From: Subject: Intensity-Modulated Radiation Therapy Dose Prescription, Recording, and Delivery: Patterns of Variability Among Institutions and Treatment Planning Systems -- Das et al. 100 (5): 300 -- JNCI Journal of the National Cancer Institute Date: Thu, 10 Apr 2008 12:07:54 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0005_01C89B03.81BA8170" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://jnci.oxfordjournals.org/cgi/content/full/100/5/300 Intensity-Modulated Radiation Therapy Dose = Prescription, Recording, and Delivery: Patterns of Variability Among = Institutions and Treatment Planning Systems -- Das et al. 100 (5): 300 = -- JNCI Journal of the National Cancer Institute

Skip=20 Navigation

=20
  • Contact=20 Us
  • My=20 Basket
  • My=20 Account

JNCI Journal of the = National Cancer=20 Institute

  • About = This=20 Journal
  • Contact = This=20 Journal
  • Sub= scriptions=20
  • Current=20 Issue
  • Archive=
3D"left Previ= ous=20 Article | Next = Article 3D"right=20

Journal of=20 the National Cancer Institute Advance Access originally published online = on=20 February 26, 2008
JNCI=20 Journal of the National Cancer Institute 2008 100(5):300-307;=20 doi:10.1093/jnci/djn020
This = Article
3D"
3D"Right Ab= stract=20 3D"Freely
3D"Right FRE= E=20 Full Text (PDF) 3D"Freely
3D"Right Suppl= ementary=20 Figure
3D"Right OA All = Versions=20 of this Article:
100/5/300    most recent
djn020= v1=20
3D"Right Alert = me when this article is cited
3D"Right Aler= t=20 me if a correction is posted
3D"
Services
3D"
3D"Right Email=20 this article to a friend
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in ISI Web of Science
3D"Right Similar=20 articles in PubMed
3D"Right Alert me to=20 new issues of the journal
3D"Right Add=20 to My Personal Archive
3D"Right D= ownload=20 to citation manager
3D"Right Request=20 Permissions
3D"
Google = Scholar
3D"
3D"Right Articles by Das, I. J. =
3D"Right Articles by Glatstein, E. =
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Das, I. J. =
3D"Right Articles by Glatstein, E. =
3D"
Related = Collections
3D"
3D"Right Editorial=20 about this Article
3D"Right Related=20 Article in JNCI
3D"
Social = Bookmarking
3D"
3D"         
What's = this? =

=A9=20 2008 The Author(s).
This is an Open Access article distributed under = the=20 terms of the Creative Commons Attribution Non-Commercial License=20 (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits = unrestricted=20 non-commercial use, distribution, and reproduction in any medium, = provided the=20 original work is properly cited.

ARTICLES

Intensity-Modulated Radiation Therapy Dose Prescription, Recording, = and=20 Delivery: Patterns of Variability Among Institutions and Treatment = Planning=20 Systems

Indra J. Das, Chee-Wai = Cheng,=20 Kashmiri L. Chopra, Raj K. Mitra, Shiv = P.=20 Srivastava, Eli Glatstein=20

Affiliations of authors: Department of = Radiation=20 Oncology, University of Pennsylvania, Philadelphia, PA (IJD, EG); = Department of=20 Radiation Oncology, Morristown Memorial Hospital, Morristown, NJ (CWC);=20 Department of Radiation Oncology, Kennedy Health System, Sewell, NJ = (KLC);=20 Department of Radiation Oncology, Ochsner Clinic Foundation, New = Orleans, LA=20 (RKM); Department of Radiation Oncology, Reid Hospital & Health Care = Service, Richmond, IN (SPS)

Correspondence to: Indra J. Das, FACR, = Department of=20 Radiation Oncology, University of Pennsylvania, 2 Donner Bldg, 3400 = Spruce St,=20 Philadelphia, PA 19104 (e-mail: das{at}xrt.upenn.edu ).


3D"    ABSTRACT
Top
3D"Abstract
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Context and Caveats
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Subjects and Methods
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Results
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Discussion
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>References
Notes
 
Backgr= ound:=20 Intensity-modulated radiation therapy (IMRT) is a widely accepted=20 method for radiation treatment to provide a prescribed and = uniform=20 dose to the target volume and a minimum dose to normal = tissues=20 that is dependent on the IMRT software and the treatment = machine.=20 We examined the variation in IMRT dose prescription, = treatment=20 planning, dose recording, and dose delivery among cancer = patients=20 who were treated with different treatment planning systems at = different medical institutions to assess variability in = patient=20 care.

Methods: We conducted a retrospective analysis of 803 patients who = were=20 treated with IMRT between October 2004 and July 2006 for = brain,=20 head and neck, or prostate cancer at five medical = institutions=20 that used different treatment planning systems. The = prescribed=20 dose to the target volume, as recorded in the chart or as = noted=20 in the electronic data management system, was extracted for=20 each patient. The planned dose that was delivered to the = patient,=20 as represented in the dose=96volume histogram, was acquired = from=20 each treatment planning system. The actual minimum, maximum, = median,=20 and isocenter doses to the target volume were normalized to = the=20 prescribed dose and analyzed for each disease site and=20 institution.

Results: Of the 803 patients, 12% were treated for brain cancer, = 26%=20 for head and neck cancer, and 62% for prostate cancer. The = recorded=20 dose variability from prescription was widespread for the = minimum,=20 maximum, and isocenter doses. A total of 46% of the patients=20 received a maximum dose that was more than 10% higher than = the=20 prescribed dose, and 63% of the patients received a dose that = was more than 10% lower than the prescribed dose. At all five = institutions, the prostate cancer cases had the smallest = dosimetric=20 variation and the head and neck cancer cases had the largest=20 variation. The median dose to the target varied from the = prescribed=20 dose by =B12% in 68% of the patients, by =B15% in 88% = of the=20 patients, and by =B110% in 96% of the patients. The recorded = isocenter=20 dose varied from prescription for all disease sites and = treatment=20 planning systems.

Conclusions: Substantial variation in the prescribed and delivered = doses=20 exists among medical institutions, raising concerns about the = validity of comparing clinical outcomes for IMRT. The = isocenter=20 dose in IMRT is simply a point dose and often does not = reflect=20 the prescription dose that is specified by a selected isodose = line encompassing the target volume. This study suggests the=20 need for national and/or international guidelines for dose=20 prescription, planning, and reporting for a meaningful = clinical trial=20 in IMRT.



  =20 CONTEXT AND CAVEATS
Top
Abstract
3D"Context and = Caveats
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Subjects and Methods
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Results
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Discussion
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>References
Notes
 
Prior=20 knowledge

Intensity-modulated radiation therapy (IMRT) is = widely used=20 to treat cancer because it provides a prescribed and = uniform=20 radiation dose to the target while minimizing the = radiation=20 dose to normal tissues. In IMRT, many factors, including=20 special software, are required to plan treatments and = control=20 the radiation dose during therapy. Variations in these = factors=20 can affect the dose and, consequently, the clinical outcome.

Study design

A retrospective analysis of treatment parameters for = 803=20 patients who were treated with IMRT for brain, head and = neck,=20 or prostate cancer at five medical institutions that used=20 different treatment planning systems.

Contribution

In IMRT, the prescribed dose rarely corresponded to = the=20 planned, or delivered, dose. At all five institutions,=20 dosimetric variation was smallest for the prostate = cancer cases=20 and largest for the head and neck cancer cases. The = recorded=20 delivered dose varied from the prescribed dose for all = disease=20 sites and treatment planning systems.

Implications

The substantial variation in the prescribed and = delivered=20 doses that exists among medical institutions raises = concerns=20 about the validity of comparing clinical outcomes for = IMRT.=20 National and/or international guidelines for dose = prescription,=20 planning, and reporting in IMRT are needed.

Limitations

The medical institutions differed with respect to = volume=20 delineation, the availability of quality-assurance data = for the=20 treatment planning algorithms, and the uniformity of = IMRT input=20 constraints. Only five treatment planning systems from = five=20 institutions, some of which had limited IMRT planning = data in=20 certain disease sites, were included.

 

An improvement in radiation therapy outcomes could be achieved = by=20 periodic comparisons of clinical practices through outcome=20 evaluations from clinical trials and studies. For a = multicenter=20 study, a meaningful comparison of clinical outcomes in = response=20 to radiation treatment requires a standardized process for = dose=20 specification. Treatment outcome can be interpreted = meaningfully=20 only with accurate knowledge of the reference dose and the = dose=20 distribution. National guidelines for clinical reference = dosimetry,=20 such as those put forth by Task Groups 21 and 51 of the = Radiation=20 Therapy Committee of the American Association of Physicists = in=20 Medicine (1= ,2= ),=20 recommend that the reference dose (machine output) should not = vary by=20 more than =B12% among centers. For patient treatment, the = combined=20 dosimetric uncertainty in the target volume (which includes=20 differences in patient setup and localization, machine = calibration,=20 and dose calculation) should be at least within =B15%. Dische = et al.=20 (3= )=20 showed that a dose difference as small as =B15% may lead to = a=20 real impairment or enhancement of tumor response as well as = a=20 change in the risk of morbidity to the normal tissues. The = variation=20 in dose specification was first recognized as a problem in = 1978, when=20 the International Commission on Radiation Units and = Measurements=20 (ICRU) provided guidelines for dose specification to the = target=20 volume in ICRU Report 29 (4= ).=20 This report was replaced in 1993 by ICRU Report 50 (5= ),=20 which included the concepts of target volume, gross target = volume,=20 and clinical target volume (CTV) and clearly defined the = planning=20 target volume (PTV) and organs at risk. Additional = modifications of=20 these concepts were added in ICRU Report 62 (6= ).=20 The ICRU guidelines provided a standard approach to delineate = target=20 volumes and specify radiation dose to facilitate intra- and=20 interinstitutional comparisons of treatment parameters for = clinical=20 outcomes in patients treated with three-dimensional conformal = radiation therapy (3D-CRT) worldwide. On the basis of = clinical=20 outcome data from patients with breast and prostate cancer, = ICRU-50=20 (5= )=20 recommended a uniform dose to the target volume within =965% = to +7% of=20 the prescribed dose, which was clinically feasible at that = time.=20 Traditionally, however, =B110% variation from the prescribed = dose is=20 an accepted norm in most clinical practices and is widely = used=20 in IMRT.

Great importance was given by the ICRU to the isocenter in = 3D-CRT=20 because the machine isocenter (ie, the intersection of the = axis=20 of rotation of the machine gantry, the collimator, and the = treatment=20 table) can be placed within the target to within =B12 mm = for most=20 linear accelerators as recommended by TG-40 guidelines (7= ). In=20 3D-CRT, the isocenter is usually the geometric center of the = target=20 volume where dose is prescribed and recorded. In IMRT, = however, the=20 isocenter can be placed anywhere inside the treated volume, = including=20 those locations that may be near a low-dose region or inside = an organ=20 at risk, and is mainly used for positioning the patient in = the=20 machine, which is critical for dose delivery. ICRU-50 (5= )=20 recommended that the radiation dose be documented at the = reference=20 point, which is generally the isocenter. Mijnheer (8= )=20 pointed out some differences between current practices and = ICRU-50=20 dose specifications. However, it has been generally accepted = that in=20 3D-CRT, the mean dose to the target and the ICRU reference = dose are=20 directly correlated with a SD of less than 2% in most disease = sites=20 (9= ).=20

The emergence of intensity-modulated radiation therapy (IMRT) = from=20 nascent technology in the 1980s (= 10=96= 12)=20 to a well-established modality within just 10 years has = opened the=20 doors to its widespread use in the radiation oncology = community (= 13=96= 15).=20 An informal survey that we conducted indicates that, = depending on the=20 institution, 30%=9660% of cancer patients in the United = States are=20 currently being treated with IMRT. IMRT uses inverse planning = to=20 generate beamlets (subfield) that produce a variable dose = intensity=20 map, whereas 3D-CRT uses forward planning to produce a = uniform=20 field of dose intensity. The difference between IMRT and = 3D-CRT=20 planning (inverse vs forward planning) is analogous to the=20 difference between bargaining and fixed-price shopping. That = is, in=20 IMRT, a treatment planner submits the desired constraints in=20 terms of a cost function and compromises on the outcome=20 (bargains for the price to pay), whereas in 3D-CRT the = prescription=20 dose is fixed and the treatment planner directly calculates = the=20 input parameter (monitor units) for each treatment field. In=20 IMRT, one usually does not get exactly what is being = bargained=20 for (ie, the exact dose distribution as prescribed), but a = good=20 treatment planner, like a good bargainer, can get fairly = close=20 to the desired initial goal (ie, the desired dose to the = target=20 volume while achieving a minimum dose to the adjacent normal=20 tissues). In general, the inverse planning process with = current=20 treatment planning systems may not always produce the exact=20 solution but can produce a solution that is close enough to=20 achieve the treatment goals based on the desired constraints. = In IMRT, the solution to the cost functions is = multifactorial,=20 depending on the complexity of the target and organs at risk. = It is not uncommon in radiation therapy to settle on a lower=20 coverage to the PTV to limit the radiation dose to organs at=20 risk. Hence, IMRT planning is more of an art to achieve a = compromise=20 solution to the cost function with applied constraints. In = IMRT,=20 what is being prescribed may not be achieved exactly by the=20 treatment planning process, an outcome very similar to the = bargaining=20 process. The difference between the prescribed and the = planned=20 (or delivered) dose is dependent on the treatment planning = system=20 and institution and also, more importantly, on the nature and = location of the overlapping structures among targets and = organs=20 at risk.

The clinical outcome, such as survival and local control, of=20 patients treated with radiation is related to the tumor = control=20 probability (TCP), which improves with multimodality imaging=20 for precise tumor delineation, a better knowledge of the = normal=20 tissue complication probability (NTCP) (= 16,= 17),=20 and with greater attention to patient positioning, total = dose, and=20 dose per fraction. IMRT produces a steep radiation dose = gradient=20 around the tumor, thus creating a therapeutic advantage that = cannot=20 be achieved with conventional 3D-CRT. IMRT uses beamlets or = segments=20 via multiple coplanar and noncoplanar treatment fields,=20 depending on the delivery technique and optimization goal. = IMRT also=20 requires an absolute reliance on either cumulative or = differential=20 dose=96volume histograms for the tumor and the organs at = risk, which=20 provide information on the dose=96volume relationships that = are=20 calculated based on user-defined constraints. Such changes = have=20 created an additional adjustment to our thinking from the = 3D-CRT=20 concept, where dose is defined to a point. Nonetheless, = although=20 3D-CRT was developed to provide a uniform dose to a volume, = the=20 dose is actually recorded at a point (5= ). In=20 addition to requiring attention to such complex issues as = patient=20 immobilization, improved volume delineation, organ motion = control,=20 and dose delivery, IMRT also requires that the prescribed = dose to a=20 volume takes into account tissue tolerance constraints, which = are=20 dependent on the total delivered dose.

IMRT optimization results in different shapes of the = dose=96volume=20 histogram, depending on the treatment planning system = algorithm,=20 the beam characteristics of the multileaf collimator (eg,=20 double-focus vs curved-end, 1-cm vs 0.5-cm leaf width), organ = constraints, and segmentation parameters, such as the number = of beam=20 segments and the dose intensity levels as implemented based = on=20 institutional or physician-prescribed guidelines. Although = the=20 concept of isocenter in IMRT is still valid in the context of = patient=20 setup, its use as a dose specification point (8= ) has=20 become meaningless due to variable dose specification to the = volumes.=20 Furthermore, the radiobiologic consequences for differential = dose and=20 dose per fraction as performed in concomitant boost treatment = through IMRT require further evaluation and serious = consideration=20 because the TCP for a nonuniform target dose is reduced=20 substantially (= 18,= 19).=20 These issues raise substantial concerns that need to be = addressed=20 through additional international guidelines in the form of = ICRU=20 recommendations for IMRT treatment.

As previously reported (= 20),=20 the shape of a dose=96volume histogram for treatment can vary = substantially from one patient to another and also from one = treatment=20 planning system to another. As a result, dose specification,=20 reporting, and recording could differ substantially among = different=20 institutions, thus potentially affecting comparisons of = clinical=20 outcomes. The goal of this study was to examine the variation = in IMRT=20 treatment planning, dose distribution, and dose delivery = among=20 different institutions in terms of the accepted minimum, = maximum, and=20 median doses in treatment volume from the optimal plan and = the=20 resulting dose to the isocenter. We focused on minimum, = maximum, and=20 median dose parameters rather than on the volume of the PTV = that=20 received 99%, 95%, and 90% of the prescribed dose because the = dose=20 parameters are readily available for all treatment planning = systems.=20 Our goal was not to determine whether one institution or=20 treatment planning system was superior to another but rather = to=20 identify common characteristics regarding the use of IMRT = from a=20 variety of clinical practices and dose optimization = algorithms and=20 to determine how dose prescription and the planning dose = differs=20 among institutions.


3D"   =20 Subjects and Methods
Top
Abstract
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Context and Caveats
3D"Subjects and Methods
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Results
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Discussion
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>References
Notes
 
Five=20 institutions participated in this study=97University of = Pennsylvania=20 (Philadelphia, PA), Morristown Memorial Hospital (Morristown, = NJ),=20 Kennedy Health System (Sewell, NJ), Ochsner Clinic Foundation = (New=20 Orleans, LA), and Reid Hospital & Health Care Service = (Richmond,=20 IN). The participating institutions include a broad range of=20 radiation oncology departments in terms of the number of = machines=20 they possess, the number of staff, the number of patients = treated per=20 day, and the type of practice (academic vs community based). = Each of=20 these institutions uses a different IMRT treatment planning = system:=20 BrainScan (BrainLab, Feldkirchen, Germany), CMS-XiO (CMS Inc, = St=20 Louis, MO), Eclipse (Varian Medical System, Palo Alto, CA), = Oncentra=20 (Nucletron V.B., Veenendaal, The Netherlands), and Pinnacle = (Philips=20 Medical Systems, DA Best, The Netherlands). All patients in = this=20 study were sequentially selected from each institution and = were=20 treated with IMRT between October 2004 and July 2006. The = data=20 were collected in full compliance with the Health Insurance=20 Portability and Accountability Act requirements. Proper = guidelines=20 were followed for the institutional review board (IRB) at the = University of Pennsylvania. This study qualified for = exemption from=20 review by the IRB as granted under the US Department of = Health=20 and Human Services policy for protection of human subjects 45 = CFR 46.101(b) Section 4. Accordingly, only information that = was=20 devoid of patient identifiers and demographics and relevant = to=20 this study, such as disease site, treatment plan, and dose=20 parameters, was entered into the study database sequentially=20 from each institution. For this study, we collected treatment = planning data for 803 patients who had undergone IMRT for = brain,=20 head and neck, or prostate cancer at one of the five = participating=20 institutions. The distribution of patients by treatment = planning=20 system and disease site is shown in T= able=20 1. Some institutions had only limited planning data for = one or=20 more disease sites. The type of IMRT cases from each = institution=20 reflects the typical clinical practice at the time when the = patients=20 were treated and data were collected.


View = this=20 table:
[= in=20 this window]
[in a new window]

  = 		Table 1. = Distribution of=20 patients by treatment planning system and disease site =

 = ;
Each=20 of the treatment planning physicists (IJD, CWC, KLC, RKM, = SPS) had=20 planned treatment for a minimum of 50 IMRT cases and = therefore was=20 considered to be an experienced planner. In this = retrospective study,=20 the prevailing institutional IMRT standards were respected = and no=20 attempt was made to modify or alter the treatment plans or = the=20 clinical practices. The prescription dose to the target = volume=20 (primarily the PTV and the CTV) that was recorded in the = chart or=20 noted in the record-and-verify system (ie, an electronic data = management system that keeps track of every treatment = parameter=20 during the entire treatment) was extracted for each patient. = The=20 treatment plan for each patient in this study was reviewed by = a=20 physician and a physicist at each institution. For each = patient, we=20 extracted the minimum, maximum, and median doses in the = target volume=20 and the isocenter dose from the planned dose=96volume = histogram that=20 was used to treat the patient. The IMRT treatment plans that = are=20 delivered to the patients cannot be verified directly. The=20 verification process is performed indirectly on a = tissue-equivalent=20 phantom by direct measurements of the point dose and dose=20 distribution of the patient's plan. Accordingly, all patients = in this=20 study were verified indirectly by the in-phantom measurements = for the accuracy criterion of IMRT dose delivery to an = accuracy=20 of =B15% and spatial agreement of planned to delivered = isodose=20 lines of =B13 mm. The phantom measurement provides a link = between=20 prescription and the dose delivery and is a measure of = quality=20 assurance in IMRT. The maximum, minimum, and median doses in = the=20 target volume provide a crude estimate of the slope of the=20 dose=96volume histogram curve, which defines the quality of = the=20 treatment plans included in this study. Even though the = dose=96volume=20 histogram does not provide spatial information about hot and = cold=20 spots (ie, doses higher than 100% in organs at risk and lower = than=20 100% in target volume, respectively) unlike the spatial = dose=96volume=20 histogram as defined by Cheng and Das (= 21),=20 it has become customary to use the dose=96volume histogram = for IMRT=20 optimization and hence it was used in this study. The data = presented=20 here reflect the institutional IMRT constraints for patient = treatment=20 that has been achieved for the best possible plans by the=20 individual planner.

Retrospectively collected data for all 803 patients were = analyzed=20 by normalizing the maximum, minimum, median, and isocenter = doses=20 to the prescribed dose (defined as 1.0). Dosimetric = deviations=20 from the prescribed dose expressed as a percentage were = grouped=20 by disease site, treatment planning system, and =B110% = dose=20 intervals (ie, dose deviation bins) for comparison and = analysis.=20


3D"   =20 Results
Top
Abstract
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Context and Caveats
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Subjects and Methods
3D"Results
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>Discussion
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>References
Notes
 
F= igure=20 1 shows the variation in dosimetry among the 803 patients = treated=20 with IMRT at the five institutions. This plot is a normalized = dose=20 plot that reflects the extent of the variation independent of = the=20 prescribed dose, which varied among the three disease sites = and among=20 the five institutions (for unnormalized dose plots, see = Supplementary=20 Figure 1, available online). The typically accepted IMRT dose = variation of =B110% is also shown by the lines drawn at the = y-axis at=20 1.1 and 0.9. The maximum, minimum, median, and isocenter = doses to the=20 prescribed target volume showed wide variations among the = patients.=20 These doses also varied widely by more than =B110% in = individual=20 patients, as reflected by the minimum and maximum doses in = the=20 target volume. For example, 46% of the patients received a=20 maximum dose that was more than 10% higher than the = prescribed=20 dose, and for some it was as high as 40% higher than the=20 prescribed dose. On the other hand, 63% of the patients = received a=20 dose that was less than 10% lower than the prescribed dose, = and=20 a portion of the target received a dose close to 0%. The=20 abnormally low dose (ie, <0.9; F= igure=20 1) in the target volume reported by the minimum dose = could be=20 primarily attributed to the target volume being located close = to=20 surface or in the buildup region and/or to the presence of an = overlapping structure that was planned as an organ at risk in = dose=20 optimization. Some treatment planning systems provide = sophisticated=20 algorithms that can treat the overlapping structures, in = terms of the=20 intersection and union of volumes, either as a target or an = organ at=20 risk with appropriate weights in IMRT optimization. Such a = decision,=20 however, is institution and physician dependent and usually=20 requires consultation with the planning team. The weighting=20 priorities should be evaluated for each patient based on the=20 structures involved. If an increase in the minimum target = dose is=20 required (ie, to a dose that is close to the prescribed = dose), then=20 attention should be given to the delineation of PTV by = avoiding=20 buildup region and overlapping structures. A well-designed = study=20 is needed to evaluate how issues such as location, margin,=20 overlap, and weight affect the quality of treatment = plan.


<= IMG=20 height=3D115 alt=3D"Figure 1" hspace=3D10=20 = src=3D"http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/= jncidjn020f01_4c.gif"=20 width=3D200 vspace=3D5 border=3D2>
View = larger=20 version (35K):
[= in=20 this window]
[in a new window]
[Do= wnload=20 PowerPoint slide]
  		Figure 1. = Dosimetric=20 variations between the prescribed and planned doses among = 803=20 patients from five medical institutions with different = treatment=20 planning systems. Vertical lines separate the data = according=20 to treatment planning system (from left to right: Oncentra,=20 BrainScan, Pinnacle, CMS-XiO, Eclipse). The horizontal = line=20 at 1.0 represents no dose deviation; the horizontal = lines at=20 1.1 and 0.9 represent dose deviations of +10% and =9610%,=20 respectively, between the planned dose and the prescribed = dose. =

 = ;
The=20 large dosimetric variation reflected in F= igure=20 1 shows the patterns of dose deviation from prescription = as=20 determined by a planned dose=96volume histogram in IMRT. Such = wide=20 variations in dose planning and delivery suggest that it may = not be=20 meaningful to compare clinical outcomes among IMRT patients = treated=20 at different institutions. The median dose in the target = volume=20 exhibited the smallest variation among the 803 patients. The=20 median dose varied from the prescribed dose by =B12% in = 68% of=20 the patients, by =B15% in 88% of the patients, and by =B110% = in 96% of=20 the patients. In contrast, the isocenter dose, which the = ICRU-50=20 recommends be documented, showed substantially greater = variation=20 among the 803 patients (F= igure=20 1). Even though institutional variations differed = somewhat=20 because of differences in disease site distribution, the = pattern in=20 F= igure=20 1 shows clear evidence of wide dosimetric variation in = radiation=20 treatments using IMRT.

We next examined the frequency of dosimetric variation among = the=20 different treatment planning systems according to disease = site (ie,=20 head and neck, brain, and prostate). For each disease site = and=20 treatment planning system, the maximum and minimum doses were = treated=20 as separate entities and were grouped according to the = percent=20 difference from the prescribed dose (ie, dose deviation bin) = for=20 plotting. The frequency distributions of the patients in = various dose=20 deviation bins by treatment planning system are shown in F= igure=20 2. The dashed line at zero separates the minimum and = maximum dose=20 bins. In general, the dose spread was more pronounced in the = low-dose=20 region than in the high-dose region. The dosimetric = spread=97which=20 reflects the greater overlap between the target volume and = the normal=20 structure(s), low-priority structures, or targets within = targets in=20 these patients=97was greatest for the head and neck cancer=20 patients, smaller for the brain cancer patients, and smallest = for=20 the prostate cancer patients. The dosimetric deviations from = the=20 accepted =B110% dose range were 77%, 60%, and 49% for the = head=20 and neck, brain, and prostate cancer patients, respectively. = F= igure=20 2 also shows that the prescribed dose and the planned = and/or=20 delivered dose were never in agreement=97that is, the dose = bin at zero=20 had no cases. It is obvious that the prescribed dose = constraints were=20 rarely met in the final dose calculation. If the constraints = had been=20 fully met, the highest values in the frequency distribution = would=20 have been near the zero-dose bin. The large frequency spread=20 reflected in dosimetric variation, as shown in F= igure=20 2, illustrates how difficult it is to record the true = delivered=20 dose in IMRT. Such a large deviation from prescription in = 3D-CRT=20 would have been reported as a misadministration. In IMRT, = however,=20 misadministration based on dose deviation is not recognized = and is=20 accepted as the result of dose optimization.


<= IMG=20 height=3D200 alt=3D"Figure 2" hspace=3D10=20 = src=3D"http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/= jncidjn020f02_4c.gif"=20 width=3D103 vspace=3D5 border=3D2>
View = larger=20 version (24K):
[= in=20 this window]
[in a new window]
[Do= wnload=20 PowerPoint slide]
  		Figure 2. = Frequency=20 distribution of the dose differences (prescribed vs planned) = among=20 various treatment planning systems for patients with = (A)=20 prostate cancer, (B) head and neck cancer, and = (C)=20 brain cancer. The dose difference bin is defined as the = difference=20 between prescribed and planned dose from maximum and minimum = doses=20 and grouped in dose bins for all 803 patients. The dotted = line at 0% indicates that the prescribed dose and the = planned=20 dose are the same. =

 = ;
The=20 variation in IMRT cost function optimization and final calculated=20 dosimetric results depends on treatment planning systems and = on=20 the calculation algorithms that handle inhomogeneity correction. = All=20 patients included in this study were treated according to a = treatment=20 plan that adhered to the individual institutional guidelines; = however, inhomogeneity corrections in optimization and dose=20 calculations were properly accounted for based on verification = and=20 commissioning data for institutional IMRT. F= igure=20 3 shows the percentage of the patient population = (frequency=20 distribution) for which the prescribed dose deviated from the = planned=20 dose within =B110% according to treatment planning system = and=20 disease site. We found an acceptable =B110% dose variation=20 between prescribed and delivered dose only in 11%, 49%, 39%,=20 81%, and 80% of prostate cancer patients treated with the = Oncentra,=20 BrainScan, CMS-XiO, Pinnacle, and Eclipse treatment planning=20 systems, respectively. By contrast, we found an acceptable = =B110%=20 dose variation between prescribed and delivered dose in 20%,=20 21%, and 36% of head and neck cancer patients treated with = the=20 Oncentra, BrainScan, and CMS-XiO treatment planning systems,=20 respectively. The frequency distribution could indirectly = indicate=20 the relative advantages of different treatment planning = systems.=20 For example, for the prostate cancer patients, the Pinnacle = and=20 Oncentra treatment planning systems provided a dose that = exceeded the=20 =B110% dose criterion to nearly 20% and 80% of the patient = population,=20 respectively. Hence, it appears that that the Pinnacle system = provides an IMRT treatment plan that is superior to that = provided by=20 the Oncentra system. However, such a quick conclusion without = a=20 quantitative evaluation of the different planning systems is = not=20 reliable because of the multitude of dose=96volume histograms = for=20 targets and organs at risk and the differences in = optimization and=20 dose calculation algorithms (= 17).=20


<= IMG=20 height=3D132 alt=3D"Figure 3" hspace=3D10=20 = src=3D"http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/= jncidjn020f03_lw.gif"=20 width=3D200 vspace=3D5 border=3D2>
View = larger=20 version (18K):
[= in=20 this window]
[in a new window]
[Do= wnload=20 PowerPoint slide]
  		Figure 3. = Percentage of=20 patient population within =B110% dose variation (planned vs=20 prescription) for different disease sites and treatment = planning=20 systems. Histograms shown are for the treatment planning = systems=20 that were used to treat patients with cancers at all three = disease=20 sites. =

 = ;

3D"   =20 Discussion
Top
Abstract
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Context and Caveats
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Subjects and Methods
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Results
3D"Discussion
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/darrow.gif" = width=3D11=20 border=3D0>References
Notes
 
IMRT = has been=20 shown to provide superior dose distribution for organs at = risk=20 compared with 3D-CRT, and hence it has a greater potential to = improve=20 the therapeutic ratio and, possibly, to reduce the toxic = effects to=20 normal tissues (= 15).=20 However, in our collective experience, the relatively wider = shoulder=20 of the dose=96volume histogram for the target volume for = IMRT=20 compared with 3D-CRT suggests that IMRT may result in poor = and=20 inhomogeneous target coverage. This pattern of a wider = shoulder=20 in the dose=96volume histogram (spread in maximum and minimum = dose) is reflected in the variation in dose delivery as shown = in F= igure=20 1 and has also been reported by various investigators (= 22,= 23)=20 for head and neck cancer. Boyer et al. (= 22)=20 reported underdosage in the range of 15%=9650% and overdosage = in=20 the range of 25%=9657%, and Zhou et al. (= 23)=20 reported an overdosage of 23%. Vineberg et al. (= 24)=20 also acknowledged the large dosimetric variation between = prescription=20 and planning in IMRT and suggested modifying cost functions = and=20 treatment planning systems. To our knowledge, no similar = studies=20 have been reported for dose variation in the literature for=20 3D-CRT, except for the large dosimetric deviations that are=20 reported as misadministration. We found that in IMRT the = prescribed=20 dose rarely corresponded to the planned, or delivered, dose = (F= igure=20 2). Thus, recording the delivered dose becomes inaccurate = and=20 ambiguous with respect to the prescribed dose. To eliminate = the=20 large variations between the prescribed dose and the = delivered=20 dose, a consensus effort by the radiation oncology community = and=20 guidelines from national and international radiation = organizations=20 are required.

Initial enthusiasm about the better efficacy of IMRT compared = with=20 3D-CRT has also been criticized as premature due to the lack = of=20 clinical outcome data (= 25).=20 Clinical outcomes are complex issues that depend on the = dose=96volume=20 relationships in the target volume and the organs at risk and = require=20 long-term follow-up for the data to mature fully. Some of the = problems associated with the radiation outcome may also be=20 attributed to the lack of specific dose guidelines for IMRT = outside=20 of a few nationally accepted clinical protocols, such as = those=20 endorsed by the Radiation Therapy Oncology Group (http://www.rtog.org/). = Thus, each=20 clinic has its own criteria of plan acceptability and dose = recording=20 for IMRT that may vary by disease site. This study suggests = that the=20 difference between the prescribed dose and the delivered dose = is less=20 pronounced in the prostate cancer cases than in head and neck = or=20 brain cancer cases for all treatment planning systems (F= igures=20 2 and 3= ).=20 This is due to multiple structures with competing constraints = producing stricter criterion for optimization, depending on = the=20 treatment planning system. There are no existing guidelines = on what=20 the shape of the dose=96volume histogram should be nor do we = have a=20 method to compare data from one institution with that from = another=20 institution with the same input constraints. This study = clearly shows=20 that wide variations between the prescribed dose and the = delivered=20 dose exist for patients who receive IMRT through different=20 treatment planning systems. This variability should be = further=20 examined in the context of the dose per fraction and the = total=20 prescribed dose. For example, a maximum dose in the target = volume=20 that is 30% higher than the prescribed dose could signify = that=20 the dose per fraction is not the 2 Gy/day that was intended = but=20 rather 2.6 Gy/day, which could result in an entirely = different=20 clinical outcome. A similar situation could exist in the = normal=20 tissues, where the actual dose could be higher than the = intended=20 prescribed dose with possible unexpected complications. =

Another reason why it is difficult to compare outcome data is=20 because, for most disease sites, target volume delineation = varies=20 so much from one institution to the other (= 26=96= 32).=20 Thus, a good clinical trial should provide clear and explicit = guidelines for defining and delineating the target volume, = for=20 dose=96volume constraints, and for the dose conformality in = target=20 volumes. Additional quality assurance for the dose = prescription,=20 recording, and reporting compliance should also be added and=20 routinely maintained for every clinical trial.

Even though IMRT optimization routines should provide a uniform=20 dose distribution, they also produce greater dose = inhomogeneity=20 through steep dose gradients in target volume (= 22,= 23)=20 compared with 3D-CRT. The greater dose inhomogeneity is due = to the=20 fact that ideal optimized IMRT plans cannot be executed with = the=20 use of existing multileaf collimator systems, which differ in = design, width, and other physical and mechanical = characteristics=20 (= 33).=20 These differences can result in IMRT plans that vary widely, = even=20 those with the best optimization algorithms. Some treatment = planning=20 systems may perform slightly better if they are used with a = better=20 multileaf collimator. However, regardless of the multileaf = collimator=20 design characteristics and the optimization of the algorithm, = the=20 prescribed dose will vary from the planned and delivered = doses due to=20 the inverse planning process.

Treatment with IMRT is a highly complex process in which the = dose=20 varies widely throughout the treatment volume when measured = through a=20 phantom plan to verify the actual treatment (= 34).=20 Our study also suggests that achieving a uniform dose to a = target=20 within =B110% is a tall order when treatment planning = variations=20 and dose recording are taken into account together with the = =B12%=20 in output calibration and the =B15% in IMRT patient dose = verification.=20 However, a strict dosimetry guideline for reduction in dose = variation=20 would greatly facilitate clinical outcome comparison for = patients who=20 are treated with IMRT.

It has been observed that the TCP is substantially reduced when=20 the target dose is nonuniform (= 18,= 19).=20 The radiation risk is nonlinear with respect to the radiation = dose,=20 and hence, treatment planning system algorithms that produce=20 differing degrees of nonuniformity in the target volume (F= igure=20 1) may lead to different clinical outcomes. Dosimetric=20 information is a proxy for the biologic effect that = correlates with=20 the clinical outcome. The variation in dose reporting in = IMRT, which=20 is reflective of the nonuniformity of the target dose, could = be=20 managed through a concept such as the equivalent uniform dose = (= 18).=20 Even though the equivalent uniform dose has been proposed as = a way to=20 overcome the confusion that can arise from the variability in = dose=20 per fraction treatment, it has not gained wide acceptability = in=20 clinical practice. Various models for TCP and NTCP (= 16,= 17)=20 have been proposed during the 3D-CRT era with respect to = dose,=20 dose per fraction, volume, and degree of normal tissue=20 complications. However, the proper parameters derived from = clinical=20 outcome are still a matter of debate. These models could be = useful=20 tools in IMRT for comparing clinical outcomes.

IMRT requires great precision in patient positioning through=20 immobilization and greater reproducibility of the isocenter = in=20 patients because of the high dose gradient. The geometric = center of=20 the target volume in 3D-CRT is matched precisely with the = machine=20 isocenter within =B12 mm. This concept is now fixed within = the=20 radiation oncology community through ICRU-50 Report. In IMRT, = however, the concept of an isocenter dose is not meaningful = because=20 the isocenter can be placed anywhere inside the patient as = long as it=20 is reproducible on a daily basis as shown in F= igure=20 4 for a prostate cancer patient and a head and neck = cancer=20 patient. Because the isocenter can be located in either the = target or=20 in normal tissue, the isocenter dose varies widely from the=20 prescribed dose (F= igure=20 1). Hence, the utility of reporting the isocenter dose in = IMRT is=20 limited and has no clinical relevance as it does in 3D-CRT. = The=20 isocenter dose or the reference dose, as suggested by = ICRU-50,=20 should not be used in IMRT because, in general, it does not=20 relate to the target dose.


<= IMG=20 height=3D127 alt=3D"Figure 4" hspace=3D10=20 = src=3D"http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/= jncidjn020f04_4c.gif"=20 width=3D200 vspace=3D5 border=3D2>
View = larger=20 version (82K):
[= in=20 this window]
[in a new window]
[Do= wnload=20 PowerPoint slide]
  		Figure 4. = Isodose plots=20 of the intensity-modulated radiation therapy (IMRT) dose=20 distribution in three planes (sagital, coronal, and axial) = for a=20 patient with head and neck cancer (upper panels) and = a=20 patient with prostate cancer (lower panels). Red = dots=20 indicate the location of the isocenter point. The isocenter = dose in=20 IMRT is irrelevant because this could be in the region of = low dose=20 or in an organ at risk and does not necessarily represent = dose to=20 the target volume as is required by the International = Commission on=20 Radiation Units and Measurements 50 for dose reporting in=20 three-dimensional conformal radiation therapy. Colored = lines=20 represent various isodose lines. =

 = ;
Dosimetric=20 variations between the prescribed and the recorded dose could = be=20 reduced by establishing international and/or national = guidelines on=20 dose prescription and reporting, volume definitions (eg, = intersection=20 and union of targets and organs at risk), margin status, and = volume=20 extension in buildup region and overlapping structures. = Although=20 various radiation societies have undertaken the role of = providing=20 educational activities for defining target volumes, it will = take time=20 and the effort of the practicing physicians and physicists to = achieve=20 this goal. At the present time, however, this retrospective = study=20 shows that IMRT produces relatively greater dose = inhomogeneity than=20 3D-CRT, even though it is theoretically supposed to provide a = uniform=20 dose. For clinical trials, the median dose could be used for = dose=20 reporting in IMRT given that it is very close to prescribed = dose (F= igure=20 1).

This study has several limitations, including the lack of = uniformity=20 in volume delineation among institutions, the unavailability = of=20 quality-assurance data for the treatment planning algorithms, = and the=20 uniformity of IMRT input constraints. This study is also = limited to=20 the five treatment planning systems from five institutions, = some of=20 which had limited IMRT planning data in certain disease = sites, such=20 as head and neck and brain. Given these limitations, it is = beyond the=20 scope of this study to provide a rank of merit for any = treatment=20 planning systems. Additional work is needed to quantify such=20 differences.


3D"    NOTES
Top
Abstract
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Context and Caveats
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Subjects and Methods
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Results
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Discussion
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>References
3D"Notes
 The authors received no external funding for = this=20 study.


3D"    REFERENCES
Top
Abstract
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Context and Caveats
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Subjects and Methods
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Results
<= IMG=20 height=3D9 alt=3D" " hspace=3D5=20 src=3D"http://jnci.oxfordjournals.org/icons/toc/uarrow.gif" = width=3D11=20 border=3D0>Discussion
3D"References
Notes
 

1. TG-21. A protocol for the=20 determination of absorbed dose from high-energy photon and electron = beams. Med=20 Phys. (1983) 10(6):741=96771.[CrossRef][ISI][Medline]

2. TG-51. AAPM's TG-51 = protocol for=20 clinical reference dosimetry of high-energy photon and electron beams. = Med Phys.=20 (1999) 26(9):1847=961870.[CrossRef][ISI][Medline]

3. Dische S, Saunders MI, = Williams C,=20 Hopkins A, Aird E. Precision in reporting the dose given in a course of=20 radiotherapy. Radiother Oncol. (1993) 29(3):287=96293.[CrossRef][ISI][Medline]

4. ICRU 29. Dose specification = for=20 reporting external beam therapy with photons and electron. (1978) = Bethesda, MD:=20 ICRU: International Commission on Radiation Units and Measurements. ICRU = Report=20 29.

5. ICRU 50. Prescribing, = recording, and=20 reporting photon beam therapy. (1993) Bethesda, MD: International = Commission on=20 Radiation Units and Measurements. ICRU Report 50.

6. ICRU 62. Prescribing, = recording, and=20 reporting photon beam therapy (supplement to ICRU Report 50). (1999) = Bethesda,=20 MD: International Commission on Radiation Units and Measurements. ICRU = Report=20 62.

7. TG-40. Comprehensive QA for = radiation=20 oncology: report of AAPM Radiation Therapy Committee Task Group 40. Med = Phys.=20 (1994) 21(4):581=96618.[CrossRef][ISI][Medline]

8. Mijnheer B. Current = clinical practice=20 versus new developments in target volume and dose specification = procedures: a=20 contradiction? Acta Oncol. (1997) 36(8):785=96788.[CrossRef][ISI][Medline]

9. Kukolowicz PF, Mijnheer BJ. = Comparison between dose values specified at the ICRU reference point and = mean=20 dose to the planning target volume. Radiother Oncol. (1997) = 42:271=96277.[CrossRef][ISI][Medline]

10. Levene MB, Kijewski PK, = Chin LM,=20 Bjarngard BE, Hellman S. Computer-controlled radiation therapy. = Radiology.=20 (1978) 129:769=96775.[Abstract]

11. Chin LM, Kijewski P, = Svensson GK,=20 Chaffey JT, Levene MB, Bjarngard BE. A computer-controlled radiation = therapy=20 machine for pelvic and para-aortic nodal areas. Int J Radiat Oncol Biol = Phys.=20 (1981) 7(1):61=9670.[ISI][Medline]

12. Chin LM, Kijewski PK, = Svensson GK,=20 Bjarngard BE. Dose optimization with computer-controlled gantry = rotation,=20 collimator motion and dose-rate variation. Int J Radiat Oncol Biol Phys. = (1983)=20 9(5):723=96729.[ISI][Medline]

13. Morrill SM, Lam KS, Lane = RG, Langer=20 M, Rosen II. Very fast simulated reannealing in radiation therapy = treatment plan=20 optimization. Int J Radiat Oncol Biol Phys. (1995) 31(1):179=96188.[ISI][Medline]

14. Webb S. = Intensity-modulated=20 radiation therapy (2000) Bristol, UK: Institute of Physics = Publishing.

15. IMRT Collaborative = Working Group.=20 Intensity-modulated radiotherapy: current status and issues of interest. = Int J=20 Radiat Oncol Biol Phys. (2001)=20 51(4):880=96914.[CrossRef][ISI][Medline]

16. Burman C, Kutcher GJ, = Emami B,=20 Goitein M. Fitting of normal tissue tolerance data to an analytical = function.=20 Int J Radiat Oncol Biol Phys. (1991) 21(1):123=96135.[ISI][Medline]

17. Kutcher GJ, Burman C, = Brewster L,=20 Goitein M, Mohan R. Histogram reduction method for calculating = complication=20 probabilities for three-dimensional treatment planning evaluations. Int = J Radiat=20 Oncol Biol Phys. (1991) 21(1):137=96146.[ISI][Medline]

18. Niemierko A. Reporting = and=20 analyzing dose distribution s: a concept of equivalent uniform dose. Med = Phys.=20 (1997) 24(1):103=96110.[CrossRef][ISI][Medline]

19. Goitein M, Niemierko A. = Intensity=20 modulated therapy and inhomogeneous dose to the tumor: a note of = caution. Int J=20 Radiat Oncol Biol Phys. (1996)=20 36(2):519=96522.[ISI][Medline]

20. Das IJ, Bieda M, Cheng C, = et al.=20 Dosimetric comparison of inverse treatment planning system for IMRT: a=20 collaborative study. Med Phys. (2004) 31(6):1750.

21. Cheng CW, Das IJ. = Treatment plan=20 evaluation using dose-volume histogram (DVH) and spatial dose-volume = histogram=20 (zDVH). Int J Radiat Oncol Biol Phys. (1999) 43(5):1143=961150.[CrossRef][ISI][Medline]

22. Boyer AL, Geis P, Grant = W, Carol M.=20 Modulated beam conformal therapy for head and neck tumors. Int J Radiat = Oncol=20 Biol Phys. (1997) 39(1):227=96236.[ISI][Medline]

23. Zhou J, Fei D, Wu Q. = Potential of=20 intensity-modulated radiotherapy to escalate doses to head-and-neck = cancers:=20 what is the maximal dose? Int J Radiat Oncol Biol Phys. (2003) = 57(3):673=96682.[ISI][Medline]

24. Vineberg KA, Eisbruch A, = Coselmon=20 MM, McShan DL, Kessler ML, Fraass BA. Is uniform target dose possible in = IMRT=20 plans in the head and neck? Int J Radiat Oncol Biol Phys. (2002)=20 52(5):1159=961172.[CrossRef][ISI][Medline]

25. Glatstein E. The return = of the=20 snake oil salesmen. Int J Radiat Oncol Biol Phys. (2003) = 55(3):561=96562.[ISI][Medline]

26. Cazzaniga L, Marinoni M, = Bossi A,=20 et al. Interphysician variability in defining the planning target volume = in the=20 irradiation of prostate and seminal vesicles. Radiother Oncol. (1998)=20 28:293=96296.

27. Leunens G, Menten J, = Weltens C,=20 Verstraete J, van der Schueren E. Quality assessment of medical decision = making=20 in radiation oncology: variability in target volume delineation for = brain=20 tumors. Radiother Oncol. (1993) 28:169=96175.

28. Ketting C, Seymour M, = Kalet I,=20 Unger J, Hummel S, Jacky J. Consistency of three-dimensional planning = target=20 volumes across physicians and institutions. Int J Radiat Oncol Biol = Phys. (1997)=20 37(2):445=96453.[CrossRef][ISI][Medline]

29. Van de Steene J, Linthout = N, Mey J,=20 et al. Definition of gross tumor volume in lung cancer: inter-observer=20 variability. Radiother Oncol. (2002) 62(1):37=9649.[CrossRef][ISI][Medline]

30. Hurkmans CW, Borger JH, = Pieters BR,=20 Russell NS, Jansen EP, Mijnheer BJ. Variability in target volume = delineation on=20 CT scans of the breast. Int J Radiat Oncol Biol Phys. (2001) = 50(5):1366=961372.[ISI][Medline]

31. Caldwell CB, Mah K, Ung = YC, et al.=20 Observer variation in contouring gross tumor volume in patients with = poorly=20 defined non-small-cell lung tumors on CT: the impact of 18FDG-hybrid PET = fusion.=20 Int J Radiat Oncol Biol Phys. (2001) 51(4):923=96931.[CrossRef][ISI][Medline]

32. Fiorino C, Reni M, = Bolognesi A,=20 Cattaneo GM, Calandrino R. Intra- and inter-observer variability in = contouring=20 prostate and seminal vesicles: implications for conformal treatment = planning.=20 Radiother Oncol. (1998) 47(3):285=96292.[CrossRef][ISI][Medline]

33. Huq MS, Das IJ, Steinberg = T, Galvin=20 JM. A dosimetric comparison of various multileaf collimators. Phys Med = Biol.=20 (2002) 47(12):N159=96N170.[CrossRef][ISI][Medline]

34. Dong L, Antolak J, = Salehpour M, et=20 al. Patient-specific point dose measurement for IMRT monitor unit = verification.=20 Int J Radiat Oncol Biol Phys. (2003) 56(3):867=96877.[ISI][Medline]

Manuscript received August 29, 2007; revised December 20, 2007; = accepted=20 January 14, 2008.

3D"
CiteULike    Connotea    Del.icio.us    What's = this?=20

Editorial about this Article

Clinically Relevant Standards for Intensity-Modulated = Radiation=20 Therapy Dose Prescription=20
John Willins and Lisa Kachnic
J Natl Cancer Inst 2008 100: = 288-290.=20 [Ex= tract]=20 [Full = Text]

Related Article in JNCI

IN THIS ISSUE
J Natl Cancer Inst 2008 100: = 287.=20 [Ex= tract]=20 [Full = Text]



This article has been cited by other=20 articles:=20

3D""=20
 3D""=20 3D"Home
 3D""=20 3D"JNCI3D"Home
J. Willins and L. Kachnic
Clinically Relevant = Standards=20 for Intensity-Modulated Radiation Therapy Dose = Prescription
J=20 Natl Cancer Inst, March 5, 2008; 100(5): 288 - 290. =
[Full = Text] [PDF]=20
3D""=20=20 		3D""=20

This = Article
3D"
3D"Right Ab= stract=20 3D"Freely
3D"Right FRE= E=20 Full Text (PDF) 3D"Freely
3D"Right Suppl= ementary=20 Figure
3D"Right OA All = Versions=20 of this Article:
100/5/300    most recent
djn020= v1=20
3D"Right Alert = me when this article is cited
3D"Right Aler= t=20 me if a correction is posted
3D"
Services
3D"
3D"Right Email=20 this article to a friend
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in ISI Web of Science
3D"Right Similar=20 articles in PubMed
3D"Right Alert me to=20 new issues of the journal
3D"Right Add=20 to My Personal Archive
3D"Right D= ownload=20 to citation manager
3D"Right Request=20 Permissions
3D"
Google = Scholar
3D"
3D"Right Articles by Das, I. J. =
3D"Right Articles by Glatstein, E. =
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Das, I. J. =
3D"Right Articles by Glatstein, E. =
3D"
Related = Collections
3D"
3D"Right Editorial=20 about this Article
3D"Right Related=20 Article in JNCI
3D"
Social = Bookmarking
3D"
3D"         
What's = this? =

------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/toc/toc_arrowprev.gif R0lGODlhCQAIAKIAAP////8zAP9OIv+tmf+7qgAAAAAAAAAAACH5BAAAAAAALAAAAAAJAAgAAAMU CLowwk2EsNycgMiLI6fVBjIWVCUAOw== ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/toc/toc_arrownext.gif R0lGODlhCQAIAKIAAP////8zAP/k3f9pRP+FZv+giP/x7gAAACH5BAAAAAAALAAAAAAJAAgAAAMX OCTQPiEsB2CUrN5LjOXMNzXQ6BQZBSQAOw== ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAQAICRAEAOw== ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/shared/misc/arrowTtrim.gif R0lGODlhBAAJAIABAGZmZv///yH5BAEAAAEALAAAAAAEAAkAAAIKjAMHidsLm2HHFAA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/shared/toc/free.gif R0lGODlhIAAHAIABANYTNP///yH5BAEAAAEALAAAAAAgAAcAQAIjjI+pqwDpTAzzVPjQ3Nl2Boah Q0pkd2YpVq1mW2IypZ5vVQAAOw== ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/shared/socbookmark/citeulike.gif R0lGODlhEAAQAJEAACeBzf///////wAAACH5BAEAAAIALAAAAAAQABAAQAIlRI6ZYOzvApOw0qvO 3BXemX1N94gkR50jlqGq+4qh/K41OyNAAQA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/shared/socbookmark/connotea.gif R0lGODlhEAAQAPcAAJSltZytvZy1vaW1xq29xrXGzr3GzsYYMcYhOcbO1s7W3tZKWtZSY9Zjc9be 59bn795zhN7n5+eMnOecpefv7++lre+tte+9ve/39/fO1vfe3vf39/f////n5//v7/////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////////////////////////////////////////ywAAAAAEAAQAAAIpAA/CBxo AACACAMTCsSA4QMAAQYRKhQYIYABAhwiGJwokILBhgIfcNgAUiAHCig1aPAgMAGABBw+cCAAIOaH AwwOHPBQIMDBDzQLDDxgAQKCDhE4GPQ4wObNCx46DHRg0KACmU8rNJD6waUAjy8f3Jyw4IAGgR8F FviZAYIEmwNKUjCQYINTBwYcOE3ocSBTjhQPFhxgYK/CqgI4GFaokcCGiQEBADs= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/shared/socbookmark/delicious.gif R0lGODlhEAASAPcAAAAAAP///93d3QAA/wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAAEAASAAAIRwADCBxI sKDBgwgJDljIcCHChg0fQnR4cCJFgxYHSJy4EWLHhgBCigwpoKTJkiNHnjyZUuRKky1JvhQQE8BM mjFv1tSZc2ZAADs= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/toc/rarrow.gif R0lGODlhCgAVALMAAC4ugh8feQoKbC4vguvs8ykpfvz9/Skpf+7u9QUFaR0ddwAAZv///wAAAAAA AAAAACH5BAAAAAAALAAAAAAKABUAQAQ9kMlJ1borHSRt3pXGUYyHZQUBjCSztt0lVqecmihhGMoM /wFQy+KbmIq4Dyd5EQySiRQPE9XtiMJJkEWJAAA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/toc/uarrow.gif R0lGODlhCwAJAKIAAN/f7L6+2IaGtgkJawAAZv///wAAAAAAACH5BAAAAAAALAAAAAALAAkAQAMW WLrczmEQIl4BLs5NrY1Vo23hyE1CAgA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/toc/dot.gif R0lGODlhCwAJAIAAAP///0JCSiH5BAAAAAAALAAAAAALAAkAQAIMhI+pGb2PWoC0yooKADs= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/toc/darrow.gif R0lGODlhCwAJAKIAAN/f7L6+2IaGtgkJawAAZv///wAAAAAAACH5BAAAAAAALAAAAAALAAkAQAMW WLrcBS4MQqtwWEl6c9tV2IFcNHRKAgA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/jncidjn020f01_4c.gif R0lGODdhyABzAOcAAAAAGM3uve7u9ubm7jE5e/+Dg1pi5v///2JiYsXmrHuU9r3m1YP/Oc2LrIPV i/9ze6z/c83V1bT/c9Xuxf//5pS9tLT/e829zbT/gzFK1f/e5sXN9v9zc5RilP97g729zRAQMf97 e8X/vVqD5qTetM3m3ouLi4tKarS9/zla5rTN9qSs1bTug5SUi/+cpP+LlLRznJSUlFJilP+cnP9B St6knP+Li1pSUoP/KXvNiyApSr3e5qT/Ylpze6y9/2KslIOUg9Xe/5z/Yub/vVJi7kqDg6z/atX/ vSApi0FSg9Xm1fb/9ouUrP+stNXe5v+9vcX/g2J75pSk1ay95uZ7i7T/i/9iav+0vXt7xcX/rMX/ nP+srO7/5r3N1f/V1b3/i//N1f97i5zNxf+krP+UnP/e3jlKanP/GFoxUs3V//+UlJz/Uv+0tEFK xf/Fvf+kpO7/zaz/e9Xm9tVKWv/u7oN7e73upGpiezkxQdVie/bu9v/29v/NxZSclJx7i7SLvb3/ g4O0xWqDi6SkpP9zg6SknP/m5ubN1d7/xYPmas3/nP+UpO7m7sX/lO7mxc3/pLS9vcX/tLS9tP+9 xc3/rP/V3v+svSAYQYv/QTlic6Sk7lpz3sXV9qy0tFpSrObV3v+LnKysrPb/3ua9vdXV1dX/tLS0 tN7V1dXN5r3/e3uLxWJi3tXNrO7/3ub/zZycnN7/7sXFxcXFvf+ktMX/pPb/7s3Nzc3Nxe729pSs 9u725t6sxd7/vaTmlP+Di//N3ubu7ub/1d7/tL29vebu3tXe3jE5rObu/6y07v//7vb29tX/rKy9 pM3N5r3Fvb3FtL2sxeb/xaT/alqL5t7e3tXe1f9SYsXF3u7u7u7u5ubm5ubm3vb/5vb2//b25t7e /+6UnKykzf/u9ubm9tX/pL3u1d7/zdXV7u7/9kpa3v+0xe7u/6S07v/e7ouU5rT/nL29/+72/83u 3u7/1f9qc+b25qzF/83/1f/m7v+crNXu7v/Fzf//9vb////2/3ukxSwAAAAAyABzAEAI/wAPCBwo kJTAYdgIKlzIsKHDhxAjSpxIsaLFixgHYqPGMaHAQQewxaB2IJSzjChTCtSm8iHLlgyx6YJ54GXG YgeohQpFECEpUspy2mLojwydiuIkahizj4y/Mi7cFOT3cM/KlHTAOLRJU2PQA3te4BO4x2pFrheL keozKNZDakMJanCj7gqnfhoGlhWI70WTSQcmaaDjwssYFy8QV3IjjoxUfwKu4PHwp044M2hMkZlz QgO4A/4mGQJz5U2ZJlTUTJrhYVIlgviSChx9gJ+hK3v8NfE32xBBtDAZgarxVSCnbk2OgtHKe2A+ NgyBV8RpaxBPh4PwmJHR5sMGd5s6mP/qNgreLilM8PTZcCcClhqW3OSrA8IMgTYp0t33RAAJkh7I dIPFHXWkQwE1CJhhQh0A1IHLMDcgYEIyFCCgAx6XXGJMG0ikYwYAAKyyySYKEJGOAXco0EY6RHjC YhsGELFJG1FgQcQqv4Ayyi5lUOFHPm9wQMUnlfiiwTgN7FJJJXs8Qc8bbrRGxxjWlLHHBWbccUMb WHDiDjRBxMMHOFgkQYAnqxCgChZrXpKEFPHgssE5o1ygShJ3qHOBNXOo4QEZL8CAxiV1UJWPbwPh pE0ophDkkUfbyPKIK4h8EUxxAqFjzgHl2BHMAUuUIIIP8TSihUBc1OIQJSWgEAAlmyr/tM44Ah1D iRhSrIPAMFyYE8wXATxCiSulEMSPBZQcgYMFoJLDBT+98nLEQEu0gogw5PDzyBmUQPCFEEJIQ8sX cVBCCQMQoIOOCFl8wYtC/aAzUC1ffGHHBDysQYlAX0z70BET2PPOFzxgEgcm0iACASY8aMHLt2u0 8uu+DDlxACmvgHTQMLFgUwdLsuQgTDK1mQEEHNFoocI4lFhQSykTiHEPQYgg0opCVBGk6kIopBHN F66gw4sEDuRSjj2tQHCEPxsEMRBL9GoxD0HmGEHLPFpoYSkEEFD1yKe8BBMMIgcEww0/wQTwbkS1 HJHzQ5Q8Ugs22OT8iAoltNIKL5Qg/6KIOfy0ssTbCw2gUClr10b4QjhRM8gwA1EzzC3YxGVLLFy4 gqrm3CwxEDthIlOPvGbX44MCG9xDtrGt8KNqKwG8A8cBrizjyjcBtNJP0+wstPgBdmgeUTDLLN6K 1tIA8mltqUqnUNu/OwQtNt4oJEUQpey8UC33sODvQMQ4NI/2DeFEiinXNaRNXAOVgoFANhN0zAHX xCPQERTDS/zywVASfUO1QMTilvEprrgifyhp2xKc1xJsYMocXHhIKxBIkPChRFGMeogpTiK9R0Qw I614hEPG0TuLMLAlJ0yJA2lik4QURxmYYghO0Ae5gXzlK9pwS1dasgQPKiQY/XiaQP9q8T+UpBAl 2MAFC1OCE2y8ooYHsMUwhmKKoZCCfTuUSOswoo0gdqUV/jpiRpJokf+JsSH9wMlCpDgMZVyHYxWp HEkwEsAiNuQYG0DH8gwXOWfMMSQrsUUMI8IVZVBjhQuBIUUQWQxbOPIAzjhFBA6gjGFogxrKIEUE goIIbvxmIFdkCTaAEhE1ZvGUAuEHP5KhSlRipJWujKUsZ0nLg8QgBrEYRlvONwxG8aSXsQgmDV+B S1P0cpC1TCZE4KLMJbryjBdBZEv4eJOaxMAgDoFjRPagFZp0g1ZPMAQ/JkGPfRwAH2OACDQvss44 Vg8m7VRIE1+BxZfEIijrEwgWsEn/Eyv1AwWguMJA9jGG16RyIWA4CljwIdDIXYEM6aSIP3xTCa08 IS8KiedEyMiQPTTBSgQhTUOoiRHzaQOKB9DYdZwxBxp4gBBWsIIHfLEFX1iBT9YIgwesQA8P7NQK +/CFL3r6CxdYAQaLsMQs9qGOMPyFHlZowgMI8YB8/OIEaHCDH9BgBSrYgAMvgOovmvALMLABFL6g QhPC4AUX0PQF+wADT5+QmDHQwxo0sEZUQWGNSfiCDPRYxAsesBww1GAf+SDDJJqwnDyg4Qlg8AIY bFBQF7yhsJjFrBVAkQ965MENi7ABPehBCHpA1BrWsMEDaDCDGtSgAXmwhgvA4AJr/8ygCVbI607J IFnJgqEJvpgFGTJb2AiY4hUmQKkpRhkLkuhEUzvQkBQGcYl/AKETyHgGE7CghBsIwgEm0EES6vCP H2SCVl04gBc54YNM2WMD7JCDPSoghiEsoR/9oFU/otEHZLjDB30oBB52kIZpvMMJDnAAOjYQCEBg 4gw4OIMQCKKuIAYRHbDALzruocdSiOESSHCHIHrRi3/8gx3H4IQCFKACBXACHblghwpyIYUFJCIR YhBDIByQgzOcgQTVeAYCdIGLfvCjHyoAAhOKkIkeKGEb9VCCKPhRDfVuYANSmOQBkuENSVCgFkrQ hjFyMYJNjOAS00jED3zMZnnh1/9isXiisRSyjVjw4wsiFAc/pPG1I9zBFsejhLwOAMG22aMbB5jC /IIBLYY8ohHAWAEs5qE5TiygHt0wRy8YgOda9G1vClECBZKxjMQRhBtH4IYrgrEEV6CNC4h4BAQQ wQseUIUXrgDcSzKXs1rsrBWlMMcjbjYRREgjDsGoRTQoUax+TKEbX1iWt6KBan7wAgN6AzbftPEy c7gCA19QBC/MYTuIFCMUMahDoxxiTIGUYnW0oNgRllG2WizhHlM4ggApEUFVcyEaA5lHrGgRjVoM myH8QEQjslCBePQDGbCIBi+anYVBo2UZWvBk2Zbn7uURESJK8NwpBaCHhQSD2K7/W8gyVvfJC4Yk BrcgyFeak8+B8AACtSFfzYJxhCOgo2cN4QIviF2KqRGLIK0ox/y6UUKBcIPlt6pXzmziCpFHpBT9 CjpVNMo26llEFJQgn0As6BCeO8R8bRxILjtWBwFEUYcKOQIPtOeDc0ikfwNxhakVggunIboETiPI BtJwgA2Mw4sHGMARAKFxiyxB7C0/JUdfZkd12lAgzZGIokzAPlJwjBqvIMnlJEiyiMCi2V1Jg/0I 4jmWlEJ4O+wiKqVJEMSZEHxpoUYsTMHP6GCxmRQ5Avlkv8NWeJL4WaR9SrguEOqEovcL6QTcZfnx jIwD0Vd5pisFgMyHVD+jTJxI/w6BX5Fj9C4eKMA+SbPIfIhw35kN6X6iJiJ/XSAamUGp3iBhmJCS Z1SRg8QIdENJC+ER96cQytANCUiADKFE+OdCBUiAg5QQEAgvQWEV+4cNB8gQQfGADEgQByh/AxEK ylA5BmEKnYANwAAM2rCCLciCMAiDLziDLliDMdiCNEiDN1iDOViDEaCDQLiDPbiDwPCDNhiEQSiE KwgMpEANRIiDRxiFOBgBMiiFPMiDWkZI00d+XBRL7fcQymdE4acNMZA+H7gSW3gA66AJtKQOo8AK FHAAY6BQD+EC+PCFLnFKRxGGGdF+jfMK03cdocASuscXdkQHdDgQkyAV2+QF+f9gFgRhCE1QGwSx By4AiWCRfaiEhw3BhxBxGgaFexdEDcb0ewqhTQQxJVAxFg9xGgclEYYAGHI4CYSQBzDQUAKhitEB EVeQiAOReVtxSvswCbqAKW/Ais0BjHnoch6DUiBROQmxQQ2xB7hoCzpADfyADy4wEOOADAdAB7rh BqCwB75RBnyhUOZ4DMfQAPlAB3vQjtOYiQMxCmNQjwdgCC5AUHqhEHElEIxBV+pzSmmwAbhQHNQo EFDxjbI4EE1gThqAietnETgRTH/EENTQBXRABpWwD01wBV5gBtRQCfiwDwJ1BdlYCTM1CXRgTgfg BtbwB7tgCQXwAmwwCT5FBnv/cBqO4AcywA6qQACQYAk3cAfkyA+/gAZ1UFaEwBQeIFtewIigMQa+ 0ATi2IsH4AJ/4hTyeAB/EQb58AdUMAu5SAecqBAIAAn9wAghNRb7gFF08JC4ZQ1g4FHmOBAuMApV IRvlY03Thw3+sAQeQQ130AFoEAJNsAVXIAcboAmn0A790A6zYAhsQAi+gAejgA9kAA1ooAZlMA5t IAX2oAnjQABU8A3jkAYr4AcdUAObkA4rUBus0AKOQAG0uQVeQAFL0A01AAIngAeh4AiDeQgHAA1+ gAcw8AlsEAIe4AaG8AIr6QH4OAvf4AUd0AAUEFlgsAXg8AJqoAFgUAaj4AuV/0ANJ0APoLAIasAB HkADVvAAdNAE1sAB9CBOYPA7GgADJ+AJ4EAFevUAtnAIHuAClcAGkwgWjlAGFCAK7oAF1WkN9BAC 9PAAeeACM2AFvpCRV1CgVtFNMnQAwyBnA9EoJ3UKiUcAGaAAGyIDBoAFUXAH3IEESdAgoSAFJoAF AKADw5Ahl7AdKFANtrACmlAjChAFKBAEZmAMZjAKXNADOnADN1AHEYANpsAEmZAE2yEDK4AZaHAD EXANPtAAHaAAMiAFKGALn7kC8KAJBnAiRCAF36AJm7ACG9AGqnANmrCY7sAODIoFWCAiq+AJnhAF RBAFIlIjSJACGeAJRDCk6f+wCoTqCR2wCm3gCWiwCsbgCRlgDFiQqW2gA3dAACBwqGuKBG2wIkTg DkFgApfQBiCQDhqSAf7RqunQBquABgAAAmiAVblKqWjgCVZXDMpgC6GQhgTxDD8gDFMTRJh0ALng DgRhC4WwDjvwDglAY4LADzPBG9i3EElgC3rQAywgCsRGEBUAeLkgD43XCYVADROACYlQAgOBCJQg cqqyBEdQClrwCDtwDQdwBI/QeELnCvkqBniAB88QLAsRLweAYQJhdwLxDpggBGfAABTLAAPDANIQ D/wgADOhXs16APFgdQIxDqqAaDcACQfQAzEwEMlgODpXCq1EAcJAAVQhsgf/YDGOkz4cY0mAWBIV AAVfYAHLcK/S0nMkQAK9oAUB0AtVYAQQ0AtqQwnS0DDkwAON0HOI0HPmgLWRgAm98A5GMLTCEABi gAF9I699g3VZcATSwgskxgI/kAO9QA7CcK91KwyPgAGI8wW0wAtAOy5YxwOIw7a8sAy0ULe8kAC0 AAE4wAPRBmFxwACYAAgOFrFrcAZrcK9Ei3XJIgzL0AhfAAHjggFrwAKKwAN8JgRrUAqPcHMHI7hH kAg8AAhrsAZfAAgswAM4gAkYIAGAQAlawANCgAkW0AhDO7hYewRVFgu49BCkIAZxGAyaU3QCwXRe 1A9XIw/vcADIsAOJMGVH/8C33EAvEFAsqJJKEABwAjFBVBEPveBmBLEOKHAN5VAOB9AKLPA2+uZ0 YUcQRwB71JJ3/lMbR1AC8/BBAnHAz5M9d6cqlEALB/AIWkBsBmcppfDAxssCUDA1B6AFEEAJGjcB EzwvjeBJtbAMNitPtlCG06cNJTgAVLENcEgVxkeJB8ALa0ALVAEt8kAJQdALQiA3y1AKF8wLtLA6 lMALiAB5/BA3PIABdoAO3KA3nOA0YwPAQjRxA8ELe3e/lFYKcSAKz1IbIExowhMMWrANLWEP38B6 B0AMdpA481A8DOFrB3cA3ACzB9A2auwQXJDCBIETzjCsXnRS2qAHz1cTOv/EBbRQdXvMDVkgD7Xx NQuRm1LwmiPbXk0svUsgcJ5TC3FgvupYC3qjEP+2AeWQCoigB93AD66gxvMgQr6TahZRC6ymBK6A xS0xN0qUSu/wD/AwEPwwaHkHeWnjOwIEyPKUEyaACkVkCxykENzQeIETDb0wPxDRCjvjOaXAcQwR DHYQeLW3DOU7rjWBERLMDXdcxnusicUXhkFkDo0nESnkyHu5E1BkCmtXCJDTFvNCxwqxAdeAAusw QuJMiZXnEK0QKwKRa0L0isBGEfi6OLCmBK7Eh6aJePTMRJlkCydECsQKguywrQxxDYdHaAKkSmbD BQGAADEEawLRC/YrEfz/wALKLBGPF4yzN0gosHoL0Q13QHa/YQ7FEgrE1Euv0AmhMAhMvROD8Arp 0zgmsG6UdEjFMEc1d2rzhgFrQ3iFxwkjaw8NUcq0w3INgWgLcGgroNEN6wNuc87at9NbjAHCkBHA 4AXQcVwxoEvoEwtG/dRLnTFukUY1Mawa0TEXkxBZXcdFmhGlYM4TMSxBt0Be6ErFaBHexhC68Ap3 4KExkDE7sdTDEANPPUjzFNIFEdJc8Ai9tgyQRzO8QAp2QDaeVnk+UNBnUdmodNnr+wildxHAEAQo cACvcFyQsNfo89SvUNwjEcgeij5xoc+NMkUlgdqzFA3me3sLe9Nl5M47/yQA7zRN4UcNP/EQozdL YrMQv63dm3jRIrg9kP3Q1QTS/JRJl7RcNWGKXPgQyRZ5p1SWBfjeFBGR0xFnvResQYFNi30RNSMR 31cR1xBE7IDbCcDa7Y1KBVnL0UPgFGFK5mbdCxEKjpMxgPhEgI0+r1ARjd0QaXDQcC0QcQbVo83U gyCsnGcKn60xyygQoLcNy73c1lEHl1OGHuF++vcK2LAoTE0NuJRDuPRE5w1+AgEJxhQKwmodpjAI e52wHj4QkLB2u1cSJgAJVN5LplDm6FPmkMAoVC4JSn3mVd4JxnTmbD4MVB4KZA4JZg4JYsAMbp4D zxDnVP4B6GMKhA4JUP9N5WTO5nCO541uCnO+5npuTJ3QCXY+DKbQB6bADBXADGk+54yO6Y6O6XKu 53d+6ZDA1Ipe6HYO6Y5+53KO6WsuCXA+CJ2w6nhe5kqt5qEeCp0gEblkhgQBeoMACaZoCpKACj0g CyhVEtjw1MKqEE4UC+om7MqQS8VNggSx2dax12hR42xB3eCTMbZwB7eAUsoQA9UBiFQtEEZtC3Ww 5gpx5h/aSwpB2ksdA6bAFYIN1bynENVB7VFeEKTw1M7Q7spQB4VA7X693w7/8BAf8RJvEeWtz47k eXBxRRdjC553RRx/RcBgCuQ98bX0jCag2NqAC7iQRCuv8knE8i/v8jL/3/I0D/M1f/M4H/Mtb/N0 M/M2v/Myz/M+7/I/X/Q5P/RCb/RGf/Mwv/Q6//S4wLFbYUgvseAkr9MXLnkCPhFCnRYTIY1XT0i6 LXm9jELhdz5YpEO2oNj6HfZSnvXJ539m73JShEWhsBEifgARQKwk7Up04A3xXRUv/t/uDX8XQdja 0LMOMfCYBw566Ur88ARuQAF7wBSz4RBWAeALofkC0QSVIABlrxIcPhFop98eUXOzwIoMgQ/QsRC5 cRFpwK9k4Z2P/40BGddab/hpscJQTRDXUUUpFc0QMQksqRDK2BCV0ASIQhDiYI7UYAZ78DbAqAFv 4N2xd9FuVxGVD1IE/zH6EUHYgx8dxHoF9ICLEfFbE+EFvqAVY2AFluACjDUQv4WJ/s0Qc+kQDIX1 yVf2TVCgi8jeAHFA4ECCBQkWw2Zq2CCDBG3FEmhPT0OKA/0ZqigwTRmMFBnd+Ddu4CQ6eyhSA2My o0E3L66s1LZSZsM9dARMtEiwjLgtlQbu6Wgw5kyKxQ7EUkiQobJhpA48PMCvzraMdRgeoENw3UA6 +FK68EXGn0FDbsDQASNQpUFxbwz50jCwxpUX+wiuNVgm7oF9fFyU8ZK14FCiRLt1w6aM4hh8DQ0F JUiscEOjpkxFIEhKGbVh2A5os0VRHBh+Ar1RK632Ch1/3Q5c2XJln/8HMGDYiDvghQwhL+LGHLgG 7486S4dWbN1Tw8SBMgcMkSkDppJJfwMEvvA5JqXASW4GjoH8kyLhyTLbHVKsNi0/Mi/3eB+Iz8ak A032CiRf/kAxaqQGDcvIFGcO8AcMNzQAIx9NvgnnlzE02MOFWcJioyY66PPiikmg8cUSeq7QoIxK rADFEHxcaMCMKaDxQ4Y/GviDjTJsqESNP1Z5gjmgHshnDzbmcMENfF4YI0c2smqijJrAGGOLPfLx xQNx3itpHEt+Gyg//RpCARVx0hPoj0oqIamM5hjTcY89msByIGAysq2ifozyD6KBQnsKvwvY8OBA vl5ogI8DyfDpgEn/0gLjBYE0MEQcR/exhMAmyHDBBjCuAA+3N5pQ55we0jnkFB06sGELMBowhJAH 3CCDDEOueEOcUfrBzQsTfXGBjAd88WcP3Mpw4wov9plknzc0IGOfWfbRw6d99qmHICwnAceLLcWp 4ZBPwBOojEmAquQKMFp9AVdw+ACHEcHGoK+JPNgAQ420DALKWsoOwGaQUAgKJbFBxnJmji0I2WIf NmA9RJN96NnFGmvA0c6KAjywpoBwwgmDHg12qQSaXfDRRJ0GNLlgFysmecEYNGAwEZpL/CijADY6 gKGMXTzxo4Mw/EADjRNs+OTVB9GYY76wJqHnAXqsWBo6Dfx4l49F/6whQ4MwXtCADkPAmaQJpq9g dQsbvHhinyt0fcGDS0Z57DFG2waDYXBooIEea2hgDIwCfNki7RfomeMSPp44hJ5ZrnjAYSs8qMFu Dnh0obbH8DGkq7YvL8MpzqjJiBop/ojljzxggCEdAnQYBJ0g+jnmAGrYcEMOSUwg428wlNnEABlA SCedTRRARoobsGBHkD2gIcCM5Rh5pYU6lJGFgmQ+o8aQV/5w5BUTwlllEyk2IYCADoC45g9xugEm nGvAaQCLPhRYpQZN/Dgnlw1MuKADLBpQhx4yDmkCGGrwMytYgwMeoIcHYGANpllBDeBwwx6uoBIX tIkTWGgDK7yxBf81uKEOfiiABogRi1iQogENqMUtQiEFJKjCBLJ4whM4yIY37OIQhtgCKFJikko0 wRAe0JJA6BQKp1TkHDowxiY2IQMZbMIYZtjABmBwAjRsog7scIcgRjAMLKwAAT3AQjpW8Y8fyACJ OjidDqKgiSh4ggB3OEA88EAKbPCjEHWQBB6IgAcQgEAHl5ABHfxwgyQkwRiewAMSDGCGG5iBAETI gO/SQQQD5I4IKdDBJDOwiQyk4JIpSMEq6AGDVeivAz74BiqusYJ4xOMb37hDB+y3jmNUYg55aMMc rLG0BtgtD8ZIAhYMQARipkABaWhGEswQBWZGgQhRWAUo3aGKdDT/EZRESEcGPkkELODhbrecAxo6 ILYCWMMXrhFIBEhhgvzsaxhIOUAoMmEPfdhjGvdUgRhkQIBMFCETZvCnDPrZz39kAg+Z6IEYxDAN eaADHfcYgQLEEIhcbKIHP1CEGH7wAyCUAwgK/UcXcvADMexAH4GogCCAcA95wAIdYnAALHKRAxG8 IwcM4IE5YLGDQMhDHgtw6A5aClSHuhQWIpjGCO4Z0X9sYhq5CIQ9IhqIaWwiECMYwT/+cU8FKOAf St3qUqdhD63KAwj/CEAm+FkEVZgBoD0wQz9HsAAVjCCg5QhEQc3Qg2l4NRMK2AQoN5GJFBThB4nI wUhhYVQnDOMV/7HgXEW28QNzlKIV12hdP7YRhA304xoCccYg7ig9ZCCgBa0IxBRy4Q9kbMUgIllB JsSghEfUoxS1GMgCyqGMFYhABUEQyA2qYYZnQKAHtoiHQMjBgy9wgxc8OIJA+gGLLERCBAdAh0uj ewBYWIASlOABBAohiTqs1KXrQMExUBCPDZwDnd3YgEjiIYQz1JcBZ0iEA+5b33oAIzEDOcYGSpAD EgyAHwcujUoGgL42aIIg2SBIH3RxDCdsow9wSEUOnhGNewjhHf0YiBNsEYNQXIUisngGFBBxgEfU AgGmOMA3XCuQJbjCDgtQaD2usYMspCYjYxGAO+JQhYakwR4HYP8EMtCxBJEM4hV6YMcRepEALmDX FQXRAgRKUYpglEYfSygFBngQDIK0ohHLIEcnbqGLAHzBHAeIAwM+fIQzSCMYtKBEPHzQjXe84x7B yC46DiAEIYD4AP3QghYmYIdHIOILTliHoQvSjc8eAJ2a2AE3XKEFRCiBHF9odDBqUYsvaAG3/ODF IxrSDyccgBSmKOJTYE2KUECkGM9ohCIg8IhWGATH/JiCD/jBBdy6YgkHoAUgDrAETlNkCRZQhBzs sYwVS5cgwXgzOo7hmngowxWNKGkFxEACURikyqSORkMo8QWD8GPFpWDBAbSwBlpAANRxWMIX6iuN ZWjhDDiwc0H/avGIeQiEC19oRAC8wQMecEEXByj1AYLR6wMQG7tV1gIguKGLLK8BE5jgAQYkAAEe CAEQpeDBGkrRCEQc2yBzcp0JACQQZaBiG9iI7DZuIQoeUGIgXEjNN+LxBVocIBmU4IY5SFCPIxw4 GJzoBzcewQ2KyMMB0fWxHDhBCVEsoRZgJnYjSuGKNx8gDesQBjlEMQRRUL3Mlj0CBHyuBWlwg8zL bgUX7C5xCFRbG7VwxRcgEIx1l1oL0eBCI9bAg3ksgRLVzgg31iCEUjyCB8JIRi2CkYZglMIcGYcA JiyQbi6IAQMQkMYXND+OYGjhERb4QikO/gVeNMIVlKjyvajx/woYV8QUdnIFL8bgiGUEQ9OhEMA8 HqGCXixhA71oRT+W0AV0cIMH1D7wI1rckEiUABGUuC0ihGGPa/jADkIQ9QFaQfV+zJgfExDIgTOy 6YLXghLzqLzq3c2NKjueG1o6gnTbkoFwBRboMi2gBC24sueiBGlYgy8ABCE4AkQohYHghWVohWNb AlrghWCIhlpABF7QAoFABFrwMd0bhN47AGXQDGWohonYBjGAg9SwhR6YntwjugOIBi2wg/TTg3FQ AV6ILlfoNUSQO4rjh0fIvdw7gHWIB1HALYmrMhKAPn4ANwU4hgmQA4GQDPWrhV2LPxHkP0TgB0ro vO2qhRM8AP9uKL4D6LRSEMCKOLpSUMN2s6wDqIcsGIthQ7UVW4JWOAIM+IIr4wNHKLtRmx4udDka 0wImXIliYMFYmLmnGAZn2L3QGIYKkAAKOABhgIIhUD5X4IQEqAVeiMIDqIVzCIIl4IcjoLhWQARe EwhuqMOBkLr7E4OJ4wVEYIcN2Ixg2K5xEAn8WDZXuDL1q7JkKIUv+EMM0IJWsAALODZuODYtmLhG uLtgaARrHMCBGIfkEohGEAJX0IN62D5u4ASRAEQfa4Wpa4VTHIyCMIdTpDY5KQZSeIUgIohqkAWB SIbS4IZBRMUqqAJ+KAVKeIReuK4sI0NzcIVgcIUKHIhRKwX/Xjg2eMStYAgGREg0DBCCKuMH71o2 g7COUTM4JkQEyKuFKmi8A1iGslvEgeCHWtDHbhwIXciCU9S0jLjImdwubqAEYpA0/eAPUtAGzagI asCTiCyIepgCkBQIf+CEYKgyV6iFYygBiewG4Aq80pgHWkiGVjiwUii4A9iANKAxggAuVMw9MfgG bqCFEuCHP4y/NhQIXnDEyWABN7NJiviviRyHchDAYHgENeQGeDyAI7ADgzg6xCyKhvg9AIkACKu1 eeAFiWuEFqO2KOwGeWCHgpiHXmCHb0AngwBKozMCElgAg+g3WuiFbmgdgQDGHbADliOIAKA6xxS4 uyMIoESE/3ccCETAAESwjpWohaYrDOWrBzDBrnEYyoIIyV7YAUEjiJq8v0c8ileYxBUcDDzJiDxU nQm4LUqguGtYB0ooumu7Px6QyAksQ/K0h3HgB3nYAIMgwokriC6cCR9DBKxbw/7My5rsS2zABYKg tHgwh+csiGBYhoIozi2BOVKIhX6siHciiFqgOgosiCVwgmM4gnpAgYr4AnYTCHNwO4MIgkobSnSQ yCUwhymgBd4U0IqoBb3rMtksjYHrtRndEqkjhgJtiFI40ZkQ0CQc0oIoyqQQiFejo0EAsWKwE1Sk PIPAyh2ASIEYh/r0Ri2VOJ8rM95UPwHsh29Y0Ms8gHmIBv8hgIAsoTHyJIpaAM7rbAgeHUACLbJz oAjAq8MHpQhYrAijoAYSGwhssAVqoIZYiIlDLYhSSM+CiIcVmIz+FIhaKEui4AI6LAhXoDptkDRK bYU4lIlkIMOCWAZAWMy+9EsgJYpkANPqtMli0AZqCIXtNIhKbLe7JLNhFIgNAMccJIh+IE88W4aH lMiKKM2ZsAN4rMXyaIUGpdMtsVMLbNVbbYgHjYF8iQVs0FZt0AUBUIYl2ANc+EuY04ZB8E7XWVLF 0IYovdBSWMRjRdHYfLyfI7M9CIWYxEMxODZagILXap1zmLEDGIeHHEBeKFahQFW/TI8lGNUggFeZ DIWHI0n/bug1UhgGhbAMy5BEU0jBYbjYgTAKSZxEkVUGW3CKTmBXmZw4zoTXbsBTg6BO2TxGijCy ZLCDHRDYVYsH5IwJRNDNvnxW/RAAb5jIVojZ8iAMduoDOlIGnMMGbWAEb7gJbdCG1CiGEQuFfUnK lK04Xsg7r9MzLNXVipBUVJxWA43KgC2IfijNoNUPTk1YgxAAVaVYfC0MbdiDxiAFW7hYc/XYvzWF WfVYPCki5mwIpVwJoBvA38yIblDbQ1PQ6ozchHXbyYjWwrhSoVgCxTCBQDVKZai1bQ0io3CsSfxb ZXgFzhGQjKAEeXjYVYvbn03CebAO/IxbNr1dgriJhkjD//IYAF2AMFKQ0HdCCo9ViFgw3H7ADItl V8+oTq6VyYFgWJ5sPATohGVtiLVsiGsYW9zNXe/93ssdSVT82YqICRCLAWrQA6rVBpw7SluIVUM9 iP6Y1YyABOiNirOVk1MrDX4wB+ytCLuNx+8F39zd3fjTXyLthuQaBmpAhVvgDAnd24ewBVtgTqOw hc4diM2Jp0Q9VwLOCDhtCLFc1EodikeY2bit3ML4S1TVT/2Yk83QlyJaV1JQSs9QVBCeCQGWiRWW iVJYMR+eCfG1SSEWoqMw14ywVR2OWyF1VR024pUg4m6MYkBdiCemYfzNXV+VSVqgOKRlYrglYG+N 1O0yiP836UZAfYVYM96SFYB4GhAmBuEoHmG/0+EWBtpXdbVX0Nrx0GI5ngwue+I5vmPDpeJXVQZ9 +eCCkFBAFohHSGCZ8AHt3YajzV06rghskNjCMMOGeGGiNAUTsIqB8FiICAXFICGbbIUvJuB+iC/M MrRtiOQivmOcQNUqVlhlGArQmIxXQN3/2NtYcIaMNYUKpohLVcNjmFyCQIftIo9YMIFZJaGNNYXU NdlYkARandODiIFXiIBCLVRq0IZtGAZbiABDbgg71YZXcJ06yOCsVQw+xgbtfLXEZOUHXQjhjYVa m1WT1eb9IIrVnQxqaFqqxTkBaN8BUGhMHghkCFG0xA//STtobGAEcWZfbdgMYLDoHo6MUzgAdRJe CY0ARP1moohWp/VWqrWOfqDobRBXfSQMbDiFAaCGp6W1psW5exGKYWhfyPqMRXbkyQBHgkBjEO7C ecxdZUDnLSnqLTEKg+AMf/boG9YDASDUAbgJbBiAYbBqqzZKPcAGYggAScAGsBYAQ8WGrObqtLbp rMYGS8wGYZiAbIgAYciGbCBUUqjqqraFdRCAm1DKrNYDW9BWsNaGzgBrFtQGqwZrUwBrbbVhbU1r rtaDbNCD/jBrXWjgxybUstZWyCrszi7svfXskpXss85WsNaDCGhfyaZsbeUP1dZsRvDso+RsnvZs YABq/4NQBkQdjwa+BUO2BUa4BVK4BecdiOA2BaXMj3cSXlvwaIIgoQomBcwgiEOtBpP94GwYBnI+ VHwF5+ze5CXVhuWG34IYhlNQp0ItCGc4hVgA6YKghm3Y270tCJzz7uCuzmLW7vHGBiJa7lvg05Kt 7wiILKKghvsdD1uwDC0JBVuQhUJI74IIBWB4tVj44MgMBQUniHc6VI8dDONVCOYkhvTmW1Pg090L BVkIBfcmiAF4LGowBVk4Vxf8PcGVb8h6J1q92E6wjGFgzout4ItFboG4BQb/j6e+E2x4tXImCF0o sX220KCm8iq38ivH8iwvjFgYBDtRBqogiKU+AFngUyctN/MzD+phOOVBIDFTiIGLDYUYgLESG4Q6 r/NQ0M46mFUVRPPvDQgAOw== ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/jncidjn020f02_4c.gif R0lGODdhZwDIAOcAAM0AAMViYsWsrHuDzc1aWmqci6SDg////3PFSr05Ofbu7s1zc8UgIEqLc7Rz c8W0tMWcnJyc1dViYr29xbRqasWkpKRSUr05QdWsrKzVnJykpM0pKdViapSLi70gIL2clM3FxZyL i96kpKSUlMW91YOL1ebV1ebm7uacpHPFWnPVOfYICLScnKRzc2q9WrRaUkqcWt5iYtVzc+bNzUqs QWpzi9XV3sXF3s0xKWpaWt7FxZR7e+bm/3Oki71zc+YQEJxzc7RSUr1BQZyc3pyUi94AAL0pKdW0 tMW9vYuLlM2Li805OdXFxc1iYu4AAItzc6S0rN60tM2cnNVKSkqkUr0QEJS0pMVBQayDg6wxMdVS Ur1aWu4ICMXF1c1BQaSsrKzelM2UlN4ICJSDe2qki9UpKUGsMfYAAOYYGO4YGP8AAGrFSr2Dg+YA AKS0tN5aWpykvbRBQc20tM1KSu729qzenIOslLR7e+YICM3F3r2kpKTNi8XFzWqLrMWLi+be3s2s rNW9vYPVWtWcnM2Dg9V7e8XVzb1SUnPNQZycnO7u9px7e+YQGMXNzd4pKVK9ILSknM0gIObu7lqc e+YACN6srN4pMe7V1cU5OdWkpN5SUqSsvfYACM3V1dVze83V3pxiYt7m5r3Nzd7m3t7m9r3Nxb2L i6y9vZyknN4ACKy9rP8ICM0xMYOU1bS9vXPVQd5KSs17e1rNKcW93qyUlKSkpKykpKScnM2kpIO9 c73Fxe4ACL3FvcXN1dU5Ob1KSoucrKysrLSsrKyspObu9ubu/957e/8ACN4xMay0tJzee6Sk1ZSU pLS0tKy0rL29vb2stM3NzcXFxdUQEMXF5ubm5s3N1ay0ve7m5ubm3sVqar29ze7e3r3FzdWLi9Xe 3t7e3tXezaysvfb29vb2//bu9tXV1dXV5t7NzdXe7qzmnO7u7u7u5u7u/5S9g+YgIJykzd69vd7V 1e72/+b25tVqarTFxc3mze7m7uakpN7u3ubFxf//9vb////2/6wYGCwAAAAAZwDIAEAI/wAPjKt2 oGA1cwUTKlzIsKHDhxAjSpwIcZw5hNXWGVzHb9y4dR49ghxHsaTJhKQYZkB08sA3fw8zCtyToRy4 A+BIttwJEV6DDAmLqWR50sbGgusuHpCEjadTk0NgKAs6tOW3gs+Y3Ty4VePTrw+jORtCZWpBoQqp FWAZKlEXOCRxAIrmdeHVhyfqgnVa6JAuawj2HIjWjKzZfmgT5unB8kSibXAPsNqhS2O/JSIS3mWI UdLeiHOU6EJ4QII2Q3f7GipBA8wBc80ilIV5IHHBPHZY6kvUDViKcqwWVS6IKVMnjZsVjrupM+G4 fgub8+NHJ/oBfgkVJcTevGD3A/6mb/+HXpD7wuoKyS2ct/785/fw4ydcp5EcE2792FUDV63//u+f fUSfJOzgU40kCqyTEYJBqVeQP3SENE45Hgk0TkcOjWPNQ/TJx5MrtXj2UDHl7DVOJ+NE8wxDHXrY UjMhKqdLNA2a1EgzDfnTyQHNrLhQiy6aBKKIBUkCzo5nOUgRYeQZ1Ag45khTC40/6hXkQtgwEktC /bCSgBtNJWQkabW149ARRUQhCUImAODHKbQVxF8nZLJo5ZUJZbllQf04IoQbUBYUzRdHJtSOmQ1F kcoH3eT0RyqmnALOHwf8oeBBdVbZUhhxaGAOSYQA0EEjCFVShAGi5GRCES3owh87jLz/4MYf4PRj yZ/gXDWFEcl8QyYP7AkEQjDPkBQFJbTwAg4df4jBRjL8rYNGAG5giidnmeK0XDRNKseOQv8B+Fk0 iURDUDW1BLOcOeC0+027ucJrA7zvumsvOOHE+269/N4L778A0xsvOJ/MO3DAAgu8L5QEKffRAet4 xk9OHX0kIX3YXRsRKd0yBM4XzWQMUSMPSXKnxg7VotVDPHS8EDjJNKPkQyTvx1BeKEvkTzOEJtRM MlQewMPMDFUTjCv98DNFG+g4RPIzidykEM45RwTjTYMcE8QpSNZGNJeOpPKFLiQtDckE2i1EskPs EHnlEZk0qckKgSRUyApY9DzIKltv/1jQ0A71KQax0C3Ngit3SlPyyfH1gwwa+CQ0tx61fFvIGXlj fcwLp/gttMt8OjK4NOqZPVw9Z2QiaEMNV+16Q01+nZBM4wTghyQq9vhMj81IDZ+KSLjywO7NNBNl M9IE47vQ3iWSSDDNPKBBurU8Q24zwSjeEDhxIjWKPEuFKfLrJdlW0EpWCQQOjhC3e4BM5E+0jFR8 mn8A+ifdBX3RjMc/uznzO4z51MKSajCjN+qhgAkechNwPENq42AHRvpXNV08QCE3igD9zrIQAh7A Ma6Ax4WMYABdnKAhL4mOzQ50rUBwQyFNWIBC+iIK1tRhMLEpC1UUsphXfDARE1gGSf+CM5zLqK4g KXQIC09CKYU0MSFLqIRC5uCAJxWkCdoQhTTcQY9YHGI1NFAHCq6gC8PwiQcJOcEXHmCHV3DDCCPo hhVUIAkifiEXdPCCBU4xCpd0T2PuW0g11hU4BYCrGhjyEDhyUAPsrAN7OInGRSZJyUpa8pKYvCSd zLHJTWbyIuG4gTU+SUpKdqJ1SElXUho2PvLBiILFCNZXLCJIFfHjlP5bCIzcxpBiyO4h7GpIiiIp p93ZBJW5HJJCxhQURFGkEQ9w2YkOII1EECQpncll6BLwBbeto1BncWZE/lCEN81sTpn6JkJM9ros FYJLyMAVmdSZEMAlihIfcBWzxGD/ClfwJyH8UcpC/OEZIMmHXeNY1SBmx4gA2CMUtfIToBCyK2iR 6VAOiQIeaKGLPzCrCM/iDx2mVS2B/ugrf9QmRUCn0pZKhJ1/OAQGcLc7aexud8iMX8sgAg4NOOOX GHwINijo0nqyVE5HE5faUuSj5hhUm83QQCh8Foyu+ZKnxNLJUUlGLIOYIxoWIWrO+BFVSu0tCNfo GscC54giZPUAU3BC0xrSiGgEgzTVUNE4RiFWD2mBbgmJRRvuoLfNdc6obB3cBArXhrOhRyHaawjV ruQ4NNRlbtD4guXw5gysrYJznrsq7MIWDF3AJK5n044P2oCLgqyNdX09yToYcAWt/yKDEc9o2OS6 eYBCcAILUNAcaOs5M2skQ3GCK+1p28CC06mBFo34RtBQFsyXWSRbBaEDO+LEnwq56AE5YI45CBKK hrFTqfIJj0n6kZK9YDcbXRFI8dYhDfrQB6wWU6n9MrCGlhilZN9axzOk0Ql5wKgW0gAHsSYQ2fgh pionAd+PskGpbGhkHAPYxAlgI4xk1EJ3Du7efoliknA4Bynug989qtEPfBDIXIP0XwB3qBD8meQb /DDHM+60xKIqBB4w2AN0HrwQG5eENNEAK07G+77Ykg/IgjkAkbPjDhKXxMQHeEYtkMJk+Pn4AI2o RQl0yMG0FMCH1UgEHyIwREDoIv+nOIFJ8fj3ZUGNZYNTLsgszvy+RFyDzQfAAS3qi0KGLOdcTg4S E0LgiqDdyIxlTgg1yNCYRITwOTgQjlfW0aTkeGeFvNRYIHQww0PUkAY3JIwGzVKbDjLmh5CJC2Us gwkpIrGV4Eo0T+YQBhjKQBI6oWErUI1D2bB6gK92zDY2IevhHKA4mhEmouXDCkBwKTSdkFoTKCCK /6qGNWKMAy8g3ersUKMHgvgDA4jQDTvQcTJFXIIUsn0ACXtsKfJ44gH24QBXPEwH//hCKLZxAG5U IRHkUQADDPBYVoDiFDVA4xViIQpmyOIeTQiALgZgBn0U4helGLMYE+CKVsxGyu3/NUEWEhGBHriR AczYhh1koYgNAMEVbpCFPpYACnuQDLsKScrupvQ+LbPvBDBKBkkU1IlgXBhGwSCIP8LxjLsKKhFE rxQfsicnafTIICCYgCsS0gn2eUcXCrHGM3w0GHOAAKDNEMZRr9QMXkCvFokQ8Ie9TixnYK96O8be F5DQiWwg/YF1TvxeqoGKZ7SyQwrwgw6WQ5vwXMhF7RrkONRLkoH00kGSBAd9qsEOOqyjKeZghyIM KUzP2ek1SSDwLaTBB2l4/SI7xlNWvjUiWT6Flg7pkAOlEQ0H7h02PQL6e3YJEdHOcrrn0XWQYMR7 hxRDnE6h5T811VIQwRKoDYmG/78NnW1pfMo7SJG+i2B0wvmA8wD48L1EbpS06NDI66/vfi0i534y xdIkXodrtKRlzqERTxU/4+Bh3vR+/zcR8gAA/XRO1vJ13Fc12IAHMsAllhAHvOV+XQMsFPEo/dQt 6BQd33QAptdOP7AnUhZPY1MX9JQkGUUJY5AMHmUCYuAH18AtAGUtwad+X6EnGihPCQFRH/hLx9Jc jgJS/jRVcuKDC0EjERMknicQCoENaLAlLOY4ROgFDAAongOC98RRNygGWOBPGYEGQaAB1UAnHAKE wqQdItAG8fAuCVUEqqMR1YAGsrIffYIrJlZR7yeGBaEk8YAs+tQsZwgOoaAAJP/VhtlCX+8jDRQg B/3gEXTgABAQEnRgCmwQEv3QBFXwBcTXD4UAALXgCiAwD1IAACFwV5KgAwAACl+QbeAwDRagAZ/Q CXQQCVnwBXWVRx6gAdEgDSGRDjzgEX4AAESgC42gCIDgisYTCugAAIRFJ9UwDS/wBd9AYBUxCsVo PBCjY88AHfT1VgPxB7lVEGXXO141IwZRPG83js+AdgegCMVYLCgIDirCeuOQewlhDnUxDo2ABHUh SV5BDrqAeK8zYD0SDLWQV9BjU82wkLsTDBNQLK5QdRMgD6L3ALUwd4o3khHBDolwfkG3adCRUh5i dMEQDLZQC7UweITxkrXQHWj/lBAT8AW2QCww+ZLPoGN3919qExN6KAx0IQ0ZcV8igV45Y08OoWDN 4JQF0WCRhBDgEGojuVMMFDNUCWYARpILUQxzJ5UTQTIKghTQ803Vp01kVQu+IyVO+DlYNX4RkWC5 9R3s5FLJoAG+wzNHWJfQ4QVOQGp0NRhsJyZtmUv84GE3gQvTAArJ8CtAdQVVcDTYsTRzxRCKQ4AL sZf610dndQpBw5UMkVz6GFe2gGUL0ZlmlxBtQz4LwAqbWRAgIpp84wYfyFKCUwtkA1fMhTgM8VrO sXRw+BRzUzcF4Vt5M1WjGVq/lFy/aTjOBlmLcy2OkwatMzcCgB7MKXAHgAKG/7WbiVVaZdNY1ZkQ VokVg7GYHlJZYXIAu3VChPBbynMAe8M5pRmdomOewMkC9qARqHNE0LdMx7lSyKCdkrMCmbVZWAAt +LkKW8A1NQJQtcAHUtafupCZTtBcAqoGQNAIeWVoNNIf9dck3YKiByAFRbAFCcEERcAK5FENYlAG 9JBdjjANSKABJDEHHSpVB7AATnAHGmAUYXAGQfAFGCpl6YAo8iAGo7givVgEGjCV/eAFbTACrnBC AXAGISAN1lCg4BKO+rgOhOEKMHGOuTcQDtQwduWOONEJD7A21ZAMXPc+5IgU0YAEz1Ady2FTDTMO zdCWTOYdgJoQktQ6NiWm1/+CPA/pdFWHPM+QDM+wkcJALPVVPM2QqOzQDBPgnp/xDI00GImAI191 Eb7iK6g6SapqDqraquFgA6vqqqxaq7P6qraqqrF6ETZgDbtKq7MKrMKKq0oxDqFgRbkGMR5AAKFg U+ySZMT3lS9yXNAqSdLwB50QlOaiEGgxEIFaNBHhaYJ0oFWTGApyJKXQH9HyTfvBOKyJqEngdNu6 Do7JDMMgky8JPczAqOXaMWBgZRSxPEUjIuZAKfTxMB/BDxyhXwzxr1aBa7NzYaRSDuXFLqJ3EaKn UjmpEA6bPyzSDGjaCJ4xDnDADKRgC5vEH0rpUvYDBv11EtwTE1rpUtIwAVz/0rIAOxECO64Q8wiI YGATcGBZRz7UkAKs1l4cm7MSwRw2tXQyaaYz21KzsAbKQBv2UwdKGxHc80g762V1VrSstrEJ0bEm AQ7YYXvf4bVfRg1UW08Nm7U8VZXNcE0ByAfkGiR5YLQ0lhBY2xIx65ngErUqxbZhuxDWsBYCUXyA FhH/tXYMQSCJdyPU4ALHthDn8Gpp1gutQBIMcAQ7i0RYEQxqWQtm2n5fZlcP4AJRlmcHcLkFlAia +xxGAAjH0RBYFoA8W2eEMbVRVm4J4bp99gWtUCJGcATWoJUShjx0plK5ohC727aRVhDnQGl9xgcl UB1GAATpCVCvcaf8iCMi/9pSjfAFrUMYJLAGq2s+54C4aWa9JLEBs7Y9EHsU2lQIQiAK5gBsOLQN lLu3B3C4aKYB1ou9JeQVQYABCWFvsKVSHycKD/AIqZYMJNC/f2O57Msb13sAJORs0CYnf7Q+NxkN oIonBCBDdvMLojC1QGG+FHwASFsQh1tp3ZDBRqBpxIHAcgIRaushV6AECiEBJrycIDe1riEWs0C5 MNEPYtu6iOsYunC9/LDBlnEFmSEn89tk18JrzdEE9WAPpPFxuqDCgxEMRyxAhtvEvDEAnCbFUlZr AJVSggpm8fkeJsB6BYFtUiMBcQAoQmwPN7AGYKAAkJAMZey2aTcJr1AOQf/ADF3QBzRHRJbhBVJg RThmlI2DCVEwRUrwCXkcBPYgNR9nD1OrDvlwARKMxJH2DUlwA2uBDwwQAtTgyIqQac52BVhgDTch rslaEfr2RjCYBZegEEuAAd+gE3MACroQDlwkAUEgCs3wCPdACL+gC39MyqY8wZVbEEiQCNQwCYjg yrAsyyTUDTUgC5LgBUDQKDixPTcpDSNAC6gaDZDgABpwDbVgA8LgAKXaCubwAA6QBJKkYw7ADKQS Dt1wB7ewDa1QjFjAKMCQC6rwARy1CblgD7TwAV7nDvbwAaYgDUigCu4AAjZgA71gA3J6B8HgDCB9 DbGAkW6QCw+ABVoKB7n/4Aqm0AHNwAx8YLMRYaa7IzVeF1nAM6M9ohPVYFNeIajXqp4TEJdIYA4Z oyJBEw7RsKQ40WDjcEGaYQ2eAw42EFl/4Arr+RDPwZLFaR1nnRD+0DHd8x0gwRDqhX4JQQ7dQQ78 oCT+8BzzoQjS6iHQEwzFqJTgkAjVRNiSuqnFmGa88ADZVnVfBWdiuRcCiBSRXdkUYRGBmpaW7SLf wEgBlmKhwA/kMWQk0Q+mvdbPkdqXuNqq3doCwdqrndf1Z9fkANulrdr+QAoto1UHoB79sNa9LWVS htqrbddm+ob1BgDa0AmukAjO8Az3mi6Q/RXNcAsQCZE8iWBSIgwIVk/B/yIl6QLdMpku5pAIwvAF NylMytciMVbXPkYiCnHFEQF886EUU7gO1ZMNDjlgtld1+uYhvLCOI1IiYDFMCqEAkmCwGiEJ1rMf dSUNCpBXUCK4eyENvDDdB4BRBd41LCIi2NB5FuIdl4cnNYvhhPgUOoLcLXWoIwJ+JWHg82F7WLzi bwYR7SB/PEHfSGFh93i3FS7g1od9EREMGqDeTOXWPg4WLG59BE4RPCNMktQMdzKFK37hyxQoZ4Hj EMEzcLwj1bUOSZWVNAvk7WNVLq5LXwDHCEF8BOFdKVjlqPRNVtXkE+EKXwAgwwRJFahNfBrnDEjn EuEKwfA107Q7HT7mfv9OmZcdBrbwBePTLpLEI6QbSaaK4TnzC82MSkYSmBOBg8/y6JCYZYmZfq+z DofQWqFzv4luKGdeEJ6eDAsxCpjyj5GY5CVRDSsINqoedAz4SyYQC/bWLM/SHej0TTt7gNeC6++U EH4iCnoh5wkRfzNIu+awT2ygCrGeV5lSDdizSq+D6yzYD2Vwv25YJAwo5AVxiBXwZorwKM9SfD1Y 7g2B7HgC7lwy7qmyGdCe5RmFB/lUhmwgKb7DiPKef1Wj7PB0v81LTXDpf1p+ABoFAboQCu3uLP40 8KH+g9+e66me7wegA1/a6/2+7stCTn7QhOMQCT4goqNkaDiyrS7SCKT/8wfFOzs/QAjNehP43ryw wACpYub9DgHdEArMkgonz4iOGACnEAqRrvHxoQOHQCuOIgZHdABYuEfwxYWiMApG0fPd4CsVyhDH gguuklA5iIbSovRQaPDrpRD74AflYOEHgAGUsA/vQgc4mAnf4AoZESsPpfMK3/U+L/IFoQi84Dca VQF80Igmj4YjpfYt7xBvbhIx8A720Awk4w14kD0mVgkblQyhMA7NcgfQkhd8aA8nUCvxJArVIPip clEOMghVAALKGw+s1Qihb/KfXA2Pfwprj1Q59gwYAALvUoyAgATtYg66IAdy8C42oAtMIAe60AnF GA1yQHjWIA0gcATm/9cJ0tAIRwACnGR7ciD+1O/RTNAJ1uD9SMAEjbD+z/Aun8Au0C8HfMAHURIN R4AE5vf9cjBgANEpmrQjD3qZkxbtwEKGDQ+ceNaslrSFzxI1G7cwWq1m6xZKahYs28I/wZqZW0gn mDCKB8a5CvZs4ThzwR4s5AcuWTMFJKU1k7RQQbBqDZudYKhgQseZ0R4EXYgkGEqHVa1exZpV61au XPs19NdV7Nhmz25Je/bgG7hEz2olemAyZMJn1Yg0ayYNXERprsKOBRxY8GCrGV0SRpxY8WLC6zy6 HPeY8WTKW5MkYrguWrRxocDRWTeu3DrQChyHPm3asWrTisopMh17nf+iyOsUlAYtLSE4c2vB2cjW aAK4UeBOkz5HzPG4B67M9Y7WCVyn582igQsHbnTs3FixeURXRcmoZ8+eD0womfI49u3ZH37fkAc5 h18z5+UKAus6qJX9L+TBvquqSUamrRS6yrEDzGFGL2YkCiZCvBJp6T+xiqEPq2piEhArBDOLaEF2 LPxvvqw2fKbDqz6sShL1SGTMRKwkiSm/GV+EUTFSMhwwJsOyYtGh73Icq5pQspKxxxS30s8hw/gj sqt+zOkkHKyStOqEmPg5cBzdMqqmvHHAQSrKrcgxpxFwGOpkAgMPwLLFYFzhKpoNi3KoGhzNrIqm 6xhC6E1StNrQrwP/fGBFnqv0e64qdvbks6Ep/1woUIYCzErLZ8LSggsdVjzgGWnwzKy/SK2aUs0D +lmnEbQuVbEhRWryqx8tnPjUKoWeCWahasxp5gDjTsUKzWi+OQAFNWQw5E0Mr+rHkTS+CNZWXEEN caawoCTWKmORHUSNWJq9lMf6ypiWzgO0oGQGbGv5caFHuy1MIHDFbeTNOBmKNg2TVu10h2boqGrX NxmSZERi+1Gxn83WDLeQfGGFFt1/1+UiBF3iXQiEcZ4J8iFIc9TijEAY+gMQEI49IOKJATRXUmmp BTjjjQuuRhqqwuzInJFhJMBkhgo5IwxDIFZjAXJhhtYRNC7uVGOO/w8IGeGfSQz65IWIDkO6ltWQ WN9YF4oWDY5qNkAXgh2qeiF8rl6sH18AwIahoHM9gOtO7l2gF2dj5tdpW4I9YAqbp277gHlzlBuP uhcKOoQJPNIbaaUFBZxsp4NJpmapD8BGHsNC/viAaky1sB8vuCA1aD3MKYrro7/uW+ym0bClc1sP P0AGNTJZqEKG3lOQcV9+ePwA1zsJypiiZw93gZcPeBZVwTvHOIRnMvIdl4Ua8Q71/1Tnor/lkaq8 5WNqZ2jH23P3fIKMFlDD+wOEd6j4ykjj9/jkl49d0XphOVHYjiE2cEUtVnU9z9ljfqsAhXQSpz+x cCMMeFtHGI6Qmf80OGJtqsNDWyB3Bj10IoBGs1wveEGxA5BjELTg1QKfpruoba93aoggOEIGDni5 yhw2MIc8fPgcKpmHiOYQVRjkYI5wTAAEUhBAOGyQECng4hPy4EMjcBGGhLgKEFJISDR0IYcwIEEg ukDCIOTgKl780Bo2sIEuolHFRvAii7gAo24a8cUHNGIgchgENDazQqyMYyAcMYxbHmCfaJjkSSHB UzXwYoOZ4AVBXgpGhYD1JgI1oxwLWcdP8DSOZpAqVKTyUl0YEo1nrOl7wkgckcYmKYf4Y5aF3Eq8 psYnk9hCFxH5VVsSoYG4RCST0kACOJjBq2ggJBibMSW9pImTmVQE8z8BAQA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/jncidjn020f03_lw.gif R0lGODdhyACEAIQAAAAAABAQEAgICDExMUFBQVpaWhgYGP///1JSUmpqaikpKSAgIGJiYqSkpLS0 tEpKSsXFxZycnHt7e9XV1e7u7ubm5r29vZSUlHNzc4uLi97e3oODg83NzaysrPb29jk5OSwAAAAA yACEAEAF/+AhjuShQcc0lWzrvnAsz3Rt33heUhDnzR7M5mBhSBiVAwTF4VAsGo3K4nBwlp2fbsvt er81SObg6WAgSZKFU7GgRJoheE6vHyQjHxn/1WQqaQdNFzpiGk8NWSUeWiRxdpCRORgHgR4VfF5+ IxQiHIQ5EIRPNhZykqipLhgeKyIVGpldm2QaIhOgOGKeLRQREA4dDZ0mp6rHqpS3Px6yXH4VxCmf hWMHERuKMo/I3ajKlSLNYH4UjRXUoRnMFxeBMLTIHQ63xA0WLBEdKRidDgOuvJFg9aYSB2PPrFFw NcGarjEVOliQ9uoCggjBVkREmKoBvRIe822IKFGDAwwcYP9UcEClpZU54Dg52xJvRMNqObjh0IBA AoYHBXx++Oiig8QRUo6WiCBBn4cGFyY0KNhig60SEgzggWBgXz8c4CAwm6nDz4SrRERVg4ABg4QN FF/ovMHhga0IGShUSBABxjwW9wBD7ctBAoRfMDI0aIQiwYIVBQhcehB3RswRZHM6zJPrxq5rG/qy mEDFARMGHFlUUCAhg4IBGTYEQIBPQwR8DUS7CKmEmEQGDyrBnjohwgoHDSSkfDGSTKMElCwYoJdh QaMaEigQnQAhtWYRpAR1tqHWQ4Z2lVvMdTGhQAoFQywE2ODAVoUIHjjobsGbhJkF+GygQAUNpCSV CBA8sJz/C1ZVgpZyBxQQnAYDDHAdDZeJkBkOFWx2y3hhjFHEW+mxMNdNZLxxkwQDeoCAAvPgc8BI h/nVwYKwdLCAexosMEQGb/BRwQILVkVVEnA5sAA9AjJQIgzg6DFOHxloEEgPINLwWQyloTDBT+1c kIEECGywgZgX+FTABa9dsIEBAySQAANiPiBBAmueJ6ae7RSQgJgbZHAeAwI8EEECAfz5wJ8ZPHBe VhigKeh5etopKJoXPLABAgEIOoACmlIq6aiXTupoa4BK8EA7fLYapquXhknmnhKIiQECrJKqq6h/ 0oGFBh45cAEEFlwAbBWJcAAVVS84oI9+GlygD3IWSLSG/z7F5laFDNVyYJK3F7SU0lMHABlBRMDQ 4MEGP9wmjEe5YQSkBcVacKEMGZT2xy8dbLAGB9VG8KRAqTBgQgYc/MGdBNVO4OwnG0CgwTz6gCKB efPo10EGuJiGcAZVRPDJRJWcwQEG6JyRgVEnYHTQwASrcWlAcHSiAlKpnYBWzDz3HIlaFkQQwQVF HqCX0dI8gs0GABzHcQLa9WBBG0NI4NEPDkvVQQVsMdJAA1zXZwXR9/ps9s+gdHDBYjJ4gM0BF5wx QEpBC/tHA/SpjdzZPGd4BzkeiofTAQ24FZcUZTigRQXe8e14Caxs1x3g4L2RzkNkmNbcNo0/7nmG U2oSOP8uhYDigJlljxa456wfAA7Jf1Pp7QimZTmDKAs5QEEHO1dCrDBXTd4NBEb4JMHxDNAswm1G J4CgAcoLBPqGN9R0y+q3E62PODOsl8pfgmgR2FKEOMBxGQgULb0HMppQGOVkLHe5Z9aYVt8MjHtj lDSMKEVCBBhomETEwKwSNIgC0rCKOYzGCB2AQxrUs4EfGgie+ZHnAubgjlhYoJgqGOgtOqjLJc4j CAbshwUs40REiDICvGTjAB2QgFQKSAKQNSIlGAjAPqpjiwLArAXg0MBYABcNm1gwDFEhkDBSVwLv 0YADCECB+VYQGr98RIgiGN//qoXBClxAbTQcwQZo9oP/BEimAgPAgwUsBJZWjAAWEawBLTxwlSNq aQwecEACYBcDJzZxALZ4AAJMoIAEdKATFmiAEk5YAvAtEIYXSOMBlNStPOIjIglQHwkaJIURJECR rrEFAqzTRkvEAgwdeuP1cOI2CEigdxPoADBMowQjkIB0cIADJXTEpAC4TAR50Y+NAgKIDhBgAEkQ 5DVSQgFQTAAgMNgcCSQAC0lKhzJgycMQqWSlPKglFBcIAh5pcKLA6ccDyqQQAoyyD9dpQJgv6M8I OiCAMTjAAPhIAAo84LwUQC8x+BFHgCggoAqgsyc/ZMH04DeC/NhOBltCZUJxQIFDLIJ/Bt0CLBAI HkZk/9QEjODoJZhooiTAbKItgEUgzIHS1rn0pWdr5qGowIS2vOWmG8CpTnPK0536tKdA/alQg0rU oRq1qEg9qlKTytSl+tQw7MBg94YQgWEg5nRqy4DI1gaBexxGW1GBqVhVIYpPKJKCfezcWNd6toi2 QFBdSoGZriEAAxQgJchpRgeMoyeofDFQnRBTVb+GDUZ8sQEcW1tD3MHWEiSgOIBogxnA0IydBrB0 ZLhUQh/RAAYQ4K5EWNshDxGNaGCxsXVgxUpPSSVVCk4dKVLCO16QP9SebaGtLQGKMNcQZ81WCcGg JQXwZtvbalNDgOsmghI2OCu1Uwa7LW7fRmCvPQDuLP/U/aYuQAEMsE1Vuj4DRyPiSM51NIICdryd NUjTPjH2wCgryI9awfsNMpCAAuTtnkO0gEvMEUG5nKNv39iHFOGJrnKeeGgMyuMAw/y2BcwVMMEu VpAKTCC/27BGflYJWyVYjQVfBFYDruLHs2HDT0Fz1BnCy4LQzWJ0CobBlh7sghJDYn8N3V17l4ec cPrBWWFEBjjS4OKEPNIgMX5BeSAwAZKS4HT6819SdnyNJbhDO3jTZDde14ki0wRhaKndWtCwkrhQ AAMiJob1vueAle6OhctzQoFMUDgtC/mNWsBwH/OStPRC1FhfFMZm50sHeWaRyiITxD48AIH0JYaF VKT/cTYXoWd4wHhwEuFd29KkvyuKD9Ep8eItPmDnGUVPhhT4ACU4sAACtFQErMDRheHnxhQk2QW7 8ADR9CCz3WljzU/0iIzgUqMXgA8C9gA1civxmGgmAa3E7grcduTkFlyMKCcgtH4RbOvBFSucO1CP tlnAAaN8hJrF3s1HGmHoKsMaDv9kji3eKUbzKAAyD/jKDSjBP/yi0iHEiO4FlYCB8/yQAgkYdwn0 s70gTACe6gYMoi/ZTwjcO5q2OJoIRgIcD1AgjdmZtH2t+4VUkqAV2IOoNQoTuI09oX02hkHCpGWC M6S7BUbB0cTohCmLKJItSegAqTHOQQhYcwEuF/kG/71cFo6hxcqYhUfGGxFzW4fyAAiIotXwIwZ6 MdI/HSAmsAhAyPgEIJzC8kEHHM2c6t6iXBGQdnUY92rXHZfpmgHwFW7dgl24EhuS5gRqoLuBAgxS A/DRAAMgEHaWGOXr84Qz4ZwnnQAJwCoSERuEXqBVLRA4AwlQgCiDAxeRT5OhnIk6crSBlBVwICDr sbAKpBDLBMBmkgDiiQaqNeKNQV4EjhwBVO4wIKwHQALBANaNhhVNqnRiAx84PHzuUHfVNhQTDE2D wEMkMWzkpQQWNgFaThSVMHOAAArAhwSQOQHK4CKcFsDA7wn3EdiFJJ0VOpMiETtDZ7MgK0NwT/lU d//ZITkKBw9yEB5+tmB4BBXfFwP8JAsNwVFwMAEL8AHJNEgQIBkUICgpwBdW9AriIzELYE8KcBGK QQTKIUtEFwWeNB0zInoRUn10xAmspQlycAkJVjoxhAEJQE0uAAg4c0uBowEBYDCINwYNQAC2gDcI JH8h2EjEgk93QAASoDaEcGFBE2QzMm8BEXoGhQAT4mqmhxmo9yGDA1EFMVyoQBqocD+SwDaRQC6S EEtzoAGUgIfSsgRWUDEYkQ23MWIzYDcJMw+ZJzSLxQNWIBFDw4WV0E/m8QcJ4AfgJgKglRv7p0gz sEeKIQqJ8EXKcgUtUSzVBjmy1AaHAQxCMw8nEFb/EvaKjlN3sKgCBaACHNUJLGUvHrdAvIhA62ZQ wWA0ZPBsCFSDIrVSHieM5rBoXWZQsgiL3sCLZNBljFCNIcVA0yiMrrMc1tiN3ngYDuAKiLRPzICN 1fiMPkMgq6dp0NiOx1BR99IhjCeIjNYPCBQNeoFA95iPpcWP/tiPAPmPAhmQBDmQBlmQCHmQCpmQ DLmQDtmQ0eByxKCDAeYARsAATYgXUzNSRvN6HkdvgeeO4CUGXGMbUiUD+TM00YICwxcyuGAKGGE+ VTVG6CiSrWMIK3MCNNAvNtmTXCAK+aEFg1YJ5vYDiURQLUAIVAADlagamuiTnvMZUhAXT2EaOFYJ /0MAFQPwT6ZQGLexBLFhG4m0eQkzNPxnXhuAWBKxDhoAWtKVJm9hJsczfz4jlUGzCHuFETdSCW/D A0sgDtUYDsm4QCYFmObwA4/Ei4jpHKXIOrilCf0QWdFgASnHgMu1QQGWAi5oAmuwA70DlVDCCWZI JWiFXpUpY4Sga1VQiinpFhDiSkDiL8USDO0geaAJOYz2RgdBDjm4HP3lGaCAN7bZYnNFiVLlMBOB bCzRA69Xarf5OtskOtglAm7AdyzwTQ1Gl0N4m3WQHQXxTgcoFwrhm9ZZAobwBMQSF0wxS1oAbNzJ BUEUnS9WRHCwgDIGEYnAetmVMfwQnu8Zmtfhb/+5NXK/OXBlQJIvQHX++Z+r0GKVJp6qsxZ+IARD yaBf8EDi8KA1Zl6cYJ9KZg21cpIwwE8LaqG4SUwTUKJNpGF1VJ4k8E1LU6EmCp/UJZ8JMZ1p4aIj 8BlO8JnowD7fqaIzSn0wZ2Avxm3bd0cikCbPBQf0wTC0BAEFIKQzCg5NRnKiI4S3oF3AGQNHQ4HF MKQ0ShECemDckwKn+aGZBSyfKW5iugWPeaS6paMIYg0To51kYEtvOgkNlaFn2Ap0qgTW0DDkRKUm ygpoUVEaqh4apn2BumSytQNZ0ElO+lL3oQ+YmAiNGQlhYaNfhqPVWToHMSkX0hDBggJSaqg30ED/ rNoCicYB9MBobskzBWgTRpoQ3OahuFY/OXUhU6OZSJGmhcaCFdhuANQtU0FALIYgntp0m6kEutp3 +9WYVVdoH/FRxhpqoMABQ9cz1gce2DegaRCt1/kH3ScwbeMW3tBu4PM/TXFIudF/3uqgZ/ha29UQ vOOIwbqukqdFLbQccjAk0eMNfrOoJnJp4AQ3bkFDJpU0qkoDvCEN/ppFgrIP/SKv02UJ4Wqm2pik 6lUcXyOH4iAK80BLX2KwOQBfbxQRiPYGylAB8TZdntCseXcl5GqeeeEGxHIvYkEs2ykPH4Fsh5YP iEUYDDMV0ZSWQkNYPgQG/YBtt/plufqodFqt/3NgFN8ZS5LHPHvxAxDQbMxxJDMSkjUQFl2Gso7g dNn1qBBRAAVHtrr2sDPAG6c1sdfQY3QEMkRDdLDgSZrCAAqAGg9Adm0kdmi7r7XAYf4VUqypoodp jTHQbsa6DyeTBP9Qap0nUOXCrc7DAV1RevvWp8t2YI3gUFG3MSIKmGcapjkARbXBPLkBA5Lbsp8g RMixAaXGSV/oPF+rSBdASqFLafXqsX+2cSSyCO5CSwSyoIXxNfmRLzeHQusmfIhWPlFRBrNaFW5n AuXSAAvguwsQB9U3ctN4uHCwXzuoDmwgNKmbR06wmq/AvIbECMF4l8bGjkbDsvngBCyISbl7Ff/P 0RdsAhnAawPxObrzKQ0Px7ZGs2ulaLXkxgANQwWPF4VOMLRL8UolaxKG4X8lAHrQJCHrQoNFqqrc gF5oCFvvtHsJZQohRB/zxnXzh7VIMTFbmxLlRgYWwHYMUiSd0MEijEZsFLxKQLM7obbUyaUXFA3s +V2tiwAmgRyxpFVReKWEg2gYgBzHIgpc2CB9u3EE8ACXMACUEHL7tmGvkKK0xhBUiyBk+7N0cRvj gkEQxx+601BPQWVz1kxw0K0uoBiNoH6AcHSSIXKeZ74HU5o3+6LWoJEtlp97yWiERnu0F0sIsBDS wj5QaGz9CiQKQABdZQDw4RRQgbFV4YWYoRX/RACDUFOGWCqnt8TA4dNiXxRLh1SpMaDGkWQLgBsj G8cDMzy9wLcAg7QaP7IcQgK2f6w4NjEj7LMk5bIATpJNAYrIa0a8llkJdujE8PAaSSCGSsCBJMQB JmQjlrA7aDB9FkDMeKFIDWbKLNAcaJVD1LEASdC0RPxR1sxnSLHIO8pdiDMDapzLhIB/6wQ+6DZ/ vCG0MHR5q0wPK8ZP8DawYvSZcHF1YqhvNnAxJcybSMrAvkZl7DFfRsgj07eEQoQNegGC9wtzsQQw MAh9V9gOgnC0XUxGB+AYo2cChUzEJIN3R4yjYtZhIHPHmQkDxUEhAcgaubEPZ8YdwewJ9iAA/wEi gw9QG6ygBMpcFSYVCFYRxPBhxhtNYHAQtWWRgPLTxuXyTheiLAQiiGhKAhVQAIKyAQlwHjk0Bh2g APSgKihAmVSk0G2WY7IUSi6yJlTQRRXDhYC8ozktxmiEB/+wqSMwZEZcPXlxDv5cpx8iefqhRHVk DNunH+vMJAPge4oUC0sQ1SBhz1gnffvgSrbgAH58yikQEEBiTdPxgAZMryWHsA/BCBOwEDLabU1E hetnUEBBD8CCG6ztHw6QdYSkGK9nHESQZYnBeilhS5U3IwVctr7NsTYhrH3HXVe5Z7Esmra2AciE TgXgSnvFaBfAEoLNP08xISU4SWeXR2TTAf/ZG8+2kIzA9LtMMiCg29vg4ae/rciyvAYaDQMubBPu EAivh4HubQILgAG33FVEwNrDDXyRpNcLwHg+QC+VYJH/q1D7UFAH8ADfTQMUppsmrGG+Sd7lyodv jMspHB4XhgDuMQEKUCWLVyCOF7v3m7WFA0MAcgeXF0tU4DCbxyAWzQDtLd0HDt7UebbXhRahCk6k sQTbK9dfkwY1ES1aqgTtkQIDUD6dcj98XMfSO7MioEcDoH4fMFwrACye8AAUDUxEhhlNVgA8MgAf kAMx/gq7+dviQJ5Rl8squzuP9XoqMOkPR+lnQcmVbOmT/npjUumSbumvFwWzp+kqEOqbPgH/n1Tq oF7pk47ppy7psP5w703qrP7qnn7rzcnqFlCLua7qmv7pwH7qvi4me1rsAiEyxOoCNXgDhEUzZw4k zhlPblAEvPwJPQBMJTEBXhQtCcVPxdLnwBftq3AFWlAlAR4ze5ECTdFgioO7ICta3BEuM2AUuQEX piAM850FbkIYDrg3MIBwI5vF53Me9UEgeKBVAjyci4CRcJNIQyMsouAveTQ04L4K2l4lunYYxqIY bqLtxv7x5ZLjID/yUGkS8yDy0NWmFUTyYmUwXxIMUBouERMbG6Ms2SAmDaYh2EBTt4HwaoO78sIx 2M14jEMaEjEByZMclLkycsvy4FEArcAuO1lsCv6SL7khBg1WbmoT4ciHLOeBF2IwD1VvFBwTGklg 9DOSAlXgL4YRNPcgTU7POltzA9pRNMxMXyEAADs= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/content/vol100/issue5/images/small/jncidjn020f04_4c.gif R0lGODdhyAB/AOcAAAAAAJRiatWLSjGDOSBBKTlSUsXe3v///xAgORAQAHNzc/b/3qyslJy0tINB MVpiaoPeUikxKXu9Qd7m3qx7g83/rBgAGEFSWlpicylKSik5QaTeWpSclL3NzRA5KXukc/asexgg IFIACDlKQYOLxYukrPbu7nMQKQAQGHN7ixAAGAAACLTu5sXmezlSWqSUc73NxYPNYqzFvZy9vSBi Ke7u7oukYouLnAAAGJSspIOspL1BOUpSYvbVlEFinEFBUnOLnIO9pFKDUlpqe0p7lPb/pGKDg3Nz Qe7/3iBKQVJiOQAIEL3FUil7OaS0tIPVWt7u5hgpMc3N1YuUrKSkpGrmpBAYGJzFailBQWKDe9Xm xQgYGBAgKb1iQWJ7ewAIAJSsc5ykxbSLe97e3pRzWlqsOWLNapSLpObe3iApKYNaQWK9Sr17QQAI CHN7g3OLi1Kkalp7WikQGKSkYmK9rEo5KQgACKy9g8WkQYOseyA5MQgYOWKDrIOUlEpiatXe3oOL lKT2e0ogMVpzc2LeQe727pSUYva0tIPVtKy9vQAAEHuLi97m5rTmvUpSWpSsrCAQIAgICAAQEBgp IDFiQXOUlL3N3vb/xYucnIOLnItKailBWggQMQgAAJS0rIOUc3uUlKSUvb1KahAgGHOLaoukpHN7 c5ysrPbuvTGLKZykrHOLlGJqapy9rEFSUouLe5R7lL29xRgYGAgQCGJ7pGKsnIO9e6SspCk5c4Oc nJykiykxQd7e7hAQEJSkpAAQAJS0pHOclMX/i0FBaoPuSkqUi5ScrO7u/1Jii4uknItig+72/xhK GKTNxc3u7oPNtAgAGCApWkpSKXN7rIOclKS0vaSk1XuknHOUi5y0rKS0/0piYoOsrFKUSouU5vb2 7sXFlJy0xRggUoO9tNX/vfbVzbRigylKahAge4OUtFpqtMWsg5SstNXN1QggMXOLvYukvUFSlL1z iyApOaysxQAAKe7//wAIMfb/7ovevWKLlPbu/70YMd727t6Ug6ykSiwAAAAAyAB/AEAI/wClaBtI sKDBgwgTKlzIsKHDhxAjSpxIMaHAYwcyamTVKVInO50+gvzRQWMNKVISscOWxcgnMFfM9cklo0bG GhpCghT58WMkabFkARhKNM0gJwcK5VoEClQfULlyYSqFSSo1ClOlVsW0aFHUGn+M7CI6a1KIEBEi RSLKtq3boRGU1PmiyIIFOQB6qZFm5a3fv0SnaBxMePC3A99MINZ4GPFAjIRZ2SEawVhGJ0ydYqI2 82mfN4tm5grQZyYmTH1aKZhSY8QKv19uhejUdpYrI4wGF/rTwUkHGU5kaCxXg+opGSURN4ZxYURf twnWAgYwawmnEydoAQslSp48Bo+S6f/Qwc6YqnX0PN1SUEechUghpE9v+6Kw/fv2jz0uzIpomxCL HNCBU9RQc40vUOXC2VPUYJJMDeV8Y8laIaTghyOgdDBBRn9kIRRRdshGW1vbeEEEMteUIcERXYjy whtU9LDAKb44IYAUB+wTCz0cxGGIIWVccQ0RRBjhhXxERcdWCFsoQcUZYahiDjCYvGHEKQfwookm XZjTSjWYhMGNMebsEM8N9NAjijWh3DCIFzpwQIUx1ryxhQZIumUZfnzep582kA0m2VtWnENHLZbY k5E9gRyABDHXBEOIMCCU8wMAEeARCDGcEkKMp0g0k8oS/t0iRxt+LeFBGYbw48AQRmj/Isohy7SD SkbloAKCJeWIMo0m98jBTxdMpPLhW72sZYUsS5xAAjszlEAVBposAos34ejwwjpMNHZAEUWQc8kl g42xDilvcBPGDrBUokY0nYSQCZtTuDCWW6H0qS9hfwaqkQLzAdBNN0rEsQEMgQRSBQTCFCGAKBZw AkguWUxhgQg78AUbA7K89tcsGwiwwzWr+HJKCjuYo00D/vAjyi2n6GBOKPJMkYk5oigRAmBKajCK BdFEYkEdsFhzxytOeUFNC5cc008g3ziThw5BPGPLKddc0ww+5JCzTCEbZDGVL/8sEkYoZzggAnaC qCGJWxzsK3eO+0U2WVsrjCIEM19E/0FNIneAw4gzEtjizAH4BPLBGmbscIIAhAQMgB307BywFTt0 IY8v8ojijwQSBGND1WsQ40/nsHiizA5sbAFYLyFsE0k9nMhhwT1+dFYK2Vm4koUXXmDiiS/ZXBHD Bhs8cYUEV7TiSRhP6IBJCafgoYMq1CSD2hBbDDOMIMooMILlRMU9t7798tcJqsPggksTTZxTTBVm mEGMMIGY8UEg9iBBDiHMAIAgYrCDYfGDDF8IWCdicYpHPMIXOYADDZqghCKgohwigMTFTrADZYhC DlFQwj+6MQS7YCoGHHiBHBzwK06ogBWDAIAFHICKInxDCDQogyvyNJSfFCwVZQgi/P9SkQr40SCB ZAHAL5gxQSIOoAl6mEQkmBGHbaRBckOpz/n6lL4tevGLYAyjGMdIxjIWZhna8MYwHqABO6ilDWoZ QhS2gaWkSAEfB2BEKXIBC8X8gRHLOEwYBqGScHhhBC4wQh/Y4QsvNMcKktjCJmTRkU58wZK0SeAK VqAITnISGiuABhzbksBSmhAApSTKFzxyyUisUi2WVOUKPAJHV6pllevriBtvqZZI1PKV64PlK3tZ y14a05i1hCMcv+DGVQJAA2HUjzdw4JYVDGETWEiGJbSRm4z0gxugqAQToPAtf5TjAIfwzg4cAIsu gAEbMahGNZpBByJM4hd7wMUeFMH/ll5cgBOSiMIWZoGCURjhFt10Ai7QgY63SQILwahFPljQD3uU Yxn2sEc/8vGMWnhhCAtFByfQkQuU/IEP0cCFQLcgCVS95SyciMQSZrEHhqIDF8UggAv84IVBbOMN uXjGM6rhhGa0QgcSrUYD8jEOQqyhDEQYQgF2cY4moCMaHpjHSNEhDg3MI08RiGYaqTmUFcgCF7so RiP6gQ9LACEdDfhDDSxRCHIgoRw9OIQTMJCOcMBDGWywgRLWIAQMeEEVjwCFH+AQjxGMYg9B8xgA zrqHLaDACldyQgN84QlElIQcFSAHCLqwlxyQExWHqGGEilAOf3yDA2QQgBA4UAEk/zCiBH+wxzOM UQIInmIQKNjCFjKAibeqIwyecEID4WAEJzi3GsnTxRWcQAohHIEUhgBF6MbTFFBcIxegWMQ1uBGD biziFi1gAjh6YIMCNKEbp0hEOE7RgD5gYRDP8AQ7HpGNR0wjjGicZln3UIxBbAAJgUDCCCYxgDJ4 YAtcGMQpzFCGIyggCnOUgA6SUYpnLOINpQBFiQZBhCZQIgl+GIIk9nAPaBBlCe5AQDGCMIMZNOMZ iPBELvoAgX4cQFc9YEMdaFECPqRDFF3AAylyQYYp3CFkYhgEJ9Qhg0zE4hv+KMIBAuEEXwyhD4iY wSnY4QR1xOMU4egvKNxwCuc2Av+Pywjtt77Rgx87AAecUMAcXvHUTLzBDfp4wyr+3Ic8XAEcYsDG BfzAzkPsowff+EY/KoCYCcwgH07Ihi92F98w7mOsRNlFOlzghURIwQc+IMFSbXGHFsBCGhEYBBlM 0YcXsMEQr3hFFwRwh8I9A7xveMUiwkELdyxhCdGwgmRnEYVScOMZ4yhGE4hQixzjqGsOO8Q6BBAA ViDDD68QQxeuwAQ8rAMPZFCDIB5ABk34ARb+0MIVKiBpcrAgH/ngxi4wPIQH7OIaOsiGJ8aTDQVQ Isfs8IQBhNEPu9qjGfBQww8s3Io5gCIH1MjACAKwgx0MYhA/CMEGYAsMHojDETf/SNQ67tCICvRj BmFABDei4YVWcAMYAxcOGKVJ1mfSNxEN8IIveMEHWvCBBMiIBjUGQANDdGHXORAAFTjgC0Ac4hAt OBgM8k2EEWDBBSFYwh4iIVkApOERB/hDLv5QiBtswxfc4GgJqoEPYTSsB3jYdYvYwAY1ZG4HoggA exwRAF+ktwV2F0ZGnIFvT/S2AdcwAD4wEdxmn6KBNMqBzIHnijwQwxfUAMM/SIGNCx1hDjkwgy3S MQRZTMIsowhBEtYQDDCooQ7zqAMZADEIJujCFxBgxjzecGlV+CIXyfDFI3KwaQCDeigaYMfll+8L TDyCvuzgwzRo4Q0+1EICMSDG/6YURgx8J+IUxkgHH94Bj3DkQg/RmEXZiYIFNPuCHYxghBQssX9t TEMd53BT8QAPx7AMltAPiGALT9ANP+AK26AGgDAEGdANZgAB5NAIUIAP2lB06kAL6qAOf4BRHGIJ +GAMACBcI3Vss7CCXLAFo4AAEVAMtUAHOhAMTAEPzxAEmCAFrSAFE7AhB3CAeXQBgzAGMIAEnkAH QkUHiPAMB5ILbxAHOYVhEeCC4iBSLDYMnlY3ZtSFXviFYBiGfRJpx5AbNmETi9FFgnI3PeQHMIA4 nwGFTeEVovEUVWEOgMAZoPAGT5EIiOEKf5EA7XAsRBE7b9APidAZOwYKW7Fjff/gBkbQZAWyGVBh Gn3QATVgBBoQAYUYCVYwC0qCRSvQBnKAHcowDtVwHL8RJ2JADwpwAh2BJ1j0FoIxN+VwTu3wDe3A CO0wASZwGGq4ESMSCW+QEb7wBk7hFOAVFXYIXn1QCW8QAE6QBp2wAtUIACHQB7IQCRqQCxrQC7Iw BM8RCbcgC2wIF64QDx9IC9zAAohAB1WQD1Uwj1XAAoHAAs1Aj/pIB3QQDERAC7hQD3aARG0RirUh CyEgCCcgCMjgBaDAOf7QCIngCxQwJdQQAZ2QAFOwCOYQAJbgD7FwBj+AAWcAC/HAD2mQBvcyH7Wo EUUwLjAZkwdgAugRCwoADqH/AA7VIAVocADBmBGsIFkrYAXRYAxppA3vyI9CRY9NOI+BgAdMYAP2 UwXFAI8scJX2Rg79oA1L4DHk2DHIogfFEAeE8A9sIAaHAAKHkCsHEEgHAAJ/kBGH4A/t0FrygAcS 0A1rQAD89BahGAIJ8AMUEADWQAXswA2qIAZiQAGwEACyEgChYA3e4A1TEAv3ZgDsAHDccAo65g3m QAFhYAyPMDwNMAVhYA3DAAmy4xfmkxFIYHcVIAyhFS4veQBoQAUKQAWxEAvtsJtjkBE/eQAAAxgr QAOpsAYTZAMbYAuBEAT7UwRzKQKdUAfgNQjKQAGikJ3y0APCEDmqxDHT8Qty/7ADCjAEySAlO2AN 1cAO37AAINADhnAKoTAz8gAELsAlTDAAr7MWvaAB98CQe5AGjqAAaNMH62AIptAKMhADWUAK95NR GWVvsZkwfyAFwlAIM8kAd+ALxgALouAA7uCCPCAInPADs4Avg4EP/dBwLKqVWolH7dAOuikFYxAL 1dAOwMmF/9JJb7FJBFAGzFAG2bABB1ABVYAJ+dAwDiMK/CACIuAA5iAIKPAa88cWXwCexBkJZLAD QCBuXTAN2EkCobAOL3AFV5AHi2kO8sBIooAHcDAdvRAvGmAB6CAHdWAN1oBxIUYKDOALvpAHuXAF q0cV6TAIWQADWnl+x4cJoP/wCTGQC9THAYaQfI8AD2dAD3wgDnVQB0NAkFnELwUYqscwqsuQRyjh BOtQA+0wBoaAoz6poxkBMCc6FB7QDR6QCg82CYVQCDLACAhWC33gY/iACE0gC0Lgd2rwHAFDOSFw D/cgDk1QC8VACGZArYFgAxLQBfxwAswgCDswn1RwBWvQDQHQCjlgC93ABLfQHaxwAXUgD7p2BK5D HdEQDejgDuLQCbIwAN3AdJEgCGlQB9JABkdwBEYABKXhXTnADcqHGllADfpQAAUwBBLwBOcaA1NA DaCgAAVQB2kgCBEQAXUQAdtICROEkW2RL10YnBzxGo5gBVHgDkOQAnwwBO//cABQ8A7akBEa6APx cA/1cA9qAAQP4AWnAAMG4Ad74FJ/0QlOEAbsEAy5YATwUwxJAAeEQAgS8A+3pwSvoAFR8GUvoAQS EAEiMBR1UAbhFrIaIA0voAZHYAgSUK2qRwSUgA5iV6WzuLd8SxRaZEbBKYaCO7iEW7g793xtsQs+ MwQ4YhiM4A0e2A5O4wxXyQLwKI/PUAzF8A4dCIAaEAeCJQ2TsAuSBQlhF1xe4ASP4EgDBRpqwQXy V3/SMggXoAUZ0QEB8Alv4IcH4AQNkgNesASRsAVWkAsNkAx6cGy78AanQA1R8Daz6IkhsAu7MA/i YAVJMG1JsASS0L0oEAK9/7AEKBAJKAA/ROIDKkW9aQC+etsWnRBWYBRgPTcUdnBNuEATf9AMLPAH 6fCQJbEATIAKqFUO1nAGAtA5XVAHGgoMMRAGDTADtbANcXABwrUs8/cD8bAHIeoB6VAC7NAAidAP zqBR7kgHnpAH47oNqqARh5AcRQoBErAGtuAJ44AIjWAPeGQJmCB9RlAd3Qu9/bkJUaAHGVAMRlAN aeYLOkAHmksJx0lhTkwDadANplA1OgAK1KADBcIBTtgNNDAJI1AGA+AFfaAHUUAH+qAHi4Zf+YAI JUAExYBheLILYiVgQyEOtUAJOlABG5APXXMAUpAHQBoFWWB8sHAEbpAMXv/wXjSgB6zQUQrADqWA BYvgCZTgAZugYvnUl0NhBZTQBJzgDmYjZpiQCJ4wEx2AbSCgGP7ABqGQC/JAAV0wBVeAbnUQAD9A AmGgDkOQBUeQZQewAMLQAYmQDuyQCDOACIiQDyA1md4AD9rADlBLX4iQDb9ZpM0ADi0gAOFQAqDg AK7wAncQDGtQCXRwDaBxDaCADYiwCh8QA0dDAWqQBbqQA/KJBzDQCsJwGGMwBFVgMteXA8lwXHV8 D5zACfewCe/gA9NgCZaguefbBMzACflEBA7ADzuADd1ACxxNC/pQC7SwfetndJECD0OyB5AVDSG7 Fl8gCUNwCjnAXw2ECIv/gAnAAAELkFd5dQ4RoAZkwAZ4IA3M4IAPuAtkLARMwAbU+wNboA6MYAI9 cAnk0Az3l1+b9QiJ4AcjkAuY9wjccM7V8Ag4gg810HKXsA7+cACxgAvucA4pYANqYAq6IAGEgIxu AAi2QAhZoAR5sA5UsA6LcAFR8F+xIAAtsABFStaJ8Ai34AsXoA/5sApGwLtfJL9EEX3R3Ap5NAgj sA1EEA8T1ARxUAcOEACvcA2bgQm6IAZnCQtlGgPjMA6OMAReIFDdew9RwMkAMAqrMA754Az4YA+U 8NKP0AfXRg4/1gMgAAiA1U5i8NPBUAld8AqV8AkCcAa7oAZdoAls8J5S/00OWvAM+cxUz4YI5BAM KNBsTkAVyOcGcPAMt/AI1fAMZcADNhAATOIOtKAGaqAPDHAFmDAE4QUK4+MKcMAMVjAILQACnkAB DiAIDnACm0AG/nAF1GALefAIQZAPzrg7OVAKOUDZXvRpdgwAmxBfrQB0EmsE6OsDCHt0p5APtsAE HMAG4QAIsCAA21I4zaADwOMFozAKUSAOexBTbpEG2KDZecQIHdAPrTAKBeAGOYAJ3EAOiiIghEAN d8AEpGADAgACLQCVo/UAI8AE1AABXdEPjcAOSJwIgxAFBNAMSdEB1+cFnBANUYAMD+QLvYVjbdzG 0mcMpjAErKAPT/AE+v/QBKmQBlswCRFACZQQBSFABEIwFX2wDcb5ACUAAYQgxmWwBjEAAUFwf3t+ aaVweXuk5F/0J4ywAO35DajQDzVQCDWQfyZQ6zWQ67qeGLde6ybw1L4IBb2u67r+i5F27IrBJ3hk uPeRCD+wCZugAe4TDYo7AiPgB9+GDBiADEMwBH7gBw/gBxcw7iOwCbuwCQXgB/pgxLTgAriQUrig ARpXABewDRfgAhngCovmBxjgBxqwC+/uPvHgA8hQAIPgfIDC7Aq/8AzP7H+yD/Zx7BIv8f4yN99Q AxOf8ZGGGPSgClTw8R5/ozWAD9/wBxVq8iiP8r04AWgwBin/8nH5DVL/0AEfPydOgApSoAs1TwUe D/I13/M8//MfbwxU4ARF7wQMEAtGT/Q+3/RB7/RAD/TGcM244g/+IABWn/VWfwDt8IbtwAEy2g7g EAsY8WnaAPF2gzcjUIt/4Asf1hR9oLEzobGj8RTddQ25AQPK6hYRkAZYyhZpMATZcAA1ABXU4BXa w4zgtQhGEACLUAqeMfeMiAm96gV6MKuRcAQRcAQjoBZ72wmi+wWleAI8MAIhq5BrEy91wAl92xaG 4IVodPaFMZxlNQI48g0lwIdw3xlx/xSgEY0Jm4y54At3BAh/EQkMMBttoQHbsAglIQWnoIwOEhVN MQGlegi5sApSsWNe/8GoydABUgAKGXBF0MFDfjELkgAJciAH00Bfp/AlOaADj9AK9BAKxtDYjnAC IqAHK8m3e5IRAGGiXI9D5QwWNHigXKwDVKTEWndMisMDx7Rp23dA40ZWdgAAsPLm2wEnb0CBypWL GqhFuU5igklNpTlqyUolG+SoF4BIgJy0c/RR6MdOt0J0GspTg4tBHTYeqHEgkZQaMv4c+Pat3D56 f+xltYpVxqlt24ZESfoxQaS0QmVZWSLuxAke5uTJSwSjgzkqvqiZcpRDVSYKlvxROKUAwbATIiDN 6rWi7WQOTy1fxqxxpEaLGC+zQgqgDSt8B3ytooYpVx+YKVMnQ4npjf+MQylWhMA9K8SDSBqkYJsF 4EvSSLdkeRzaRl2iZrV8wCFkQ80RNYZeiPmX51ocAXgM2SBzhA2TOzHKNBn3TAofXG3XJrUSQRor cwEyDRq0GpOBcqFU6eDAHGBk8OKtRdoBoR1r2jmkHVj4oEaVUKgIRRRBdtFgsqGmyCyzfcr5ZgwT 2vmGkQPQGKOiizKyDDShehlBCqw6cKkSPqaZRp0c+aBFnXh8IEEZddBB55570MElHlyWJCIYeOiA ZxfJeDIOOaGs2MaLYpAhZQ0J/umiC3Po6cHEN0z0RxeNQOivCwr+saGMbogg4ofg0nrvoxCkISOU Gzw5hQIBs8kmB9j/QOmDAgrEEEWUHfjhR55QzkinlEfYkcecDs44pQRfHlHlDGsoEEWWEdia7IUO M9vKBDROHMkEjZZZ8TMrP1ohCh/yscceFvphoQoWtGmmiiqayYUYYgQ4BBcHInjiiXzyaWQab6wh AZ9+KMFBKDuMCi0tXcsgRIAuXhHTHDS+QQWrAw7pQaNDKPCGgngE6YKJAZqg5J7J3ksgglxIrS/T AKjxxJdQOJj0DG9K2eaVS1Bhl5xvLpkAnH/WYeIbKLShQB5PYJkih2tU4eAWdUSwYBtUk+Jw1ctG wkfWWDfap9YWwx1qBUU8GGAPPoCgRM5A8KmgijWIEeYQUU6wYIcu/3bYwZDu/mGihSKIaQISob5g QBYNAQihDhF2EOKTPpQRxZpEfDGhB1QOOWAMGMoxZwoKRpjHnB2OgODltGRhqxc9cBjmjGlGiWIE VkIJxZgwfPmHA1+A2aCISw5AonMkSsMHHyQ2iMEXTAx5BRN6zhAlFFMiWYETUJQRJAQ9BP/IEJkt q4GKu6UohCoTojqAVs92Hlu0VLoRYpINtBAmkEDMEKYIf57eZZdFOhhmlx1O2IIfPChpi4EQkv9C DVEoAOUNX9gxRxR5wjCxHBNueaSPtuXJxI34t5DE2N6ThjpYoHuRsIACQlGNf5wCGH0wURFKE4hg AAEUz6hCDLiRi/90pEMfOggEEg5QhAU4wQuquMMLTmENeSjDClaIgggcUADcAcAYu9vdZlR0vKco oB4/BGIQf3iPCHTDER/4RC2eYQY6IAIGj+JHPCChDhKEAQM7GMHYVnAPehAOGpH4IjS+qAg7SGYJ shAFO9gRhnDAolHmIAEJ/OGPFzAAHnYJRRgwJQA4KGIFkVAEIKGxBGj8kRORiAQW7iGCaEDiB6Hw xikwUbkw5CAH8NhAEHLRiicQowJIMIAnntEBeyBBGFWwxSmy0YoNuI8dyTAEB1R5hlCwYgmQEMQD MpSUG+JQI4wgwRioQI9YcKAdKeKMznqooRU0gQY/2wAHWqAFJBD/Ixf9EF0gOqmGj9RBADSoYVoi EbbkAUARlPiHGBJxqUD5wxQSMAMYSBcDCYhBHmJQIwUEQIrk9SISI0BAPfawhceFow/GMIYRtmGI OCyiFH04xRU2IAEvGMELBaAGEAbhgj74YQTUYOUMZAOGOWzDfb4oBSgUFoYLCKIOjhgFzHzpy86w 6CkdEVwbzJCKLfxiD66owTJqcAx8IIIQhOhVP6qgjAGU4VGCKKe36HG+5CmiGGzoQhjeIAoxhGId VzjPHKjwjGito0LrAIUXxNAFNvAsKQlIwyCswKdFYAGAk3CBEfrAgX+UQAc5oMYjTvEITKzCD3ld BDXeoJpKPeEK/36hBuV08YY3GMGybyiAHsqmhCZgIQG8nCkOa/qZXshCMi4wAw2YMYompCIVYAiD Ew7gjFp8IB8aaUYSAFCHf/CjDA6oQzjb0gl6uCAK7qBEMdyRCg904wj/cMAJzJaAX8jQAfKAxyv+ YQsvCMKZ3SgDE9YhimEoQxN14AMVKCAIEQjiuWUAmgeK8bJITEIJa+hGKjjbBCUwIwRbGMUkGjcE IZShDEKIQxzAa4MsvMEL28ACM7oRgllIYgtf0EM3NnCFJ6RWCa6IQDh1F1qZjbZFPOmEI1BwJCX5 IB5EeEcz8kEHY9W4CmaAAx3IdVRiEIIYa/BX8joRi2dww8i1Nf/w0orwAgyI4x4q2EIl5NGFE/hB CWRYgwYsgJQISIABr9DDXEQRXRE0xgH/aEEgJNCESRChGCqIKlE6EYkQRGAE21BAHCpqik9kwRSs GMEuEjCcOI8tZiTukImfUgMpHPMP7Xg0FGpQCOIdYxlP4cUY/iAFS9TABIxgRA2yEhVNt8PUj4a0 qRvdjtJshBevlgIvGNEPLRTB1uSwda4vsWtU3NrWSCiE5nJdBFxXj5pQ+MMfYE08RDfb2c9elaKh PW1qV9va18Y2ojujw2x329vfBne4n0Irb3QrLTBCABZAwYjSVIUR35ABKGCBigUUbxnfOEYikMGI RAwiewQYAib/HrGIArCCFEdQwhY0gMiP7CIKSxjFIKpxCicsYhbuGMUsZsGFKIwCwNRY5SnYYRLF AoMCrwiHDBJhKGA0oBoX2ELM9bALAiAg5lYIgSplgImYFjp5begEZN4iCzm8xZ+RaIPPNRSBZ1uk 3G35QQaiMIRWaNob7wiHFMLxDESQKBAVIAcqQNADAZiLDd6hRAy4zg4XLGEPg9DFIFiRBth9pA3x sMIKtjCLxg1iCEOAwQE6MIIlLCESs9gDBpDhA1z4wBva8IYPNJGjd5DAG+fwgTrSYQTYtWEFaUhE BxIRhVlEwAiLOO6dNKSbeWhAAyFw8h4G4IMkUOIckpDEEijh/4E9RCAKHgiBFbiwBdlHwbXMqMc9 olGMTRzpHnvYRaCFC4BdNB3y5h6KBkYQhU2ogxca8dU4aAGKUnTgCmgQ+0i0YY1T0OIcyujCFT7x hFN8SgfFcIUrsDAKTqCDE7dyPSIRwHigBVrwhn74BnywhAuwgjbgAjrghgZYAHIghwoQBnAQhgys AHxgBFAwAjhwBwCYhW2QkQNgBG0Ih3iQhD3YAyLZA0UYilnIHvnKsVogggIYhQxABm4YByDAAu2L AhooAwmohFrwgj5QBWB4hhx7hiJbBAm4BmJogFMAhUE4BUQIhx4pQBfQgCiIgi7UAARAFaZzNnLD vo8YBhc4h/8mbIYDwIedS7Z+4JwKKAex84dDUAcpWIZ3OAclYANwAAMJCAKUKgBKqIUsiALc2wVA Gop7wIU9kIQ2GIU3cAInwAREYAdLcEN8yMBAAIN/+Ac8kJsimABGSBBGCLYiYAIbOIJtgAFhQAJL YAdnCL8SECxQALDhiwIrwAV1OIVEqIZEmIEq8AI3eIQGqERs2IY1GIQs6IMfiII0kIY+IARqWAQd oINgAAVttEY60AFCIAVXaAUZIEdLSIcCS64mOgVVGKw3cIRa4AY/iII9QAbre7qPiARkiAYlsodl ULlJ+4N+YIRAiAM/qARYuAMb0KcXwAM4AS8lGAAioAEPGIT/lLoASrgAP6AwcSA06sMFFCAAIkgF rkMERGgGRMiHEqgGpCkCEBAAMQhGATCBb5ijcigCELnJQziEu+gCPGACHWgFpjFBbkCEGfAFJxAs N3CHSXiDVXI5awmHHDiFZ9CBC6iBomqGRGACNhADAWADArqDT1iDPNCBa0CUN9DGkzADeIiBZmiB OvgBMuiCTwiFV7iCKyAGGSgEjQAFIqCDZPAFXzgFatCHU7BH7NOAWoiDCqiBPzCACsgFBJgExnGH RfBAaqCAPhiCERgASogAJQAFRKi/U8gBlHoGOnABF8iAIRgFK9iFM1yBJIADF7CBOziFVjiFUjiF XPCCRNgA/yQogh7ogW9wgkGgBUzYAXOgAGm4AyYgAyb4BE1IA1wYAS/oABJAhjE4hF7Dh3wYi2Q4 hQZAyWbwBRfwAvwRzMFygmxwghmQQ40QhgNYAFSIF0wQBDmIB0yYA2owA2wghWAIAjpYomcABTcA gw94BTWQBh7IBFHgBzHghUMoggMQhvdkBEQohSl8hFKAh8p7NjMUih8oButcBCgAhFGYgXyYAVJo glGQBCtwhSaoA1MIhhiwUTDogyCgrD7oA5Ygv1YwhUWYgfmShHmIhC8QG9Hgu1ygh1PIzWN8hnEw BkS4hJYsh0NwBAeQBiBIBzJgAxBQgknIAAfwA0wohTvogv8McId4MIVBIIEesMkFEAYZyAYvKAVE oIcGaIBEGIIM4AYnPYV80AEdyIdnuC2oOIBPIgc0GLtyiIddwIUoIIUXWAM4MIU3WIRFwIbT2ytC +IB/2BtxQDxzaIdb8IcJTVQRgoJEKMlmKDJLSoTDFIpNGIRiGAcWoK1aGAQ4KAM3AKyD+4c7EIPv oIYPkAAvWYM1QIRnMMs+WIQ34AAgoAUf4ARO2INoUD0A4IRoIAIS6CBvSId4iAc68FZLaAYYOCZL eAdNQAY18EUgeAc+UAcH3QF18IMLuAMMMAd1wLxpEAN/mANbsARLGIdxiDwfeAdr8YMMoIZr8Atf wAYsKID/JjwFp0jURmiBHsAHKFCFOtAABr0CDhgEUKCGLJCAJ4gTViiAKPCCO5gDCpiDafADK0CG q1wHjaXARH2GU/CEWiiGYHACk4lVZ8uZe1yBXXgHI4iHdzgAS5gEZPiRMoiBf1CDHSADauiCRcCE EigFDngFMWADMjCFdZCAPHgGI8AEDpANDcAF/xPDKeEJSniGYlgFDbiAXDCJHJABjaDAS0iQDoCF LiCDAAgAILDMV2ADcxDbLHgAHlCDABiCTYAFECiCDSCHp9g6FXWBmIuALRiCbPgUSwKFKWjCZMCE qbwCSyiCb+iBdZiCIfCDeBCDbGCCAsCrLMAGVngDamAF/1fIEibwqlI4g12IgEzogHgpAi14gkoS pSGoSJQSrEcY2mYDUQBYAVzwBRmYOE2EgU8Y2SHgBBxghiYYASX4m1KwlBcQgFvoAwUggx4ogkZo hDFw1WIogC0gPU6Yh6TYhVKQwz/IxB9wBBVtBV/oAGHAB3Zhk3BQBrkME1hQAwfYAQdwgAAAWzJQ hmFwhQAQABBABVRAgqMB4EQIB3YwghL4A3wAAhSQhM/NgUf4FEzghnyAg1U4SrX7hG6QBjUILivA AmyggjuoBC8Qgt0bhQhIhV9gBhoYBHDAAw6ghWjABXEYgQA4glcAgzyAgDDIAlagg1zYhj7Y0NCV LWdzOv/EVAUnCEZfGAIvUIdt0INNeAcdmIZcyAdiwAM2KDsBMIYcuAEOYIMe2IBWQAR9wIILGITt c4f+Ewfc0YBuMMESkAJngAJgyAAv8IIcuAB9IIdWE4bwWgdqkAYHUAJSIAXBNYRPYAUqeIBPYIJ/ WAMekJV+yAduYA126NPAQwJGsAQvmAUUyIBcEEwnwKDAHCz2HAQaWIMYeIJWgI0sYAYNoIQncIQ0 +IFtgINiKAYicIQs+AFMeIImiAAbODh5coJTqKsiiiwZzodxANRHIKzpRbSixb4fQMZseIQcAIVt 6OaM0rxsOIUZQAQwwAMv5YCyAwEmsIUrCId88IRKPIX/PqCFtj0kuBUKcVAHdSACbbAEdtsIKNA+ dsAPdugHeyAHFuAkfUgBVpiCZMgBCjCEa2ACAWACYHgCAyCHkg4HIGCH3QwBVmhaS9CGdzDAaVAE SfCARZiGyYHn+uNaGUYETOiDZPCEcSgBUDAFfpYBX8ACLNiEAqCDYkgur7arLdgFIRCCbpiGyBqs T2lrX9CBKlAjVXgEeMiFEtCHbeC20CK3JQignsoCW2iFlmuFieNZ0ylhbsAAFxAEXKCFd/AGeJBs dpDscAiHGSjscNBNPnCroXCEVmgFG7WFbuiGNWiFILgCG82DVCiDa9AHfQiDXFAHH/ABN6sFOICD N8jm/2LgAyLIvGltPD64lDD400tJhKvYiCkQwSXovz0ovCVgYRRYgjbYgjZAgUhAAeKLOQ8Q0WLI gmJQolaYgjdwg4A8TTqAA31wg5zowkmYhSTglyZwgYFCvOPyOHTYAxRAASywPim4iP8G8AAX8AEn 8AI38ANH8ARXcAC3Bm9w8AeH8AiXcAi3PMt7cAuf8Ar3Bg1/cGOg8A0HcRBfcAG3BqHmhWNA8RRX 8RVn8RZ38ReH8RiX8Rmn8Rq38RvH8RxncV64iGMQtx8H8iAX8hK7iEsb8iNH8iQnsViQgjGYglhw glhwiDEYCePxcctIgTTYhRCYBy5PAy/fhlswkafAB/8p6AAYsAQpgIF1aAcjPwBeYAUul/N5+PIu 7/I9gYEaSoMsqIaKOAmTOAkeTYk+yIU8ENZPwISTCHRFz4USMYJd6iYlkIYQmL5yGo7D+6M9CAFZ yA2lS54R04wPEfWt2IqMMLVYYIB2iIV2mABeoIJ2KJ4i/4zOTqTAE4t0oCxs6FFrxAQwMIQAAATL 7INqkJEJSIOxSYM0CBu3iqtYXYZE71FCb41cKAXVwAYyiAlESQnKWo0/YAQvQAt8lPQjiIA88bkz qoPzEYF1L7N1twBZGIWe8/S0CAVs64wrvym3ioBtiIo/UHRF71Ft74NrwIQAIPQ+oIYeTQYTUQXh SgD/aWiHJB2KUSiARv8N1Rj01VgJB7Msgy+FXFANbTfTZKgGRhgEDTh2njCESTgCaWA4nzs8aJiL HaiEMJgCN0iGFFgEVqgDqJHEpJt3oegla8sZbXBzjuCZNPACWekAk3BWRKEGmXCJXQeFAPgEl7DM lvAFjVgEDZEFGJB4oYiCC3iDxvx4bQd51WCNRMiGahADZx10lMh4KYCCN8CClH+rSk+KNmgDSFj3 FEiEUwgHJ0gEJ2iFRNCbiTsCqCm6oP8IVdkIgTCIyZ98WVmIbyCmYmKAVS+Ne/+MobACIxgJSxB2 tJcJRGkfvap6QGCNlAAFTMBNKXAFDekEckqKfc8B/4v9A9ykdpRKdF/AB0orh0RoiWSg9kRQuQ5w CijwAiygqryPqi1YAhU4AUFQhylUhVuQgXDwhRwAhoSphlBwglugBkcQBGTQgC0I+kPTjI3Qoc3Y B1iXAhOginfrgKjojKPXCBfhCS8wkQ4ECGp9cg0EZbDPm1wKF5rDJFChlEUA0hxgpKETgIwaAUS6 JWujxjRYYBwoafLAn5JSGJkshwZTByk1GH0zyeiPkW0XrIDMmCBSz41tZrWRc+IEP1iwutAzICCU Dl/XcuQodYOelBnhVGH4cUJEiAizgpLNOOUk2rRq0+7Tpu1YWgUaey0qeeoNqD4P+/QBtSgXJoUF A//48jViRKQvAHo5StBJA7hNo6J8zNhRFsaNozIM2pZCm6VY2tRpe6fOBxFvbrWFsvaOzzu3p0m8 88YuRCRXaYL+JBtCySijcuK5McemGQwYTswZSwbqB4AHqoCEkufPnzVlnKINEyTCQqR5vcqCfLF2 rYlyJmKhYR8rVo0xB465XZaWlZ2MbbyUxPSmICiCBQYYNXkZIYM860SyQi+98GRFg2+c4ohGISSQ kR23hNCTFcioI8M1xSBSBTGElEgMMRCgiOIGG7TgYoorVvEMHfD4cA80vAEFkh51WBECP5q4kAI1 yZRiiT+xhMMNN+ZwcEoEGfWhijxUWHPIIfQoUwn/Jq3BYo4DHsxDnkYcoFXEJZeguWaaB5iwjhSx nBHLLfuMwYAxB7T1VlwarTACFQdUQw1gBBG610GLgCJFOaxQIdcsrMjAgSynYGJKLIu4sqNlHuUH khs5BEOEEKlsoMYrZBxBihr+9HBLAdIIUMMEscBCyiepHrEGHM+8Aw8QbvAEUm8aRWJFHZ9QYIwY 5uggWDaFlOMABn2Ycwg+UDhBzRCDmCOKN8ZYg90ZCgzyiC+hhBFKAGlEsCF55p0371r0aWMfWvhV +MYB31QDCjXU+FJKMsk4NAU1nySjwynflFPDAxv1wgojNUgBxTftpBPPCsZ61PFGkYxwAREeFLOG /w2GOLADGWf0cEAhXtRwgD+34PPNIaKIYk4y/0ggQTFE6OMFKzpqNIss0oRCQQkNAGNODr4kQ1Ur p5zCQTqVZIJBAKJ0sTMsJIDyyAzmnHHKGaD40YcvU1CxtB9paEDeWfTafZK9cKEll59pbFMSI9PE 44M6hRNxOB1VVJH44oqbQUctxfjgQy3XjMMCC86MM8MeIGcYQmYbWbENavqswQQZeXAgTzk92CfD zCAwUNIh5ZTjjyjrvFBGLXEQsQVZxVoxSgSwiLLDzuaA0UAzrbBTyiAYaLKDOfJQEEp18oTrSSml XPOINRTIY4wxt3iiwyPGnGGNPNH8gEVZdZu0AP/99ddPeyxUUBELPVR0MEZN5lOf+4QOAF8QBy7Y QQ5y2GMZ+XiGNxDxDG3AowraIJEwuuAPaahBCAMwgzP+gDnM2aMfmNPApy7zqZ7ogVSE+McOunAI f3hjGagI4AF6YIKSgAB7h7DGDgSQhyYUAA6cIEsvgDKLNChBATs4QziyQYWutewMsBADBWBxBnVR gyT4OAASvoGKf7yACrooRUxCIQpVpAtd6JpCdlaggbkFRV70WoBJYlGO96BhDGjgAEkEyKd8FdAy uOADCb94AHxUIBAoAgIfCBEIEOxjF4JQg4zokI5wDAMZB2ABHNrgMVmADCQriEIxzBADNThAGsr/ 4IcoeCHGb5hAWqi4YTnMAQtNiMMdQUxFEzqhmKAkEQBW2MIIlPGtUNziEQ1IRwpg8bb1caMPrzAE OFBxiZLgsV/9OsY30KCLZLBDFLC4Bizc0BkFWAMWPKjDNuAFEjPdrZ72wtdJ+NYTHNQDDjTYBDvC AQ8I2KID9qhAFSRADGGAwBxfWZkAmMCEDaxIGIGAAMc0Ygd6yDMoW+iGGvhxBGoAQhmisIY2ONAD VBzgED1IRLoCQAJlWEAO5tiBIdbQUZDIAihWmAQONDENa+hjCG7gAQYyMQ1jxIID/2CAKmKxgCJQ 9RJIIEeaqFoEGJTAF/8whCrGcQZRnIEdw4CG/x2GcQpYeKMAu+kJPetpt7zdZ4WmrMcePKCBPJgh FWsQRhGEoYNrBKICIJDHCSwgjVTtIIZseCo4AluGUfiJo+SJxC9EsANH+KEE09jZIWYAF1SA4BtO kEE5TiqPTLiga0woA3l6Mws9QOMEJBjGZjBgjNaUAAz/UEAf8iCBYOADCcIQRgUsSo4KIKEkBojB FXwhA3D84xTGMCkscLOEAsBCEEvAAqc0kqeT2KO8+LDHedH7xW9I4RZUSIT+wJGSktzzPmRagQfK 4AEzUEICLbiCMKpgi0AUoaEikMUPuLGIYWBAHubIggj4gYduMGMjX6AHZmLrgC7AIgvUyAEmqP9n DWPM7BAmOMUjXtEFa4jhBkMwhzmYQAnyFDNp0BAEMiLRizpgbwr/mMOHD1AEVMiAEGZgUgk8EQZu 5EIfxeBGFQJRkiKgZBD/cIInrKHGEWxhG8g4QR2UEN6MGAIt+DgzmtFsEikc4D0TQEMNqCAfQert JPoizxdSUQYlKOEJ3SAGCxQHWH/sQATRIIUX+hAKcYhAsw6ocE++4JFCgmQWEohhLlZRCk/cYAfy CEciCnEIGPiiASUwhz+WtYhvcWJYSIxEJ9xlAUHsIRJpmEYoYvGKZPhiEby4BB6RUAEDlOAZAlZc VPoQDAMIe8p9ScYLXpALLYtCEG0IgQjq4Ij/MQNAfnKd1zIGmC8yGXAAey5DC46rOAgUoQfm4Id3 veCEHLDiKHIYS1kYEI178JsT/b6HvznBCSEcQRPe4EM6cqGOnSmDBA6AJQlykQ5dsvUdyuhCMKzQ 70gAnOP+7ikANNALC0RDFnLAABR1YYhP5KLXWdjAIgbxhBjUoB9BqEQurnENHTQCH+QgBjtyUYIY 2AATjyjFyk9hjTNMQxByqKkpolSebx9ACss4BkvQ4E36uqXOJmFFPcIu9rGHnQCUyEM68iCDDTyj FnTIByoEwA9410McJuWHEpYQdhzwXRGK4HvYoWFZMs1CDpqgxyN0IAZRLF4eJBhXIq4wh3U4/5gC 7DiFPPAABzIlMRIagERN5XADa6iCGphwalcfEYZHbMATpwiHDtZgBmEstwIVIMYzwFCNcJxiA3nw BTDY+A8O6OAWu/WFHsShiR8MAa4nYYRbULqa1fSLHqFwAgOkECf4cP1e9yllTyKRCmZsIQakiIEW yBEDHSw3EMLAAwi+YodoBOAI5AbACgZPpjJ8rUrVyMVYicE6bMA/5EErSIANLF4osMOpCUA3cJ7n 7YIKRIM4DIK66AAHlEIfKMA/8Bo3+AI2xADavQE2gMI2DEIp5AIQlIAXaMA2pMMVXAEovIEO3IEa DELBYAImaNkpYMAw1MGmgMR4pYUiKVJJfP8DXHwDDtVZuA2SnZWFBxDCKHzBCGyA+31DPxBCHjhD SVTABxCDDTRaF9gAtwVFG3jK/aWBGNxCCeSAGMjDCwSDnolBNbDDzFmPOVABO1CAAJQBpUlMJGxD L3CCHGyHAqxCqKSgFxiCKZygH/jCKbDDFcTAB3xAHAADMLzBBQCGMZxCDJbAXzDAJwxMLlDDKgyB FxgDLODCD17AW5UJ1dFLfRFST0wCIdDAF/yCKxQCPizDFzWCGZjBF+FDINRCKlzahnnAH0YaA1QG mRRFF1SD9YiPGFzBEwQBB7xCEDxBIOBBKJhDKGDCJ5hDF0jAMnKEBgxBL4TAMJBAPOAAFwz/wsAA zBz0QRZgQh/8xYDgI164wQe0QgxuQAxsQAr6Qg4wQA7wGkGAgheEwBagACe8AjYUgDNmhB3Folo0 odeVBH6EFwGkQir8wiiMQh8kwhssghTYQzDoQ5QFgiN1QxMYQmPtFJ41o0bgQDTgAi6cwzn4QBMQ QTEQA/J4wSCIgjyEwjpcQRlQwis0AyIo5T9QnhgAwSooQyjswBH8QvBEwgNgQRwoQR1Ig49swTwM wSv8AzZgQsFMzeV5wiMMgQcMgVQUAGcAwRW0CDAYTC58gCGoyhGIZR2EpVgKQRMQwJjFFUamxSza mY5ZBhx4AADk1y9kQD+YBD6UyBOUVyEI/wEAyIEE8IMabNv9ZcQXVAMRTA4dUAInNIEH0IASqIF3 IIUIyMEoaJbjvcAdlMEaHEEcOMIadINviYIy1AEk7IEy7NIOCEJGCAEhVMHjFMMSAMAsRIA0sAIW SAMNgE4kRIIHCIEElAEpfIAE2IJA5kFC+IIxYEMwDOQVlIAxYMIVkMIF6IEViFJG6EE3gOcIREAE EMAI4NtGIGZinoRG3kckQIIxuUAxgCRIEoKDCgFJNIIXzMAXIQExNAEAhMClGcJNHcEwkckXOAEm AAEQGEEtMAMNEEA39ECBfcVXyEIEvIEmOMAQsMIcSIARgAczSMMTMAED1MEJTEMmzMMuvP9hCMjB DmhBD2xACDQBDVACpREAbxLAKEzCKABPRvyClmrlF0wCARCAB9TBFiRACEyClf5CJ0wCJXRDNwiB NHzAFZhCGlgpAAhTWQzhgOKNuOUTR7TBBaADoAIqEbgd45AIijhSiaxBKggBisAfHmwAht6fEziB LzjEG+QBhUkAVbWDIAjCCUSCTcGYIOiBNJBCGYyACGTEJMTAHBiCUfCAMjydJniHCGhCORRBBXTD AAiBF5ShsczCLIxCazZBHDSBElBCKmQAf/KnBkxCAYCksW6Dk35BJ3QCDUxCnY5mRuBpnpZEgeZL fnzBIFgBJ+zB5LwDuv6BFLxDPPABPMD/gzYQAS4E6iERQRxQwmmiAyeAH1kkQj5cYxDQgT+VgRmg CBMcQR0ARQGUgik4gBoYgSkcgQT8gAVYAAAQgAT8wyJggR5IwiBMgyxAQh04AClcAYqswZNuQgT4 KnkU0AqswHZup0aco7bCYrfqqfftjY6FwAi4QxRMQhb8hRGEwwGwQzrYhz0cAzrEgzoswRKcgzLw wCYMQQfIwB/IAAJYwSzELNdGwk8kgBOshCXAw7yiAy78ZC2YgYlk7FcdgSEYwj/ggQR0Aw3UQZnS ADFIABP8A9/6TBnEgIOWQSp0gw9EQaAOgxsogOIq7hEwrgI07hFE7uNO7uJWruUuLuRK/y7kTu7m dm7lBtLNemvXhe7WfRsedVM9GaEioe5JnNkRGqFlcpNawC7p1q7t1sue3q7u7i7v9q7v4uxG/q7w Di/xFm9aNCE+Ga/yLi/z1q69rAQjjEE7/IH0/kF8MALtHuEy7NDxgpMSYl0N1EAhKCEjlO8YnC8U nC/1ru8Y/EE78MIf/AEvzO/8yq/8vi/1toP07q/+Vq/+Tm/+sq/+um/77i8Bx2/1tu8Ar2/8xi/+ Tm8CD7ABn+8AV7ADX/AFK3ABS/AAa11i0oc3cMJPFFAk+IEVXABMfIM9pCAjyEBfkAH3fsMy+KIM pMAfhEMfZAAWjECiZVoBXEAWKEEazP+CBojDr87CFvyAEmzDNuxCJCBxG2xBG1iBJESxI1zxEv+A BjiCBvyAA4yAElyxGDuCEsxDG5zxUAArUTzxNjzAFb9izWqrBdBsHGtEBAxouHkDDvArAIjDD0wC FjiBWnSAL5ABPawGSsFD4VCQD+jkOdCCEZxCMvTBJ8QBKUjDFswCbmQEApjxFuiBLzyCfwzxd2HB FpzyQ14AJPoCKDiChExAA5DBFEhIRRTMI5zCBbSBJGxBFAwCKAyBO1zpKIBCKA8BgNbxdv7IPIiD BkRBNOzCLkRDFERzGkTBHqTBLiRBBpTcHiQRH5PJLgwoCO9xT8zDD0TBG8hAZf4BCUT/H2zQwzL0 AzmwQGFtgARswBVIwBPAgRnkQzNInA8s7Sl8AgEMQnhFwi4AwFCg8yM8wjaMwiY4wRuswCxwQRVH Aa8lwxAMgSVYAi94gzLQgjrQQmi8xhRkwyJEQhssQRsMwimUgiNUsSt4QSIMwhawbPiFwCZogBVw gQfogQc0wTm4wxYMwB4sgSTMAieEgNZywixQwjnsgbAmAQ0MgAdwAi5EwyaMwDzgNADc8Qdrgx7z MQaMQBQMQSEwgjVAgbciAjcAwTow1yX0AAjE3dfsAD+wwWOtATCUACJcgzuU5QjEAzK87EakgSsM hTugAApMxiCwdUUMwSigQKCiQzT4/8Ag6EMrzAAixEIzNIIJzQAtLIJpxAM6LMEXfIEjmIQbjEJB 12d9loUsaEAIDCI67AEXCBwRJMEWSAJjb4E7hAARUMImFEAx1EIt6AMTXwAcnEMq0EATADdwD4A7 3DZj78EuZDW3dQJYY2Qek7PEIIMejIA3WMJJ9EM+pMMq6AAT7EMRuFRNxIIYaEI8JIEpsAEpSEAQ hDIoPAMl8GwUuEM07IFd7cIsSMIo7LIk6AEmGMM7oJQ3+MAebMEXtEEEFEMxPIJJIEE7fIPrHoMR cEMtREFq3wM6vENHWwK6ngOgzisC8PEKpIEVLIGwRgEC7MImLG0wIEIYNIAGeoEfUP+DE8xAPtxC NbRCPnCDCzxDPoRDFSTCM0BAK2RDKzSAJ3DDM1SCOsSDTuLCLqBAFMwRKWlEOIf1WG/ECiDDCKCD OpRACVSDU6YDLXjBIjCCPcDAe4PAAfDCNFCBP6jDMHTBU+VBDJxCIjjBMxCBI0SBJEiC2RaSBqgD OuxCFHCCC2ySNsgAvjACO2CBC9BBKwzCBxQWOSABPhzCBCDBQVXAAZSACwQDHSRBATQASxyAJeRC NfRBBCwBCkjCHuyrRsgCpZuMEZTAKTSAwA6Jk/kBAVwAKwxCBqSCBwxAHRQDKZjCJyzCNVxKHNRC M6dCFKQCHJwgD4zANSACH/DBIJD/6CBUAnIXgwdYQRTAWnfH4jiDXwjQAjr4QTOwQD/0Az5YQik4 wXxVQDv0gEsdwDRQQDmcwS6MQABcQSzkgS2Uwim0wjO4AFEm+GQsyEbkpDtIgjsMQdWQTT74+7/b gzPEwBqUQZvagBb0iz20A/dW3QX4QBKsAQQ0wgHYAwuQQz80Azw8QjY8Qi5vwSgsQSToNC74gRtM chAYezacQg6cQpN5QRMMwDZ40ABkpzSYgXOcuw68QYH4RRAEQQxQwgi0Qg7EAARsACEMgBfUQhK4 AhFIkJGDggYQAQF88i78AB6LNXhzhA9kAB08giqcQtEOQiLMcA34HBKs1CF89DRY/0Ii8EEAdAEY 3METrEEnlsIQbAEcDEIBPOQzg4Rlo8AsoAAWGB2lPgM3sNkBCIM9FAETsIEDkAH8uQqVHYIY5bkA sAEeKAEMGJcUlIAl4EM+eAI7DEwp7PoWcAEy+QIfkAA3oFgDJLpLO0ErTCqvXAETxOckZIApGEMM YMM1PEMJfsI15AUoBEEtSMAAzIMxyIAUtIAMvEEGlIEewAHb5wBAZGswaAiwfE6cYNqE60BDhw8h RjymzRuOFQAAtImHSwM3FiycLaqWCIYUe4wCtWC0ToCyLqymvZOHh0m3MjQyECESBNG4Yi4oIWgT JYQijAAi4YqyZEkbRzlUZbvF7v8RIhkHhCFpkWkRGwEgGpYDYaLIIbLlenzrw4bCP2otAjWT8a1f vkq+Sjxy8qjAlihuQOVqwE4du1PhTj3L1WeClFbEZFx5xYDDj19KmLwxk4cOtUp9PuUCBWqRDm4x YiS6w4AKPVUvrsSBIIPkHymgNDxrxi7HYkyJIgYXPrHiRQCcvBTTIePYn29/lh34BqMMsyjFrsH6 94HJFVKkbHb7xK0YK1YahlAbVCCDnxGcxPUyvkJDFCLFPLhgl2hGuP4lSpEBiQouAaGcQw5ZB49E 1pGnCzF68IcJCuQR4IwzYHmgCzZ6aGGfCpD4I5dr8skHkRlmoGaSKKZpcRpaaAn/w5NTGhjnmje+ OaCFViKj4AV2XnDgBwbAyKOMa555g7RrSOOGjldiuAIcY8Q4ghUx8GDjDnAgyKehCbYxA5NTHinz FF/eEU7Nh5ahyCKMQihmm0D6MaCVFsiJoZsmPPAgA0yoyYGCQfoAJYtU6iBgkA+eYUUfX3Io4Joq atlkkgKw4GSXJYwDYAX8uLABmBycqKaUU0ox4pYOskLlkAWg0AWZSjSB5QUKctlAgCsc6WKXTHw5 xRh1vOihhyIOQGKDcEphJ5xqVKkmn3RGyAUYTwYrIZdwsjkFkUZyPKACfC7poR0YjPihDkc+ccuM RUB5Jhh436iFjkVskYCUOgSZ/2QRTChoZR1/WpChAodkQIQbMh/xJRd1tFlT4n3cNG6XYIgI5IA/ hLElFRom8WCLSUDxJY44YOEAi1GY6caUXDB55pExcyHUCz12yWAbLyZBB5ejMNoiEkruRegWX5zI oY9FEBEGn7K+MQGZeIB4uIsuXmGiFAp0YYINNTaJYpdKTqFFClRAQOWAQBLBZBBvm0mERh+QOYXM UjDBpAGE8rGnoQoa6ecSVMo5oIY6IMGlDzAMWQMbU/R5441rguFjkUViyAMcNgBBZhpzlPHngHIu waoRKGqo4cRsHskBk0f2k3hN4t5cAZ1i+Gglhn6k8GAQTIx0Z5RJtqFmDWlG2P8GkCky70OHYPrI gt4+Yk6ulj5GkAS+To5qw4oosHkGkWbGQfGZcfp4gpwCeygnAE2SyWUafbBhwxACvKDg3y3ZcIGT eLKRjjAcqAgLaIHcXJGMfJyiGnqhRTzC8Ai7PYMO+WiFJ1hwAHwsAx/kOAAqLlGOb/RgGDiIhgsY cAYJ1AIwkmvhGz6RhyusQwxYEAcC5OCPQ6DhEAUUV0P6kQhEIMYXyfBE7GQnnDZ54x6eWsEwauEF TPiCEYMoRi088YxtNGEUo5BEFOTAjy6YQQjY+EQf9BEEIyiJNKTRwTOwAaBibGEJm5AF8jAyCxQU 4BHZwIsE83GNdLQCAgswlgn/QHCBHwQACLDAwz+UEDIsCAILgLEBG5QQAQ1kIAS0QCQIi3AFu3kC EfQgVSuGMIJglakVz3hUNegRHSgkqwIw+EcXUPEHXOgBFxkgxStsQIgPkMIIi8DG0mxghm4cgQEv MMUINLALIBygD2LQwgLEhYRvaCER4guCDqrgiT4AJ4nBoZg36rGCFdgBisVYxTKW4QJ5NiEVBbBn FLYBizN0gQJA+MAagoENbKyCG9xIByj6IBoghAIU3uADLtCBjmhYAWgAQMEgSlECu4XDF+PgRgkw 0YwKFMFAUhiCIBwQADAwQQGYAAU2RMEPfmThAg8AhwPAhosQqKMGYkGFMMaA/wl2PAMIeMFENVKZ jmyUgho6UA8dnjGVQvyNHKiQAhIOwI5oTOIcfbjDJ1zxBkCAwQzU+EAMymCKbQxCBrHggBimUB9W HGAC/kDFAmoQiEIwohQNqMYbMkAHbriBGuQsJ0RoZ5xheGEEfTCJEoIRhGc8wRa3gAETyKAEQ7BB DIYAAx7woKDuSMAMihkNKF6QjneoI6IS3QPQfjEKLyyCHaV4gytGMYh8hOMq6yMpCE6hDDWwwgdH YMJxBXAN/c2QDIYIhRjUEI8zCKBDxKhAP8jBgmaEYxAaGIGkBqHKPgDjFNnIxiI0EId85IAbUsAH 4GBgAHz8IQxXU8M08jCHPv9cQweLMEJM+aEEV8iCFTD4hBqcAATvIuMPB1jHHAzgtGM8g8J08IML cnGKHJzCsId1yBLfBIBoeIMg7LAEPfSgDj4EAQIwuEMAUsqGLiwiGRwQAAXYQIZXsOEVd1jDNcZR zFf0AXsI2IPPjNI9SjyjGMHYhp+S4Ad6eKIGByAHEoqAh3KsQxQOyMA0zmCITEQuGDo+QgCUIAtH BCANgwgdE2LgDHzM2R7WCEc+irGLSVzKX2dC1Zh8QYdx2K0BwNAYsg4ADgocYQisIEMeGLAzRxTA EW8YxBtmmwVWbGAd67jAPL47DSl8AxVFQAI5YsGNajxjF3rQm9007AQPQ+T/nLXDxYto4Q18yAAL vIxGMcowgCPUAadsOEMy4pcMTOggF594xT/yIIFnLEIBWfDFENzR2mhEolNWGAKJOJyIPgyhZFex MpYj5A8yKIMNKbjaIHAshg3JGBarcAAF9gWItGlBGA3Bhz20scAw5GIbF8iAJPiIqoYtjcIaVsUT 1oAJJvhDDEbAAC1coIlPdM0IWMA0NfrghSyAYhAheMMGxAADf2jCASdQwylQYYIesDgMviAlgEDx iFOdqcOzTixGNDASdvjiG/hQzyBK4IN6JGEATVBCHdRgCF9MvQRieMEU1MBZGDwBBix4Rnj1sIWw WwEBFQ1BLkzSj48Ugw7N/3BCKXLwXmyibR2VUMPVyFCJzYqBAvOGBQUowANkKEMaAjhEqbGCVUZw mBtC4IYzvmEMFLjjDafARDJK4YtHyGsVTjiFEyAwiEs6QBaCUIM0foCNWzDBC1hA6C6sII5U0DMD VED5I4xRhxMMow4aUAMgbECKGJxqHIjYhscxUYo+NEzWs/5wxYDui2o4IRug4AU+ypYCWqAjEhGg AQ2OcPcXqEIA43+EAk6RNhgEAgYyaEUtakGJKERBEr3gNtAicArDlaADjBgFFjwhHxKhGk6BHISh EVogQtbhVh7kFbqADI7AAXZADRTgFWBhCFJAARTgBcCh1AIhKw5ABmagRP8orBb6JhjcwQpGIAda x24eYQquAREIIhcIiQM+4Qge4AciAAGw4AHu4A4A4QkgYA0oIRVSgRm2YBRSIQ7A4Aq6oA6IrQ40 QRqO4A444AmCYBAegBqqIByUZIpcUP+cryFqzThwQW9aIRFEw6Gm4Q34QB3eYRp0oAx0ZUPmQBXY 4BbCzB9AgBzYLx9KYRsmrQD0YBYkKhKSDCPSABQ2BhNkoANqIBkujaCuKDoMMBD+AQR04Q3UIA6y IA704RO6ABMuhxUUwA2Y4A5iQAIqIEfwgQUEyxf8KxmgAB80KBPcQRIiIBd84VQ2Lx+eIR2SoQEW gQDMwI9O4QdTkQykwQv/IKAbZEEWCsAKJmEERiAD3iAH1qAbKMEQ0kAc0GOlgOER0oEGmGEXAgMR nkEVNI8FUcUXxrAhfq4TfqAEEuEes8EVLkAd4mEPcIEPTiEdcgcCmAAPNuto+gDH2OAKYoAbdABT hqAAosADjmwP5KOi0gAbtOAAeOcP/kALKMEU3iYXjMBLGuIbYsAWjmsQpPAI/mEHdsAGXmG40oAJ xMAWPsARviG7/KwE3mAEBgEJ8MES5MYLJGEWcqu8JugZPOERVIFMssELmKEJuiEGIMAW3MAVfuAI h4AgaqEYokADUsEFvMDkPqE64iAVW6EVriALIiAL8gACTmHobC4fPIEF/6euFJpvDEHMDDmMAE9h CLAA6dLBF2jBB95h6PJhpWBBDK4BEF6ADdbhCp7gFHar+rIACxwBC9BhD0LADipKxN4hDgxAg+iq wT6AErDxFLzgGligH/rBHlrhCSANtNjgH06Ba64ABIaADJjAFmyhGgygHyzBMKqhAbAgDZoBmzaG HdLBBzjBZ9ShMMpEFVSBHcbBE0pgHJ4h84AhGzBBAQYBDtagDAggA6JgFLbAAyjBHXaBCCjhArZh FBBAD8rAFiCgDPzgAYxA83whDAxj6rJIfOzGj0AuHg+gDDHiB9ihAc7kEZIBFCSHGmKiBDzvGWKg XQqSJphACEtEAMMhEf+MgQ+mQR2iYAvKLjQBIA2ogR1ogQQsQRtkVBtiwRLeIR6GIAPGxhLsQe1Y IAbW4A00wBGSARjYIBmoIQ6OoBskIBDIgRzsYRmGLgcMExfewRu8wRKkwBIsYRmMQRKWgBOi4Rzi 4dKMwA2KKaFKIR+oARN4gsLyYRx4cWOcQBBHrUeb4Q2wQANcIRcsARS2QR+SoYimTtmWkg5KYBWK CRR8IB7iAR2GAUF/DgB6AQjIhNAaoFs8jx3YAR6es1H5oBaCQVTf4UpjolSxFDHggR0GQRxUFCMc IRFaoRk2LBdyAR6qQQRR5Bo2wQNwQR28QUb/oBkoLD9TYQCUoBtSwQz/nkAdDUAKtOGB4kEdcqFT t6XKPuwAjGEFJKEN7oETlmALOOEoUWAWtkASJGELkoAG6lMPRuAChqAWnsEICGIRpqoQpEAGoOAb xsQAPuIZrqESKiFg4U8io4BP9mALuOBE9yDb9sAKJOEHbJEvZZQGKEEPmIEAhOADykAC3GARTGER 3MALFCAFvMANziMKBCECHIEVjED7VoEW3MBk3aBmQXYQTAEDonFnd7ZlOeAPDMAAWoAF2LIRtCBo G6ERmmH9DEAGYCARZEAb2IEiSrVUYWEaSGAavGFqZdQSwiARpEAKDKADpMAjpaADLOEYHGIKIgEF 9iAafAYXcAELdiEC3bbACqxgFL5nC8x1C84VBfaMEpKAErDAD4qhCfxgPOMPUzRAAyIgCtwhCfv2 HlCAE+4BTCXhC2YBTFEAHe7hHiLhBxCUYrSBF46hBvahBo7hdFf3G/ahdVeXdU93GVT3GL5hdV83 dle3dmN3GXT3d0+3dnl3d0+3EIj3d30XeHUXnpT3GJI3eXU3ExRBEaBBnaaXenEgexUBBxSBKSKB E8B3D8BxGC5gGEbAfMn3HIYBfc9BbnFBfYfhHH5gEzRgGDQAF+LjW2UhGqIBotwXF3ZhFzCgeQlY d3lBGwICADs= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/portal_imgs/search_result.gif R0lGODdhOwBQAPeGACBBQQCUizmsnLTm3t7u5giclPb29v///73VzbTe1SCknIPFxYvVzYvNxc3m 1bTVzRiknIvNzc3ezdXezXvNxb20pMXm3jGspHvNzXPFxRhSUimknJze1RicnBCLg+b//5zV1TGk nMXezVq9tL29rBB7e9Xe1RCLixiDe73ezZTV1dXu7ub29lq9vdX29hhzc83e1b20rCmkpFq0rBCU lJTNxRCDg+bu1cXu7lK0rBhqahCUi7S0pFK0tIPNzVKsrCCkpEG0rO7u3r3m5kGsrN7u7hiDg7Tm 5giLi8XVzebmzfb25vb23v/25mK9vd7exe7u1c3u7tXVxcXNvTmspBh7e9XVvcXFtO7u7t7ezVK9 tNXVzcW9rKzVxf/23s3FtM3FvQiUlACUlObezebexaze3t729u7mzUq0tMW9tBiLi+bm1dXNvc3N vd7VxaTe3sXFvdXNxebe1d7m1b29tBCclM3m3t7VzRCcnAicnBCUnNXm1f//9vb///b2/9XFvfbu 1fbu3v/u3u7//+7m1RiLgwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAAOwBQAAAI/gAPCBxI sKDBgwgTKlzIsKHDhxAjSkxoAEvFiRgzatzIsaPHjyBDihxJ8uEgDGYOvMkQpeAbDgMHMehBBA0F FgJZYMAZ0kyYIwd6BJAxiGCPIAKjyLjg402ECx1wHIgSRmpPPEMOaAlCxQnBEWgODFLQos/APheI HFhRp+XVrD1aRKlTZiDYAwzwfCj4wcXatiLNYA3a40AECDzvogmLkK3biX4QCoZb+EAQxncveG0M +C1hgWY6gDhwN0jlg445rlhB0EUdygM51DHjJCyGDmYJDmqZeqMTBbkPqJj9eeDWHmFdZyiIRsbf xxmj4OkxYIiPPMsPLCb4AYgYxm/C/qB5g6MMmgJ1qUI/wKe9+/fw3x+wkGPDBgE12h9YsIC9/gQ/ NDCQBTOEIEMII9ghUBEzEOBfe4FEKOGEFFIoiCBCQBGIFxJeKCEgHxJCCIiCQLEGIR9GCGKFLLbo YotssOHGGFJ8wcYYbEhxo4xuxNjGGCi+KOSQQwoxx5F7zJGkkkoKQeSTUE4oxBo3rGHlHFZe6WSU XHbp5Ysefinmk0JIYMIchEjhxox33OFGFmu64WYcbsThZpx4rnlHkECKWeaZhLQRQxpfkJAGD2CA YeMXjLbxBRg65ihFG2zQKYUUfAb5ZZhrTHHFF2mkEQMbWaj5Jo9KiEhIqqq2iqKm/mMGIoQIIkhg 4xVXsMHoFYTiuiihveb6aRtXuBFIFrCOKcgYzHrRxLPQNuGFs9JG6+y00gbCRKwVEvJmj25I0Sac cd5xaZzimhvnGhOmym0ghMTBRRq5OkopG2DoWmmOMsbRRrhx6DjGhCe+G0incKSRRaXf8rjGGVC0 GggUGm5IYbJ+iuCACW2A4Si++H7xLxtXtGFyHISMgSyHFI6xZayE8BhHwHfQOXPAUlj6ZhwyXsoz zwMH0ie33j56L794jjHjmkrLSW7TQRNScaxGTrBFjmtWyqzKQIq4opAjviuEAw7swQalPeYbY74i 9snE29qyODTM+faoYxxWhBvj/sxn32vy32OwLOHcsd7Bxbz0Jp4GCRXQe3io9JJAwuFtqDkhxmIC AvmnhbbxB89n56umqU3DeYfBLK5JRrlyEHLiqq8HIu20024oCOqXpxEjvn9U+gXnv7vBqO6/f8FF ycVO6AbmXo5x+PFXzPsFuDqO3vXrIrorIfNfbj2GEmswK4SIEauKO4VCpB+h+rK2+DKLUk/NbQop iIAAAik8AAMhg9L7aKhfiIGhPrW4NNDhf71yFK+uoCHCjYkQkHuC0qzQpjVlgVnny6AGXbSGOURs a0r4HrOyQELvMWsNF7yg+S72NS/NIQl7iJfJetQ3XF1BR1eAlNrYQK+tVciB/l26ECF2GKOcSSFf YFhe+OCmrW21CFnvggLXVPamEY7hDl3jXrfkJyZCLDAN+bIRscDgv1wxCgy4ioPKUqdFKEFBgibE YgrleEETkpBdG/Qi4tpArxya7FP48tjfdEWsOHSrhWNaQhtIsLyBReuRj9yWEykERaJR6oiSmlmP 6LS7rMnoRUD0EhTiRKc4seFOa9Kk0uj0IiVwcYOwjBLLZhnLKMUMDAH7g5q0VksiCcFcJHxTFuJQ yV4a85jITKYyl8nMZjozlheKpjSnSc1qWvOa2JxmF7bJzW5685vgDKc4x9nNMJjznOhMpzrXyc52 qhMJ68SDPOdJz3ra8574b8xnPaugAxvokwY7OMEJaPACDdhgBzuggT4XylB5vkAHJfgnCmwwUR0A oJ9G2EFDNzpPGniUBnU4wQt2UIc66IGhNLCBQjnKUjycoAowfYERqoACmNL0BC3N6UI9egIjFEIN RjACUD3gUZ0a9agBAQA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/shared/searchall/journals/jnci.gif R0lGODdhwgEQAMQAAMwAGP///9g7TfG6wOaAjOykrN9ba+uZo84KIfXO0++ttdMjOPnj5s8TKdIc MdtLXPjb3tg8Tvvs7uiNmOFodvPBx+R3hM0EHNUsQNlBU/3z9P77+9YzRv33+Nc3Stc4SywAAAAA wgEQAEAF/yAgjmRpnmiqrmzrvnAsz3Rt33iu73x/BwRCYDFaAAUBgcioHEAIFYpIYLgkGA2DElAg SibTpMlJMiSRB8LgNFiLBowggeGGqyOlA+ARsAD0ABRSCgkjSFuHQkRLR1VXWVtdAF9hWyRkJoUY AQ8iBAsOEgpcAJgkQgRpnkAFBQglbQBUVlhaFxQJARt+b24AQiRAI7EiBb7AYQUEoz7Nzs/QNwgU AQkYtwcFCQoODQUBBw2/AQUGEnEJCR4IFRscIhEJBeIADgF4AN7gDiYNEweEJiBooIAcgW9bBlSY gy6BBAkZAGR4+ODBuSAQfBnQwAwBAQmdREDwI0DDhG8FJv9sGACuATZt3Ni5gyePnj18+g7wK+EP IARuIja+ArCAAQR65vz0VPAzQ64JUAJgyHWQgZQRFhk8aPcOQLwCDlIxnaCQIYEEFXJR2KAswEIJ B851wgBBgpOoyxigPCgmmt+/gKEdkGdAhIPBBQ5QGGogI8B3WfE86KBAW8gGDAQIuZqBgQYDBwIM SLXBEocBCQ4c6JSTXglzEgpH9soA5IPaUCv0tUiAnoUBDzSEI6p7goOCYFsflqd4oGURmDUH4OwZ tGjSljAMkAAhgQUFWkVQg2Bg26IIG0Ro556AwgLdab4RClDYgVF6WQ1oi5gvc/kKqi0CW2FTTQeA R9V0RRD/BK0QcAFNfQwUmgIETKCBL4FlqOGGHHbo4YcghijiiCR+CIQRIe3BySGMNFHHKBEUsAEY AGgxgjIMGNIXCdQM9ccGDbCYz05DEYMAMaXU4QYCOxUzgAY7AfIHHwsg8CCLF2RwD4pYcRLjjEFZ gqOOloxgho8hLQBFASPwFRKbZ2I1jghMzvmLBrCs8SWNWgzADFFFLgnMUMIciKQxQyGDAIsIDFTi o5Dm0AcShYnwwAYLCGkEBkn+0gERVIjnlhIU8BLBPbL05cBOiowwAQSpKuHjJb4gSQySoIwACAIQ MAgABh1pQEAllVCKFaahBjJqIKaiKuSqq3gwQpYKcAqA/wUavPJJMR0UIoS0ImSJzIERAKNlpcOs kSw1FVAx1Cb4IDkuAIV2Wsyf4wopUaT89uvvvwAHLPDABBds8MEIJ6zwwgw37PDDEEcMgzAHLFkB BIuiSpQYsSAgSqoYB4XPtRDQGKsJCHhnmARsIoFPAfgoIE4sDpBVq5KG/VkKfbqOEEF3sgzL4gRm KFExnRdnHHKNI1tQMpkoj2RYeD+mKISUbPLKi30PIGOFndvl6VUAS2thASDxyNxpzcBUIIIwDxhw 6GgRIVOAyyJMMLLEfOMABDWL/DppX0x0eoFVshgwQQAR2SiRBR9orO8I4PF4hhgp0pru5p1mUOYf oVTw4P+uBVwgLNSpRgD4CJtYQMXijW+RAeSS70g5rCYQwAG2ib4nAT9sMpV7APnwYrfOnb7OONNC tOeavXa+PWwvNx5DPLHT9639DwRYIFUR9J26ReFtYNABL6EuwJGNDSQQRAU5nlyCAhJYninjF5is OfX802xtz3/oAAYAMQCofGMRQjqE9/5nBANEoDDqUwD73AeF+E1OBArogAkeMJo5sOkXRDADBYKn wRIgIyRC4BXykgfB9SnhQe8ZAv+iR6/sza1N1ztZ5rbHQxcYoAEICMA7koZBMDQATDXCXce6c4Fk AaAgSkhAkxigByEdYAuh2BUDCnPB/UHvVm64QLsA+KtmlQCAaJQrhPxYRMQngsGJUASAFEdARfld cWVz9IYH1Ci4wmzrQBAgXijy2IVxyeF6BYCS5uCYBPfBgwGBwmEwsmehnSQAXfnqSwYw1MNO3uBB ngzlM0BpA1KK8pSoTKUqV8lKE4QAADs= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/icons/shared/search/homelink.gif R0lGODlhMQAQAJECAAAAANYTNP///wAAACH5BAEAAAIALAAAAAAxABAAQAJQlI+py80BwwG0AkPn FbZj64TiSJbmiaYOlGTfC1fa5jYsUrs5TcebCgwKh0SgpPXbyWCaD0gRwSV5TY7sWXvcmLrp60pd KXYzstS5LKrXqAIAOw== ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://jnci.oxfordjournals.org/resource/image/buttons/go.gif R0lGODlhGwAUAMQEANHNyrq0r/Tz8o2CeQAgTnZpX1REN19QRN3a18bBvGtdUZiPh4F2bOjm5K+o oaSblEk4KmpZSgAAAP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEA AAQALAAAAAAbABQAAAWUYCSOZGmSBBFNbOu+MBtJamzbs7TefJvvPd4v2Bu2BItCgZFoIR7LgMBl ZA0Mg8UB0mxAFItrgSrRtQAQwAQACKgHh3PaVwYGIFOIPn4YHCEOdGYtBwwIawYBE3dSCFdTMnUu CQp6EAWQV3oKioJALQ0Ahy8IDTBVRDGoqS+rrJ6vqnUntLVlBGW5uru8vCm9wMESIQA7 ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://jnci.oxfordjournals.org/resource/css/hw.css BODY { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; BACKGROUND-COLOR: #dcd8cc; TEXT-ALIGN: center } P.hide { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #primary_nav DIV { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; = PADDING-TOP: 0px; BORDER-BOTTOM: 0px; FONT-FAMILY: verdana, sans-serif } #secondary_nav DIV { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; = PADDING-TOP: 0px; BORDER-BOTTOM: 0px; FONT-FAMILY: verdana, sans-serif } #breadcrumbs { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; = PADDING-TOP: 0px; BORDER-BOTTOM: 0px; FONT-FAMILY: verdana, sans-serif } #header DIV { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; = PADDING-TOP: 0px; BORDER-BOTTOM: 0px; FONT-FAMILY: verdana, sans-serif } #primary_footer DIV { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; = PADDING-TOP: 0px; BORDER-BOTTOM: 0px; FONT-FAMILY: verdana, sans-serif } #secondary_footer DIV { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; = PADDING-TOP: 0px; BORDER-BOTTOM: 0px; FONT-FAMILY: verdana, sans-serif } #articlenav { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-SIZE: 70%; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; = PADDING-TOP: 0px; BORDER-BOTTOM: 0px; FONT-FAMILY: verdana, sans-serif } #primary_nav UL { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; LIST-STYLE-TYPE: none } #secondary_nav UL { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; LIST-STYLE-TYPE: none } #breadcrumbs UL { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; LIST-STYLE-TYPE: none } #header UL { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; LIST-STYLE-TYPE: none } #primary_footer UL { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; LIST-STYLE-TYPE: none } #secondary_footer UL { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; LIST-STYLE-TYPE: none } #primary_nav UL LI { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #secondary_nav UL LI { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #breadcrumbs UL LI { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #header UL LI { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #primary_footer UL LI { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #secondary_footer UL LI { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #primary_nav A { COLOR: #000000 } #secondary_nav A { COLOR: #000000 } #breadcrumbs A { COLOR: #000000 } #header A { COLOR: #000000 } #primary_footer A { COLOR: #000000 } #secondary_footer A { COLOR: #000000 } #primary_footer FORM { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #primary_footer LABEL { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px } #primary_footer .inline_button { POSITION: relative; TOP: 5px } #wrap { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: 0px; PADDING-TOP: = 0px; BORDER-BOTTOM: 0px; BACKGROUND-COLOR: #ffffff } #wrap { MARGIN: auto; WIDTH: 760px; TEXT-ALIGN: left } #primary_nav { FLOAT: left; WIDTH: 100% } #secondary_nav { FLOAT: left; WIDTH: 100% } #header { FLOAT: left; WIDTH: 100%; HEIGHT: 113px } #breadcrumbs { FLOAT: left; WIDTH: 100% } #primary_footer { FLOAT: left; WIDTH: 100% } #secondary_footer { CLEAR: both; WIDTH: 100% } #content #hw { CLEAR: both; MARGIN: 0px 15px 15px } #content #hw TABLE[width=3D'640'] { MIN-WIDTH: 725px } #content #hw TABLE[width=3D'600'] { MIN-WIDTH: 725px } #primary_nav { BACKGROUND-POSITION: 264px 2px; BACKGROUND-IMAGE: = url(/resource/image/trim/nav_separator_dark_grey.gif); PADDING-BOTTOM: = 6px; PADDING-TOP: 8px; BACKGROUND-REPEAT: no-repeat; BACKGROUND-COLOR: = #b8aa9e } #primary_nav UL { FLOAT: left; MARGIN-LEFT: 4px; WIDTH: auto } #primary_nav UL LI { DISPLAY: inline; FLOAT: left; MARGIN-LEFT: 8px; WIDTH: auto; = MARGIN-RIGHT: 8px } #primary_nav UL LI.selected { BACKGROUND-POSITION: 0px 1px; PADDING-LEFT: 8px; BACKGROUND-IMAGE: = url(/resource/image/trim/arrow_white.gif); MARGIN-LEFT: 0px; = BACKGROUND-REPEAT: no-repeat } #primary_nav UL LI A:hover { BACKGROUND-POSITION: -140px 0px } #primary_nav UL LI.separator_after { MARGIN-RIGHT: 18px } #primary_nav UL LI A { FLOAT: left; BACKGROUND-REPEAT: no-repeat; HEIGHT: 9px } #primary_nav UL LI STRONG { FLOAT: left; BACKGROUND-REPEAT: no-repeat; HEIGHT: 9px } #secondary_nav { BACKGROUND-COLOR: #49382a } #primary_nav UL LI#nav_our_journals A { BACKGROUND-IMAGE: url(/resource/image/nav/our_journals.gif); WIDTH: = 93px } #primary_nav UL LI#nav_our_journals STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/our_journals.gif); WIDTH: = 93px } #primary_nav UL LI#nav_access_purchase A { BACKGROUND-IMAGE: url(/resource/image/nav/access_purchase.gif); WIDTH: = 128px } #primary_nav UL LI#nav_access_purchase STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/access_purchase.gif); WIDTH: = 128px } #primary_nav UL LI#nav_for_authors A { BACKGROUND-IMAGE: url(/resource/image/nav/for_authors.gif); WIDTH: 84px } #primary_nav UL LI#nav_for_authors STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/for_authors.gif); WIDTH: 84px } #primary_nav UL LI#nav_for_librarians A { BACKGROUND-IMAGE: url(/resource/image/nav/for_librarians.gif); WIDTH: = 97px } #primary_nav UL LI#nav_for_librarians STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/for_librarians.gif); WIDTH: = 97px } #primary_nav UL LI#nav_for_societies A { BACKGROUND-IMAGE: url(/resource/image/nav/for_societies.gif); WIDTH: = 88px } #primary_nav UL LI#nav_for_societies STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/for_societies.gif); WIDTH: = 88px } #primary_nav UL LI#nav_corporate_services A { BACKGROUND-IMAGE: url(/resource/image/nav/corporate_services.gif); = WIDTH: 134px } #primary_nav UL LI#nav_corporate_services STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/corporate_services.gif); = WIDTH: 134px } #primary_nav UL LI#nav_our_journals STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/our_journals_selected.gif) } #primary_nav UL LI#nav_access_purchase STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/access_purchase_selected.gif) } #primary_nav UL LI#nav_buy_online { MARGIN-RIGHT: 86px } #primary_nav UL LI#nav_for_authors STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/for_authors_selected.gif) } #primary_nav UL LI#nav_for_librarians STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/for_librarians_selected.gif) } #primary_nav UL LI#nav_for_societies STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/for_societies_selected.gif) } #primary_nav UL LI#nav_corporate_services STRONG { BACKGROUND-IMAGE: = url(/resource/image/nav/corporate_services_selected.gif) } #secondary_nav UL { FLOAT: right; PADDING-BOTTOM: 4px; WIDTH: auto; PADDING-TOP: 6px } #secondary_nav UL LI { DISPLAY: inline; PADDING-LEFT: 8px; FLOAT: left; WIDTH: auto; = MARGIN-RIGHT: 12px } #secondary_nav UL LI.selected { BACKGROUND-IMAGE: url(/resource/image/trim/arrow_white.gif); = BACKGROUND-REPEAT: no-repeat } #secondary_nav UL LI A:hover { BACKGROUND-POSITION: -80px 0px } #secondary_nav UL LI A { FLOAT: left; BACKGROUND-REPEAT: no-repeat; HEIGHT: 8px } #secondary_nav UL LI STRONG { FLOAT: left; BACKGROUND-REPEAT: no-repeat; HEIGHT: 8px } #secondary_nav UL LI#nav_about_us A { BACKGROUND-IMAGE: url(/resource/image/nav/about_us.gif); WIDTH: 61px } #secondary_nav UL LI#nav_about_us STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/about_us.gif); WIDTH: 61px } #secondary_nav UL LI#nav_news A { BACKGROUND-IMAGE: url(/resource/image/nav/news.gif); WIDTH: 33px } #secondary_nav UL LI#nav_news STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/news.gif); WIDTH: 33px } #secondary_nav UL LI#nav_contact_us A { BACKGROUND-IMAGE: url(/resource/image/nav/contact_us.gif); WIDTH: 74px } #secondary_nav UL LI#nav_contact_us STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/contact_us.gif); WIDTH: 74px } #secondary_nav UL LI#nav_my_account A { BACKGROUND-IMAGE: url(/resource/image/nav/my_account.gif); WIDTH: 78px } #secondary_nav UL LI#nav_my_account STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/my_account.gif); WIDTH: 78px } #secondary_nav UL LI#nav_my_basket A { BACKGROUND-IMAGE: url(/resource/image/nav/my_basket.gif); WIDTH: 67px } #secondary_nav UL LI#nav_my_basket STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/my_basket.gif); WIDTH: 67px } #user_nav { FLOAT: left; WIDTH: 100%; BACKGROUND-COLOR: #eeeeee } #user_nav FONT { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; FONT-SIZE: = 11px; FLOAT: left; PADDING-BOTTOM: 5px; MARGIN: 0px 15px; WIDTH: auto; = COLOR: brown; PADDING-TOP: 4px } #user_nav A { COLOR: #000000; TEXT-DECORATION: none } #user_nav A:hover { COLOR: #b57f0f; TEXT-DECORATION: underline } #header { BACKGROUND-REPEAT: no-repeat } #header H1#page_title { DISPLAY: block; FONT-WEIGHT: lighter; FONT-SIZE: 130%; MARGIN: 12px 0px = 0px 22px; TEXT-TRANSFORM: uppercase; COLOR: white; BACKGROUND-REPEAT: = no-repeat; FONT-FAMILY: verdana, sans-serif; HEIGHT: 14px } #header UL.emphasised LI { BACKGROUND-POSITION: 0px 5px; PADDING-LEFT: 8px; BACKGROUND-IMAGE: = url(/resource/image/trim/arrow_black.gif); BACKGROUND-REPEAT: no-repeat } #breadcrumbs { MARGIN-TOP: 10px; MARGIN-BOTTOM: 10px } #breadcrumbs UL { PADDING-LEFT: 7px; FLOAT: left; WIDTH: auto } #breadcrumbs UL LI { BACKGROUND-POSITION: 0px 0.45em; PADDING-LEFT: 8px; FLOAT: left; = BACKGROUND-IMAGE: url(/resource/image/trim/arrow_black.gif); WIDTH: = auto; MARGIN-RIGHT: 4px; BACKGROUND-REPEAT: no-repeat } #breadcrumbs UL LI.first { BACKGROUND-IMAGE: none } #primary_footer { BACKGROUND-POSITION: 194px -32px; BACKGROUND-IMAGE: = url(/resource/image/backgrounds/footer.gif); BACKGROUND-REPEAT: = no-repeat; BACKGROUND-COLOR: #00204e } #primary_footer #site_logo { MARGIN-TOP: 20px; PADDING-LEFT: 20px; FLOAT: left; WIDTH: auto } #primary_footer #site_logo STRONG { DISPLAY: block; BACKGROUND-IMAGE: = url(/resource/image/text/headings/on_blue/oj_logo.gif); MARGIN-BOTTOM: = 6px; WIDTH: 219px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 12px } #primary_footer #site_logo EM { DISPLAY: block; BACKGROUND-IMAGE: = url(/resource/image/text/headings/on_blue/oup_logo.gif); WIDTH: 177px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 6px } #primary_footer #third_nav UL { MARGIN-TOP: 26px; WIDTH: auto; MARGIN-RIGHT: 20px; TEXT-ALIGN: right } #primary_footer #third_nav UL LI { DISPLAY: inline; MARGIN-LEFT: 10px } #primary_footer #third_nav UL LI A { COLOR: #ffffff } #primary_footer #other_oup_sites { CLEAR: both; MARGIN-TOP: 20px; FLOAT: left; BACKGROUND-IMAGE: = url(/resource/image/trim/border_dotted_white_horiz.gif); MARGIN-BOTTOM: = 20px; WIDTH: 100%; BACKGROUND-REPEAT: repeat-x } #primary_footer #other_oup_sites FORM { CLEAR: both; PADDING-RIGHT: 20px; PADDING-LEFT: 20px; FLOAT: right; = PADDING-BOTTOM: 0px; WIDTH: auto; PADDING-TOP: 14px } #primary_footer #other_oup_sites FORM LABEL { FONT-SIZE: 1.4em } #primary_footer #other_oup_sites FORM SELECT { FONT-SIZE: 1.35em; FONT-FAMILY: verdana, sans-serif } #primary_footer #other_oup_sites FORM LABEL { DISPLAY: block; MARGIN-BOTTOM: 2px; COLOR: #ffffff } #secondary_footer { BACKGROUND-IMAGE: = url(/resource/image/trim/border_dotted_grey_horiz.gif); PADDING-BOTTOM: = 5px; PADDING-TOP: 5px; BACKGROUND-REPEAT: repeat-x; TEXT-ALIGN: right } #secondary_footer #copyright { WIDTH: auto; MARGIN-RIGHT: 15px } #disclaimer { BORDER-TOP: 0.1em solid; FONT-SIZE: 70%; MARGIN: 0px 15px 15px; = FONT-FAMILY: verdana, sans-serif } .journal #primary_nav { BACKGROUND-POSITION: 495px 2px } .journal #primary_nav UL LI A:hover { BACKGROUND-POSITION: -150px 0px } .journal #primary_nav UL LI#nav_subscriptions { MARGIN-RIGHT: 86px } .journal #primary_nav UL LI#nav_about_this_journal A { BACKGROUND-IMAGE: = url(/resource/image/nav/journal/about_this_journal.gif); WIDTH: 129px } .journal #primary_nav UL LI#nav_about_this_journal STRONG { BACKGROUND-IMAGE: = url(/resource/image/nav/journal/about_this_journal.gif); WIDTH: 129px } .journal #primary_nav UL LI#nav_about_this_journal STRONG { BACKGROUND-IMAGE: = url(/resource/image/nav/journal/about_this_journal_selected.gif) } .journal #primary_nav UL LI#nav_contact_this_journal A { BACKGROUND-IMAGE: = url(/resource/image/nav/journal/contact_this_journal.gif); WIDTH: 144px } .journal #primary_nav UL LI#nav_contact_this_journal STRONG { BACKGROUND-IMAGE: = url(/resource/image/nav/journal/contact_this_journal.gif); WIDTH: 144px } .journal #primary_nav UL LI#nav_contact_this_journal STRONG { BACKGROUND-IMAGE: = url(/resource/image/nav/journal/contact_this_journal_selected.gif) } .journal #primary_nav UL LI#nav_subscriptions A { BACKGROUND-IMAGE: url(/resource/image/nav/journal/subscriptions.gif); = WIDTH: 96px } .journal #primary_nav UL LI#nav_subscriptions STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/journal/subscriptions.gif); = WIDTH: 96px } .journal #primary_nav UL LI#nav_subscriptions STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/journal/subscriptions.gif) } .journal #primary_nav UL LI#nav_current_issue A { BACKGROUND-IMAGE: url(/resource/image/nav/journal/current_issue.gif); = WIDTH: 96px } .journal #primary_nav UL LI#nav_current_issue STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/journal/current_issue.gif); = WIDTH: 96px } .journal #primary_nav UL LI#nav_current_issue STRONG { BACKGROUND-IMAGE: = url(/resource/image/nav/journal/current_issue_selected.gif) } .journal #primary_nav UL LI#nav_archive A { BACKGROUND-IMAGE: url(/resource/image/nav/journal/archive.gif); WIDTH: = 53px } .journal #primary_nav UL LI#nav_archive STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/journal/archive.gif); WIDTH: = 53px } .journal #primary_nav UL LI#nav_archive STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/journal/archive_selected.gif) } .journal #primary_nav UL LI#nav_search A { BACKGROUND-IMAGE: url(/resource/image/nav/journal/search.gif); WIDTH: = 48px } .journal #primary_nav UL LI#nav_search STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/journal/search.gif); WIDTH: = 48px } .journal #primary_nav UL LI#nav_search STRONG { BACKGROUND-IMAGE: url(/resource/image/nav/journal/search.gif) } .journal #secondary_footer #issn { PADDING-LEFT: 10px; FLOAT: left; WIDTH: 50%; TEXT-ALIGN: left } #header STRONG#page_logo { DISPLAY: block; BACKGROUND-IMAGE: = url(/resource/image/text/headings/on_yellow/oj_logo.gif); MARGIN: 33px = 0px 6px 22px; WIDTH: 266px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 15px } #header STRONG#page_logo A { DISPLAY: block; WIDTH: 266px; HEIGHT: 15px } #header EM#tag_line { DISPLAY: block; BACKGROUND-IMAGE: = url(/resource/image/text/headings/on_yellow/tag_line.gif); MARGIN: 0px = 0px 6px 22px; WIDTH: 201px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 5px } .journal #secondary_nav STRONG#page_logo { BACKGROUND-POSITION: left top; FLOAT: left; BACKGROUND-IMAGE: = url(/resource/image/text/headings/on_black/oj_logo.gif); MARGIN: 4px 0px = 0px 22px; WIDTH: 142px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 9px } .journal #secondary_nav STRONG#page_logo A { DISPLAY: block; WIDTH: 142px; HEIGHT: 9px } #ads_one { CLEAR: left } #ads_one IMG { BORDER-RIGHT: medium none; BORDER-TOP: medium none; BORDER-LEFT: medium = none; BORDER-BOTTOM: medium none } #ads_two IMG { BORDER-RIGHT: medium none; BORDER-TOP: medium none; BORDER-LEFT: medium = none; BORDER-BOTTOM: medium none } #ads_two { MARGIN-BOTTOM: 10px; MARGIN-LEFT: 15px } #oas_top { MARGIN-TOP: 15px; MARGIN-BOTTOM: 10px; TEXT-ALIGN: center } #oas_bottom { MARGIN-BOTTOM: 10px; TEXT-ALIGN: center } .collection_count_nonzero { FONT-WEIGHT: bold; FONT-SIZE: 95%; COLOR: red; FONT-FAMILY: sans-serif } .collection_count_iszero { FONT-SIZE: 80%; COLOR: gray; FONT-FAMILY: sans-serif } P.hide { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #primary_nav UL LI A SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #primary_nav UL LI STRONG SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #secondary_nav UL LI A SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #secondary_nav UL LI STRONG SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #secondary_nav STRONG SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #header STRONG SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #header EM SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #header H1 SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #header H2 SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #page_title H1 SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #primary_footer STRONG SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } #primary_footer EM SPAN { DISPLAY: block; OVERFLOW: hidden; WIDTH: 0px; HEIGHT: 0.1em } P.hide { MARGIN-BOTTOM: -0.1em } #articlenav { PADDING-RIGHT: 20px; TEXT-ALIGN: right } ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://jnci.oxfordjournals.org/resource/css/jnci.css .jnci #header { BACKGROUND-IMAGE: url(/resource/image/backgrounds/header_jnci.jpg); = HEIGHT: 97px } .jnci #header H1#page_title { MARGIN-TOP: 40px; BACKGROUND-IMAGE: = url(/resource/image/text/titles/title_jnci.jpg); WIDTH: 577px; HEIGHT: = 37px } .jnci #header H1#page_title A { DISPLAY: block; WIDTH: 577px; HEIGHT: 37px } ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://jnci.oxfordjournals.org/resource/css/print.css BODY { FONT-FAMILY: serif } P.hide { DISPLAY: none } #primary_nav { DISPLAY: none } #secondary_nav { DISPLAY: none } ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jnci.oxfordjournals.org/resource/js/main.js function redirect(targ,selObj,restore) {=0D eval(targ + = ".location=3D'" + selObj.options[selObj.selectedIndex].value + "'");=0D = if (restore) selObj.selectedIndex=3D0;=0D} =0A= function prepareErrorLinks() {=0D if( ! document.getElementsByTagName = ) return false;=0D if( ! document.getElementById ) return false;=0A= if( ! document.getElementById( "validationerror" ) ) return = false;=0D var errorLinks =3D document.getElementById( = "validationerror" ).getElementsByTagName( "a" );=0D for( var i=3D0; i = < errorLinks.length; i++ ) {=0D errorLinks[i].onclick =3D = function() {=0D var objectId =3D this.href.substr( = this.href.indexOf( "#" ) + 1 );=0D if( = document.getElementById(objectId) ) {=0D = document.getElementById(objectId).focus();=0D }=0D = }=0D }=0D}=0D=0Dwindow.onload =3D prepareErrorLinks;=0A= =0A= var supported =3D ( document.layers || document.getElementById || = document.all );=0A= =0A= function encrypt(part1,part2,part3) {=0A= var all=3D 'mai'+'lto:'+part1+"@"+part2;=0A= if( part3 ) all +=3D '?Sub'+'ject=3D'+part3; = document.location.href=3Deval('"'+all+'"');=0A= }=0A= =0A= function toggle_display( id ) {=0A= if( supported ) {=0A= if( document.layers && document.layers[id] ) {=0A= document.layers[id].display =3D ( = document.layers[id].display =3D=3D 'block' ? 'none' : 'block' );=0A= } else if( document.getElementById && = document.getElementById(id) ) {=0A= document.getElementById(id).style.display =3D ( = document.getElementById(id).style.display =3D=3D 'block' ? 'none' : = 'block' );=0A= } else if( document.all && document.all[id] ) {=0A= document.all[id].style.display =3D ( = document.all[id].style.display =3D=3D 'block' ? 'none' : 'block' );=0A= }=0A= }=0A= }=0A= =0A= function hide( id ) {=0A= if( supported ) {=0A= if( document.layers && document.layers[id] ) {=0A= document.layers[id].display =3D 'none';=0A= } else if( document.getElementById && = document.getElementById(id) ) {=0A= document.getElementById(id).style.display =3D 'none';=0A= } else if( document.all && document.all[id] ) {=0A= document.all[id].style.display =3D 'none';=0A= }=0A= }=0A= }=0A= =0A= function unhide( id, display ) {=0A= // Default to display at block level=0A= if( ! display ) display =3D 'block';=0A= =0A= if( supported ) {=0A= // As IE does not support table-row, translate it to block=0A= if( navigator.appName =3D=3D 'Microsoft Internet Explorer' && = display =3D=3D 'table-row' ) display =3D 'block';=0A= =0A= if( document.layers && document.layers[id] ) {=0A= document.layers[id].display =3D display;=0A= } else if( document.getElementById && = document.getElementById(id) ) {=0A= document.getElementById(id).style.display =3D display;=0A= } else if( document.all && document.all[id] ) {=0A= document.all[id].style.display =3D display;=0A= }=0A= }=0A= }=0A= =0A= function visible( id ) {=0A= if( supported ) {=0A= if( document.layers && document.layers[id] ) {=0A= if( document.layers[id].display =3D=3D 'none' ) return 0;=0A= } else if( document.getElementById && = document.getElementById(id) ) {=0A= if( document.getElementById(id).style.display =3D=3D 'none' = ) return 0;=0A= } else if( document.all && document.all[id] ) {=0A= if( document.all[id].style.display =3D=3D 'none' ) return 0;=0A= }=0A= return 1;=0A= }=0A= return 0;=0A= }=0A= =0A= function removeSpaces(string) {=0A= var tstring =3D "";=0A= string =3D '' + string;=0A= splitstring =3D string.split(" ");=0A= for(i =3D 0; i < splitstring.length; i++) tstring +=3D = splitstring[i];=0A= return tstring;=0A= }=0A= =0A= var selectItems =3D new Object();=0A= =0A= function setOptions( listname, selectedItem, optionList ) {=0A= optionList.options.length =3D 0;=0A= optionList[0] =3D new Option( "Please select", "", true, false );=0A= =0A= if( selectItems[listname][selectedItem] ) {=0A= var newList =3D selectItems[listname][selectedItem];=0A= if( selectedItem !=3D "" ) {=0A= for( var i =3D 0; i < newList.length; i++ ) {=0A= optionList.options[i+1] =3D new Option( newList[i].text, = newList[i].value ? newList[i].value : newList[i].text );=0A= }=0A= }=0A= }=0A= }=0A= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jnci.oxfordjournals.org/javascript/ajax/xmlhttprequest.js /*=0A= =0A= Cross-Browser XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jnci.oxfordjournals.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else if (name =3D=3D "margin-right") {=0A= e.style.marginRight =3D value;=0A= }=0A= else if (name =3D=3D "margin-top") {=0A= e.style.marginTop =3D value;=0A= }=0A= else if (name =3D=3D "min-height") {=0A= e.style.minHeight =3D value;=0A= }=0A= else if (name =3D=3D "overflow") {=0A= e.style.overflow =3D value;=0A= }=0A= else if (name =3D=3D "overflow-x") {=0A= e.style.overflowX =3D value;=0A= }=0A= else if (name =3D=3D "overflow-y") {=0A= e.style.overflowY =3D value;=0A= }=0A= else if (name =3D=3D "padding") {=0A= e.style.padding =3D value;=0A= }=0A= else if (name =3D=3D "padding-bottom") {=0A= e.style.paddingBottom =3D value;=0A= }=0A= else if (name =3D=3D "padding-left") {=0A= e.style.paddingLeft =3D value;=0A= }=0A= else if (name =3D=3D "padding-right") {=0A= e.style.paddingRight =3D value;=0A= }=0A= else if (name =3D=3D "padding-top") {=0A= e.style.paddingTop =3D value;=0A= }=0A= else if (name =3D=3D "page-break-after") {=0A= e.style.pageBreakAfter =3D value;=0A= }=0A= else if (name =3D=3D "page-break-before") {=0A= e.style.pageBreakBefore =3D value;=0A= }=0A= else if (name =3D=3D "pixelBottom") {=0A= e.style.pixelBottom =3D value;=0A= }=0A= else if (name =3D=3D "pixelHeight") {=0A= e.style.pixelHeight =3D value;=0A= }=0A= else if (name =3D=3D "pixelLeft") {=0A= e.style.pixelLeft =3D value;=0A= }=0A= else if (name =3D=3D "pixelRight") {=0A= e.style.pixelRight =3D value;=0A= }=0A= else if (name =3D=3D "pixelTop") {=0A= e.style.pixelTop =3D value;=0A= }=0A= else if (name =3D=3D "pixelWidth") {=0A= e.style.pixelWidth =3D value;=0A= }=0A= else if (name =3D=3D "posBottom") {=0A= e.style.posBottom =3D value;=0A= }=0A= else if (name =3D=3D "posHeight") {=0A= e.style.posHeight =3D value;=0A= }=0A= else if (name =3D=3D "position") {=0A= e.style.position =3D value;=0A= }=0A= else if (name =3D=3D "posLeft") {=0A= e.style.posLeft =3D value;=0A= }=0A= else if (name =3D=3D "posRight") {=0A= e.style.posRight =3D value;=0A= }=0A= else if (name =3D=3D "posTop") {=0A= e.style.posTop =3D value;=0A= }=0A= else if (name =3D=3D "posWidth") {=0A= e.style.posWidth =3D value;=0A= }=0A= else if (name =3D=3D "right") {=0A= e.style.right =3D value;=0A= }=0A= else if (name =3D=3D "ruby-align") {=0A= e.style.rubyAlign =3D value;=0A= }=0A= else if (name =3D=3D "ruby-overhang") {=0A= e.style.rubyOverhang =3D value;=0A= }=0A= else if (name =3D=3D "ruby-position") {=0A= e.style.rubyPosition =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-3dlight-color") {=0A= e.style.scrollbar3dLightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-arrow-color") {=0A= e.style.scrollbarArrowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-base-color") {=0A= e.style.scrollbarBaseColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-darkshadow-color") {=0A= e.style.scrollbarDarkShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-face-color") {=0A= e.style.scrollbarFaceColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-highlight-color") {=0A= e.style.scrollbarHighlightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-shadow-color") {=0A= e.style.scrollbarShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-track-color") {=0A= e.style.scrollbarTrackColor =3D value;=0A= }=0A= else if (name =3D=3D "float") {=0A= e.style.styleFloat =3D value;=0A= }=0A= else if (name =3D=3D "table-layout") {=0A= e.style.tableLayout =3D value;=0A= }=0A= else if (name =3D=3D "text-align") {=0A= e.style.textAlign =3D value;=0A= }=0A= else if (name =3D=3D "text-align-last") {=0A= e.style.textAlignLast =3D value;=0A= }=0A= else if (name =3D=3D "text-autospace") {=0A= e.style.textAutospace =3D value;=0A= }=0A= else if (name =3D=3D "text-decoration") {=0A= e.style.textDecoration =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationBlink") {=0A= e.style.textDecorationBlink =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationLineThrough") {=0A= e.style.textDecorationLineThrough =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationNone") {=0A= e.style.textDecorationNone =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationOverline") {=0A= e.style.textDecorationOverline =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationUnderline") {=0A= e.style.textDecorationUnderline =3D value;=0A= }=0A= else if (name =3D=3D "text-indent") {=0A= e.style.textIndent =3D value;=0A= }=0A= else if (name =3D=3D "text-justify") {=0A= e.style.textJustify =3D value;=0A= }=0A= else if (name =3D=3D "text-kashida-space") {=0A= e.style.textKashidaSpace =3D value;=0A= }=0A= else if (name =3D=3D "text-overflow") {=0A= e.style.textOverflow =3D value;=0A= }=0A= else if (name =3D=3D "text-transform") {=0A= e.style.textTransform =3D value;=0A= }=0A= else if (name =3D=3D "text-underline-position") {=0A= e.style.textUnderlinePosition =3D value;=0A= }=0A= else if (name =3D=3D "top") {=0A= e.style.top =3D value;=0A= }=0A= else if (name =3D=3D "unicode-bidi") {=0A= e.style.unicodeBidi =3D value;=0A= }=0A= else if (name =3D=3D "vertical-align") {=0A= e.style.verticalAlign =3D value;=0A= }=0A= else if (name =3D=3D "visibility") {=0A= e.style.visibility =3D value;=0A= }=0A= else if (name =3D=3D "white-space") {=0A= e.style.whiteSpace =3D value;=0A= }=0A= else if (name =3D=3D "width") {=0A= e.style.width =3D value;=0A= }=0A= else if (name =3D=3D "word-break") {=0A= e.style.wordBreak =3D value;=0A= }=0A= else if (name =3D=3D "word-spacing") {=0A= e.style.wordSpacing =3D value;=0A= }=0A= else if (name =3D=3D "word-wrap") {=0A= e.style.wordWrap =3D value;=0A= }=0A= else if (name =3D=3D "writing-mode") {=0A= e.style.writingMode =3D value;=0A= }=0A= else if (name =3D=3D "z-index") {=0A= e.style.zIndex =3D value;=0A= }=0A= else if (name =3D=3D "zoom") {=0A= e.style.zoom =3D value;=0A= }=0A= }=0A= catch (e) {=0A= /* ignore error on attempt to set e.style.[property] */=0A= }=0A= }=0A= }=0A= }=0A= ------=_NextPart_000_0005_01C89B03.81BA8170 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jnci.oxfordjournals.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. For now we have to disable=0A= * the callback until we can track down a proper fix=0A= * (or everybody sanely upgrades to version 6 or 7!).=0A= */=0A= if (navigator) {=0A= var appname =3D navigator.appName;=0A= if (appname =3D=3D "Microsoft Internet Explorer") {=0A= var userAgent =3D navigator["userAgent"];=0A= var s =3D "MSIE ";=0A= var n =3D -1; =0A= if ((n =3D userAgent.indexOf(s)) !=3D -1) {=0A= var v =3D parseFloat(userAgent.substring(n+s.length));=0A= if (v < 6) {=0A= return;=0A= }=0A= }=0A= }=0A= }=0A= =0A= /*=0A= * Acquire table row element to update, initiate callback=0A= * to update table with Entrez Links.=0A= */=0A= var tr =3D document.getElementById('entrez_callback_'+pmid);=0A= if (!tr) {=0A= return;=0A= }=0A= var req =3D new XMLHttpRequest();=0A= if (!req) {=0A= return;=0A= }=0A= req.onreadystatechange =3D function() {=0A= if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || req.status = =3D=3D 304)) {=0A= var src =3D req.responseXML.documentElement;=0A= var dst =3D document.createDocumentFragment();=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], dst);=0A= }=0A= var tbl =3D tr.parentNode;=0A= tbl.replaceChild(dst, tr);=0A= }=0A= }=0A= req.open('GET', callback_url, true);=0A= req.send(null);=0A= }=0A= ------=_NextPart_000_0005_01C89B03.81BA8170--