Intraventricular Glioblastoma Multiforme with = Previous History of Intracerebral Hemorrhage : A Case Report

<= LINK=20 rel=3Dstylesheet type=3Dtext/css=20 href=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcrefs5.css"> =

Journal=20 List > J=20 Korean Neurosurg Soc > v.4= 4(6);=20 Dec 2008

PubMed articles by:

J Korean Neurosurg = Soc.=20 2008 = December;=20 44(6):=20 405=E2=80=93408.

Published online 2008 = December 31.=20 doi:=20 10.3340/jkns.2008.44.6.405.

PMCID:=20 PMC2615149

Intraventricular Glioblastoma Multiforme = with Previous=20 History of Intracerebral Hemorrhage : A Case Report

Young-Jin Kim, = M.D., Sang=20 Koo Lee, M.D., Ph.D.,=20 Maeng Ki Cho, M.D., Ph.D., and Young-Joon Kim, M.D.,=20 Ph.D.

Department of Neurosurgery, Dankook = University College=20 of Medicine, Cheonan, Korea.

Corresponding=20 author.

Address for reprints: Sang Koo Lee, M.D., = Ph.D.=20 Department of Neurosurgery, Dankook University College of = Medicine,=20 Anseo-dong, Cheonan 330-715, Korea. Tel: +82-41-550-3090, Fax:=20 +82-041-556-0524, Email: lsk99999/at/dreamwiz.com

Received May 16, 2008; Accepted November = 24,=20 2008.

Abstract

GBM is the most = common=20 primary brain tumor, but intraventricular GBM is rare and only few = cases=20 have been reported in the literature. The authors report a case of = 64-year-old man who had a remote history of previous = periventricular=20 intracerebral hemorrhage. Brain computed tomography (CT) and = magnetic=20 resonance (MR) imaging showed an intraventricular lesion with=20 inhomogeneous enhancement, infiltrative borders and necrotic cyst, = and=20 obstructive hydrocephalus. The patient underwent surgical removal = through=20 transcortical route via the bottom of previous hemorrhage site and = the=20 final pathologic diagnosis was GBM. We present a rare case of an=20 intraventricular GBM with detailed clinical course, radiological = findings,=20 and pathological findings, and the possible origin of this lesion = is=20 discussed.

Keywords: Glioblastoma multiforme, Intraventricular tumor,=20 Intracerebral hemorrhage, Obstructive=20 hydrocephalus

INTRODUCTION

Lesions that affect the lateral ventricle include a large = variety of=20 benign tumors, malignant tumors, and cyst formations¹¹^,¹²⁾.=20 Tumors of the lateral ventricle may be classified by their origin = as=20 either primary or secondary form¹^,¹⁰⁾.=20 Primary tumors arise directly from structures within the lateral = ventricle=20 itself, such as ependyma, subependymal glia, choroids plexus, = embryogenic=20 remnants, and infectious or metastatic tissues¹⁾.=20 Secondary tumors arise from structures adjacent to the lateral = ventricle=20 and subsequently grow into the lateral ventricle by either gentle=20 extension or frank invasion¹⁾.=20 Regardless of their tumor origin, the majority of ventricular = tumors have=20 benign histologic findings. Only 13% had malignant lesions such as = glioblastoma, melanoma, or metastatic carcinomas¹³⁾.

Glioblastoma multiforme (GBM) within the lateral ventricle is=20 relatively infrequent and is found predominantly in the frontal = horn or=20 body. To the best of our knowledge, only a few cases of = intraventricular=20 GBM have been reported in literature⁹⁾.=20 Here, we report a case of intraventricular GBM at occipital horn = who=20 presented symptom of progressive obstructive hydrocephalus with = previous=20 remote history of intracerebral hemorrhage.

CASE REPORT

A 64-year-old man presented with a 6-week history of gait = disturbance=20 and progressive urinary incontinence. He also had memory = difficulty and=20 frequent episodes of disorientation. His gait had worsened to the = degree=20 that he could no longer ambulate without assistance. The patient = also=20 complained global headache, vomiting, and constant drowsiness = which=20 persisted for two weeks prior to visit. Urinary incontinence was = described=20 by his family members, even though he did not have a history of = the=20 prostatic disorders. On neurological examination, high cortical = function=20 was intact except for short-term memory such as digit recalling = and=20 expressive verbal memories. Both low extremities showed moderate = motor=20 weakness (muscle power grade III) and increased deep tendon = reflexes in=20 both knees. He had a past history of intracranial hemorrhage and = underwent=20 conservative management 3 years ago. At that time, brain MR = imaging showed=20 no occupying lesion in the brain except intracranial hemorrhage on = the=20 right parietal periventricular area (Fig.=20 1). The initial non-contrast brain CT scan showed obstructive=20 hydrocephalus with enlargement of the medial occipital = periventricular=20 area and isodense ventricular cystic lesion(Fig.=20 2). This finding prompted an MR imaging study, which confirmed = the=20 presence of rim-enhancing intraventricular solid and cyst = lesion(Fig.=20 3). This lesion showed infiltrative pattern around the medial=20 occipital ventricular wall and spreading into the splenium of = corpus=20 callosum and septum pellucidum. The tumor had irregular and = inhomogeneous=20 enhancing patterns on gadolinium-enhancing images. The thicker = solid=20 portion was located near the occipital horn, which had continuity = to=20 subependymal layer of previous hemorrhage site. These radiographic = findings were indicative of a high-grade tumor. The tumor might = originate=20 from paraventricular subependymal layers and spread to adjacent=20 structures.

Fig.=20 1

Brain = magnetic=20 resonance (MR) images of previous intracerebral hemorrhage = on the=20 first admission (3 years before tumor operation). T1 = weighted axial=20 (A), T2-weighted axial (B) and T1-weighted sagittal(C) MR = images=20 show early subacute stage of intracranial=20 (more ...)

Fig.=20 2

Initial = brain=20 computed tomography scan on the second admission = demonstrates a=20 large ventricle and an intraventricular lesion with = periventricular=20 edema.

Fig.=20 3

Preoperative (A, B,=20 C) and postoperative (D) magnetic resonance (MR) images on = the=20 second admission. T1-weighed Gd-enhanced MR image reveals an = enhancing huge intraventricular mass. Axial (A) and coronal = (B)=20 images show that the heterogenously rim-enhancing=20 (more ...)

A parieto-occipital craniectomy with a transcortical approach = to the=20 lesion was performed. We were able to access the lesion via route = of=20 previous hemorrhage site on the right parietal lobe. Grossly, the = tumor=20 was seen as hypervascular mass with hard in consistency. In = microsurgical=20 findings, it was grayish-colored tumor and was predominantly firm, = necessitating piecemeal removal. The tumor was very infiltrative = in nature=20 that no distinct plane between tumor and ependymal layer was = identified.=20 Frozen and permanent section of tumor showed mitotic figures,=20 pseudopalisading necrosis and endothelial proliferation. Most of = tumor=20 cells were stained positive for GFAP (Fig.=20 4). The pathological diagnosis was glioblastoma. After = operation, the=20 symptoms of obstructive hydrocephalus were progressively improved. = Two=20 weeks after the operation, whole brain radiation therapy was = started. His=20 family refused concomitant chemoradiotherapy with temozolomide for = the=20 reason of economic status. He did not show any neurological = deterioration=20 during radiation therapy, and he was discharged in the middle of = radiation=20 schedules. He had some memory disturbance and mild hemiparesis = (muscle=20 power grade IV) at the time of discharge.

Fig.=20 4

Microscopic=20 findings confirming glioblastoma multiforme. Necrosis with = the=20 pseudopalisading pattern of malignant nuclei and endothelial = cell=20 proliferation (A:=C3=97100). A strong positive glioblastoma = multiforme=20 (GFAP) stain is noted (B:GFAP,=C3=97400).=20 (more ...)

DISCUSSION

According to the WHO classification which was first published = in 1979=20 and modified in 1993, GBM is grade 4 which shows nuclear atypia, = mitosis,=20 and endothelial proliferation or necrosis. Glioblastoma represents = 15%-20%=20 of all intracranial tumors and approximately 50% of gliomas in=20 adults⁸⁾.=20 Although capable of arising anywhere in the CNS, these tumors = mainly=20 present as a frontotemporal lesion (63%) of the cerebral = cortex¹⁴⁾.=20 But, intraventricular glioblastoma multiforme (GBM) is relatively = rare and=20 is usually found predominantly in the frontal horn or body.

Intraventricular tumors can be categorized into two types = according to=20 their origin : primary and secondary. Neoplasms that originate = from the=20 ventricular wall and its lining are considered primary ventricular = tumors,=20 and those that arise in adjacent brain structures but with more = than=20 two-thirds of exophytic growth within the ventricle are considered = secondary ventricular tumors with transependymal development = (primary=20 cerebral origin)²⁾.=20 The most common intraventricular gliomas include ependymomas,=20 subependymomas, and subependymomal giant cell astrocytomas. Other = less=20 common variants, including choroids glioma, glioblastoma = multiforme, and=20 mixed glial-neuronal tumors, have been reported⁴⁾.

The authors hypothesize that the origin of tumor in this case = was the=20 neuroglial cells of the white matter in the subventricular area. = This=20 periventricular glioblastoma may have grown into the ventricle by=20 transependymal invasion and infiltrated into surrounding = structures.=20 Although we do not know the exact relationship between previous = hemorrhage=20 and the development of glioblastomas, we can consider two possible = mechanisms of the previous hemorrhage and glioblastomas. One = mechanism is=20 tumor bleeding event during the development of hypervascular = tumors. In=20 our case, 3 years of long history did not meet the natural history = of=20 glioblastomas, since glioblastomas usually show rapid progression = and=20 recurrence after the treatment. Additionally, the patient had long = history=20 of symptom free survival during untreated periods. So, this = mechanism may=20 be ruled out. The other is abnormal repair mechanism near the=20 periventricular white matter which was injured by previous = hemorrhage. The=20 enhancing portion of the tumor was mainly located below the bottom = of=20 previous hemorrhage site on the sagittal image (Fig.=20 3C) and thicker solid portion of the lesion was located in = occipital=20 area had continuity to previous hemorrhage site (Fig.=20 3A). According to the radiological findings, we hypothesized = that the=20 development of periventricular GBM may triggered by the abnormal = healing=20 process in the subependymal zone. Subependymal zone have many = pluripotent=20 stem cells for regeneration after cell death. Doetsch et = al.³⁾=20 introduced four distinct cell types reside in the subventricular = zone=20 (SVZ); The ependymal cells, astrocyte-like type B cells, type C = cells and=20 oligodendrocyte progenitors. The role of multipotential = progenitors and=20 neural stem cells in the adult SVZ as the cell origin of = glioblastoma has=20 been suggested by studies on human tumors⁶⁾=20 and transgenic mice⁵⁾.=20 Our case might be a case of malignant transformation of the = quiescent=20 neural stem cell or fast-proliferating multipotential progenitors = residing=20 in the adult SVZ during the repair process. Although we cannot = explain the=20 exact mechanism of malignant transformation, we think that = abnormal=20 subependymal healing process after massive hemorrhage might = trigger the=20 glial proliferation from neural stem cells in SVZ.

Considering MR imaging, the tumor which entered the ventricle = might=20 have expanded along the ependymal lining to the frontal horn and = have=20 constituted a necrotic cyst. Also, the glioblastoma might have = invaded the=20 opposite frontal lobe probably by crossing through the ependymal = layer=20 and/or corpus callosum. This maybe the result of invasion through = the=20 subependymal fascicular route.

Intraventricular GBMs have typical imaging characteristics of=20 high-grade gliomas, including contrast enhancement and, sometimes=20 inhomogeneity and infiltrative, irregular borders⁷^-⁹⁾.=20 Well-circumscribed, minimally enhancing appearance of = intraventicular GBM=20 at the trigone was reported in only one case⁹⁾.=20 Most lateral ventricular tumors enlarge slowly and typically cause = no=20 symptoms until reaching a size large enough to cause obstructive=20 hydrocephalus or compression of surrounding eloquent = structures⁹⁾.=20 However, the interval between symptom onset and presentation is = short,=20 ranging between weeks and months¹⁰⁾.=20 Symptoms caused by obstructive hydrocephalus in this case were = consistent=20 with a large ventricular tumor.

Top

CONCLUSION

Intraventricular tumors show slowly progressive symptoms due to = obstructive hydrocephalus or compression of surrounding eloquent=20 structures. We experienced a rare case of an intraventricular GBM = at the=20 occipital horn of lateral ventricle which expanded by subependymal = invasion to the ipsilateral and contralateral frontal horns and = revealed=20 an inhomogenous wall with necrosis.

Abbreviations

CNS	central nervous system
CT	computed tomography
GBM	glioblastoma multiforme
GFAP	glial fibrillary acidic protein
MR	magnetic resonance
WHO	World Health = Organization

References

Amar, AP; Ghosh, S; Apuzzo, MLJ. Ventricular = tumors.=20 In: Winn HR. , editor. Youman's = Neurosurgical=20 Surgery. 5th ed. Philadelphia: Saunders; 2003. pp.=20 1237=E2=80=931264.

D'Angelo, VA; Galarza, M; Catapano, D; Monte, = V;=20 Bisceglia, M; Carosi, I. Lateral ventricular tumors surgical = stragies=20 according to tumor origin and development a series of 72 cases.=20 Neurosurgery. 2005;56(Suppl 1):36=E2=80=9345. = discussion 36-45. [PubMed]

Doetsch, F; Caille, I; Lim, DA; = Garcia-Verdugo, JM;=20 Alvarez-Buylla, A. Subventricular zone astrocytes are neural stem = cells in=20 adult mammarian brain. Cell.=20 1999;97:703=E2=80=93716. [PubMed]

Dumont, AS; Farace, E; Schiff, D; Shaffrey, = ME.=20 Intraventricular gliomas. Neurosurg Clin N=20 Am. 2003;14:571=E2=80=93591. [PubMed]

Holland, EC. A mouse model for glioma : = biology,=20 pathology, and therapeutic opportunities. Toxicol Pathol. 2000;28:171=E2=80=93177. [PubMed]

Ignatova, TN; Kukekov, VG; Laywell, ED; = Suslov, ON;=20 Vrionis, FD; Steindler, DA. Human cortical glial tumors contain = neural=20 stem-like cells expressing astroglial and neuronal markers in = vitro.=20 Glia. 2002;39:193=E2=80=93206. [PubMed]

Lee, TT; Manzano, GR. Third ventricular = glioblastoma=20 multiforme; case report. Neurosurg = Rev.=20 1997;20:291=E2=80=93294. [PubMed]

Lopes, MBS; VandenBerg, SR; Scheithauer, BW.=20 Histopathology, immunochemistry and ultrastructure of brain = tumors. In:=20 Kaye AH, Laws ER Jr. , editors. Brain=20 tumors. 1st ed. New York: Churchill Livingstone; 1995. pp.=20 125=E2=80=93162.

Park, P; Choksi, VR; Gala, VC; Kaza, AR; = Murphy, HS;=20 Ramnath, S. Well-circumscribed, minimally enhancing glioblastoma=20 multiforme of the trigone; a case report and review of the = literature.=20 AJNR Am J Neuroradiol. = 2005;26:1475=E2=80=931478. [PubMed]

10.

Pendl, G; Ozturk, E; Haselsberger, K. Surgery = of=20 tumours of the lateral ventricle. Acta=20 Neurochir (Wien). 1992;116:128=E2=80=93136. [PubMed]

11.

Piepmeier, JM. Tumors and approaches to the = lateral=20 ventricles; introduction and overview. J=20 Neurooncol. 1996;30:267=E2=80=93274.=20 [PubMed]

12.

Rabb, CH; Apuzzo, MLJ. Options in the = management of=20 ventricular masses. In: Tindall GT, Cooper PR, Barrow DL. , = editors. The Practice of Neurosurgery. 1st ed. = Baltimore:=20 Williams & Wilkins; 1996. pp. 1229=E2=80=931242.

13.

Ribalta, T; Fuller, GN. Brain Tumors : an = overview of=20 histopathologic classification. In: Winn HR. , editor. Youman's neurosurgical surgery. 5th ed. = Philadelpia: Saunders; 2003. pp. 661=E2=80=93672.

14.

Salcman, M. Glioblastoma and malignant = astrocytoma. In:=20 Kaye AH, Laws ER Jr. , editors. Brain=20 tumors. 1st ed. New York: Churchill Livingstone; 1995. pp.=20 449=E2=80=93477.

Articles=20 from Journal of Korean=20 Neurosurgical Society are provided here courtesy of =
The=20 Korean Neurosurgical Society

------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/pmc3_logo_v5.gif R0lGODlhkQBLAMYAAKm5x+v0+IekvHefv+Tp7liXuQBcknmcuoapxDqGrsXP3yhpmrnEzrzL3FqG qgFmmTp1os7W3YWyysPT4Uh4peHn7Oru88TN1ip7p8nS2Rxjl6zB1ejs8d3k6mmStfP6+6zE2Nrg 5kKLsb7I0bbBy9Lm7sfP2HKlwy9tnLnU4pGswaW+0kyCqpvB1bfJ3GWRs9La4A5YkGGcvOLo7a/N 3dvi57nQ3qLD1s7c5pq1y6+8x5+zxLDG2JK4ztXc45e80cLZ5drq8eXq78vg6rXG1HmrxmGOsMne 6WCKrtnf5ZGyy1mKsDVyoMrT4rvGz3Cau9/l68PM1cDJ0k6Stunt8Rdvn2mhv1N9qNfg6dDX39Pe 6n+uyIe40MHL1OTv9XWoxefr76DG2Nbd4+Lu9J+4zRlflNnj68Xe6pexxu7w8dHa59nd6afJ2uvu 8G6Wtufs8OHo8dTb4urt8MvU2+zv9dLc5evu9ezr8maUtwBPiuzx9P///2aZzDNmmczY5Ozw9CwA AAAAkQBLAEAH/oB7goOEhYaHiImKi4yNjo+Qinx+lJWWl5iZmpuclX+foKGio6SlpqeoqaJ8gpOd lVhbVhJee2NAXC1DjEGyWxWvnqqhEHlLG0t5eTkVBG9UFp88ymBCQs/TMXksFRN52hAVMwRg0KPT edXX5qase66YTywe9EYoGgv5GvP19/ooSzy88LAEn74qCaYonFJFgxJNw0BRKebhghMGDJwgURaj TB4kAvIwUZbHDYOQKEg4yHMFwMoFOnRoIAmBBAkUynDmIcGgS4QkFai0a7XpxA8FE04YuCGkQgUw Mno0aFAgT4+mFYRIAOGiiQgDNmZAgTLDBgikCQy0mAExIigL/nA74IEAQYkFKlTe6H3DAS+Hv33x WuDBwwzew9AQBx4wwM/evnBRuYN3yUoCGQVkMDRAgwCBLwkyY66yFMyME1MKqC7wIAEUpxIuiyYN pK3bT1S0LTHBQNuAYi9MqDCiQoWyC8bzSBmhTACDlShGSNEmwAROI8zzqBgRJYKYDmCinZocrLz5 87dD3W3aIUSSJCFqdOhQo379+fjz068RIr78+fz1199/ZAnBznhEVeJBHwzq4aCDDEYo4YQUVtgH hBZ6cEkoZFiIoYUghjjhhxfqMaKJHkpIRijkVaIABSLGKCOIFEywoURIzKjjjjyCiIRQoLR43pBE 3pjekUgm/hlkgkU2OaSSUEY5jJBOFhHaLnsEcYIIJzgpjJRghrnkO5mgwUIZEDiAhANXoLDAFQ6w ecWcdNZp5510rolCGS8QkcltFhRDUkkM4PTCHCO5QYYyGUShDBo5iBRSMUhshIITOJXBhEduuCFS EovmYYIJGcBQwwxAkkLlJUWwsYYWWzyAQQK00npDE2pURasIIiSAwQRNmDGFARj0SusPE7z6FRub AApGBTX4AIMPIXQARQdJZJHBBVF00cUFJkQB7qgZzDFHBuVmQCq65Z5LLrrmqktuFklAIYR4qjKJ yRc0YNHAF0sR4BRUNkxV1VUD93BEV1+FNd8MKQDRxARp/rXQ7JHe5LFCEjAI0CcR3zwRQwxYgKCM BjPFQICgInlaTF15oDCAMmTMoMzGSXSQVapDkenlz68gScUMNcDQaBfiXsDtCBg54bR0F40wghPS Lef000hHIcVFNvFE9QX0QvFGKqsCbbYlYqYNJpUUPtjggx/CXWKEJM5tt4RG/gEihBjyjaLfdP+N YomAB34i4YPXzaK+Zzfuh9qQK1m240BHbnl6k1Pu5eWcT8n4z7063vnoCPpMpAQFbFFLALi0EAAh eqAmQZPpKcEYYyvAhS8oODAmSu+M4QCX7QPYtfsowLuVeSU9bLFFEIIMEQYbQHwQCSFAfLHFDx1w Amgx/k+IcYEyLyTaQTEDbKAMBRSI1MEKeUAwEhEs5OGBSFmAHIPIJGOhDR46SYIYcjaD8PSMMpVQ AQ6ux8BBNOAKf3JLoOx3AQZ0DSdIGMF1kmPBRxkHBQzwSB508BIdjAQJUhiOCjyFAuEoAyPdAQrP VvE5SmAGAzjEQBUewEMe5hCHO+yhrH4oRB8SsQo4sM0wLECAom3rAhmIQBayMAeLYKRrFvRaRqSG kSzypGlTa9rTwrhFE8AgBEE5YFGOkhQDsCENcpBDGqJisDz8AI5y3ArDDDCDNoABDG1IwVkoppaL SfANQpiBOK7BATAQAAo1eM97BAQf/1hLP/q5ln3u/kMfAcmngAcaxfKMghSl3OCRWaEjVazySCgQ QI9eAUsF5lMBs6ClkEq8TTJiQAYEKGMCzXjG8UahDBD8UZimKKY1yhEZydSQElsowR7SsAU3vmEc crBCLTpQlR/IQQiAnMLr7jAsIGAFDH6wHhy+EgZD3gYdZKiity6QqU2VJFSgUkYcYPCoCxghD2WI wLQ24AYmaMMN/MwDGsp1xgqMzZmmu0QPEmCFihZBBAvAgrV+IIKKVlQEGMBBBaAgg4561FdmmM8P MCCBim5BBFWoTQTTw4E6jIQkByjXAmhCgpDk4SQvJIGgUAAdnugkBsVwgA6awwApzOE7BiwdAjX3 /jMkWeCaNYjDHEa1LneRilTmOldY5xABr4JVimU1gdKiEAWwZuE7qCLbM6laJCjBBS98QYxfAqNX vXJAL3z1C2D5qjvPRdQPIIBRjxY7IQqAABOigEKOGEvZyk4ICVCgYUQN1za3va1vnpXb3OrGoLzt TXCgfRviEJe40A7ubqpdrWgZtLjNxna0grNb4XRrotROKG+KjW3hhtvb1qo2tSSqG3FhS4HaTrUJ AoCAZXcEAQE0YaYSIUNwp8tdGVGADDP8w/Lo+iTSmVezDUyvetfL3vZKgg/wja9850vf+tr3vvjN r373y9/++pe+cyUves5LYPEGWMDlKTCBx4vg/mAo+LwMbnAnHmzeCAfjDUoQgQxK+oWzUZh0Fi7K FE4AvQAM4XV78MJLt7C5D3cuxJYoQgG+UAsvpIALXMCSIbRwggIUwQzldQvLlMECMAgTX+i4CzQG Q5IB/GUm8fvLkkmRZMEMU7NTzcQNkEWDAHzgCC2gARCk+QgvsIEGPbiBg28DPmwpww1GgIAKhDAX JaDjBXlYgAsIYLJixCAEvmwfE/qTg5mgwAZwWcFMkpGHkRYolFjeBGa+AAQH0aAIW6ABHOwgBDh4 +tOgDnWohUAHOgDBCiLocC5TMUEmeGCnedgBTjwghpE8AX6iAlkeXLAoJiTjAGVAAZ5RcAE8/i8h CU9YRqQ0UIFI5SELUswZAa78ickJQAVNaAAPQLABHrigAS4AgbjHTe5ym/vc3vbDACAIWQkWgwVo UMEFPxKFWaNBGVJggDKKEzMAkEQARcWJsF/wAjTgmQlZuHcepAY2NIZ3TFl2AxoasIINWLwBCsh4 xnlg8YtrPOPc7vjHQb6CG5jcBUCILnZVMREKehEnEDiANkDSnAN8A6gpGckCXJJnHbCwUNpROAk2 8tOe/CSNpcicBMKwhwAEoARp6aEBwuD0p3+Fh8QCQtWHIEQDVIEGH/BCAMaQgDxgYdWosIALVkAE EyxHXCY4gBEAoAIB7AAAAsC7AwTAE7yj/oEBeN+BDuoub5u4wQFu6JoOBqIDATiHAVGgF9LzdVhL pKYIJ0hAEXlYgBOcAAMGKGIVZHCCLwRRiBiwwhdOsMMioHPlrBZCB8RQ1jnAYIBiMFoXyEg1p0nh 99+6QBeksHupER9pwgf+PIVftShkIA6neni150pKBSilB2nI/hx78O2qbEH7FdgCVybwFRxoPw00 OIsNKuZOVdzlkfdpRiKhwDFoR0CKU8Q/DG4vBh/4QAz7FAf+938AuH/7FwdikHtTlAW31wEz8AbU ZmCVVwmk1EY3wAGeIQeqdDAYSAByAEsNc062REgWg3ZpdxdvYGRLRgUckEhO4RQzoEgv/jgO1lCD QuAZNniDMbiDnhGDMOgMkBZpmlCBpoRKQrCBrDQWr8QVsWQDs6QzI8h+JqgKOKANJIEH4AQZEfgJ ysADutNMo2ABXXgYYChVa1RKAfMaR/gDddQDApMVIAgWM/AwUYhLsBcRyvAEkDQTCJAEhRYziGYD dKEEI2MXeJATL6ACdbEEEGABA5AyA3AXyrABYzEDQsABWzh9E0gJRXAGadAAShEGWPEGMlACarBK PWAaHigCXqAGTdhKBDABY9AB62eH7ZYe6LACRqNWJoBnRhACyZYDuFYHuEYfNBMB95MHRkAECAAB K3A+efAENUAzDAhX0udcm4ABUyAB/lZiAAXgSARgBhiQOlZAGlPwR2BwA6NXBKb3ACeAFVggA7Nw AhpgAFPQfhHhB8qQA40id2QwEkxAcAWncBGgcOqybyNgKeAyMzFwJnkQHPvWVmHzUGaYCSfABSVw BEOQAmVHA+JgBT0wBBrJkXlwSlAgAmwgkkeQAjxkLRXQAxipkWcAejJ1i7fBAcmWBw6AEzHQBSjR BThRd8owAj6FEcqABCoAHRnRHDtwlPqWBwLgBF3wVOCRiTAmYTbpFlRQAUkwHG4AAOMSd0iQeCTQ eFFplhakA0+ABAewA9d2RR6ABADgloLneDpgdFAlV5uIlUFzJBYge7QXLmylNOEC/nzEt1bBB3fc 4i3ztC7MNzVUgzSlgkYcoJdZxpd9eSRU0BTRsoAM6AP7ZIDT0n8C2H8JKC0wMEX7l4AKaH8MKIA5 kxWZKIGXiZnekyR34UgzSAA6uIPj4BnAyZu9CYM0SAA+uJu8iUyWaZtB5mJlGCZl0wQH0F06cgDX lZV/YAHaRZ3cGSLfNUxU0gDS1Z06AgENkDdUMFnkuZ4W8iPYWAmcBVuWRVp4gzagsF0SQp/UmVyv JSIk0lwQZwn5yZ/HZThxk1tuQ1qm5SHFdVwIalyjZaCvpVwNilsT8p6UwKDyiVwQylkKap+fcFq8 NaIH6qAmGp+3JTeKE6CVMJ2fXHWgMLpbqzWiEnIAedMhAxqjgZOgEApaPJqjPzqjd7MiLFoJDYCf 7EkhFHCeefMHkpWkUMogmCWEzJlgLsY5V8mcV4qlB1alILqlkDMZ/zWmZFqmZnqmaApfexAIADs= ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/logo-jkneurosoc.gif R0lGODlh9AFLAPcAAH+apgBSh7+/tkBykGCAkX+cqTBigU2NtkBtiQBIeIi10wBFcq+2sp+qqkB5 ms/KvXCOnHCMmiJ2rZ+srABLfEBwjCBfhmCGmX+WnzBkhEBshkBpga+1sXCKliBgiEBvilB2i4+g pQBMfX+apEB0kzBqjhBaid/WxI+jqhBQegBCbUB2ljBqjGCLojBoiiBZfDBtkmCClBBOdkBzkkB0 lDBmiDBhfhBIbBBUgBBWgo+foyBafxBSfX+UnHCSoiBcggBAar/DvGCEl1B4jlB6kkBxj5+trhBM dE2KsxBYhmB/j1B5kEB3mCBXeRBMcnCLmK+4thBPeHCJlRBXhBBUflB+lyBbgABWjgBhnwA/aABX jwBUiwBgngBemwBblnerzABdmgBdmQBZkwBalQBcmABXkABcl/7pzwBYkQBYkgBblwBZkkSLuWag xgBSiABTiQBVjO70+QBRhrvV5pnA2QBWjwBZlBFspgBQhMzf7ABPg93q8gBUigBXjqrK3wBTigBd mFWWwDOBswBPggBalABEcQBQhQBNgABIdwBOgQBGcwBWjQBHdb/BuQBEcABRhwBYkL/AuABRhe/f yQBMft/VxABLewBTiABblb/AtwBNfwBOgu/fyr/CugBPhABKeQBKegBGdABSiQBNfgBCbgBDbwBU jABIdgBOgABDbn+YomagxX+XoABWjBFspQBKewBViwBDcABQg7/BuLvV5d/Vw+/gygBMfwBHdkBy jwBVjjOBsgBPgc/Lvn+Yoc/LvwBHdCBhir/Cu3+XoQBXkQBUiSBgh0BuiQBBbH+ZozBpjH+ZpABc lo+ip7/BulWWvwBak0BrhSBjjU2LtEB2lY+hpn+Yo3+WoGCDlgBZkc/MvxBdjn+Vnt/Uwt/Uw5+r rK+2sY+go5+uryBYewBGdTBrjxBbi3CPnkBnfiBolABJeQBJeDBdec/JvJ+vsEBviwBRhCBTdK+0 r6+3swBFcRBLb1BzhgBalp+wsgBfnABgnwBemgBVjQBfnf///wBhoCwAAAAA9AFLAAAI/wD/CRxI sKDBgwgTKlzIsKHDhxAjSpxIsaLFixgzatzIsaPHjyBDihxJsqTJkyhTqlzJsqXLlzBjypxJs6bN mzhz6tzJs6fPn0CDCh1KtKjRo0iTKl3KtKlCf18E3lGwx98eBXcEfvFHcKtAf2DB7mnzdU9WgYG4 DqTjL9BArwkFzYnjL0/Ur2HBzikIdaACf2TZzNHLZmBeq2T/bT189x9bt2j9KSDY1qnly5hd9v03 V0EbBXH2KlarVa0/P21S+/En6B/YyQLbkP5H18/b2QXZ1P3Shq3o06lTF6Z892/UtHNSD4YMXDXr 0cFTtxZYe6BsfxIMJ87Mvbt3jn23Dv//pzsq3NJfG9/pW/f5P9kD07I9e95gaILlXTc+2Nc4ddEC zZXeQOuZh1t8/swXW10AAvbdgxBG6FBfeQAYYB6jdWWaeuy1kcceCw7kRx6COJjhQbqNd6F+T32x 1V0p4udPYZv9U+CJBo1YYmKy7fjVdhIGKSSE7MHmF1f1wdVcG3NlBZgEfcFnY197iFafhgb95Rpq wRlkFVjTXcnikk1CF51UVIoGHx1xOAnkkHDG6VSRBWmZpGmH/UbWVoJIKVt2bGUnJnp1cnUYdnxB tQeGOBoW1aFWHprdn44hCt8de9Dh2ptyduopUF9MR6GFnGFYn5YsRuaWiXnkIeVgeRn/iFCMBM2B YY38aarbZLQKFGONabk1KKxhRSVlWrpx+umyzNpkYngzDpQfsgPZOqCjmwpUYh5cQUlHcFU2WtB9 0rK3n5d3sVUYuQHGce2AYnoL7l5S/uNHVco2q+++LNnam3udfcbuHnHwtty7Y2632Ghn/fOXBFtF p6Judv3727l83YWpWcgpV1mq8AIWnSBbNfxwvRLQlS+/LLcskgSDxbHdVFVd1fAdftCVB2Qg/9Oq azz7zFW4A0HpYp4FyaVzY7iiW66usM4xHq4/L5YXHUQLZHRaBMkWtMtghy322GSXbfbZaKet9tps t+3223DHLffcdNettm7+kFouaVYf/xoWgAsjFPhoftdFh4oFtZEzWHkokF1Cd3wxl+GIE57Q4K4V HtoXDRukOF11KTCdl037eq9Yoi+UVl2Cg2X36x3h/XFurpdW+N+3HZh77rebSJAgVfltZNKg59k5 5gVh3jvjnWvLrfDNZ37uHcQeNrxBbIH1ePK1w+79RbKDaBDeubto/vm87d4632Cx4f77bHwB+sRh XeXianoZdAddcSjgvuRgsY36DqK8BMHPfYHAH6kEATr7fYFNjCPdfu7wvDjQwUUQTFBCiocxy33v gxSRne/2NsCFIE9D7NPdP0qkQamA7lwSeN65thKH7Qkke6M7YQnB0kF7aY9ALyzIHf+ydz0eEgR/ dOgczsDytcjEYTUC5J4KQUjFhOCNLeKTUQodokPblbAgq8li9pRFwR8OhFsdROMXUUiZ0mkLLAqD I0LwZ0Mj+iqACKkKowrCFtSAJXpdrKIgaeeP/TWNfF5sSCAHt8jarec0cXlNGys3GsB1zyAF7KH0 XAhJhDxyP3asVJsQsjobUudJcpTiIFdpRdfRsHOI9CBDGrnF9S3IPXO0Shub+A8JsCGHl1SlYdyI l7tch5J+mQMoawQWTXnSRabEW1a4FcU1spKV5DPkfmIZSGESsHuBZAujsLiQ62yPW3mIHiaDycZh 9hBKHyNnROzIQl4u5C+i+Yu7vHn/zX4iUjY1JGEiZ8nOAXbRkLCh5kLqmTsLtsGU7fzmbEIpxbMo dJ6bWZ06F1KVu6zua93sJwhjWRVnkgecPETf+SK6zloWJBDcCugmF0LR6oWuibRsI8YgJsliSsSO IT0IC7fXTH6KdJWxLOUdU9g7lnqzb36Lw9SIqdPEPS8ve1BRTofZu2pS9KR+q6osH/KXLPpwn9Y8 KhVjyZkWcnN5s9kq4W4nM3cy5KtS6U3w2pfWscJ1Dg37qgjzItagGqQqw1vM6MaqVkGyFW+FeesU jRrRxRzwf8EbzkUjOTuECCJ7lpxiAQ93wECAdiB0ud4dDpjJW0JUISy8oPmI6FSE/8AMdQSCoAUb dtu68OxZ1husP9rUwn+kRZONDQpbfbgXyXKxoAM9KF2cKc+EmFORfxxoS8Xa0scNRm+EFCve7Bmg 5BzpdmY1bIV+Kb/JYKpgbZCfWXoZh7Ek8GObSVB0JHCH1LBFOKOZzqKSq5TlwtN9KJ0sCl8ryr6K 85aLzZEu8YLMRw5nMQxmC1pnahB4QuYvhVRIa/Fyvd/xVSB7LRwwFfwVnilgL4EqmgXtNcoVpYqY V6oaLglslOVWSmoJdgje8lWVKG71kdVMWk//0dGEnHjIeeykTxFCz1Qi5HncXU2NsTfcgTC0IPBs jGH3cJVAbO+JYHTXjPlzFxzjpv9E8jMpj3vMTkNmr69CzN/4QinXMR6kjIgSSBg9m90p5Q1FFMWr XQM03I1ajbt4K/EKi1qaDRMEnXguGrH20BrJFMo1kr7xYbYnJg1vdM5A8fFcXcqQ7MmZPPxrmFxT 9tUYUvQ6r7bRZitVXF/FmrsS9DLjIrxqYMPqXAwc7jl7vWDtJuRxEmgDmWmT5JxtCT9tbvO3unQb /VEV1T9RtSETrFL0EWTcDiRW0AJ5HS1aRQH3wx0YURcINgQCNGA6dwPhDUAmJkqTTbZOWL71v+e1 e9Fa23e8rQzPfLHwLospNzTvuD2uxVhrGsxZw4iW3x4O6tvgpgkWRk5ykuOt5CX/txrJoVo4lO8i xWGJwypQvhiUlxxvuyj5ywunAJtjwRX4O5RUbb5zoc8c5Tz0+chpcRqUr6J4eZE5FrhV8qSX3NZC f0bKweIKpWOhKrQYOcsPw4aRuyIOtFjFLp6Rh7C7gmBfWIV8u56yPKziGUzPORagMvIEreLval+5 P3zOd68b/vCIT7ziF8/4xjv+8ZCPvOSVfnKlB0/wcPX5F5jOuC90neZg8fouGIdyV6yCFqDLAx30 Tnk6cH4PfljF5zXP+d3MvuqF9zn+tF5yV2yef7Tw/MjZgvsv+HwVi/NH8G8/9aZ7PXtdH3teyj7y XXD+iZ8HOv/oMHvrM476ez/6/6H8QPJVDN7m/jj65NfP/va7//3wjz/J9UH/+tv//vjPv/73z//+ +///ABiAAjiABFiABniACJiACriADNiADviAEBiBEjiBFFiBFniBGJiBGriBHNiBHsh/XBCCIjiC JFiCJniCKJiCKriCLNiCLviCMBiDMjiDNFiDNniDOJiDOriDPNiDPjiC/RCEQjiERFiERniESJiE SriETNiETviEUBiFUjiFVFiFVniFWJiFWriFXNiFXviFYBiGYjiGZFiGZniGaJiGariGbNiGbviG cBiHcjiHdFiHTpgPeJiHeriHfNiHfviHgBiIgjiIhFiIhniIiJiIiriIjNiIjv/4iJAYiZI4iZRY iZZ4iZiYiZq4iZzYiZ74iaAYiqIIiF1QiqZ4iqiYiqq4iqzYiq74irAYi7I4i7RYi7Z4i7iYi7q4 i7zYi774i8AYjMJ4ivtQjMZ4jMiYjMq4jMzYjM74jNAYjdI4jdRYjdZ4jdiYjdq4jdzYjd74jeAY juI4juRYjuZ4juiYjuq4juzYju74js0IBvI4j/RYj/Z4j/iYj/o4j2HQj/4YBvsYkPr4j/0okAZ5 kARZkAe5kAMJkAyJjwmpkAb5jwKZkA95kRjZkARZkRGZkRZpjx+5jxQZkBKZkSbJkBGZkiq5kizZ koBABmbgBZiACWZgBoAACC3/mZP/eJMwWZNkcJM6GZQreZM1iQljQJM2iZMpeZNMyZRCyZRkEJU1 aQY/CZRCuZMwKZNI+ZMu+ZJTSZVW2Y9NKZVfWZVXeZZouZReaZRjMAZeAJYqyZNf6ZNOqZNe6QVt eZRgqZRySZdKqZY9WZV/uZNyKZhpeZhnGZWKuZiM2ZiO+ZiQGZlSqQZeYAdpgAZokAZ24AVqMJee +ZmgOZWUOQZ2IAZ2QAicSZWSuZqsmZWWWQawqZmp+ZmUiZen6QWzGZpziZukaQe+eZu5qZufmZWE IAZoUAaZuZm6qZgxWZyYaZpv+ZW1SQi+KQbWaZpuqZo9KZxl2ZreKZk1WZlp/1AGV1CeZZAGqNmZ 3ZmVlSkGaZAG1umW0dmdU7mYzSkGZaAFV6AFZSAGqCmatmma6amb02kH8gmatdmWuKmey/mdDvqg EBqhrBmTdoAGVwAHW7AI53maCoqbHuqhY0AI1Pmb1umbhNCWI+qex8mfsqmd3nkAoPCgakAIFroF f5ChyGmaHIqipbmi5okGOuqbHfqheOmc+XkFi2Ce56mjecmjv5mXI4qanFmZaLAIfPAGf8APWoAG HMqbIiql4WkH5LkFOCoG8ombPaqfi8AP/AAH/HAFGwqieemlv/mbJ5qaEAqjD0qhZcAPfxAAgMoH GgqfT4qnZjAGxomk5XkFmf9JqMDppQfanDX6BlgKB1qgmfLpnFrAD4vAn/6ZotdpmtZ5mcgJn0E6 oqX5npjpqE0aonaKmz4pobK6ndxZq7Zqq8yACVUKA0zABOZQDHCwn1qgBZCABmtgrMeKmZCgBX2w qIvQCq1wBX1ArMs6rBcKC3zQAg5wBZAgBvN5qwfwCbdak7m6BlewDUxADStgDm+wBa2QpNM6rMza CltQDJcAqJfAB8FantNarGtwrMdarYuwBW8QAJIgCQFwCdvgAPAar/Kqn4tKrMMar2gADZgADZAA BwGQBD5QANJwCVsgrJBQrcMKpDMJDVqwBQEAAzAgCcXArciKBlpgpZdwsHj/gAcr0AIJCwtbigYk S60Tu6jSuqVigAlewAzjWpPhmrQxKQZaAAsBMAgkQALlMAguCwfvWp5asAYWK5NroAVw0AJMEADm 4ACw0ApwsK/EqqzyarKYQKOtELXBQALU4LKdCgn/qp+wcAkeGwDAaq2LAAewsAVn+6zQmg4OkLbB 2gcOy7iB2woLm6RDO6zVGrEmywxIy7Sa65lq0Lme+7mgG7qiO7qkW7qjWQd/EARncAYkoAeGIAei ELt/YApwYAq6oAu1awp/4Aa8Kwe+awiv6wazuwWi4AaPYAg3iwdBUAB/oAtpcA+mK7oHoA7RC7p4 WQZbwASrewY0oAd44Lty//AIovAGxnu8epAImnAGM3AIrisHvCu8W2AK/KAL8ouhf/AHcoAHm5C+ M0AJh0ANZ/AI7/sGxYulbgC+AvwHxZvA/EAM7qkLj3AI2vALKKAMh2AI4oulCuwG7aoLDmwHxGAK huABq4sDm+AGtHu7cHDAekACZ0ABMAwAnUAJiYAHKKy7lDq+91u8B4zAb2AK/emW1Qu60zvEnouX ISwHJXAC29sJObAJwPu64gsHdXCeZaALW/AIQQAAh0ADZ/C6wOu78Eu877sFdQCfaXAFbhAM2rC9 tgADwmu7WOwGhpAI6qsJiWAIbiAKx2sIejAI7fu6clAAXxzGjyDAvfsIcv/wutr7vhwsu7sLvigc xJxpxJYcvUSayZq8yZzcyZ78tlrwBrJACWeQCxQgApQQDOVwCLyAB+awAnJAtiuAB4NQAsGgCSWQ A8agDBYwAx7QynoQDDMwA8oACqcsDAUgB1tQBlLqyUR6AOvgzJlMCKE8CDNwBp9gCSLAAsbAAv2L CokwCsYwAwNABetQA2cAAUWAAzhAApowBeUgCytgAr67rpLwxyZAA8YACugMARVABTgwA4nAC6hw COUQDIeQCIngAdzsy6hA0JQwA1QrB/xAnnygB7lwBhFwDLigDiJAAkmACoMwCKo8CDCwDYxqoQEg AhBQC5MAAepwCHjgqwH/IAc0MAWWcA5n8A7vEAq+MAtWsM6ocLO8kATUgAoiPQgHfQgkQAkiMM40 IAnLXLTS/MzRXNW4iQlrsAgBkAgn8As9LQScYATGzMssQAKoIAntyg97KweD0AkjYAk4kAujMApm PQNTwAuyMAijMAV4jQd8wKhlAAuS4A6VEAULkALJUAKDIA0wEMvSUA6U8Ak7XQE/YAmHgAosYAHK kAs/8AnKMAMiMAqowNCjIAKWMMwsMAqaQAneLNrvTAIDfQgGHQwPzQvB0NBJoMxlsAZGi9XAHdzC PdxVDcpvoAcicAYVgAg80AhnYAu/8AMUcM2kfc0iAAqN0Ai2oNyqwAmc/7C6F0ABluDcvXAG1QAM iNAIAADYWtDMWA3Nwk0IV3AJ1nwGiLAO69AI330GnMAD6kAEnFAJ3+0IkbC971ABZzAPZ9AJyT0D msC/IoAD4vDcO13gq3vgZwAKllADlbDd84AI6mAN3r26RAAKPFDelXAGPnAJgesGqODcq+sIQ9Dh Z4ACnwAKy3AC210AsJCfWyAL6/AAOtAAD7AAn5DcaD0Kyh0K23sGpYABk7C9FSDe57DdtnAOoPAJ jfAL210BEHAG5S0MFL0GZ/reV43VukrY12wFoaAIoYANZxAKwBAJ+30Co6AH7hsAtDwKjaAKp4Dg 990IKc7fLmAJ6tAMAf9uCz4gB3AwpngABbMgA6VAD6Fw5AAgDJktw4igCGcQ5WcQCaeQ3oM+CZmw upWACJ+wDI3wCadQ3uXt519e3o2ACEWQ4aBQAYNuBOrwCSK+vVUQAPyABu5N3MTdqsZ+7Mie7Mq+ 7MXJD3KQCKBwBghQCDFQCy8gAw9QDYwA6AmA4IwQCpFQCUuwAynACrUw7dXw4YwwDsiADEpwBqRQ CLMAAIPgBvxgpstu7AeACPlu7GLg7IdQ66HACIwQCQwgAzIwCUOwABzwACqADASADCpwBtGQCrGA AGfQDBnwA+ug3IiACMrNCNjACT/ACB+wA4VA8fF+DGdA8BNw8C9wBgv/fw21YACF8PKhgPEGEAs7 MAOGYKNyoAkIrgIqkAoP8A2OgPE7oAjDwAkX4AHSYMYrrAkZcAbsYA9n0AQLgAvKnQAgjwCxEA1n QPQqwA3eYAOkwAET8O2TEAMLEAOToAiKEAm9QAQpEAUPEAKpEAVEMAh/EMT93qT7HvhQirp6cAFn oAiFsPhVjwCOkAkcgPBnQASpvAIrQAOU8AqzwAoLgPFynwmZ8AKF8AAQEAoxbwMqEAG/kAhvwKZv sAlEMAmTIADhoPW4YA2zngC+EAmFQApn0ANAAAJnMA6FkAkCcAROMAkccAQycAbHEArDEAmKYABn AAKk0AQaEAuTEAIq/+AEILAAH9DyjMAA37AAMZ8BimDuNj8P4qAHb1AH+E748j//9F//+U6daQAH cnAI6gAQZxAU4tCAFKkntQohOFNIEcMFhSINYxSKka9IsQpdi6TIUYduZ0QiczQLgB43/MSMYdnS 5cuWBxDBpPlSDL8AiXKdCdUzEqtCjjJdi9XhzAMd8YAgO6MhVSyGjHAhSnDmmKJCAguB+1ZxAdam qRaeUaRoEoFSKgR8c4RBgEaOC45MmtQghjo9f/7kLNLQ0bgzBg7WilCI1SxQh+TAqWNKDqVm3jZs OKOj1AKBijAjSBXtzMFSbknFwtBxyJkjsY5ojeSrYqEQZwQ8SXHoTf+dlTV1y9Rdk1CdP3oukC1U nKGBWJkwFO+V7BUAkWdEgJrFagHEBcqLZwL6ZJIAAQ/OaHIDh19wUDKeNJh0ZpyiYZG+YsgUS8WZ DUCynC0lgNtB/1JJJTNW5COFLg6UWEoe2aSoB6ozFojiDBBiIeWBagqhTyNfnBkkpdx6E3FE3cQw 8UQUU1RxRRZbdHENNMr4QxZK1tGKAw5UUIGbWhxhKBVHNDjDEYl8QeSUU1SRb4ECFzDgDCluQOcM kkzSIwA40HCRxWlw2XJFNOCQ45CdgGGEkYki4q4UIDboISQn7tPAEUeOOQMRRNZBRKBSBtSglEw4 +OorRZpyZAE7NTv/ixRkBAihrUwKYVK+VOrpgIMzLkjEDTfkGGSGM4BRZIemdCTMsEYsSWSxRd6Q hYJKHgCvG29IcaSpUkrBVchSiGQlk0PpW+A0J1JpIrAFIlHlSEVSIUCHSXqhRA5+tPwyxS6vRXGN K97QY4AzMljg0BiGLES5BZJNhgJKEhkkEUooaGSYhyJUBN3sWHHkiXYm0+CDabcwJbhXmlXBiTMi YDKTXN1KCz/9zngCUAzoVI5OAuUrxdIGzugAmSyUgPaBVLA7KxUVHniUPkk7XNUUa7WVeWaaa6YZ xm5hoGQnK4DBZhIDXqilGkUmHEKGaiJkpJFlKLCEAgAawVOVRhjJ/+AMG+rRYUhgGgHAkDcWiVnm bGlGA6dEQD0lz0aSOXIWVRTBwAYVQDjjhQUqgSCUFCo4gwLAX/mlGUfKRYDJSSpgRIgaEOFkCUX6 PuMURibI5AWGEAjFl1mmbgSXDGIgpZRKztHjjT/eMISGM0DRsxcGZCh3B0asceYQSf644oo/DKni jB2Ke/KYBTAs3CpEz0ghBUao9hwXs5bDoBZFcGGaglfWmWCcVCLgRJMAxK65bJnX0GILSSjRphJs ZBiGkwmAOaWRZRHxWpNBDJHDkEE0ccZtv62NfniiHyNkcAYCkEIGydiUKeDwBzzYQggyOEK5hqAI CNRCBgh4QCbGRf+hHQVGEa1BEtwod4YKIEIVswDdE3T0gAakogFxCkctFvCBM5yJAeDYYLiAsUI8 LaMTskjJ2Gx2RDGsQYlLZGITnfhEKEZRitmARCsCEASRGOETn+CBEUQyjx98Yh1ePEMlzrAOUHQC AINgYwGEMYpRAKATlkBEJERSi8l9ohMFCMAWxCZFKE6DEYB0IhWtSI3o5EIEahzFIkcwxuj44hTr OIdIcgEuXsiif8MpIwoRwYNGiMQWLrAECiy5E0tYogah5IQR1mEJOYpABHJUZXR+kQNJ8GELWwgA E86ACk2IoAi/OAMnVPFKAAhDEm9ohRb6wEt8aMMSW1xHJYxwCmz/iMSMFVjHOk4gElDEMo5z/IQQ zFgJIXyCAsIAAC9QIYJvFvMCgwgbGgjpREHek4mGDMAgLEDML/LAEosEAByFUQA8SOISb7iEJGTB ThGAiwIEbaQaLbEObJjxDCegJxxawQd4QCE6Z2jGJH+g0V7M4oTRGQYi9AgAEYxCjbI8wwBmOcca cEKbOwCGRiexhHWgEhQVYGUzkNmJmAIgCAEoxiIgoU+oQjUNU6VqVa16VaxmVatbjRE/VLeCJBwi EYk4BCVy4AERaOIQh6CABSzwCgocYhOeMMQj7PoIQ+RVD5tIxC1A4QIXqEMdt0iEJx6xBX7UAQ1b zSoSyMFYrBLj/wpbeIQe1poIPeiBrp7YxCbYioMBwPUWa51CCeRqWDfgNRE5mMErXiGCW1BCBB6Y gVrJ6gHTjnWvmqCEB3IQ101kFg+G8MRuKTADC9xCD6IwDz+2IIpH7M8Th7hFCURAiUNoVg5/YEwZ ynCeRxS3s2SlLgVAC7jRHkITJQjGWOdK3MzCSwQzgC1m8SCH6E7XAsqI62EVC9mrOhbAViVGHSi7 CUpYYAA4oIAm5uoJuhoCD48QxRbMA4fnEpezmC2uHvSaWbZSQBkeSMRhdwcHN+jhFjMILQVGewsK LBiusn0FaN/q4ODq1RN48ASH+epZEb81cBZwAVzFitlN3EIEJf/IgQjkKty8HpYxxBhwlauMBixn Wctb5nKXvfxlMENCC1eARafkcOYAyAEPa77vmfGQ2UHoQQ4BcIMud8kHPL/BDQEIgCTexUY9SILO fFjEFbQACTAnWtFbFjMc+JDmM3NqoZfYs5ozqwdZtDmhc3bDFmDBhzfIQRZ6iHNC2cxmOUhizWeW Q6VP3WpOvUHPrtbDmt0Ai91dYRGfxnOnXu2GN/ABDoYuw5gdLetLUDrNkiB1nGt9ZlW3OQCT5pSa T03nYG+BD75+NqEPvWhwJ1rMi3g0Hv4si1YzNNh49iOxjc2HZO/ZDZSus56VfW1va4HcATB3qSVh aTaWut+A5jT/sLc9aTrvmc+WvvSo4YxuPu852qvmlMHxPOxvh1vjivZuxz3+cZCHXOQjJ3mx63AF R6fuD3jmQ+pkzfJZA/sPFm4uP/gBB5xjeAt/4FTCZ26e3WlBCyUnetG9O+abt3zlu8y5tkEda9S1 XNZLt3nSY446Wes561lfuZ1BnXVd5lznUpc5Yq9w8t3ZHMNff7mF+RF0oae96jfXduoqPnW2L13s dee6sJuLYZcHG+NDN3rhR450UPM5ANkWO87fbui4oxznTMdw4wEP9mHn+oEKlznZoa7niGeb5o1n utNdDvW7i36XgWe82B8vdMPHXvazpz3JtYB2m+da97ufe67r/yD029dB+Gi/gtpzv7vfw772sRc6 8Xcv/Fz3XvePP/vt5X784s9d+ryn/vCJr/3qA//21k+77oUvfuCfP/jR3372zQ/96/se/r1P/vJn b33jP9776kd/8NEO/f3DveNLPqTLOezTvqpzvO4LQOSbPgSsut1jP/nzPuCzv+XrPwzMQA3cQA7U wD7ogw4Mwf77wA8UQRM8QRQUuhIUwRUEPhJ8wRZEwRdMQRqMQRUEwQ3EwQy0QRrsQfSDQR/sQB50 JiB0QR0kQhJMwRgcwiBswhOMQCiMQimcQiqsQiu8QizMQi3cQi7sQi/8QjAMQzEcQzIsQzM8QzTk wgdcQzZsQ2Y3fEM4jEM5nEM6rEM7vEM8zEM93EM+7EM//ENADERB5MNdKkRDPERETERFXERGbERH fERIjERJnERKrERLvERMzERN3ERO7ERP/ERQDMVDHERSLEVTPEVUTEVVXEVWbEVXfEUEDAgAOw== ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif R0lGODlhBQAKAPcAAAAAAIAAAACAAICAAAAAgIAAgACAgMDAwMDcwKbK8EAgAGAgAIAgAKAgAMAg AOAgAABAACBAAEBAAGBAAIBAAKBAAMBAAOBAAABgACBgAEBgAGBgAIBgAKBgAMBgAOBgAACAACCA AECAAGCAAICAAKCAAMCAAOCAAACgACCgAECgAGCgAICgAKCgAMCgAOCgAADAACDAAEDAAGDAAIDA AKDAAMDAAODAAADgACDgAEDgAGDgAIDgAKDgAMDgAODgAAAAQCAAQEAAQGAAQIAAQKAAQMAAQOAA QAAgQCAgQEAgQGAgQIAgQKAgQMAgQOAgQABAQCBAQEBAQGBAQIBAQKBAQMBAQOBAQABgQCBgQEBg QGBgQIBgQKBgQMBgQOBgQACAQCCAQECAQGCAQICAQKCAQMCAQOCAQACgQCCgQECgQGCgQICgQKCg QMCgQOCgQADAQCDAQEDAQGDAQIDAQKDAQMDAQODAQADgQCDgQEDgQGDgQIDgQKDgQMDgQODgQAAA gCAAgEAAgGAAgIAAgKAAgMAAgOAAgAAggCAggEAggGAggIAggKAggMAggOAggABAgCBAgEBAgGBA gIBAgKBAgMBAgOBAgABggCBggEBggGBggIBggKBggMBggOBggACAgCCAgECAgGCAgICAgKCAgMCA gOCAgACggCCggECggGCggICggKCggMCggOCggADAgCDAgEDAgGDAgIDAgKDAgMDAgODAgADggCDg gEDggGDggIDggKDggMDggODggAAAwCAAwEAAwGAAwIAAwKAAwMAAwOAAwAAgwCAgwEAgwGAgwIAg wKAgwMAgwOAgwABAwCBAwEBAwGBAwIBAwKBAwMBAwOBAwABgwCBgwEBgwGBgwIBgwKBgwMBgwOBg wACAwCCAwECAwGCAwICAwKCAwMCAwOCAwACgwCCgwECgwGCgwICgwKCgwMCgwOCgwADAwCDAwEDA wGDAwIDAwKDAwP/78KCgpICAgP8AAAD/AP//AAAA//8A/wD//////yH5BAEAAP8ALAAAAAAFAAoA QAgVAP8JFAipoMGDCBEOJJiwIaSF/wICADs= ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/corrauth.gif R0lGODdhBwAJAPcAAAAAAIAAAACAAICAAAAAgIAAgACAgMDAwMDcwKbK8EAgAGAgAIAgAKAgAMAg AOAgAABAACBAAEBAAGBAAIBAAKBAAMBAAOBAAABgACBgAEBgAGBgAIBgAKBgAMBgAOBgAACAACCA AECAAGCAAICAAKCAAMCAAOCAAACgACCgAECgAGCgAICgAKCgAMCgAOCgAADAACDAAEDAAGDAAIDA AKDAAMDAAODAAADgACDgAEDgAGDgAIDgAKDgAMDgAODgAAAAQCAAQEAAQGAAQIAAQKAAQMAAQOAA QAAgQCAgQEAgQGAgQIAgQKAgQMAgQOAgQABAQCBAQEBAQGBAQIBAQKBAQMBAQOBAQABgQCBgQEBg QGBgQIBgQKBgQMBgQOBgQACAQCCAQECAQGCAQICAQKCAQMCAQOCAQACgQCCgQECgQGCgQICgQKCg QMCgQOCgQADAQCDAQEDAQGDAQIDAQKDAQMDAQODAQADgQCDgQEDgQGDgQIDgQKDgQMDgQODgQAAA gCAAgEAAgGAAgIAAgKAAgMAAgOAAgAAggCAggEAggGAggIAggKAggMAggOAggABAgCBAgEBAgGBA gIBAgKBAgMBAgOBAgABggCBggEBggGBggIBggKBggMBggOBggACAgCCAgECAgGCAgICAgKCAgMCA gOCAgACggCCggECggGCggICggKCggMCggOCggADAgCDAgEDAgGDAgIDAgKDAgMDAgODAgADggCDg gEDggGDggIDggKDggMDggODggAAAwCAAwEAAwGAAwIAAwKAAwMAAwOAAwAAgwCAgwEAgwGAgwIAg wKAgwMAgwOAgwABAwCBAwEBAwGBAwIBAwKBAwMBAwOBAwABgwCBgwEBgwGBgwIBgwKBgwMBgwOBg wACAwCCAwECAwGCAwICAwKCAwMCAwOCAwACgwCCgwECgwGCgwICgwKCgwMCgwOCgwADAwCDAwEDA wGDAwIDAwKDAwP/78KCgpICAgP8AAAD/AP//AAAA//8A/wD//////yH5BAAAAAAALAAAAAAHAAkA QAgoACGRGjgQkkCCpAT++8dv4cB/kCD+exgxYsGFEB9KnEhqYUSOHzMGBAA7 ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2615149&blobname=jkns-44-405-g001.gif R0lGODlhZABlAPf/AAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///yH5BAAAAAAALAAAAABkAGUA AAj+AAEIHEhQYAEEQOY8slOkhosTM66wmZJCxAwgXPBwwlQkQsGPAjmZAknSgcUTDhAUWOmgQgUE FRykqLihAMmbN1P8YTPjhIgNESr4nIGHywYPDiLM8OHjCihMOmzi5AQK50AHHmKqBIBgQ4UCLQ2y THoihQOrVhH4uMTFhQgPG2pcecI0RQURYuak2aLDZwodV/5McSAVJKaqOAt48BBhJcyEfw5tIXxi SxozSmpyrcC4MFqCCLZEegKkRg0dQMSwsYPnjxkdPuwECsSGSxEXKU6YPoTHI0mROBHAdeBAhxlQ uzAd4uRql50Tj/78CUSVS42zMF0g+AxayaXTLmb+iJnC5Y+dOYEW4fHh4gqeQ5iVpLGeYoYONnjO gqR6s4DXoFc8Aso1lxwSyCOYYLILHr5EgsccdvxxiSpzoASASZ5ZVcAUYtRQH3ls1JbebIGkoYMS dhwSSSBKsFEiUzWUdsgc+hXEH0gFiEDYBmzs8sghuxj4x4N4qILHM67oBYopoCzyiC1ieADWV58V UMQhLpTGxRytzbEFHo9cEt0cTzyRYiSPmIHHIlxsscUTMyihwyNTbGcjYgUp9pIIhyB4CR62HBKi GXZwoowp6rFhBiam2GFGLLFgkoaUEXjwmQuBAFHECalZFoheYV4SySJ/iLEFeo+seMghXJhhxnj+ KUzhwyI+fARcnkARNgepdvRqiipsXLYIcq4I6iqXYkxoxyOqiJHSURkW5MEiRQAhQg2vejrHH2Ee 8scigYghm4qRlFuiomKY0ZMSRahywp0ErYQUAg4AoQomkZgymyqgpKEat66owpsdbBySBhumHHJe IKBEhYAIvoGEwB+2uaAEhHiwMWRkYnqJn2rncSsmuHiIgUcaUxSRwhNcHFIBQYwWJFRKNXDiZCzD zPinGbsuEokqnKxKW4l/YHJJ0HPscokHKokQrUBPgOIDnBHOprGTkeAbLIRigPwHmpeQil/J5wFx xZVcFHajQAjMkJQImDyyCBtOzk1wGpGAwgn+J748xckldqTRKx4MszGHKZj0lpLTHzngyhRzpMAa foH8gd4lmEeiaK9cALGFdGFGYiB62wZysgtSx7LBQLcKdEJWDvzI5WqAC67Xgam6EsuPJQp+3qhm rLjrFDr+lOcVptQwQxHSpSF4a0UbvVBedmzBRYhnRkf4bNJF+MQcBacdEp4R1IBAaJqDHyx1eJw3 xyGiRsKcKossAj7BbDxyP/WRiCACAjUoCAJsUaEaoCcQCkNgny4hvU8RLg3TqVyYHlGi8yiKZ3YQ wwwOAQRMvAwAravBCRSjNMNV7mS0eVAatnUIn8kPFAuB0Bzm4Kr5mOFgkZjCu1JgqYGIYBj+SlhZ ZFrTwtBhTlQGqhyEsFYu0Z0nQjsxHE/aooorjI9tPniJmgLXKgjtBA+tOU9r0vMjA7EGfLQJ1mVe FQhMIKUCNSiMGBqmAwha7j0+w5zR8IWmRaShCCZTkZhSVb/6JdEOXFheCubACZvcSClduYQaA8cG GKrnhDMcoiHN86AQcekPzvOXHWzhAqTowDcR8MUc2POl2fQKfkc8Yrko5oPyqMho5XIS7x60BfBo yhgeudFDEPAETJhni3QzI5jM4yJOpOoStOlVr0B5ma6JIQ2X6IYZfIAAuwhkC7uYwgxqkJcHcalP odOlqMLlAi7MJmuRENUjxiQGLlzhCjr+EOG1bDGDAgAHAUWgWSwyFqIHuW9X0Fxfgmx2vyEts2ul A4UytsEJIHTlXQPEgw48oKYZTi4yeURTqFiVEHLFb57qeWLgmKKDcXIiDQU4DABwc77A1I+MGTPD apADClCmSDk7ORjvLLiIS+hNQNHYRRxlAoATRGMLnNrebHijpkDEU0yiKtB41lSuzIl0EasyEBuu gJk4zSEWDhAJAk5ZgBMQTCPQtOpOPukKV9jPRTAsmfNaGIheFexkrsLEMEwxhxl0EwFmcMUTKmCG 6YAVpVPVYzxzKQYUpWqyhDRk5UQZuJZOYRg1A0UEUrAdiZhnWwSbTvvUcxhJroZ+c0j+Fx7w1de7 caFVdgDFmhZhvp8Mgw0bdZEC6zfPJsIzq5FY5bLiOc/myi1jEN0YVIGgL1CAwgUbQEAEHAU+51nu YKyJUCRc0dM0MGxGOj3EvR50zGseAhSOWtMIEeCCXTzhBC4IVoTAijuRerWJf7iCQua5qubeFIxD itDJdDMHY8RCFTo4nwgAd0Geic2veLiELWJRojUNiVCRsEWgZgi+9ybOeSEqwkFm8AcleIB57mvN e+QJtj6iKRBcSIOKtKfL5oa1cqbjwkyuEI1nxEI7BcAWBMNqnkcYDkKFcrD9uCW2QJhiGL6wXMjc d5lgsUEMKvHAFDb6hOmEtYVMfOb+j0LHqmXNU4IilZu3zHOZLQTxBFNQxTZUdz4npQGMn1zh88Ao WH39ORB/KpgqjJGzbdnuVdbkwiLscD4HBBEvgF5Tqp5Zrk2TC1zlcSGcDQlWgkLxDxtVwh+64QqV REB/UhRj4J4nHVMcCpStKZB5kROo1dxPL1dThSoC0ZgN1eee+3WhV+vX6SZK5lvmGjBx1fNJGpoh kR5QAhe2oYqU6GRcljMcGFdIuEPYwhicCATPiiYoK+9iGJGwIPZ+5K+upWF1CLhCClzgA8iN0bEM dG78kOjOTYOukDdF4Mm2MIUtAMEDs+K2Sq7gC1dQ88mXcR56/hALfellhj2l25X+nxEJOqvmU2q6 6SXm+wQP1GBsCJ5OqJodN6tCU9JNLKRzyzik+eBnChC3RTRM0Rgg/ImCQO5riA5GuHTrRaffClaG Y7GLFd1NYyscVqQu4YICVCAzKdDYmRXI6auCtVwGs+oEUSq3ujFTXKYrwgaKoIxdmIIwOqDNwSTE iaz9CWPpyZjG0+MqjWFCFX/y69VVpO45uAAAGwDCBmLlOzCOUZCZkyeB06DstXsarKuKjOV8IILP 6k4lG5TOdFQRjW50A92mKzfBoluia7oobp3M+NVcI4Y/OA3PJ2CKHdMjHTw6KZbxVI87Jxs/NOWy bqUOnBJOwCDdNWYGG5m0laP+IY5yXMMX94rOkBRl3gfmuFc/YiaKIX1NLhVdyNoOrx3ACvoilguX 6Q/1Efk48LrR5gr2BFWPIBKx4DQpIDzvowrP4AvnpgzG4GBCw10Zox7OwxpT9XQH4yqq8WSNUQN2 4AEYAT4Ztg3icA3G8CvWhVXQBD29dyBXhTmXhXRzRkNFwAUnEAu55QopcBBilyp24ANFEDW+oAzR cA1VZzAz9CAKYzgOVTnoohcHswh1ZQpAABYu4C5X8DmYYAvdAA/+UA/X8Az5kA571lVJhAefY1Uh lXN4QCgt9GFuUgTdUAScoAqGFQFc0EeH4AOLIQJlolO7EA2xsBMkMn9ppFr+fQWF3bVC+HFdbSUC ygAEqaEKvvAMXugP/qAMkdAN/pAP3XBSpTYFCFQ5grRA7SOCgnI2z4EHwyACIjEDEYAA3oFI2PUT QPEWIPgMz/ApGLMrJZJJQzJDECQ3g3I1UqIDG8AJcyACZnAI6dB6+dCJxuAz4uCJ8xQ2H/YEYZQe aEI40TF/GbMtbPAEZuABtmAHaWUKiwEAKQAKmXEULuEVHiAC+xYLQwc+3/I+hOMgXEJDgjNpj9CG aWAKz2AG2uUCDnAFruABOeYK7bALtmB38oMJkBI26KR6LdNcTcQaMyIGfDU7adAU0VArVDFaBRAB CmMXFeAVLuEST0CQ26D+DETkZNKxhAdjOnkRCdfUPIfTTz6RI65QBDMAPpzwDNEwDJiAaKDgCmEj Z25nSxP0HqB0V7yhX/7SjpFQE1QhHCmhBD3lAhEQAUmxAT+BCUW2DddgCoyIHyESLDc0B5Gwa9X0 a26TAh7hAGwQCxXABarBJaZAURthV6TSJ04yI1swIvNkRzpGIn3VJjyhBNHwBNvxT11XAXNwGDAE lhvwOqbgC5dwZa7QhkSiFxlzTJIEJjc0RHaQAmQ5Qq5jJBtgPV5kC+VgC6CwgkOCJi1UMszUJ7FF MAeibjxzWy2lDIfQQ/80j23FMQ/GQxUATjZTOTvRe6GkdGGDB/DFiM7+swim4DSbGTEFcAVzKAJX kBdscAneN2Ib8yNrEghF8DyFKTjSaR7s0ksbAJG1ckUXUgMe8QTEZQpTsAHYFzfe4jx61TPJ9VpO Aj5cogorsoNKUWwG4QFzsA0QQY6r0UIKY3ktNEMGogREpDAEI2Ar5ChZeB2csA1mEDE3Ahbm4wBi UC6QEgkQaZFtOH8rFAiqcEyKUjQf92egoApOA0CM8REzsGgbkCUbiD1TZSDtYzpAkCLoFSxzYT18 qW8VYAfbgAem4RutgxUvOgWLYAvw0A27QCpgFCwSQjDv02Ui1SBO0kaY8HgFwEMYsToGwRVK8AzG UBEpUJ6lsyqneEL+6lIeBnUemMEUT0A8qCMObCIO4lAPTwBCeHKSFkEYNXAIiEJnirIastE+ZvAI 6YJ5izYMrmALeGAp9OUBfwB+4hBAA+F1YsB9fFgEV8AaOsWgUGQGrHkCtnpDrmIbSqAEM5ACh7AN 8IAJT+AK/sAGrgdCIzEQ2iUCPuARG9Ay0sQlJAMhWyACpbMx6fErafA/wqEyG9AOGgZ+H3GtygAP H9geUyCJU0BWZnAFSuADInQaJzIFw1otMRIJ0eCJf/AEGyB0iNYO/oQnbMMZRSAlkKcDJpMqHToR TiNmf4A0puI2FyICqPETFdAOmCAOvwISLwYK5eALQGcR7KIET9D+ECvTGpvCr/gaI4HgC+kAD4cy B3IHAE9gDP5gDIdAqR9xkhXgA3YpFUHhAuFxAmF5AhUQi0ChEizhAfZRrEfRGGxQcd0Aq40zA1yg Z9sACsRzF69DlqgBBKxpEVzACdEAD/lAUdUzZh8EADUgGAIhU0N7EB6QAg7RGGKxEo5hE4QhHC5w IqQnlhsAFAPhAlPwQXABF0exGB6gA1twnsMQDQITCJYxB22yBfdkMrZwDTGZMPNBF2UruYsRuaaw kJEbuYtRFidwAieiAy7gEEobu7ErAmWxPPzqISKgtLiBi4+buIuBicZ7vMibvMq7vMzbvM77vNDb vP4zvdRbvdb+q7u66xc1MAV2oGGDhQdP8BA+4RPXqwrRe77oi7zccRMOMAN2MAzp0A6QCqntUA/1 kA7Giaf7kb78e77cIRXC4TlWdg3XYAvhIiu2ugWq8ST14A/bwAZ+ayP9O8HOyx0RcAWGcg3DIEn3 miUteyL39Gdd8gfDkA/5YAr6yzoUvMLKqyERUAS78Ilb4AEHcwW46wGy66/4OgOFywZBEwjVWA6P 0EMhwcJGbLxWAQTRsA2IxAVPW6z4OgU39B6rkiKVgxpAiDlpYAwm/Adqc8RHfBMIIAbXAF8DG7su UARK0FeBV0SrAi7qdh5c4AOcR2T+8AwpoMJgzMI4ggB20A3+dtCyhYsRUURBhVlgfaJArAE9OuBO YpAO9TAHUsEJe8zHQzurlXUCIHpCDgImYDIqxLUiEZR+i/A3PvAmi5APuyACRVzJFDy0ZqAMssIp BdZH87cikwV9nwp6nTkMtvAHM2Ai3VAOU9DKrty/HzEF4nAFPVEDcXogxlTKYYN/o/Ij4OIzjGYM DQIfmsIJ9bAIk3nME1wQJ2AMbIAb5PEtf9NCy4IJf4MvqdJ3uLQIgsWUphAorVEDXKAE8OALlkLJ 4sy/8eIkfeGBYAWXlkQqRaM3oiISS5Igl1CjG/F6oCAZT6ADriAOJBnQAj0QOqCsM8CvvWdmVGEK f9NGTFL+0r8CNJjzjKbw0srQDvTzCDrAr/BgBiDE0el7FXagBPz2I2ZwIKKyJCb9I1RhXSttXX0X C2PoCr5QcZ6JaIC0Ac9wCf6k0+jr0ZHwYmZQVEJtXXojbPjy0mStCr9i0qrQDp1olM9gCoN0CVuw KYswDBEA0FgNvWwTNnV0fO5MFWZt1mcN2LcpEg69C9H4hcPQcWKSIOOhz91wAphw19ErEClgC2kA gG0UNMPiCm4NNCLBL0+BQBP00oaNie0QMKDQVZjAEBGgBOmAfZKN1w6wYa6CB+WyWi+tHCUXJnlE QWISGSbtkP6QDrbAJPx3CWkwFO1QM7H9vAAABM/QPqf+Yjpfszem8AjmdU6pYjRHYz9Lwgn22M9L 8hTyIyrPUbjtAAR23dzLWwDNsQWXIAabVodLshD5g2PdexjczQY/49a7UA7RQNTktRGZk0/8TIfs 3bwpILJbYNlGxSRNgjjcYlwLxd30nNvGINOB7dlPgdxF4AOSut4Jjrw68AzwIQ4asXXeshHvdDT4 okdZZdbOpDfWBdh11XFUwQZA4ALwoN4jvrzJiG4OuIDdwMQD6Bq7cksMtBHu/NKpzRsaQdS/8mAD /oM60A46IOI/jonPTYRewgWxUA/5UA5N8ilcwBp5o9RhzS83BSHMUeOu8DfxtNohnQ5ZvuXJCwAR sAj+ZlAEqFEEtoCJ4lAiKeMDQX3U/II4zldchydsv8LZin4Jc1ABbFAOMxDZeH68dHsIY6YDnm4G mJgPruC5TxAjl3kYTPIjWYUJhlQuR/0rfc0JXOAAmJAOLqDlWw4A9VRZ+eQDStDA8GAM3yM4lTvn l0BlfjfNfY3UQdp3mJMZmLANKYDrPw4A5TmO+aTPJmyb5blCu6LfoDOAS559GxFPqY05qf0HRVAB rvAMHoDpmc7lJ9BXpZFPtjCG0fBU5tUnqM4JEpLsBTJPjRVeTdZckeMAsWALaRXvSIyXv2w9lxCN +dAO+RBvulQ/VLE3qc3blYc1YzIHU2Aai7UB1xD+CVfN8P4AAAWgpekwDNfQwF/I1O1AKqTyPtfo duP4JX3SVQg0S7rrA8VRD2mQ0yiv8mlwDZ14vOIQC2KoDBDUK2QHRjNcAe77LW03WXETCW3ST2KQ 3kTP8OzoC4h2Dd6nNJgAD5dQLKV7aBmzBT5wEAhwAnkhpwwE0XKjs8IR7XlM7SOOAKqgiahBHkow BX+QDqx+DW04BcPOF9PHjijxPc/EQJhjIIKiA9b+1C/D9wleA+46x7AxNUEND7ZwBZHgCyczF+oO HiYRi+60QKKCS5hjFC6wCNuACWeh+eyNB/ngC6ZQBHYCAB5gB5Aa1OKwE3ZQLoFxStR3HcwzmKr+ Ljfz9G0ZjQfhjPK7UA/vJskDEQFzUA75cAnKAMjnsQjAMgzmqrT3NQVU/FhY45/8Eg31ID6439y+ 4A/iEA2YkKcnsAheqAzXEJAAYSbNI1e+2rULlMJDCi5/nnDhMmfRnz+P8DxMh8nXtnQ+AADg5E/k SJIlTZ5EmbKkq3zilJlCUOCjD1v18pUTd8gOHjaXjHXzl8/YFREnrqgChWcOJztp5rAxw8VWNFDd tnWbUaBASJVdvX4dGcgfPH+7KhSIcOKSTX/12qlKw2bgsG71QC1ycULHoVjXtm2Dt2tRpEt40qhS ZaxdvmEnPnIFG1nySDb5gpbDNAeTK8CWg+b+5GLmUDR4w2oA2XDi0KNLu8q9HrZI2Z+4gWItzndp w+PJvSM/aSfyWjd428o9w6PMcr1ukZqaieVvkY4ZEUKrwhTpjw5Qw6I5F7PFzjOR28RUAIAAsm/2 KIuI89fOlStbw2JhCnRoV7Rt0UIX2SKSfOzwwQMP2FBll2sWMQYUZcQZJo0/QvsDvm7MyIq39jY0 SQll2rLPlmcEO2SRS5TpZpc5rpiCC1CuKaKGtA6R6JAp5thlmHYeYcMOgQJJxx9bfHHJBZA4RHIk IEwUx6106ilnGwgxQQoPMYpQwgxTxGDDBQR8sGORNLB8Qgk8hsHDjjnSkJCsa3aJRRVljkzYEskN lODCDmXSISuodBZhg405plDCBSXCw+OREwrgYgqdfFAiUjNUec4MM9gwpp5rQnpyqzqRBMCBClJg IztlrolNiSt41KEGQ6fQwY5AKnAgUiC4uMKHW+24xFIuxOACD1uUwUQZUFRxhc5P2/so1C3YuGKO Q/6YooIaqPXBhRmAuCIFHZ5AIIIWi5jhkUO2uCKSRQKZ49cnFjFuC2EXcUDZZX1rtoIpuj3tigo2 aDGFLXwQww5OivDBhwpEuEJVF/C46ApMdtklDRaVqDAfPIxsdr17JwsIADs= ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2615149&blobname=jkns-44-405-g002.gif R0lGODlhZABkAPcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCsrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0NDU1NTY2 Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdHR0hISElJ SUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpaWltbW1xc XF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1tbW5ubm9v b3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CAgIGBgYKC goODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOTk5SUlJWV lZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaampqenp6io qKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5ubq6uru7 u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zMzM3Nzc7O zs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f3+Dg4OHh 4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy8vPz8/T0 9PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///wAAAAAAACH5BAAAAAAALAAAAABkAGQA AAj+ABcIHEiw4AIGDAoiRFhhRhM8dWqZkycPHsWLGDNq3FgRGp4WO8oAqTBwYUmDKAkCWMmypcuX LRngcDLDSzN5+3Lq3MlTZ76eQH2as4QESZMWC2AqXcq0KcsCO5BsQELsZ9Cg+eCBszYNmjh4Vq/6 bAYHC5YTBZyqXeuywIYuTpDYChu0ojhw04gR63osGDFXnUyNMnVs2kSxOfOB89Kky4a0bCMvLQCi CRJTOK/mMwfNlmdbu0yxKkyslmdWnz6ZMtVpVK1g1uCJzZdvlxMcMCTrflqgwAwnTqzNNmcN2jFb rmrtssUKNLRgu5IHs2WqlqtR2CWxCtZMm+yr8Aj+AUGyAPJutgVgzGCUGai8vHp3HatlypV9V7vk 76LPqjp9+6OkVl0wfk0DFlbT6NFFBeehZ9koV8kDTS2S2AKdaaOwUgsrrnBoynSDYcfKfs25Ygkr zXlWSy3HHKNNezzJIwkQjzXIVG9I4DENXTu185ctrW2YYnWsSCIaciGaYkknn2jHoSWq7VIifSva Yg6PiY2ywwfm2ejSAkBMUZV71kS3miv1rWaKJJIE2GYn/UnSIZqR1PlJYJ0ENhiHHdZniSnEtBPU MUCA0KWXAKS3QzNA5UNMfazs2R92llgSiSSdWDKKpqbYIklqg31iyKWYCiZYf6yZ8omJkaxqizj+ QFkzxQ6HNlgADkAwylM+4hyzGmqd1MKkJZguyQgjhjCC2ieWBNMhs3fWKQmxmxp757SfoKbpda4c A2NO4kQyxEq1RlZAC100w2M72uyn6moBVsoIm3Ua4kckfqgq6ichMpsnsp1EYgimhBjCb6Zr5pnt KEzu8t1O1hDSQrmRVdCErjvBEwyfm4ZKbCSMEBKJJYYQMm0kTN5ZaZOdtFmstMlKwgh2qbkiCSGV spbaiOb0NAocE+wGmUy1rPtXch1myGSebCYrssjTYhoga4TowYgfjESCHbJ+GNIym6qxpocfkoys 6ar8wrpTPqZ4QbFTC5xAyLrUaShapSfOS6z+H4QELIm9l1rCSJ4Z+uFHwNSKSggcXZu8JJOS4DHy p/ymZgkhpjycUzuWjJuoZCfgIGiPzVw3qb9LFrxk13WKPG/ZTfJrSdfMEvtJJHoQYvjAx7YsmB55 VgpntvgawgqP1vgBwudsgZBCMHS108yK9x1sSMlXZx3y9dMGtiSzmPrNZtZ/V1219sCvnN20UHIo iR4lE7PrKIYktVZvWBjCUzvOqja1pZGomiE+5gc8EOKABvvUplqTLNVkqk71Mpwf4DdAPDDCUnkC 2QVb9ic0paYTPdtJgtz2tpacqwwhBFeA7LOaTBHLUtcTGMjqhCzHdY9NLsSUzG43QTjUYYL+Jfub BA2HrJiJKkP64hdd4IEHQ8xgLQvwwvF8MgoL1u5aKAOZ4N5HCGRJomu5u572RqUarXHwb3hgAxv0 AAc9/DB3fMMDHFGmvakxiRF6mAZPiIEFPNivKTCQhOaawQgLao1miItEE50msIHB4YB41B0AdWiy egUQDhCpQx3SCIdH6o5v1yPj4xyohzLgwQ/gyBgaptAEtXghGD16X50CFK+yXUqDIJugIg1nQVCC 7FMDJAQPQ+YHNdZBjXBQoxyLyTc9/O1SD/wEAjdZB0I8LB/BwAEegsaUD0gCRsEg2b0ixaZKTYts BbNayQBXNUyGcoZ1cqY0D6iHsXUSDmX+KAMbTKkHPFjwkUxCmeCgRLPI4UF+OmkHHoBQhrcVoAys 2Ik8pOSvygVMYES0l8kmmE44oKFxukPW4JjWiQOioZ6b7MIUuoAFNLDBC3hgHN/61glG3K5S2MlT J+yFmZ1kUw8zqFVaNmAIPeoEHhuimb5GQUOBPQ2MVUMDXKbgBcYZwoBlwyCb4PdINaLBCyzFwhTK 0AU2bFJ3BZNZC4WnKaaZQjg60UYdYECIP7qkC11IpU7M4cEAMYkVd5Th9QyHUZYiwQlNGEIT1ki2 rGWKqYUsIB7IClYniBULLC1DJ+vgxlFlqqYts5NSWTG6fYiDFTCYAhJgsgA9oKE9tRn+BZpY40IB dfGqtx1VHRCr2sQqlg18q4NjL3e1yb5UrHjtQhlWWgaX4lOOuQscpkb1JyjlyRRG3Uc+yPIBPTDg UDjAQSTCAg9o0RaHrVlT2XxZsjIM4bCKbYJ8u3CvrsmsiHhAg35XilkvlAGsU3CpS2NaMkiWrXcM C1uGPvEwcHwCBk7wQlu8AANo7EQcojFdiBgmuA8WUmCFdG98m8BKo7ABxAW7qhvRgIXDlsEJY3XC cp2gXDTUAQ2Y7GcB+Sawi74wVNmVxzH8UAFCMOApDFDtIFkzGFW1Jl4P1F0YDcEGVsblsHGxjBPg 90OBsVGfcMEsjZmL1wCzwaMiM0T+G3ccsksxC2WjQE4w2mONWqBrB08ZAhAYQV5b1OJOjr1TpqIW QHWGDA9eQOwQhjCF9zYhTGygZz/T6AUslAGzeP0vS7vQBEvr15OGQANE4Mi3aYlUgaPQ6z7kQYy5 4uEpFD6GCCMVIlMHkV9fPGURD8hp+SJhCsCxTBNwjOMz75OsZYUDjbtQabzK2JRmPWUBN9nEJgrX XtoDlYV1UucTwOEDK/kAo9W2D43R8k9K+hfYrgZGvoWs18IGNhKGEOH86rMOy8VCp70A7Mw2e6Uw jWk1r7pGzmoypGLUVIZ2QW55NMMLQOhCWqYAglGUVhy2sJTKUvbZrNWzjQKc3Sr+HT0rIDTBCUPA wuK6oF9+sxSsLAX4WPHqBS9IuWuGo3Y/O1kwaHIoQKxQNa9MAQJCAIABaGgBNMJijWfdboYyuxRa r7o9AzKiDlgI0w6Ag3L51uETjKg5zadgaZUq1wtfnQIbsEDjA3L2alXjLFopaOrvZUvWe53GDroA gBkAgQ3k3seElMThZInxgLsbW8GqRjIv7MDRRsGBYusgOKn2l5VTJTtY+S1VZntccjjH2vW6KNJR BWhnwXhYOxaTggJg4QMS8QkxBvNCS3URa/ArWAHxlWJHGoXeV0asE/BFVuDwG9PLZjbbzbJSPFyu n/U8cdZKBs95EQ5Otth2ucH+0YkTLKALKbBGe+SR8ex84l4my9rIqubPrKV4XnAwORK2/miTY0GR ZAU2G2gsY7yaJf9TEIBsMCrwc0qGYDXFwj4DMzJZwymuoH3vMQ1DcAJUlUKmlRx+9TehNDDT9UlY RQgWZAicBhwmd2WMdlXLpVL9lVyshGwBaFkhyDdEZDUPNDhswjAB1Tf1oS46QQwPBwQt0AmltQ/T YAuyxTBZRC/DVVOhVENXw0onZxTBhliixmLKtWn8BVbLxWJs1wRlYCm5U0/zoje3dEGlcjtTQxhh EQzHYAhlkALEAFu2sComIjxnKCCsglZ+8HZ+kGiH9XswxkpeUAcuVwa/BnP+zKZp/DYeajcqWHNA cvRM2dMqiSQYsvUaYTEhrFAHi9Ie7bALT7YykUItlvIy7AdKhFAHwGZZ8/ZeWzdWX1VzMGdZL5Zo VMVp84YEZQBJ/VRNt3VJNpVgARMnsjVnOiEOtTAKAQYND6MN02MKcFY57zMqJYNrhmM+ulMWuQhs 8kViY7VPmIVc/AZsZuEEaAAcSIAFaAcyildIJmNqeiA8YfMpqMEhU5QYx+AKO8AI4EBn0QFY2LEp fzM2IWh7zQRdILhKJJZoZYYFbCBHhGhpYFVl8gVzhogEQABji9Q4ROR+mzQqByRMlpgtG6I51sAK M+AK7ZCJ1AEnKHI5E4T+BrpjagGUTmOzh3UAB/32UmjwX801QW7UXG7kBz5UVTnZBTswHr9VTTVU T2RjCZlkQHJEU5FyKqagavtgDaZQYSupE32xIXSSLEwzQLa2UzNVQPX0X2hAMvmUTF3wSAi4TD8k RyFzde9VFEXhBZJFNjNFk7lDPt4zGHCSIYE3DbvQAtNAbvkwH8k4aAqTGjOTGk1iSzrmlGtkMJ2Q kzH1kLrDBjJDjeoXQIwAB0bxa7/WBQeYRlfzS0uCL9YHJaLRH3ESCXCVE9pADEhgDaomD88SMoQz NQLJMuYUknIkTq1CNWOTnLnDBieiKeEDdrojEolVFDT2UYZQBwWGMxf+ZClQckEi2Rr+0gnZZVrQ gAXasJsbQ1unpySk2DIP9EwoNUDXNQoyEzADIziAAyB6AlgBQ5GNcWmWlk4D41krQ5Z4hE9y1yZx Np7iAA1dwBU6QX71QUuSuSkWlSlt9jGkNzOUMjtPUzaYgjUasiqyxWSdUBbKpUZbiJ16uFOB1SaR QIjKBT+WYB0sshPEgQfNUJv5gBws9ELpllVdtDqkcoMkAzkjc0tLgoMHJDXldCoCI4ibxG/6JG1p VVLac0HH0jWmx0KjAEsJpQ2GsAu1yWrMgSKExySm0IQhcznBYyneeSmv8zeVEgnasjSOeZzgUwbD VkAsBmNYwJTHEjL+8IMytwMqlrieeAcu09AsigkioiEY15FuTlUyZKNTmNIkxNI9iLNDtOcvn6Ik knlLhLBKVLVSZNcYdVlNkkMq1lU7S8IptaB9+yA9jGAlPhEdATJS3bOpx1IyPjQ4OFgnpwSCk+Oe A7Qm4JOpbTKZsySCAaiOKsVKU+CUIjVSH4MsSdoqqqENPUIMhhAMKbRduvpCZ1ROi2MWNscvXdRF IGMvXtOADEOfmKkw8zIYAhUvhCiA+5dYnbZ4x2Iy7dquF7QmqqKSpAMHxBB4zeBnrEEyn4IpEMSn OeI1DPM+XeM3XcQmz/mYovFBkSAYTAhYl9NcaOCFAfh7LRVGWCP+enXyWHuSLZpjDtqABYEiQsRQ lZHyQSDKaUNgSnpjL84ENq3xWcwyiqEiGPwSkNUiWxk0WVL1e0ahWrroTAXmZgeDGh9rCzAiDtrg BdBggdowhyiiGiT7dCr1EIdje/CDLZJ5J8wiIlDmJvLyWS3zQZaAdWWlWjC2aIkVYb03MtixGsmY IaZBF10BB8cwhOYgLGgiW7TGLLsFY83QDtZAP9yTMi4zPOkVkJaoMxyrcdVle13AaHDAb4jVBJKX ctXkTIFRHwsTkBwSFvkADbtACMdwJUdVN1VZordjhYywOauJqTM0QJaDbk3WL+/CCkkaNYLjB42G BF6wJEXhr1T+6JRGErv+0ykIlRPw0AyGAAS1MA3jFwzWgSYAiSfj6AcTEQxNBKsgiifNujQ5ZSRo Ohi78DeDWi+M0AVAsANeUCeNBgSONgT05QdLkqkZVh34Qauc0QUMIAmJKXt9Uh1p0jKX5QRrRFb3 ojXKmimSyTSfYjuDk4yXYzwHBmK7xKcmd2lwMR7B90jz0kUII6mvMZ7acAwwkAJw0B0iRB3niyK7 +l98K4hZQ6HJ2xp4Qy/SEiCpyAaDQyyGJzkHRJoEnI5OQMABOF9NdI1SM5j4kbs4KgkMwGw7uhPg sCErQh9KSwguLF8wVgZ+oBqxKjuCxlRyKnWtEmqa1Sq5VCf+oLSHXvCHvzdfi4YF9SQysYOmGtIt MAIPZQAAhoAEx2AN5DUd/ZFUZXOdeHVYmFUGBkOypyczt2c1ZihSo+AH+gQHbGJDs3M98MMI5/he i6Znf9gFTVQnlSIkpoEctKoYufEJSFAL2hB404EckBIwVWyLADdODxRQoyZAJlMHMvMphKBGM0Nb NTWo77NVEKdYGGnAMIZjPYcpO9sfoGGB5mALAgG9EjyehmkaKOIKdBwyysZsNdc3u3A5NHwzCETD AjQyeZIslsAqZaMHEMTPl8IGiuW3nZaOJ5UsKBMY9qEatsCDiWENhgAALTAECjINO5JQxGC+SVM5 TeLG/gb+B1pKygdzO5/lmq1CUCujJE1UinBXMMiCB8GmZ51mjv50KYLRJhyCHLWgOUImcVjAAJ2A A28FIw2rHP/YIYB1LGXhXy7FnMEAje/CMEqiextELVpLnxZUNi5ELEuDB/76t0iAy6V2KtehHYKB 0TkxDcfQAt4GAIiGB9YQeOKwHxsyofwCr9noBWcGP51LPNESStMyMJ9gHS3UJBLNPq5qCWxAnTAW xwgNNq7RHx5EWmsDrhXA0AAAA5GwA8FAvhHaGRrCu0xFMoN1Zj+kMEvq0p+JQy9bIRgSddSoKXDa NI2GcvD1lq06LZEqJKPBE+BgGxsgCUFTAJKwA4Sw1zj+mo/M4aPVsoAzZUDcWVP78q6+OqSR4ArM sSmXMiq/hDUCVdmJtcVTQFgMA1jz7Ne2oDnYNAofYI5pUQC4PASVTLt/cSSigSejF5p6A7ccWywL dC9m2NiqArHHcqSlWEBkx42H9ZBwYLFxmyYrsqjg0gxdMAGMsDyJUgGWAAOM8CIZsx8dYoRI9HQb C03EoioCzZ0aZN6GuiyKg9M2uU/ouMVOQG04EymDaRorEodrk9wgkCNdYgg7AAMLyxMYRz2yqayr GTh+dbHXYnvaWpepgRyaus2kF1Mjh3LAFmBnBWcisiIEsgtYuWqLUQGG0AImBARGFgnMyBNNx8ai 0WT++HlfcQstAuXaN7O/S8IKUDJDypyKN/ZVRrF8U+BRjzQyqjLUtjDS0PAt8GAKC9AEjHAoBeAH MDAE3aE5gucsk24q8mJLsKlAA1NT9LLJG2Q8L+R+5MNGrjXIAKdcMVVJeJKM6Jx6MXIMMzABkhBU JgQVelABeOAVPYFhZqueflNEtpQp11NTI2PggzM4rMA9NyN6Uklpm2ZKbZQsXjQvgrEf4ror4IAF BYAEaFAuBaAHO3ACrGANFpgT0LDnjcydwlNT96LE2THRI1ynje2ceHxom3S6XlUG1cSiAzpS1bEL xHDv+2AOjBA3kWAoL5EWH0AIFYAE0GDvuzIf4m3+vkq7MqI5PjPO1SDsNycimVtUPgbkWsfURhTE gNR+esTQjz0xUa2nUg5F2BMQ3UvHE99rHUB8J8MadSAq0UrMJqhBS5RyUwk9bT5kVtvJsW9bHc1A 6jnxHq0EAnBwZJPBAIywJZIg8si9HKCxGqkxQLGqQWilpYa6tAtGUC7UMkWyh8lkNX788sFTHdqA JdolVwUwAXOlFicQCS3QAsT8LRLSsEhDz3A7aB9Tp66ON+nFIX/mPe6ZKQdkVoaARCmzcccQeMj9 CeDmBITQG2qBBIaAAy0wCl4vPcixHNchJG4SMNYe09fyOkuKGm7rV03Stum1KlqLJjcBHqwwLkX+ tzwl1Bv44wcnkAKvwiPyoA3TYRr3AS9Q0jQ4pSZrYn38MorDg4MGvbT8QiQNTPiJ0WoMgPhAwDxq UQBQ/AEpwAre0fOr9xd7ItUAYcrUJ1OuWI1iZWoUwkiWRpmy5MpSp06mOn3q9JCRJEMVR31CWMvU LnH59p1EiTJfM0sgFuDxswDATJo1bc4swMCPlwItXEFrlzJlPnO7WLEy6Eqgq4cDP7oi+PHTVGIe QVoqaKpjJ0usbLmyZatWMHBCzbYLNqMAkE8fABS4GbdmgQmGpkyA0QkaPLMozX11VasWVIpKJY3K +LHTQVO1bI2qNYqwLYggMZoSG2xXMGt9U7b+O9YEAAxDJ97KRY1zAyM8G1pYOsbXszhbu8QKJsiK a8aDR5UyfciUFcjABAUHtn3sWFnP++A16wSjwIdIWFJfp1lBEqEPJz5pk9cc7a6CtRIStCh5FGCw R1kFM6WblSRW5l0Fq72L2LSgzcERM8W0DergCS7s4jIQgAngIKSCFkaxxiTP4IEGP7BEEssWpLz6 CLNddnHFtk8SEkjDWjYjphlwJJxNEkZaKCCFSNCQ6cDr4CrACUM+aOGTkprLR5tj6tvFsfrKC8mr kcRq5piwoLKNmGOa0Ua25sQhBAgGGNhBEiwStPHGAqZoqQI4pgmvOXnEaYaYC0FsDDPBiNnipRlr VswHHmumodIabczpr7l9rGkNgA3IBALHMG0sYAdDkJigBUagscbKvuDhs81giOE0mGlWFDTUlOAJ pgmZQMCDERAMBHPR6z7wo44NFsAiGPAEzSfXPM0B50dRf5Vnmk5SAGABHLbboFVXbVxgCkO0bKGT Y3z9tVpRV4IDBAYKqACLSNhgYFlxcUxBD0JmqKALS5pJ01p3zRLHj1WLPaEMPaQTN9+3CsjxEzY2 mMCJTqZ5t+B9xNlxgQI2mMELJE5QVF+JN9Cjkx0mqGAGU8wx+Fd4LJlh2xamiFU6ZRcNCAA7 ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2615149&blobname=jkns-44-405-g003.gif R0lGODlhZABmAPf/AAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///yH5BAAAAAAALAAAAABkAGYA AAj+AAsIHFgAgUEEDBJGgOIqmSs/XYjsmEhEyRMtfiwdC4anxUAEBAseRCAHW4EBKFOiTIGJnLtk coAoKSPnTZc7T3YAAXPo0BstStKkIke0FhCQJwcUTKo05MGEDCIQGYVJCw8PIlq0IPKmU5cdN2aI INLliiJomEQsFYhUJEmTKlGK6OQyWRoobw6BuZIGzyFFz8ZBgybLkqNDeOWAOUsPX60dIFWGJGgQ aoU7kIBgbbEDSpkuT56kIHJRC9AZN3gA8QOTwUe2SN/ATVlACzZ819Jc8eNHSxk8g/ykkYMHMDlZ b/wMwlPmCpQuPmXjo2dJw8CUB2EbjFDhxKEuKU7+qOZB5AqYNGCgHNLSpUyaz0/CzmgBpZQsDW2z FyipUgQmdfRAAsUgcmgBxnJvJHiHHH4AV0uDC8pRUxpvXHGFXoPEQw82QMTVFFtQMZDCIFdw9lwX SiihRRrvaUHEeRKmYZoSfHUhUynBWEeZQfyh9EQy7nQDhl9vLHjHHXhIiKQfSy6JBx4JPonHgu/5 UUYu+MRzB1MfFhDiCYrEt0NpXUBxRRlvvAfGE2C8gaYcZfhGUxpEAMFDKq5EoJ1BsqGURjf0dKKE HxISeKSSePDmJJKJQillozSVUcYdfmh4H22wJVQBHlDM0JlpZYAh6nuflQlGnL+56R6cUEjEAyb+ o+QHUp9gXOMOGEAM8t4Tb8iB5JGKJsobHmkEp1yiCz4J4ZR+vKHENfQ8kwJKICEUVQSigkXmqafK gV4XYLRXBhRaFLlgkWnKGFotaUxW0g3J0IOicBRqceSUwB2S6CG88QYGb4MErK+vwjbohyOW+AFv tB4oVVkEEfDwxg488GBme+dR6G2cSoChBRQdk1rTHQnGycMdVwSTAlKzYlOKO3LckNdwNi05SE/5 GstbF8oJfEhwwPXbIItvgDEDNPi4Um1UDGhwBw9PkPfEFb695y16e12h2GdpdCGnpFyjuIMSjihN kBzjdFPKCWk0iyScxv41iCKK3Cx0sXXf/Ff+3vwqSpy3WgCB9BUIWTsuETdUZKaBLF7NoqRFp7Fg uOCGG66k6aUHDRRtydHNODto3avBU1LqCN2HMckoo0/eTLciP9+83HBP3kHnHe48Y20EKShygxK/ Q3Eii8NJTjJ6Bf5mO3uiNn9eqEoMUkotDMTWTSonXNEFi3fY3aAih/3liM5MyjGwcuBDcrrsviKJ YBk8yEIP0xH4dsMOdZopqqTbtzdyF4qAQk04dqLmdc00QPDWM3hgvTQAAS9vkNLc0nc68IWPbvoK WAVRpz5IwE45DOoXi4hwCHxARQOHQBxpzKS9U33mCjppT68s8SRFWIIIKWjB1DCnJqBAIQ3+pegE UkpiESAYj1J+4KAjIAGrVFgCg8vxwyHUp4gyPCENNoSE+hwxvtgtxzldwEYEErIaHvzOIhYCV6hs 1IIZzGBKTMSEH4QnByWkgAfmIVWa0rMDnkHjBAJ5QzdCB4UjAUuKUzwEnYTXBUh0whI94c1fINGF +bTgCpiwRAchsbcPRgQIuUBIBPBQpt89YXGMQ88NWpDDJ5THa0SIZUWi9jw17gUKTwgVcgKJjcT1 ymbK0ZcS2sjKFvBAI5iIG+yAoJU2ggEShrGEJk+HM+fwABJR6Z0SoGDKqWmvCwmik1Zu0AXyVKQi 5AFCeRJkE/eskWr/SkYKCiDIGyRQWMv+CU6FZpCCfs5nBloYxTFKsRxIlEIRw8wharK4RPX9jDdy kMggIAYFPDzhDkQwE7nY4x70JPSSSqhTipQABHUCwT22295w4nRKRaQhF5B4S+IIRjLg3MEq4Umc GclJFWh0AhLBSEYtoMDKfzoCE4cBTvj4hRMeDIIBFfDDFUr6BIuU5arE08IMTtACK1rknLIkwsiK dipwaYFq5LpDN04gmzEN5w6QwwMYJgKGTvihE44wTSqu0YtS9KIXQk0FHixpzE4gdRACDM4H8eAc PDDgBoNAHEnRODWOvqeSJ0jBRWXpyrC+aY+h+kycPnaHXmgNG3gcznL4JQceaJYc0Oj+xTM6Malg DOYa2MjFKI6aih20caGPPIwikFW+5oChfm8QTUZP5DX2+MZN/eQMHs4Z0liWVEEs6oL/QnUFHszg DQcV5Azw8itKpeF3mIiHLDohC0VAohaygEQqBjOOZxTmGE+Y0gyc2ongOuKyYJDDIIp2haiSNHjs 0ehZDRSqG2QWCn54gjorUlJ1TmlCNtICnMD1hBk8YRDQuAM2ZnCFIinJD2C4gSWS8YxcPOMZyYBG PK6hiE4M5hi5KMUoXEEyS8ihC3gYxSgeyclBdC9gEHlCCxCaAuFZ6GOL89qpdMPVusFvwrFUTa8m JKPncQtxb7gGJkbMq5oUCcVKCEb+KY7Ri3EE6RgepJsrXMFFKoJvFLIYnyX6u2dNbpFJD1TCHYDQ ZBZu1DnPYd4NRLADww7apETgwdjSxM41yRBzWmBrMnLRDTvRhJ22K0U34HyNWrjiEHCN4F1dMQpL EIhfcXS1IjBhWExgIs6RrCqKV8lCqn1MC1U1jWl4AOT+ttZOJcUjgXzlHo/l0WPg6movgjHIH1I6 OXjA8SOPMdBUHOO/VsNDKhTDILo5UpNwda8lMDFcND0Jl44Q09RweQWSGvqswisFJvAACTlMZDxa CF04KSSpsRHBQGe9gRY68QxseMAzb5IcJnTL7WA0BBqlsEQqPNYXJm1vbgh7JCb+ygmEO6y7bsQK mAMdAbyxOZc9ZTGN8MwkvUPI4TBKqNgDFbaia0POPAa6QiyfgAncaiCXRJMcJBqUjGBYoha56EUt jmHRviRJwPzSMRNHQbdV7mDPdQOYH4AAwPjwwDRU0y4un2MmFhm7WHUkzRUGfMpwJihcbgqX0GWi BEhgoxspmEm6aOKKruRiI1RxcS4iImCLYv08UhxEBR3RTz+wW2/8asFicgIE05RFVNrlqB9K4UiC 8ssRJBOgiZF3LvekKfRTC2nRsRGaLkjoPMe4Xi9S8VPg5IIctcho44v1s3DlK4lPOIQbyzCIW3MR 1S1QTqQ9T7nPnEcR9hmyKzr+EbBOZNzV3buCYYgguZoMMJbkslDUDnENIT0nXaUgRzJ6oZFj1AIS g6jFNXD1hBAC52aiom49cQctEBZAZhhhN12OgAfAc0rNEypKpgW8hyQ3ERxzJ03jw28QZ0aTci6X EyofUyejAA3dwIBTVga10AtRN3Gd4GJs9gyKpAUSJDDl4gfQREVE4Cl3UGMZRCyHQFDx0ULiogUi oAS1wC6KoBxIZXv4lxGK0EhloARvQAQiMAPGY3fo4Ryk4QrP0A2DcAMnaGVlsF7Fkgq9QA6mh20C oxxvEDBUNAiQ1BcIgwmxUxxv4ERQADVSZj9VeIR4UgqpAAnnAVdecwe0tSD+N0BlXFV+btJDZaBw ZtgNyscejWgl5aIrxDEIrrAckxIwxQE7P9MFcqQvRXIIS3Q6nPQzctBvrmAJVzADO6E/aSAWNzBd 63YwupKFGfYG43MHWwUEOyACHkAEUzJa4WIaLdAFrlAL3eAHEgM2FEJpTJImd8Avv9Ezr2OKwXEI CChgp7M+46McSuAreFVJZHdWpxIeJ1CFybFEUKJd1mQgvTKFIrCOIsBoCxInvlZvMwAGz+AKJQgE GnAmodImrpcgDGI7lIJkf9FJoLhEe9OQiURKYCACQrF4sHhWYMNKJ5BZi4FUioAk46IiHBeNDtaR IlBmMhJ0kqYEqRAMo1D+gkoQFSfSKmNTYqQEcwCThK6DQXTTL/g3gCDHky2AAFqACamgCFoAhqJS JDjUApl1A1rTSEJ2QxIGLsSzIDvQkWA4cAckGmlADqPgB93gCGCQEAjAkR5QARFwAjlXMWeXKAy5 NxvkLXDTC4MwAxlVJGlQlFKxicdQTirSHsWiZDnUAnIAPnvWCcnlGfszZTVREYwDNi+UE6nQDRTS DYrwBhBTPSESARrgAanhRjzAfNj4M3sTHC6CP6nxBGzJlhGAEAVwGaPQBc+ABxTDYKJilvMBHfvG UmhlWRxXNNvka9qldzDUBeRwDDtQEqg2ix6AAGNUEFFRABqAGmPiJo3+1xNz8yQ/USfGtGhQpQEM MAAVoAEVUAEtAAnHcAI4olUdA200gQfJ1AkocybaVZAdJSPuURZPhjHORlKQgA+yUAGygS1xcgP4 AVVjFJvqyQMhtQNudAV+wRs5B4wZJWHAk57RWTgVsBq2dgz0hA13QDGOiZVo0p/5CXpgky57dDHH qV1lwQPR5w7Y0C6yUQDTKRDVUwEe4BrWYkx2skqXdFExdwP2dEqI4wHkqQGh2TQeUDGLwQMDoAQq CAZ3VDnnMXjO4zFrFCqkIp/cQjl5KDPqcAxyABIlgQAiYCYrUwEIoJ4+6gdKcAIH1393ADxh0QJL qXBftRcz8KNxClX+6ekaEcBMPDoK6pAL3ER2+fk47gR6lcNRmBNalyMqZ0WjSnA9OjKiJwARH8Ok PgoEJ3ADqGZ7qSALmEB6YXECVQUEN6AegyALriBYllAGO5AC9+gBawlZo0A4ArGe2NALFaEEMqqb lClapuJCY3qsV1BVM/Asx+ARAyFIihBgSikCFVAxlXQF2JAM9ZEKaXAb6nAFYfFAN8AS8YAWpXAN caQIFdMChcoD7wE7J6Gjb5AM15CD5BJzD/iY4QIFzQouXuMcrgQ8bzAOwUB2uzdPsrE9c+YIAssD bAMET3ANBOoK2IAN5EAP9ACv4hFpQNAL7oBbihAMFvcM8PoGsCr+AilAFyF2CALRFFBwDNjQKSFF I6axPwWpXQcXsAn2MbX3BCKQIQurBP8Qk92AALLxg8tYC5bQaodgn0/QC/jQC7KABw3hCr0ACa6V c9u0ZuowDkQhC92AD6OgBWaZmKPQC49EDodQLQZRAETQZmUQeGvCQpSDqU8wChXxrM4xVW3kWifg Cu7gCgzkCP/ARP/QAoLERDqWC6YWdeSgCFdQC/QwDq5wst8KDezCJqfkB+SADccwf66AI/SQCo7Q Ce5QX5u2W/9QC3PbFjeQCuqACegpHq50VlJWFu5gCYkTexVxnhqgBddwDaMwAwVRBsmQlPEQAZ4z CKNQCnMmC7L+IHX2RULyRxWmNhjBYIO7xW/QoLlAlQqpkILJUV/jMKzH0F/HERIoUQAp4AgtBgZY UW+SaSEpgmpDN1JOeifQwGPW4TCOMGNPQE/dIAedkAo7ZmqycHidsAN48FeuIJbSUwuYMBi9wIXX 4ArtJRuyEAxa1DHjkAvQcA3PYLOxJQuTca/YcpnBoAXXCRaJIxP1RlIUk0NQoBFYewg8AL9rgcBd QBXTC1+02rXfpQjJgCOHMDWQkCRQEHjilgsxUQY31AnE8qzQ8Axb3As4FlS10F9i3F9D1l9efMK1 UMbTK2RCRsbT03DXULp9NcZ0LMbJoF4oy23HkMLJwGbTk4L+wZDCpoay8EW9uRAMWOsKwXAMe7Vp tAoNxzAYyTDJXLzEpXDJmJzJmTy9mszJnHzJnwzKmjzKpXDHbHzKQqZja4zKqazKrHzKoMzGsazK pSC3bgEbrzG7IsEWO8I0LLMnc9sjHjLMxFzMGiATHsAlxDwSbjESI+GZUFEZUMUDYFA2+toN6kC6 XSCv0QwVYyTMxRzOHoIAJBaW+PAP3eAKWqDMcVEZzuzMIeKZ0pmSh8Bp7kAYUrtnzJgl4yALTxCb 8QzO4hzOCAAEltAN5PAMu9cLJPgP/xAMLVDMT1E4aCnNnikCO8Ge5HCmZpk/cpJ3lFIK45AlbwDN PIINAz3+zBFQhTK4V+PQvlx0BXfARYqgsfjgDm/AzgNQPRQdzYWDAB6QBhqbzfQXhXIHBeqUIpJp PvTCuu4wCpBxEHJwDSktECIABit2vKUGCYbERZ1wCDtQBh6UJkGmDklTAeP809ay1kENDe7QCxiV GhZTJ+RBLkSAYjJXJ/1HSiL2D+MgB+Q5ointAaKbzmnANrkwPssWKngAq3dgwtCQCwMGCePwD9Aw A3GBlj69HV3QfoqAQ4eK1OVCLi4UjRRy2hyTQB4TDNMxCtE51eLMtKNLvZYAGvQqV09sH6kQYRNR q0tXC8FQjc/wD+SwAyrhzk/BAIU7DmCtNS3AaD+kRiz+sqV2NyEDVAZEICk1iw/kcJawXcwekArj cDOloEhT8nTeR6sTNwr4RxxRmwrPsG7QUAaHgA1+TaUoUdHyvAPNaxHOQnYtlKyQY5c1xRxAMB9B YUTgYtajUAECHb90iw089hNWbL0LvF7nu16yoG/SlEV0Mwq2cwxWHA//cAwaQC0/nRBKgA2OoBPp SnaYyrP7KSG+QhxR6EbNRK8dAwSYmww88OAFAQbkAAk/QZ+YoW/2UQt4UgtBtOG0NkVMhMVt2D1p mwzobNw77c4MAAXYMAgUEzofeB5TRjxbJiHKIqE4juOecXYpg5l9Er/xq5xJsk3LKAv3t0SjYMRQ i2f+raZF0mRYg2AvljDT1YwP0HADKM7Tm9paLXBS0NhRB5kmSmIz5iofBTi4FZKHZcDcIhYX8psM PkEEMw0J15sLdl7eeX6EC7yMgEhrUQvi9rKqQCbkg0QtPA0ECYw4O0E8pk00COkrRSKXdOpGqEHs BVgsZLEDR+gIKH3ckDRHXdAJcybtriC5rgAJo5ALuVCr1lurqaDKgQhAqWyWDIEPZXASB5EC0DAI 3iU8ruct7PRLiGIkyhJZbiQfxE6vuoHUYDAOqdDsKUFC7fHt06Nb1kurnaAI3X66y8jASDW9mPAG kNBXDw8q9IAJ5ZkQIiDZ84F0NEHjNU7vj+Ir/XL+rUiK76jhes4IBi2Qws1+EhrwDOXhCEc4Pddb vaZuH6d7yefr27OWV2+wXrcWtYEOBArdMAjRCcewVRaBJlv2S+XlLWsiaaR5E5q0lMQ+H06fJic1 AyUB8AXQBbmAEXP2x3YOX7Xa8NPbCULGwFy3RHehCH0+h7IQhQeN2QiQAt1wBR5wUlYTIYeyIDY5 EVn/W6nxGxF17/kVI/suoQ2XFCcwDgdzB+fL3qUguecLiAwMymwvcng1CAE2cX52GJYQDG3TBfSg BDst1CJAzdE46VRSBgfeTClg7M30T2AITe9ROpIOBtukAf+O7rIADYdga+XNjamalAlva8ZPa63+ NmuQECd3IAuk2/nqw3BWQgTxAAYDEAG98ATZ02wfX+Mj1Ey/dftakeb7VQaPdCTxniYd0zsmUQBg 4A53IOJBMwoMvH1psHQ2qGMAgQkSpE6OMDm68+ZQqmvXjmHqBMlSqVLYHN24QU7OgB3HdqTokkZk mTdyTL7pwmNGi5U3ePC4wZJIpztdoBAhwgPKoVGK3rxJIychUJtA/GAboKEbtDe97nTqNMqVrFKd /MgReMjSKEyWIDmyVFCRHEu91LnDJstR1FKjOkEblIKHOj8D7lhKMYNIly5gfpZ8U4ZIC5YzdvAg AgXIDiBvUmHyI3KQH0WKIKcpI7KknJ9Antz+QTpDXS8/x7BWLYUJU6lDBEe1DetVoiNFljDlUocv HrRUtmu5SuUqWaobRLD5KeDqTQooWrRk/pkm8JUdLBk/eXIFTxctXfCUSuUIzCGxfvBAAvp38xsl V0AjqPBb0TWskCENsu2zNsROlrwqMigiV8gZB5txgqnFLVmoSiWZUiroghw8CjgGihuu6CKzkcAo owwgZnCJiCuuKOOOQzDDDI9OUlGkFkwAPOQukYIy6aQroMADmwgiUCKZWp5pKJlnMAGjIDy0kMMP SEZJhSuCoIKklGuwAZIcWYKpasFawMvFgzLIOWSAY4C4gojsygADMzC0uMIlHp7Qwq+/1AT+g8O1 XKklokNa60IO6Wo0CQwlciygAATwqAUMIIhIhZ5/elFkkDugyA4PqUZhchAwIJGll2SOkcWVY4JJ qxRZCHJlFEiIOIQcSAbApC/nwOCLwzK6eGKHHdqTDjCg0KSVuzRaFOguPK74q8aStPgMm0IZ8Ckm EEv5559I23uChzSkSiWVOxobJZdj1CEHGnfcUeeaVBdMVQkltPCjG0UG0AKPQ9pjc1burgCivQzn 7LDDOsG4gzY5KrNEEWGlu0NZZkEbYIAnfnqCsBa6wOcfaBx5QlhFXnPlECCAIK8WesiJx5VcaumF nF5SkSU8PDzwQMRrBikACEcgYdbMEdn+vALoDOsMDE00ay2jsjswU+SQ9KTr9SfOeCB0ACW6uIOI GVJI4Yl/8MEGDyLSuGOQQ1ZzJWtLO8mlF0z92yrmqahyZOwdjjok5zQOuUGJ7CjF7onmgo6TrzRo 5bBWPGg7HA9F/PBrxqj/5GEQZwfwwA8lWkjhhBP8+MfKIzPzQ6vgHOcqlVw66QoTTMELLtRQU5HD A0eSsaQAMHhY1e8ncPJd8J/r7OuNYPvCo+xDBiHLkjtshTq9zYAgtAAGBumC6xPmikfdQ0i6o/Ql S3nj41FkwbSTqriCPdWpMFFCAx4sCaaTQ694Ak3la4LCXSWgCFqtMgS0K8gBEpg4hCP+FMi4vmSm QzMqSReU8J5CNSUVkRlHtbCRrpAk6RCKWBFqMIWpA7IOD2FZmfpKIYcyiGAmyehEAfxUBvJ1IkGu WGEaunAFvwHwRu250XMcsSc8DGIytxpRAzEDlF6lhIIFwAM+yHENR30NEuPARy+AkrwEus4tqoFK ERVIGdo4Qg74KxEC4kUPnKVAIdd4xoKCkQtXvCxhZVBCvwBopuz0qTJ+UGAaroCZMmghMHW6FRM7 1AI5OKtQYMhgtaoVj9+Qgx6YkJrZzKaIrzjCD9jhiSXAokJM3KEFgyCCBmSBj2R0YQAM8MAgguGI kiiCjq4IRjDiqDAejAg7AOzCGyD+UZnHsalDgwTWT4LmB0l1QQQ5igACUiALIrwBEyxKAybUMY5R GAQTeHiDH8Q5GT9cYQYR0MAVljfCbnVrFH7IhQa6cA11KOIEA9gREAaRBsHdQSq1kAUmD+GKQvYv Me56w1qWhhnsiGRiGkqa8d4wimNFoHoDXcwMZqAEHihBik0pA2csAbnNQEEEO4gAA54wCEgEJzjg AQ8mynAod7jiBhFjAAJawCYzfUdcoApO74D3u/9laIe9rBUilTrDDJWBBxXAhLMqcA1F3CACEWvB hc51hZCJJEN+eAkYZnCCFuQUCiCUTSeHOAgPpAAa48BDBSKGAFj2KQ2DwEQtcsn+okOUQhFwUgJO Aje4K/AgBXsZGCIDFjDuEEEEM0iFs27gjl4MImIFIKsf6IEPLaTBW36RQ5/wwAMRaKACGshqwVzT lqjggSV4cIU7rhCxVzKgBbBly2PwCAafdNagQ8XOIN5g2BlgiC9GI+Th+tKFGTAADKNwlhLcMYpe FOCV23NFxtJgCWjIIU1+sMQhwXCDx7YgAkCQgwLDMptcDSsZ0OABbXNqFCYBB5M3OMEMoACFNGXH f4HlQRfAwgPC5K8vin2gwJ7ggc9VpABK+EcuGYC5FKThGdXaWS2c85zl0S9PWmgBETxwNTAoaZjl LAMeZHENcqRCBLSFjxy648n+5NVpwypKMRiS+BIlOIKfbWJMd4632IDxQJ5+cIVk3ZGLZ+xgACJ4 wjH+4ahjDMIV/OWLI6DRC3pcAwwRoFpptQCFNLCGRKOwhCziQQ96HOLFOL3BHZRw0huU+AotOEE1 8SOHTrhCNWDYLxiYp4Q0KCEFSlgTd5JKSFqJQAlvsEQunOWBXBQoGAMdB5vj8Q91vAEbz+mQH67R C3zQ4wka0EIwYDiOXnTiDf68Bm/OQo9REAEB8v3MYAicXw0wgAEiAEL4MHOHVAQDD8y82vMKKYIb OGdwcYoTsHZwg/I1yFkISIMU3fFWaHRD1dXCQzxkSpJg6KbNFTjBIJ4BjXj+uINltRBXPMJVC3J0 QgkTlm8XxmJkX/ebARXwjF9LlIpSTOQNASwDJHYX4hEB0Dl86c4TbhCUQSgCG448gSvo8YxcHBAb 7yTHPzpxYRjWIhnuSFkXNIBeYpMDIriERicgNYohPQEB1qVtBO7wTShUoN8pZcDKiZC0NDBzEJ24 FRBusAMRsakxiijDfn8WtFzBy3ileIYjC0CEY9AjHsm4QzCuUZF45GIU+LgZ2cbxDEWAgQFl6MQh HKQ6bHTZ2IrohjvcTtucY6WQO/q3BnaUZ5xgBoCDsJciAMicuzqCL6OoSWD8ViYg8GUQhoRGLZBS qHSOIh5fH8c4ktENctT+Ag/j8HGa1OUHIlRAFskIxjHyjo9j1MIdkEkFPjBxzwEUYAYamCsRFP8E X1cAnRpo666ibpOJvYF5UMDjc/BAkiuE6xkF2dkhgDagbliixd0olPVSAATvf80d5MDGNXJRGT9l yBWc2RpeOWVJWShiWw2ruxZuHYFeBMMdaRiAEDs4LfA5X4uACvCAFnAXfvKbwCKRzhqEjuEnh1ue j+mGXCiDG7kCSHiGJqGHXnCwm0OACAAJWXAUNhuNUYigoMmmKxiE/DKVUkiGqTCPFCsDS8CHXGiB iBmEVOgGSKCHt+uTAjItBtgREqymMriKLiACXRmU5TkEnLCJqPieNHD+BXVIBpkCtCugCCn6B4Jz lggIPzA7imqhvU7IJoXpLDnAAzlwsRbYGZQbqMpqIGwgBzCQqwGwhEbphH/QgFu5Ay04hLKiKyN0 CR5CFj/QlbE5CILToeawlzfAgwaBBp5wBUGCAjkgh7AgBwfBBvi4OV9rASiQsq/JhdByh2OwlUPA g2fAg83ZrpODBqq6lTIYBHeAhBTAuRl4mV6QBXrBkTJwhA8RARGoACgjkTTAg+TJo4SjCOAgic/4 nh2goWPohV7Ak6ijlDu4xmCABuhCAMFDgHCMgBtIha/ZJiDAhHhIBTIrA1foBop6AiAIhtHAhn+4 Bh0CAzlYGSLAN6xfGoQysK68WBrvMsYKCLHDeJMfqqY0M4u0SIgn4C0ggL5BkIUtU4dcYBZB+Z+y qIpPrAC6igAR8L1SGAdyUIdOmIErWZoPGod48Ks7KAW0wIaMwQeKkoOFcCa+48kBCAgAOw== ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2615149&blobname=jkns-44-405-g004.gif R0lGODlhZAB+APcAAG5ubqp6VJ18Z7CDXJ+DdayGabSMbLaLZrmSbqeJebSOca2QfLaSdLmUc7WT fLqXe7uafLqZd8CcfKRwnql9qLN5qrt9sa12sJ9uq8x8qdh8qcB+sul3qNBtmZuJh5iMlZyVm42N jaaNhauUi6yViLOWhLycg7Sci7ueiraahK2blKycm6eWlbKck7Oemb2ghb2ijLqkjq6hnbWhlL2k k7SjnLumm72qnLuomZmXq5qcuImMsq2DprKGqrWLrLqKraSbo6ecpryEtLyLtL2MuriHtaSes72T u7uUsrWPr5yivZ6hraykq6ukp7Slo7aqpLyspLSrrLutq7amp76xpb2xrLWwr6uls6yrvKenuLSs s7qusrKturuiuLyzs7WyvLy1u725vbm1tK+wusCdhMGihcGkjMOpjcGmk8OrlMKmmsOsm8iumsWx nciyncewl8KFtcOLtsOGucSMu8uNvMyMtdKOu9eKtcWSvcuSvsSavsqavcGWtNOTvtqVvNOGrOWJ uOSVvuyDr8Ouo8Sup8WzpMm0pMq4psS0q8m2q8a5rMq6rMa5psS1s8m2sca6tMq8s8G2usW8u8q+ usqzt8zAtsbAvczCvMnCt9DEvJeewaytwqSqxKyyybS0w727xLO2yry9yre4x7W80q+0y62bwsWU wcuVwcWaxMybxM2fyNGWwdKcxducw9KfyNmYwuOcxOeYwc2ixs2jyc6qzMemxdOhxtqixtOkytql ytWqzdqrztGrxsS+wsq+wca7y9ezzNat0Nuu0Nay0tyz09251t682NW61M6v0OKlyuOrzuqrzOai x+Ku0Omv0OK11Om00+O51uq71+S92em92eS0z77Czb3C1L3E2cXCxMvEw87JxcTDy8vFys3KzMfJ z9DGw9DKxtPFz9HMzNrHz9PQzsPG0sbJ08zM08bL2cvO2sbH1tTM0tnG1c7R1s7R2tLS1NLU29nU 2OXC3OrD3OXJ3uvJ3+PW3+vM4eXL4O3S5OnW5/LY6PDO4ejl5/Xs8iH5BAAAAAAALAAAAABkAH4A AAj+AClUqECBx5AeFYoMESKkwkEhcfbgEQInDh48ceokOaJnzo8ieFDpGSLyCJ4jqFAVKYkKj0I8 p/bEmXNyJEOFFkwROWVqTss9MuHM6VEzIh4kdfgArbMnaZwOGeLA+YOEhwUhQ6Ra2BCHTsY6eFLl OTUnT55VdVilCouKZ6pZs2TJxTVLl65aqmapUpXK1qm/p/qyyoWLFbBTulKlMoXKlilXqlw91sOK DqtTedSSxZgn1alVfoABy9WHlZ8+d/7wSb2HBxyKdCzAqUOHIUM6F0/Rwdw3z5zAnk2pItIXVSpc u2ahoqUq2CxhdHH9nZMql6lcincpNsWd+yk5rv7+Dt+9KrNa4cJO2dJlq88eYNWAyTrt506GPXc6 8KEgZOsGOUZNJMdrc8QRhxx/pSLLWKyYpQsufqmCyizD1GUXLsHgQospuCi2Voen5BIZYbiAGMxi f7mCC3Y76bZKgsKlUgtcddhhyy2UAMMKL6nJsocfGnTQQQ8bbNAQgD7mYVGBcuxGHmCmeCYHHtyF h4oqtCwXjC7EBLMXh6pUmYsrqewSjIq4qNJhd5FBJkwucoD3Ih1yKBaZLrTcRYQdq7By4412+GFL WoH+8QNtE+UBB0yZzUHEKqvMgcuLkNKxylvBmXIKKlHiMuEswaAiCy66ZJhmeKlc5gphuZzCCi7+ rujyHWTEcAirpq7Q8ZurmvJ1TC26DHFHH6/k4QcvgdrSnmm4ROLDDzTBYVZYeOQhxGer0KGrX6m4 cmlfc3CXSlt0YZnnM12ioouaaa7S6XGmrELmY64Eo+kqwhAjnXCqrIKgpnQdJ0stw6TShwZ7tOLH LXYEQskqtOzBiyw79iBTHXWAhIcedZRX3hxyfBveZYDxJJlws9A14YMY8qXKLrCqYksuhC22iy7p saJKqafsIh53/7r6l4ZqygKMdq7cAcsdt9xxR3urjGoLKxL7sIei1+axhy170NFHtnR4RumuPGm6 U5gQohIMLZ6lcmaUrKzqbjDEGDPLZV7iIoz+K8V0KXZ41kUW5iqROedcLcjIdfDTudSRjC1+rNIh L7bwwksSdWCN1tReN9mnZ4CVqFYqkfG7l3IQZpgXvK60nqIqwpReryrP7KX33y9ed0owwfzFu5ex kirXHYLQx7UfexAGTOXA8JBKHL4NcVa1q1yULaWXXjqLuGSGmRcqJW6Zqu27QNa6KrvrkkszpQoT zDTF0AJr6/KGl2Yw0J1Sr4qnCHPzjPPxw8JuoSxeHIdyqeAFJXxwBIjYIhVzwBij/DKW3egvMG4h HWP2srNSbedBblvXmNQUjFZh6BTNKZVddkEYVshLRBnyUpgegyHe6WIYutjFjQQoqFzsgVT+uADG xHhRCx7Yhg942IMQEFQeOCTIXatoC6Q+I5ksqWkWb8nQgy6oIujsJTynKBHgYpSLXUBxinTC1ey8 V0NaEKMvgVgYapLxoDry4mZ36QH0aLIHPShqDpayjMcs9a0qLQZWJVITu/RiivJxSEQ0a52XaIYh Uj1IRWQznypyEQwzeYl3qiBGrIjBwlT4IRl++MMtcmEXmtmFHMvzgVjsUK2Ohac8TARdgiSzmF51 DxnDCAYRjFOiFe3lQbHzmYhglS9NAaZ1rugSrHhHSVVUiBj5olkrdrELVrBiFn4QhCpL9CDC6MJy tUhCV+q0ljwgSDe/mYMLxZUqDvErTbD+0svpQNU6wgijnK4wEy7olS815WIV5QslNu/XsjSRsISc 5KZ2XtUKDdxBona54y3sIgsfWGoOVxsCHnDDtVb4K5CBUZYuOBUe7pQIVLaD3d7wdSZXxO4z+ivj CE2FnDG575OfFBwx6oY/TmJTGLS4xSsC0Qrk/NSSdqEFErTVGTz4ZKRwkMNvStOgPihoXKSzi+0c GjvbQeZUZ1pRJ6HzjF1sUoz9pANkmtOcvDXnGciIzCtekQz3YfNmt9AALMrEwl34zy7nTIIcxhIY U9RCJpmxBR544U1cdOaBpNvLlcIHnRhqUhh705uKahrKvQE1oNCcK/5kyDthGGOTuQD+7VCPGoyl bTND7nuTLf6JCz50RQjh+oEsPLMHVsBkFz+UBS2UlYepeW+sZ9pLhmy6F8I0R7Rz7dZZQes/91VJ tc0xRmx/l69mHBW0uXhFGf0Hs9/tAhgl8sFvzAKcS9EEO+ohQpROpBmesJFlp+UgdPSGP1L5b2fB eAbd8DfTTmIzwc8A7ZlKKNt8HRWbudim//QW2+5eSI/U6QNNqpWqVPkFJiDUX4cgUwTh6O1BdAWl cNAUjGbEbrXCeIbanhENCZdxGrtAV47rRgwhz7bI2BSy//zJ3fHiTBhCTMIqfNBciZjCN3soy6vw sB5UqUU6mb2QIj9ZL97pTabQacb+zXCbIVBBx7TjfQa6pjHkIw9VyaCFRofxx82f8m4YskhCYKIm iweWBTNf7pY3X9VCSRbTLqDkXb3cV0P81ZW7zwBVNLoUDGPoS3C8MwY9jMFd8yL5TcKwMTGK0YwO 5zjCsiXGMPRFFJhMZw6/0ZRcdNGnPg0mGFNr3c04NAubSthLoOWgTTFkWk9Hg87GmEYuON2lHOc4 GXK29mzN24xkGDZfsM5tMdrat6EOA4c8EFAR5KBfspCHbZ1JVdxsqkXnxIqaRVURMeiabGz6e99J zlcwokE3YkxDFXQmhnk37WkhYxubqi5vrItRjF1QnNPDwAUFUEKEds9BCLZYhR3+6FAYXqGJkyU6 jg23xOB8cZenHH6fhacRbmGAim7TuDMxoiHnhs8WvS6/c6qLzN1oHKMYoMUjBS5QBEexmwhCYKwL L0XyF7YOVokxXBfxR/OaW5jT+Nt0wne+YFc8YxrTeEWOn71pOc8WXZv+uctd3oxnUJx3xDiaLnrA 7nD1xxQt5lRhCmOLEwU7RCwElQoXPPehd2mom6ZbaKNtcFHnXBj0eIaIXDGN98F65+iCfI/fLuTY rrpvFSaGLpJAJZAtUQ6aqgWslGWLlC/mMrW3bsGH4VdjPMO8fr0xdx9MBGQ8nhjz8DTN1zfUafDc 7UPNl6d3jmQ5L3jbNlZzDu3+0oNpaUoIxFFMoWehQ7fBLHWFCaGsnWOMgn99tqp4tr+9SISdP5se 83iGMnh8ducXmebTZ3DRMICgZ2GhV2519m3CwAo+ECe+4Qr6BBh4IB2t0jut0y1hpAuxckMF92/R 0H6dBzuhFA0EZgwmSA9oh02xAAt1N3A89oEKli/OF3f2t2ngJmc4uAtDZSar5j6swHdNEhZzMATK 0hdFKAs0kwusEC/scklv1jf4k20mOA3NwHsENw264Gxol3zzgA/NUHe/pwwzyGM5h4P2B3lFBmE4 6HtFhnS7lS8zUws9oBvu9CJmkQq6wGWsIAss1TpxEybHURcWp3qdFn254Hv+PBZMz5B8/1Rk/YcP +ICCyZAMrvB8OLhploiJ8pdz0+B7AVgMPDduPVZGF5IEdPIitIRiteAhhLU+fugKg1EvuiALxYCF zReF+DMPoDcNzlB32FSGXYgPVBgLy2B20dAM+zeAaHd2xoCJZ/eMy1hkPSZnPEdUC3YMyNADugIp aiEXqUAMP7QirzIH6uNCxRQrEtZWEVZwmkeFNTYN9BANsbCC0SCM9BCJ+KB5r9AMuPB7zcBzlvhq L2iJZyeNA7hptVgMw6CQXLKQxOADPdEnI4UH3lRo/NhcORQYHbJiuHVD+tKPZxePxJB5dceJzgAL zEANxlAM+5AP1BCJNCf+DM/nDM4ADQP4DNLwbDj4jJc4gzc5Dcn3dlxyDMCADEhwIJkhE8VCe3g4 GIbVIdgxNRhSL7OQD+3wf/QgecGAf/ngezL5kviQD8PQktQgDfSAgtSQlgd5kwRJgDXJk+hChnQ2 D+3QN1yiLx4ih5+BXKxQFrZQaHvAMqViCz7TCmGUe/hTe+P2Ps5HZ/DIc9TwDLgwgPOQk0VAcy95 lvOQlmhHDTL5DNRwjNDwha+2jDHZedTIY31TIrJgF4OhC8BwDD5ANWbkTalyh1OTC8XQl8pCM50U ZDSjeqn3bNAAj3KWC7AQCy85D7hAZNGQmfMwjSjYDDUJDS8ZDdIQmcL+YJPCsIyr8AqduHPNaHfE QJQQQiHFUJRSpQtblgfs0Qre8hchJzkqkir1QgQPkiF9s5CMiXbKMA+PGYxAmQ/BQA1oh3aYRw9D dZbToAzJMA3QYJPSIIyRaZOguGrKQAy5UIaP135mpjOoAAzEgAx74AOYJRhuU3KyAEYkJx19Unuv 8mJ/hXb4Aw2vMICQSA8GConPMAxnx3OTKAzzcJYMCqHSoAz/GA3QoKOtkAuq6XzD12Ou5Wm9kwpy YAcrNWtrgwSmMTG20AqXAR5jQjOQIi94KBmTsgujEkqSd4zu84/xeJ33yHPz4CXNEAu/9wxFeqC/ Fw36EKf00AynUJz+NglkfZNzoYYMxlB3zeEXyHAM2NglSMBlQ7AHf3ELi5YtrCAHcQMrY3JJAYUu tRgNyIAMwriIXZgP05APkAgNsEAM+TBqd+oMKAiP9AALS2qg0ECrkEgNZ/k++dAl5dZ5vKN5oycv OgibRwAM5xYMyKAH2GIezAQr3sQThQGfQqBdK/IMOdQ3tVAEVGoM+ZAPu6CL+qAP+LAMzmCWzgAI ykmkZ0mr0xCZ8MgP9uqSEPZ80IAuIuSkwkA4yLA2/WIHrDAMtLAl8YMEp/AKkPIKM+MqKmIKYAor ntFTvjmZJZQKz3AMqJBXBnsMi9oM9JAPLcmq+DAPwhALIkuk+Yj+fzNIDfzwD//AD6EpZwS6lfaA f/agYO4aDHRgCl6CM94kP7LQg7XwA+60FlFyUI+RKmPiKsgxe/6jLuc3VMxGDLQwDMawD8aQq+jK qgbaavA4tqOZlrWaDP1gr5FIDcVQoP6TD+c6DdIwDfOID8yEtXtjGbhQDMdwsNqRBH1gCnZQARMQ Ey0FK65Cn19qGcKgDK35Xiyjoc9gDLrwDPmQBPmHD8aArvrwnNSQDLlADc6AbfSgnErqq0rKDzkq Dd1GDfbQDMtAD3/6e6L0CgpmU82QIcpAB61QDMaACjgkHz/gRAnCaDyhP8fhCjPDCrdQAXJQIhbW mhpaZLYwDQv+WQ/tUA/oCg3LQA39EIn0MLpnKbLNkKtOuow5mquQqA+jSbL0UAwb1SC4MA16oIP/ Cgsk9D26EBd8UAefQUFTU62KURg+swsTWATswU3sgSG7EA1rpouQyA8r2QqAsK9pSZOxYKty5qsG N7bUAA3JsKQRbK/JoAzQoA/zQBpfcxnDkHyu0Aqt8BYFM5hsgxHXYyne1Cf68ypxdQpH0A2/QAvt 4D/cmgpFMAvSGJ0Gd4/2Kg2xuwzJYKBym5aRiYK1ioLCkJa5IA3+gA/2iq6wAAsaAAgspAyv4AeX UQvMiUonRBd5Qjo+/AORUgtC0AdhkSqnoAf88xYPxArtsA/+/nAM03YzuEAEtBANulANfVMPOacP cLuru1qT8CrFxECv0wmPSyoN9uCSjgwNsZALzkAYq9AKfNIgqTBuQaYHZqYXnPIXRMAHZtEDGPAX kDJ4SniBGshK+3APxeBU+VIM/ICF84AKx6A+6BqJysAP0MAMzkDFtnqgbBeZyzkPlakP8CgMrGa7 CgpsrfAKpgB7nTYM7bAlfFErHdc2qcAHfQAge3BlY0GROVwihLki2MElh/lPulAMq1cLj4Gd+sAP 50oNxAgLy4CkvgqgEfZsBkqnnpYMgQCGO3pQMkkMJsMKzJEKkDoMkEpwK3UEukAc3KEHBsI1YmEL sJR+4gj+i7lwCxGWC7u1Iu1wNEdQCnqKLtKQvfUwpP0gDYGAkoAACzEZbV84agZnXiY4C9BQDc5H D/aAD9FAOgkWDN40B3yzE4ijkAsZVbO4EzBRBEjBNZCSC/MgD/VQe+HROrkHlYUVDfxQD8VAAfl8 M32DDCxpD/OwDMvADA4aCIZVkD2nqtbpqyY4kuiaf/MQTOSXarhA1bpgK5DR2PJDIrKXCkNgEqaA B92nFg90CpZDC1SDB+zpnjqlwDr4XrJwBO2QQ9y0aflcD/a6DE4cCIHgDMyahnKWDDbWV7+HeY3Z kMTQl93yGOIi1RSLYA/CHZsVBP/gD/4wBHSABFxzFsf+wTXtoYS5cNpIyHzHoC+s0ArKUEYKSSrR dwuQ6A/8sAzcuwwqWzcfLGe7kAy3EFpyhoI2SCbGIStVsoTHkSLSET4DpQpzMAunIATMDQD/0A1z ALjJkzwzoyx7sArKIgx6QAQNzgv1QAtltAu3wE1qdqDTUA+7YAzzUA+ezAyBAAiCsAyB0I/QEJ2r sEqqAB79CHnFIDPDYAsB7kKsQLCjLB1H8BilwindASGnQAH/AAQAIA/sIAuw3Fy0h1wLSEC3sAdq 2moPBAx4MG0eDg3vTZi+O+LGIA3ECAiBwAzMoOIt3QytIJm2cKVq9yY+1ZzP4Bl3gwuGGTZqYgth 0qn+2wMhEKQTeNANn/APvdAFePADdpA8zZUqt3BHLn0jrIBet4ALq8RNGspNzwAM9TBbxTAPx4AP 0HDiHCAIBG3mLLQK05YK33nGr6BioPWNKacZRNC23CR7BeYXXmIKAj7d3HEEXdANSdBxh8K7lOIn 3JQK0VBoOENKunk0uKAMeETN+uzAnZ7TzWDigjDqy4Crz9BXIQwIy5BedvAK2qI3A1UmEsITWGQK wRoMrflAjSFDcmAc3aIYPEEEdYIHRKAH7CAO5CAO7EAO7NDvA0/w3VDwCD/wSl7w8gAPA+/w8hDx AU8OFO/vAF/w7aDkC38M/z7w7WAM6qDkDt8N4rD+8A+f8AgvDr+Q8OLQ8uKADv3eDdpgCd7gDeHg DdzgDeOwDdtQ897QDd2g8+gAD9qA890ACZMQDuNQ8+EQDtuQCUvP8z3vDZegDTwPCZcAD+Pg9D6/ DZcADp+g896ADubQDpdQCZfADjIfDlY/9uxQ82+f89rADWxf9eFwCUCvDdoQDtwg89sgDiygAo1A CFDQCBiwBIUgBVUw+IUwCEHwCI6ADuiQDYPfCCagAlqwBpHwCI+ABiaACNrQCI6ACGSgBoiwBmgw CEbAAA/wDePACIiACJOQCJOgAjOwAI/gC5MgBUZACTUgAgwwBWyABoiQBmpA++Iw+48gCZvgCGD+ AAq+UAieTwNlMAimTwiDYAKEkARrYAMqMAhdEAQ24AthMAMzEPtQcAOEMAMo8PmTIAmDoA2D0AiP cAVc8P6T4AhW7wiTgAj8bwYAYaKQJDWDuKjxxS5RG0JRwIBxRAjKJG0VJ0XS5mtQiQQoIKiR0EAC JXDnCHHx9WnSlV/aCDVCQcMEmieOBqERIYAFFBsCEgzy9KiRohmOGkVqhIhJpBoeUAQZ5GjSo0IN zNRYc6OQo2zaHCVKJGVQo0w3GmkbJEmbuHCPejXK0msSpkSPEk0CR86bNjCefK1RwGbQIAMFFCSC JE5SJDCbGhFC5MuXozVqaKhp1KigGhctoAz+StCx0TdJNxaDyRIFRpAvVRA5CjLlEaJBVdQ0EEHD wSAdXBIZWpOokBpFvrJ94qYN0iRIkB5FWUFp26RJl3wRmtTNG7pJYrQQSvRgeSEyD9AkigpJkU1C gxSYGKRtUiGwUcETIsQE/4hBXwh96sYRScDwAooYUmhBEkkI8UWSQjRLpBFHzGhgkBcum+QLSe6a hI27CsGCk2yu8CKKu0xAARJflHNEvrsg+eqSNRyBxAEUEtFiBTVuUAOSXj4ByxHLDEhAjQgdscmE FtTAj5LHInEiEh1+0YILT7RphAlE0ijBgxsssUSbbsbUBhGwzhhkDRnWGGSSXr6g4pFHIFn+gxE0 BulGGzGuCMKRLxAxBMZJELvExUnQ8UYSqSBBI4gSBrlEho6wO6ebR4RMxAYWBjEkCAkdQcODEtZA g4tSBtliBUIi6UWUX77QYgsmIJICihu+6MWirxr5Yg0aGIBii0LYgOScTXIVp41LJrlBhUSyyQaL B42IZBFttqiijUIUoQ7GSy4Bo5dw5INkEBOYHRWRKz75RRJIhkOEBjQIcaIRSig5ZAr4SBCBEBeC yEGPLLvhRpIppLDBhSe4ucITTj7JbBIYWjjBEQQMgICBqKBQQxJLzg1nRkZQAOI8R66cJIonlgui kDQCVWQLKQzRZpFEFBHHFymkgCSRYA/+uYuTXx6hyxGqZFADihGcYKEENQzxUAoRHJnCiScicfiX bCRBeIUYHKABjA29oAqS0m5A5IYIHlhbikjQUKGRAQ5gAAFC1lgDgkUMUXAqFwhBksZDDDGDDCgI GdcRRRYpRDk5DUmk5ELWuASSRexqzxBEYihoipLNXAO8QQiZwoUmzppEEjMLgQKRyWlAwa4gwLJk DSMevLyNBg4YhAUVHGhkkQECOCCSLLRZwxBDHvEFjCeCc4SRRSaB/IADGmDDEnEqhzGcu6gyZBAI DEEDBvXQG8RMRFB4gAYRmPhUJULUUGOKEVxA3xEoFGyQiyuMfoQkoCCFRASnEXexhHP+oKCANdhA NW1QAyLW0AZMaKEbllCEG+6CiRs44GY2S4QbIFECAhjgAY+gyLJoFCEscAMSZSBDAckwlTWUoASI mEQJbGCCmbiBXlcwgi8ikRYdbKEE8/tbhHphiUd4YhOJsISDvlIIGEChEJMYxzYe0Y1PcOwRm/CC IgxRHW0wgiLdAOIlFnGA0ECgEJcAx+AmUYlEmAABEXDEt1CoiEvcpRt9XNwj7pSIKbRgAVLohQpY kAg1oGEzUnDCF1yCCCeRwAxqAMLoGrEYbUihQInAwacYIRE5WUI4XshTJQZkBUXYZRJcKMQjtgaO 5kyCDAj4gAMaAEduZUIR25AEDdr+sIhFQGIMn8gEdSZhCXb0cRzxeMQZ0sAXE6hhCygwAyJoE8FC jOUXkyGEk0YwyHDisBdiqIGlvAEFHXzCGzBYAAsa8QhGqO0KknDHJbyhz2ygw5+hQNu2iDaIRIRD HAc0xCXCMSj5RIITiIiCFQuhBV/cRRuW2IY70KEo7qChDNmZzyNSYAIXOKKbk2mEFBDRCCMQ4hFf GIEaBPA3LcCvEU+4Ajos4Y1tIAJabWCADShCFQaIAArigIQ3MIGOd7zjGtcAhdjCIAk3KOIMh9jG ODABiQROwhveCAckYPCFNDgBAiZIxBe+kIlwXKIbWMhTJ7nAnOB4oxuJcETaViD+BRosQA2O0MIH OicDwH0ABQp41Be8gAhuWEI7hriBIqAILUlwwxOi0MY2hvMAxHCVqeoYhTnMwQ1RfIF6BzAAzeDR zEhs4xLbaIsh2gCOS6QADS2AhBSM0A1QWCITyWECX7yQCTWkYQ2O1QZYJMQqDxQADTZZgxecMAIz RIIFdjSBadYAg+1ow0EMuBkMovCJLxRMElrgRiEsUYk3biMbjuiGO66RjnQ8TBuXUMQBAiUOc0ji EleYxDa2kYhqDct8jADDI3zIF0isZRxaQAxYFGGCGVXuK7MxwhekUAAEOOIXYeDEFUQwKhao4T0w 2C4M+qmNKzThAY34BGq+wAX+LvQiGzn4wiaswYhDaEOjhgADJ9LxjnRcIxT6pEIKFvEtS1yiRZnQ hjeMZwkJHMC58HBt+CCRicpV4hJzWohX12CGRazHaFkC0CMMgACD6KAXvwgCGeCsGTKogQ0mmMEa JEE2K6BBEqIQxTcSgQgxfOESVPCpN97wgkE0dRuW+EQ44uHUa6x3G1SAwSIqEY5NxwMelUimx2Aw gAEwIHGGOIMhwLGNSoSpEOU6QBp6xoIaKGI9GioEE6RQiAIcAEnxosF1thAFtKjBDCgwgAds0A1r aKMQZsJEJEChCOJcohA4yAIoICGTQrjjHTVzBCYyig1siMIsyW1Dc5xNkbD+fusSlUDA9aYHiTSw wQ3K+VY2LFEIFzQgDdOzFSMctAVPHHANzDqXJBpBgwA8YBL+8sUkmBSEjJmBBo2YiiKarI1PxNgQ jlgEDKhgjTDIYCDucEcvMOGGdJ/jGti4hiRwUAlMjOkd4PBCFV5L822kIZY3CFQkHlGJR7RBEcJU BBO6gYgZwGBbikALInCAhklwgxvZKGgjWCCgiJhAC1OIxAe0cCk0tO4BDDCBGSRRibxaYhFPiAIW 3OX2NJygClCogrXggY5LuCENbZDEKLDR1G5kQ+M5SEc5rAEKd2TCDQqtRARooIhxjKsQJPCCKWGw tHRiok45/4QnwqCDBdD+IDvoOEfoJREFBT0iEpLAAhegoAKtEIKKBGXDhV4dpnEcohCGr4RWKlGJ GagAE5c4hAg/oYRLKM8R5sDGkM+RDdc1rq3uwEQmDJGG17ZhYpeIR/gJgQLauoERhVgEExlxl0uE 3hJYYIACHPENdpzjF6BoxERuZDZ/csMJ7SEgSVAERKAKGqAcfrqZR0gDFliBBUiD4HOCisCERWCC PVuDTAA1fWoqdXgEGCiDMogACOC+cQCHcBiHd2C1NYgBbdg7dRCHM/ilQmCLdyEX9WCiQRkEBngB bTiHHuSGSciMFnAEyeiFbvgFFxiEJDiBFDCpDVGEQWic+7IBKlgcRQD+g2xAATRIg0GIKW3AhHjI BjHohGzwBkgYB0PYBvpKB3hYhDRwgzMgs0yIh8qzBk6IB546PncYBVGAB0xAQ0jABHYYBxSSj/lI BCaIgirQkXMZE1AQhTCYnUL5AiPwhF4ohBpgAzQggxRpBPooBG0ZBKrwANxahBlggb1oq3V6gVhK BNoChSPLhEU4g0pAB/pCh3HAwEVwg0rQtEPIBFK4xUo4BC/7rW7IBG8Yo2ZJKjnZqqkYhEOABBwo AIIyH3G4QknAFjmBPUewARuQgkkYQspYrEcwASeAgkDBBJcphEpQhBTgOC8ogzXQgULYxWJShG54 h0zgsuFLqqY6h3H+EMb7goRKMIRiYqZxKAdwsJYswCjakgJFGIE1gIT1U4QX4CNGUIOpMK4BxATv wgQ5QYQUCB2pyL8pmIQpMIJEgIESqIJHUIQnCIUEGohQqAisowFMcIc18oJFYIOCzAREgAee0j6W Y4RK4DhESQRtiEWCxMBKiEdJ8IbtOQTk6AZZEwMqcA45ATMkMQPzsYTMMIQUgAEZYAKTArwpMIxQ bBcXCJ/ogZ1BcIJx4AZS8IZDOANtyAaj7C1JwLJDKIMzaIMycIPBxIS20gZ4I542iIB/6wYBW69K gAQnUA/INIEEcAROq4RuAEjt8wbIjCJMYCKpawNLeIE0SIRtkI/+QmCdJ1DNyQEBETgAFCiEHNiC E7CzRIiAEnCCICCBESDDP0oD6UEETJAETCBD5DOEN6g3N3wD5dmySpCAAECAN4iAMjBNJbAGRQiH lgSC4hy+QlAACAiwc3gHXKyEAGMENgiDMFClY4ECGHgEbUCDNYiMxsyGScgCTqgBBzCAAFCAB9hC NEAEGXAEQyCEByCDQviADxgBKNCGR/AGnwu3KuCGStiG47OUS9gqNzAEXiQmQ6ACN/jAv9TFMoiv Q2iWSTgBSAgHhbScx4sHq9sGSHCDNxBRMrAWN9mEKMABscSoKHCCKGAmjZqEMPgF8ByAMrCBFaAB A3CADxgMgrr+CVpbx0SwyEVog6TkAhAARChgAkDEQHeYw+NjBCh0gmJitWEMCUM4BEwwLmIaB3gY B8tZhFiEh73LJzU6hKdhhCyAsYtihMWMTx3wgkTAL3RQB3awBCDklC/QhKBwgABYEvBAg0JAgxFI AUM1BBEQwnFYhGwIBS8YyCvQASqIgjB4rUwohyw6hH+rPGGsgjBoA+uxnEMgJjdYhHCYDkV4A1tN NUVIh074qs4sJo5rlU3ABDbYrkd4xEIQCDCRhE9QEEQwAQKUghhYjhKYAjb4qwBShDZAAzMYBEg4 A6cbSG84B3TAhG/YhntygmzwVEX4gm/IhkdrAwuthMwLg2j+kgFe1IZOKAcviwd5cIdvoKJCQICC XANUXYRxyCJFqAR4KAQqIC81kIFsCCAdsIIEWIBEUCUNmQ0aUAAWkJUbiIolaQEUMBOVnBPJUoQ0 MAMzeAR3AIVv0AZN+Ia769BWcw53KMMwEDdeDIMr3IY6FLBv2UfwO8FDgIEYEKFDUARIsIZvEbAJ /NZCMIMEk4EwkIsqgIQn+IAAUAQxKIQboJFtSAHzwLhOfB4UIAMYQIzZmARGUIEZUIRt2YZ4SFdv wIJsSLVAyQZSSMc3egQv+IR3SwNFkAQdqNdLyCJ99LLDbIM2YIRd5EUn4FD2YpxWshlEaIMaqNte +A0vtAb+jFWEGyi8bHgrTEgUqZCEqdiZQakMOQFdRoCEG4CARxADjcOEFvFCKsCBNHiDRcCETlAE TAgDVqtRKpABRmDd7HMtThtGLsu+MygETKABWYSB7PVQ31MEAtKW4aiB/7vQOYIWKqoIvMwGTwgQ HErNx9gCLgADcIwELogBGIDbnauCCPBYYpLIR7gCKkCDotSGCFgDT3AHgKyENSCBN7BQoPXDSnBg TVOocghYLnODA5CAXbwEp80EekIEO2mACGgD7nNJaHSdR5gBBuhI1dWGXuACB8EBRpKCHHiCKdCE XpCKXsgCR4ABMnCE8PMGRQCCL9iGRTABGKiOd9s+YUT+gDXoBHT4tEzwPgngOX3MvjdYgXGFhG2A h3i4BEYQ3jJ4g21QFjGGB1LgBq1CgwYoA99LtwdVhAEgASWoAhpgBEuwhk8ghdJAgylQAwOwCv3R gl/4Bs1EB/kAjm5DObci1hpAAS24hPW6VVmMAlrczEywhF30BnjQR4d9Axg4g0IR03I4Yk2TYCwd vgYQB3ewBngoIxFQg+0Ag1biAq8ohHPYBiSRhF8QBU14Ahpgg290AASopm5shE3whF8wB0SBhDBg Am54h4fJHfUo10BVr3PgBg0lG4XStG1Ijktwh4AdRuhszjAOB3jwtm/IBL6LAkXIBIU8hHCwK3bY i0f+MARF4OEmkIRKPEyi8YJlyoY3eYQbuAHvKgEHuJNG8KsuiIRQWAd/MocLIsCgMDpLmNNMKKsF oKAvuAZ3UoTOfLfhq4QzgOCB9MszGEzgMEN4OIcoxoQ2UAEqAAcM/Kp2fIJiaoIUeKNCiIJJCAd/ 2qpHaIJIsISPlIQAQoT7MpdfgYIE4B0w8IVzMAd1OAebbQMwOFwquIEwyKdPKwQdAKMbcAJJ+IaG XARoXC8IYIGd7NBMOIRhhITB+T1rOEE5jcWRzgRGaAMqKIEn4DJtCANLOL9w44ZrOAd2+LZFJc59 VQtEGJNegAIaQARCcAD4mIrDpupvwK9t+KpYCoX+bICEb2mCUFCCMHgDsZTIL2S1sW0DBHgBNPAG VB4+llOEMOhbJUjDb/DDQ4CjS/hJYjGDqsIEC9UGQ7BdweaGb/CGG5BZS4iMrtikMNka2lgpEqAB 7Hg9bmCqP4KvpXKtR6BgTHgCRGgyTJiBF4iBiEUHT8AEumiDGYAANngEndNHffzWRJAEMXiESwiF bnjDM3iD5sgE9oQENjWE5daizZWTJtAGHGgACECDXpCTRnDuNfAFUXiELLiCRhiMFdCGX+DhzMsT y4ECSziEr4KEyQVEKjS6GyglRiCabWDNQhhGJrCCThCDhIrrvRkDyCwmGR8FdNiGMpCAMshVaNT+ hkNAg0C5Qm94ghpockioghpAhyoQ5RuQgsJlIhPQll5QkF7ohTWAAs/IAtujCHfxmSaogkLYhhy4 gTRwhENoBDEQljAYAxiAAL6mgsFWBOlxt0vohdH2hlGoy0PohuFTaZXWUII8g1Qbh6KkU01r505Y rEI4gUKYKudAP7ysAhlXBKeL1n194R2xgcFoJENoyVbK7jFIN6qCgDIsBEawNUQAg0+83ir4AoZ8 BCtIA1kj027ABDWGa2h8Q12UpkOgAkZQHjnHQBgwg9fiqnggBTAosxywi7u1IkeoAgXxAgFKgxUQ A0UxikkYBBGoATIgAzb4PyQ5P61gPe9ahOP+EjBal3F+DgMqqIImAIIsOAcr2IECjgHQTIQnyIIo 9lsaIGldHEwSWAFE9FrI1IZfP4M2FAEvcAdtWBwYEL1Xc6BHwAJRQIdP4O9HAIMpiCXw2BAXWIEU UPcEUAAUGIQt1O9KaASMmnFvYNdi8gZdfwSuxoEq+AZ61agZePT69gIviLJPiKYHnEAbfQMPeIE6 8dh3ezdyFcwIKIA2mFFnHa+7vYEYsAFsEy1FebYBzQxPEINIIIT7QQM2IAMTiIBGutuCCent8AZr oFfX8mxJ4IKJbIMv+YaCRZQaeAEJiFotyAIo2oQwSM7hrQRmZ9qCVKNiugRQuJJLEMwziID+CBgH NfpEqmCDNoiBBmgDThh6jGWCAiCBBKABLxAaNEoAMiAEHYACCYAByUoERsgBYktXdzgHQMMv5UgE K4ACkxLeNkAHmu0twnbgSuj2Wb8EOb2ExAXuVssBcBg+hdy0cwgDzBptWYwBxjmD0VYEAX2BG9hB UvDBUOgFGICPQaABJ2AHdBADJwgfG9h9NJAC4HU2MgQIb+jOnfP0yZIlSIUMKWroplCbNooqfeNk zZuXQpPEAEF0JoKbS9sgXXqzqNKlRYkSLTrJqFKibY6YZLsU5tKlKFIWoZHELVsiSTZgrNB2Dd26 UJseTeLGSZKKD4O6/XJByNCULIVOqIj+QgVduG/btnH7hm5RQoVncFjShgnTo0eYIEHSJmnbJRyF oDSh0mbRGTeVBh9axGgRlCs42CwyBGmbpUIvEDnRtu2LokJVRlSBhGNTp0uPcLy4wS3UOXPcPhWS wq0slQcoInmSMokNISZoaNBA9EgbOm3dKm1D5w6TpTYwls+ooijbmMySICliJAlTpRSMalRJZGhR GuKZRWaqNGNHGEWLDjF69MXGDCiG1lxXQ8NACyaPPkhC981GAWpAkogX33TzDTeJuCAKOt5oU8gK UjgiBSWJQEJIL54Y0oZolnTTTXHueINIDA+wcUMaa6TxyDbfZEMFTNgtgkkmhTACRRj+LTWWCTxt uLGNO9vAk5BIizgC0SLU4YQJJ5/AYMAAJjCiCGdRRAKXXYVI0g03W3bjyCecfCOGFl9I0tokkzji CzcfitONNhS5404o3lxiCBpxZcRIG4VY8kgYUECSWDfWzGgJI4V8A08mkGSziTfbhBNOi/B4440i l0DiRhkmrDHCI4p8YQ4imNCAwAErJrLGGo5I0ohPUpzAyAyQcDGJNghB4QU8/sTzRCNbXOjIL6Ag 0o2DIHoz5zi5KvKIJKE+sogiNzTihaaHrMGEO9a8dRgjyEb6zTcOZpKJSNso0o0liZgRAQoNmACD FNskEsk2MSyXgiGPwADJIFpkA63+N2LUkAgba4DBlC/a4HAPCGKIoc0jLahBRiKNeIJIIWbcAMmH c2qjiAkMNJACBA+8kEYahSiCHBVSRARPNt6Uo4023pACSrdHnZONJODkVaqoVrTxwgEISHCGGd30 ggUjh0gQwyCKvEoSGD8N0pYiicBQhhSe+PLIN0v8E0ITYpTjSAtkYOxII40kgsYaQeHlziNrFLJI GSeYXAgkloCBiCKQ3OCEIWlQO+c5y56TjjnXXIPNNaRwo40YomizBQiTiAOYBGawkQYZjzSyyULT QiHFpb1oc44kiqCBhtdqoGFDFWA4MoklrzVhBTpSDOJECy040gUQUOQgBQtbfALW50CSgFcIDhD8 lU02CyuyhhWKOHLIX+Uw7h83vZSFzjuPv7M+Oh9mUwkm4SSiSBpupDFlTTh085ag3mxyxZ9Q4B3v 0aA6bEiEE4LgCG1U4S5NcEIjWDCCEQTBCVMYwQqiIIIaXAEMYPjEFaLgBRzUwAkpqIEUqvAEFqyg BidIwQxqYAMrUMEKYviCKD7hBSpIrBe9yIYoOOEJa1hjE6CwhieuIAZrIGIGvZAEEGowgxMsYAA1 +MITeoGjL3hBCquDwhNiOAMn2KCLNUDhFFSAOxl4wAMBAQA7 ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/go.gif R0lGODlhJwAUAOYAAKPE1v////b4+ff5+szd5naQnqS2v7PJ2Pj6+5Oyw8ra5XOMnPb3+NPj7OXq 7ZytuO3z9+/y9H2bsd3p8N/p7rbDy9zi5pqrtoGcq4eisb3U4Y+sva3E0aW0v5ayx5e1xpOzxZaw voimt5u5yuPn64+tw+3x86TF1+fs73+YrNDc5env9Ku9x6a4waa/zePr8bDG03eSpOTt8rLF0tji 6N/m6Z2ywXWQobHM24qpvYKftLfQ3qzCzoWkvN3k6LrHzoShtIqeq63I15utusXX4aC2xeLq8HuX qNvh5YWkt/L1967G1LnFzerw9NDa39Hd5rDAyb7J0XSOob/T3e7099Hh6q3L3L7L0Yyswoenv5W2 y5q7zpCxxqfI2p/A067P4HqasqvM3X+gt4Oku3yctbDR4jd3fkSRpAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAAAnABQAAAf/gGeCg4SFhoeIhGaLjI2Oj5CRZoJmZZaXmJmam5uTZ5WcoaKdlF+m p6ipqqurnmZhsLGys7S1ta5dubq5JyFOAwFKDbojLBEBCBNWu8xdrgDQ0dAZNQhTPFcBVQAfLQEU MFADVNLlAK5e6epeCQYBO+kbRDheGCgQ6e0BGuv9rlsAA24R8SPAFhAuOCwRsqVAAAIBHUIUKNCV losYtQBhEkDLEQsBAsjQsiCAAowlT2bM6IqLy5dccgQJcMBlDB8vuNxw0MRlkgc0YQp1haWo0aJS kAyYYaOCACNYdFwIQKNIBwErjmrF4iqL169ee6SIwiCACRUevEoYQiKAgCclOMDKzeJqjN27ePPq 3bvXlZi/gAMLHkyYsCsyiBMrXsy4cWNXYCJLnky5smXLriRp3vwokefPngMBADs= ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/wm-jkneurosoc.gif R0lGODlhFAAsAYAAAAAzmZnM/yH5BAAAAAAALAAAAAAUACwBAAL/jI+py+0Po5y02ouz3rz7D4bi SJbmiabqyrbuC8fyTNf2jef6zvf+DwwKh8Si8YhMKpfMpvMJjSIAgErVcrViqFyutNQNS7JaLRmS PTfOakW73RFH2PME3I6fd3VhKnZrIodmcHU3RYg4GFA4tujHx1i3mPgQaXgYWSl403e54MkA6qa3 9xXYKXpI8TiRSug6aYWKs+lgKZlpmyha5QVZWnkBS7nal9P5J3zqq3gAStdMbAtM+9oY+7yLK72W y1kbqpwsCz6DXDYOUkgdDr0W6xwM/3xuSvLI/E55mRavuy9vHhp8w06U+5QnIDeEqgbm+/ZQnz+F 8AIWtIcx45ACADs= ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcstatic.css BODY.pmc-body { MARGIN: 1px } BODY.pmc-body-table { MARGIN: auto auto auto 1px } BODY.pmc-body-figure { MARGIN: auto auto auto 1px } .span-content { =09 } .front-matter-section { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .section-content { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .section-title { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .toc-section-title { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .back-matter-section { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .footer-section { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .back-matter-section { FONT-SIZE: 80% } .section-content { LINE-HEIGHT: 1.31em; MARGIN-TOP: 0px } .section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .toc-section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .banner-color1 { BACKGROUND-COLOR: #3c78bc } .banner-color2 { BACKGROUND-COLOR: #a0c0e0 } .banner-text { TEXT-ALIGN: right; FONT-STYLE: italic; PADDING-RIGHT: 0.3em; COLOR: = #ffffff; FONT-SIZE: 135%; FONT-WEIGHT: bold } .banner-text-sans { TEXT-ALIGN: right; FONT-FAMILY: sans-serif; COLOR: #ffffff; FONT-SIZE: = 120%; FONT-WEIGHT: bold } .banner-generic-logo-background { BACKGROUND-IMAGE: url(../pmcgifs/logo-generic.png); BACKGROUND-COLOR: = silver; WIDTH: 500px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 75px } .banner-journal-publisher-over-image { MARGIN-LEFT: 84px; MARGIN-RIGHT: 20px } .banner-journal-name { TEXT-ALIGN: left; FONT-FAMILY: sans-serif; HEIGHT: 50px; COLOR: white; = FONT-SIZE: 20px; FONT-WEIGHT: bold; PADDING-TOP: 3px } .banner-logo-with-journal-title-over { HEIGHT: 75px } .banner-logo-with-journal-title-over-placeholder { Z-INDEX: 1000; POSITION: relative; WIDTH: 390px; FONT-SIZE: 20px; TOP: = -75px; LEFT: 105px } .banner-logo-with-journal-title-over-placeholder-content { TEXT-ALIGN: center; FONT-FAMILY: Calibri, "Trebushet MS", Arial, = sans-serif; HEIGHT: 50px; FONT-WEIGHT: bold; PADDING-TOP: 3px } .over-logo-journal-title-sageopen { COLOR: #0055a5 } .over-logo-journal-title-sfesd { COLOR: #ffffff } .banner-publisher-name { COLOR: #0032c8; FONT-SIZE: 12px; FONT-WEIGHT: bold } .menu-link { TEXT-ALIGN: center; FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: = #0000c0; FONT-SIZE: 13px; FONT-WEIGHT: bold; TEXT-DECORATION: none } A.menu-link:visited { TEXT-ALIGN: center; FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: = #0000c0; FONT-SIZE: 13px; FONT-WEIGHT: bold; TEXT-DECORATION: none } .menu-curr-page { TEXT-ALIGN: center; FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: = #ffffff; FONT-SIZE: 13px; FONT-WEIGHT: bold } A.menu-link:hover { COLOR: #ffffff; TEXT-DECORATION: none } .header-link { FONT-FAMILY: Arial, sans-serif; COLOR: #0055aa; FONT-SIZE: 110%; = FONT-WEIGHT: bold } .inpage-link { COLOR: #004080 } .sans75 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .sans80 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80% } .sans80b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .sans90 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 90% } .sans90b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 90%; FONT-WEIGHT: bold } .sans { FONT-FAMILY: Arial, sans-serif } .sans105b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 105%; FONT-WEIGHT: bold } .sans125b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 125%; FONT-WEIGHT: bold } .msg-error { BACKGROUND: yellow; COLOR: red; FONT-WEIGHT: bold } .msg-warning { BACKGROUND: yellow; COLOR: brown; FONT-WEIGHT: bold } .eqn-image { MARGIN: 5px } A.navlink { COLOR: #0055aa; TEXT-DECORATION: none } A.navlink:hover { BACKGROUND-COLOR: #ccd8e4; COLOR: #0055aa; TEXT-DECORATION: none } .navlink-box { BORDER-BOTTOM: #cccccc 6px solid; PADDING-BOTTOM: 2px; WIDTH: 675px; = FONT-FAMILY: tahoma, verdana, Arial, sans-serif; FONT-SIZE: 80%; = FONT-WEIGHT: bold; PADDING-TOP: 2px } .navlink-box-black { BORDER-BOTTOM: #000000 6px solid } .navlink-box-brtblue { BORDER-BOTTOM: #649afc 6px solid } .navlink-box-dkgreen { BORDER-BOTTOM: #006666 6px solid } .navlink-box-gray { BORDER-BOTTOM: #cccecc 6px solid } .navlink-box-green { BORDER-BOTTOM: #dce6e4 6px solid } .navlink-box-ltblue { BORDER-BOTTOM: #9ccefc 6px solid } .navlink-box-slateblue { BORDER-BOTTOM: #6c9acc 6px solid } .navlink-box-teal { BORDER-BOTTOM: #9ccecc 6px solid } .navlink-box-navy { BORDER-BOTTOM: #003399 6px solid } .navlink-box-bcwm-combo-blue { BORDER-BOTTOM: #639ace 3px solid } .fm-related-articles { BORDER-BOTTOM: #666699 1px solid; BORDER-LEFT: #666699 1px solid; = PADDING-BOTTOM: 5px; LINE-HEIGHT: 140%; PADDING-LEFT: 5px; = PADDING-RIGHT: 5px; MARGIN-LEFT: 10px; BORDER-TOP: #ccd8e4 1px solid; = MARGIN-RIGHT: 15px; BORDER-RIGHT: #ccd8e4 1px solid; PADDING-TOP: 5px } .nihms-highlight { TEXT-ALIGN: center; MARGIN: 0px 0.2em 0px 0px; WIDTH: 4em; BACKGROUND: = yellow; FLOAT: left; COLOR: #990000; FONT-SIZE: 0.8em; FONT-WEIGHT: bold } .retraction-notice { COLOR: red; FONT-SIZE: 1.2em; FONT-WEIGHT: bold } .retraction-notice A { COLOR: red } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TR[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TD[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TABLE.rendered TD { PADDING-BOTTOM: 0.2em; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0.2em } TABLE.rendered TH { PADDING-BOTTOM: 0.2em; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0.2em } TABLE.rendered TD { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'top'] { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'middle'] { VERTICAL-ALIGN: middle } TABLE.rendered TD[valign=3D'bottom'] { VERTICAL-ALIGN: bottom } .head1 { FONT-SIZE: 120% } .head2 { FONT-SIZE: 110% } .head3 { FONT-SIZE: 105% } .head4 { FONT-SIZE: 99% } .head5 { FONT-SIZE: 90% } .acknowledgment-journal-title { FONT-STYLE: italic } DIV.exception-box { BORDER-BOTTOM: silver 1px dashed; BORDER-LEFT: silver 1px dashed; = PADDING-BOTTOM: 0.3em; PADDING-LEFT: 0.3em; PADDING-RIGHT: 0.3em; = MARGIN-BOTTOM: 1.31em; FONT-SIZE: 0.87em; BORDER-TOP: silver 1px dashed; = BORDER-RIGHT: silver 1px dashed; PADDING-TOP: 0.3em } DIV.exception-box .front-matter-section { FONT-SIZE: 1.14em } DIV.p { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-first { MARGIN-TOP: 0px } DIV.sec-first { MARGIN-TOP: 0px } DIV.p-last { MARGIN-BOTTOM: 0px } DIV.sec-last { MARGIN-BOTTOM: 0px } DIV.p-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } DIV.sec-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } SUP { LINE-HEIGHT: 0.8em; WHITE-SPACE: nowrap; FONT-SIZE: 0.8em } SUB { LINE-HEIGHT: 0.8em; WHITE-SPACE: nowrap; FONT-SIZE: 0.8em } .footnote-char { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-ec { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.3em } ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbase1.css BODY { BACKGROUND-COLOR: #f8f8f8 } .small-caps { FONT-VARIANT: small-caps; FONT-SIZE: 80% } .monospace { FONT-FAMILY: monospace } .pmctop-bg { BACKGROUND-COLOR: #fffeee } A.pmctop { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 12px; = TEXT-DECORATION: none } .pmc-body A:active { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-table A:active { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-table A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-figure A:active { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-figure A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body A:hover { BACKGROUND-COLOR: #ccd8e4 } .pmc-body-table A:hover { BACKGROUND-COLOR: #ccd8e4 } .pmc-body-figure A:hover { BACKGROUND-COLOR: #ccd8e4 } HR { COLOR: #0072a8 } .base-highlight1 { BACKGROUND-COLOR: #ebebeb } .base-highlight2 { BACKGROUND-COLOR: #cccccc } .controls { FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: #000000; FONT-SIZE: = 75%; FONT-WEIGHT: bold; TEXT-DECORATION: none } .formtext { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80% } .link { COLOR: #0055aa; TEXT-DECORATION: none } .footer-link { TEXT-ALIGN: center; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80% } .side-head { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 90%; FONT-WEIGHT: bold } .side-subhead { MARGIN-TOP: 10px; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75%; = FONT-WEIGHT: bold } .side-item { BORDER-BOTTOM: #c0c0c0 1px solid; PADDING-BOTTOM: 2px; MARGIN: 2px 1px = 2px 4px; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .side-curr-item { BORDER-BOTTOM: #c0c0c0 1px solid; PADDING-BOTTOM: 2px; MARGIN: 2px 1px = 2px 4px; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .side-item A { COLOR: #0055aa; TEXT-DECORATION: none } .side-curr-item { COLOR: #808080 } .toc-header-vid { LINE-HEIGHT: 1.1em; MARGIN-TOP: 1.1em; FONT-FAMILY: Arial, sans-serif; = MARGIN-BOTTOM: 1.1em; FONT-SIZE: 120%; FONT-WEIGHT: bold } .more-iss-text { MARGIN-TOP: 1.35em; FONT-FAMILY: Arial, sans-serif; MARGIN-BOTTOM: = 1.35em; FONT-WEIGHT: bold } .more-iss-link { COLOR: #0055aa; TEXT-DECORATION: none } .arc-issue { TEXT-ALIGN: center; FONT-FAMILY: Arial, sans-serif; COLOR: #004080; = FONT-SIZE: 80%; TEXT-DECORATION: none } .toc-entry { LINE-HEIGHT: 1.12em } .toc-comment { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 70% } .toc-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .toc-author { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-cit-jour { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif; COLOR: #666666; = FONT-SIZE: 75% } .toc-cit-vol { FONT-FAMILY: Arial, sans-serif; COLOR: #666666; FONT-SIZE: 75% } .toc-cit-page { FONT-FAMILY: Arial, sans-serif; COLOR: #666666; FONT-SIZE: 75%; = FONT-WEIGHT: bold } .toc-cit-date { FONT-FAMILY: Arial, sans-serif; WHITE-SPACE: nowrap; COLOR: #666666; = FONT-SIZE: 75% } .toc-pmcid { FONT-FAMILY: Arial, sans-serif; WHITE-SPACE: nowrap; COLOR: #666666; = FONT-SIZE: 75% } .toc-link { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .toc-divider { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75%; TEXT-DECORATION: none } .toc-corrected-citation { MARGIN-LEFT: 1em } .toc-corrected-prefix { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-1st-author-etal { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-citation-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-prefix { FONT-WEIGHT: 600 } .toc-corrected-citation-info { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-citation-info .citation-abbreviation { FONT-STYLE: italic } .toc-entry-abstract-toc { PADDING-BOTTOM: 0px; PADDING-LEFT: 2em; PADDING-RIGHT: 2em; = FONT-FAMILY: Arial, san-serif; COLOR: #333; FONT-SIZE: 75%; PADDING-TOP: = 0px } .cited-article-fm { BORDER-BOTTOM: 1px solid; BORDER-LEFT: 1px solid; BACKGROUND-COLOR: = #ebebeb; PADDING-LEFT: 8px; PADDING-RIGHT: 8px; MARGIN-LEFT: 0px; = BORDER-TOP: 1px solid; BORDER-RIGHT: 1px solid } .citing-article-fm { PADDING-LEFT: 8px; PADDING-RIGHT: 8px; MARGIN-LEFT: 0px } .sidefm-pmchead { FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: #0055aa; FONT-SIZE: = 85%; FONT-WEIGHT: bold; TEXT-DECORATION: none } .sidefm-pmhead { FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: #0055aa; FONT-SIZE: = 85%; FONT-WEIGHT: bold; TEXT-DECORATION: none } .sidefm-pmsubhead { MARGIN-TOP: 10px; FONT-FAMILY: Arial, sans-serif; COLOR: #000000; = FONT-SIZE: 75%; FONT-WEIGHT: bold } .sidefm-pmclink { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .sidefm-pmart { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .side-section { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .side-caption { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .figure-table-caption-in-article { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .figure-table-caption-in-article { LINE-HEIGHT: 1.5em; COLOR: #000000 } .sidefm-pmclink-item { PADDING-LEFT: 10px } .sidefm-pmclink-item A { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmccurrent-item A { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmclink-item A:hover { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmccurrent-item A:hover { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmclink-item A { COLOR: #004080 } .sidefm-pmclink-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A { COLOR: #808080; CURSOR: default } .sidefm-pmccurrent-item A:hover { COLOR: #808080; CURSOR: default } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #dcdcdc } .side-section-curr { FONT-FAMILY: Arial, sans-serif; COLOR: #808080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .sidebar-cell .sidefm-supplink { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .sidebar-cell .side-supplink { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } A.sidefm-supplink { COLOR: #b55a00; TEXT-DECORATION: none } A.side-supplink { COLOR: #b55a00; TEXT-DECORATION: none } .side-section-group { LINE-HEIGHT: 100%; PADDING-LEFT: 3px; PADDING-RIGHT: 3px; BORDER-TOP: = #0077aa 1px solid; TEXT-DECORATION: none } .head-separate { MARGIN-BOTTOM: 1.2em } .links-box { BORDER-BOTTOM: #666699 1px solid; BORDER-LEFT: #666699 1px solid; = PADDING-BOTTOM: 5px; MARGIN: 1.5em 15px 1.5em 10px; PADDING-LEFT: 5px; = PADDING-RIGHT: 5px; BORDER-TOP: #ccd8e4 1px solid; BORDER-RIGHT: #ccd8e4 = 1px solid; PADDING-TOP: 5px } :unknown { BORDER-BOTTOM: #336699 1px dotted; BORDER-LEFT: #336699 1px dotted; = BORDER-TOP: #336699 1px dotted; BORDER-RIGHT: #336699 1px dotted } .main-table-content { MARGIN-LEFT: 9px } .main-figure-content { MARGIN-LEFT: 9px } .fm-copyright { MARGIN-TOP: 16px; MARGIN-BOTTOM: 16px } .fm-author { MARGIN-TOP: 16px; MARGIN-BOTTOM: 16px } .fm-affl { MARGIN-TOP: 16px; MARGIN-BOTTOM: 12px; FONT-WEIGHT: normal } .fm-footnote { MARGIN-TOP: 12px; MARGIN-BOTTOM: 12px } .fm-pubdate { MARGIN-TOP: 12px; MARGIN-BOTTOM: 12px } .fm-citation { MARGIN-TOP: 0px } .fm-citation-ids { TEXT-ALIGN: right; PADDING-LEFT: 1em; FONT-FAMILY: Arial,sans-serif; = WHITE-SPACE: nowrap; FONT-SIZE: 85% } .fm-citation-ids-label { COLOR: #666 } .fm-citation-pmcid { =09 } .fm-citation-manuscriptid { =09 } .fm-copyright { MARGIN-TOP: 6px } .links-box .fm-footnote { MARGIN: 0px } .tocentry { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-LEFT: 2.5em } .toc-entry-alt-lang-msg { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .portal-tocentry { MARGIN-TOP: 1.6ex; MARGIN-BOTTOM: 2ex; MARGIN-RIGHT: 1em } .button-elsevierwt { BORDER-RIGHT-WIDTH: 0px; BORDER-TOP-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-LEFT-WIDTH: 0px } .elsevierwt-sponsored-label { COLOR: #f8f8f8; FONT-WEIGHT: 600 } .banner-journal-publisher-over-image-elsevierwt { POSITION: relative; LINE-HEIGHT: 1.5em; FONT-FAMILY: Georgia, "Times = New Roman", Times, serif; HEIGHT: 75px; COLOR: #9a7947; MARGIN-LEFT: = 20px; OVERFLOW: hidden; TOP: -30px; MARGIN-RIGHT: 145px } .banner-journal-name-elsevierwt { COLOR: #954a4a; MARGIN-LEFT: 1em; FONT-SIZE: 1.2em; FONT-WEIGHT: 600 } A.elsevierwt-button-link { POSITION: relative; TOP: 40px; LEFT: 360px } A.elsevierwt-button-link:hover { BACKGROUND-COLOR: #f1e8ce } .fm-elsevierwt-disclaimer { MARGIN-TOP: 12px; FONT-FAMILY: Arial, sans-serif; MARGIN-BOTTOM: 12px; = FONT-SIZE: 0.68em } .ref-cit-blk { LINE-HEIGHT: 1.4em; MARGIN-TOP: 1.4em } .back-ref-list-1st-line-shifted LI { LINE-HEIGHT: 1.4em; MARGIN-TOP: 1.4em } .back-ref-list LI { LINE-HEIGHT: 1.4em; MARGIN-TOP: 1.4em } DIV.ref-label { BORDER-BOTTOM: #f8f8f8 1px solid; TEXT-ALIGN: right; BORDER-LEFT: = #f8f8f8 1px solid; WIDTH: 45px; FLOAT: left; BORDER-TOP: #f8f8f8 1px = solid; BORDER-RIGHT: #f8f8f8 1px solid } DIV.ref-cit { MARGIN-LEFT: 55px } SPAN.ref-label { FONT-STYLE: italic } SPAN.ref-cit { =09 } .back-ref-list-1st-line-shifted LI { LIST-STYLE-TYPE: none; TEXT-INDENT: -1.5em; PADDING-LEFT: 1.5em; = MARGIN-LEFT: 2em } .array-table { LINE-HEIGHT: 1.31em; BACKGROUND-COLOR: #f4f4f4; MARGIN-TOP: 1em; WIDTH: = 100%; MARGIN-BOTTOM: 1em } .array-table-inline { LINE-HEIGHT: 1.31em; BACKGROUND-COLOR: #f4f4f4; MARGIN-TOP: 1em; WIDTH: = 100%; MARGIN-BOTTOM: 1em } .array-table TD { PADDING-BOTTOM: 0em; PADDING-LEFT: 0.5em; PADDING-RIGHT: 0.5em; = PADDING-TOP: 0em } .array-table-inline { DISPLAY: inline } .list-item-w-pw { BORDER-BOTTOM: #f8f8f8 1px solid; BORDER-LEFT: #f8f8f8 1px solid; = BORDER-TOP: #f8f8f8 1px solid; BORDER-RIGHT: #f8f8f8 1px solid } .list-item-w-pw-prefix-word { POSITION: relative; TEXT-ALIGN: right; DISPLAY: inline-block } .list-item-w-pw-content { POSITION: relative; TOP: -1.35em } .list-item-p-question { FONT-WEIGHT: bold } SPAN.underline { BORDER-BOTTOM: black 1px solid } SPAN.double-underline { BORDER-BOTTOM: black 3px double } SPAN.bold-double-underline { BORDER-BOTTOM: black 3px double } .verse-group { LINE-HEIGHT: 1.16em; MARGIN: 1.31em 2em; FONT-FAMILY: "Monotype = Corsiva", "Apple Chancery", "URW Chancery L", cursive; FONT-SIZE: 1.12em } .internal-control { PADDING-BOTTOM: 0.5em; BACKGROUND-COLOR: #f0f0f0; MARGIN: 1.5em auto; = PADDING-LEFT: 0.5em; WIDTH: 95%; PADDING-RIGHT: 0.5em; FONT-WEIGHT: = bold; PADDING-TOP: 0.5em } .sidebar-menu-square-image-holder { PADDING-RIGHT: 0.35em; VERTICAL-ALIGN: middle; _padding-top: 0.35em } DIV.figure-role { MARGIN: 1em 0px } DIV.signature { MARGIN: 1.8em 0px; FONT-FAMILY: "Monotype Corsiva", "Apple Chancery", = "URW Chancery L", cursive } DIV.simple-list-item-w-label { TEXT-INDENT: -2em; FLOAT: left } .selective-deposit-msg { BORDER-BOTTOM: #f4f4f4 0.5em solid; BORDER-LEFT: #f4f4f4 0.5em solid; = BACKGROUND-COLOR: #f4f4f4; FONT-FAMILY: Arial,sans-serif; FONT-SIZE: = 80%; BORDER-TOP: #f4f4f4 0.5em solid; BORDER-RIGHT: #f4f4f4 0.5em solid } .fm-title { MARGIN-TOP: 16px } .fm-trans-title { MARGIN-TOP: 16px } .ukpmc-tocentry-icon { BORDER-RIGHT-WIDTH: 0px; BORDER-TOP-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: text-bottom; BORDER-LEFT-WIDTH: 0px; MARGIN-RIGHT: = 0.25em } ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbars-slateblue.css .doc-group1 { BACKGROUND-COLOR: #0072a8; FONT-FAMILY: Verdana, sans-serif; COLOR: = white; FONT-SIZE: 110%; FONT-WEIGHT: bold } .doc-group2 { TEXT-ALIGN: center; BACKGROUND-COLOR: #cccccc; FONT-FAMILY: Arial, = sans-serif; COLOR: #004080; FONT-WEIGHT: bold } .doc-group3 { TEXT-ALIGN: center; BACKGROUND-COLOR: #cccccc; FONT-FAMILY: Arial, = sans-serif; COLOR: #000000; FONT-WEIGHT: bold } .doc-group4 { =09 } .toc-supp-link { FONT-FAMILY: Arial, sans-serif; COLOR: #e64a00; FONT-SIZE: 75%; = TEXT-DECORATION: none } .toc-highlight1 { BACKGROUND-COLOR: #ffffd0 } .toc-highlight2 { BACKGROUND-COLOR: #ace4ff } .head1 { BORDER-BOTTOM: #0072a8 1pt solid; TEXT-ALIGN: center; BORDER-LEFT: = #0072a8 1pt solid; BACKGROUND-COLOR: #0072a8; FONT-FAMILY: Verdana, = sans-serif; COLOR: white; FONT-SIZE: 110%; BORDER-TOP: #0072a8 1pt = solid; FONT-WEIGHT: bold; BORDER-RIGHT: #0072a8 1pt solid } .head1A { BACKGROUND-COLOR: #cccccc; FONT-FAMILY: Arial, sans-serif; COLOR: = #004080; FONT-WEIGHT: bold } .append-head1 { TEXT-ALIGN: center; FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .colorbar-link { COLOR: #ffffff } .head1 A:link { COLOR: white } .head1 A:visited { COLOR: white } .head1A A:link { COLOR: white } .head1A A:visited { COLOR: white } ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbody4.css .fm-vol-iss-date { TEXT-ALIGN: left; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-citation { TEXT-ALIGN: left; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-citation-ids { FONT-SIZE: 75% } .fm-citation .fm-vol-iss-date { FONT-SIZE: 100% } .pubnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75%; FONT-WEIGHT: bold } .pubnote-hilite { BACKGROUND-COLOR: #ebebeb; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: = 75% } .fm-dochead { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .fm-doctopic { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-docsubject { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-ser-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .fm-supp-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .fm-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 125%; FONT-WEIGHT: bold } .fm-subtitle { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .fm-trans-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 120% } .fm-trans-subtitle { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 105% } .fm-author { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 110% } .fm-affl { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-pubdate { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-editor { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-footnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-author .fm-footnote { FONT-SIZE: 68.5% } .fm-author .fm-affl { FONT-SIZE: 68.5% } .fm-author .fm-footnote .fm-affl { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 100% } .fm-editor .fm-footnote .fm-affl { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 100% } .fm-editor .fm-footnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 100% } .fm-role { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif } .fm-copyright { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .pmcnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 85% } .abs-head2 { =09 } .abs-head2 { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .kwd-label { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .abs-head3 { FONT-FAMILY: Arial, sans-serif } .head2 { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .head3 { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif } .head4 { FONT-FAMILY: Arial, sans-serif } .head5 { =09 } .kwd-text { FONT-SIZE: 85% } .eqn-image { TEXT-ALIGN: center } .eqn-id { TEXT-ALIGN: right; FONT-WEIGHT: bold } .box { BORDER-BOTTOM: #607080 1px solid; BORDER-LEFT: #607080 1px solid; = BACKGROUND-COLOR: #e4e8ec; OVERFLOW: auto; BORDER-TOP: #607080 1px = solid; BORDER-RIGHT: #607080 1px solid } .boxhead1 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 105%; FONT-WEIGHT: bold } .boxhead2 { FONT-WEIGHT: bold } A.cite-reflink { COLOR: #0050a0 } .fig-table-link { COLOR: #0050a0 } A.int-reflink { COLOR: #0050a0 } A.ext-reflink { COLOR: #0050a0 } .figwind-cite { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .figwind-copyrt { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .product-source { FONT-STYLE: italic } .signature-group { FONT-STYLE: italic; MARGIN-LEFT: 2em; FONT-WEIGHT: bold } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcrefs5.css .ref-id { } .ref-title { } .ref-author { } .ref-journal { } .ref-pubdate { } .ref-vol { } .ref-iss { } .ref-page { } .ref-edition { } .ref-editor { } .ref-pubname { } .ref-publoc { } .ref-extlink { COLOR: #0050a0 } ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/jsutils/css/tileshop_pmc.1/tileshop_pmc.1.css .viewport { -moz-user-select: none; -khtml-user-select: none; user-select: none } .viewport-static-image { -moz-user-select: none; -khtml-user-select: none; user-select: none } .panorama { -moz-user-select: none; -khtml-user-select: none; user-select: none } .scale-pmc { -moz-user-select: none; -khtml-user-select: none; user-select: none } .viewport { FLOAT: left } .viewport-static-image { FLOAT: left } .viewport { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif); = OVERFLOW: hidden } .viewport .dnd { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif) } .dnd { MARGIN-LEFT: auto; CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/grab.cur), move; = MARGIN-RIGHT: auto } .moving { CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/grabbing.cur), move } .viewport-static-image { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc; OVERFLOW: hidden } .viewport-static-image IMG { CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/zoomin.cur), auto } .tileshop { BACKGROUND-COLOR: #fff; FLOAT: left; CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/zoomin.cur), auto } .nodrag { CURSOR: default } .static { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc; CURSOR: default } .static IMG { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc; CURSOR: default } .half-static { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc } .half-static IMG { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc } .tile-fill { BACKGROUND-COLOR: #f0f } .panorama { BORDER-BOTTOM-STYLE: none; BORDER-LEFT: black 1px solid; = BACKGROUND-COLOR: #ecf0f4; BORDER-TOP: black 1px solid; BORDER-RIGHT: = #f0ffff 3px solid } .panorama DIV { OVERFLOW: hidden } .panorama IMG { CURSOR: pointer } .pan-switcher { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/pan_close.gif); = BORDER-BOTTOM: #000 1px solid; BORDER-LEFT: #000 1px solid; = BACKGROUND-COLOR: #fff; WIDTH: 10px; BACKGROUND-REPEAT: no-repeat; = HEIGHT: 10px; BORDER-TOP: #000 1px solid; CURSOR: pointer; BORDER-RIGHT: = #000 1px solid; _background-color: transparent; _border: none } .pan-switcher-close { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/pan_open.gif) } .pan { BORDER-BOTTOM: #000 2px dotted; FILTER: alpha(opacity=3D70); = BORDER-LEFT: #000 2px dotted; BACKGROUND-COLOR: #dce0e4; FONT-SIZE: 1px; = BORDER-TOP: #000 2px dotted; CURSOR: move; BORDER-RIGHT: #000 2px = dotted; opacity: 0.7 } DIV.panel { BORDER-BOTTOM: gray 1px solid; BORDER-LEFT: gray 1px solid; = PADDING-BOTTOM: 0px; BACKGROUND-COLOR: #ecf0f4; MARGIN: 0px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: left; BORDER-TOP: gray 1px = solid; BORDER-RIGHT: gray 1px solid; PADDING-TOP: 0px } DIV.panel P { TEXT-ALIGN: center; PADDING-BOTTOM: 0.2em; BACKGROUND-COLOR: #ecf0f4; = MARGIN: 0px; MIN-HEIGHT: 21px; PADDING-LEFT: 0px; WIDTH: 100%; = PADDING-RIGHT: 0px; FLOAT: left; PADDING-TOP: 0.1em } DIV.panel P SPAN { MARGIN: 0px; PADDING-LEFT: 25px; WIDTH: 85%; FLOAT: left } DIV.panel P A { MIN-HEIGHT: 21px; DISPLAY: none; TEXT-DECORATION: none } DIV.panel P A.active { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/toolbar.png); MARGIN: = 0px 9px 0px 0px; WIDTH: 36px; DISPLAY: block; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 13px 0px; FLOAT: right; HEIGHT: 21px; = _background-image: url(../../img/tileshop_pmc.1/toolbar.gif); = _margin-right: 5px } DIV.panel P A.active:hover { BACKGROUND-COLOR: #ecf0f4; BACKGROUND-REPEAT: no-repeat; = BACKGROUND-POSITION: -67px 0px; TEXT-DECORATION: none } DIV.panel DL { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DD { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DT { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DT IMG { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DL { WIDTH: 100%; FLOAT: left } DIV.panel DL DD { FLOAT: right } DIV.panel DL DT { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif); FLOAT: = left } .scale-pmc { MARGIN: auto; WIDTH: 32px; PADDING-TOP: 0em } .scale-pmc A { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/toolbar.png); = PADDING-BOTTOM: 1px; MARGIN: 0px; PADDING-LEFT: 1px; PADDING-RIGHT: 1px; = DISPLAY: block; BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; FONT-SIZE: = 3px; TEXT-DECORATION: none; PADDING-TOP: 1px; _background-image: = url(../../img/tileshop_pmc.1/toolbar.gif) } .scale-pmc A:hover { BACKGROUND-COLOR: transparent; BACKGROUND-REPEAT: no-repeat; = TEXT-DECORATION: none } .scale-pmc A.scale-up { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-up-disabled { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-down-disabled { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-down { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-up { BACKGROUND-POSITION: 4px -26px } .scale-pmc A.scale-up:hover { BACKGROUND-POSITION: -76px -26px } .scale-pmc A.scale-up-disabled { BACKGROUND-POSITION: -36px -26px; CURSOR: default } .scale-pmc A.scale-down { BACKGROUND-POSITION: 4px -226px } .scale-pmc A.scale-down:hover { BACKGROUND-POSITION: -76px -226px } .scale-pmc A.scale-down-disabled { BACKGROUND-POSITION: -36px -226px; CURSOR: default } .scale-pmc A.scale-1 { BACKGROUND-POSITION: 3px -57px } .scale-pmc A.scale-1:hover { BACKGROUND-POSITION: -77px -57px } .scale-pmc A.selected-1 { BACKGROUND-POSITION: -37px -57px; CURSOR: default } .scale-pmc A.selected-1:hover { BACKGROUND-POSITION: -37px -57px; CURSOR: default } .scale-pmc A.scale-2 { BACKGROUND-POSITION: 3px -77px } .scale-pmc A.scale-2:hover { BACKGROUND-POSITION: -77px -77px } .scale-pmc A.selected-2 { BACKGROUND-POSITION: -37px -77px; CURSOR: default } .scale-pmc A.selected-2:hover { BACKGROUND-POSITION: -37px -77px; CURSOR: default } .scale-pmc A.scale-3 { BACKGROUND-POSITION: 3px -97px } .scale-pmc A.scale-3:hover { BACKGROUND-POSITION: -77px -97px } .scale-pmc A.selected-3 { BACKGROUND-POSITION: -37px -97px; CURSOR: default } .scale-pmc A.selected-3:hover { BACKGROUND-POSITION: -37px -97px; CURSOR: default } .scale-pmc A.scale-4 { BACKGROUND-POSITION: 3px -117px } .scale-pmc A.scale-4:hover { BACKGROUND-POSITION: -77px -117px } .scale-pmc A.selected-4 { BACKGROUND-POSITION: -37px -117px; CURSOR: default } .scale-pmc A.selected-4:hover { BACKGROUND-POSITION: -37px -117px; CURSOR: default } .scale-pmc A.scale-5 { BACKGROUND-POSITION: 3px -137px } .scale-pmc A.scale-5:hover { BACKGROUND-POSITION: -77px -137px } .scale-pmc A.selected-5 { BACKGROUND-POSITION: -37px -137px; CURSOR: default } .scale-pmc A.selected-5:hover { BACKGROUND-POSITION: -37px -137px; CURSOR: default } .scale-pmc A.scale-6 { BACKGROUND-POSITION: 3px -157px } .scale-pmc A.scale-6:hover { BACKGROUND-POSITION: -77px -157px } .scale-pmc A.selected-6 { BACKGROUND-POSITION: -37px -157px; CURSOR: default } .scale-pmc A.selected-6:hover { BACKGROUND-POSITION: -37px -157px; CURSOR: default } .scale-pmc A.scale-7 { BACKGROUND-POSITION: 3px -177px } .scale-pmc A.scale-7:hover { BACKGROUND-POSITION: -77px -177px } .scale-pmc A.selected-7 { BACKGROUND-POSITION: -37px -177px; CURSOR: default } .scale-pmc A.selected-7:hover { BACKGROUND-POSITION: -37px -177px; CURSOR: default } .scale-pmc A.scale-8 { BACKGROUND-POSITION: 3px -207px } .scale-pmc A.scale-8:hover { BACKGROUND-POSITION: -77px -207px } .scale-pmc A.selected-8 { BACKGROUND-POSITION: -37px -207px; CURSOR: default } .scale-pmc A.selected-8:hover { BACKGROUND-POSITION: -37px -207px; CURSOR: default } ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/js/common.js // Called from many places to handle links.=0A= // Params:=0A= // link: URL. 'this' to reuse same window, else ""=0A= // windowname: Reference name for window=0A= // additional: Attributes for window.open, from:=0A= // width, height, resizable, scrollbars, toolbar, location, = directories,=0A= // status, menubar, copyhistory.=0A= // Notes: Book version always provides menubar, toolbar, etc.=0A= //=0A= function startTargetBook(link,windowname,width,height,additional)=0A= {=0A= startTarget(link,windowname,width,height,additional)=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function startTarget(link,windowname,width,height, additional)=0A= {=0A= if(! window.focus)=0A= return;=0A= =0A= var sizestring =3D ",width=3D" + width + ",height=3D" + height;=0A= var opt =3D = "menubar=3Dno,toolbar=3Dno,status=3Dno,scrollbars=3Dyes,resizable=3Dyes,d= ependent=3Dyes,location=3Dno";=0A= var allOptions =3D opt + sizestring;=0A= if (additional) { allOptions =3D allOptions + ',' + additional; }=0A= =0A= windowname =3D String(windowname).replace(/-/g, "_")=0A= var moveToXDefault =3D 75=0A= var moveToYDefault =3D 50=0A= =0A= var moveToX =3D moveToXDefault=0A= var moveToY =3D moveToYDefault=0A= var yAdj =3D 50=0A= var yAdjDelta =3D 25=0A= =0A= var barNames =3D ['menubar', 'toolbar', 'statusbar']=0A= for (var idx in barNames)=0A= { =0A= if (String(allOptions).lastIndexOf(barNames[idx] + '=3Dyes') > =0A= String(allOptions).lastIndexOf(barNames[idx] + '=3Dno'))=0A= yAdj +=3D yAdjDelta=0A= }=0A= =0A= try {=0A= if (window.screen.width && width > 0)=0A= moveToX =3D Math.ceil((window.screen.width - width)) - 15=0A= moveToX =3D (moveToX > 0 ? moveToX : moveToXDefault)=0A= =0A= if (window.screen.height && height > 0)=0A= moveToY =3D Math.ceil((window.screen.height - height)) - yAdj=0A= moveToY =3D (moveToY > 0 ? moveToY : moveToYDefault)=0A= }=0A= catch (e) {}=0A= =0A= var wLeftTopCornerOptions =3D ',left=3D' + moveToX + ',top=3D' + = moveToY + ',screenX=3D' + moveToX + ',screenY=3D' + moveToY=0A= =0A= allOptions =3D allOptions + wLeftTopCornerOptions=0A= =0A= w =3D window.open ("", windowname, allOptions)=0A= w.focus()=0A= =0A= link.target=3Dwindowname=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function focuswin(windowname)=0A= {=0A= windowname =3D String(windowname).replace(/-/g, "_")=0A= w =3D = window.open("",windowname,"menubar=3Dyes,scrollbars=3Dyes,toolbar=3Dyes,l= ocation=3Dyes,status=3Dyes,directories=3Dyes,resizable=3Dyes");=0A= w.focus();=0A= =0A= return true;=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function reverseString (inStr)=0A= {=0A= var outStr =3D ''=0A= =0A= for (i =3D0; i <=3D inStr.length; i++)=0A= {=0A= outStr =3D inStr.charAt(i) + outStr=0A= }=0A= =0A= return outStr=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function reverseAndReplaceString (inStr, findStr, newStr)=0A= {=0A= return reverseString(inStr).replace(findStr, newStr)=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function initUnObscureEmail (className, innerHTML)=0A= {=0A= =0A= try{=0A= if (window.addEventListener)=0A= window.addEventListener('load', function() {unObscureEmail = (className, innerHTML)}, false)=0A= else if (window.attachEvent)=0A= window.attachEvent('onload', function() {unObscureEmail = (className, innerHTML)})=0A= }catch(e){=0A= }=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function unObscureEmail (className, innerHTML)=0A= {=0A= try {=0A= if (typeof(unObscuredEmails) =3D=3D 'undefined')=0A= unObscuredEmails =3D new Array()=0A= =0A= if (! unObscuredEmails[className])=0A= {=0A= =0A= var elmnts =3D document.getElementsByTagName("span")=0A= for (var i =3D 0, len =3D elmnts.length; i < len; i++)=0A= {=0A= if (elmnts.item(i).className.indexOf(className, " ") = !=3D -1)=0A= {=0A= elmnts.item(i).innerHTML =3D innerHTML;=0A= unObscuredEmails[className] =3D true=0A= =0A= }=0A= }=0A= }=0A= }=0A= catch(e){=0A= }=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function pubMedDbLinkSubmit(control) {=0A= try{=0A= if (control.pubmedOption)=0A= control =3D control.pubmedOption=0A= if (control.options)=0A= location.href =3D = control.options[control.options.selectedIndex].value;=0A= }=0A= catch(e){}=0A= return false;=0A= }=0A= ------=_NextPart_000_0000_01C98BAF.180554B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/jsutils/utils.1.js // = /web/private/htdocs/staff/sponomar/TEST/corehtml/jsutils/utils.1.js.orig=0A= =0A= var = utils=3D{KeyCode_TAB:9,KeyCode_DELETE:46,KeyCode_BACKSPACE:8,KeyCode_LEFT= _ARROW:37,KeyCode_RIGHT_ARROW:39,KeyCode_HOME:36,KeyCode_END:35,KeyCode_P= AGE_UP:33,KeyCode_PAGE_DOWN:34,KeyCode_UP_ARROW:38,KeyCode_DOWN_ARROW:40,= KeyCode_ESC:27,KeyCode_ENTER:13,KeyCode_SPACE:32,KeyCode_SHIFT_KEY:16,Key= Code_CTRL_KEY:17,KeyCode_ALT_KEY:18,KeyCode_LEFT_MS_WINDOWS_KEY:91,KeyCod= e_RIGHT_MS_WINDOWS_KEY:92,KeyCode_MS_MENU_KEY:93,bIsIe:0/*@cc_on+1@*/,isO= bject:function(a){return(a&&typeof = a=3D=3D'object');},isArray:function(a){return = this.isObject(a)&&a.constructor=3D=3DArray;},getParent:function(obj){if(o= bj){var = result=3Dobj.parentNode;while(result&&result.nodeType!=3D1)result=3Dresul= t.nextSibling;if(result)return result;}=0A= return null;},getFirstChild:function(obj){if(obj){var = result=3Dobj.firstChild;while(result&&result.nodeType!=3D1)result=3Dresul= t.nextSibling;if(result)return result;}=0A= return null;},getNextSibling:function(obj,tagName){if(obj){var = result=3Dobj.nextSibling;if(tagName){var = tn=3DtagName.toUpperCase();while(result&&result.tagName!=3Dtn)result=3Dre= sult.nextSibling;}else{while(result&&result.nodeType!=3D1)result=3Dresult= .nextSibling;}=0A= return result;}=0A= return null;},getPreviousSibling:function(obj,tagName){if(obj){var = result=3Dobj.previousSibling;if(tagName){var = tn=3DtagName.toUpperCase();while(result&&result.tagName!=3Dtn)result=3Dre= sult.previousSibling;}else{while(result&&result.nodeType!=3D1)result=3Dre= sult.previousSibling;}=0A= return result;}=0A= return null;},nextItem:function(item,nodeName){if(item=3D=3Dnull)return = null;var = next=3Ditem.nextSibling;while(next!=3Dnull){if(next.nodeName=3D=3DnodeNam= e)return next;next=3Dnext.nextSibling;}=0A= return null;},previousItem:function(item,nodeName){var = previous=3Ditem.previousSibling;while(previous!=3Dnull){if(previous.nodeN= ame=3D=3DnodeName)return previous;previous=3Dprevious.previousSibling;}=0A= return null},moveBefore:function(item1,item2){var = parent=3Ditem1.parentNode;parent.removeChild(item1);parent.insertBefore(i= tem1,item2);},moveAfter:function(item1,item2){var = parent=3Ditem1.parentNode;parent.removeChild(item1);parent.insertBefore(i= tem1,item2?item2.nextSibling:null);},insertAfter:function(parent,node,ref= erenceNode){parent.insertBefore(node,referenceNode.nextSibling);},removeC= hildren:function(oObj){if(!oObj||typeof = oObj!=3D"object")return;while(oObj&&oObj.hasChildNodes()){this.removeAllC= hildren(oObj.firstChild);oObj.removeChild(oObj.firstChild);}},removeAllCh= ildren:function(oObj){this.removeChildren(oObj);},getTextContent:function= (x){/*@cc_on return x.text;@*/return = x.textContent;},createCookie:function(name,value,days,path){if(days){var = date=3Dnew Date();date.setTime(date.getTime()+(days*24*60*60*1000));var = expires=3D'; expires=3D'+date.toGMTString();}else = expires=3D'';document.cookie=3Dname+'=3D'+value+expires+'; = path=3D'+(path?path:"/");},readCookie:function(name){var = nameEQ=3Dname+'=3D';var ca=3Ddocument.cookie.split(';');for(var = i=3D0;itest2){dim.w=3DparseInt(x.scrol= lWidth);dim.h=3Dtest1;}else{dim.w=3DparseInt(x.offsetWidth);dim.h=3Dtest2= ;}=0A= return dim;},getStyle:function(oObj,styleProp){var = res;if(oObj.currentStyle){res=3DoObj.currentStyle[styleProp];}=0A= if(typeof(res)!=3D"string"){if(oObj.style){res=3DoObj.style[styleProp];}=0A= if(typeof(res)!=3D"string"){if(document.defaultView){res=3Ddocument.defau= ltView.getComputedStyle(oObj,null).getPropertyValue(styleProp);}=0A= if(typeof(res)!=3D"string"){return null;}}}=0A= return res;},drawText:function(sText,sId,add){if(!sId)sId=3D"debug";var = obj=3Ddocument.getElementById(sId);if(obj){if(add)=0A= obj.innerHTML=3D"
"+sText;else=0A= obj.innerHTML+=3DsText;}},selectRange:function(oObj,iStart,iLength){if(!(= oObj&&oObj.value))return;if(oObj.createTextRange){var = oRange=3DoObj.createTextRange();oRange.moveStart("character",iStart);oRan= ge.moveEnd("character",iLength-oObj.value.length);oRange.select();}else = if(oObj.setSelectionRange){oObj.setSelectionRange(iStart,iLength);}=0A= oObj.focus();},getSelection:function(){var = text=3D"";if(window.getSelection){text+=3Dwindow.getSelection();}else = if(document.getSelection){text+=3Ddocument.getSelection();}else = if(document.selection){text+=3Ddocument.selection.createRange().text;}=0A= return text;},getPlural:function = x_Plural(iN,sSuffix){if(undefined=3D=3DsSuffix){return(iN>1?"s":"");}else= = if("y"=3D=3DsSuffix){return(iN>1?"ies":"");}else{return(iN>1?sSuffix+"s":= sSuffix);}},getPeriodToString:function(iDelta){var x=3D"Error, cannot = convert '"+iDelta+"'";var = sDir;iDelta=3DparseInt(iDelta);if(iDelta<0){sDir=3D" = before";iDelta=3D-iDelta;}else=0A= sDir=3D" ago";var iS=3DparseInt(iDelta/1000);var = iM,iH,iD;if(iS<60){x=3DiS+" = second"+this.getPlural(iS);}else{iM=3DparseInt(iS/60);if(iM<60){x=3DiM+" = minute"+this.getPlural(iM);}else{iH=3DparseInt(iM/60);if(iH<24){iM=3DiM-i= H*60;x=3DiH+" hour"+this.getPlural(iH)+" and "+iM+" = minute"+this.getPlural(iM);}else{iD=3DparseInt(iH/24);iH-=3DiD*24;x=3DiD+= " day"+this.getPlural(iD)+" and "+iH+" hour"+this.getPlural(iH);}}}=0A= return x+sDir;},isEmail:function(s){var = filter=3D/^([\w-]+(?:\.[\w-]+)*)@((?:[\w-]+\.)*\w[\w-]{0,66})\.([a-z]{2,6= }(?:\.[a-z]{2})?)$/i;return(filter.test(s))},addEvent_guid:1,addEvent:fun= ction(element,type,handler){if(!handler.$$guid)handler.$$guid=3Dthis.addE= vent_guid++;if(!element.events)element.events=3D{};var = handlers=3Delement.events[type];if(!handlers){handlers=3Delement.events[t= ype]=3D{};if(element["on"+type]){handlers[0]=3Delement["on"+type];}}=0A= handlers[handler.$$guid]=3Dhandler;element["on"+type]=3DhandleEvent;funct= ion handleEvent(event){var = returnValue=3Dtrue;event=3Devent||fixEvent(window.event);var = handlers=3Dthis.events[event.type];for(var i in = handlers){this.$$handleEvent=3Dhandlers[i];if(this.$$handleEvent(event)=3D= =3D=3Dfalse){returnValue=3Dfalse;}}=0A= return returnValue;};function = fixEvent(event){event.preventDefault=3DfixEvent.preventDefault;event.stop= Propagation=3DfixEvent.stopPropagation;return = event;};fixEvent.preventDefault=3Dfunction(){this.returnValue=3Dfalse;};f= ixEvent.stopPropagation=3Dfunction(){this.cancelBubble=3Dtrue;};return = handler.$$guid;},removeEvent:function(element,type,handler){if(element.ev= ents&&element.events[type]){delete = element.events[type][handler.$$guid];return handler.$$guid;}=0A= return = null;},preventDefault:function(e){if(e.preventDefault)e.preventDefault();= else = window.event.returnValue=3Dfalse;},getRelatedTarget:function(e){if(!e)var= e=3Dwindow.event;if(e.relatedTarget)return e.relatedTarget;else = if(e.toElement)return e.toElement;else if(e.fromElement)return = e.fromElement;},getTargetObj:function(eEvent){var oTarget;var = e=3DeEvent||window.event;if(e=3D=3Dnull)return = null;if(e.srcElement=3D=3Dnull)oTarget=3De.target;else = oTarget=3De.srcElement;while(oTarget&&oTarget.nodeType!=3D1)oTarget=3DoTa= rget.parentNode;return oTarget;},printObj:function(oObj,iLevel){var = s=3D"";var sIdent=3D"";if(!iLevel)iLevel=3D0;for(var = i=3D0;i";}=0A= return s;},jsLoader:{oLoaded:[],sBase:"",load:function(aScripts){var = oS=3Ddocument.getElementsByTagName("script");for(var = j=3D0;j");this.oLoaded.push(sNewSrc);}}}},inse= rtInHtml:function(text,obj){if(document.all){obj.innerHTML+=3Dtext;}else{= var range=3Ddocument.createRange();range.setStartAfter(obj);var = docFrag=3Drange.createContextualFragment(text);obj.appendChild(docFrag);}= },replaceInHtml:function(text,obj){if(document.all){obj.innerHTML=3Dtext;= }else{while(obj.hasChildNodes())obj.removeChild(obj.firstChild);var = range=3Ddocument.createRange();range.setStartAfter(obj);var = docFrag=3Drange.createContextualFragment(text);obj.appendChild(docFrag);}= }};String.prototype.trimSpaces=3Dfunction(trimMode){var = targetString=3Dthis;var = iPos=3D0;if(!trimMode)trimMode=3D0;if(trimMode=3D=3D0||trimMode=3D=3D1){i= f(targetString.charAt(iPos)=3D=3D" = "){while(targetString.charAt(iPos)=3D=3D" = ")iPos++;targetString=3DtargetString.substr(iPos);}}=0A= iPos=3DtargetString.length-1;if(trimMode=3D=3D0||trimMode=3D=3D2){if(targ= etString.charAt(iPos)=3D=3D" "){while(targetString.charAt(iPos)=3D=3D" = ")iPos--;targetString=3DtargetString.substr(0,iPos+1);}}=0A= return targetString;}=0A= function $(){var elements=3Dnew Array();for(var = i=3D0;i0) {=0A= var W=3DoMetadata.aView[0].W * oThis.fScale;=0A= for = (oThis.iScaleIndex=3D0;oThis.iScaleIndex