;ChemPort |
  8. Molofsky, A.V. et al. = Bmi-1 dependence distinguishes neural stem cell = self-renewal from=20 progenitor proliferation. Nature 425, 962=96967 (2003). | Article&= nbsp;| PubMed | ISI | = ;ChemPort |
  9. Zhang, J.H., Chung, T.D. & = Oldenburg,=20 K.R. A simple statistical parameter for use in = evaluation and=20 validation of high throughput screening assays. J. Biomol. Screen. 4, 67=9673 (1999). | Article |&= nbsp;PubMed | ISI |
  10. Seifert, G., Schilling, K. = &=20 Steinhauser, C. Astrocyte dysfunction in = neurological=20 disorders: a molecular perspective. Nat. Rev.=20 Neurosci. 7, 194=96206 = (2006). | Article = ;| PubMed | ChemPort |
  11. Lee, J. et al. Tumor stem cells derived from glioblastomas cultured in = bFGF and EGF=20 more closely mirror the phenotype and genotype of primary tumors than = do=20 serum-cultured cell lines. Cancer = Cell=20 9, 391=96403 (2006). | Article |&n= bsp;PubMed | ChemPort |
  12. Phillips, H.S. et al. = Molecular subclasses of high-grade glioma predict = prognosis,=20 delineate a pattern of disease progression, and resemble stages in=20 neurogenesis. Cancer Cell = 9, 157=96173 (2006). | Article |&n= bsp;PubMed | ISI | = ;ChemPort |
  13. Taylor, M.D. et al. = Radial glia cells are candidate stem cells of = ependymoma.=20 Cancer Cell 8,=20 323=96335 (2005). | Article |&n= bsp;PubMed | ChemPort |
  14. Pomeroy, S.L. et al. = Prediction of central nervous system embryonal tumour = outcome based=20 on gene expression. Nature = 415, 436=96442 (2002). | Article = ;| PubMed | ISI | = ;ChemPort |
  15. Corcoran, R.B. & Scott, = M.P. A mouse model for medulloblastoma and basal cell nevus=20 syndrome. J. Neurooncol. 53, 307=96318 (2001). | Article |&nbs= p;PubMed | ChemPort |
  16. Berman, D.M. et al. = Medulloblastoma growth inhibition by hedgehog pathway=20 blockade. Science 297, 1559=961561 (2002). | Article |&nbs= p;PubMed | ISI | = ;ChemPort |
  17. Macdonald, M.L. et al. = Identifying off-target effects and hidden phenotypes of = drugs in=20 human cells. Nat. Chem. Biol. = 2, 329=96337 (2006). | Article&= nbsp;| 
  18. Hagg, T. Molecular=20 regulation of adult CNS neurogenesis: an integrated view. Trends Neurosci. 28,=20 589=96595 (2005). | Article |&= nbsp;PubMed | ChemPort |
  19. Enver, T. & Greaves, M. = Loops, lineage, and leukemia. Cell 94, = 9=9612 (1998). | Article = ;| PubMed | ISI | = ;ChemPort |
  20. Sharom, J.R., Bellows, D.S. = & Tyers,=20 M. From large networks to small molecules. = Curr. Opin. Chem. Biol. 8, 81=9690 (2004). | Article |&= nbsp;PubMed | ISI | = ;ChemPort |
  21. Chen, S. et al. Self-renewal of embryonic stem cells by a small = molecule.=20 Proc. Natl. Acad. Sci. USA 103, 17266=9617271 (2006). | Article |&nbs= p;PubMed | ChemPort |
  22. Butterworth, R.F. & = Barbeau, A. Apomorphine: sterotyped behavior and regional distribution = in rat=20 brain. Can. J. Biochem. 53, 308=96311 (1975). | PubMed | ChemPort |
  23. Lledo, P.M., Alonso, M. & = Grubb, M.S.=20 Adult neurogenesis and functional plasticity in = neuronal=20 circuits. Nat. Rev. Neurosci. = 7, 179=96193 (2006). | Article = ;| PubMed | ChemPort |
  24. Ge, S., Pradhan, D.A., Ming, = G.L. &=20 Song, H. GABA sets the tempo for activity-dependent = adult=20 neurogenesis. Trends Neurosci. = 30, 1=968 (2007). | Article |&= nbsp;PubMed | ChemPort |
  25. Lalonde, F.M. & = Myslobodsky, M. Are dopamine antagonists a risk factor for breast cancer? = An answer=20 from Parkinson's disease. Breast 12, 280=96282 (2003). | Article = ;| PubMed |
  26. Uchida, N. et al. = Direct isolation of human central nervous system stem = cells.=20 Proc. Natl. Acad. Sci. USA 97, 14720=9614725 (2000). | Article |&nb= sp;PubMed | ChemPort |
  27. Tropepe, V. et al. = Distinct neural stem cells proliferate in response to EGF = and FGF in=20 the developing mouse telencephalon. Dev.=20 Biol. 208, 166=96188 (1999). | Article | = ;PubMed | ISI | = ;ChemPort |
  28. Gritti, A. et al. = Epidermal and fibroblast growth factors behave as = mitogenic=20 regulators for a single multipotent stem cell-like population from the = subventricular region of the adult mouse forebrain. J. Neurosci. 19,=20 3287=963297 (1999). | PubMed | ISI | = ;ChemPort |
  29. Singh, S.K. et al. = Identification of a cancer stem cell in human brain = tumors.=20 Cancer Res. 63, 5821=965828 (2003). | PubMed | ISI | = ;ChemPort |
  30. Kevorkov, D. & = Makarenkov, V. Statistical analysis of systematic errors in = high-throughput=20 screening. J. Biomol. Screen. = 10, 557=96567 (2005). | Article |&nb= sp;PubMed |
  31. Chambers, J.M., Cleveland, = W.S., Kleiner,=20 B. & Tukey, P.A. Graphical Methods for = Data=20 Analysis (Chapman and Hall, New York, 1983).
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  1. The Arthur and Sonia Labatt Brain Tumor Research Centre, = The=20 Hospital for Sick Children and University of Toronto, 555 University = Avenue,=20 Toronto M5G 1X8, Canada.
  2. Program in Developmental and Stem Cell Biology, The = Hospital for=20 Sick Children and University of Toronto, 555 University Avenue, = Toronto M5G=20 1X8, Canada.
  3. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, = 600=20 University Avenue, Toronto M5G 1X5, Canada.
  4. Department of Medical Genetics and Microbiology, = University of=20 Toronto, 1 Kings College Circle, Toronto M5S 1A8, Canada.
  5. Department of Laboratory Medicine and Pathobiology, = Faculty of=20 Medicine, University of Toronto, Banting Institute, 100 College = Street,=20 Toronto M5G 1L5, Canada.
  6. Division of Neurosurgery, The Hospital for Sick Children = and=20 University of Toronto, 555 University Avenue, Toronto M5G 1X8, = Canada.

Correspondence to: Mike Tyers3,4=20 Email: tyers@mshri.on.ca

Correspondence to: Peter B Dirks1,2,5,6=20 Email: peter.dirks@sickkids.ca

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Nature Chemical Biology

ISSN: 1552-4450

EISSN: 1548-7105

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solid } #global-subject-areas H3.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #global-subject-areas 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HEIGHT: 600px; BORDER-RIGHT-WIDTH: 0px } DIV.ad-vert EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MAX-WIDTH: 120px! important; MARGIN: 4px 0px 0px; WIDTH: 100%; = HEIGHT: 600px; BORDER-RIGHT-WIDTH: 0px } * HTML DIV.ad-vert { MAX-WIDTH: 160px! important; MARGIN-LEFT: auto; OVERFLOW: hidden; = WIDTH: 100%; MARGIN-RIGHT: auto } .ad120x90 { CLEAR: both; FONT-SIZE: 80%; BACKGROUND: #fff; COLOR: #ccc; TEXT-ALIGN: = center } .ad120x90 IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; = BORDER-BOTTOM-WIDTH: 0px; MAX-WIDTH: 120px! important; MARGIN: 7px 0px; = WIDTH: 100%; HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .ad120x90 EMBED { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; MIN-HEIGHT: 90px; = BORDER-BOTTOM-WIDTH: 0px; MAX-WIDTH: 120px! important; MARGIN: 7px 0px; = WIDTH: 100%; HEIGHT: 90px; BORDER-RIGHT-WIDTH: 0px } .box#natjob { BORDER-RIGHT: #e7e7e7 1px solid; PADDING-RIGHT: 6px; BORDER-TOP: = #e7e7e7 1px solid; PADDING-LEFT: 6px; 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HTML UL.natjob UL { LINE-HEIGHT: 120% } DIV.natjobmore { PADDING-RIGHT: 0px; BORDER-TOP: #cecece 1px solid; PADDING-LEFT: 0px; = FONT-SIZE: 110%; PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-TOP: 5px } DIV.natjobmore A:link { DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/next.gif) no-repeat 0px 0.3em; MARGIN: 0px; = COLOR: #c03; TEXT-DECORATION: none } DIV.natjobmore A:visited { DISPLAY: inline; PADDING-LEFT: 15px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/icons/next.gif) no-repeat 0px 0.3em; MARGIN: 0px; = COLOR: #c03; TEXT-DECORATION: none } .box#natjob DIV.natjobmore A:hover { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); = TEXT-DECORATION: underline } .box#natjob DIV.natjobmore A:focus { BACKGROUND-IMAGE: url(/common/images/icons/next_hover.gif); = TEXT-DECORATION: underline } UL.natjob UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: 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