From: Subject: Wiley InterScience :: Article :: HTML Full Text Date: Sat, 7 Mar 2009 10:23:18 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="multipart/alternative"; boundary="----=_NextPart_000_0000_01C99F0E.BB8D06B0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: multipart/alternative; boundary="----=_NextPart_001_0001_01C99F0E.BB8F77B0" ------=_NextPart_001_0001_01C99F0E.BB8F77B0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/HTMLSTART Wiley = InterScience :: Article :: HTML Full Text ------=_NextPart_001_0001_01C99F0E.BB8F77B0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/blank.html UNTITLED_PAGE= ------=_NextPart_001_0001_01C99F0E.BB8F77B0-- ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/jpeg Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/logo.wiley.526x59.jpg /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAARgAA/+4ADkFkb2JlAGTAAAAAAf/b AIQABAMDAwMDBAMDBAYEAwQGBwUEBAUHCAYGBwYGCAoICQkJCQgKCgwMDAwMCgwMDQ0MDBERERER FBQUFBQUFBQUFAEEBQUIBwgPCgoPFA4ODhQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQU FBQUFBQUFBQUFBQUFBQUFBQU/8AAEQgAOwIOAwERAAIRAQMRAf/EALMAAAICAwEBAQAAAAAAAAAA AAMEAgUBBgcACAkBAAMBAQEBAQEAAAAAAAAAAAABAgMEBQYHCBAAAQIEBAIGBQgIAwYHAQAAAQID ABEEBSExEgZBsVFxIjJCB2GBwcIT0VKC0kOTFBWRoSMzU1RVCLM0FvBicpKyRKJzoyRkNXUYEQAC AgEBBwEGBQUAAwAAAAAAARECAxIhMVGRUhMEBUFhgTKSFHHBQlMG8KGx0SKiMxX/2gAMAwEAAhED EQA/ANg81/NrcPmFeqmkt1W7RbOp1lqhoqda2xUoQuYfqO6VKWUhSUKEmxIAatSlfceF6fXDVN/P /j3L+tp8x5fk91tfp4GjU7NYc33cj41fLHp6Ty+3j6VyRaMUtUZTdcz+cro64UE9unSuQ81R1EhN xfDxGFBPbpwXIZTQvy76+PiMIWinBcgooHp95WfSeiAWinBcj34F6XeVw4mEGinBciJoHpd5XHie EAaKcFyIKoXpy1Kz6T0QBopwXICaF6XeVkOJgDRTguQJVC/j21ceJhh26cFyBqon599efzj0QBop wXICaKo+evh4jDDt04LkDVRVHBxeR8RgDRTpXIgaKpn+8Xn849HXALRTpXIh+Dqf4i+HiPywD7dO lciC6GoUMVryPiPywgVKcFyBrt1TPsuLzy1HohQVppwXIEaKrAxW5w8R+WFBWinBcg34SqkP2rmR 8SvliiO3TpXIA5SVWs/tHP8AmV0RLKVKRuXIEaWq/iucPEYRWinBciSaerKcHXMJ+JXyw9pDx4+l cgTtPWpMw85Kcu+ro64HI1jx9K5ACit4uucPGr5YnaPtY+lciKmawiYfdlj41fLD2i7ePpXJAFs1 s/37ufz1dHXBtDt4+lchZbVd/MO8PGr5YW0fbx9K5IVcbr8ZVD3Hxq+WDbxH28fSuSFnE3Cf+Zez /iK6OuDbxDt4+lckKOC4/wAy9w+0X8sT/wBcSu1i6VyQm6bkJ/8Aun+P2i/lg/64j7WLpryQm6q5 A/5t/P8AiL6OuFNuLH2sXTXkhRxy5/zb/D7VfywptxY+1i6a8kKrcun84/x+1X8sE24sOzh6K8kA W7dJ/wCcfz/ir6OuCbcWHZw9FeSAKeuv85UcPtV/LCm3Fh2cPRXkgSn7r/OVHH7VfD1wTbiw7OHo ryQMv3Sf+cqM/wCKvo64JvxYuzh6K8kCNRdP5x/h9qvj64NV+LDs4eivJA1VF0/najj9qvh64Wq/ Fh2cPRXkiC6q5jOtfGP8VfR1war8WPs4uivJEfxd1l/najIfar4+uFqvxfMOzh6K8kDcrrqhM/xt Rx+1X8sS7X4vmUsGF/oryQuqtuqj2q2oOPF1fR1xGq/F8zVYcPRXkiTdZdUpmK2oE5far+WGrX4v mTbDhf6K8kDer7qcDXVBzP71fyxNr34vmVXBh6K8kBNddR/3tRn/ABV9HXEa78XzNOxh6K8kQFfd pgitqeGTq/lha8nF8x9jD0V5Iy5cbwQR+YVMsftnPrQnkydT5hXx8HRX6ULquN2Sf8/U/fOfLGby ZOp8zVePhf6K8kDVeb2MrlVffufWjN5snU+bLXiYOiv0oAu8Xs53KqPW+59aIebL1PmzReJg6K/S j353ff6nV/fufWg72XqfNi+08f8Abr9KMG+X3+p1f37n1oO9l6nzZX2fj/t1+lGPzy+/1Or+/d+t C72XqfNh9n4/7dfpR788vv8AU6v79z60Hfy9T5sPs/H/AG6/Sj357ff6nV/fufWg7+XqfNh9n4/7 dfpRn89vn9Tq/v3PrQ+/k6nzYfZ+P+3X6UZ/Pb5/U6v79z60V38nU+bF9ng/br9KMi+3v+pVX37n 1offydT5sX2eDor9KJi+3v8AqVV9+59aK7+TqfMn7PB0V+lEhfL1/Uar79z60Us2TqfMn7PB0V+l ExfLz/Uan75z60Us1+p8yfs8HRX6UTF8vH9QqfvnPrRfev1PmS/Dw9FfpRP87u8v/sKn75z5Yfev xfMn7PD0V5I+vqS1zlh82PoWjzNQveLtS2Wqp7ZUNutOVyShisCNTaHFHSJjjI5iOa9o2FVTe0sK LaO562gQxdLoqlr2KgqaqKQyDjUhg4nsg+iM4cbWGpew2AbNdUK0t3OsbNYEFEnSoMKBmfh6pyB6 Ilk6vcWCLDdqd0raq01DClNhTT6ACltAk4UqTmpRkccIlsUos6agcdbSt5gsOK7zSiFFOHSMIWoU E1W0JTqI4Jg1BBY0G3qN6qpKGuL7dTXtqepktNqUnRPAlQQvPPKQGZjz8vlus6Y2Hfi8bVEztF2L FS19UlqncXRsirTQVDlckhLTzgkgqUkSko4ZYQ/u9Kl7dk7Bfay4WzbG0sUeXdQunu1S5X0rLdje cYufxCtJa+Cj4gUcO6sd3pjJ+pVlKHt3Gv8A8+0Nytgn/oZSmnlqr6dDzFr/ADt5hQc1opl4pB7O CiOEX/8AQrO574J+xtx9klVddvt2u22a6O1LTjN6bNQwlAVNCEnSdUxKYPRHRj8pXtZR8phk8Z0r Vz8xY3bYtBZXG6e4bktbVY4mnWaRS3A8luoI0rKdOXamfRHNT1HVuqzov4OnfZAXtg1NNcb5QVtS zTt2JgVFRVrC/guJdl8MNkCZK59npjVefV1q0vm9hm/CsrWTfy+011NsS4NSU4E+yPRVjz2Y/KhK engmCRSBFA2cCJd7PrgkZP8AKgTMJmJ+yCREfyn/AHeCecEgRNpwPZ6ecEhINdkClTlIz6PRBI5A GxrlgAcBzhD1EE2daFGaMCFc4JCTLln1AjTx9kOSZK1dqlgU44c4ReoF+XaZ9ns4zgBs85aUq4YE +yGRqK561ON8MJCRhF6hZVCCCFJ4HGGEgnLUDiBPH2Q4J1CTlqw7vAc4IHrEnrVgezwVzggNYm7a sT2ePsggesRctf8Au8E84UBrFHLXgcOCucGkNYuu1493j7INIdwWVbMuz83nBpDuAF23A9ngrnBp F3ASrd2suPsg0h3BdVvAGIkJJ5wtIaxN6mEiED52PriWi1Ygi2knWoccB6oFQHlPKoglMyMJJ5wa RaxNyjWsk6TkcJemM3U1V4IG3rJ7vHj1QaB91E/wUgABwEPSR3ADlAFEk+mIdDRZQKqRtJ6cevhC 0oruNgVMjAJHRENGisDcpTI4cDEug65BFdOZ5cfZGLodKuLqp/R0Rm6GquAWxLh0xm6GquQDOJEL SN2IKa9kLSUrEC3E6StRHRC0jkxohQOT2mCAk9phwEnpQAZihEgYYjIMUImDBJJnVhFCg+/hTU9H SO1lUoNUzDZdedOSW0AqUcJ5AR9RZwj5lbTXPLazLqayurae+NXuxqKi2wsKL7TxIIUpLg7JlxGc cKfvN7v3QzsVvshf1uEhDTUitRE8SJAD0mPm/Xf5Bg9LxO1/+r/pqt7/ANL3m/i+JbM9mxcTabXY 7Yw02t9n8Q84JpSo9kJBlM9OIyj8gv8Ayvz/ACXqd9GrdWmxJfj8z5n0mPwMNFun8TbWtsWOraSy 9QJbXpkHWU/DEzjIknHrj6LxfU/L2TktPHev/KZNLeHha+VFDfNirt86ijJdpwZuII7ScP1x9n4f rEtUzbH1eyfy/wAHj+T6c6LVTajVKmg/YKkMZJ5x9A7HkpE7ZXV1LdaF5lp6qcokNVVscDvwmmyy 0lmqaePzCE6tAzwjws9d/v3/AJHvePbd/b8zX7s+Ljabp+XN1VNQVSkllNQsqccrFPB51yfiSkJC UnolGuOrlTv/ACMsl1Djd+ZtlFfdnXdiga3CXE3Le9Km3bg0uBDbTlpSSh5Q4KdOkTjz7UvV7P07 viehS9LLb+rf8Cgsde/ebh5h3h9QbRWWeopqFtagmTbckNITOUzpTkI6b001ovec1L6rXfuJXTbd detjbPfpX6ZKbZbnjWJdqG0upK3NaRonqJIyEXizKl7T7WRlwu9KxGxFn5kWu5XylccZatBsjVDR r/HhbRuRdZQApuYJURMylKMvFaVvbM/A18pN19kR8SsvdTeLnsHaVBUvpWVqeTXqTpLriKQ6aUOk Y4JKpTjq8eiWaxzeRkbw1/r8ATdqDaUplkfdj3VY8Fog7bgGiZeFPOHqCCvNuHzeCucPUEHhQFKu zhj7IeoIJJplACaQcE84WoUDItwUjVpzCj+uDUKDyrckKkZCZwn1Qaggh+WggEDgnnBqCCCrYJHD grnBqFANVsxy4+yHqCBdVrBHd4J5wahQLuWlJB7AyVw9MPUAFdqAMgmQnw6oqRCjlqBEimYknD1w SITdtCJHsDJXD0w5CRZy1AGQTLtdHoipEJOWsEd3gnnDkUiL1rEj2eCucMUiTtrGru+L2QxSV71u QgDVIYJz64Y5K96laAMgT3sh6YA2i5oHFqwaknVmcOHVDE2AXbcMuCecBOoXctuBw4K5wQLUJu0r SFyOergJ8IYSxRdOwQJieCcx6Yke0gq2oKdQQMQo5Y5w4FrYNdCASSMAc/owQLUIqbbAwSck84k0 2gHGxIyRwVzhDRFFMpxRJTJIP65Q4E7QDepNDZVLGSZdc4TQ1aWV66UmeZwVzjNo3VgK6THLj7IW krWB/CYjD5vOJ0l6ybtJ2VYcFQ3UiuTaVrlJjlx9kYup1K4qul9HRGboarILrpvR0xm6GyuANPJW XH2ROkvWQVTno6ITqNXAqp88OmIdTRXBKZx/26IWkpWBlv2RGkvURKPbCgqTBRCgckdMv1QoHJgi CBngIYpMygA8IYEp4QCP0qFsYepHWaloOUzjWh5oiYUhQIUJekYR9Jdny6Rz/wAornsBy919t27T 1VDcqwKKGqxYWlbbRJ0ollIYyVjHnZctcdHZ7kpOt1s4R9A/A/ZPU7CJlt1oaAMcEFM/WY/lz1fz snqPkZcj2t3rC4VhpH2ODEsVFVFrRrbQwgMhLtTTgpeVmEpJJmkcZEyJjTxbVrRKv/VqbH+Hu/Nm xslDVpW2H3lydHZSpRmFEcT1R9b4udWWqz2/5EOO1obb+IVglQ0FIM545/ojuv5Omsz7gNJuVA2m qdSgdgkS/TH3no/mvPg2uXRw/wAv7HzPmYVTJs3M1K6sUluck5c27ep8KIQ4+lnXI9CiJx61qK3s MKXddw9T2UrIcqVqfUcAtR1YaeHoh1qq7ibWdhV7Z9uecDymhq7JnL0xUIWpmKjadI6jRokJK/UY GkJWaKg7MtDlaujQ+2axsBxymCwXEoUMFFE5gHphaEVrYel2NS0ytaeITP8ATDVUhO7ZYU+22Kdw upGMlc4tbDNuSy/ByVgOMv8AwxeoiBeppAGZSz0D9cUrC0mjeYG8LXsCy/mle2p+oeUpmipEEJU6 7niTkkDFRi05BVk5q35u7+apG7/XbLV/pxyTn4lr4oPwz4gsgiUuJSBF7C9COz2pxF2tlJckMO06 Kppt5LFQnQ6gLxkpPAxEmbqXLNICynDgvnEOwoKzc7n5NZq27hg1H4Fpx/4KTIr+G2VaQZHOXRFK w1U03y63mrflDW1n5au2GjdbZ0LWV69Q1TB0pim4HakG6FhwA9o5Kzx4wtREEkNEuALxBVKcvRBI tIQ0IkMOCecGoWkr32VNlSVNjAKx9E4pMWkXWntYt+Lp9EVItIqtAkP2fBPH0w5FpImkQ4gqSOCp j1w5JgUqaBxOLSQZKxBz7sUrEwU7rTpGQBknh6fTFJhBWOp+IpxCHQpaNWtKSJpmeIGUVIQQFK+p Ui3rGrPLwxUkNAnbcCkakzwRhL0w0yBBy1NJBKUAGS+cVIpAO28au74vdipIK6ppg0kdgqMkZDDP pgke8pqlpxwKBwTJfZGHGApJITXRdqQHi92AJMtWiQC3U4yQQn18YaRna5J2jASokSAC+cMzkqap v4iylI/Z6v04QM1qoQgaTAYcE84mCpBKo5zAGernBAahtNAGwEgY6sevTFQYO0lfWU4JSgDIJJ6y YlmtGIrpcDhwVziYNVYEqlxy4+yCA1AU0k1pEvm84SQ3cK9SdhRl4Vw2jOttpVLpccuPsjJ1OpXF V0mGXARGk0VxZykwOHAxLqaq4sulM8Bx9kQ6mqyEVUnZBlmBC0h3BdylPR0xLqaLILrp5HLj7Ih1 NVcWWx7IzdTVXAqZ9sS6misDLePr9kS0WrAyj2RMFyRKfbEwOTGmCByYlBASelAM9KAD9TqWmwT1 I5x7d7HzaRqO76bavlzTP7+p7A3UXcOfDCmv2fbdVIqUQCEzGZCZx5fm4H5GG+JW066us8JUSdWN xZPfBZ+W/m9Z99O17aKNy33cICnqJTgdSaZRktbbgCZqBKc0iU+Mfgvrn8eyejN5Z7mPI9MrY67J eyXt2f8ALn2PcfT+P5azOIhm+sM1FPUtGnXNC8W3093SM59EhmI+SxY748i0PY91vZH9b0dpai50 zygO00hA0oKACkjp0kiRPXHt18/HZ9KXD/XvEMLq6dFO2VuFc1qUlAEpgADEk4Yx2W8qiom3O1iF gV1INSvxqw9R4eiPvP4je18eS73OyPH8/a0fLP8AdcgJ3BtXDNl//GTH6Pg3M8po6P5reYm5tiWa jb21YnK11yjFU/dnUFVHSttpSg6tMpqmoYKIz4xnSqs9rBo5nY91+e1x2bUeZ1De6attVE47+KtD rDQIZpz21AJQmYTnguco1aonpFB2bYu/anzF2I7f7DSsNbhbDtO5RVC1CnRVpkRNSQVaCFBWU+EY 2Wlwwg4H5NL8wb75nXitobmwa9LqVbgeqRr+NTIqAlaGppMspJykI3yQqhB1Pza82Ltt290Ww9kU iK3d1eGtTixrSyXj2EhOAKyO1NRkkYmM6VlS9woNQvW6PPLyqFFf95VNJfLDVuBmqYbDc2lqmSjU 222UqIB0ntJi0q22IIOpb736qxeXbPmBYUJqGHF0VQhp0SDlPUqQFIMsjpVKfAxlVTaBQcme3t56 70YO79n25FLtZLvw6GgCWXXHkoVoKla+0uR7xTpHRlGyVVse8IRtPnD5ebk3vsy2Oshpzc1q1P1F GxMNPKcSA6lorOYImmecKt0mJbDRtj+e723W6bam/wC2OsihSmlVWJQUvIS2nQkPMqAJkBIlP6It 0nagdTuly3TYrbtR7eIqE1Nkap01LbzB1fESTJKU+kqOnHjnGS3wTBx/b9/88vNFupvW06iksNgZ WtFMhwIPxFCRKdS23FKI4qkkRdtNd5UI6Za6rzCpthX2s3vT0tNuC3NVK6R6mKVodSwwVpdUkEpx Iy/UIzlTsFBq3kbvG+bzsl2r9xPturo6htttaG0MhLejUZ6ABGl1ArVNWd8w9/8AmTuKtsvlmGbf Z6An4t0fCVFSNRAWStKgAuXZSEzlxioSW0elIsNo7/3hY97teXvmOlp6rqiPwVzaCU6lLSSiegBK krlpB0gg5wmlEoTqo2BfNzzW3ftR5y2WG0qpqZkModvlUjW2tbqVKSGR3eBxVPEHCCtUwVUa5V7k 839qbdtW/brcKa+7duKG1u0ym0NraD+KQShCCJ5TExPhFKG4HpTOjXPf1motit77CFLo320Lp6Yk BxTzg0hufSFTBPonC9sGWjbBzWz1nnVvik/1HaKmltlsWT+DpVpQA6EKIw1IWoiYlqJE4uUi2qo6 DRXa+2LZ7+4N807dJW0SHVVCaY6kqSFBKOJGpZOABhSZOqb2HPbZfPN/zGS/ettOU1msza1IpkL0 ftFpGKdS0LKj0mQTFTBTrWu8tdibuuO7VXXa1+aTR7st6FIS+2NKVFCi2SUiclIUROWcOSL0S2rc WNg2xW0Ny+M/SKbSS6talESaTpUnQFalFzUSkzwy6YckWco2x2kGrLxe7FpnO0Vr7DTaQVkDBGHH OKTJgqapxICg2meC+0rripDSIqW4FdtAUNXV4YuSXUCVsKACgUmSM8ePohyQ6i7lHTPBRCUrMlzl nnDJ2oXNsZbcKkokdXHHwwyW2AXSCQw4I5w0ySsraCocCkpA+HJchPE48YBppFc7bH0rxbPe4SPh hlakJqoHABNs5I4HphBJligJKnFpwSFy65wyLWDPMBsKWRgFfr0wzNbSjXT6u0cyEk/piTeQK6bA 4cFc4QSCVSkqy8Xuwwkg1RkuIOkykkzlCSFa2wm/SEtrCRMkLAHrimiK22leq2Ok4gDH3YnSa9xC 6rXgNR4JyHpidJXdArtqADMEmSs+uE6lLKwC6IA4Jlj7INI1kFHKTDLgOcRpNVkE3aTA4cDziHU2 WQUcpZHLj7Ih1Na5BNynkMuiM3U3VxRxjPDpiHU3rcXWzj6/ZGbRqrAFN+yIg0Vgake2JaLTIlGc KCpIlMKByY0wQOTGmFASfq7StjSnqRzj07s8JIaqrZQ3Sift9wYRU0VQhxDzLg1JUkniI5bM2SNF rdq7W8rrVer9tWzL/ME06VDW848JJM1CSyZJxmZYx+Peofdef6nT03zckYrWmtlVKdj+Db3Lgz15 phwPNjU2Sjb7Jan4e0o/LjzxO4LorbtzoW6aoruzTupmWllIJLakEnSTLBQPojX13+I19N8a+Xxb WvVfPXJE6fbEf1A/E9QveyrkS2+2u4662mmfcShCHGnFkAJTJYmeicjH5nRY8jSSab+J7Y2RTOOo ZYDlR8IaEJEkJJnMqJxwJjvSpe6pRO8bEt0+/wCJLLFLak4KIJ7PdwSJHIeiP3D0bwX4njqlvme1 xu/BfgeB5GTXefYfKv8AdoANw7T/APJqP8ZEfT+PuZyWOv8AnIkDyYvx/wDgs/8AU1GGP50NrYc7 8qQP/wCatynop7tP7oxrk/8AYhLcN/2lpCtl3z/9FX+A1C8jegqax/bepNN5qbwoKg/DqlIqAlpW CiWqrtD1Ti83yoSKjz521+RebNJui+oqv9J3f8Op2roToeb+E2llxCVykFgJ1gcRFYrTWFvBhbpb f7d00jRd3debil9SQmlaW46sFRwKkraAEszMz6ISeTgLYdH85bHbtt+QblltTrj1tozQopXXjqWp svIUkkyHT0Rnjc3G0bL5BNpX5R7c1AEaH88f+8eicr/6YJFv5ib4sXlzaGbveKWoqGah78OhFIjU RqM1KUSQkADpOOQhUTs4FBxXzg8wfJjeezqh2keVV7nkn8r007jdS05hg4taQNA8Q1H0RvSt0xQT 2jsHct5/tyuFtDazcKxxdfaaNQktTCHELCQD88oWpPTMdMK10rhBLyL81tm7Y2irbO6a02i5291+ aX2l6XEuL1YFIMlAkgpIEPLRtygg6m9vfbW/dg7suG2qhVTS0dNW0zq1oU0daaVSgQFSOkg4GMdL rZSEHK/7ZLYq67M3TRpWEfHqEsauI+Ixpn+uNsrhoUHLNp7f23t/dF22t5m11dYX2DoYqqVa22VL bJHb0pJKVjFCpSjVttShnSto7U8mLzvu30O39wXS53ylP4ymfWVKpyaY69GtaAZ8ej0zjN2sltQi 8/ugpQxsi2qCpk17Y/8ASchYnLElBX7+SB/bXZVdNPbv+tMOvzh7Srq9p1+5f7crOq1NKeraBZrS wgFS3G2lupWEgZkBWqXoitUWF7S48rvN7YtBsm32m+1qbZc7U0mmeacbWfiBtRktBSkzmMxnOC1X JLqbBu12j82PK66ubPcVU/E1FhCkltanKR5LhQUqxBUB2esQlse0lKGcJ2FTeXT9sco94Xm42S80 rqw4ylxbbCkHLSEoVJQOCgY1cmlp9h0nyvs3lsb3XXraVwrquto0hh9VXPQ4HyCVpmkEiaeMG0yv MbTq620rQVJxTJzH1wHPBX1tG8tRLS5dru5eHpi0yYNefplJMlpkqSM+uLTFAi9TiSsOC+cVJMCj lP28vF7sXJLQJu2LeAURpRJGPTjwgklhjQttIKUJlg5M8TjDkyYrVIbZJK89WCRmexFSTBSreezA GkhEky9MMekAt9QB1Ng4Lyw4wydJBT7ZXigjtYyx8MMjQCSWndKUg6iEcPTAJ1gw5T4HqXzhkCzi GgspUoAhWR/4YYQKqbYkO0nJHEdMIIYu4hmR7Scl8R0wwhglhkK7w73uwChi4bQ53TOQRP8ATADU AnKbA4cF84CZArpu1l4vdhhIqqmwGHBPOEORZymwOHBXOENWF3KXtHDxe7BBSsJuUuGI4J5xMGiu JPUsgcOCucS0a1uJPUuJw4+yJaNVcQdpsMuA5xm0dCuIPMYH184zdTorcTcZkThx9kZupvWwotr2 Rm0bqwBSPbENGiZEozhQVIMohQVJgpiYKkxpggcn6u0wwT1I5x2WPHqWLeCT1L5xzWNkHXTsVH7O oQHEFUlJPEacQfQY8T1P0rB59FXKttXKa2NP3M6cWV43sNVovLrbtrvAv1utVMi46i4hwJklCnJg lKD2QZEiYj4r1LwvX8mN4O8s2J8dKb/GVt+o6cFfFpfWq6bfGPgt39jbEMqZQfh07JeWFBxztBKU 5EJGqc/THz2H+L+ctnbom971bEvdDb+Ow9N+ZjXtGadotSSZAAy0oGlOU+s+uPufSP49j8OLXatf 3KKr/f4s8/N5TvsWxBgcB1I5x9WcRS3zaW19yuMv3+0UtyepkuCnXVNJdUgFQJ0lQMsYpWa3AWFw tdtutC7ablStVVsek27SPJC2lICQQCk4SwhJwAnQ7Z27brO7YaC2U1NZahJS/QNNpSwsPYLCkASO oZw5bcgZsu3LBtqmdpNv22ntlM6pbjrVK2lpKl4J1EJAmZACBtveBKg25YbZdK68W+3sU90ubgXX 1baAHXVJRIalf7Y4wNt7BB7jbLbeKJdBdaVqtoXUoDlPUIS42rHilQIgTgDXLX5X+Xljq/zC17co aetTrUh4MhSkmfh1T0+qKd7P2ig2C7Wa036jXbL1Rs19vdWkuU1QgONqKBqSSk4YETiU2twHrXar bZaBm22mlaorewE/BpmEhttGpZUZJGAmSTA3IBqukpq2ndpaxlFRTOpWlxl1IWhQJyKVTBgA1On8 pfLWkrxcKfa9vRVJWFJV8FJSCBOYQZpGPoi9duIoNvSlKUpSkAJAQABgAAYgDVr55bbD3FVm4Xrb 9FV1x1FVQtoBxRBw1KTIq9cWr2W5hBcUe3bFbrcuzUFupqa0uBTTlGy0lDSkLRJQKQADMHGJlgCs e2dv7aYcp9v22ntrDxbcebpW0tJUsYAkJlMyhuze8BbcWzdqbpQkbitNLcS0F/DW+2lS04+FeCh+ mGrNbhGbFtPa21kqa2/a6S2pUrtmnbShSuzxVmfWYbbe8Rm9WPb24aVujv1FT3GlbKHEM1KEupC8 RMAzxkYE2twC9ZYts1loRYKq3071laTpaoFtBTCQ2RokkiQ08IpTvEOW+1W6z0jVutVM3R0DBIZp 2UhDaARMgAYDEwSS0ahe/LjY1xqxcq7blC/VK0KW8WgCpROJWEyCp+mNK2YmP09OxbqVNHbmGqOk bSsNsU6EtISJ8AkCLIZrd62LtK+1hrbvZ6aqrCrtPrQAtUk+IiRPri0xS0MUVot1ppU0lspGqOmS ESaYQG0zn0ACKkh7SSviNalIMsF9WcMkKmobWuTg0K158O7FENAXqZt1ACkhQ0ty/TDTJaKertRk otGYk52T1xckg02tttc3O2vXlwHYipIZBbA0jDwt84aZDRU1ryG0qQ32lycE+AxihaSmebWt0qXi orx/5IoIElMdkYcG+cMQs6zgcOC+cMmAC2O3l4vdhiGqai+E2FKHbUGz1CeUBlYHVgMtKV4iHAke mcBKUlKtklZJxJXifowyxcs4DqRzhAAcZwOHBfOGIEpjtZeL3YYglLTgNlUs9A/QYEZ33knGMDhw XzhmYFbHa+l7sMQqpjAYcEc4AAOMCR6l84AkAtjtZeL3YBSKLpxLLgnnCLkTepsDhwVzhNFKwk9T do4cfZCaNVYrXqfDLgnnGcHRWxW1DEp9SozaOitiveZx9fsiGjprYQcb9kZtHSrC62/bENGqYIox MTBckFIiYKTIaIUFSY0QoHJ+rFP3U9TfON7HmofbyPU5zjCxqhtPe+l7sYstBUd0dSOcQUT4HqXz iRk/F9L3YQzwyHUjnAM8cj1L5whGfF9L3YYzAyHUjnAB45HqXzgEZ8X0vdgAiMh1I5wAeOR6l84A M+L6XuwCMDIdSOcAHjkepfOADPi+l7sAERkOpHOADxyPUvnABLxfS92GITq/3SfoczFITEFZHPJf OLEYPe+l7sAgfAdSOcMCCsj1L5wxFgz3E597xZ92JAC9+5Pd7qO9lnFITKNzJXUvnGpABff+n7sU iWKKyHUjnFIQo7krLJznFECznf8Ap+7FoklST0jvykic5aM/0wEsk93VZd1znDJF3O+cu/7kWZlV Wz+D4paW56JSz48YpCKB3JWWTnOKAXX3+Hf9yKIYmrIZZN84BMVcyVlk5zhiMNS/Eo7n7zxTl3YZ D3Dishlk3zgM2VNy7w/4XJTy73CGOpXr7/Dve7AAue6OpHOEDAOZHLJfOGIEqWvh3vT82GSMMS+A ju5J6fnQ0ZW3kXMjlkvnDIAr73Dve7DELKyGWSOcIGAcyOWS+cMQBfe4d73YCRVcpDLJHT0wihV3 I5ZK5wFIRe7xy73uwi0Vr+XDJPOJNqlXUccvFzjNnVUrXszln7IhnTUr3fkjNnTUVXlw4xDNkBVx iS0QMSUQMIoxCGf/2Q== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/dot.069.gif R0lGODlhAQABAIAAAABmmQAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/auxnav.gif R0lGODlhwQBXAOYAAE2UtjmGrM/l/HuvzRRxnZfA3LXU7mGYtv+ZAGudv4+30VKQtYyyztTm+LjT 6FiRs12avSZul9Tm91SJrcHZ7bfR50WDqsje8Zq+2E2LsM7j9XOgvzl5oVCIrix1nzNxmkR9o2eb u67K4YOuy6/N487i9HalxD2BqDh6oWOUtsDX7KPD25G51NTn+KXG3bnU6YCpx8fd8FyWuFGWt1aZ uUOOsWajwFqcu0mRtD6KrzSDqmCfvi9+pih5oRpplRRhjSFxmw1WhAlOfQAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAADBAFcAAAf/gASCg4SFhoeIiYqLjI2Oj5CRkpODQkJBQZaam5ydnp+goaKjpKWm p6ipqpuZmZauq7Gys7S1tquusLe7vL2+v6Ctl7mausDHyMnKr5evrcTGnNGd08HL19ilusKYzN7N rN/hp8ShsNXS2eK05ejFps/d8sLgzdDv3PX03vL86fn23n07V6+gQYHlhlEjZQxgwHUHIWKaOIzi PIXFGuID16+iuGj39AkMmI/gxnvT9vljlsvhSnop/+krObFmTYU3LcbzaJMlyXhAeeJsubOkvW44 WVpUerFfSJgPmzJ1yhHjzoo2s2rdOi+nVaBNdTrDyo0i1qE8qfYs6rRr2KxH/+Ou9fkWLMmHP7gG yau3b1eyYP3CLSu4sLPChgPrVJyz7dCtR/diystXMuLLfStXrqkZs9bNnkNv7Sx6ImjBlCerloyA c5AJGzAx+IAJhAgRIDBNYJA7CAwGuhkIj7269GfXpFOfNo7a8+bUq5Wj/kGdMl++CFpbZ+Agb4MJ QSJoEF4iQhAGElYEQdFAQl4GMRgoiE1d8nXV0i3nx6/fsmn+9mlW33WkmQZddPndd6B9/YGmIH4F VifhhNlptxcDFewlwQNBpKDBXiWk8IMCElwQxAbtYaJABdBVh+B/L/I3YID9/ddZiw8yuFeLNupX n489zmhdjQAySGCAE1JYYf91DFygAAPfjchiEA4w8AMDFDTwgQsqNLCXAhRM8MAHQg5pnZnK/Sjh jgOiuaaLbZq5o5FzppkmjWUSGCeabMLZJptIJinhktUp4KQCDXCogAN7OaBAECtSYMIFGHg5ogYO VGCCoEn2KaingJ5Z55ujejrhqHbuaSqnoMIZ6plloronp9Rl1+ai1CU6Ync/OLorBg40EIJ7u8JK 65vH9qnsp8Ye6yyrpz4brZ+z5intjj784EO21XGLQJK4/qDrAw1EEIGui4bQAAXkUheutPDGK++8 9NZr77zcZpuvvhMumm2i2VJAAgkUZLvouRg80AJ1LGjwggMYULettt1SbDH/txTnW/GEGHd8ccZJ eiwxx4JqjLG2/I6s8cgkswwyyCezrO/E2+47M78+oJABdQ94kG0EI4zg8w8n7JxBBB48oO0JD8jw wM4Spxz1zCjLvHHVIousssUwc00zzi5LSLPVH5tcc8Ydeyx1yl/X7LbNWLuN9tltU2132XJ3ffPE UaPtNcx0720yymPX7Xfhb8d9c9Vb57343odnS8DbcttdeeCUC044znQTrnjnl2PeNuCiJ/644INX Prfno3POOeuhs0745EBkbnvmpM9tuu6lb2447rfXTbnvtvMePOrDAx888cf7UPvzzk++7eTS11z7 ttdj7/zb2d/e/fHXh2/7//fNk7+9+ds3Xz7l0KvvfubZQ99++u0DUfsBB2yLv/0H7KB//kDYnw/w 5zwBEjCAADwgAQd4gPs1kIH/+x//HmhACibQghGEIAIdyEEGOjCDFYwgAkVoPeehj37x014K5Rc+ 8dXvfOk7nwtj+EL6wRB78kNhDnEIwxa+8HlAjKEJS0hDHrIQhy284fxyuMMgspCJTrSfFKNoPxNW UYZS7OEThyhDKw4RilrkohNteMUq1hCIZhSjCrNYxjF2MYna66EQf/jFI6KRjWbMIxXTyMcpYvGN cGQjINP4RRXW0Yo+9GMb5chHI45xilmM4xYVScknNhKSmMykHjdZSU1mEv+Rn/TkHSkJyj52spSI LGUn7ShKUWLRlZB8JRB6MEsp0lKKCMikDgQgAPsNgJcGGID9alAAARTAAkBIQC+BIIAEAKGYvBTA AqT4S/s105cCMAAyW8nNbnrzm+AMpzi/eUv70TI75qylDXgJACCscwHrhMAzg1kAAwDhl7QUgDAT sE4DJACZtKxmD/QJhAU00wD2FOUty1nLcdrSoVNkaDohudBaSrSVF+VmDza60YaWswcVouUtC1DP BPRAmUCYgQDk2cwerNOdAsinMGUqUvutM5/OhIAAOmCBmlr0pw396UeB+tCKDnWiHLWoT4O61IU2 FagdralPK/pQTD5VqBz/BWlIZ9kDehqgB7/kZQFmqU+w9rKazByASAlqS4ESlAcGKKtQudpUqnK1 qHS1pVTnylCjKnWuRJVqVCnq0b0K9q6IFWlWF6vUrW40AALYAUp/OYNf1mCgJsWnMjcqABvUsqVZ RWtLZ/lLtQ7WqYrN61T/ytis3lWxsM3ra82Z1Nq+dqqpPa1f6Qpbw952scDNzmJ1Gk0c4HOgNhio Wqt53M5ylKCKvSlye2CBzMa0tlEFLnZ/i13tuja7vM3tdwXb3daCd7zeRW9505tVBAB3AMH8pQ0o +0scdNUANkBoDzpgzGLal7Om5SgO+isA+yozAfVkr4IXzOAGr9fBENZu/3ghzAPgVvjCizVAASqs 4bCWtQc4KGYBOrBR+AYzqx+ucIkRGuBfGmAGKnZwjDk648XWeMY1pnGEN5pjHdu4ByrGcHp77F0e GBnIPBaykHnM5BgHGclGxvCFn+xjKFs4q0fGspWpvGUdL7nJYFZylZ/sZC+PGclgRrOUraxlJts4 ylEG8pSPDGc5Q5nOeFZynOls5zXDOctSnnOSB11nP2+50Hc+tJynnOQ193nRf270nucc6EgLOs+Q /jOl+WxpTXM605e+dJ893WlQk7rTnNb0qEV96lYnOs+FJjWk74zoVtva0zq4ta53zete+xrOuSZ1 sH9N7GIL28jD5kGyh/9tAxsYudnPdjYPbJAAZSdgAMqmtpEHkIBcc9vI17Y2tnkQ7mlLewDnlra2 yY1tHTTb2+2GNg+4nWt5h1sH/AT3uOUtb3Q/e9/q3jfAo71tZ+O73VHOdbL/vHBb60DhClf2w4f9 cIkr++LIZjjGK27xi0c84hr3eMZFDvKSA3vjHv84yVPecZBj/OUs3zjFNe7yYHPc5SePuc1JXvKK Q1zmEp/4yh/OgZp3POUml/nMIT7xjzM94TxvObB9vnKJF13oPv+5zYs+dJbbXOVa1zrSsR70ppvd 7BY/O9PBPna0u/3pao872Zve9qzbHdl0n7vayy53p6/d7nFPe97jHoD/iRe+74hPvOIXz/jGO17x h+975HUweblX/vFqr3zhL//wyUd+852nfOhFP3rSi57zoD+86ju/+c+TXvNnT73hmx6A1Z+e8KWn /et1P3vOxz73owc97YWfegSEvvA0EDENCg9ffRY+m7XX5w6iacwADFgAlA+AiQegg+lHswCg/+XD nb+DuL649bdHP/pfX/vs9571u5f97eEvf+Kvv/XCT//xbX//7Nf+/wBYe9nxf5THYggVADRAYMvH SwMAWQMAAM03ANwXVjuAgAoIgXElga33S9HHfcZUfgbgf6nXfgFIgCaIfyhYgiq4gisogifIgvRH ginofgGYfTkQADeI/4O1l4MBUCE6CFngNwBBKAAdCFnQV305wIG1R1LBpH1EGAAGUIFOqIM5qITO V30zUAM8+H9buIM/WII32IVeOIYsWIYq2IViGIY7KIZcGIBs+IVq+IM5cIMVggA66Hw7yIE5cIUZ qE83qIRQKIQGEADFVIK/FIeESIR7OIT4FYeImIOO2IaS+IhjqIZhCIlyCIeZGImY2IZzSIWXmIlU SIZeGIqQmAMVModz6IefeIgOuIjQBH45UEw3CACdVU9JKACqiIO5uItzqIesuAAitoZyaIqlCIqj 6Im8uIyWyIu+eIy++Iyq2IyWeIqa+InYWI3TuI3cmB3b6IeHeIh7OP8A47hOrCiO5shLNyCO56iL 28iOA2BcMzCL7siN9niP+JiP+riP/HiPztiPAHmPCMCNBmgAOXADxhRXOzCO9EiO9DiH9SSExoSQ JCUANwCR9aiKFFlMELCH+IVQARmSIjmSJFmS26iFOYCS06iS03gD5ncDWmhiBbCKM1laKXmINaBh c6iT25eSuciSN5mBc+iS2bSQJ+mTKcmSWgiUR7mUSumTTKmKUYmU9jiVU3mUUsmNKrmUc4iSXOmV UNmVYfmUXfmUWwmUZlmWY5mUahmWbkmVVPmVXxmXYLmVSAmWYumVdgmXUsmVKymWbumXc9mXTpmU NXCYiGmYTnmYign/lYj5mJCpmIkZmZA5l5T5mJJZmY7ZmIbJlpNZmXL5mYWpmYxZmonpmZeZmaWZ mawJmq4pmqopmq/5mrE5m6BZm4tpm7q5m7xJmqOpmo7Zm4+JAzVAnIdpnMNZAxJ4mMupnANQnM0Z nfHonND5nNR5ndLJnNaZndi5nd6pncTJnRIYnt5Jntp5nt2JnuL5ncJZnO6JnK9JnPL5nu+JA/ZZ n8g5n/e5n8fZn8apn/9pn/w5n8UpoAVaoANKoANKn/upnwwqnwpKoO6JnxOqoBV6oRD6oBnqn/7p oAkqoAa6oAAaogmKnyDaoCSKoAF6nwcKoS5aoSKKoC1KoiGqoSd6/6ImOqIymqIl6qEPCqMZeqNC OqREWqRGeqRImqRKuqRM2qRO6qQAYJ9RigNROqUgaqVJOqVWugBSKqBV2qUAYKVfSqUnyqVaaqRY eqJpSqZq2qVkiqVVOqZwCqZsSqRhWqdX2qZfOqd02qcLEKd4+qZryqZyyqVsyqWGGqV/KqALsKhC OqZ4qqhXmqaQmqeMuqdemqmCmqdh6qiYigN/aqaP2qaG+qamKqZumqlxGqasyqpU2qqueqewKquw eqqzuqq3mqu6Wqu72qu4uqe9+qqxuqvC6qu5WqyziqzA6qsIMKu/FKb6ZIvRBK0FwKphhV/Gmq3a uq3c2q3e+q3fOv8DMwAA4jqu5goA2UGu4woAxUSuxmSLJFWt8BqmM1BMEkmu+Hqu9Mqq69qv+1qu 65qvAvuv+Squ6lqw/qqv6mqwDNuvAYuvBQux5lquB3uuBhuxB0uvExuxFquxC0uxACuuFTKxlKVS BWCyAKtPBltM9SoAIYuwIRuzMfuxDTuxFguyMruxOZuzNMuzNYuzHfuyMzu0Oxu0RVuudViu0CRW KsW0KCuu9sqyRzu1VFu1Vnu1WJu1Wlu1NEADM+C1Xvu14uq1Iyu2ImavCRhfX2tMZgtMNiC2cAu3 YSu2XVu0YAu2Y5u3ehu2fFuueHu3dAuweKu3fpu3g1u4gfu3hVv/t3fbtYA7t187uH8LuYz7uGCb HYFLWQlYAJvruCYLtsXEuJErupUbuYlbunTbuJXbt6X7uKMbuImburJbt6Y7u41ruq5LurCrurh7 u46rur8bvAgQvMknAF1rTJtbAOiWvANQvMT7vNAbvdI7vdRbvdZ7vdibvdd7A8HLvdzruN/7u6GL kAOAkNFkA+abTc4bvjTwve7bvvALv+8Lvr/rvfYbv+wbv887v/orv/XbvwBMv977v/07v/nrv/jb vQKcwDfQwAZsvw0svxE8wQhMwRbctRFcwe3rwBAswfebwR+8wSEcwiK8wSbMwR08wQ4swhzsvyn8 whiMvxe8wjTs/74DjMInjMPcCwE5XMMjrMMqDMFCnMI9HMQoHME8DAE63MM53LVK7MFFPMRBDMU8 fAM8XMIQrMQW3MIqzMJcfMRgHMZiPMZkXMZmfMZonMZqvMZszMY7cANvHMdw3MBvLMZ1fMd0PMd5 LMdxLMdwXMcOjMdzDMh6HMiFzMGAnMiGbMh9rMd8jMKPvMeDPMmDLMiEHMh+7Mia3MiT/Mh9vAON DMqeHMp//Ml4/Ml0fMei/MelDMqsPMqr7MqynMqt/MqoPMuinMu6XMq0zMe3XMim7MmV3Mmx7Mix rMvFjMyhvMyVrMy7fMy5PMzOHM3BDM3W3MrT7MvT3My2TM3YnP/N2/zMzszN4FzO5nzO6JzO6rzO 7NzO7uzONgDK8bwD8TzPylzPomzPyDzP+pzL+CzP9BzQAp3PAz3N+tzPAY3P/EzQ/0zQAO3M/2zP Cg3QC/3QCe3PFM3Q9IzQEX3RC13PzdZsG83PEx3SH+3RID3SGy3PCi3SLi3QJS3SFC3TMZ3QHV3R LZ3RH33SKM3SKv3SE+3RMG3T/mzSJr3SL23TIa3ULe3SJE3UKJ3TS93USG3UR13SSL3SPx3TTc3V Tl3VXz3VT33VM+3UKW3VaJ3War3WbN3Wbv3WcB3Xcj3XdF3XbY1ua43XRo1ueq3WfW3XgB3YIf3X eV3Ydk3YzcYE120dCAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-BOTTOM: 0px; BACKGROUND-COLOR: #fff; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; COLOR: #333; PADDING-TOP: 0px } H1 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H2 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H3 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H4 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H5 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H6 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } LI { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } DT { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } DD { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } .txt { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } FIELDSET { BORDER-BOTTOM-STYLE: none !important; PADDING-BOTTOM: 0px !important; = BORDER-RIGHT-STYLE: none !important; MARGIN: 0px; PADDING-LEFT: 0px = !important; PADDING-RIGHT: 0px !important; BORDER-TOP-STYLE: none = !important; BORDER-LEFT-STYLE: none !important; PADDING-TOP: 0px = !important } LEGEND { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-BOTTOM: 0px; MARGIN: 0.25em 0px 0.25em 1.25em; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } DL { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DT { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DD { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment LI { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment LI { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment TD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment DD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment DD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment H1 { COLOR: #f90; FONT-SIZE: 20px; FONT-WEIGHT: bold } .homepageFragment H2 { COLOR: #f90; FONT-SIZE: 18px; FONT-WEIGHT: bold } .homepageFragment H3 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H4 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H5 { COLOR: #f90; FONT-SIZE: 14px; FONT-WEIGHT: bold } .homepageFragment H6 { COLOR: #f90; FONT-SIZE: 12px; FONT-WEIGHT: bold } .HomepageFragment H1 { COLOR: #f90; FONT-SIZE: 20px; FONT-WEIGHT: bold } .HomepageFragment H2 { COLOR: #f90; FONT-SIZE: 18px; FONT-WEIGHT: bold } .HomepageFragment H3 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .HomepageFragment H4 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .HomepageFragment H5 { COLOR: #f90; FONT-SIZE: 14px; FONT-WEIGHT: bold } .HomepageFragment H6 { COLOR: #f90; FONT-SIZE: 12px; FONT-WEIGHT: bold } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, sans-serif; = FONT-SIZE: 11px } .HomepageFragment ADDRESS { FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, sans-serif; = FONT-SIZE: 11px } TABLE.menuIEFOUR { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; BACKGROUND-COLOR: #13709d; MARGIN: 0px; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: left top } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .menuIEFOURSIDE { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .menuIEFOURDOWN { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } TABLE.menuIEFOUR TD { PADDING-BOTTOM: 0.2em; FONT-SIZE: 70%; FONT-WEIGHT: bold; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; COLOR: white; FONT-WEIGHT: normal; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { TEXT-TRANSFORM: uppercase; FONT-STYLE: normal; COLOR: #6089b2; = FONT-SIZE: 0.7em; FONT-WEIGHT: bold } H3.navigationHeader EM { FONT-STYLE: normal; COLOR: #ff9b06; FONT-SIZE: 1.1em } .homepageFragment .mostAccessed { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-BOTTOM: 0px; MARGIN: 0.25em; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif; COLOR: #ff9900; = FONT-SIZE: 11px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .HomepageFragment .mostAccessed LI { PADDING-BOTTOM: 0px; MARGIN: 0.25em; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif; COLOR: #ff9900; = FONT-SIZE: 11px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI DIV { COLOR: #000000; FONT-SIZE: 100%; FONT-WEIGHT: normal } .HomepageFragment .mostAccessed LI DIV { COLOR: #000000; FONT-SIZE: 100%; FONT-WEIGHT: normal } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } DIV.banner TABLE TD A { DISPLAY: block } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-COLOR: #13709d; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-POSITION: left top } UL.menuDOM LI { BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0.2em; DISPLAY: block; FLOAT: = left; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { PADDING-BOTTOM: 0px; DISPLAY: block; BACKGROUND: white; COLOR: white; = FONT-SIZE: 100%; FONT-WEIGHT: bold; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuDOM LI UL { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuIEMAC { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuDOM A { PADDING-BOTTOM: 0.1em; PADDING-LEFT: 0.1em; PADDING-RIGHT: 0.1em; = DISPLAY: block; COLOR: #90d7ff; FONT-WEIGHT: bold; PADDING-TOP: 0.1em } .hideNSFOUR LI A { WHITE-SPACE: normal } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } LI.nosaved EM { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1em; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: left center } UL.menuIEMAC A.menuSideArrow { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1em; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: left center } UL.menuDOM LI UL { POSITION: absolute; TOP: 2.25em; LEFT: -999em } UL.menuDOM LI.menuhover UL { Z-INDEX: 999; BORDER-BOTTOM: #90d7ff 1px solid; BORDER-LEFT: #90d7ff = 1px solid; WIDTH: 200px; DISPLAY: block; BACKGROUND: white; MARGIN-LEFT: = -1.25em; BORDER-TOP: #90d7ff 1px solid; TOP: auto; BORDER-RIGHT: #90d7ff = 1px solid; LEFT: auto; voice-family: inherit } UL.menuDOM LI IFRAME { POSITION: absolute; TOP: 2.25em; LEFT: -999em } UL.menuDOM LI.menuhover IFRAME { Z-INDEX: 998; WIDTH: 202px; MARGIN-LEFT: -1.25em; TOP: auto; LEFT: auto } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-BOTTOM: 5px; MARGIN-TOP: 0px !important; PADDING-LEFT: 5px; = WIDTH: 190px; PADDING-RIGHT: 5px; DISPLAY: block; BACKGROUND: #ff9900; = COLOR: white !important; FONT-WEIGHT: bold; PADDING-TOP: 5px; = voice-family: inherit } LI.nosaved EM { COLOR: black !important; FONT-WEIGHT: normal !important; = TEXT-DECORATION: none !important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none !important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif) = !important; MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1.25em; = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .domArrowOut { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) = !important; MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1.25em; = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } UL.menuIEMAC A { PADDING-BOTTOM: 0.1em; PADDING-LEFT: 0.1em; PADDING-RIGHT: 0.1em; = COLOR: #90d7ff; FONT-WEIGHT: bold; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { PADDING-BOTTOM: 3px; DISPLAY: inline } UL.menuIEMAC LI UL { POSITION: absolute; LEFT: -999em } UL.menuIEMAC { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif) = !important; PADDING-BOTTOM: 0.1em; BACKGROUND-COLOR: #13709d; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: left top } #user { BACKGROUND-IMAGE: none; PADDING-LEFT: 5em; PADDING-RIGHT: 2em; COLOR: = white } #mycart { BACKGROUND-IMAGE: none; PADDING-LEFT: 5em; COLOR: white } #menu { BORDER-BOTTOM: transparent 1px solid; BORDER-LEFT: transparent 1px = solid; BORDER-TOP: transparent 1px solid; BORDER-RIGHT: transparent 1px = solid } .hideNSFOUR LI A { WHITE-SPACE: normal } .hideNSFOUR LI { WHITE-SPACE: normal } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.standards.css @import url( /freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { MARGIN: 0.25em 0em; PADDING-LEFT: 1em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: url(/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-IMAGE: url(/images/bg.basic.gif); BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 100% 100% } #searchBox { BACKGROUND-IMAGE: url(/images/bg.search.gif); BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 0% 100% } #citationBox { BACKGROUND-IMAGE: url(/images/bg.citation-finder.gif); = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: 0% 0% } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-BOTTOM: 2px; TEXT-INDENT: -16px; MARGIN: 0px; PADDING-LEFT: = 22px; PADDING-RIGHT: 3px; COLOR: #666; FONT-WEIGHT: bold; PADDING-TOP: = 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-BOTTOM: 2px; TEXT-INDENT: -16px; MARGIN: 0px; PADDING-LEFT: = 22px; PADDING-RIGHT: 3px; COLOR: #666; FONT-WEIGHT: bold; PADDING-TOP: = 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .dataTable TH { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { TEXT-ALIGN: right; MARGIN: 0px; FONT-WEIGHT: bold } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { BORDER-BOTTOM: #ccc 2px solid; COLOR: #f90 } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { TEXT-ALIGN: left; FONT-WEIGHT: normal } #contentFrame .mainCol #footer { MARGIN: 10px 10px 0px; BORDER-TOP: #ccc 2px solid; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { MARGIN-BOTTOM: 0px; COLOR: #666; FONT-SIZE: 70% } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { BORDER-LEFT: #ccc 1px solid; PADDING-BOTTOM: 7px; MARGIN: 0px 0px 15px; = PADDING-LEFT: 10px; PADDING-RIGHT: 10px; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = MARGIN-BOTTOM: 0px; BORDER-LEFT-STYLE: none; PADDING-TOP: 10px } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { BORDER-BOTTOM: #cce5ff 1px solid; MARGIN-TOP: 1px } #contentFrame .sideCol #citationBox .item { PADDING-BOTTOM: 10px; MARGIN: 0px 10px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { MARGIN-BOTTOM: 0px; COLOR: #666; FONT-SIZE: 70% } #contentFrame .sideCol #relatedProducts UL { PADDING-BOTTOM: 8px; MARGIN-TOP: 0px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { TEXT-ALIGN: right; PADDING-RIGHT: 0.5em } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { COLOR: #9cf; FONT-WEIGHT: bold; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-IMAGE: url(/images/fill.personal-nav.gif); WIDTH: 100%; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: right top } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = WHITE-SPACE: nowrap; PADDING-TOP: 0px } #personalnavSpecial { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-WEIGHT: bold; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-BOTTOM: #069 2px solid; BORDER-LEFT: #069 2px solid; = PADDING-BOTTOM: 2px; PADDING-LEFT: 2px; PADDING-RIGHT: 2px; FONT-FAMILY: = arial; FONT-SIZE: 11pt; BORDER-TOP: #069 2px solid; BORDER-RIGHT: #069 = 2px solid; PADDING-TOP: 2px } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { TEXT-ALIGN: center; LINE-HEIGHT: 140% } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: url(/images/bg.logo.home.jpg); BACKGROUND-COLOR: = #001941; BACKGROUND-REPEAT: no-repeat } #logoCell { BACKGROUND-IMAGE: url(/images/bg.logo.jpg); BACKGROUND-REPEAT: = no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; COLOR: #666; FONT-WEIGHT: bold } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-BOTTOM: red 1px solid; BORDER-LEFT: red 1px solid; = BACKGROUND-COLOR: #fcc; BORDER-TOP: red 1px solid; BORDER-RIGHT: red 1px = solid } #browserWarning { BORDER-BOTTOM: #c00 1px solid; BORDER-LEFT: #c00 1px solid; = PADDING-BOTTOM: 0.3em; BACKGROUND-COLOR: #fef; MARGIN: 5px 28px; = PADDING-LEFT: 0.3em; PADDING-RIGHT: 0.3em; FONT-FAMILY: arial; COLOR: = #300; FONT-SIZE: 100%; BORDER-TOP: #c00 1px solid; BORDER-RIGHT: #c00 = 1px solid; PADDING-TOP: 0.3em } .invisible { POSITION: absolute; WIDTH: 0px; HEIGHT: 0px; OVERFLOW: hidden } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { MARGIN: 10px; FLOAT: left } .linkPrint { MARGIN: 10px 20px 0px 0px; FLOAT: right } .linkTop { TEXT-ALIGN: right; CLEAR: both } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { COLOR: #c00; FONT-WEIGHT: bold } #errorList LI { LIST-STYLE-TYPE: none; COLOR: #c00 !important; FONT-WEIGHT: bold } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 0px !important } #contentFrame #intro .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { BORDER-LEFT: #ccc 1px solid; PADDING-BOTTOM: 6px; MARGIN: 10px 0px; = PADDING-LEFT: 8px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { COLOR: #369; FONT-SIZE: 80% } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { TEXT-INDENT: -2em; MARGIN: 0px; PADDING-LEFT: 2em; COLOR: #666 } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { LINE-HEIGHT: 150%; MARGIN-TOP: 8px; COLOR: #000; BORDER-TOP: #ccc 1px = solid; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalReferences .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalArticleMain .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { TEXT-ALIGN: center; MARGIN: 0px } #contentFrame #content .issueNav SPAN { COLOR: #f90; FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { BORDER-BOTTOM: #ccc 1px solid; PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px = 0.5em; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px = solid; PADDING-TOP: 0.5em } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-BOTTOM: 10px; PADDING-LEFT: 6px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none !important } .journalArticleMain #intro .item { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 0px !important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px !important; PADDING-TOP: 10px !important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px !important } .journalArticleMain #searchBox { WIDTH: 150px; BORDER-RIGHT: #99c2d6 1px solid } .journalArticleMain #intro #searchBox .item { PADDING-BOTTOM: 10px !important; PADDING-LEFT: 10px !important; = PADDING-RIGHT: 10px !important; PADDING-TOP: 10px !important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px !important; PADDING-TOP: 0px !important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = BACKGROUND: #565565; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { COLOR: #369; FONT-SIZE: 80% } #contentFrame #content .prerendered { FONT-FAMILY: arial, helvetica, sans-serif; COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered TABLE { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { BACKGROUND-COLOR: #fff; COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered TH { BACKGROUND-COLOR: #fff; COLOR: #333; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { COLOR: #333; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT A { COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered FONT[size=3D'+1'] { COLOR: #666; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-SIZE: 14px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT[size=3D'4'] A { COLOR: #090; FONT-SIZE: 14px } #contentFrame #content .prerendered P { COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-FAMILY: arial, helvetica, sans-serif; COLOR: #333; FONT-SIZE: 12px } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-SIZE: 140%; FONT-WEIGHT: bold } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { TEXT-TRANSFORM: uppercase; DISPLAY: block; COLOR: #f90; FONT-SIZE: = 110%; FONT-WEIGHT: bold } .prerendered .firstLevelHeading { DISPLAY: block; COLOR: #369; FONT-SIZE: 11pt; FONT-WEIGHT: bold } .prerendered .secondLevelHeading { DISPLAY: block; COLOR: #369; FONT-SIZE: 11pt } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { COLOR: #369; FONT-SIZE: 10pt } .prerendered .referenceNum { COLOR: #369; FONT-SIZE: 10pt } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/jquery.js /*=0A= * jQuery 1.2.6 - New Wave Javascript=0A= *=0A= * Copyright (c) 2008 John Resig (jquery.com)=0A= * Dual licensed under the MIT (MIT-LICENSE.txt)=0A= * and GPL (GPL-LICENSE.txt) licenses.=0A= *=0A= * $Date: 2008-07-02 17:45:25 +0100 (Wed, 02 Jul 2008) $=0A= * $Rev: 20679 $=0A= */=0A= (function(){var _jQuery=3Dwindow.jQuery,_$=3Dwindow.$;var = jQuery=3Dwindow.jQuery=3Dwindow.$=3Dfunction(selector,context){return = new jQuery.fn.init(selector,context);};var = quickExpr=3D/^[^<]*(<(.|\s)+>)[^>]*$|^#(\w+)$/,isSimple=3D/^.[^:#\[\.]*$/= ,undefined;jQuery.fn=3DjQuery.prototype=3D{init:function(selector,context= ){selector=3Dselector||document;if(selector.nodeType){this[0]=3Dselector;= this.length=3D1;return this;}if(typeof selector=3D=3D"string"){var = match=3DquickExpr.exec(selector);if(match&&(match[1]||!context)){if(match= [1])selector=3DjQuery.clean([match[1]],context);else{var = elem=3Ddocument.getElementById(match[3]);if(elem){if(elem.id!=3Dmatch[3])= return jQuery().find(selector);return jQuery(elem);}selector=3D[];}}else=0A= return jQuery(context).find(selector);}else = if(jQuery.isFunction(selector))return = jQuery(document)[jQuery.fn.ready?"ready":"load"](selector);return = this.setArray(jQuery.makeArray(selector));},jquery:"1.2.6",size:function(= ){return this.length;},length:0,get:function(num){return = num=3D=3Dundefined?jQuery.makeArray(this):this[num];},pushStack:function(= elems){var ret=3DjQuery(elems);ret.prevObject=3Dthis;return = ret;},setArray:function(elems){this.length=3D0;Array.prototype.push.apply= (this,elems);return this;},each:function(callback,args){return = jQuery.each(this,callback,args);},index:function(elem){var = ret=3D-1;return = jQuery.inArray(elem&&elem.jquery?elem[0]:elem,this);},attr:function(name,= value,type){var = options=3Dname;if(name.constructor=3D=3DString)if(value=3D=3D=3Dundefined= )return = this[0]&&jQuery[type||"attr"](this[0],name);else{options=3D{};options[nam= e]=3Dvalue;}return this.each(function(i){for(name in = options)jQuery.attr(type?this.style:this,name,jQuery.prop(this,options[na= me],type,i,name));});},css:function(key,value){if((key=3D=3D'width'||key=3D= =3D'height')&&parseFloat(value)<0)value=3Dundefined;return = this.attr(key,value,"curCSS");},text:function(text){if(typeof = text!=3D"object"&&text!=3Dnull)return = this.empty().append((this[0]&&this[0].ownerDocument||document).createText= Node(text));var = ret=3D"";jQuery.each(text||this,function(){jQuery.each(this.childNodes,fu= nction(){if(this.nodeType!=3D8)ret+=3Dthis.nodeType!=3D1?this.nodeValue:j= Query.fn.text([this]);});});return = ret;},wrapAll:function(html){if(this[0])jQuery(html,this[0].ownerDocument= ).clone().insertBefore(this[0]).map(function(){var = elem=3Dthis;while(elem.firstChild)elem=3Delem.firstChild;return = elem;}).append(this);return this;},wrapInner:function(html){return = this.each(function(){jQuery(this).contents().wrapAll(html);});},wrap:func= tion(html){return = this.each(function(){jQuery(this).wrapAll(html);});},append:function(){re= turn = this.domManip(arguments,true,false,function(elem){if(this.nodeType=3D=3D1= )this.appendChild(elem);});},prepend:function(){return = this.domManip(arguments,true,true,function(elem){if(this.nodeType=3D=3D1)= this.insertBefore(elem,this.firstChild);});},before:function(){return = this.domManip(arguments,false,false,function(elem){this.parentNode.insert= Before(elem,this);});},after:function(){return = this.domManip(arguments,false,true,function(elem){this.parentNode.insertB= efore(elem,this.nextSibling);});},end:function(){return = this.prevObject||jQuery([]);},find:function(selector){var = elems=3DjQuery.map(this,function(elem){return = jQuery.find(selector,elem);});return this.pushStack(/[^+>] = [^+>]/.test(selector)||selector.indexOf("..")>-1?jQuery.unique(elems):ele= ms);},clone:function(events){var = ret=3Dthis.map(function(){if(jQuery.browser.msie&&!jQuery.isXMLDoc(this))= {var = clone=3Dthis.cloneNode(true),container=3Ddocument.createElement("div");co= ntainer.appendChild(clone);return = jQuery.clean([container.innerHTML])[0];}else=0A= return this.cloneNode(true);});var = clone=3Dret.find("*").andSelf().each(function(){if(this[expando]!=3Dundef= ined)this[expando]=3Dnull;});if(events=3D=3D=3Dtrue)this.find("*").andSel= f().each(function(i){if(this.nodeType=3D=3D3)return;var = events=3DjQuery.data(this,"events");for(var type in events)for(var = handler in = events[type])jQuery.event.add(clone[i],type,events[type][handler],events[= type][handler].data);});return ret;},filter:function(selector){return = this.pushStack(jQuery.isFunction(selector)&&jQuery.grep(this,function(ele= m,i){return = selector.call(elem,i);})||jQuery.multiFilter(selector,this));},not:functi= on(selector){if(selector.constructor=3D=3DString)if(isSimple.test(selecto= r))return this.pushStack(jQuery.multiFilter(selector,this,true));else=0A= selector=3DjQuery.multiFilter(selector,this);var = isArrayLike=3Dselector.length&&selector[selector.length-1]!=3D=3Dundefine= d&&!selector.nodeType;return this.filter(function(){return = isArrayLike?jQuery.inArray(this,selector)<0:this!=3Dselector;});},add:fun= ction(selector){return = this.pushStack(jQuery.unique(jQuery.merge(this.get(),typeof = selector=3D=3D'string'?jQuery(selector):jQuery.makeArray(selector))));},i= s:function(selector){return!!selector&&jQuery.multiFilter(selector,this).= length>0;},hasClass:function(selector){return = this.is("."+selector);},val:function(value){if(value=3D=3Dundefined){if(t= his.length){var elem=3Dthis[0];if(jQuery.nodeName(elem,"select")){var = index=3Delem.selectedIndex,values=3D[],options=3Delem.options,one=3Delem.= type=3D=3D"select-one";if(index<0)return null;for(var = i=3Done?index:0,max=3Done?index+1:options.length;i=3D0||jQuery.inArray(this.name,value)>=3D0);else = if(jQuery.nodeName(this,"select")){var = values=3DjQuery.makeArray(value);jQuery("option",this).each(function(){th= is.selected=3D(jQuery.inArray(this.value,values)>=3D0||jQuery.inArray(thi= s.text,values)>=3D0);});if(!values.length)this.selectedIndex=3D-1;}else=0A= this.value=3Dvalue;});},html:function(value){return = value=3D=3Dundefined?(this[0]?this[0].innerHTML:null):this.empty().append= (value);},replaceWith:function(value){return = this.after(value).remove();},eq:function(i){return = this.slice(i,i+1);},slice:function(){return = this.pushStack(Array.prototype.slice.apply(this,arguments));},map:functio= n(callback){return = this.pushStack(jQuery.map(this,function(elem,i){return = callback.call(elem,i,elem);}));},andSelf:function(){return = this.add(this.prevObject);},data:function(key,value){var = parts=3Dkey.split(".");parts[1]=3Dparts[1]?"."+parts[1]:"";if(value=3D=3D= =3Dundefined){var = data=3Dthis.triggerHandler("getData"+parts[1]+"!",[parts[0]]);if(data=3D=3D= =3Dundefined&&this.length)data=3DjQuery.data(this[0],key);return = data=3D=3D=3Dundefined&&parts[1]?this.data(parts[0]):data;}else=0A= return = this.trigger("setData"+parts[1]+"!",[parts[0],value]).each(function(){jQu= ery.data(this,key,value);});},removeData:function(key){return = this.each(function(){jQuery.removeData(this,key);});},domManip:function(a= rgs,table,reverse,callback){var clone=3Dthis.length>1,elems;return = this.each(function(){if(!elems){elems=3DjQuery.clean(args,this.ownerDocum= ent);if(reverse)elems.reverse();}var = obj=3Dthis;if(table&&jQuery.nodeName(this,"table")&&jQuery.nodeName(elems= [0],"tr"))obj=3Dthis.getElementsByTagName("tbody")[0]||this.appendChild(t= his.ownerDocument.createElement("tbody"));var = scripts=3DjQuery([]);jQuery.each(elems,function(){var = elem=3Dclone?jQuery(this).clone(true)[0]:this;if(jQuery.nodeName(elem,"sc= ript"))scripts=3Dscripts.add(elem);else{if(elem.nodeType=3D=3D1)scripts=3D= scripts.add(jQuery("script",elem).remove());callback.call(obj,elem);}});s= cripts.each(evalScript);});}};jQuery.fn.init.prototype=3DjQuery.fn;functi= on = evalScript(i,elem){if(elem.src)jQuery.ajax({url:elem.src,async:false,data= Type:"script"});else=0A= jQuery.globalEval(elem.text||elem.textContent||elem.innerHTML||"");if(ele= m.parentNode)elem.parentNode.removeChild(elem);}function = now(){return+new Date;}jQuery.extend=3DjQuery.fn.extend=3Dfunction(){var = target=3Darguments[0]||{},i=3D1,length=3Darguments.length,deep=3Dfalse,op= tions;if(target.constructor=3D=3DBoolean){deep=3Dtarget;target=3Dargument= s[1]||{};i=3D2;}if(typeof target!=3D"object"&&typeof = target!=3D"function")target=3D{};if(length=3D=3Di){target=3Dthis;--i;}for= (;i= -1;}},swap:function(elem,options,callback){var old=3D{};for(var name in = options){old[name]=3Delem.style[name];elem.style[name]=3Doptions[name];}c= allback.call(elem);for(var name in = options)elem.style[name]=3Dold[name];},css:function(elem,name,force){if(n= ame=3D=3D"width"||name=3D=3D"height"){var = val,props=3D{position:"absolute",visibility:"hidden",display:"block"},whi= ch=3Dname=3D=3D"width"?["Left","Right"]:["Top","Bottom"];function = getWH(){val=3Dname=3D=3D"width"?elem.offsetWidth:elem.offsetHeight;var = padding=3D0,border=3D0;jQuery.each(which,function(){padding+=3DparseFloat= (jQuery.curCSS(elem,"padding"+this,true))||0;border+=3DparseFloat(jQuery.= curCSS(elem,"border"+this+"Width",true))||0;});val-=3DMath.round(padding+= border);}if(jQuery(elem).is(":visible"))getWH();else=0A= jQuery.swap(elem,props,getWH);return Math.max(0,val);}return = jQuery.curCSS(elem,name,force);},curCSS:function(elem,name,force){var = ret,style=3Delem.style;function = color(elem){if(!jQuery.browser.safari)return false;var = ret=3DdefaultView.getComputedStyle(elem,null);return!ret||ret.getProperty= Value("color")=3D=3D"";}if(name=3D=3D"opacity"&&jQuery.browser.msie){ret=3D= jQuery.attr(style,"opacity");return = ret=3D=3D""?"1":ret;}if(jQuery.browser.opera&&name=3D=3D"display"){var = save=3Dstyle.outline;style.outline=3D"0 solid = black";style.outline=3Dsave;}if(name.match(/float/i))name=3DstyleFloat;if= (!force&&style&&style[name])ret=3Dstyle[name];else = if(defaultView.getComputedStyle){if(name.match(/float/i))name=3D"float";n= ame=3Dname.replace(/([A-Z])/g,"-$1").toLowerCase();var = computedStyle=3DdefaultView.getComputedStyle(elem,null);if(computedStyle&= &!color(elem))ret=3DcomputedStyle.getPropertyValue(name);else{var = swap=3D[],stack=3D[],a=3Delem,i=3D0;for(;a&&color(a);a=3Da.parentNode)sta= ck.unshift(a);for(;i]*?)\/>/g,function(all= ,front,tag){return = tag.match(/^(abbr|br|col|img|input|link|meta|param|hr|area|embed)$/i)?all= :front+">";});var = tags=3DjQuery.trim(elem).toLowerCase(),div=3Dcontext.createElement("div")= ;var wrap=3D!tags.indexOf("",""]||!tags.indexOf("",""]||tags.match(/^<(thead|tbody|tfoot|colg|cap)/)&&[1,"",""]||!tags.indexOf("",""]||(!tags.indexOf("= ",""]||!tags.indexOf("= ",""]||jQuery.browser.msie&&[1,"div<= div>",""]||[0,"",""];div.innerHTML=3Dwrap[1]+elem+wrap[2];while(wra= p[0]--)div=3Ddiv.lastChild;if(jQuery.browser.msie){var = tbody=3D!tags.indexOf(""&&tags.indexOf("=3D0;--j)if(jQuery.nodeName(tbody[j],"tbody")&&!tbod= y[j].childNodes.length)tbody[j].parentNode.removeChild(tbody[j]);if(/^\s/= .test(elem))div.insertBefore(context.createTextNode(elem.match(/^\s*/)[0]= ),div.firstChild);}elem=3DjQuery.makeArray(div.childNodes);}if(elem.lengt= h=3D=3D=3D0&&(!jQuery.nodeName(elem,"form")&&!jQuery.nodeName(elem,"selec= t")))return;if(elem[0]=3D=3Dundefined||jQuery.nodeName(elem,"form")||elem= .options)ret.push(elem);else=0A= ret=3DjQuery.merge(ret,elem);});return = ret;},attr:function(elem,name,value){if(!elem||elem.nodeType=3D=3D3||elem= .nodeType=3D=3D8)return undefined;var = notxml=3D!jQuery.isXMLDoc(elem),set=3Dvalue!=3D=3Dundefined,msie=3DjQuery= .browser.msie;name=3Dnotxml&&jQuery.props[name]||name;if(elem.tagName){va= r = special=3D/href|src|style/.test(name);if(name=3D=3D"selected"&&jQuery.bro= wser.safari)elem.parentNode.selectedIndex;if(name in = elem&¬xml&&!special){if(set){if(name=3D=3D"type"&&jQuery.nodeName(elem= ,"input")&&elem.parentNode)throw"type property can't be = changed";elem[name]=3Dvalue;}if(jQuery.nodeName(elem,"form")&&elem.getAtt= ributeNode(name))return elem.getAttributeNode(name).nodeValue;return = elem[name];}if(msie&¬xml&&name=3D=3D"style")return = jQuery.attr(elem.style,"cssText",value);if(set)elem.setAttribute(name,""+= value);var = attr=3Dmsie&¬xml&&special?elem.getAttribute(name,2):elem.getAttribute(= name);return = attr=3D=3D=3Dnull?undefined:attr;}if(msie&&name=3D=3D"opacity"){if(set){e= lem.zoom=3D1;elem.filter=3D(elem.filter||"").replace(/alpha\([^)]*\)/,"")= +(parseInt(value)+''=3D=3D"NaN"?"":"alpha(opacity=3D"+value*100+")");}ret= urn = elem.filter&&elem.filter.indexOf("opacity=3D")>=3D0?(parseFloat(elem.filt= er.match(/opacity=3D([^)]*)/)[1])/100)+'':"";}name=3Dname.replace(/-([a-z= ])/ig,function(all,letter){return = letter.toUpperCase();});if(set)elem[name]=3Dvalue;return = elem[name];},trim:function(text){return(text||"").replace(/^\s+|\s+$/g,""= );},makeArray:function(array){var ret=3D[];if(array!=3Dnull){var = i=3Darray.length;if(i=3D=3Dnull||array.split||array.setInterval||array.ca= ll)ret[0]=3Darray;else=0A= while(i)ret[--i]=3Darray[i];}return = ret;},inArray:function(elem,array){for(var = i=3D0,length=3Darray.length;i*",t= his).remove();while(this.firstChild)this.removeChild(this.firstChild);}},= function(name,fn){jQuery.fn[name]=3Dfunction(){return = this.each(fn,arguments);};});jQuery.each(["Height","Width"],function(i,na= me){var = type=3Dname.toLowerCase();jQuery.fn[type]=3Dfunction(size){return = this[0]=3D=3Dwindow?jQuery.browser.opera&&document.body["client"+name]||j= Query.browser.safari&&window["inner"+name]||document.compatMode=3D=3D"CSS= 1Compat"&&document.documentElement["client"+name]||document.body["client"= +name]:this[0]=3D=3Ddocument?Math.max(Math.max(document.body["scroll"+nam= e],document.documentElement["scroll"+name]),Math.max(document.body["offse= t"+name],document.documentElement["offset"+name])):size=3D=3Dundefined?(t= his.length?jQuery.css(this[0],type):null):this.css(type,size.constructor=3D= =3DString?size:size+"px");};});function num(elem,prop){return = elem[0]&&parseInt(jQuery.curCSS(elem[0],prop,true),10)||0;}var = chars=3DjQuery.browser.safari&&parseInt(jQuery.browser.version)<417?"(?:[= \\w*_-]|\\\\.)":"(?:[\\w\u0128-\uFFFF*_-]|\\\\.)",quickChild=3Dnew = RegExp("^>\\s*("+chars+"+)"),quickID=3Dnew = RegExp("^("+chars+"+)(#)("+chars+"+)"),quickClass=3Dnew = RegExp("^([#.]?)("+chars+"*)");jQuery.extend({expr:{"":function(a,i,m){re= turn m[2]=3D=3D"*"||jQuery.nodeName(a,m[2]);},"#":function(a,i,m){return = a.getAttribute("id")=3D=3Dm[2];},":":{lt:function(a,i,m){return = im[3]-0;},nth:function(a,i,m){return = m[3]-0=3D=3Di;},eq:function(a,i,m){return = m[3]-0=3D=3Di;},first:function(a,i){return = i=3D=3D0;},last:function(a,i,m,r){return = i=3D=3Dr.length-1;},even:function(a,i){return = i%2=3D=3D0;},odd:function(a,i){return = i%2;},"first-child":function(a){return = a.parentNode.getElementsByTagName("*")[0]=3D=3Da;},"last-child":function(= a){return = jQuery.nth(a.parentNode.lastChild,1,"previousSibling")=3D=3Da;},"only-chi= ld":function(a){return!jQuery.nth(a.parentNode.lastChild,2,"previousSibli= ng");},parent:function(a){return = a.firstChild;},empty:function(a){return!a.firstChild;},contains:function(= a,i,m){return(a.textContent||a.innerText||jQuery(a).text()||"").indexOf(m= [3])>=3D0;},visible:function(a){return"hidden"!=3Da.type&&jQuery.css(a,"d= isplay")!=3D"none"&&jQuery.css(a,"visibility")!=3D"hidden";},hidden:funct= ion(a){return"hidden"=3D=3Da.type||jQuery.css(a,"display")=3D=3D"none"||j= Query.css(a,"visibility")=3D=3D"hidden";},enabled:function(a){return!a.di= sabled;},disabled:function(a){return = a.disabled;},checked:function(a){return = a.checked;},selected:function(a){return = a.selected||jQuery.attr(a,"selected");},text:function(a){return"text"=3D=3D= a.type;},radio:function(a){return"radio"=3D=3Da.type;},checkbox:function(= a){return"checkbox"=3D=3Da.type;},file:function(a){return"file"=3D=3Da.ty= pe;},password:function(a){return"password"=3D=3Da.type;},submit:function(= a){return"submit"=3D=3Da.type;},image:function(a){return"image"=3D=3Da.ty= pe;},reset:function(a){return"reset"=3D=3Da.type;},button:function(a){ret= urn"button"=3D=3Da.type||jQuery.nodeName(a,"button");},input:function(a){= return/input|select|textarea|button/i.test(a.nodeName);},has:function(a,i= ,m){return = jQuery.find(m[3],a).length;},header:function(a){return/h\d/i.test(a.nodeN= ame);},animated:function(a){return = jQuery.grep(jQuery.timers,function(fn){return = a=3D=3Dfn.elem;}).length;}}},parse:[/^(\[) *@?([\w-]+) *([!*$^~=3D]*) = *('?"?)(.*?)\4 *\]/,/^(:)([\w-]+)\("?'?(.*?(\(.*?\))?[^(]*?)"?'?\)/,new = RegExp("^([:.#]*)("+chars+"+)")],multiFilter:function(expr,elems,not){var= old,cur=3D[];while(expr&&expr!=3Dold){old=3Dexpr;var = f=3DjQuery.filter(expr,elems,not);expr=3Df.t.replace(/^\s*,\s*/,"");cur=3D= not?elems=3Df.r:jQuery.merge(cur,f.r);}return = cur;},find:function(t,context){if(typeof = t!=3D"string")return[t];if(context&&context.nodeType!=3D1&&context.nodeTy= pe!=3D9)return[];context=3Dcontext||document;var = ret=3D[context],done=3D[],last,nodeName;while(t&&last!=3Dt){var = r=3D[];last=3Dt;t=3DjQuery.trim(t);var = foundToken=3Dfalse,re=3DquickChild,m=3Dre.exec(t);if(m){nodeName=3Dm[1].t= oUpperCase();for(var i=3D0;ret[i];i++)for(var = c=3Dret[i].firstChild;c;c=3Dc.nextSibling)if(c.nodeType=3D=3D1&&(nodeName= =3D=3D"*"||c.nodeName.toUpperCase()=3D=3DnodeName))r.push(c);ret=3Dr;t=3D= t.replace(re,"");if(t.indexOf(" = ")=3D=3D0)continue;foundToken=3Dtrue;}else{re=3D/^([>+~])\s*(\w*)/i;if((m= =3Dre.exec(t))!=3Dnull){r=3D[];var = merge=3D{};nodeName=3Dm[2].toUpperCase();m=3Dm[1];for(var = j=3D0,rl=3Dret.length;j=3D0)^not)tmp.= push(a);}r=3Dtmp;}else if(m[1]=3D=3D":"&&m[2]=3D=3D"nth-child"){var = merge=3D{},tmp=3D[],test=3D/(-?)(\d*)n((?:\+|-)?\d*)/.exec(m[3]=3D=3D"eve= n"&&"2n"||m[3]=3D=3D"odd"&&"2n+1"||!/\D/.test(m[3])&&"0n+"+m[3]||m[3]),fi= rst=3D(test[1]+(test[2]||1))-0,last=3Dtest[3]-0;for(var = i=3D0,rl=3Dr.length;i=3D0)a= dd=3Dtrue;if(add^not)tmp.push(node);}r=3Dtmp;}else{var = fn=3DjQuery.expr[m[1]];if(typeof = fn=3D=3D"object")fn=3Dfn[m[2]];if(typeof = fn=3D=3D"string")fn=3Deval("false||function(a,i){return = "+fn+";}");r=3DjQuery.grep(r,function(elem,i){return = fn(elem,i,m,r);},not);}}return{r:r,t:t};},dir:function(elem,dir){var = matched=3D[],cur=3Delem[dir];while(cur&&cur!=3Ddocument){if(cur.nodeType=3D= =3D1)matched.push(cur);cur=3Dcur[dir];}return = matched;},nth:function(cur,result,dir,elem){result=3Dresult||1;var = num=3D0;for(;cur;cur=3Dcur[dir])if(cur.nodeType=3D=3D1&&++num=3D=3Dresult= )break;return cur;},sibling:function(n,elem){var = r=3D[];for(;n;n=3Dn.nextSibling){if(n.nodeType=3D=3D1&&n!=3Delem)r.push(n= );}return = r;}});jQuery.event=3D{add:function(elem,types,handler,data){if(elem.nodeT= ype=3D=3D3||elem.nodeType=3D=3D8)return;if(jQuery.browser.msie&&elem.setI= nterval)elem=3Dwindow;if(!handler.guid)handler.guid=3Dthis.guid++;if(data= !=3Dundefined){var = fn=3Dhandler;handler=3Dthis.proxy(fn,function(){return = fn.apply(this,arguments);});handler.data=3Ddata;}var = events=3DjQuery.data(elem,"events")||jQuery.data(elem,"events",{}),handle= =3DjQuery.data(elem,"handle")||jQuery.data(elem,"handle",function(){if(ty= peof jQuery!=3D"undefined"&&!jQuery.event.triggered)return = jQuery.event.handle.apply(arguments.callee.elem,arguments);});handle.elem= =3Delem;jQuery.each(types.split(/\s+/),function(index,type){var = parts=3Dtype.split(".");type=3Dparts[0];handler.type=3Dparts[1];var = handlers=3Devents[type];if(!handlers){handlers=3Devents[type]=3D{};if(!jQ= uery.event.special[type]||jQuery.event.special[type].setup.call(elem)=3D=3D= =3Dfalse){if(elem.addEventListener)elem.addEventListener(type,handle,fals= e);else = if(elem.attachEvent)elem.attachEvent("on"+type,handle);}}handlers[handler= .guid]=3Dhandler;jQuery.event.global[type]=3Dtrue;});elem=3Dnull;},guid:1= ,global:{},remove:function(elem,types,handler){if(elem.nodeType=3D=3D3||e= lem.nodeType=3D=3D8)return;var = events=3DjQuery.data(elem,"events"),ret,index;if(events){if(types=3D=3Dun= defined||(typeof types=3D=3D"string"&&types.charAt(0)=3D=3D"."))for(var = type in = events)this.remove(elem,type+(types||""));else{if(types.type){handler=3Dt= ypes.handler;types=3Dtypes.type;}jQuery.each(types.split(/\s+/),function(= index,type){var = parts=3Dtype.split(".");type=3Dparts[0];if(events[type]){if(handler)delet= e events[type][handler.guid];else=0A= for(handler in = events[type])if(!parts[1]||events[type][handler].type=3D=3Dparts[1])delet= e events[type][handler];for(ret in = events[type])break;if(!ret){if(!jQuery.event.special[type]||jQuery.event.= special[type].teardown.call(elem)=3D=3D=3Dfalse){if(elem.removeEventListe= ner)elem.removeEventListener(type,jQuery.data(elem,"handle"),false);else = if(elem.detachEvent)elem.detachEvent("on"+type,jQuery.data(elem,"handle")= );}ret=3Dnull;delete events[type];}}});}for(ret in = events)break;if(!ret){var = handle=3DjQuery.data(elem,"handle");if(handle)handle.elem=3Dnull;jQuery.r= emoveData(elem,"events");jQuery.removeData(elem,"handle");}}},trigger:fun= ction(type,data,elem,donative,extra){data=3DjQuery.makeArray(data);if(typ= e.indexOf("!")>=3D0){type=3Dtype.slice(0,-1);var = exclusive=3Dtrue;}if(!elem){if(this.global[type])jQuery("*").add([window,= document]).trigger(type,data);}else{if(elem.nodeType=3D=3D3||elem.nodeTyp= e=3D=3D8)return undefined;var = val,ret,fn=3DjQuery.isFunction(elem[type]||null),event=3D!data[0]||!data[= 0].preventDefault;if(event){data.unshift({type:type,target:elem,preventDe= fault:function(){},stopPropagation:function(){},timeStamp:now()});data[0]= [expando]=3Dtrue;}data[0].type=3Dtype;if(exclusive)data[0].exclusive=3Dtr= ue;var = handle=3DjQuery.data(elem,"handle");if(handle)val=3Dhandle.apply(elem,dat= a);if((!fn||(jQuery.nodeName(elem,'a')&&type=3D=3D"click"))&&elem["on"+ty= pe]&&elem["on"+type].apply(elem,data)=3D=3D=3Dfalse)val=3Dfalse;if(event)= data.shift();if(extra&&jQuery.isFunction(extra)){ret=3Dextra.apply(elem,v= al=3D=3Dnull?data:data.concat(val));if(ret!=3D=3Dundefined)val=3Dret;}if(= fn&&donative!=3D=3Dfalse&&val!=3D=3Dfalse&&!(jQuery.nodeName(elem,'a')&&t= ype=3D=3D"click")){this.triggered=3Dtrue;try{elem[type]();}catch(e){}}thi= s.triggered=3Dfalse;}return val;},handle:function(event){var = val,ret,namespace,all,handlers;event=3Darguments[0]=3DjQuery.event.fix(ev= ent||window.event);namespace=3Devent.type.split(".");event.type=3Dnamespa= ce[0];namespace=3Dnamespace[1];all=3D!namespace&&!event.exclusive;handler= s=3D(jQuery.data(this,"events")||{})[event.type];for(var j in = handlers){var = handler=3Dhandlers[j];if(all||handler.type=3D=3Dnamespace){event.handler=3D= handler;event.data=3Dhandler.data;ret=3Dhandler.apply(this,arguments);if(= val!=3D=3Dfalse)val=3Dret;if(ret=3D=3D=3Dfalse){event.preventDefault();ev= ent.stopPropagation();}}}return = val;},fix:function(event){if(event[expando]=3D=3Dtrue)return event;var = originalEvent=3Devent;event=3D{originalEvent:originalEvent};var = props=3D"altKey attrChange attrName bubbles button cancelable charCode = clientX clientY ctrlKey currentTarget data detail eventPhase fromElement = handler keyCode metaKey newValue originalTarget pageX pageY prevValue = relatedNode relatedTarget screenX screenY shiftKey srcElement target = timeStamp toElement type view wheelDelta which".split(" ");for(var = i=3Dprops.length;i;i--)event[props[i]]=3DoriginalEvent[props[i]];event[ex= pando]=3Dtrue;event.preventDefault=3Dfunction(){if(originalEvent.preventD= efault)originalEvent.preventDefault();originalEvent.returnValue=3Dfalse;}= ;event.stopPropagation=3Dfunction(){if(originalEvent.stopPropagation)orig= inalEvent.stopPropagation();originalEvent.cancelBubble=3Dtrue;};event.tim= eStamp=3Devent.timeStamp||now();if(!event.target)event.target=3Devent.src= Element||document;if(event.target.nodeType=3D=3D3)event.target=3Devent.ta= rget.parentNode;if(!event.relatedTarget&&event.fromElement)event.relatedT= arget=3Devent.fromElement=3D=3Devent.target?event.toElement:event.fromEle= ment;if(event.pageX=3D=3Dnull&&event.clientX!=3Dnull){var = doc=3Ddocument.documentElement,body=3Ddocument.body;event.pageX=3Devent.c= lientX+(doc&&doc.scrollLeft||body&&body.scrollLeft||0)-(doc.clientLeft||0= );event.pageY=3Devent.clientY+(doc&&doc.scrollTop||body&&body.scrollTop||= 0)-(doc.clientTop||0);}if(!event.which&&((event.charCode||event.charCode=3D= =3D=3D0)?event.charCode:event.keyCode))event.which=3Devent.charCode||even= t.keyCode;if(!event.metaKey&&event.ctrlKey)event.metaKey=3Devent.ctrlKey;= if(!event.which&&event.button)event.which=3D(event.button&1?1:(event.butt= on&2?3:(event.button&4?2:0)));return = event;},proxy:function(fn,proxy){proxy.guid=3Dfn.guid=3Dfn.guid||proxy.gu= id||this.guid++;return = proxy;},special:{ready:{setup:function(){bindReady();return;},teardown:fu= nction(){return;}},mouseenter:{setup:function(){if(jQuery.browser.msie)re= turn = false;jQuery(this).bind("mouseover",jQuery.event.special.mouseenter.handl= er);return true;},teardown:function(){if(jQuery.browser.msie)return = false;jQuery(this).unbind("mouseover",jQuery.event.special.mouseenter.han= dler);return = true;},handler:function(event){if(withinElement(event,this))return = true;event.type=3D"mouseenter";return = jQuery.event.handle.apply(this,arguments);}},mouseleave:{setup:function()= {if(jQuery.browser.msie)return = false;jQuery(this).bind("mouseout",jQuery.event.special.mouseleave.handle= r);return true;},teardown:function(){if(jQuery.browser.msie)return = false;jQuery(this).unbind("mouseout",jQuery.event.special.mouseleave.hand= ler);return = true;},handler:function(event){if(withinElement(event,this))return = true;event.type=3D"mouseleave";return = jQuery.event.handle.apply(this,arguments);}}}};jQuery.fn.extend({bind:fun= ction(type,data,fn){return = type=3D=3D"unload"?this.one(type,data,fn):this.each(function(){jQuery.eve= nt.add(this,type,fn||data,fn&&data);});},one:function(type,data,fn){var = one=3DjQuery.event.proxy(fn||data,function(event){jQuery(this).unbind(eve= nt,one);return(fn||data).apply(this,arguments);});return = this.each(function(){jQuery.event.add(this,type,one,fn&&data);});},unbind= :function(type,fn){return = this.each(function(){jQuery.event.remove(this,type,fn);});},trigger:funct= ion(type,data,fn){return = this.each(function(){jQuery.event.trigger(type,data,this,true,fn);});},tr= iggerHandler:function(type,data,fn){return = this[0]&&jQuery.event.trigger(type,data,this[0],false,fn);},toggle:functi= on(fn){var = args=3Darguments,i=3D1;while(i=3D0){var = selector=3Durl.slice(off,url.length);url=3Durl.slice(0,off);}callback=3Dc= allback||function(){};var = type=3D"GET";if(params)if(jQuery.isFunction(params)){callback=3Dparams;pa= rams=3Dnull;}else{params=3DjQuery.param(params);type=3D"POST";}var = self=3Dthis;jQuery.ajax({url:url,type:type,dataType:"html",data:params,co= mplete:function(res,status){if(status=3D=3D"success"||status=3D=3D"notmod= ified")self.html(selector?jQuery("
").append(res.responseText.replac= e(//g,"")).find(selector):res.responseText);self.= each(callback,[res.responseText,status,res]);}});return = this;},serialize:function(){return = jQuery.param(this.serializeArray());},serializeArray:function(){return = this.map(function(){return = jQuery.nodeName(this,"form")?jQuery.makeArray(this.elements):this;}).filt= er(function(){return = this.name&&!this.disabled&&(this.checked||/select|textarea/i.test(this.no= deName)||/text|hidden|password/i.test(this.type));}).map(function(i,elem)= {var val=3DjQuery(this).val();return = val=3D=3Dnull?null:val.constructor=3D=3DArray?jQuery.map(val,function(val= ,i){return{name:elem.name,value:val};}):{name:elem.name,value:val};}).get= ();}});jQuery.each("ajaxStart,ajaxStop,ajaxComplete,ajaxError,ajaxSuccess= ,ajaxSend".split(","),function(i,o){jQuery.fn[o]=3Dfunction(f){return = this.bind(o,f);};});var = jsc=3Dnow();jQuery.extend({get:function(url,data,callback,type){if(jQuery= .isFunction(data)){callback=3Ddata;data=3Dnull;}return = jQuery.ajax({type:"GET",url:url,data:data,success:callback,dataType:type}= );},getScript:function(url,callback){return = jQuery.get(url,null,callback,"script");},getJSON:function(url,data,callba= ck){return = jQuery.get(url,data,callback,"json");},post:function(url,data,callback,ty= pe){if(jQuery.isFunction(data)){callback=3Ddata;data=3D{};}return = jQuery.ajax({type:"POST",url:url,data:data,success:callback,dataType:type= });},ajaxSetup:function(settings){jQuery.extend(jQuery.ajaxSettings,setti= ngs);},ajaxSettings:{url:location.href,global:true,type:"GET",timeout:0,c= ontentType:"application/x-www-form-urlencoded",processData:true,async:tru= e,data:null,username:null,password:null,accepts:{xml:"application/xml, = text/xml",html:"text/html",script:"text/javascript, = application/javascript",json:"application/json, = text/javascript",text:"text/plain",_default:"*/*"}},lastModified:{},ajax:= function(s){s=3DjQuery.extend(true,s,jQuery.extend(true,{},jQuery.ajaxSet= tings,s));var = jsonp,jsre=3D/=3D\?(&|$)/g,status,data,type=3Ds.type.toUpperCase();if(s.d= ata&&s.processData&&typeof = s.data!=3D"string")s.data=3DjQuery.param(s.data);if(s.dataType=3D=3D"json= p"){if(type=3D=3D"GET"){if(!s.url.match(jsre))s.url+=3D(s.url.match(/\?/)= ?"&":"?")+(s.jsonp||"callback")+"=3D?";}else = if(!s.data||!s.data.match(jsre))s.data=3D(s.data?s.data+"&":"")+(s.jsonp|= |"callback")+"=3D?";s.dataType=3D"json";}if(s.dataType=3D=3D"json"&&(s.da= ta&&s.data.match(jsre)||s.url.match(jsre))){jsonp=3D"jsonp"+jsc++;if(s.da= ta)s.data=3D(s.data+"").replace(jsre,"=3D"+jsonp+"$1");s.url=3Ds.url.repl= ace(jsre,"=3D"+jsonp+"$1");s.dataType=3D"script";window[jsonp]=3Dfunction= (tmp){data=3Dtmp;success();complete();window[jsonp]=3Dundefined;try{delet= e = window[jsonp];}catch(e){}if(head)head.removeChild(script);};}if(s.dataTyp= e=3D=3D"script"&&s.cache=3D=3Dnull)s.cache=3Dfalse;if(s.cache=3D=3D=3Dfal= se&&type=3D=3D"GET"){var ts=3Dnow();var = ret=3Ds.url.replace(/(\?|&)_=3D.*?(&|$)/,"$1_=3D"+ts+"$2");s.url=3Dret+((= ret=3D=3Ds.url)?(s.url.match(/\?/)?"&":"?")+"_=3D"+ts:"");}if(s.data&&typ= e=3D=3D"GET"){s.url+=3D(s.url.match(/\?/)?"&":"?")+s.data;s.data=3Dnull;}= if(s.global&&!jQuery.active++)jQuery.event.trigger("ajaxStart");var = remote=3D/^(?:\w+:)?\/\/([^\/?#]+)/;if(s.dataType=3D=3D"script"&&type=3D=3D= "GET"&&remote.test(s.url)&&remote.exec(s.url)[1]!=3Dlocation.host){var = head=3Ddocument.getElementsByTagName("head")[0];var = script=3Ddocument.createElement("script");script.src=3Ds.url;if(s.scriptC= harset)script.charset=3Ds.scriptCharset;if(!jsonp){var = done=3Dfalse;script.onload=3Dscript.onreadystatechange=3Dfunction(){if(!d= one&&(!this.readyState||this.readyState=3D=3D"loaded"||this.readyState=3D= =3D"complete")){done=3Dtrue;success();complete();head.removeChild(script)= ;}};}head.appendChild(script);return undefined;}var = requestDone=3Dfalse;var xhr=3Dwindow.ActiveXObject?new = ActiveXObject("Microsoft.XMLHTTP"):new = XMLHttpRequest();if(s.username)xhr.open(type,s.url,s.async,s.username,s.p= assword);else=0A= xhr.open(type,s.url,s.async);try{if(s.data)xhr.setRequestHeader("Content-= Type",s.contentType);if(s.ifModified)xhr.setRequestHeader("If-Modified-Si= nce",jQuery.lastModified[s.url]||"Thu, 01 Jan 1970 00:00:00 = GMT");xhr.setRequestHeader("X-Requested-With","XMLHttpRequest");xhr.setRe= questHeader("Accept",s.dataType&&s.accepts[s.dataType]?s.accepts[s.dataTy= pe]+", = */*":s.accepts._default);}catch(e){}if(s.beforeSend&&s.beforeSend(xhr,s)=3D= =3D=3Dfalse){s.global&&jQuery.active--;xhr.abort();return = false;}if(s.global)jQuery.event.trigger("ajaxSend",[xhr,s]);var = onreadystatechange=3Dfunction(isTimeout){if(!requestDone&&xhr&&(xhr.ready= State=3D=3D4||isTimeout=3D=3D"timeout")){requestDone=3Dtrue;if(ival){clea= rInterval(ival);ival=3Dnull;}status=3DisTimeout=3D=3D"timeout"&&"timeout"= ||!jQuery.httpSuccess(xhr)&&"error"||s.ifModified&&jQuery.httpNotModified= (xhr,s.url)&&"notmodified"||"success";if(status=3D=3D"success"){try{data=3D= jQuery.httpData(xhr,s.dataType,s.dataFilter);}catch(e){status=3D"parserer= ror";}}if(status=3D=3D"success"){var = modRes;try{modRes=3Dxhr.getResponseHeader("Last-Modified");}catch(e){}if(= s.ifModified&&modRes)jQuery.lastModified[s.url]=3DmodRes;if(!jsonp)succes= s();}else=0A= jQuery.handleError(s,xhr,status);complete();if(s.async)xhr=3Dnull;}};if(s= .async){var = ival=3DsetInterval(onreadystatechange,13);if(s.timeout>0)setTimeout(funct= ion(){if(xhr){xhr.abort();if(!requestDone)onreadystatechange("timeout");}= },s.timeout);}try{xhr.send(s.data);}catch(e){jQuery.handleError(s,xhr,nul= l,e);}if(!s.async)onreadystatechange();function = success(){if(s.success)s.success(data,status);if(s.global)jQuery.event.tr= igger("ajaxSuccess",[xhr,s]);}function = complete(){if(s.complete)s.complete(xhr,status);if(s.global)jQuery.event.= trigger("ajaxComplete",[xhr,s]);if(s.global&&!--jQuery.active)jQuery.even= t.trigger("ajaxStop");}return = xhr;},handleError:function(s,xhr,status,e){if(s.error)s.error(xhr,status,= e);if(s.global)jQuery.event.trigger("ajaxError",[xhr,s,e]);},active:0,htt= pSuccess:function(xhr){try{return!xhr.status&&location.protocol=3D=3D"fil= e:"||(xhr.status>=3D200&&xhr.status<300)||xhr.status=3D=3D304||xhr.status= =3D=3D1223||jQuery.browser.safari&&xhr.status=3D=3Dundefined;}catch(e){}r= eturn false;},httpNotModified:function(xhr,url){try{var = xhrRes=3Dxhr.getResponseHeader("Last-Modified");return = xhr.status=3D=3D304||xhrRes=3D=3DjQuery.lastModified[url]||jQuery.browser= .safari&&xhr.status=3D=3Dundefined;}catch(e){}return = false;},httpData:function(xhr,type,filter){var = ct=3Dxhr.getResponseHeader("content-type"),xml=3Dtype=3D=3D"xml"||!type&&= ct&&ct.indexOf("xml")>=3D0,data=3Dxml?xhr.responseXML:xhr.responseText;if= (xml&&data.documentElement.tagName=3D=3D"parsererror")throw"parsererror";= if(filter)data=3Dfilter(data,type);if(type=3D=3D"script")jQuery.globalEva= l(data);if(type=3D=3D"json")data=3Deval("("+data+")");return = data;},param:function(a){var = s=3D[];if(a.constructor=3D=3DArray||a.jquery)jQuery.each(a,function(){s.p= ush(encodeURIComponent(this.name)+"=3D"+encodeURIComponent(this.value));}= );else=0A= for(var j in = a)if(a[j]&&a[j].constructor=3D=3DArray)jQuery.each(a[j],function(){s.push= (encodeURIComponent(j)+"=3D"+encodeURIComponent(this));});else=0A= s.push(encodeURIComponent(j)+"=3D"+encodeURIComponent(jQuery.isFunction(a= [j])?a[j]():a[j]));return = s.join("&").replace(/%20/g,"+");}});jQuery.fn.extend({show:function(speed= ,callback){return = speed?this.animate({height:"show",width:"show",opacity:"show"},speed,call= back):this.filter(":hidden").each(function(){this.style.display=3Dthis.ol= dblock||"";if(jQuery.css(this,"display")=3D=3D"none"){var = elem=3DjQuery("<"+this.tagName+" = />").appendTo("body");this.style.display=3Delem.css("display");if(this.st= yle.display=3D=3D"none")this.style.display=3D"block";elem.remove();}}).en= d();},hide:function(speed,callback){return = speed?this.animate({height:"hide",width:"hide",opacity:"hide"},speed,call= back):this.filter(":visible").each(function(){this.oldblock=3Dthis.oldblo= ck||jQuery.css(this,"display");this.style.display=3D"none";}).end();},_to= ggle:jQuery.fn.toggle,toggle:function(fn,fn2){return = jQuery.isFunction(fn)&&jQuery.isFunction(fn2)?this._toggle.apply(this,arg= uments):fn?this.animate({height:"toggle",width:"toggle",opacity:"toggle"}= ,fn,fn2):this.each(function(){jQuery(this)[jQuery(this).is(":hidden")?"sh= ow":"hide"]();});},slideDown:function(speed,callback){return = this.animate({height:"show"},speed,callback);},slideUp:function(speed,cal= lback){return = this.animate({height:"hide"},speed,callback);},slideToggle:function(speed= ,callback){return = this.animate({height:"toggle"},speed,callback);},fadeIn:function(speed,ca= llback){return = this.animate({opacity:"show"},speed,callback);},fadeOut:function(speed,ca= llback){return = this.animate({opacity:"hide"},speed,callback);},fadeTo:function(speed,to,= callback){return = this.animate({opacity:to},speed,callback);},animate:function(prop,speed,e= asing,callback){var optall=3DjQuery.speed(speed,easing,callback);return = this[optall.queue=3D=3D=3Dfalse?"each":"queue"](function(){if(this.nodeTy= pe!=3D1)return false;var = opt=3DjQuery.extend({},optall),p,hidden=3DjQuery(this).is(":hidden"),self= =3Dthis;for(p in = prop){if(prop[p]=3D=3D"hide"&&hidden||prop[p]=3D=3D"show"&&!hidden)return= = opt.complete.call(this);if(p=3D=3D"height"||p=3D=3D"width"){opt.display=3D= jQuery.css(this,"display");opt.overflow=3Dthis.style.overflow;}}if(opt.ov= erflow!=3Dnull)this.style.overflow=3D"hidden";opt.curAnim=3DjQuery.extend= ({},prop);jQuery.each(prop,function(name,val){var e=3Dnew = jQuery.fx(self,opt,name);if(/toggle|show|hide/.test(val))e[val=3D=3D"togg= le"?hidden?"show":"hide":val](prop);else{var = parts=3Dval.toString().match(/^([+-]=3D)?([\d+-.]+)(.*)$/),start=3De.cur(= true)||0;if(parts){var = end=3DparseFloat(parts[2]),unit=3Dparts[3]||"px";if(unit!=3D"px"){self.st= yle[name]=3D(end||1)+unit;start=3D((end||1)/e.cur(true))*start;self.style= [name]=3Dstart+unit;}if(parts[1])end=3D((parts[1]=3D=3D"-=3D"?-1:1)*end)+= start;e.custom(start,end,unit);}else=0A= e.custom(start,val,"");}});return = true;});},queue:function(type,fn){if(jQuery.isFunction(type)||(type&&type= .constructor=3D=3DArray)){fn=3Dtype;type=3D"fx";}if(!type||(typeof = type=3D=3D"string"&&!fn))return queue(this[0],type);return = this.each(function(){if(fn.constructor=3D=3DArray)queue(this,type,fn);els= e{queue(this,type).push(fn);if(queue(this,type).length=3D=3D1)fn.call(thi= s);}});},stop:function(clearQueue,gotoEnd){var = timers=3DjQuery.timers;if(clearQueue)this.queue([]);this.each(function(){= for(var = i=3Dtimers.length-1;i>=3D0;i--)if(timers[i].elem=3D=3Dthis){if(gotoEnd)ti= mers[i](true);timers.splice(i,1);}});if(!gotoEnd)this.dequeue();return = this;}});var = queue=3Dfunction(elem,type,array){if(elem){type=3Dtype||"fx";var = q=3DjQuery.data(elem,type+"queue");if(!q||array)q=3DjQuery.data(elem,type= +"queue",jQuery.makeArray(array));}return = q;};jQuery.fn.dequeue=3Dfunction(type){type=3Dtype||"fx";return = this.each(function(){var = q=3Dqueue(this,type);q.shift();if(q.length)q[0].call(this);});};jQuery.ex= tend({speed:function(speed,easing,fn){var = opt=3Dspeed&&speed.constructor=3D=3DObject?speed:{complete:fn||!fn&&easin= g||jQuery.isFunction(speed)&&speed,duration:speed,easing:fn&&easing||easi= ng&&easing.constructor!=3DFunction&&easing};opt.duration=3D(opt.duration&= &opt.duration.constructor=3D=3DNumber?opt.duration:jQuery.fx.speeds[opt.d= uration])||jQuery.fx.speeds.def;opt.old=3Dopt.complete;opt.complete=3Dfun= ction(){if(opt.queue!=3D=3Dfalse)jQuery(this).dequeue();if(jQuery.isFunct= ion(opt.old))opt.old.call(this);};return = opt;},easing:{linear:function(p,n,firstNum,diff){return = firstNum+diff*p;},swing:function(p,n,firstNum,diff){return((-Math.cos(p*M= ath.PI)/2)+0.5)*diff+firstNum;}},timers:[],timerId:null,fx:function(elem,= options,prop){this.options=3Doptions;this.elem=3Delem;this.prop=3Dprop;if= (!options.orig)options.orig=3D{};}});jQuery.fx.prototype=3D{update:functi= on(){if(this.options.step)this.options.step.call(this.elem,this.now,this)= ;(jQuery.fx.step[this.prop]||jQuery.fx.step._default)(this);if(this.prop=3D= =3D"height"||this.prop=3D=3D"width")this.elem.style.display=3D"block";},c= ur:function(force){if(this.elem[this.prop]!=3Dnull&&this.elem.style[this.= prop]=3D=3Dnull)return this.elem[this.prop];var = r=3DparseFloat(jQuery.css(this.elem,this.prop,force));return = r&&r>-10000?r:parseFloat(jQuery.curCSS(this.elem,this.prop))||0;},custom:= function(from,to,unit){this.startTime=3Dnow();this.start=3Dfrom;this.end=3D= to;this.unit=3Dunit||this.unit||"px";this.now=3Dthis.start;this.pos=3Dthi= s.state=3D0;this.update();var self=3Dthis;function t(gotoEnd){return = self.step(gotoEnd);}t.elem=3Dthis.elem;jQuery.timers.push(t);if(jQuery.ti= merId=3D=3Dnull){jQuery.timerId=3DsetInterval(function(){var = timers=3DjQuery.timers;for(var = i=3D0;ithis.options.duration+this.startTime){this.now=3D= this.end;this.pos=3Dthis.state=3D1;this.update();this.options.curAnim[thi= s.prop]=3Dtrue;var done=3Dtrue;for(var i in = this.options.curAnim)if(this.options.curAnim[i]!=3D=3Dtrue)done=3Dfalse;i= f(done){if(this.options.display!=3Dnull){this.elem.style.overflow=3Dthis.= options.overflow;this.elem.style.display=3Dthis.options.display;if(jQuery= .css(this.elem,"display")=3D=3D"none")this.elem.style.display=3D"block";}= if(this.options.hide)this.elem.style.display=3D"none";if(this.options.hid= e||this.options.show)for(var p in = this.options.curAnim)jQuery.attr(this.elem.style,p,this.options.orig[p]);= }if(done)this.options.complete.call(this.elem);return false;}else{var = n=3Dt-this.startTime;this.state=3Dn/this.options.duration;this.pos=3DjQue= ry.easing[this.options.easing||(jQuery.easing.swing?"swing":"linear")](th= is.state,n,0,1,this.options.duration);this.now=3Dthis.start+((this.end-th= is.start)*this.pos);this.update();}return = true;}};jQuery.extend(jQuery.fx,{speeds:{slow:600,fast:200,def:400},step:= {scrollLeft:function(fx){fx.elem.scrollLeft=3Dfx.now;},scrollTop:function= (fx){fx.elem.scrollTop=3Dfx.now;},opacity:function(fx){jQuery.attr(fx.ele= m.style,"opacity",fx.now);},_default:function(fx){fx.elem.style[fx.prop]=3D= fx.now+fx.unit;}}});jQuery.fn.offset=3Dfunction(){var = left=3D0,top=3D0,elem=3Dthis[0],results;if(elem)with(jQuery.browser){var = parent=3Delem.parentNode,offsetChild=3Delem,offsetParent=3Delem.offsetPar= ent,doc=3Delem.ownerDocument,safari2=3Dsafari&&parseInt(version)<522&&!/a= dobeair/i.test(userAgent),css=3DjQuery.curCSS,fixed=3Dcss(elem,"position"= )=3D=3D"fixed";if(elem.getBoundingClientRect){var = box=3Delem.getBoundingClientRect();add(box.left+Math.max(doc.documentElem= ent.scrollLeft,doc.body.scrollLeft),box.top+Math.max(doc.documentElement.= scrollTop,doc.body.scrollTop));add(-doc.documentElement.clientLeft,-doc.d= ocumentElement.clientTop);}else{add(elem.offsetLeft,elem.offsetTop);while= (offsetParent){add(offsetParent.offsetLeft,offsetParent.offsetTop);if(moz= illa&&!/^t(able|d|h)$/i.test(offsetParent.tagName)||safari&&!safari2)bord= er(offsetParent);if(!fixed&&css(offsetParent,"position")=3D=3D"fixed")fix= ed=3Dtrue;offsetChild=3D/^body$/i.test(offsetParent.tagName)?offsetChild:= offsetParent;offsetParent=3DoffsetParent.offsetParent;}while(parent&&pare= nt.tagName&&!/^body|html$/i.test(parent.tagName)){if(!/^inline|table.*$/i= .test(css(parent,"display")))add(-parent.scrollLeft,-parent.scrollTop);if= (mozilla&&css(parent,"overflow")!=3D"visible")border(parent);parent=3Dpar= ent.parentNode;}if((safari2&&(fixed||css(offsetChild,"position")=3D=3D"ab= solute"))||(mozilla&&css(offsetChild,"position")!=3D"absolute"))add(-doc.= body.offsetLeft,-doc.body.offsetTop);if(fixed)add(Math.max(doc.documentEl= ement.scrollLeft,doc.body.scrollLeft),Math.max(doc.documentElement.scroll= Top,doc.body.scrollTop));}results=3D{top:top,left:left};}function = border(elem){add(jQuery.curCSS(elem,"borderLeftWidth",true),jQuery.curCSS= (elem,"borderTopWidth",true));}function = add(l,t){left+=3DparseInt(l,10)||0;top+=3DparseInt(t,10)||0;}return = results;};jQuery.fn.extend({position:function(){var = left=3D0,top=3D0,results;if(this[0]){var = offsetParent=3Dthis.offsetParent(),offset=3Dthis.offset(),parentOffset=3D= /^body|html$/i.test(offsetParent[0].tagName)?{top:0,left:0}:offsetParent.= offset();offset.top-=3Dnum(this,'marginTop');offset.left-=3Dnum(this,'mar= ginLeft');parentOffset.top+=3Dnum(offsetParent,'borderTopWidth');parentOf= fset.left+=3Dnum(offsetParent,'borderLeftWidth');results=3D{top:offset.to= p-parentOffset.top,left:offset.left-parentOffset.left};}return = results;},offsetParent:function(){var = offsetParent=3Dthis[0].offsetParent;while(offsetParent&&(!/^body|html$/i.= test(offsetParent.tagName)&&jQuery.css(offsetParent,'position')=3D=3D'sta= tic'))offsetParent=3DoffsetParent.offsetParent;return = jQuery(offsetParent);}});jQuery.each(['Left','Top'],function(i,name){var = method=3D'scroll'+name;jQuery.fn[method]=3Dfunction(val){if(!this[0])retu= rn;return = val!=3Dundefined?this.each(function(){this=3D=3Dwindow||this=3D=3Ddocumen= t?window.scrollTo(!i?val:jQuery(window).scrollLeft(),i?val:jQuery(window)= .scrollTop()):this[method]=3Dval;}):this[0]=3D=3Dwindow||this[0]=3D=3Ddoc= ument?self[i?'pageYOffset':'pageXOffset']||jQuery.boxModel&&document.docu= mentElement[method]||document.body[method]:this[0][method];};});jQuery.ea= ch(["Height","Width"],function(i,name){var = tl=3Di?"Left":"Top",br=3Di?"Right":"Bottom";jQuery.fn["inner"+name]=3Dfun= ction(){return = this[name.toLowerCase()]()+num(this,"padding"+tl)+num(this,"padding"+br);= };jQuery.fn["outer"+name]=3Dfunction(margin){return = this["inner"+name]()+num(this,"border"+tl+"Width")+num(this,"border"+br+"= Width")+(margin?num(this,"margin"+tl)+num(this,"margin"+br):0);};});})(); ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/js/genlink.js function get_link(a, b) {=0A= document.write("" + b = + "");=0A= }=0A= =0A= function get_pdf_link(a, b, c) {=0A= document.writeln('' + b + = ' (Size: ' + c + 'K)');=0A= }=0A= =0A= function get_button_link(cgi, params, imgbutton) {=0A= document.writeln('3D"Click');=0A= }=0A= =0A= function get_text_link(url, linktext)=0A= {=0A= document.writeln('' + = linktext + '');=0A= }=0A= =0A= function get_htmlftext_link(a, b) {=0A= document.writeln("" + = b + ", ");=0A= }=0A= =0A= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/js/personalisation.js /*=0A= * Project : Interscience Redesign=0A= * File : personalisation.js=0A= * Creation Date : 25th March 2003=0A= * Author : Jonathan Sugar=0A= *=0A= * Various functions to deliver personalisation functionality.=0A= */=0A= =0A= // Pre-declare userName so it's available when we need to test if the = page=0A= // assembler ran OK=0A= var userName =3D null;=0A= var shcrtCookie =3D null;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Factory Methods=0A= =0A= // Simple wraper object to encapsulate the data for a co-branding item.=0A= function coBrandingItem(image, imageAltText, href)=0A= {=0A= //alert("Making new coBrandingItem:\nImage: " + image + = "\nimageAltText" + imageAltText + "\nhref: " + href);=0A= this.image =3D image;=0A= this.imageAltText =3D imageAltText;=0A= this.href =3D href;=0A= }=0A= =0A= /*=0A= * Insert the 'Customer co-branding' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert customer co branding. Loop through 'customerCoBranding' array=0A= * inserting XHTML where needed.=0A= *=0A= * NOTE: the array contains ONLY the resource location (the location of a = gif=0A= * on the file system), the required XHTML is then added where needed. = This way=0A= * we maintain the seperation between presentation and content.=0A= */=0A= function insertCustomerCoBranding(maxBranding)=0A= {=0A= if( customerCoBranding[0].image !=3D "none")=0A= {=0A= document.writeln('
');=0A= document.writeln('
3D"provided
');=0A= document.writeln('
    ');=0A= =0A= var i;=0A= //Change start for bug#2288=0A= if(typeof(maxBranding) =3D=3D "undefined" | maxBranding =3D=3D "" | = maxBranding =3D=3D 0){=0A= maxBranding =3D 3; // DEFAULT Value for No of Cobranding dispaly=0A= }=0A= var size =3D customerCoBranding.length;=0A= if(maxBranding !=3D -1 & size-1 > maxBranding){=0A= size =3D maxBranding;=0A= }=0A= //Change End for bug#2288=0A= =0A= // Add the co-branding images o the page.=0A= //for(i=3D0; i < customerCoBranding.length; i++ )=0A= for(i=3D0; i < size; i++ )=0A= {=0A= // ignore the terminating array element.=0A= if(customerCoBranding[i].image =3D=3D "none")=0A= {=0A= continue;=0A= }=0A= =0A= this.image =3D customerCoBranding[i].image;=0A= this.imageAltText =3D customerCoBranding[i].imageAltText;=0A= this.href =3D customerCoBranding[i].href;=0A= =0A= if (image =3D=3D "")=0A= {=0A= if(href =3D=3D "")=0A= {=0A= document.writeln('
  • ' + imageAltText + '
    • ');=0A= }=0A= else=0A= {=0A= document.writeln('
  • ' + imageAltText + = '
    • ');=0A= }=0A= }=0A= else=0A= {=0A= if(href =3D=3D "")=0A= {=0A= document.writeln('
  • 3D"'
    • ');=0A= }=0A= else=0A= {=0A= document.writeln('
  • 3D"'
    • ');=0A= }=0A= }=0A= }=0A= =0A= // If there are more co-branding images add in a link to them.=0A= // Changes made for Bug#2288=0A= //if(moreCustomerCoBranding =3D=3D "true")=0A= if(maxBranding !=3D -1 & customerCoBranding.length-1 > maxBranding)=0A= {=0A= document.writeln('
  • More Providers
    • ');=0A= }=0A= =0A= document.writeln('
');=0A= document.writeln('
');=0A= document.writeln('
3D""
');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the 'My Area' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= *=0A= * My profile link absolute as this file isnt only run from w3 anymore.=0A= */=0A= function insertMyArea(userdata)=0A= {=0A= // just in case the page assembler isn't running.=0A= =0A= =0A= if (userName !=3D null)=0A= {=0A= document.writeln("
    ");=0A= if(typeof(environment)!=3D'undefined' && environment!=3D'PRODUCTION')=0A= {=0A= if(userName !=3D "")=0A= {=0A= //write out the user specific data for the menu=0A= if (userdata !=3D null){=0A= if (userName.length > 33){=0A= var writedata =3D "
  • " + = userName.substring(0,33) + "..., access your
    • ";=0A= } else {=0A= var writedata =3D "
  • " + userName + = ", access your
    • ";=0A= }=0A= =0A= for (var x=3D0; xMy Profile"); =0A= } =0A= document.writeln(getLoginOutLink());=0A= //CR 3652 getAthenStatus() as added=0A= document.writeln(getAthenStatus());=0A= document.writeln("
");=0A= } else {=0A= if(typeof(environment)!=3D'undefined' && = environment=3D=3D'PRODUCTION') {=0A= document.writeln("
    ");=0A= if (userdata !=3D null){=0A= var writedata =3D "";=0A= for (var x=3D0; xLog Out");=0A= document.writeln("
"); =0A= }=0A= }=0A= if (menuloadedflag){=0A= wisMenu();=0A= }=0A= }=0A= =0A= /*=0A= * Insert the Customer Admin 'Login/Logout' link=0A= * -----------------------------=0A= *=0A= * Author: Bobby Jack, December 2004.=0A= *=0A= */=0A= function insertAdminLink(page)=0A= {=0A= val =3D getCookie("AID");=0A= =0A= if (val && val !=3D "-1")=0A= {=0A= document.writeln('
  • Logout');=0A= }=0A= else=0A= {=0A= document.writeln('
  • Login
    • ');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the username section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert the username.=0A= */=0A= function insertUserName()=0A= {=0A= document.write(userName);=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the login/logout cgi=0A= * ---------------------------------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= * Had to change the links absolute as this file isnt only run from w3 = anymore.=0A= */=0A= function getLoginOutLink()=0A= {=0A= if(userName !=3D "")=0A= {=0A= return "
  • Log Out
    • ";=0A= }else=0A= {=0A= return "
  • Log = In
    • ";=0A= }=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the shopping cart content page=0A= * ---------------------------------------------------=0A= *=0A= * Author: Zhiming & Warrell June 2007=0A= */=0A= function getShCrtLink(logged)=0A= {=0A= if(logged =3D=3D true )=0A= return "
    • ";=0A= else=0A= return "
    • ";=0A= }=0A= =0A= function toggleShCrtLink()=0A= {=0A= shcrtCookie =3D readCookie("SHCRT");=0A= if(shcrtCookie !=3D null)=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "block";=0A= }=0A= }=0A= else=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "none";=0A= }=0A= }=0A= }=0A= =0A= =0A= =0A= function readCookie(name)=0A= {=0A= var nameEQ =3D name + "=3D";=0A= var ca =3D document.cookie.split(';');=0A= for(var i=3D0; iYou are logged in = to Athens';=0A= }=0A= else=0A= {=0A= return "
  • Athens Log In
    • ";=0A= }=0A= =0A= } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/js/site.js /************************************************************************= ***************************=0A= FILE: site.js=0A= AUTHOR: Jonathan Sugar, Chris Neatby-Smith and Digital Pulp. July = 2003.=0A= =0A= DESCRIPTION: Javascript relating to site wide functionality across =0A= InterScience.=0A= =0A= INCLUDES FUNCTIONS=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Search Functions=0A= ----------------=0A= =0A= selectAndSubmit() - for deciding where to submit a query based on the = state of the form.=0A= processallContentSearch() - for validating form input for an all = content search.=0A= processTitleSearch() - for validating form input for a Title search.=0A= checkCitationSearch() - for validating the citation search form.=0A= selectAll() - check all the checkboxes in a form.=0A= do_popup() - stasa Acronym Finder window popup function.=0A= =0A= =0A= Other Functions=0A= ---------------=0A= =0A= fixInlineLists() - fix netscape 4.x bug where
  • tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src =3D"/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract  |  References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if ((isNaN(parseInt(itemID))=3D=3Dtrue)||(arguments.length >=3D 4 && = arguments[3] =3D=3D 'cluster'))=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= //check whether the last 2 arguments is used for urllink.=0A= // urllink is needed to open up mail form for mrw pages on tomcat = port=0A= if (arguments.length>=3D5 && = arguments[arguments.length-2]=3D=3D'urllink' && = arguments[arguments.length-1]!=3D'')=0A= {=0A= url =3D arguments[arguments.length-1] + url;=0A= }=0A= =0A= if (arguments.length>=3D5 && arguments[3]=3D=3D'currentlink' && = arguments[4]!=3D'')=0A= {=0A= url =3D url + '¤tLink=3D' + arguments[4];=0A= =0A= //processing specific cases=0A= if (arguments[4]=3D=3D'jcatalogjsphdr')=0A= {=0A= //get the issn and pass it the next stage for processing=0A= var currloc =3D location.href;=0A= var issnloc =3D currloc.indexOf("&issn=3D");=0A= if (issnloc !=3D -1)=0A= {=0A= url =3D url + '¤tISSN=3D' + = currloc.substring(issnloc+6);=0A= }=0A= }=0A= // issn is needed for cocoon rendered mrw to form the final url.=0A= else if ( (arguments[4]=3D=3D'cocoonmrwhome') || = (arguments[4]=3D=3D'cocoonmrwarticle') )=0A= {=0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'issn' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tISSN=3D' + arguments[6];=0A= }=0A= //getting the parameters of the currently shown mrw from the = url=0A= //the method used here is a little crude, it extracts the = values from the current url of the page the user is in =0A= //to pass it to the background program to reconstruct the = requred url=0A= if (arguments[4]=3D=3D'cocoonmrwhome')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= var mrwFileParam =3D mrwParamArr[6];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= mrwFileParam =3D = mrwFileParam.substring(0,seploc);=0A= }=0A= seploc =3D mrwFileParam.indexOf("?");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwUrlParam=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= =0A= }=0A= else if (arguments[4]=3D=3D'cocoonmrwarticle')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= url =3D url + '&mrwAid=3D' + mrwParamArr[7];=0A= url =3D url + '&mrwVersion=3D' + mrwParamArr[8];=0A= var mrwFileParam =3D mrwParamArr[9];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= }=0A= }=0A= }=0A= =0A= //checking if a html file exists in the url=0A= var tmpfname =3D location.href;=0A= var loc =3D tmpfname.indexOf("?");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(0,loc);=0A= }=0A= loc =3D tmpfname.indexOf(".html");=0A= if (loc !=3D -1)=0A= {=0A= loc =3D tmpfname.lastIndexOf("/");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(loc+1);=0A= url =3D url + '¤tFile=3D' + tmpfname;=0A= }=0A= }=0A= =0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'currentyear' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tYear=3D' + arguments[6];=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln('3D"blank"');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln('3D"blank"'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x" + = liels[j].innerHTML + "
  • You do not have = anything saved in this menu.
    • ";=0A= else=0A= tmpinnerhtml +=3D "
  • " = + liels[j].innerHTML + "
    • "; =0A= } =0A= } else {=0A= //setup var to see if more is required=0A= var more =3D (subnodeslength < lilength) ? true : = false; =0A= var flag =3D true;=0A= for (var j=3D0; j" + liels[j].innerHTML + = "";=0A= } else if (j > lilength-3){=0A= if (j =3D=3D lilength-2){=0A= var url =3D liels[j].innerHTML.split('"')[1];=0A= tmpinnerhtml +=3D "
  • more...
  • " + liels[j].innerHTML + "
    • ";=0A= } else {=0A= tmpinnerhtml +=3D "
  • " + liels[j].innerHTML + = "
    • "; =0A= } =0A= } =0A= }=0A= // set last two menu items to have no rollover and = a border at the top =0A= }=0A= menu.childNodes[x].childNodes[y].innerHTML =3D = tmpinnerhtml;=0A= // set default menu elements with diff style=0A= if (flag){=0A= if (more){=0A= liels[liels.length-3].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-3].className =3D "noroll";=0A= liels[liels.length-2].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-2].className =3D "noroll";=0A= liels[liels.length-1].className =3D "noroll";=0A= more =3D false;=0A= } else {=0A= liels[liels.length-2].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-2].className =3D "noroll";=0A= liels[liels.length-1].className =3D "noroll";=0A= } =0A= flag =3D false; =0A= } =0A= =0A= // set sub menu title for the msnu=0A= liels[0].className =3D "hoverTitle";=0A= // apply rollover functions to hide/show sub menus=0A= if (classname =3D=3D "menuDOM"){=0A= menu.childNodes[x].onmouseover =3D function(){=0A= // safari doesnt handle auto in absoulte = positioning correctly so this code makes the menus display correctly.=0A= if (navigator.userAgent.indexOf("Safari") !=3D -1){=0A= if(!window.devicePixelRatio) {=0A= this.getElementsByTagName("UL")[0].style.marginTop =3D "20px";=0A= this.getElementsByTagName("UL")[0].style.marginLeft =3D "0";=0A= }=0A= }=0A= this.className =3D"menuhover domArrowOver";=0A= if(document.all) = this.getElementsByTagName("iframe")[0].style.height=3Dthis.getElementsByT= agName("ul")[0].offsetHeight;=0A= }=0A= menu.childNodes[x].onmouseout=3Dfunction() {=0A= this.className =3D "domArrowOut";=0A= }=0A= }=0A= =0A= if(document.all) {=0A= var newIframe =3D document.createElement("iframe");=0A= newIframe.style.filter =3D = "progid:DXImageTransform.Microsoft.Alpha(style=3D0,opacity=3D0)";=0A= menu.childNodes[x].appendChild(newIframe);=0A= }=0A= =0A= } =0A= }=0A= // deletes the sub menus on the IEMAC as they have a = background bug, will still remain on NS6=0A= if ((navigator.userAgent.indexOf("Mac") !=3D -1) && = (navigator.userAgent.indexOf("MSIE") !=3D -1)){=0A= menu.childNodes[x].innerHTML =3D = menu.childNodes[x].innerHTML.split(""=0A= var menu =3D document.all["menu"].children[0];=0A= menu.style.marginBottom =3D "-3px";=0A= for (var x=3D1; x" + tmp + "";=0A= } else if (x=3D=3D5 || x=3D=3D6){ =0A= tmptable +=3D "" + tmp + = "";=0A= } else {=0A= tmptable +=3D "" + tmp + = "";=0A= }=0A= if (x =3D=3D (menu.children.length-1)){=0A= tmptable +=3D ""; =0A= }=0A= } else {=0A= var tmp =3D menu.children[x].innerHTML.split("" + tmp + = "";=0A= } else if (x=3D=3D2) {=0A= tmptable +=3D "" + tmp + = "";=0A= }=0A= }=0A= }=0A= menu.innerHTML =3D tmptable;=0A= }=0A= };=0A= =0A= var menuloadedflag =3D true;=0A= =0A= =0A= var time =3D new Date();=0A= //@@@DM It was anoying me this error =0A= var ordval=3D (time.getTime());=0A= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/js/journalhome.js //=0A= // Homepage links format:=0A= // homepagelinks[i][0] =3D location=0A= // homepagelinks[i][1] =3D currenthref=0A= // homepagelinks[i][2] =3D type: "e" =3D end of line, "s" =3D separator, = "" =3D normal=0A= //=0A= var writeLinksTraceOn =3D false;=0A= function writeJournalLinks(filename, oid)=0A= {=0A= var url =3D new String(document.location);=0A= var urlpathinfo =3D "";=0A= var pathinfomatch =3D false;=0A= =0A= // Find the pathinfo in the URL - need it later (probably)=0A= //=0A= // Both url and currenthref are expected to be of the form:=0A= // .....//[/]=0A= //=0A= =0A= urlindex =3D url.indexOf("jabout");=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("mrwhome");=0A= }=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("collectionhome");=0A= }=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("bookhome");=0A= }=0A= =0A= if (urlindex !=3D -1) // If found a known CGI name....=0A= {=0A= // We needs a pathinfo match.....=0A= pathinfomatch =3D true;=0A= =0A= // Find the end of the cgi-name=0A= urlindex =3D url.indexOf("/", urlindex + 1);=0A= =0A= // Look for the start of pathinfo=0A= urlindex =3D url.indexOf("/", urlindex + 1);=0A= =0A= if (urlindex !=3D -1)=0A= {=0A= urlindex1 =3D url.indexOf("?", urlindex + 1);=0A= =0A= if(urlindex1 !=3D -1){=0A= urlpathinfo =3D url.substring(urlindex + 1, urlindex1);=0A= writeLinksTrace("urlpathinfo: " + urlpathinfo); =0A= }else{ =0A= urlpathinfo =3D url.substring(urlindex + 1, url.length);=0A= writeLinksTrace("urlpathinfo: " + urlpathinfo);=0A= }=0A= }=0A= }=0A= =0A= var colnum =3D 0;=0A= =0A= for (var i =3D 0; i < homepagelinks.length; i++)=0A= {=0A= var location =3D homepagelinks[i][0];=0A= var currenthref =3D homepagelinks[i][1];=0A= var type =3D homepagelinks[i][2];=0A= =0A= writeLinksTrace(location + " : " + currenthref + " : " + type);=0A= =0A= if(type =3D=3D "x") // End of the list=0A= {=0A= break;=0A= }=0A= if(type =3D=3D "s")=0A= {=0A= document.writeln('
    ');=0A= colnum =3D 0;=0A= continue;=0A= }=0A= if (colnum > 0)=0A= {=0A= document.writeln(' | ');=0A= }=0A= =0A= var hrefindex;=0A= var urlindex;=0A= var greydisplay =3D false;=0A= =0A= // See what type of link we have=0A= =0A= // Cases here are for URLs with no /relevant/ pathinfo=0A= if (pathinfomatch !=3D true)=0A= {=0A= hrefindex =3D currenthref.indexOf("jhome");=0A= if (hrefindex !=3D -1)=0A= {=0A= urlindex =3D url.indexOf("jhome");=0A= if (urlindex !=3D -1)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= if (hrefindex =3D=3D -1) // Didn't find jhome, try jtoc=0A= {=0A= hrefindex =3D currenthref.indexOf("jtoc");=0A= if (hrefindex !=3D -1)=0A= {=0A= urlindex =3D url.indexOf("jtoc");=0A= if (urlindex !=3D -1)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= }=0A= // Add more non-pathinfo cases here...=0A= }=0A= =0A= // Cases under here are for cases with relevant pathinfo=0A= if (pathinfomatch =3D=3D true)=0A= {=0A= var hrefmatch =3D false;=0A= var hrefpathinfo =3D "";=0A= =0A= writeLinksTrace("pathinfo handler");=0A= =0A= // Find the pathinfo in the href=0A= =0A= hrefindex =3D currenthref.indexOf("jabout");=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("mrwhome");=0A= }=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("collectionhome");=0A= }=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("bookhome");=0A= }=0A= if (hrefindex !=3D -1)=0A= {=0A= // We needs a pathinfo match.....=0A= hrefmatch =3D true;=0A= =0A= // Find the end of the cgi-name=0A= hrefindex =3D currenthref.indexOf("/", hrefindex + 1);=0A= =0A= // Look for the start of pathinfo=0A= hrefindex =3D currenthref.indexOf("/", hrefindex + 1);=0A= =0A= if (hrefindex !=3D -1)=0A= {=0A= hrefpathinfo =3D currenthref.substring(hrefindex + 1, = currenthref.length);=0A= writeLinksTrace("hrefpathinfo: " + hrefpathinfo);=0A= }=0A= }=0A= =0A= // If we found a CGI matches in currenthref, and the=0A= // pathinfos match then grey this link=0A= if (hrefmatch =3D=3D true && urlpathinfo =3D=3D hrefpathinfo)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= =0A= // Time to write the link=0A= if (greydisplay =3D=3D true)=0A= {=0A= document.writeln('' + location + '');=0A= }=0A= else=0A= {=0A= document.writeln('' + = location + '');=0A= }=0A= =0A= // Defunct - separators now worked by from colnum=0A= // If end of line skip separator=0A= //if(type !=3D "e")=0A= //{=0A= // document.writeln(' | ');=0A= //}=0A= =0A= colnum++;=0A= }=0A= }=0A= =0A= function writeLinksTrace(message)=0A= {=0A= if (writeLinksTraceOn)=0A= {=0A= document.writeln(message);=0A= }=0A= }=0A= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/FILE?TPL=journal-article.html-navbar&mode=html Navbar = =
    3D""=20
    Home / Medical, Veterinary and Health Sciences / = Oncology and Radiotherapy=20
    3D"Utility
    3D""=20
    ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/txt.jump-to.gif R0lGODlhOQAQAKIHAP/x3P/WmP+8V/+yP//lv//Mf/+ZAP///yH5BAEAAAcALAAAAAA5ABAAAAPM eLrc/jAyIE8xihiiTMkGpgiecoUCt5xhyJHGQEEXqJaHZszhZ3mnWa5wIgIChoBGEKnlNh2fZhA4 AGI+p6baGAwWXpOIIBTboqACs+DNjqHdb4d5QAKuvtX7Jt1gBmxuXjFlCmFoTxyFP2cHOBqOGgCA YgMCAYsHh450GiorVVpwj38Df24Vm4dODISmCldMSCqQSEyUjBKbF2QxJjNIPQswBnRPVkmaqLpy VqYhFHgLAGQN1JkV2Q0E1bDa3+Dh4uPk5ebn6Onq698JADs= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-BOTTOM: 0px; BACKGROUND-COLOR: #fff; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; COLOR: #333; PADDING-TOP: 0px } H1 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H2 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H3 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H4 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H5 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H6 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } LI { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } DT { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } DD { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } .txt { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } FIELDSET { BORDER-BOTTOM-STYLE: none !important; PADDING-BOTTOM: 0px !important; = BORDER-RIGHT-STYLE: none !important; MARGIN: 0px; PADDING-LEFT: 0px = !important; PADDING-RIGHT: 0px !important; BORDER-TOP-STYLE: none = !important; BORDER-LEFT-STYLE: none !important; PADDING-TOP: 0px = !important } LEGEND { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-BOTTOM: 0px; MARGIN: 0.25em 0px 0.25em 1.25em; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } DL { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DT { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DD { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment LI { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment LI { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment TD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment DD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment DD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .HomepageFragment TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment H1 { COLOR: #f90; FONT-SIZE: 20px; FONT-WEIGHT: bold } .homepageFragment H2 { COLOR: #f90; FONT-SIZE: 18px; FONT-WEIGHT: bold } .homepageFragment H3 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H4 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H5 { COLOR: #f90; FONT-SIZE: 14px; FONT-WEIGHT: bold } .homepageFragment H6 { COLOR: #f90; FONT-SIZE: 12px; FONT-WEIGHT: bold } .HomepageFragment H1 { COLOR: #f90; FONT-SIZE: 20px; FONT-WEIGHT: bold } .HomepageFragment H2 { COLOR: #f90; FONT-SIZE: 18px; FONT-WEIGHT: bold } .HomepageFragment H3 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .HomepageFragment H4 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .HomepageFragment H5 { COLOR: #f90; FONT-SIZE: 14px; FONT-WEIGHT: bold } .HomepageFragment H6 { COLOR: #f90; FONT-SIZE: 12px; FONT-WEIGHT: bold } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, sans-serif; = FONT-SIZE: 11px } .HomepageFragment ADDRESS { FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, sans-serif; = FONT-SIZE: 11px } TABLE.menuIEFOUR { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; BACKGROUND-COLOR: #13709d; MARGIN: 0px; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: left top } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .menuIEFOURSIDE { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .menuIEFOURDOWN { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } TABLE.menuIEFOUR TD { PADDING-BOTTOM: 0.2em; FONT-SIZE: 70%; FONT-WEIGHT: bold; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; COLOR: white; FONT-WEIGHT: normal; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { TEXT-TRANSFORM: uppercase; FONT-STYLE: normal; COLOR: #6089b2; = FONT-SIZE: 0.7em; FONT-WEIGHT: bold } H3.navigationHeader EM { FONT-STYLE: normal; COLOR: #ff9b06; FONT-SIZE: 1.1em } .homepageFragment .mostAccessed { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-BOTTOM: 0px; MARGIN: 0.25em; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif; COLOR: #ff9900; = FONT-SIZE: 11px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .HomepageFragment .mostAccessed LI { PADDING-BOTTOM: 0px; MARGIN: 0.25em; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif; COLOR: #ff9900; = FONT-SIZE: 11px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI DIV { COLOR: #000000; FONT-SIZE: 100%; FONT-WEIGHT: normal } .HomepageFragment .mostAccessed LI DIV { COLOR: #000000; FONT-SIZE: 100%; FONT-WEIGHT: normal } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } DIV.banner TABLE TD A { DISPLAY: block } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-COLOR: #13709d; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-POSITION: left top } UL.menuDOM LI { BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0.2em; DISPLAY: block; FLOAT: = left; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { PADDING-BOTTOM: 0px; DISPLAY: block; BACKGROUND: white; COLOR: white; = FONT-SIZE: 100%; FONT-WEIGHT: bold; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuDOM LI UL { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuIEMAC { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuDOM A { PADDING-BOTTOM: 0.1em; PADDING-LEFT: 0.1em; PADDING-RIGHT: 0.1em; = DISPLAY: block; COLOR: #90d7ff; FONT-WEIGHT: bold; PADDING-TOP: 0.1em } .hideNSFOUR LI A { WHITE-SPACE: normal } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } LI.nosaved EM { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1em; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: left center } UL.menuIEMAC A.menuSideArrow { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1em; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: left center } UL.menuDOM LI UL { POSITION: absolute; TOP: 2.25em; LEFT: -999em } UL.menuDOM LI.menuhover UL { Z-INDEX: 999; BORDER-BOTTOM: #90d7ff 1px solid; BORDER-LEFT: #90d7ff = 1px solid; WIDTH: 200px; DISPLAY: block; BACKGROUND: white; MARGIN-LEFT: = -1.25em; BORDER-TOP: #90d7ff 1px solid; TOP: auto; BORDER-RIGHT: #90d7ff = 1px solid; LEFT: auto; voice-family: inherit } UL.menuDOM LI IFRAME { POSITION: absolute; TOP: 2.25em; LEFT: -999em } UL.menuDOM LI.menuhover IFRAME { Z-INDEX: 998; WIDTH: 202px; MARGIN-LEFT: -1.25em; TOP: auto; LEFT: auto } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-BOTTOM: 5px; MARGIN-TOP: 0px !important; PADDING-LEFT: 5px; = WIDTH: 190px; PADDING-RIGHT: 5px; DISPLAY: block; BACKGROUND: #ff9900; = COLOR: white !important; FONT-WEIGHT: bold; PADDING-TOP: 5px; = voice-family: inherit } LI.nosaved EM { COLOR: black !important; FONT-WEIGHT: normal !important; = TEXT-DECORATION: none !important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none !important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif) = !important; MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1.25em; = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .domArrowOut { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) = !important; MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1.25em; = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } UL.menuIEMAC A { PADDING-BOTTOM: 0.1em; PADDING-LEFT: 0.1em; PADDING-RIGHT: 0.1em; = COLOR: #90d7ff; FONT-WEIGHT: bold; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { PADDING-BOTTOM: 3px; DISPLAY: inline } UL.menuIEMAC LI UL { POSITION: absolute; LEFT: -999em } UL.menuIEMAC { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif) = !important; PADDING-BOTTOM: 0.1em; BACKGROUND-COLOR: #13709d; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: left top } #user { BACKGROUND-IMAGE: none; PADDING-LEFT: 5em; PADDING-RIGHT: 2em; COLOR: = white } #mycart { BACKGROUND-IMAGE: none; PADDING-LEFT: 5em; COLOR: white } #menu { BORDER-BOTTOM: transparent 1px solid; BORDER-LEFT: transparent 1px = solid; BORDER-TOP: transparent 1px solid; BORDER-RIGHT: transparent 1px = solid } .hideNSFOUR LI A { WHITE-SPACE: normal } .hideNSFOUR LI { WHITE-SPACE: normal } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.standards.css @import url( /freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { MARGIN: 0.25em 0em; PADDING-LEFT: 1em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: url(/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-IMAGE: url(/images/bg.basic.gif); BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 100% 100% } #searchBox { BACKGROUND-IMAGE: url(/images/bg.search.gif); BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 0% 100% } #citationBox { BACKGROUND-IMAGE: url(/images/bg.citation-finder.gif); = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: 0% 0% } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-BOTTOM: 2px; TEXT-INDENT: -16px; MARGIN: 0px; PADDING-LEFT: = 22px; PADDING-RIGHT: 3px; COLOR: #666; FONT-WEIGHT: bold; PADDING-TOP: = 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-BOTTOM: 2px; TEXT-INDENT: -16px; MARGIN: 0px; PADDING-LEFT: = 22px; PADDING-RIGHT: 3px; COLOR: #666; FONT-WEIGHT: bold; PADDING-TOP: = 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .dataTable TH { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { TEXT-ALIGN: right; MARGIN: 0px; FONT-WEIGHT: bold } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { BORDER-BOTTOM: #ccc 2px solid; COLOR: #f90 } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { TEXT-ALIGN: left; FONT-WEIGHT: normal } #contentFrame .mainCol #footer { MARGIN: 10px 10px 0px; BORDER-TOP: #ccc 2px solid; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { MARGIN-BOTTOM: 0px; COLOR: #666; FONT-SIZE: 70% } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { BORDER-LEFT: #ccc 1px solid; PADDING-BOTTOM: 7px; MARGIN: 0px 0px 15px; = PADDING-LEFT: 10px; PADDING-RIGHT: 10px; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = MARGIN-BOTTOM: 0px; BORDER-LEFT-STYLE: none; PADDING-TOP: 10px } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { BORDER-BOTTOM: #cce5ff 1px solid; MARGIN-TOP: 1px } #contentFrame .sideCol #citationBox .item { PADDING-BOTTOM: 10px; MARGIN: 0px 10px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { MARGIN-BOTTOM: 0px; COLOR: #666; FONT-SIZE: 70% } #contentFrame .sideCol #relatedProducts UL { PADDING-BOTTOM: 8px; MARGIN-TOP: 0px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { TEXT-ALIGN: right; PADDING-RIGHT: 0.5em } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { COLOR: #9cf; FONT-WEIGHT: bold; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-IMAGE: url(/images/fill.personal-nav.gif); WIDTH: 100%; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: right top } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = WHITE-SPACE: nowrap; PADDING-TOP: 0px } #personalnavSpecial { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-WEIGHT: bold; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-BOTTOM: #069 2px solid; BORDER-LEFT: #069 2px solid; = PADDING-BOTTOM: 2px; PADDING-LEFT: 2px; PADDING-RIGHT: 2px; FONT-FAMILY: = arial; FONT-SIZE: 11pt; BORDER-TOP: #069 2px solid; BORDER-RIGHT: #069 = 2px solid; PADDING-TOP: 2px } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { TEXT-ALIGN: center; LINE-HEIGHT: 140% } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: url(/images/bg.logo.home.jpg); BACKGROUND-COLOR: = #001941; BACKGROUND-REPEAT: no-repeat } #logoCell { BACKGROUND-IMAGE: url(/images/bg.logo.jpg); BACKGROUND-REPEAT: = no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; COLOR: #666; FONT-WEIGHT: bold } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-BOTTOM: red 1px solid; BORDER-LEFT: red 1px solid; = BACKGROUND-COLOR: #fcc; BORDER-TOP: red 1px solid; BORDER-RIGHT: red 1px = solid } #browserWarning { BORDER-BOTTOM: #c00 1px solid; BORDER-LEFT: #c00 1px solid; = PADDING-BOTTOM: 0.3em; BACKGROUND-COLOR: #fef; MARGIN: 5px 28px; = PADDING-LEFT: 0.3em; PADDING-RIGHT: 0.3em; FONT-FAMILY: arial; COLOR: = #300; FONT-SIZE: 100%; BORDER-TOP: #c00 1px solid; BORDER-RIGHT: #c00 = 1px solid; PADDING-TOP: 0.3em } .invisible { POSITION: absolute; WIDTH: 0px; HEIGHT: 0px; OVERFLOW: hidden } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { MARGIN: 10px; FLOAT: left } .linkPrint { MARGIN: 10px 20px 0px 0px; FLOAT: right } .linkTop { TEXT-ALIGN: right; CLEAR: both } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { COLOR: #c00; FONT-WEIGHT: bold } #errorList LI { LIST-STYLE-TYPE: none; COLOR: #c00 !important; FONT-WEIGHT: bold } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 0px !important } #contentFrame #intro .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { BORDER-LEFT: #ccc 1px solid; PADDING-BOTTOM: 6px; MARGIN: 10px 0px; = PADDING-LEFT: 8px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { COLOR: #369; FONT-SIZE: 80% } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { TEXT-INDENT: -2em; MARGIN: 0px; PADDING-LEFT: 2em; COLOR: #666 } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { LINE-HEIGHT: 150%; MARGIN-TOP: 8px; COLOR: #000; BORDER-TOP: #ccc 1px = solid; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalReferences .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalArticleMain .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { TEXT-ALIGN: center; MARGIN: 0px } #contentFrame #content .issueNav SPAN { COLOR: #f90; FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { BORDER-BOTTOM: #ccc 1px solid; PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px = 0.5em; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px = solid; PADDING-TOP: 0.5em } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-BOTTOM: 10px; PADDING-LEFT: 6px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none !important } .journalArticleMain #intro .item { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 0px !important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px !important; PADDING-TOP: 10px !important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px !important } .journalArticleMain #searchBox { WIDTH: 150px; BORDER-RIGHT: #99c2d6 1px solid } .journalArticleMain #intro #searchBox .item { PADDING-BOTTOM: 10px !important; PADDING-LEFT: 10px !important; = PADDING-RIGHT: 10px !important; PADDING-TOP: 10px !important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px !important; PADDING-TOP: 0px !important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = BACKGROUND: #565565; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { COLOR: #369; FONT-SIZE: 80% } #contentFrame #content .prerendered { FONT-FAMILY: arial, helvetica, sans-serif; COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered TABLE { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { BACKGROUND-COLOR: #fff; COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered TH { BACKGROUND-COLOR: #fff; COLOR: #333; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { COLOR: #333; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT A { COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered FONT[size=3D'+1'] { COLOR: #666; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-SIZE: 14px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT[size=3D'4'] A { COLOR: #090; FONT-SIZE: 14px } #contentFrame #content .prerendered P { COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-FAMILY: arial, helvetica, sans-serif; COLOR: #333; FONT-SIZE: 12px } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-SIZE: 140%; FONT-WEIGHT: bold } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { TEXT-TRANSFORM: uppercase; DISPLAY: block; COLOR: #f90; FONT-SIZE: = 110%; FONT-WEIGHT: bold } .prerendered .firstLevelHeading { DISPLAY: block; COLOR: #369; FONT-SIZE: 11pt; FONT-WEIGHT: bold } .prerendered .secondLevelHeading { DISPLAY: block; COLOR: #369; FONT-SIZE: 11pt } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { COLOR: #369; FONT-SIZE: 10pt } .prerendered .referenceNum { COLOR: #369; FONT-SIZE: 10pt } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/bpg.css .prerendered .invisible-anchor { DISPLAY: none } .prerendered A { COLOR: #336699; TEXT-DECORATION: none } .prerendered .body-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .appendix-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .toc-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .article { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .doi-title { MARGIN-BOTTOM: 6pt } .prerendered .articletext { TEXT-TRANSFORM: uppercase; MARGIN-TOP: 12pt; MARGIN-BOTTOM: 0.4em; = COLOR: #333333; FONT-SIZE: 12px; FONT-WEIGHT: bold } .prerendered P.para { MARGIN-TOP: 0em } .prerendered .titlegroup { MARGIN-BOTTOM: 12pt } .prerendered .title-document { DISPLAY: block; FONT-SIZE: 140%; FONT-WEIGHT: bold } .prerendered .title-surtitle { COLOR: #666666; FONT-SIZE: 100%; FONT-WEIGHT: bold } .prerendered .title-subtitle { COLOR: #666666; FONT-SIZE: 100%; FONT-WEIGHT: bold } .prerendered .correspondence-label { =09 } .prerendered P.reference-list-para { PADDING-BOTTOM: 0px; LINE-HEIGHT: 150%; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; VERTICAL-ALIGN: middle; PADDING-TOP: 0px } .prerendered .clear-both { LINE-HEIGHT: 0px; HEIGHT: 0px; CLEAR: both } .prerendered UL.references-list { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.references-list { CLEAR: both } .prerendered UL.references-list LI { CLEAR: both } .prerendered UL.references-list SPAN.reference-list-label { WIDTH: 3%; FLOAT: left } .prerendered UL.references-list P.reference-list-para { MARGIN: 0px; WIDTH: 97%; FLOAT: left } .prerendered UL.toc-list LI { FONT-SIZE: 100% } .prerendered UL.references-list LI { FONT-SIZE: 100% } .prerendered UL.listlevel1 LI { LINE-HEIGHT: 120%; FONT-SIZE: 100% } .prerendered UL.listlevel2 LI { FONT-SIZE: 100% } .prerendered UL.listlevel3 LI { FONT-SIZE: 100% } .prerendered UL.listlevel4 LI { FONT-SIZE: 100% } .prerendered UL.listlevel5 LI { FONT-SIZE: 100% } .prerendered UL.listlevel6 LI { FONT-SIZE: 100% } .prerendered UL LI { FONT-SIZE: 100% } .prerendered P.list-para { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 10px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel1 { MARGIN-BOTTOM: 12pt } .prerendered UL.listlevel1 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel2 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel3 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel4 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel5 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel6 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel1 { CLEAR: both } .prerendered UL.listlevel2 { CLEAR: both } .prerendered UL.listlevel3 { CLEAR: both } .prerendered UL.listlevel4 { CLEAR: both } .prerendered UL.listlevel5 { CLEAR: both } .prerendered UL.listlevel6 { CLEAR: both } .prerendered UL.listlevel1 LI { CLEAR: both } .prerendered UL.listlevel2 LI { CLEAR: both } .prerendered UL.listlevel3 LI { CLEAR: both } .prerendered UL.listlevel4 LI { CLEAR: both } .prerendered UL.listlevel5 LI { CLEAR: both } .prerendered UL.listlevel6 LI { CLEAR: both } .prerendered UL.listlevel1 SPAN.list-label { LINE-HEIGHT: 150%; WIDTH: 5%; FLOAT: left } .prerendered UL.listlevel1 P.list-para { LINE-HEIGHT: 150%; MARGIN: 0px; WIDTH: 95%; FLOAT: left } .prerendered UL.listlevel2 { MARGIN: 0px 0px 10px 5%; CLEAR: both } .prerendered UL.listlevel2 { MARGIN: 0px 0px 10px 5%; CLEAR: both } .prerendered UL.listlevel3 { MARGIN: 0px 0px 20px 5% } .prerendered UL.listlevel3 SPAN.list-label { WIDTH: 5%; FLOAT: left } .prerendered UL.listlevel3 P.list-para { WIDTH: 95%; FLOAT: left } .prerendered UL.listlevel4 { MARGIN: 0px 0px 30px 5%; CLEAR: both } .prerendered UL.listlevel5 { MARGIN: 0px 0px 40px 5% } .prerendered UL.listlevel6 { MARGIN: 0px 0px 50px 5% } .prerendered UL.listlevel2 SPAN.list-label { WIDTH: 5%; FLOAT: left } .prerendered UL.listlevel2 P.list-para { WIDTH: 95%; FLOAT: left } .prerendered .table { TEXT-ALIGN: center; MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt } .prerendered .table-title { FONT-WEIGHT: bold } .prerendered H1 { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 0.4em; COLOR: #336699; FONT-SIZE: = 1.1em; FONT-WEIGHT: bold } .prerendered H1 .abstract-title { MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; FONT-SIZE: 1.1em; FONT-WEIGHT: = bold } .prerendered H1 .abstract-title-with-preceding-heading { MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; FONT-SIZE: 1.1em; FONT-WEIGHT: = bold } .prerendered H2 { MARGIN-TOP: 0.4em; MARGIN-BOTTOM: 0em; COLOR: #336699; FONT-SIZE: 1em; = FONT-WEIGHT: bold } .prerendered H3 { FONT-STYLE: italic; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; COLOR: = #336699; FONT-SIZE: 1em; FONT-WEIGHT: bold } .prerendered .h3-inline { FONT-STYLE: italic; COLOR: #336699; FONT-SIZE: 1em; FONT-WEIGHT: bold } .prerendered H4 { FONT-STYLE: italic; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; COLOR: = #336699; FONT-SIZE: 1em } .prerendered .h4-inline { FONT-STYLE: italic; COLOR: #336699; FONT-SIZE: 1em } .prerendered H5 { MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; FONT-SIZE: 1em } .prerendered .h5-inline { FONT-STYLE: normal; DISPLAY: inline; FONT-SIZE: 1em; FONT-WEIGHT: bold } .prerendered .heading5-inline { DISPLAY: block; COLOR: #666666; FONT-SIZE: 100%; FONT-WEIGHT: bold } .prerendered .correspondence-address { MARGIN-TOP: 8pt; DISPLAY: block } .prerendered .bpg40copyright { MARGIN-TOP: 16pt; DISPLAY: none } .prerendered .doi-block { MARGIN-TOP: 16pt; DISPLAY: block; MARGIN-BOTTOM: 8pt } .prerendered .doi-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .keywords-block { MARGIN-TOP: 16pt; DISPLAY: block } .prerendered .keyword-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .abstract-content { DISPLAY: block; CLEAR: left; PADDING-TOP: 1pt } .prerendered .b { FONT-WEIGHT: bold } .prerendered .highlight { FONT-WEIGHT: bold } .prerendered .i { FONT-STYLE: italic } .prerendered .overline { TEXT-DECORATION: overline } .prerendered .slanted { FONT-STYLE: oblique } .prerendered .smallcapitals { FONT-VARIANT: small-caps } .prerendered .strike { TEXT-DECORATION: line-through } .prerendered .tt { FONT-FAMILY: "Courier","Lucida Sans Typewriter","Courier = New","LucidaTypewriter", fixed } .prerendered .u { TEXT-DECORATION: underline } .prerendered .uu { TEXT-DECORATION: underline } .prerendered .openface { =09 } .prerendered .roman { FONT-STYLE: normal } .prerendered .sansserif { FONT-FAMILY: sans-serif } .prerendered .scriptface { =09 } .prerendered .questiongroup { =09 } .prerendered .question { =09 } .prerendered .answer { =09 } .prerendered .hint { =09 } .prerendered .feedback { =09 } .prerendered .toc-content { =09 } .prerendered .toc-journal-title { FONT-WEIGHT: bold } .prerendered .toc-issn { =09 } .prerendered .toc-vol-issue { MARGIN-TOP: 12pt } .prerendered .toc-pages { =09 } .prerendered .toc-sections { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt } .prerendered .toc-tables { =09 } .prerendered .toc-figures { =09 } .prerendered .toc-abstract-only { =09 } .prerendered .block_formula { POSITION: relative; MARGIN: 1em 0pt; WIDTH: 98%; DISPLAY: block; = WHITE-SPACE: nowrap } .prerendered .block_formula .formula_caption { POSITION: absolute; TOP: 33%; RIGHT: 0px } .prerendered .block_formula .formula_display { =09 } .prerendered .inline_formula IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .reference-document-title { =09 } .prerendered .reference-subtitle-title { =09 } .prerendered .reference-journal-title { FONT-STYLE: italic } .prerendered .reference-book-title { FONT-STYLE: italic } .prerendered .reference-conference-title { =09 } .prerendered .reference-other-title { =09 } .prerendered .reference-date { =09 } .prerendered .reference-volume { FONT-WEIGHT: bold } .prerendered .reference-page { =09 } .prerendered .reference-publisher { =09 } .prerendered .reference-edition { =09 } .prerendered .reference-issue { =09 } .prerendered .reference-thesis { =09 } .prerendered .reference-inpress { =09 } .prerendered .reference-supplement { =09 } .prerendered .reference-miscellaneoustext { =09 } .prerendered .figure-legend { FONT-SIZE: 0.8em; FONT-WEIGHT: bold } .prerendered P.legend-para { MARGIN-TOP: 0em; MARGIN-BOTTOM: 0em; MARGIN-LEFT: 1.6em } .prerendered .figure { MARGIN-BOTTOM: 6pt } .prerendered .image-links { MARGIN-LEFT: 2em; FONT-SIZE: 0.8em } .prerendered .table-legend { =09 } .prerendered .toc-content { =09 } .prerendered TABLE.data-table TH { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } .prerendered TABLE.data-table TD { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } .prerendered .bp_abstractinfo { DISPLAY: none } .prerendered .header-footnotes { MARGIN-TOP: 6pt } .prerendered .inline_image IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .fixed-image { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered .fixed-legend { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered A.externallink { COLOR: #336699 } .prerendered .subsection-box { BACKGROUND-COLOR: #f9e3df } .prerendered .tbltl { MARGIN-TOP: 0.5em } .prerendered .bookdetails { MARGIN-TOP: 8pt; MARGIN-BOTTOM: 8pt } .prerendered .references .reference-content { DISPLAY: inline } .prerendered .para .reference-content { DISPLAY: inline } .prerendered .reference-content { DISPLAY: block } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/toc.html,journal-article.html-sidebar Article Table of = Contents = =

    3D"Jump

    International = Journal of=20 Cancer
    ISSN: 1097-0215 = (Online)
    ISSN:=20 0020-7136 (Print)

    Forthcoming Articles
    Pages: NA
    • Top of page
    • Abstract
    • Material and methods
    • Results
    • Discussion
    • Acknowledgements
    • References
    Tables: I, II
    List=20 of Images
    Abstract=20 Only

    ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/jpeg Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/homepages/29331/bannerforeground.jpg /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAAUAAA/+4AJkFkb2JlAGTAAAAAAQMA FQQDBgoNAAAPcQAAIcIAADOvAABMCf/bAIQAAgICAgICAgICAgMCAgIDBAMCAgMEBQQEBAQEBQYF BQUFBQUGBgcHCAcHBgkJCgoJCQwMDAwMDAwMDAwMDAwMDAEDAwMFBAUJBgYJDQsJCw0PDg4ODg8P DAwMDAwPDwwMDAwMDA8MDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwM/8IAEQgAOgICAwERAAIR AQMRAf/EAQkAAAICAwEBAAAAAAAAAAAAAAAGBQcDBAgBAgEBAAIDAQEBAAAAAAAAAAAAAAMEAQIF BgcIEAABAwMDAQcDBQADAQAAAAACAQMEABEFEBITBiAhMTIzFDUwIhVAUEE0FkIjJCURAAIBAwID AwUIDwYGAwAAAAECAwARBBIFITETQVEiYXEyQhQQgZGhsVIjcyDB4WJykrLC0jNjkzR0NdGCQyQV BjBAUPCiU4QlFhIAAQMBBQQJBAIDAQAAAAAAAQARAiEQMUESAyBRcTIwUPBhgZGhsSJAwdETYPHh QlJiEwEAAgIBAwMEAgMBAQAAAAABABEhMUFRYXEQgZHwobHBIOEw0fFAUP/aAAwDAQACEQMRAAAB gPOfdwD1jYzpr43GfAHafka2JFKHpgAAAAAAAAAAAAAAAAAAAAAAAAAAAe4rzsPhmuPhKWuezfZ8 LaZ06lmGil3J4c1urpbacWeV+/XHc8tFa2F2O+2S8zYzpUdT0zjNy1+O61S86N1nnt6ahF02qXnf TE/JSRIOzM71F2K9blzzNLUvWN83L38wxutiI0suM3Lq+t6F8n4yjD07Es8PT1lXY709JSrGr6EA AAAAAAAAAAAPWrdD80dHL931T8bdZ+o46JWuKUdpRjkn9NLYu8zUtV+QvMffb8v+LVIulV1X0W/t DatrzctvWpKl62c3qS+9WM1sMG9JOi6jrNydXEkZpYYJKWDG/wAs2FY4dSVPTM0vPw43SYes2y83 NnRZi6DRLzl2O8wyUsjVbjvtsvMqKp6cAAAAAAAAAAAAJDHnbCj8Az741N9ZnTNsek5VRVulBx2F rXK1HpZlvl2ZZg5L8597vu/4xUi6NX1fRXbd8lAaXHmfj88c73IO0/I1sSJMd75YwZjktLQB6aO0 HpuazgAAGhvXy42+GN3WcAAAAADPnTe2hkdoJTavK71pTatKb15DaDczF9sAAAjU+bkp89gm0Wo9 vnZ0V6Pl88UuogNlrTOHWNjlj6t6XJ488z99vy/4tUi6VXVfRdO9P57zZzffXNd8pR9H17FJRlN6 2tiSodoNnWSDlos0PU2cSa2Y8+JF6Xm6m0NhVPRrs3N2NZNrEsdvXmo7tfWfOz0fQ8YkNbP3jP02 GPDS2gZoeoAau0WTasx7QtG9SOscN+3rSklC25KkDJQfNq9OZ16AIklhTKm59hV492L3MWML7PTn p+Rzjzu0nJa911yRqxnp0xe5nXXnfvds2/NSW1enKfqekel4PmbmfQG2bmYsbRuthgko62JKNl5r jX7Vf2vO/OcSWlnJjdfl52bG8ppbeq3eT5+Nr7Ram0UpHae63frq35v6Z2tZdDaCBl509F0PjONn WWM3qWDV9GnWOKEzHd1JKUjvWtuO3DWOHPyUYybmsu9Z12rt+YpvOtckcTQ1jjrnlLy/Vcd9WGTS soJs3quAjRWd6p26/wBWSOGvr3F+NlxcL72DZLzZTesnQ9XQ1mAAdp+RrYkQtLWbG+HOm1rL9M4M 6en0z9Yz9ttLaDYxJ4Z8SBpbQBkxtkxtgzH9tvTLjfxjLjfX2jy428Mu0E1vXnt6bPJSmpOewyUW KSiwyVNvavJZ1xGqapJG+UhVl2eZtV1OVe02pz2fmmIt6v16So3Zm9xkOOBDzjoXh/oAAAAAAdp+ RrYkUoemAAAAAAAAAAAAAAAAAAAeM+Hh4z4B4AAAAAqzeXvyh4dRh2pb2vl57Z1PNJzLVtbWatXV 8KGH/9oACAEBAAEFAuw4y6yvY6c+dz3zX7Y1CvTiRmo/MYuD5N6IjkwG0TJvEoThJXDrfpjul4mV HLYGHiUxmRDF0fVsmUEWRGhQfuMjwxRW3YyAGBacY6iz3zTGNixMIT0NyNksexhWZePjLiHsJByM FGm5EXLMQcPIIoCvOYTFLnYrDbsrKwImJzUONAkYXHJjp+QyQx4uVxcLHTeoJCgr+FxDOSjNvRGo uZj4vEzMfDgP4kmYzr+YgBjH/wBJ41CjDWNFhZeTB5x9Yi7w9KVNJHnpClTkp0FZzqm46+zt36dA /wBzrH5+mY0iQfVgezTCQ2MPipEh6W/hX2I+SwTpP9R575pqfFm4Mo0duPlZsbOMSp8dvCuTDgZD K5iI9Iy70TJTsu7jX5svOY2VkARmEzkpkTJ4XHSIjfT+NlJByGUaxsif09OjMZr2sS8TJDjcjmW4 R5HqeVEmu4mXGjYUxYkutZX2+I/SRh3ONiLbcFtCYy5qs5JDMer7Y8xxDkukKA5Y0dRW6gS/c1bT oH+71j8/XRKSX8lm5snJZvrp1Gg06c+dz3zTrzTKNPsPoM2GZdgJMdxx6RHjJ2nZUVklfZRtqTHf +mg3oY+6hx6FQYcSoOngKg6VAqHo1sqHoZpaToFpa/wDVf4Bqv8AANV/gGq/wDVZLBjhT4SUIcuL Ex02Skt4ZfK+YqsSQTlNQp/u5QyXJgLOrHvut5b7dOgU/wDZ1j8/XSYJjcCDxg/1oqSlqXCWHG6c +dz3zWff4MTDkY+LFwtpMyRk4cZDmxm3msnBeFicxIfxVn38k+zPJVRE/L47kk5CNEQpbAyVysAQ ZdB9rMmyeRm5SG1EwzIw8SORim+zPjvyGp0V6O3PiONpPiki5eALOrx8TMBx16LGV4kC9sHljnPQ XZrk3Mz5WNhNpWZyUvH1NfWLCa6oy7OJphyWb9Z3JphsPnQddZ527O8bpYZAF91tphQT/rnsrHkc jxUTjoSXHrl1DPGM1+ay2mP6pTFhmpTmQxTTTj7vVEhrFYSomXdjxffRWlmTH5znTnzue+azBC/k J0hIsNh1cb04ZMrOVoZeadltHlGJnBhiNoIzMpuTnJHBwNzobrUlxp/KY82pEjCNk61UIklZ/qM0 KPkH2imY5wZk73ajjXQjriZTyyH5qx4mNfZbYqc+ceG4ftCitEMrMKRRTL2tAzsbdeSLFykVyA0L xSKgvnkJENZ7JY/hXqrrt8g6bkdOQbYaLHkYCB7JrAypX42OxjoZRM3C95DdUo5R21hY95W8Kzvc kmXWk4qh5bKzpT8bmbciO75Ttqfxl5n+awesbKKEOJlYGMKTJfmP9jpz53PfNFEiETjDLqe0i7ON tDQAFeBjcrDCtuMtO0LbYkQiVLEiq5wtcqMsiCIgoqISBFitkcWK4SMMIYNNtikWMjZx2HDdYZfQ gA642+RURURllA2AhkAHSMsK203HF3bFeFk4wj/814B/Em+pYd9xh/EtOPlgJdLMxJNOScK7HcLp 95pW+mViq/hFe/JY6s/BxztR50CZKys1/IS+VxXeVDkQZKx0zMZ2HT8t90no7eMxb8lfb8o/S6c+ dz3zX7Yn9zM+sfka9Vz+i58Pg/7XV39aT5K//9oACAECAAEFAvot+Y/N+2KvYVaVavQn2Ba3UQIN CVq5b0i2StlqtQeY/NtsPdRDtpR7tiKlEiDXdWxNyUSbSRE2jZVLuUURSWgG+hogqKJajG36bx7J LrehXVjxe81Wp3uoE2oq3oPEPMfm3XG1Eu6lLuvZSOi71O11NFXwoluIr9orZStdtfutSFZTtdxb 0K/bW7u/SL4UiUupdgdWPF7zUz4mtyf1b8x+a1WravZtSJft2WrVb6lq21srjrirhrgrgrgrgrgr grgp4NqVeybtFq+t6Re/Rjxe81Ndw0936Klqb8x+ZtPuVFVXO5EBVrbWxaUbUfdQpbTYtIN6tWxa XuoPAQW7i3LatKNbVratbVrYvYSl8dFTRPoyE+3RNSSkpdATv0F21Gt0p1do0hVelW9N+Y/MHgKX VU3H/HgNvtUbl/KpYUratJ4F3U5oXcLVCncXclu//kiWoe9UWhS6+NL4B4p36JQ/TVL0SbV/jw1J NF1vqhdyEiUq37LfmPzXWr1ddb1er63Wr1fW61davpdavV7di+t6vSLV6vV6ulbkrclbkrclbkrc lbkrclOgJ0qWXdfQdHArxpA2/Ub8x+b9s/g/Gk1Ci1//2gAIAQMAAQUC7Akhdmf6EP0f2t10W0fn m52ESrVtog7D+RNmo0w36kMc1JjBBXAJw/Cklb1E71MJCjw/RN8jfQTQmHlkK2+XKMs2j3KJRjN8 U32SW7wOGqDGeJ9l0zF5/kbbYUjakOuNxw8JclWiUSUopuvg+64LqESDFeV5P0irapUhXi7ADVqt SpRa5ryYv0KJwRrGrvqW6r7oAgJKBSbmDtjQ/RJkm30MlKM0Ucm2SV4WuRuPFIRjCTQRhcEG4bgN rdxWGjZefA1kPt8jccnBbnMkTPIVOMcrcVTRvHtm2klsjeTcCFH3PfpMk5tb0TRKDw1LXNeTF+hW W2i3EaFljDjfWf6EP0SNBoXBKkfBeyjgqpuCHbJ0BreNhcE/p3pTpXqWVSzqXIrS5Va/MLX5pa/N LX5pa/NLX5pa/NLT0z3K1bvtoNWpEtS1atuua8mL9CskvK+ooqYn7NG3eQp/oQ/RyB7WGXGmwhfe 45KAKV8EIJTZUD4mUT7ykmL1Kte8au7IFuleFC923YDQ0mkKuvywEIQcTCSQUgkCZA+BCMgFRJAU sxvbqZbRaJSDvoqB3dSqt3FtRUVL2m/HRdRWlpKKj8u3R7Hc1RG0adIkFMcCvPU5GQi4SWmmkbSf 6EP0Zi73X3OMGz4IiqPJt5JBOorzb2yOqogA6hyXNu0X2yRwkJ6OSGUEdyUwvJJyRXGQ4nJGLkc5 v+ohHgdPeTyi20YIFPmoARcdNDY5veBrspRsji7UfHbRLSrelpaXtot9PHTdTJ2WrUa2q9X1OPc3 I5vU22Ladif6EP0VZBaIBKuELbUuiIlcY1xjYgQqQURVS9cIX2JdAFErxpGgSlaBa4xugoNcQWVs VUwE6UUWtqXrYNrJdRRaVtLKCXML0oLRNLRMlRMnSsHXA5XA5XA5XA5XA5XA5XA5QtuDVlRES2i6 NO0RWo3N31J/oQ/R/bJNJournY//2gAIAQICBj8C/gV6vsqnsrsPa6pY1jWk2tsnqhlm2WtZUThO qLutNjp7aWFVTHqduv3sB2wNkBPtnqi5PY1jbJNpNoCJtawJrAnToIBOjYTaU6CPTN0rKnWlcNlx /Bv/2gAIAQMCBj8C2KbMlDh1Y8lSg6P5Q9VSFN7rKT8fdPpyIKGlKT4nCljaYzd+HmmIYqRG5Q4L 9UKNeVfRSakRTijoy8Cm1eU3FSJPxAdZyWGARc8ChqvV7t6fH7qnNcoQzUPBSlm4IEmpQm9fzZHc 9fFXsFL5VdsFCL8ylJ8ww8ECJVxH0z4dJHihZVS1DeSv0QuxWUXI5b1IdyhwX7Yhwb0GFFIM8TVH Wl4BZZhT053XDgv1zHiFLO7/AGQkB84nzCDgj8qTA5D7qEgKBGO9CBhUeSyRD/4QAiVJ3c9ghnFQ pCQarqEsrgJoR/vcozhHLv8ApW39LHihZdUoSarOpTNslDgqlUKYEbLA1XyLbdSneioX6a5XLlXK uVcq5VyrlXKuVXM3RE2x4oWR0x2dZVOBvBsLXD3UlDgpeSEcwWpqd7eSr27llxRY3IxF4U9XeW8A oQGJ9BYzqqyY3ol7k4WnE3XokFDzWXFZQs4uRL3WZnpsEoEqthB+o+UyjpRkaV7k5R1jZnBaXa9f KX2TBSUOC09PvfyRkg159yoaYujXiU2Eb+JR/wDPrI/gKepif6C09K6J9QPyVwDDxxRzXLPe1w7Y qI3fLxwU5T7AI6kv9rJy3UUYf9FR08Lz9gpylw4AKeoL5eguC/XE1AceGPmtJ6PXxRlGpOO8mihp eJ8MEZBSrdGvfJQibwHPjh7lZB/tT8+inN6N69mChF3Fx477BIYeyHf9R+yNJe/FNOVO5NG7Zkoc FcFUJmCey69M1FUJ7HYOszVTNbQBVATsqJmDJyF8g9j42MyexmonZXK5XK5cpXKVynyXKVylcpXK VylcpXKdpumkocOrcOi//9oACAEBAQY/AvsAs0Twk8g6lfl+x2z63801un8w/wD0zhxPdQMnH73s pomWWHIDcAg4FSPirT15SRbs+XjS+auNeDSDVgyt5KtMvSkva/Yavf3WOFvaytHbrJ0WBW/nanSX eFfMCa48QQm7d3G5tT5McCT53LHaQXSIdrW7zXR3PAxdwg+aVKn3jc2rM3nE29cJ2Ps23M7tK3Ub 0mW/IKPJXa7ufOSTSSbplx7c0ovHikGSYjvKLy9811YZlyYb2ZlBVlJ5alPK9bfDKuiWOazoew6T W6fzD1/rWdGcl8mTp4GJqKr2+JyOPYamviiDKBUwPEW0kesCrE1gpLEMrPy4+tN1CdEa9igKRc1i b7hx6EMnSzcJiSoYdqnnY+eutsymPcMSNHzdvLFtQdQ101eesGGDEVc3JyGg6up+NtFuBNh6XGv9 Pix1zJ4lU5eVMWtqYXsiqVtWE8EF1kAGXiuzEB9VvCwsbW41k7R7KYcZMbq+2iRrxm17tqJW1LHJ JbHViZ5h2RJxZvgpkliMu3MvXx4lPpqw8K6vwq3fcWwI1mwWQQqHl0+K3Px+WtsxjgCMTkxZaB3t 3h1Oq9ZUEWMvs+LM0QhLP4gptcm96n26TCAxfpBGA76h0/Lq7al0RiJAxCxi5tbz3rP1t/nDCx2y PvMdtR+MCiGxBkZbOSXkLBUQDgAFIub1t6rtqzQTY6TToZJL8Sb2Oqt5zGxOrLtxHszFnGoMeGoK 3yVgYjY/+mzySKuU2osuiXSVbxE2IBrLgm2sxY5BXbc0Fjc9hY3sb93/ACthzPKtZ4nvqL2kHpA9 nf2E+SpFyTfJQ8ZeyQdhFXe/HxA0PNRT1VXj79XY3HdQYNa3dSNMAVHB71EYzwk+X3dwH7FPyqyf q4vyfcjjhhd2lYKhCm1zwra9phU9Db4NTtbgXft+Kpf9yZ0Yecj/AOuhby8FPnb5KkychzJNMdTu axpMrT7Lf/MBuVh4h8YFYU78XmyWkfzsGNbp/MPS7NlzeyT4knVwchgTGefha1yOdTtJmRvkeEY8 EN27fEzNa3KsCfrpjZ+LF0cmGXwhh85G5VjbHiyiYmXrZuVxEeongq348O+oc3b8tJHSOMakvbwo qsrAgcDatq3LAiEORG5nzMf9tdfltX+qYOVDG86r1sXJFijgae0FWFYC7e+PFjxohyJVj6a9QHxG +m5rNxsjLE+y7nCq6hq1QyIPStasxosvFy5XIjRCpbVFzJsy2uSBW39XKhTdcG69JQQGi7BwW1+V bthS5kUeTnMjQRnV6tvSIXhyrDzGXWuPKGZRzt21PuEW6xNi5MnWaHS/XF+JXTpt8dPuWZOmNF9K SDcm8ndYGsqWTcIG9I48aa7s7Hw814DtNbf0JsWTFxgqtk6PFpP63xFdQuSanfb8qOTFynLofEug tzDXHfWDLiZSTrDjLBIBqB1LfvA4Vu+M2cmPl52j2YeMEae8qOFRS7huSvJNIkUrR6m0xqtuo5I8 1bnt+dnR7isqBNuiUlyD865HADy/8qfvB+Vw/trh3VDIyFcaTIEOTNq77EX7rVkQrfQJmKoexm51 EuZj2aSNXgCqPe+Si1uQ5U1uFhxNfJXDibchRPo94POsWNDfxBivw+7uH1KflVk/Vxfk+5/ES+y4 cRbo6jou3AC3LvNZGIMmQ4r5KwJDqOjgQvo8udbXt0XhijUyaPwfAv2/d2z63801un8w9appViU8 NTmwomGZJQvpFDf5KCJlRO55IHBPwfYtDHOjyp6cam5HnoNkTJCDyLm32embJjib5rsB8tdYyqIT ylv4fho9CeOa3PQwb5P+J6VfrT8Ffrz+LX8Ufxfu1/Gt+J92v6g37sf21/Un/dj+2v6o/wC6H6Vf 1R/3Q/Sr+qP+6H6Vf1R/3Q/Sr+qP+6H6Vf1R/wB0P0q6a5ByDMyeIrptYN5fLSnSbW+Ws+GUHr5H BY+PK3D466gifUFHi7AF+WojJ6GMNMQPE2B4XPbUgX0jGbfBRMDBZbC7Hjbhx4UJZctpYtVyNIX4 hUtpika8l+5QSdxMnzlGn/xraYMV9DTyj2n6skk/Etcx8Pubif2KflGsjyxxfk+5uG6yC3U1ut+1 YhYfHekyeciSCX+8Dqradyi8WNlY9kby31W+P3MIzKUycsNNoPqxck4eXia2z63801un8w9ZffKB Ev8Af+5WPjrlw/QxqvpDn21u+5Dis03Rhb71P+xTGR2OltB0KW8fzbjhekgaT6V20AWJ8Vr2J5Dh WQ0c91xmCytYjieVu+9S48WvqwAGYMpXTfkDetz3M8Fnl6UDfs4eF/frbsGI61ycgO7aTYxR+IkE 86LMQqjiSeQrpNk6H9UOrLq/BuONAy6+OnwqpJGv0b+evZGe03TMxHYEHaTU8hmsuPpMp0t6/Fbc ON6jniOqOVQyHyGtnxZmVYlc5ExblZeXw1lSJkxvIsbaFDc27KxQ1k+j6srHh6Xi41HjKzmWVS6+ BgNA9a5twpsaPUXROoW02XSeRvXtaSfQatIcgi5vbh79TSibSmM2mfWCpU9xBqTxm8TBHjKsH1Nx A02vxpMjqsYZOThG4cdNzw4cfsJZbhemha55cBesaadQksyB2UchfjTdaIRMHYIA2q69h9+vDwb1 SeNZuHlRrDl4b3UJfTLCeCyLesuN+h7Jjsqoyq2tmK6iD4rcLio5cJYpMubJgxseGYEhmmcL6pHL n7m0xYSxSZO558WIIpQx8DXaRhpI9FVJrKyVdIvZo2lMkgLKFQXNwCOyv9t7zuOLjdDfZ8eGbFi1 rJF7V+qZSxOrsuLD3MxJ8ZYYInUYcwk1GVSoJJWw02PD3Ny3TT1DhQPJHGfWcDwr754Vt2VuMXs8 74yvlRR8QkunioPkJp9E0ugpdR+0tR6BZ21k6m+ZYfbp+p4ha0t+a37hRexXWfoEb0rfOb7VL5qe Iowt84c7U862KoSEQ93aakmkXSp9UG9xXgPAi4NM8M5iziwSPQeOkekfJ3V/Ucj943uFcPZ8eIvb quHa7W76h3fJ2zEU5Z6EOQjv1U0k9nLsNRwRLqlmYJGvlNYmxwN9JKiq/wBWnM/3m9xsCeCPOwHb V7NLfwt3ow4rWvC21IZfVllczafKoNh8INRy5DanjiSIHyIOZvW2fW/mmt0/mHrZsC4s03XlHkTl 9usnIJt042K+fs+OsYxsBkZVhE57HmPP3hW2YEfjxcJeuq9s0g4Bvh4385pokX/LYCFsg98s/P4R UwaxTa1BSHtedxz/ALq/BW47iTqycwsxlHLU/hRR5hxrZ9r1dHDn/XzsdIkSMam59jNTkA2xYFhx o/rPEz27ABU3tNvZ9J62rlpo5iyJMuGl8XBRhqUAc7H1vkrDjK6UgQZs0R9J5WGmNbd4rdsrKtIJ i0ZA9FIIed/P8dS7hOvjzpHkRT2IeA+Ie5ueRcEYka48f2/krFwQ1mzshEP4IPH7VYe2swXHC+0Z K/OVOCIB23PZW55U41Xvj6eyOJOdz5TW458ZHtW5PwP/AK479ONfPXsEE4SfDiE0BvbUYuOseQte tiEpXEGQDlS6h/iKo03v3VPk4xM2TlMVhyD6TyyeC497lW17Sx5WyM63aIuCoO+54Vk5CC8kUZZB 5ayryvJHhYinMYsfpJ2NwPOft1tsEjnrYsBlyeJPikFlT5TSYiGz58iw3PYvpOfxRW6Zgld4Egji j8fB5vve7mBwraMQzHIx2vjZnTc6xLINayXBvzBqWYtbpJ4Sx9bkvx1g7zhrryNkTTkRj/Gxf8Vf e9IVssPUbHxd3efcM+W+g9FB1FjJ7Lhlv5BWzLPkHHwcI5u8639NcZpGhxLX8hJFbftEs/syZUOd u2QuZK/gjaULBCxvqbQGuy359tbdtbZT5v8A+X2tUR5PFK+RlDjK/mjTn99asjCibTkb1LDtsHny ZAjf+N6gyMrOyHTaYidv6rJ0sUqmnrKiqoLKORa9qP8AuPdpcrGxxPNvGGnXkHSiF+mT4vF9GBwP 2zW1tum6FJt5mnyG25soxrJLk+NUMxbWBALDgefeawdjwM6efLydygw8/cMmWT0GibJIjmfVwKLp Fr2v31ibTPu8eU+ZmHcfZy19cccvV6cKsxPTVgv/AGaaw1PF4gO8dtaD71HcGTXPmNow4/LyDVEw a8+o9QdssijST5Be/ntRZ/FkSG41dqrUvEKE9BEFvjqbKzZ+rjnw48B4nnzFF4ppUKk6AjeE+9Qd 8mbwcSvL4aiihXx6NWnyAXND2vHTNw8q7JlKOnKp7mZbcfPX8dkel95+L933W23Li9q29m6ixg6X jfvRuNdfbsB3zLWjyMtwwjv81UAp8nJlM00npOfsds+t/NNbp/MPRZsWFmPNii3oCWFJQvoh1Bt8 NdP2aLp31dPQLX77UZRGokI0mS3G3demKqFLm7kDmfLUj9FNcwtM+kXYeWlhMKGJLaItI0i3LhSG WJJDGbx6gDY+SnkWNVeX9Y4HFvOaGpQ1iGF+8cjQmONEZhyl0DV8NdfpL1raetbxW7r00awosb+m gUWPnFBVFlHAAUVYalPAg0Hjxoo3HJlQA1rkxopHPNmQE0kghQSRjTG+kXA7gaKxxrGpNyqiw486 6Ix4hEDfpaBpv32pJHgjeSP0HKgkeagJ4UmCm6h1DWPv0upFbQbpcciO0V1emvVAsJbDVbz0QRcH mK6YiTp3vosLX76MgQdRuDPbiffoa0VrXtcX58DSwmKPorbTFYaRblwozBIxM3BpbDUbeWgk4ilX npk0sPjoJriVALaLi1u6kim9mkiT0I30EDs4Co8mT2RsmJdMU7aNajuBqCbIbCmmxjfGlkMbNGT8 0nlU00c+HHNkkHIlVowzlRYaj22FIcxtvyjH+rMxie3m1UYGysQwFdBhLpp02tpt3U2JJkYUmKyd NsZmjKFOWnTytXRmbb5YdAj6T9IroHJbHspMEpthwomDx4h6PTDDkQvKoskzYRyIFKQT6o9aK3MK ewV/H4371P7aORjZmORzdBIvD46R7xnB2eCNk8Q4PbgPPelyJITHFpOjsDG/Z5KSUMdcVun97apR 75AqOZ/CkcqNp7gGBpp8Yasdzq0/NPk8ldNI/pXOlbcay8mY3yp4+irfh8NIrp9psUt31z/xL/8A C2z63801un8w/wD0Hsrsrsr1a9WvVr1a9WvVr1a9WvVoc/8A43pVg/xH8DD+s9/0fJQ5+9WZy5rz 9KpuXvVD/Kr6f4HbUvp8j6fKtv5/r+z0fRPOhz5DlXb+ur//2gAIAQEDAT8h9QVALVoDawuJ28J1 AEBWgVdBERpKTZ/C36d1/wDmUuApocxute0eeso6KEPYihpMN8wFzQChvu+wjtuz8Su1JlXk3/uX jzrRnFJH0KZdgE9Q35atNcBenMF/yjRasSvXMQVKMqHCKvUdC+sv9mzN6nY7hOu1Fl8qWPK3Fxbj zTK75VZ8LwGaF8EaHZ1QAO+glnF3FR8zmgan07rAmUSG2FEW6hPvggz1E3lnWRlj2+FmFzZdq8YJ lwznpMnW1kXuWdsUr9ErWnXW6t8L3oFnUVaeAh668OJS4AmW2IQQLM2ZGoMtc3KMtnlaCGVZJQ8h 3QA8Md6lgDCS12LClLupgbleGWrZrullui224WNYRsxDo0EBDk57JDSd3HdPN1fapYHlJBVtr7wh oykL6735L0ghwg4Mpy13qWBbdaYYpgxYzN1mG9plhHTdhKxsYWa1H2JLzqzbC7oVwf8AlBQFpQ7s SOJ9lcwUtlthQzY4O4ZtWjOrW+E4YZVhYdF3hHpiPP2QvtBe5WD2IO2L2e0ZttDCEBzC2HMRxLC9 bVPLj0T0Sn3R32APh6KIEwS0zVbg7U0rulOrbPvO2gTn5k+MuY8tvKLwdA0E2GHZZZDsw7xf1YPU H5n07rD8JhhbLnZ5qtSzo1gt8AA0Lu5nPp6NkqO12NOe0wjLkFhAEYXTjELrDy2cKovzMj2G0C++ KO5vnMvHQri1vgP6j14lWRQEEqqKiw4p6ssKC9LzXeBnK1C9vwXWYkBKthpwAGF1vM05XDjbYFtI +Lbca070zbywwxTyXgUHWLyeR+ygXK5jo2M8MWRAvwFQBuSjk2sFCB0lHKwhmEFATVXiD23MKJa5 zc3i5PIbXLzAuculrB24wLXKxspOS3pNZDK9H/lsHH3VT7WjmtXSUL4orKhqx1XV7JXaxi3DHoX7 TIrjJQTa1FsLj8zNcLacQpQC8lSoWl7JEHJgoW5hz3TAE+HMvZperoC34l/t6fRuqfROn0W4VwvP cv1exDeGfEvS3AsyhBDVA+E/gt+ndYHdlA3dLZpHMpPLDN7pavg3/EDnqaMaaGszGR8u9dL3N5NO v5YVvdlp7IgOvChMtdETCmeMebP+Pr6g8p7Tij6d5wt7P9zgf2xwd7Z4ph4G/nWRAgQIEC+ddMhj lK7gPHq0PhAoFGVE2XQ+6AGMAwBTdjai7jHu5Vid1LxLvjA93eqmRsyPIbaX8kK+GBu9ZL8rLrrA ASw2LDnPtKQvqnkV6lC+0rFrBWhc6tJX9N6N0AHzA13UfZ6WFHej/LK/GUOv5Jin2Bc1sO9fY+mn vY3Dd1M8Felv07rCVx33VP5QRoR5AZe7MNAeqPY94BWG41tVPZuPGABILDCzbLrMNIswNIsbNVuJ lsVZ0Jl34jpK0lBVs6LPtERJcJqKAGtkPQKtQGVWUUHfSawc+K3HfVxbZUBw9G5sxZjaU6ZHBjQL AwHQLK4zqYfLOl5DDFXr2FHFvqElbeLFQoB5Y5/C0DmU9Bh/gtoi7jk4YmpVysqBdeOu5zt1UHCK tvArcBUg4L4EbjCGfkBSdiMlEY+wApi4RFC749KlPSGkRs7F2QJ0h9U3cGgXbgZqEAMXO0UjjiFo YhgUHiwS/mYCMEJuXtKI9MS3UJqSuEK6DN8SkqYCw5IhfEYwhuIYqJKYE95s4l1+ayDodHmULMXZ UEdS1hlpx6bYfDoDrbS29+iEK6qNxHb90DI1xLd8ZKWYnVKr5wHGsTEsIu8vHWzH8WWwaOV7hvUo KEB5FpLi+H6Mn2ERFy60UWzqa1BtqB0Echyw4uMvWy3i+kAEKnUFXG9X9IDgzTPun0x+/QJ2m05o U31jbnrFhFoIxZjqiQ5eiFsQU2UL+D8+moczu94n1yzFhZf30O04YLQFKqtARKrt7+lv07rMp42j Tg+ag1qvTutH7JeuEBSyN972mRdAZcrdRbZ8FQigPOcJ9mntZKGivQub9icvUxuKxdZ+1TjW5XUx Qi+vClVnZ2YhsKSnLsQhnsbajF0ouQikazntNfpVGrJdjXRgtiDigYp16FqYH2BsvSwdi6uU9sh1 nR3AO3mYCigNHEOTfxHK3X3UFYH7pzF8sdampu7Mem6ls9QOR7Jctxul1MjxGLJ4JF0dM8S+/wCw SfKIL99Su6+1XwFBU4vtFVRTe9WBC2BValDThs0wJvRHa+ssUhOscX2HcpK9MbV3gN1wCWNcCyxv +fx4hJzTRtXYW4NXkLWleVDp/PSAe9TdNdJVK+G4Vi7ziKFeVEUGJvVA7rTyXCysziHAojcdhqPY 8K0yZm+vQqs1Le8MFJtFizYppd3A7Oai6WsK5OzAM3PdinznH9oBEPga6Kh1zam4Nhky0d1d1/zt zgEWEedhQlAtntX3jIbXJvMTKTRWHFG3FxUs67Mw+JbOwz/zxGMWs5sZHRVO4dJbdssvgOXauA7w WjUlrBmr6H2gVMSEoGMwiUTcEp9njv7SgXBSjzKfrMIjuQQr2ZuVhKOji3ewQjV2EvlqSOENz7H1 p7N/Q9U+exhzAvkRNxFZ6i4pRd91j6rv7cDQHAfyt+ndYqY7fJ6qlzRqgHwAy23G8T6wVcDQKAXO uSu0qXywPWptntLUFVOrSusVHSSw4KViJ2CLvtYxF9EJhVg5GUogyLrIHciVZtqT1wudEdVP5mpf qimX7oKbh0Cg1AGgCHRDTWI8JNKCE3uEVbQNvdLlIWN8HFh4jZrCUdiHWB6ZI+EKuBCSih6JMSrR qR1CjNN2rniWaSLhrYlToK3UBMekyI7ElKLscN4VuzcAIiBFRodmWyhBFQOC+phj12U5rdK1hgTV BgAoHbBEY+0Kx1qxBLUmjxYaqVglbVGbGDGPGJYa5U7N28hecRv6t0AbimuJb0Ra4zboUXFdqAPz KjxdubdivWGKmAEIJMidGKqbpKLv0il4NQbzDLO6UnWopmeYyztpRYejBZ2t3rdobE3y/wD0A79E okGsUDPMGB8zEgQxo4a8S62inSHf3j7UVw/DhAcZ22G4XVx0jJBTMnesVAcuvdOH5c9YohrPFYcL 3Ln9B5/x2/Tuv/v+J8f5SAPmX6fzP+ffpZ7z5h/7n1Kb126958F5czvPlafKfTrr7/qfRn77pP8A pjZPp+uJ/9oACAECAwE/If4Im/46Ju/+YtRWcQG4yv0Lzqwb9Q0jvibPMXgBgISuD0eRX5j0Q0Zu gLPtLRrMAnWBUxst+kqwozGOU2KjarxBbD7EZQ1KIqUUqYwxNoJevEEDWYExFNWpQoallK8f+ZYK vMqaizJLi+rv03TZ6CYMBxBte0RWxAL1HZe83QFniUDcMjzAqY5yhKQZUfmJCFAuX2mA5IJZyQAL yygYVkx94JZKZzKKqr6uDYxCRTxDAvLMLlCrS+n/AJgmjpc3l05jNozcT+DdNnpd7CLVxcVV6tE3 QTqKNxDj+KguJp/MbRLXUWbP848p5TylOsr1nnPOec855yuzzCBXvMvU5RzOYxiBK9N3qC6BzfqF IvbNE3S4Ro16hASXEKxuILZg+nMa64Pv6c9R9Jer9EWphRjxEDEsokXEC4g1zEMehnr+AtqEEExC U5mIYQ/nfbowfTb1of4F15XpwYycMwLagAfSstklTR+4+00TdDUlASw6H6hfUP2l5eX8EGeX4nQA gPUz3WWvG4g93MKP49uYUA+lippx6Cl1zBl6CNblqGoefeeMP+sFyaf3Klc8Swjo/Es+E95QEDDu 48R5OrPiTQ+ql2qG2K8PMD/EZRj3IYs8xm7ZSly89RlqDUv67TUyoz3iK3+Oibp3oI1O9LdS5aWu 4I1LZcxVctVS3qtzAuZaKszXcEQWkuW69LS5dQV3OiUQgPWB6w607k7hO5O5O5O5O5O5AdlzJ6U/ 5G+5bc0gSmFKogjvK/x6Ju/+a+PvqfiPHtH+HZ17eg9P/9oACAEDAwE/If4ZZD4z/H7H9z7Z/wDM sdR9ai1e037v+pm/W6EglMfVHOXrDP2lI03pox7cxKIOVb7PH5n3oN9uZWc8ICmhrle+uJgdCCia b0+bfsS9+UD4T+mZiB/afbJbqgvY+C8ckEb53dX2RA9yPSsUqrXVW/iFdtq9DXfizxxN3USmqprN fXOo8WYY73nfGJm0nBWjlUb+0FfVoDVXkyXeGEyKrgV4Vm4jB2Hdo+ZZVW56Jtrxx1g9VLeLY6Yi zpWcD3HFe8xHC7xi+hVQw8fBXsr4ga22/XSU5xX+z9vx1mP4vFWvuOIwLAhjh1xAfU2wYrop+YKK A6U3azGyyWney12Ksrhzf/lAq6J0SaO3+2N8Q9CYv4SfX7h+J98/n0JVGJ/z5H19oeauX8ng+7D4 0IXeH8fhYBOgHxU+2R5QFDk7l70QUU5LjwBvctSRRMp2TfvBIrFcldX9F8wGeCu65VEq8xoLRZ7v xf0S/lDXIb4RGPRSWhbejmpVL7Sk43EWNvpWgWOjOfE7xJxjq3dbzFSttuOemY5fCo2Sqrx4t3+o DcsdPynhha1gN85eCPUnivF9l1gC/eHThVw3Wqz0ik7Ia0+HcMit3rnsuYk0QFLotN0z58Yl9lG3 q+1cr2x/5cJ5fY9F+ZrK6egwZjjcW/RXp9w/E++fz6PVX7rOM730JWBVWrPXfjEt7zj5y/r1+x/c +2QuyDviE2T4bidk9LL/AIvyI2Xkh9h5Nfzdox7tRK8d3E114N/42kp4lPEQhD+8F/aA4fP9RDj8 /wBR6P5/qdr8/wBTtfn+p2vz/U7X5/qdr8/1HBfcXv0UiYemxDjFgLMIim6ff1XyPxPvn8+nS1R7 7fao54VXtqCn0hX69D7Oedn4wT7H9z7ZPPPy/q4IsAG/mV6zR4+hLu2msC57tX2hJOTXvul0Yz4g bwYvvqut8VLsOTCVfnmdgUPy+8cyy9w05Gnk8QDLNpV7iX4sz7Qe78aOur8/Msp09h1XiJowpeHn Vdb34zAOpLIjYWXfbXzAsrTWeeIYXGLe+fxCZuxekx1zx3iW6wvWK8y1nRf2x1zrrAxhg3invcRe dNJTduit5gRsc09az0Lxnf8ADtAL8QP6Uv5gu6Vnzjh/r0o8BPucJELoRxj0P+Z16tPW3MU2jjqv WU9LlurWDE5AMELX9+SINRlmj0X5dHsfr0Nq6xydA4ZpunQM/KW/CRNpVfmfY/ufbIXkj6e87bD8 8feI1dP8vsfiMznvNQ/Nt+XUS5MV92/5MeLIdOjg+R+zjc7o7fFuA8Ge0vjyFxQt9vkOzEVcQfJ7 AP1yzxXnxKyQHC5K5z0fHGY2MAscrwfJM312djf7L81cUVlKeHH4K8efQOjQ/v7jMy5E9vqo1Lr5 gx3LeOYH14rvy/h4ljcf6HzWvniNwHlG9OzbPvHF12+gxvpxczcujlsD21WK1Lj/AN5gDrbg+Zvc D7yzkQt9jYeXtwhHUfdGB+R48RIbEeza+ExRIAZ329N4J4cA5tk6uH2ZevSKdr7+X+5Z2WXx9VMD pl9uJbU2/mGm4Bsm2vUxsdMqMCLjz/hrEwV1B0H7G4dWOk1flVgEqH8fsf3PtkStu8E0k+S50S3V FX1geAvV810lpRvfeZFpe2N+esUFVOKx8Siqa1ZdRYAt28vmBtFfflFzhndz8xQBTxWGABREBTHb E9gI7anuDABRZgayHQh1ACAV9pRXxCwFNNamkPIuUFhjXbxONO7n5iXhgWBXSpxGevM2Bf8Ae43G 7Kx8TCMutZnLt7TWt8RuL/ERm/xFf6Gf0Rj/AHCf8hn/ACGf8hn/ACGf8hn/ACGdOPDHUIvtKUqb enKlDMTwl/4/sf3Ptn/zef5anLW3+LU3/D//2gAMAwEAAhEDEQAAENt39tTttttttttttttttttt ttttkENfsDtZIYQdYZK4Ik1AxjdtttttttttsLKibHMzgzcSqz2tmVVMaNttttttttttsKBXeR1g cjdqZVtlmttsLtttttmSjya2222yvj99tnrtTGBZBUWYfWHDan4i+MC4IJSDK0Uzh+NfKQmCr4uQ 3S83U/R5N+IOIAI801909l9ttaLWYSxTJJJujmgdhb84gIAJZgNJJttttqdttttttttttttts1LI aSSSYEYzGf/aAAgBAQMBPxD1RMcMqGgAyq8QoVGns2IncgLWZKvgMxAhFIUicI+v32H17o/+YKEp RLVwEQLVC3TPbn347QkmFDQFvgYGVKStI8FAJSqXDdDCPMfrQTKg0bfEWtYWxX2eL7TQPRoDwX1e +5cAASZksv6GFVy5NS/U6xsFC3ggB9gmqFUWFCsQ8YyKIM4inphPmtAswTkzlSzhLOov9ViQDKBl Cglr+Y2LaoijS1q+USrysucD33BUWcPSVZUuLyUkojEbCvYRp+0hvbcQS8l4cOZ9e6ItgFUQKTKG IAuGdcftYcAUG5yJpll9ELxXRQ+cC5hwoXaoJQWsDWDGpqQobScVaoupHD0m5FiQGfAgE58yKWZ5 Yi1eMsruICgbDWTSpNB5nuJyOgPO4T15BEO0ZenKEzVLAljitFUG8suzlpShBbKQS/omU142q/Cl bxazFAoBWWcQxjdiiGjvdWeqVqnKwZ1Zc56oWrtqjEUZe6lf4gFIN7d2A8oV40VZU8AC7aIRNOSO oGFkbxB8ahIQzAcPfaxMnma+tqy7JpsjsDl5sxTzppYGf/I9ggu1KA8suEBhFimld+ekTlqJTqoy ApY/hsilgZbEBgNBBEuVF3WTejWqxR0x0hFgayGsHEfyg631b0LNcsoEhb1R4PsjQZ0lMbxzrcK5 s+0uefJKJhtIjWPjqfTfQ17JjuCfmMB14xd+X0PkviDYVQWW8ZlcOQmpptrJnbisEhMMajybHZo2 pFKSZ0A0LAwABEBpq6tCV29mBxM2sclvL3j690Rzdxd2zGMv5KpsozqWLgJ5CsWaDIMBn1oZcZFh pezDSGWBAmVVOteGNqM0fxAlZswpqgF/4FqEArU1MgvMkLitRROGxW76JSX9fWUI0pbgZxFLLhnS KoKJKyejKuqQgEXWDODubBtS8HrcOSFYuNUYQ1lLeLq5XZo+leTRkJfMY60YqA4SsBL6Mk/EVcKv y9JqMAI9rjbP4t4BbCJ6CwSZKOYKlKoCoIxRBj4IP9VOnTFAoO+JYwYbtIzT4UsdIGQYq5iDqAo1 MS4vFE4W/QfVFB/5b/Ghk43LtU7kQ2NTFj1A3CWLtLOa1tZmVsCEis0BGy1YB+zmUFLfb7UHqwU9 4McEVLBWjsTMWFN0KY5zAlWNRnoe7AkKwg5iHfE25gMgw0gRxiC7EqyUy7b+Z2Xj/GF1tkq98STa FbtKEOeNGTI2NbzL+MTIkteIev32H17olvirJS8kLoiF/Bf0UEIYGBco4BoEW9v4h4srQZS0QN8x Q7IXdLLSxfEEAlgKORyP8hzMCv6EQphWMQoKkJwXBmEMWmkrV4D/ABjy+yVV3e1/cqbs9rFBd/ok 0l3+/FNdvosUq3+9NLdrvyRdHb+W9evXr0+ZjFYqyS3tA17LQWn3XCXdhZaIYXl2NaiBK7AnRoqH S2/eAISIWIhyYQ6KDBKAJ26tyHW6grc0YWiFbFoPc6n0ahPBMoCuU3nUqu5sVVohFHeEKJ7Yliri 7e5UaWTxFoKVlPIeZ8lXY+fRHJU90H4jpdeAV/I9BRX3QAIL2x1xLBHdOoVvZh88RUIuGCyVu+hF AVaDazNjdlxYtZ6yeSffYfXuiYFqBrIar6W+0S5whAN+dqrGciFBBx6I29puQKT+LbDvHNMoaH2v 14BcCslFQM9j6zSqwQFVobLb4NG2CwQihXVE5SIhuNQWUsK//CoDRAtT2SGlAwSsFAAWrLJABpVs RMm16LjGq6gChlwQWVOMQ9UyKTaJiO2Ka/HiaYUqo8lZRMSBpPYgJjhIbXFAoOwqicxSGb3Mw5xQ UQtixKMAMKuAlxIz5VAipAsWKf8A50FB2XvDDDGZbAuhZIXbSkNsEfUBHaqXpwAZcFsrvqJgkNxC wXhjySE3VklnRJYcqfS2MOdd4hdoreNRU1/gsLBA0EgEIvFIJ2CG3dx8pGprzN8Nei2N1oJq7KRe wHkiSG0FUzp0W27oy6b4uAseqXWKw7A1J6bQIqmlyUBUYMJfcO8uQkTEdU3SMBTMsgimKS84Rpzn UqR8lt4Lheh1BCJE6PS0RJUjIuvRF+9FgfIW4s8IwIaoFYGdhkLYeAnhAWKqwgVh7WwitcZCgJRS lMW/FiTGWGhRuG8Ry6IIvEYhjF5XyQwVuxvohBhnq2quiKWGwxyHiuKAlCFFlV0uIj9WeQC0Blp1 pjr6HUGoRcUktFjfcckR5Ob3onzNwoog0ph6RhNyKIBe00NWsG6IErjnIBKD3gGBftLOvLntKElF 2InYgDr4+gCGFnstRCqtWZcbHw0cfQ/0gOTOYqi19/RBq95TPvsPr3REWzFxMS30AMcVbgWsF7VA mfPWIoWDquRcs/qr51RLFpTSOZd54DlFXaDpalkIXGdoSxYyqrWYI7E9wJ2ra5/C2cgYV33Noteh o5jBZHFH02JU6wMJFEZqr8nIkKNBkuDMS5/GLJpYOxsFUMxCMio2IujBzRbH7M8aLITv5UNFe1zg CZRWEuD3wBAOAAANAaAmzgzkDR4PZ1iKbmQAi3ASOYLuCRmapbEArcJRbQXKxsilkLnA2Y2ckSjV iZKsyssuHPa81wQ56aKP9tO0qWGh4dMBFUZyOOO1CxHFtMb1nfD+CsW8m1ANExvSZNoHsGC0EMLn 9IhWsSVMzq2yoLWDm4sZqHSfVRVzY84aZf1fn0AJ3DAaU2gPyg1ZkqBKgzZKVICCgc8jM7Wbtajx CkoJHQW5V9TE4CENA5qzAcNpIjVW4R4cmhG18QFF3ApoARb4Dcs1UHAC0KW18CqQdoyu0sSibwhB gl55ETndVcS0wOtxAFp6dLJToEIGKEMJShl1CiDelMVt94K6KUprAc7skXoV83winJ/fDhwwdfMo Nw/pzVIKco1koQXnuDbZskKFpD+MtKw3KyoarIa1kYdnhI2ZVq8MdHlFHDLjZFZdNmBODr9goz7S oEEwEJq8d61ZAY1QRtcbhDGHiWnYoK2HOXNk+vj6Hh6iGJpNN3c4bcvRVmX4ByCNmNZFY0o2yg6W 1gahsAANH8fvsPr3RFytaObUqV5ucm08wDEDRqN6RJp+uFBoauG3vr3aDDxapjA8MirgNWLcwM4t yC25pYIqqJY8MdtPSrJRLaa7neq2DJFYcLw2EFJgtgZCgi+gdJkeGW+xV9A2u93FC1uBRnhSuTi5 qAKnNVClhszAE7MPVQAAKAiKJjD1KLETYy6mLb0I0dLHrKnuYWgC34B1g8rhY7o1FbhEyZSbbgQX ku5iWl4/9sq53Ywv0Ig6E7O8qAVB7k0yPU+qqamBMktFsAzMynJwMQAA8CUhYiYRmG/WLpCnRAIs 2HSHIyZ1ZFBwLH01uSpUGh8GzDiZ4LH0FxTRZjDKRG4KmwRgLdY1AAvCE4Kdhe6lf4vMrguYMVVV DG/RTORKF2oV2MSsjQzdLSfAKhySlANOq90RajR0h2bOiAC4LLRgmRy6Mrdtb+lS2ytXZBtZkVWK qciIm+RVRlpWKnVUTqc5l2GltEXgCAyw21oWi47uMoXbYA0XFhFB2SrzShqw561cMZQQVJg05KVM YvmGMRbMGpCrAG+qBPa6eV8S+T8xtJcUWNJDGVVfiNzXRLfDfIisvU7gso0EL7thY1UCM6zyUgAS DbnBmHOOE4rdYASg0eCJJDYtosaGGJ9G/wDf2/xffYfXuj/3fHoZf8bf+vbPpy8do+sPH0HXPqxp 9FZz5T8G3f8AufRH9J5n1aZ1/DwnyL6R/tufTJ0PS//aAAgBAgMBPxD+GkJ5/j9/PvX/AOYZtmmw TDyuck/EWSETrHcxCZ6g8iX6Bbq3j+5eDo1UK4B4Xo7+YFSPiXY3UXPKeCZXvEAlbjfwNe8qLVn1 sjldj+p96yuNq0OPLFnThV13hAlotvR2xUaXi6Tv25qawEF8i8QJshq89v8AeZUhY2t77AkWwN7F 5viKxAWu3Hm8Q6Vxy9jbKYl7nc6fMRBulZf9wYsvDl+TMIDAarP+4vXJy8e8paiiXvw+zf8AqZba 3N4PZgCXEFy/7ids6b++YuZZS+lNU51AYqcs/fj/AM1y+OIebXaOWdyhZmSMw+iMowg+v7E/M+yP x6OgDmdJh92Mjzw+uv4iBLWO3k+vMVjbb8z71l2aVY8eH5ioovgP3LYASkee4wjV5tePEQSODXYB GBdSNp3x+alcxezg/hg4gALarPPEuoD3yICgjr29zxLtHS7fESoKK3x7Q3eGLwbN1n2VX7i5wM/e byeaq8vHHzDvkOa/Kr6xDQV5xHwmgcxsAorf+ognKoNdK2yrixQ379j/AMrpd8fO/sMBURtWVFv9 RW6Ky46XEYHiOK6TEzK4ShqAUr1+xPzPsj8eg32jV4zH13RXHSUi0Z/R6/fz71jNBfEx4TzALUHj +IxCDzFqC+P5m2j4IJgb6Tdh5P8AGELQtzAPMA/0gX+kC/1gnP4/uHU/H9yvX8f3K9fx/cr1/H9y vX8f3K9fx/coJa120f3BcLHdD23+aiHcEUXiHDXSW4blKuYYVyh7RnaLnx6/sSbfB+PS7+bfY/uK Dldx2HSf36ebD24+cz7+fes8Uz8R0rK8S3Qi3y/TNQcXlDHXxEgMGfaNhy0+uINqp1m7negW+YJx MG+WMwFwTBSx2RrznET0556bg9Zi694MgGW6ycbipsIQ2ap77ggqrIiDOaPbEUuqGtm+nmD3VLW8 3L3IUEZdVm/iJVjZd2VXnUEVcnc6Xjrj+FB1MyoA1EFU3j7+kCDT9npAAdYC59Bh/Kq/5Er81A4X X3ilYgGj+P1HDEzEqYlLiSbi9Ifn1UaI65cxw4INtkchtmwJr4P9votYdF48PE3q3quHjj8xEdgD 4n38+9Y3a6Pf6J35SZt3PH+zAG4weHJ8YrwQdzbj6Ov3hitvfQce78zxKV2Mr7uO8RtDRulwe4RB vkq+MB3bmP1sS+BLZRh/r8+Irm1q8Gy8TAfVPn/R9oZagHv/AN+/onXCv1KusH3gim1Oy7fY5jf2 otV4P1zM26fl2fXiYqtKe3R5CoStGFdFzBjsMnAM18756xKv0MvsZhIaWVcAU8Bv4/JBQGKD22/g hBLRv30fdgyQtV1ru66XMMRp2WYowkoCC3V9jxKr6lECr9j/AHCoah/LQUlMW7T7nDKc1ofv9H9Q gw5/KYfANneiD6kArTJmUg0VVxdoEBtlICdr1op3v0R7MZs9yuvAVHSWv8fv596wIoVeWbknhma7 X5YsZNdIpq3UxhbRrOoHkbebzLGyXFgFwagjUCyK6WzkGunEUbVs7xVywUbIBSk8sAoQeWLiW094 paqxTIvreYMgoPeboniCLp3MWTXTiDUUbtuWqrxBaM2BvreYKssSxhr3gbv7wnD5huHzBcPkh0Hy Q/vidt8k7b5J23yTtvknbfJO2+SUFI6bPh6kxqBLeGigPOd9My4H9e3YgQb1FrKEj20cn1xCkbWd TIy/o7fn/I+/n3r/APOlp32vor93P3nOO4an1i/f+F//2gAIAQMDAT8Q9VAtgCNOUfgsUMsG/X6f s/8Am6U0D5XoOWMGens+jVDzFVlv83LK4hqK+0Iii6jZEKY9SYZa1hTwq2Y3HFlsKKbpA07QfYIu k4tmjtw2TpO4qhB4UFOy1E9gVcCJZafAMuDA4AHgA+wBDZCoEJ6Gx5ItsosFAG9JrkaN1WY6+UHq UydvTVMGAxwNNg4LR29Mq4mATQ1wAvCeTpF748dUIoaoHOWaCJ4IgaFbmHBtZL7AxCxq1Bms9MDa mCocGN8QsAducrLUUgNrKtxKOCmO8HnCaAtWRgWwAhYErsznUXVUHWsXxLmTA62H5GewsGFJtBmG hV7mmmov0gnID2TXRhOaIzbWAeQvIKc51l8NOoNhdaDyL3i53K3aws4K/tcLfsCqAtl6AfaK5xDp AQ9tL4EHlQBQS1tWoCqrdsUQslWBSN8uaTtKSmai2GcxS936l+0ApgmOCBTve8MJmKLgpXZiSrIB tt/8r10Cr0DcSLFh0ur7j8cTE8u81K1C2DEBtAwJiYqg1Z6jL9FIa9NAXBVtLoL1cRvMMLLDwV0L CE8WYO2fA8dl1ANBoD6yu15ZdfhrsXKvaPZZrhZ4QPx6awNr6FVVeDkFjvtMsEpThsLLs1QHfGnQ 6o03jSqFmOLwykmuajNCgufcKqJ9BrJlCqATw4yXGpmdzPfb0daNJfpLZsd6Bld1jmVYKJuGAYEb u2+7G1PNLZeRRQ61hTpC1sUiYOwqHFhWBFFLZTyK7EtqXrGIQWwHQdELVl4IwlKhdDxfa9wcGhtd WFzVVKCekwVjsoVS1UVfBmFYLTEg0pqVgxbay58FOIxUWliUgQkkaOCRRcLusxkg4bCAVacNfeZZ AuY8KBhziOOGXAAmBnJowHMFIEQBGNC7Qowcr/5XJs1PyPy0Rcwiy9LCDG3glky8wRi0YsJHzQA0 y4o+r6Z0T671enC8mDHI4dGzTUWZpKNxry4bajZ8xbm0/O+r6fs9NW7LFoF+WNhJtAHuQqk6DfC7 /jrywByVkNZxAA50hbxe4N/y5dtQL7sFELqNu+o8lduinml/yZIPx/P9TjXz/U4t8v8AU418v9T/ AGdj/dGBf7sf97H/AHsf97H/AHsf97BwQHArW8HSLGQ0fn/kKqlUURBdqz8yrXV/mMcVfSvaWodP MWc761UaTYKvp3SW+mB+ikd+nleXkdlH4Q0ka94/SLi51O1ZHa/uPQhQuXO7S9A+S59P2emhZyQe XT+SVVGsbrL3bYxeS97WzzAaZyaC/QPlX1mNGKAoIwBZsFxk4gpVBUQvRY2YyK62TGWBL0ANBtuq 1mMWxYeNXsWXxFaQEos2QBKM2PkgKgBlXAHV6BKO2J2JiZ8ZXxcObGiKakcOVDwcYmIi9FYFp0Pd G0gqwa3mNBSvgzGvsyVVjrDkhDgyqK1PkJC+2oBVFCvKSiXauK3q9kGekWVKNkqXmAvo5MaFFaot aEXXZ1MmJy00IS28BV2woZYJU8XCX0gBvpjLgzA2OyQBC7JZGShxbwxdp4D0YXDIUNLav0qUwEUC 4dFFzVfkgxh0F0bVm3Al94DTQgByD0ClMvCBRrcMsXxddVcMC2tBu9X14s/qXKlqBfdilLj+a9Op 9fuJ6N0grDUOpRshWRGcwUQkfMx2G/0TswjmCTTBbgqu2d4i8QdEAsHIcmKuO7RqdALYLGQPjDz+ 3oKIysb2Cp851nBVHrmPwIpeSxziDDVFwUu6AqgwHYn0/Z6avqU1740vzUG+0uPZ/ogCigS6VbPv Z8phRSTY2j1FqsNO4KcK33DY8jbp2ErQROEQL7CS2LtpYDboeX9yp1U5uZdE3qlV3VKrNPYLeQ0I GejcKGawiqCM4GTPVtnXOqMvGYrviMrFWFdtODiyVP6gdrCrz0tHjMomDUMjbN9Ad6lXWLgc8Yny A7O6AB2hlRM46t0+hcAECrPFtfmC3AodfTOzsZAFQcru67CWF1aqNqHKWZNbWR8VWRwW8ZVUjZgU vKIDlpilZQJaxVdLgKm+BrGKjHKCs9rAhbFg4Ob7mKoyhBN4Jc11ME63oeGL7Dl7SpK8SuQF4DZS tJUWVdyK0O3rwMOIcgL46N92EvzAeYrtZnnQ6CGayXLhVDcUHMHRovqGIarpi+uj5ahg2FP2HtpH JukVp5B73bsMR3aG3qU+1+Ig2vlz5wffM4Luvr68zb+TkNkI80XC0bg2r6r/AHr5lARBSYd8Hvx/ qF27qXcr8fqIXoIi92/4CpPsU8qBewBRuplxNrFXhZXYP1AK6gfl6ryuX+P0/Z6aUvLKrK+auGgG aAp4sainLehGqVV94hJMMBg1bdHTUURCrQBbq9Xuzh+U6WaqlVisUxKPRVFK1VKK4i6RV0LOpZh8 QAbWAUattrvKYI0iXmkyPk4eIAbDX5SrudmNYmPTlUAFusAs3YFN83DQABQGADgOkcAI4RyJ3hc4 5U+QuN3DlT5S4ETLAdwVYdiOXhVAAV2obXmVqA3yHXCr77mELSBR0FMQYAhsoo9SxmTSw2BsabaT hNRQqoVgYdOVdrgBCxwjpJQOTeCru7rrdN7gSAvhoWDQu2pV1UurBqlUvqYephgSwKqilZKpWHUI iXwjJWravBjxKtVOjb8kKUo6Wr8Q2yBov/qNZac3/wBRi7Pq6S7j6btG/WfafX36n19+p9ffqfX3 6n19+p9ffqJ33x/VKooXY+TnoTAStehcajfwvMsXEjdaGj9vf8TSX/i+n7P/AIOvmfM+Z8z5nzPm fM+Z8z5nzH3n0n0ubfEefr2hNoahon9trXE49f/Z ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/rss_feed.gif R0lGODlhDwAPANU6AP///+J7AONfAOJrAP2jFeJzAP50APro1v63KP6xI/qLAe5rAP6rHeNlAPOa E/yVCO+YR/j08fS0SuadM/Lj1ei4hu2PCuaCAuuXEuzJlvp5AOBxGem1edGcVOe3Zul5APaEAPdv ANmyjPHax+3f1eyDAOd7HeymY/K9fPjly9NkAOt3ANGNSd+aQvOZL9JZAPnj1MiJS/fRjeJ/IPyF AOyjKvR0APOEHfO2Z+KXLv///wAAAAAAAAAAAAAAAAAAACH5BAEAADoALAAAAAAPAA8AAAahQN3k Eigai5eJTujwZDIyCWI6deR0gYQHwAUcJIlwIqArMGqdjojCRTHehTKBgMHQKxEAZx4vECxcBzgO LXkSDnEDDxYjJFwZFhwAKQ8DOooPChcxeSclbC6WAwoKJaQsXiCSKKIgB140H44fEAAVlg0zXSsa IwAqtRUNOg0LbDAaGiYQNjciJ8MmCwsvIQbX2CELG0sbAt/g4dxL5OXmS0EAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/link.journal.homepage.gif R0lGODlhDgEuAMQAAKzN3u/1+tHo/0WPtXityf6gFPX46gBmmfL38ZC80/nRgyB5pjCDrPbtyL/Y 5vH2987i7NXl7qHGxtXl3OLt6d7r9BBwn8DZ1Onw4QBZlOjy9+vz+LfCqebv9uDv/ez0+yH5BAAA AAAALAAAAAAOAS4AAAX/4CN6QmmeaKqubOu+cCzPdG3feM56ovgJmk9gSCwaj8ikcslsOp/QqHRK rVqvSY3gM9o8EOCwOGwom8/lsRrca/ew8Lh8Tq/bib+HR/Ndk9GAgH5hbm53h4iJiotPHh4VfX6B k4GDCIVvjJqbnJ1UPxWDlGUNCqWjg5iZnqytrpsCoWujZQW2CrQGqapKFUy+Q8C/r0UAwkvCxxXH RhB1ysRHsbO5CrYNubprIg4MBwsSIkkDAEsEBEPkTerRBAwOThZDDgNF50kA9XPsAfTRRtPGZKtV YKA2NRQsJHgAgIA4Y0UgMCDgrF/FYOfgkYM4BMLFdAA4WiziwJfICvCI/6AkAqEcEZcvm030VQFm AI9EHBwwlg9CSpwBAHxcOYRjyZsVgdYsVpGfO5giX15cGswmzJrAsDoJ+GegKYMHxUgY4AbCggHg iCSwwCBBgAEMFqCbt0Du27MWnBFYMLEI2gF538ZFR8ACYAaAnUk4y6CmhbroJCBuXAHxggM3zy5I GWDtu8VoW7KdG4DAgQEOALC1ew8uAwkv65lFC1vdOdV9DzDYnQ6tW34MDGem7dd3AAlsGRxPPnxz BcMMIDyH+zEJVwRgMTTAADYsmHMizkG4B0A5EXVjAzwXdu8t7HPPQy64OOA9gfTr7+lH1zZfgvJD zFfBOQwAkAA6FWB2W/97IAXwTmkEAGgEZkEp9xyEAShkRD4YAmhbhOYFcIAvDzZEQD38cNhhiEGd U8+DzsAIoYkOLOBSjTYtwdVAE1xwwTkRXjABd7moIYFDD+yVDwAPiOhXOe05NdeHDhg2AGrnQQkk SPthaOUA/+lDzgDnWGDiEJjBdSVpb5VD4ZL6FPGmPgqiQ48FsBWFoktpaqmik20CINeVbcbWIKBB DVoPhWj6hRiZx8WlmKRN7GgGBl+dMcGR3gyQQVwZgHkBBUWKkdBCqiXp0IlPotRYlfYQ4MuHGZb0 EZWvytNla3YmKp0F61Vg41g1KVgPZw2C+VaEcRKBWU10YghbAnFyqB//iuiQ+SeF5FxbqJ6+eDuE t2BW8FsC5pZ2rHpaLsWgEgGh0UABmWKQDwH0uHWAR2eZeMEZCuByhhrd6ObAAwOehqxpbhWW1ksW ZKtlohE/iaHD9l2MDgQDHICOoMG55RmWpnU87mm3lkOPx9AeAVhq0cKHsaEJY1mjYWE6C1IFgEHK j7ALqFcyZzwbZqc3R3t88gA+dRzdytFVKssZpdxiAAZPdTZAByKWoxo8Y0nA3bz0orENJv8w8acS NbrybtqJTCOvNdfs1VY3Fe00LgMRJBAyprYUgI0ZZxcCN9t5KqFkKxxXd/gdcsvbwOQckHNgXABE ICIEHUCQwGkEhMlB/8ABD074GLw8rvrq0UQeyATKqhexmroh5k5jQ1A7ASWFt8H678Bz4jogxHbE dGqmhS6UoFyrVx/vYVDARhsQiFMEM4dgX4XjVdCUVRPca9+E+El830oslMDuVu6yOssZx5ydSGol YVgwvQjCWk+EPIq83X3QcdCVxNTWrP1NwR9PYAf/WIG+SVwAS+kgQPNExJkIQEpP/5oEGHQCAAqI wCMMwR9HKKSVI5QwKB8pB1VigiH1IOslwojKUYLCwqJwz4XFcJJHJEKRjiCrJEQpIaM6YhOfqARm G6rIUXY4EWeMyCYO+MgM69DAQORDc0Noi5w4swFWDcGCGaTf0HDjkP8DIEwz8HgWdKoznahdaQG/ 4UtceCMiOQ4oMowRBgQMk5fZpKVnFkhjczSym8QRATSUsUydPNMwvtSjMNqqh7DQIshDTsYxg+kH Xpr1xt9oiZEi2o154MIao0GuApSQTBT5lYAdQuAArfSIA9wRAVm+BnoIOAAYytMDMz7gQJDCDI6Q MMyiuMg9DoJNgUQUrgPxJ0zrw5BePqac+nQGHXU6k4aQ0B8wHUg9dSqUsGZ1pLmoCJjYvB6BQmIh XbklPS85Jq3YMSIHOQA/wPLfHKpIvAwc4J8ADahAB3qADAAAl7pEQD56mSQy5WYIkpnPESLaEkUV Sh3qoBCQ0PGlaPL/g56F4lCaHmUnwBhyCB1tTzjVoaKN6kld7kjnecoUkmixtFoWnSefuDSlMx2C n2iQjHSWYaNlLGMnRo2AO4wqEQkgFAEUWKgIzGjNYLILQuNRiZbIVQ6Muqmr5VxWP2LVmTuqS6z3 MNZYj6O10tCnV8QCwEoh4pzNtIdDVZUpSola00aJ62LYEis5fMEtAHQDJQJEBFDP0BMiwHEDzoJJ B7x4kwGEURBgeJlUH2DGGp1FX/1wGgTgGVrdSKdnA/SqiDpGmI2x9nodG8AyhvaWnhF2adLBWIIi 8trSnOaRhIHlcRZQsbseqy7KGuLIkOikol3Qeaa8mbIYBijbPCZj/z9FpQOlJAy9fTF2QbEsLgmB NiboMwpDvAI/nLC24LmXCIu91DmEEN4IbKADHdhJBzSwgW6k5APnIBL9xJC6JUgHC2y6QvugUIEb vvd3w0ND5f5rI2oBdCIJSAAAQzu6yZnudAQu74NHTGIqRHhe1lAAfGoSnAi9MgEOsPBgLUgAutHr w71bRYl3zGMdhUJegWsA7NSUD2AcICV+o4cjJ1A1wZktDBC4Xw+iGAdgOPhx5OtxJ+IFsLIZYAKI cUAXCaABCmrSAR3oxgB2ZwAUY1ahA7iEGzQcTStE6YWrO6+Wtzw1wpVCwBTYS4T0uxOJoOZKCZCX gNMQPQfIOYoIE//PVY8YkxWiUGj46oeVkWXEJHQah0jRNA0vTcwfXsQjb8MJlatyvZ9wrwB7hgKX afGj3cjlt78lAJtpIYZ8IACSePJsAkAj0drdxdZ07KRnB2i3euDGLhtaDR7hYi6OSqAbgnnNEU7U F2BPiy8VKwpboIOn4YYmlMqxW4IDYItYb0UW2MnGBAy0UQlcYNGo6DVZwDMWVdkTQ/VEpraXaSLg 7mwB5ATQhTbUTgdB0yw12tI2jzAe00irHhJlEIAkc5wXwSOtNDGToKoTOHcz4TrdyRRYxrBQ8LRc piLN0kXlcyKDB0oft4nWhqLV0QDIRcPquNNJhXWOcMa8heFN+tH/j16lK0GQCIGDtcmtA+94D4Rs 3VHDyxmy72z9Rq+q7RZhgDurctSVuZgxkKGcBKmUmIZjAJwW00iDbZ106EUS4BlpOMR3FH0dUYFs 8HGEUfKpU10gXrmGQdaw9ZeXtn2MCrsxUBuUiqGHuB+L2d6jxTGlDfesA7ouaX1LKPIc97OG6vvj b1sUzCcT6lI3PBKuA4ZsYCBwAiuVGlTRpFY8HcHrfkXsZS+NqndlFKU4he53L2JW4NkKBya+e2l/ /O4MmPnNl772H0f96lsfxNg33PbHz31IWOL74A+/+MnP/tYJQASWsPriLcH73rf//q4oQQ/iX/vl +6H++BeA52MCGkZVgAZ4gAiYgAioAwzYgA74gBAYgRIoAyEAADs= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/icons.email-print.gif R0lGODlhWgAUAJEDAMzMmf///wBmmQAAACH5BAEAAAMALAAAAABaABQAAAK1nI+py+0Po5y02ouz 3nyLDwrdSCZCgKZiiYRuyC5nGKwxmObop4k2c9L9IsPGp6bb1ThFUw3XrDSPyFzQxmu5BjDfI2g1 Zrs8kIJaTa/WLQPbzY0DX9sznI2XgZH7tbkMF/cnJwNgeIg4dbcoqCckFGgSONZ4RncpWelVabKX tOSWNRk6OIV4ejpkJrfpU3T5EuNmKIBKS5uJAQsjy0ULi9vWOzxrixpF3Lsbm9zs/AwdLV1SAAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/txt.search.gif R0lGODlhMQAQAKIHAPHp2vfFd/m6WPXQl/Peu/uwPv+ZAP///yH5BAEAAAcALAAAAAAxABAAAAPL eLrc/jAyIEoJK9g9WBGTJQTEQlmdEmBKMRSGAbPw5i5EDOAybKQCQ8VQOlgWhoDuIAAZDZBgklcC xA5Wp6xVQGqIDRhEGKS2oLkiYGfsKpI5Gfu5macHBnZuBAMpix49M1g+KTUWc2VWLHExATt/DoeD CnFnDzIEOW5pewp4gAtHbytFMDtiDY0xeQdpTyU5hk6jB0mZUmeamjtBbFYdr1ZuOp5tXnishqwx XVtIXa9MYKtstVMAvBLbEdkEc9zh4uPk5ebn6Onq5AkAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/but.go.gif R0lGODlhHgATALMPADhqm7u6u26Uuv///7TI2522ztbW1pCPkYqmwunp6fPz88vX5PH1+eLq8VN+ qf///yH5BAEAAA8ALAAAAAAeABMAAASm8D0iqr04V0TkXEMojmQZMktHgGbrDqnwzqRiVHRuB3jJ FA4AAMGY7XokAWBVGBoNPBmJsBQVCCGKoFCDIq2AUGOxaAyoV6foKB01QwhhWOCAh9fetmhRDb17 b3hRJkorBEEDTQ0MDnpsJgxxQghmA5ICRYJfOS2PnC8JeSEKCaWmp6ipoQEIAisGUAGys7S1tgEH ByoICLm+v8DBvwUeWhrHGh0PEQA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/dot.CCC.gif R0lGODlhAQABAIAAAMzMzAAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/icon.bullet.orange.gif R0lGODlhCQAJAKIHAP/AYf/Ri//Jd/+hFP+zQP/15v+ZAAAAACH5BAEAAAcALAAAAAAJAAkAAAMq eBdAFOqIUKogi15QQOvEYBDFMJRGahTGSajkwBQvCQgHwVmYIogG3CEBADs= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/dot.clear.gif R0lGODlhAQABAIAAAAAAAAAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/10/dagger.gif R0lGODlhBwAQAPEAAAAAAP///////wAAACH5BAEAAAIAIf4lICBJbXBvcnRlZCBmcm9tIEdJRiBp bWFnZTogZGFnZ2VyLmdpZgAsAAAAAAcAEADBAAAA////////AAAAAleUJCIiAiCEEEIAIYQQAAgh CAIACIIgCAAgCIIgAIAgCIIgAIIgCAIAEAgEAgEAIBAIBAAAAAAQCAQAgEAgEAgAAIFAIBAAAAKB QCAQAAQCgUAgAAgEggIAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/bull.gif R0lGODlhBQAHAPcAAAAAAP////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////////////////////////////////////////yH5BAEAAAEALAAAAAAFAAcA AAgTAAMIHAigoMCCAA4aHMiw4cCAAAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_here_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISAABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxInRgSQcMAAhRwPevS4EeHIjwczXiNZUmPJhhAphnR5rWLM gxhnuizIU2BAAAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_down_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISQABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxIxaNx4UOLEiACubRyJ4VpGkh1DHhwJMqFGhSEbQqSo8mPK hwkx1rRZsKfAgAAAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_up_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISwABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxIPYsCgEADCjRsjerwGEuTBhSVLXss48eTIlBxXemwIkeLI li4fJsR4E2fBnwIDAgA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/sim.gif R0lGODlhCwALAPcAAAAAAICAgIAAAICAAACAAACAgAAAgIAAgICAQABAQACA/wBAgEAA/4BAAP// /8DAwP8AAP//AAD/AAD//wAA//8A////gAD/gID//4CA//8AgP+AQAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAA4ALAAAAAALAAsA AAggAB0IHEiwoMGDCBMqFAgAQEGHDiA2HCiRYEOICzMqDAgAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/prime.gif R0lGODlhBQANALMAAAAAAP////////////////////////////////////////////////////// /////yH5BAEAAAEALAAAAAAFAA0AAAQNMMgZAJgXa8q7/+AUAQA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/beta.gif R0lGODlhCAAPAPcAAAAAAICAgIAAAICAAACAAACAgAAAgIAAgICAQABAQACA/wBAgEAA/4BAAP// /8DAwP8AAP//AAD/AAD//wAA//8A////gAD/gID//4CA//8AgP+AQAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAA4ALAAAAAAIAA8A AAgoAB0IHEgQgMGCAwEkXChQYcOFBxk6cDgRYUWGFC9S3GgwY0aJFgkGBAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/mu.gif R0lGODlhCgALAPcAAAAAAICAgIAAAICAAACAAACAgAAAgIAAgICAQABAQACA/wBAgEAA/4BAAP// /8DAwP8AAP//AAD/AAD//wAA//8A////gAD/gID//4CA//8AgP+AQAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAA4ALAAAAAAKAAsA AAgnAB0IHEjQAYCBBwkmNFhw4UKBDhsilGgwoUUABzFGLDiRI8SHAwMCADs= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/lambda.gif R0lGODlhCQAMAPcAAAAAAICAgIAAAICAAACAAACAgAAAgIAAgICAQABAQACA/wBAgEAA/4BAAP// /8DAwP8AAP//AAD/AAD//wAA//8A////gAD/gID//4CA//8AgP+AQAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAA4ALAAAAAAJAAwA AAgmAB0IHEjQAQAABQ0qLIhwYcKGDxMahEgQIcWFFxtmFGiRY0WBAQEAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/tfig001 R0lGODdheAApAPcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///ywAAAAAeAApAAAI/gD9mftH sKDBgwgTKlzI0KAjeA0jSpyYkBalYBQzalzYbc+cjSBDFmJzLqTJjKbKPTrJMuIlUBBbykx4jNO1 mThz6kx471cvdzuDCmUZLx2ufENZ9kvnLynLfcJyOT3JbROzf76kCZuqMdsjdASZeZP2ix5XieBk lfvHC5fUdWclygPGCywve6NyFbsnL+5Ca7LI/dMG79u/d34j2sNHUNm2b8DqzeOXOCG4RtUOIq68 EFWnhJM5HyzXKRrBe/YOM1SWeFirm/5iNw0tuuAsXmv/sZJaDp7v38BDAR9OvLjx4vsKRgPl7B+s bKdEbZu3Lp7169iza79+vDvweOVY/g38Z4vUYdnoZa9Kz769+/exDX7KRFBXt2Wsps3bB7+/bH7O xOPfe+OMAtc//FC2mUKrJAbMZ/+gU0467PxDD2Us0ZPHPCalE0lMBS2YUIN+QcNJQhe29AsAxyRU zzf6NHSPQeZUKCJCJJKzSTtOsXMIff8IYw42sqyTIkXvUNOUOKm40007yxhkj1n/2OFAPw1BY4tg /4Cyyz+9FffONXr4hg0j6nin5nExWtgMMgTx4o4vuBxDDzpr/qYFEdNI4wUF38AjDBC7+MYOERlE U00hOrwTDzzbWTcOK+MQ9MxNNxb0yhcAGIYEAJk5ZY0qBFUTDznP7HNkROp8k4MK/k1lE8o/+4AC ACXhhFPOIGZgaY83jBVkDy9IhdhIOJopxAopguxixw42eOOUP9hA42JyBsHxCUHcXHPPN9+Q8w0j fHgDThUGZEMOPugEy5A/5ARTw0HRPNJNsgfdsg8ro/xTCACXnOUZQexI+k8x2hCkDjjhZABErkTA cM453gD1DjJNUTIFtgf5M+M/8eChDTjgiAOVGukYJI0syP5zzpflvCPzzKU0o8Mq74SSBzIz9+zz z0AH/U6b4ZQi1T+05BJLLM5MQAQsquDiCzAQ/DBNNzJ88Mw572jDDSVUaHMOOa+wA487dEBDTTbf uGJFNNIQ8gA52BEXzzq3hFpM/iqqHbTKJgCg0qVfwpTCmizA4FIKOFTgcVAYcJQDzhIw5CoOY6sI 0o86qFQeDjITxFLQJVIkp488HCtEDi7ZFNTXjeAkAMUzpGTxS1z0MJPKNgjVk/pBiUCxkDGXpNZS NLtUaNCN07hgnhQATBNXPrL4cm1tBakTTcr/XGNN3+y8Iosp/1QDShh6gBXXMKUUxAoks/xTT5vY n6NKy/kY8w857zQhAQAwGEcuzgCARAjtgDPLk2/otwu+EYQVjMCF/NKBwAoq8DjxUMdDCCIMbXTC Dbq4AABqoIQ+AIAEaABGZYBBKoK4ox9gmR/2CNIMW4yHIEsAQBeooAJUcOEN/j4whGgw1Dv61eYY uuAGQWLTCCs4IwwfgEAINiEFXpjHWhYjyDvqkQ/E0CMfQJEHPxADFHfUgzFkVA1q/gGUg0gDFTwq HzawIT8jKsQfWGpIHvVomVI05x+3sF434HEOdmRiEtJQgAQGgAUMkOIFn8DBKxKxBDPQwQec4IId ePCJLvhhBqB4ASSQkAY5MOIJr4BBKJjgiDewoRUvMFubzjEJGxIkEYqQoD3wBBxHXcdR7lBHpLBj Dut4xxx228UjWvePXeiCHHH4xxjkYQxH/EMfzUAEGJRwBwmMQALFuEIFQPDNMYignB4ggQTUSQIK iOAFULCAJiSghgpQoQUo/nCEBFxhEHwcA0L/6AUrhvGPcQTCIN4ohEH6UBKnaOMYLaPHjMqIoHjM kBi1SAg/mEmQfSSsINog4lDEsYqWzXAhydhEQvRRj4jgQ1XvaocMGcKOe7iLW7fgEkG8MQp3zaIX 1vuHOURRC/39Ixu2AAX3lCaLglCCFhkFGSh0ocKjaqIVzSCIKkQRCir9oyoSREgueBERWIyVIe0o BS56wZB7hGKtEYEGLLzKC2cSJB7M0IUuCNaJVhjGH5e4RFj/AQ5JHK0ZoXjFXv/RD18EkiCzOIQr 2viPcNjiFgnpxWAX8lPMLmQdqjjrQuRhCrtG5IZgoodF/6EObLCjTd/AbscNbaq+f3iDH+ooiDjm waFr3uMcTflHO+CB2nftcSH4wCND+HEPfgRXIf3YRz+ee9LqWhchs5jFONDRjmJd10KlMEUztHGg 7/ICGZ1whSNEat197EIUf7gFWb9bPm1cAxlGpS8+vJGPsXDPJAEBADs= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/squf.gif R0lGODlhBgALAPcAAAAAAICAgIAAAICAAACAAACAgAAAgIAAgICAQABAQACA/wBAgEAA/4BAAP// /8DAwP8AAP//AAD/AAD//wAA//8A////gAD/gID//4CA//8AgP+AQAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAA4ALAAAAAAGAAsA AAgZAB0IHEiwoEGCABICEKhwoYOGDBUenEgwIAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/utrif.gif R0lGODlhBwAKAPcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///yH5BAEAAP8ALAAAAAAHAAoA AAgYAP8JHEiwoMGDAwEYVEgQgMOEDh8iNBgQADs= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/tfig002 R0lGODdheAA6APfyAAgICBggObSsrBgpOTk5EFJSYkpKOf///zlKMZyklGJic7S9tEpiSlJiUlpi YjExGBg5MSkpOTFBOUpKMRgxQSAgGAggQUFSSlJaYilKGGJiampqaiBBKUpaSiA5MWpzc2JqYlpi WikpEBAYQTExKSlBKRgxGAggOSkpIFpigyBKKSBBIAgIGHt7exggMdXV1Sk5OTFSGFJaWilKEKy0 tCBBGHNze1JSWik5MSA5GFJqUiApKWJiYqy0rCApMWJqcxApGBgxECAxGIOLi1JaUkpSQZSUlCAx MUFBUiAxOb29vRgYEEpSWilBGDE5Ob29xSApEFJiSpSLi83NzWpzgykpMSA5OVpaYikxObS9vVJa SjExMRggKTlBUkpSUhggIJycnBApOdXNzZycpCBBQbS0rBgxOe7u5kFBSmpqcyAgKSApOUFKUhgg GEFBWkpKUhgpMSlBEDlBQSkxMUFBKVpaWjExOVJSUqy0vSA5EEFKSmJie8XFxSkpKZSUnKystDE5 ShAYOTk5Su7u7pykpBgxMYODizlKWikxUkpSSiAxEDlBSiAgIFJaaouLi+bu7hApMVpqajEpEAgY IDk5QcW9vUFSUjExQYODg4ODlBApKRgpKRAgOQggSikgGDlBWhgxKQggMSAxKRgxSggYQRgpECA5 IDk5ObS0tBgpIBgxIKysrFpaaqysvUFBQUpKSouDg0pKQRAYMSk5QTFBQaSkpBAgMVJSakFKWhgg EBAgGBAQIObm5ggQQRgpGBAYKRAYCBAgEAgYKQgQCBAgIObm7jk5IBAgKRAYIAgYOaScnBgpQSkp QRAgQRgYKd7e3kpKWggYMUpBShApIBgYIBg5QbSstBAYEBAYGAgYGAgIEBAIEBggSggQIAgQOQgY SggQKXt7gxApQRAQCDE5WggQGAgQEBgYGAgQMRAQKRAYSvb29hAQGBAQEDE5YggQSggIMSkxSgAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAAeAA6AAAI/gAPCBxI sKBBg+tqKUF1sKHDhoOU8DFS66FFh6hWrROw6iLCA+tAigxJcqTJkusitlBmA+XJly5jVhQABpaR KTBzxhy5qhIhR0YwPdMp0qNRkFL4gDECRmDIow/XrVOGCgwYQk2fQm0IBhUfWEuzWny6syxRgmSJ mi15MO1atQ3dviy6dh2vu8Xu8sqrl6/ev3sBC/YbWDCvM4YT8xqkOPGzu48b/0XMq6hDa+i4oEvn DV4ATpy9pbMFxxa4dODAwUMna1M6eK83w/tFDJQoUWh2pUsnS5ZuWbuB/+IkC9yubrbS7Vq+6xe2 XezYVTnVblu7O9uya9++DcC2cduW/gDz9d379+/n2lgHP2PJNqc6rYn2FijagGS9eqXrhQ50sv3z oeMCHL8UAk4g6Axgyy+8bfZJOtGk8wtrv+wiiy2BHMPFJr8gM5osv1RIDDJfIIPMLsjoUQUy7JTy ShvjADBOLjHWCMw1vlwzThO5tDNMdeP8OE472LTTThvt5BJHKeOswgcqsEhRSy1DKXOAla0kE0gY nHDACX2BkJLOCN789w59oo3AGjiQpPPff/ShE0ggbLAmy4nJNMfbL7aAyCcocCiHDG2ptIFihzcg gw02ubyyjTlLyDjMd0O2c80SRgZT3abVAYNkO0MWiY0iuWiDiUAtoPJCJVM8Y6WV/n94Q2YgnGxG ShLi0IqOrFr+14sZWgaqpX7JyFKfLOi48YuxyzLYDTLoeLhcb4c+m0oqukBXITIhRNdODm9sM+k1 oIp7zjBLXEOukey2AwC7uZhjZJFtrLtNLVO8UJEYlUhVkZV4pENKmQAOMEAYZlghSzLzpfONaAjO eWw6CO7qjTdsdFNfiLscg8yd1LCIzYkhpnPiib6USAx0dbSBzTkPvDLpjO5WV0opihhpHbw6txPM NdZpQyS7MqLVUCu9oElKILJevB9+6ZxJZjIM0wqBLHD0dkyIaKLBG4i7cHKMhMdBx84vYSADySYo auILF6kgs8kx7GAQnQntvFLz/rvg5ZLLNk1so+6Qgjch9I/tsis4ue+xFRMeHpgx5qxl5idmLwOT QuYAoHljBoK2gPILOHGn00wgXcgiTG/gLLvL6oMS88sxxxBH2y8usNMGi7uk4sQl0fmS97s6D1Pk ONrkoQgUm5qTSwaKYLozkNaZs00NMxoNn0gLjNkMmPgFMoL4I5BpvjcBDOx5b7YsGOKEu6LRTToE MtcNiL6lows1v5gxgIkhituhdsGK6CyqDY4aBo0Sd40Y9Kgd8vqONoQgLyNpYxwVjKDw2mESugyk FZ6jlZhIMaBmaKkapOgFmUwommYMwAyk2YwMd+MNWXTBZGSjDYgQFKJ2zA9D/oWoUHNMhKJyXAEb 7GjHOXTxCqF9h1xA21QGcgCkdkmwZ9YpEru0sb20iCRWIfRGCgMBiUDghwJzGoGWRtCM00WIafNh WNW8gQTfTIILzxqUm2SxjF+042Pvox1tUNSNXziBEgZclKMwOD0jgScHS6jUo65opAxacRzXsIwH QSKfQABrTt5AByjCNIIweFJ83rgP6AIhi2gEoIYNSwY6cNGm5uiGOSGKEHSetZytdWg5v2DHFdrQ BnZcIzqJqKK8FAHFUliwZkZ6oHXOwymdlQI+XnwKCN1EpjjZAh0jWJotxFgmBMHhCBxAljf6hA6L bcaGH0MNO4hxDGEAan7d/uiYB4gRnfd1CBkrc8DuiOQLdrwiZ7lgXDugAAUkbaNHO3souypIrgoS KRXn4KBc6CKfpYEpEO0TGNMGIL5A6IcTcCiEGdRJMVtIbgDISocctOUCYYzGQiE6xheO0ZxU/LND EXBCBNhxBzUgkR3YKOYrrHcNaVYwF6XIwJByQUErbkqLFjXS9rooEMyEpobo4ACtZiUnhl2sfd+U xZcYNiZvhMEWEMAGElC0CVDo5kTRCVswd3EaJA4xAjSogi5AQAwkFSmJiZjeo6CQhwcEwUhCeFQS 2xEDZ8orXla1lKU8mE1r9OI/c0IHHODQzv+QyQxmOEIh1DqAANgJnN74/qw3mrGbdHThfewY1C+6 8ZxfRON2rfvCcpBRDnb04BhvwIEvziGqJCVzXe0g1SQtlTPFxaGainMmz7jqQcxcLJQugEAhbDEA gc3xQlYoBHGC9Z8RilQY0WADOzYB0HTkc7gWggBP5bbbExHjCw5wAQiQ4QtfvCwXitzGjQQHhZ1Z rxTnyAXzzCGESlZHeNVL6Lzw1kEvHqAVBILDJmQxts0kgxRwYFoglkFSW4BmBKAhxTKakZ9Z/ce2 g9JTbnE4KC5ABxmqMFF0dneMNCDDZYuiFzZeAR4IbqPC1kvSEoKRgxz0CFPtwnJ1sFFhXSTpPQPJ JiczkDVwoAMcvdGS/qzmlIxxhsEKnPCVmpnWXjO6CQ0mKkdzcnvfkkXHrtBBETZS8YMd3CEE0kBq vZT4Cg1HNJrxYmg70tUObeTiU05mVx6q88AOb9UaZtAExSKmXk4wLRr9IampXcAJzIGyOBEzY3HQ kNfdcuyf0cDGLzhERGTo4gsa8EEbNuCIFujisO0waDAER91KX6o6VNRGEhuJDcUeKUmb4m5arAGO 5FhMrciys36qEUo2m3R8CGIbOKiGO3Aswmwe8qlz8vlLbAiXd1xIgw+wZYMWJMAE1EhqO3zRAChE uR1NMFJ1rz3pCmrjUxEsBwQTZ45NelEJs+sNffpEHE4QBwLJCICv/jhBATSWc0HE6E06SgAHcKDB OOx4lsmWQ4wgx413yOjGHDTABUUVqkiqwIbwkOiFnQnNZpg6OqRysLNr8IhT7GhkvXLBXY6CQhZt QhNwxMQJU9bwxPrphfgGZkYPTANC0YgQOuZ6O1yeaDm5HS470HCDcpgIG4VtB4SRaqRzJOJd29g0 ZBUH7UoSszrmSCILFHdwjWq7qwyqoSxqaMZl5MdN+9lPOAMhDvqQIqbjlcXnIyQHdsDdRKhXFIui MygMIFJRxxDCkF2W7Agv2VLjWJ5iKxrdnWmxZ8An/ONF4lU4IUtO9Amn5jjhPy2R4vlmlFNpW+6B dAgDz0KGDj+R/mp6FO3iCBpQwzyR+AVjGjjJSxCCCXJxBwA0+FET1buRqFhpLE58G+yQ1+Lxv1kx F8Ua9CMnoYB5tGJGIkcrcBAh6iAOY3ICbtI6XOABcKAHlgAI6bAIbydkpqcoPhZzaNAy7PAF53Bk FcZcX7AoukMHxsAIekNB21AK0oNtkxZZ0GVh+FdB7NAj5iAJ6TJ8XcUacgJSojEwFGMGcTInzycO VtBOEPILEvgLJWALThAAyIAGJVJIOeccyzENI6MBdrALI3NAurAEB7QoJ4gN1CAJyBAuOpILS2AO GPQthRddQpB02GUdkFQdxvAAjfN461AJgoAGXSCIXYAEg9gF/ouABpbABl3ABouABLhQiHrgiF0g CI6IBlGQCIugB4lIBV7wBqAYiqAIDaCYBncAikzgBar4BongBUSQCA3wBq/wia8Aiq9gCKHIBKSI C9IADZFQi6FYB7OYCKz4CsYoi8bYAMmoBcY4fCEhAIlDeNFoTEnkUN7Cd4mXREnEBB0iceXwCxLH DsUljrtQXMfANneyHM/hfb+kKOxgCOWGDtHwXcdgZu2EDsKwBi5QWElGDNigC7pgYEhVJFTEDhZn GdAYHdrYLtroLclmQHyXHgqZbEbCDueABLbwYydTkbtlQBVyazlGRIWUSOyQCfQxj+nAhFVjVqyE Bc6RA1BA/gzHdkDHhERCh0S80AJigAoCgAqooAyDIABiAAsbMT2TdZTsMpENeY1KmUQvgwkoEh3E QJGHhV8fUyIVwlPZkoGsl1SG0E5q1Ay9MXmWI3bNwBq0gAxN8AW6cA4FlmSL4o5IdAC1AAtTcAe8 ICVnoAzrwBDQSJGAeY0F9TIKuZCFaZgP6QjEtRybcpRItDLbApIrIzumpwvBFB1DoCUIAiJl1Qzh dDFJkxkSIJNL1Ja/NjKKAoZItQ47OQVfUQkCsBGVUAtFWZG2iZjnoJDHpJBY5pAUaZE/4ATIwAks omfQMTLbEje5dTa91hzBhHpn8wsmmTSg9V3fY1Ji0gyf/tAFToAFAZkKScYicnlUbRFmB7AKydYG pSBwv7mUTjlk3HdUD/mbTMAKzxl34sh9woAib8d9yOAxuxSC2EA3J2KSmjMwkycrcjJ5I/AN3PAD jRAATkBfSUUM/giXq2eQLtFBApB4RmIKGWWYCvkcLPKQfnWY6RkdXnAF0NEOVRABO5BEi5lX3KcJ ilIiLHKZ/TSgyJAJwxJK31ZaYfIN7/ADtyALheAEhcWFR7YouYlULKI9WvGMyXZUhzlkKNgNhwl3 pieiyfYKWLAIyeYEtdAHyUZipvdPqRCVdzdA4Jhb9NWjYsRKSOg0ZSV27+AO7vBbR3AEQuBrZ0hM cZlb/p5GF6jAkERypQ95pdzXDi2qmxZJayzKDs4wBjEXgrNjC1uTCgMZdyYCB7uQDT/mYygyBEmD OWJSPskAGuiQQt+AOZ+VIRIAnm2gC7UKl2HojAcgADVZmFW6lGaTbDwVjhDZkEqEBOyQKO1ADd2S bHhFGrbAIbnVc6ZXIruwMsZEN0iVCTR2oL3wPWo0JipECt8wAvnBCb+AAzuQCitwoRh6IprkYauA f3w3kUiUCwXlnr6ZlAbUd/LVDg5AlbqArd7Hn8fAT0emX3vma9pqJIaQDOX6ebLgmWVyJmHSC+9A rmKHDscgAcf2X3h3Du6KDdjEVetgDe25qAoZaAb0/gWLmpRaeo1KhAbJdgWDklshAqW2IAo5FZmF AAdHhQ1s06nlYAjKNyayVpaaY1LNkLG98FswEDf+WFhnuHqW4WG7yqhXaqXsoAuKqrJHqQfGxAhv sGfPwXo5tjWiECgWano31yHB9JBD8EoX+yXhlLHmijkNykb6gQ5OAAptYKHYgAPXEIZzWagkYQ1e lmzZwrX+aDZaG7kzm2y74ADgoJAnMglwsDX/2XOFcAw+ZSIj0jEk4i3EMAT94TCWQ2O98A2B4LrP NwIWoHzesAYeYAp4d2wmgHqLcrVcJQD8p42EyX3jh6KsV35gW5HScAzJNgd4Fh28xCd08wsEAgpc /vAFm8AOQYRXwot3sHC3S9MM3/ANmjM+5Aq737AM5AohSnpkyHAthkuynqYVHVqRzdWpiQQdqeCo aKuN4xi2lcIOPGCTyGkLzGkGcIAMR0BcyOAMJ9Mx51AOIxIdPipG75Afq1omDUoKp5NC79AMSYA5 sjAL//UBIPAF4JmaJDulRrMRv9meyLaB0QEFh5lPUSez4eEKyXYNm4ADaGClHLNnHpOOh8I24mlL 5eej4aQOmiMLYmdGmqOZrfYNp7OqJEwMqFALFPqPJ1iyHbSrL7youVlM/bqcpuc8IouYRHIOaLAu 8/UB86JbuzAJFbIJmjpztnaZ6TAyoLAJ3ZAJ/qhKJkS4NGb0waSQseSrRiCFBQeLCn7gBHgnhr57 EijbnjKrtVq6C8mLmB2wkObACEzgn8CxHN3ABdEJjiHSc7sAtLaEIpmgOWKHH+E0eQd6K+L7qiOA IdHgDIxMDD13bIrCTyWrFSLxl8Vkv4kKtt13mMWFqEqkw0bSVEQlfiSTc9XsT/+pAmKDo93XDUPw fJqpwclwt4HQDJ2gDq+aQgwjcgGABQAVhorSu8T8xdAYw6z3slf6vw6pr7HgM21ADcLIDiBgQAPk IZDAMfjDCS4QIjn6LO/oDa2mJbnyC7KSQoecOXMSHLsiDEkwB4vij3cnvxs6Eod6lBCZbLmg/sbM 7C1cSyR3MA4ymsXtwAh14J/HMRweolsVognYkJHaUpyGwEoXAxwIEmNzYixMY15lEifpcAG6oHrM FaViRr/sQkzHtKhWaskZ2qn4rAfssgS1IAC55QRe8JioibMe49AuoGuq2Z9KHCHF0hvzqEa90Alz GlNCHUq5JpzA/BwibbIgAbxI5bXG654vq8zI1g7S8C3XcA5OoAa7KQdeME+mwA77xdYMfaHt8Aui 42OyYAgWMCwJaizzyFZJHQ2suhkRUhzurHqpyVlGk5Dv2ZAtLbz5qa/ssAMT8AAi4NWJI3S+kAt2 UAftUFeoCUD/6X1xtwtz8ApO8AWG0EakbUA1I5B2aTZq/bEMFCMMqu0mrCEMW+C1pzABdnAOW0XP L/y1lhwdl1uYEkeRntAH7KAFeMMuSXUNO0AufcADd0ANuvMc9MSfJ1KlztEH8p2Z8/glsBQIFFND 0YAsrdQg6lTUvyABGYBUWxCjAQEAOw== ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/tfig003 R0lGODdheAAoAPcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///ywAAAAAeAAoAAAI/gD//fPG T6DBgwgTKlzIsOFBUdv6OZxIsWLCZKNIWdzIsaGhXp06ihSZSJGzkSg5KooGLKVLh7V0lXtJkyEs XQnH5QM3Lt63cfZqvryHzdi0a0avCRV6C9etW3Ju2crFjt1SlLpgwaml1Va6eFdd+nqGi5epW7yi eWsWtuO+ZsOeTYs7Td25tlfPWcP7Mp86vkLngQO88dawXqNM/cq3jvBEab72NRTsuKIuXLNOHcJF zs6eygvrORN3l6FgcqD/3QMHNqE4eu1et4PHTdy6xqn1adP275ijhM3CTTvW7l+3FMpAY7skbqG/ ffb06aOHTqC/daxaVZ7XKnm1Rwl3/tWqNevWtUYvFoGuRgudu1283h3s1gtTKF31/hpkxmsdPsLu FCLNP8UwAhw40yDjjjfM/IObY9uk0Y4//1hDoUHk4FLJKbioY45C8qwzD1/19IHNP8hg4pBeDi4U Dyn/1XSNKONko4stCPnTTz/++PNOaQrZ8wchEl0lzynZ/BONKQ7RQ8wd2ujzjzQy4JQPO3sA8Mht 9CS0TyDGWDSMOlbVsotC1XxTjj76LfQOPO3cFiNNvdxzDTzGjDKRIQAkgs06qgSQyDrw+JNNG978 4089t6nT6DAAMOHoOo7GU9A/+FjBiUGrfJLOP5aAopAutNjiTnUVhSjiS8GQss0//r/0wlBB9Fyz CmMCWbVRLagdlE87jlpzABEX/qMPP+70MmBCw0RDDTvmSLnRPbe5g9I9I06knTvjCASPtFeRE5RA 0MjBmz+tLUQPKY2MtM9t6xRpUT2E8PbNNKgm5Mo/4EBj0IN8dWPKp7JskoxCzeSjDzPJucTObflU 1E4kx/zDzCO5LCRlOGwJBLBA/XzsEjO0fIogkAcRY48509S4Dj/6RIxSPFw6NA8m3dhjTTVNbqOO ZPHAs06XAqnjTzhCVXPIXaywslA387zzITz5LOiNvCjZc9siJyYETyfd/ONOOvKZ9qo2jja4DaXr nLMOOvDC6yg+9jhq0TizfPOP/iqR1MOQPag21g8/cUr2kinNJURPHxX3kgeODNEzDTi9pvNzquHY 443cjrpTkD7pAPnMGdy8s88+1h60ijPTXK0ftge9s447fodFDyhhSgbuP27P803YFaojzTr2yEO0 RfNgLRDh64CDT5uz0MKOP8AAU6xAsejCzTbgWBN4QueEc1vZNTEz2z+oJIKQLVLdglM5SQo0Dzq+ iJxSPDL/M4o3uyPETjzzCODk/NaP4mgsbuuo3UhswYwPRSMUKFPGMYxRvX2UgxqxA4Ir0DE9ewTj QzWhhSzs9w+rsKMf96jHXegBj39wAxkVYVTcDMcReyzjGb1aiDqUYpBljMAO/sC6hjV6kC3C/CIW 8/hEMoYhj9Lggx2/0MRt7sER2cHLHRSih/IU96mGpIOHBtGVQF5hgN84xhmrKIcmsPGLdeSwH+PA TYig0aCO8OM24WhTSsT4D350g3ypUUg8QCiQdGgDXvzohSpSQsOU0GMwgVyINtBBDm8kox3g0Ee+ EuKObXSxMsDwxTRWYQtOrCIXkiFhJEtFi1ewohi7qEc2qkJLWqYDHdqYRi2rErpd0pIcvrTlRHKB C1/AAhd6eMUv9qGOaaQjHdl4pjaeGU1DUlOa10yHNZ7pM3V0cxzjUMckvanKZjQjGs+4RTqW8Y9G HkRHztni8hjiToXUAx7u/jDHOvJhDnZQMVvSCqhAaidQY8lPINIyHD8kQrT+RRIwyJgGQ3ixjTMx RBfEOJhCulGKWiRuI9xYhULg4QlfwBAh9phFK+J3EGdQIxSfNIguYgGKFoqEfQzBxi0swZBvEAIV sGBILqiRuo0IwxXXA9kwbIGLhCyjE7BoCUJU4YlS7AUhu3AEKZAmEvExZBjnmAlDyuGNjyKkH+cI hh4r4g9IIiQex2BHEWMXjqSKbR16Swg70JFXwLyDGN2wqUDEMSBz1DM1urgkPOyBj27gIkRXfehC diEOS3ziFJfIxy4gsYhwyEqyUyrHIuzQHVvQ4hSigBxoE4KMdMgiGcYwIYU+fhEMVAhvtedoxzSc wYxyRKMa2ugGO1dLkdop0CEBAQA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/cir.gif R0lGODlhCQALAPcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///yH5BAEAAP8ALAAAAAAJAAsA AAglAP8JHEhQIICDBREiNAhg4MKGBCFCdGgwIUOHExVOZLix4MCAAAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/giflibrary/12/Delta.gif R0lGODlhDAAMAPEAAAAAAP///////wAAACH5BAEAAAIAIf4mICBJbXBvcnRlZCBmcm9tIEdJRiBp bWFnZTogYi5EZWx0YS5naWYALAAAAAAMAAwAwQAAAP///////wAAAAJ2lCQiIiIihABCCCEAEEII IQACAAiCIAiCIAgAIAiCIAiCAAiCAACCIBAAAAKBQCAQAAACgUAgEAAAAoFAIBAIBAKAAAAQCAQC gUAAEAgEAIBAIBAIAACBQCAAAAQCgQAgICAgICAAICAgAAAAAAAAAAAAACBQAAA7 ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/tfig004 R0lGODdheABVAPcAAAgICDlaIHNzaoODarSkILRaQZS9GP///4usSkFiYjlzizl7rKRzcylBYila i0pig1IYGFKUnJRSUiApOb3FxZTFWmqDe0FzlJRaMUqUtNW0CFqDGGqcIJS0WqRqCClBUjFaYnOc pKyLUpSLGHvF3lJ7c4uLg3O9lMXVpEGLpGKLIEFaEKxaEKSLc3OUant7c2qDEFJzEM3NpFJaCKyk GGIYGKRiSntSOb3Ne0pqe6yknJycWlJSUsW9rFqLant7OTFai1qcnDFBYqR7StUAIL29izk5OYO0 c3t7e2JiYqycnLS0rEp7nFpaUmpqYtXNSkFBQVpiEDFzpGKUgyk5SkFilMXFvZSkIFJSSnuUEDk5 MUGDnIO0GIODg829e3NqantzaqS0MWJiWkpaYtVaEGIgGGJialKkvcWkMYODe0E5OXNqYnNzczla UmqLc0oYGGpiYs3FxZSLi2JaUlpSSkFBOZRzMWpiWjExMZyUi2paWmqLlDFinGpiakFBUpyLi5yc nHt7gykpKc3VtJycpIO9ezkQEJyLUlJKSjExKYuLi1pSUmpqajlSEEpKQVJzlIucrHODlDk5Qebe 3pSUlEpKSrSspP/FCIuLlKykpIuDg5yUlIN7cykpIEpBQRAQEMW9vWJaWouUYpSUiykxQayspGqc e1paWouDe6SkpGp7nItzaqSknL20rMW9tCkpMYNaSikYGN7e3lJSWrS0tLS0vUE5QZSLlCAgIN7e 1aTFzZSLgyAgGM3e1aScnIuDiyAgKYODi6ysrMXFxcW9xc3NzdXNzdXV1TkxMcXV3kpSYmJqezEp KaTFe729vZyktJSUnL29tLSkpKSclL29xc3Nxebm5hgYEIN7e8UYGLSsg83FvVJig4uUpCkgIHtz c97V1b20tBgYGObm7vb29vb27sV7EDlKYubm3vb2/6SkrO7u5iAYGLTN1dXVzXNqcxgQEPbu7ilK Ys3Fzb2UIO7u7r3NxSBBYmqsve7m5rRKIN7e5rSsrP//9v/29jmDpCwAAAAAeABVAAAI/gCtAbJ2 oKDBgweW1EsVTpasesciDjNmbVixetaK+bMm8EAxYejAHXN4zFo9hChTqlzJsqVLhMJ80Trgj6bN mjVp8XMmDFCmA86WaFpSawm2aMKEberFT5izA+Fo/aKlU1OpVJMO9MN5syvXr17Dgh0rtizYA2y6 HCtILmW9erImySpmrd+kSb3kRixpTVY8jgT7oqN7TNgxYgXTvVzMuHHLtm/J1TzQtjK5t5gza96M OR9nzOvqkeuXjrTp0qhPq07NerXr1rBfq7ZpsG3BybcP/KVpLetXWTjBHQCem5ws3sbW0ibL3Kzz 5tDDKs492Xbb6rRS0XLGEKEsQMOE/g1z1tGgv2GAtoNz9rRm6YMnHcufj7Af5dpsl+f3pahpsWIH KKZYMYA4JZ41wtjUVipyaHcMKMPYRtp9iihiTWX3Yahhhhxu6GGHIH7YlmL2VYcfZc6AQgGEzrBC DHvOVCOLM1YQYwU/tMQxDCjsAQYYKByh01c8BZFWDyAA3lfTdUo2yeSTCka5pJROUkkibfdFSZk1 n4gDjzjsIGMEL1/CA0UXYLKDiydjzMKMOHDK4SWYddiCy5zipBKgQakMgxt9gLpU4p65ZUmbNWCK 4w0cu2jCw53iOKKJmovuUYANY3iDCzty8sKOESWsAoskcLKj51ZamShiiKyu6iqI/u+1ZV9+WpKT D5i4NOELIVNYgAw74niiiDeCaIGJKERkY4ERmlKCC7HnMEAEERJsistPidGqX3TcPuftdO7RZluW iPLCjCau1CLKFJ54I04ligjCTCjGhKCJCZF4Iog3zhI7iwjT6gPMpgnKmo4VqUz5Z6AMG2SfhCcy SVM97CACRybGyFILIYt4ww68yGDjjmL7hLeIJshQQqwavzAhyhBTSKKpnrQNgwShreb86s6wDgpu oeQKsssmlhjjTjHbbFLHx3LI0RdH4MQRjTS7CKIyHnKI9Awk3fCzyLU2lVaML6NlOeGECleZNpRr U8k2obIWxFExshzjzDHF0GKN/jdpYLNJHNuEY0km2OACLzZ5yLGNMXFYsokO3/DrjSe5WBEHOMT4 kokveGCrVT3G0ILTQ4oRtHDD8j1cqD/CZAdIVKmkQkk+eHDyRSbVgLLEN6iAUbEidSAiRzW5FNPK C9h80QklnSwCyibGFBPOL3Bgw0yCqAGljm3HoHNAOce95ZlJ41szfj3np4/ROpNghL776pu0DmtZ /gk1R7nUAw5HiGgyjSvGsEI4UIEIRBjOBN5YRNEmwTg5wAEOkluEDuKgPysoIRRQYMapbuMMQIxI FtaoyXH0c5+TWGd1+fFHfCZjovqdhCuDCtCsEIIba9ThG3AQQxJCEQoshOIU/u/6hRFOAQUxGUEL dQiFGMThrEUkwRF+qIMREgGHUIjjJwI6wDFMUJMZpiMXLbSNClGYpXGlQzS0EmOh1nGQLJomhVkq jT/GEYpAyEMBJYhBDGBAABbUoBImUEQkgIAPU3CAA2HQABlqQAk1DOMeGQjBIa+gAXPUwBJayWQc atGWY/hjEoGRoSjfgwgPkuOUp0wjTRhRB3+ksoxpPEZqbDIhEsbxe+qgwDPakQwU4AAFT0ADAzYR Dkps4hm9sEYvBuGFIrSAE6DAhjoIkYxeLNMK2hABAwDkHms4gx/92McSjpEKZ5BDOKMcVBJSEY/L tDOE2joAEipxGdOpkjLF/tAC+uZnHxLhpoVd3MiXuiSOToAJHrGAhx9+AaeGeqMTHmMHpxoqjn1d 46JwosaetkKVdJAjE/vg0QHgiSosmYctJiwOQuKjRtoYQxhtyUd+ajmdE5KLonhQhiQkCqdKBENN 7ABGJ8aQg1d4Shy3wJU3xpAAQfBUHE8pqSzK5rB0jHA6NeXQfQBxkpI2qRjfGGEYT1qPn4lSS5Mp XUOZwQg+8CEUwABTJX6hpmcBoRAGYMLA2EEJXuACF+c4QjYQMAGggsIgihkGG7him6wYTHW4sU0x AJAJzNSvIIAAwEzGSpt0rKMcaY3hSe+zFUSpyROBeEQgsOENYHwME96I/i0eFlCIQmSACs2KrSAe YYAwFOIcA8PFYd9znlRcZiDCAM4IS4obOeZGOWMU1wEwQhBYdtY+vsAEGr0KokOpia3SIEbmKqEp RCgCF/KqRBBEQA98NCC3gkCGD7hgDnpsgRmeokA/5TYTBMkCR+SoC1bzY8aDTAaNhpoYQGeqGECM YrqhNWtnR8oOKCCOH6AARTimgQ1kwItY31BHBMhQAHxwAxneGAUumJGHLdCDCGQIghmQIVxakiN6 WvEMGqvbxfeo9DRaUccpCoWhlEp3o7kZR2JmuJFiOGMYx7BIP4xRD0GgAhua0EErlqCDTeShgMPS Aj/C8YgUREABvpCD/tWYUYdMVKECzTjBFpSwiUQgZk/kGAY/cMabWqpxXGq0TyoWgZnj4EamR5ZV uArCz64cIEFUWYeTgbK3L4QCDtOQRibysAhEQMG83kgCNjgRjucF4xvYsJo3+hCOQFRhAUAYwyLY wIzDqu4YvtBNKeACoOq2VDFpw7PDonudlL6HuFU1kknx6eSNgKMYec4HLyrBKB2UQhqbWIMnDKcJ XKhhEX+oxjzi4ItQICJlgqBDJoqxD2qE4xvMINZTiOsMWoSTFseISoBZONNs9VtLd8vNVDPJbxn6 8wDrMNF0TDoZawhiEaFwwjcmLoAqvguBdWjCF0ygiS58QQAGrHMo/pzIiCR0uhJQYMdhaQMO42rx JAQx8gnf80b3eLEfuAgFZo4BgJuF9qyLRvSV9GOb0uQjFMv4AAja0IhGROEQGDCEeY2ACSHIIwEB WMEMRuCBMkAjFJGQRwossIENjIAe+oiFrffUi00UPMBELpKjrzTL4aR0EmwQhsL7eTabnCR7Lez3 OBixjAfg4wgIQAAB0MACCEgKCpiQBz7aUYEOaIMGXYcGFBahinbYoxmsgMENyuCNaIjSGreAaTqG 4ZHjyNRgqcKZokVJluna3sfM9Xc9WG+fWhI4N+nwx3/AkY/i52MfvTBGNUryH2PcZRLoKF4x5jGJ WoSD+PFYBzi2/rGE7tdFhhshyCTwHY8IZWWjoQ2X75vr72NgwRqizk8WSVuaYFSiHkr+J3WWbI0v eQkZnoAH7AAPnwAPeIAmPOVtX6AGEsVXgiAInQBR8hKBuNAJh6V/p0QL6OAMx0EQMTR0yBZHptFj /TAMeGAMWJAEcOGBsWcosiAcCSd3CRY3iAInyBAIC3ABdgIneIBAxCIIiLAMZ2AGeDAwlAAswAIM QqAMdwIsT2FwNHQb6KAYJzQhRXdPiJVJKOEZi6ZG1REfZoUhe2JauPAFtxABYfAAmyIOyDAs8oIM mtANFxAJiBBb/YJeQtABO0AFnsIOGhVDTDJwB3B+l0UbqkN0/qQFFumQD5SgCJ5UiLRiDKRFKybS D6ZlBHIQDpgQActAY2wYL8gQCoAACvkwDl7zCpJDLMjwAKZgCuegKbjQHktGG9vhSsfxa3wXghJS cAunFdAAAAAACKMlhqckCIa2f5eFKMxwB9NQDNTwAOoQCszADnigCGrACsawP+SwD8agCaGgaoKg Bt9QDBSgCrS2KSt3bPlBC5I4HO3UTuUgGvFIDuXwjqckj6KRj/e4j5FRDsUQB+igj/p4GaeEIMfQ TpXxFiZxGfWgQogSCpogB6BQDMQACr6gCXjQhncQDpnQCrkwDtYADoKzCMwjQVRWCw6ACe/wV1FF ewhBhfWg/gioFJOiQQ7xoAiRMZOoRA5ntI8EaZM+WZM1iZD1UA5AWZMFQQnhIT1BMQ7CkA/sAAeo 5goaNg1XZgRtiAzBMzzgYAylkAe+0ASbAAVKwA/uYA3HgAnqoAmJoHIuySFdNF0zESDkEA4H4Qwp tWhL0g+A9k9i6ErLIRnSNRnDsAk9sQRUIQtPiQvYAAZ/IECtgAqeoAbIUI2dwAwXYzTk5gTYgAiN 5AkCwA/gMA/8gA3fYAu8oFHXVSjAxh41MxPAhphPKAvV0AXcAwi+YDqhgw17wh16Rxm+4JqnpB1P WA+ZAAjHGEMNpwVX1gpxEAfhMAqh8FdtGFvfEA3mAw6t/oANa5Ay3oAHfwAOuRAH/MAIiOAIbmmF qjQr9ZYf1rB2B7AddjldwzAM8ORkqYBoUDYT9lEMcpAg05WfFFAQ4PA67XEMyJkkI5ItNeFwX5AE UOAIUOAJRvAFiNAJ1agGQNRQvGAEWIAIfOVtmgAIqbAJXTAHPKAG4nBnuaeOljEZ/UAkBodGpWGT MupOGHIhTJKX6RCP4jIulCGjMBqXAZIPlaAO97AFQaACKpAFBGAOZYAMuzAMqrAAJFAIXMAFT3AJ ZAABKkMJVod1TjcCNvAGpld0s9J3f8IkIUhCPsZwhMIVBCd/s3EQC2pw/VAPcKAO3dAOy+RLOzAE GNAH/pmQBGZACBeCDtVQBHlwB4vAD2JwDKpAAu2AA82AA09ADxKQJC4KfGh1ItZ1WZOwIYcof7M4 pEsWfLnxRimBE6dzEL03Qw4Tq3/Cb6gydHsSWXBUUr+WHcUwDO7QhWaTiKZqNs+QCyQCbE0ip/vH WFBYe+PSXPtVJFQ4idnje1jFd6KUCbFznMgIZCU1HdqKE0MhjFqojlnYi22kFUM3rS55FrFCQn13 WY/1c5HVG9TKrsiYrDV3EIrwX8KGKkB2UlmUrLF3rbO0MFmFJSeUfv32JyHoXHQKfuvqe9elGJkw l7yohWJ4cJBoq6yZq9lyq2ejq+HqbxgSrjdHKzcX/q9agnvYwXojAlnA94E2KyD7lVZzimR/orLK in7sOivhcmz9arB/KbJNop4HgSMHwA9WoBOUIAzgwJNpaq+zmEkCW4kDdqu/h2SZZLCXJa6nOrK2 BKOZBKS/dh9BARTOUAvR0AW0IFaEgq5EO3/ZulEuq68Hm4urKaewN3uitKANa6r8anNnpRWb8BQh 9BbT5RtdS4K2arheSIl4i62iBbiUO3ctyLF26pLc9ZY1QQhWoH8bwbKrOYtiW3CZi7nOFWF6S4yH C7bZ82fIiKYSq65R4W9yczY/O7j0Bze/pyrwNImIVbWou7mz1FJuyl3q6FVxMyXCoA5nW0Kx93O6 /riq1gVoS/Z3NUu0Vuu8c9q7TUK8s+Sx1ZpgjzZvZxkOxTASMrqwchqxiEgl/YAJvHBPU7In8jtK hpi5sOS9LTh0BVcTrFAM/VlvDIFO13u8xGooF2KnbxE6n3pSvfdzsHeyNmVdzDq3+mpT4BIOe+YP spAPw+AQLPhzv9uvhGIazPAUDCmjcKpV5wu2uOhoR7um9HeIXBuXbaEItZASx3G3hru/sBeP7CAM 9UAkfAuuPzN7RDt37lqI2ju5+iG2hrIQZxol+TAotTSus3iF8RgP9cAIrHcfPva+2hqtBgY06aRV aKot2YO62lp3NpEjFStT52u4VmsTYZzEa3yw/lOonKnatSc0s4YosWNlthfssVyxcL4AIJXBPj25 sxKDrjMpxjB8uwZRDIgQd2azwAt3s8X7lvF6cLy4sguiseRQb85gDJW8ssjGCIzgTqOsKm8haRHT rP4WUGb8lm+8xz2WhfwbN3ySaw8TDs5AN6Ncvg+DGTxwCmb0gZThx/zmsUAauP52JTZLS3u8sDks SjlLE3lTDYumFfBkU0sixvlgEklMI1RyAEoWGV4kd1cYJVeIKk4MSzrLv9gcNvrKyx47Wv9cXYGJ Ee3DuMubGOTwAgYcNm+0oAK7sJgrgvHksshWS4osd9laqweQsRTboKkBFyCEYECTDoWRKmdU/pSp IIlZlXs0dYj7fMPSJTGAW9Nx2s/ZsnD4prvp4AS0AH37EB8qVYlHWZRAo8Lw24KVqLMWO75efNNn JdNJmx/8sBYGkyC4YAKZERqfsXO0gGCLpsm/O2F4m9MxNBtGO2FvZLC6WrwOO1LR8ISTYXqESBZC axMMEsCiFYJvF7SX1XtZZSKq+8Wras2/NyHo6kq3UApl1JDHKNA/S0bXe88tLcSqxMvxNLgSw9R7 zLWiZRCsAKDIVl1x7Fy5OCsLa7BczK+V27fZTLnorIWwdLJ+tsLXhRNOxnrMegyzhw64MQ6vpJ4l 69eWzc2suc3BPIMhiyH7DLZ97c0G4QsA/pqqcqARBVEPfZAfr+PUGzvcKju3Ty2/vCrFeosfD+3J gcbaATYeS2KfvfEQ7uM+62AS7HzQ5IN/7Fzf4oN/bzEOCokZ4T2tgItsLXRwzI3emcvIBeEMXVDG 8RkO9QAggKgf502ssEe8RKrHckzWbTrbKIy/qxvA5pHEKTUPsrAOxOHNzRuGJ5Xh/CvYG77U2Vzh VnvgGkwrd3vNG8sR+rrW9oERjxi2BXERQW7abDEM893G3czF/my9ZBviHn61TU6t9rEd2xJ79VBv Mku2bWENcBu7GdI68xmx03q9VnzBAI02UG61ZlusB6AjFZ0Y5bcEPPbPBcEPw6Cxvvxkerq9mhe9 sKrjXObrb7PSUjWssFqFz3H3WGu8ytNnDaERhR3svzE+Uwq3s3pNrIL+1Bcex15VzrxbsxTbm/2A BLFzi9LlY32NIWR+ulzby84t5fwc2xXs0FdytP1bzb0nCxQhUo0syDfee34+tjkud7nnkqlBguQ9 HQEBADs= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-BOTTOM: 0px; BACKGROUND-COLOR: #fff; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; COLOR: #333; PADDING-TOP: 0px } H1 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H2 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H3 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H4 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H5 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H6 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #f90; = PADDING-TOP: 0px } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } LI { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } DT { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } DD { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } .txt { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } FIELDSET { BORDER-BOTTOM-STYLE: none !important; PADDING-BOTTOM: 0px !important; = BORDER-RIGHT-STYLE: none !important; MARGIN: 0px; PADDING-LEFT: 0px = !important; PADDING-RIGHT: 0px !important; BORDER-TOP-STYLE: none = !important; BORDER-LEFT-STYLE: none !important; PADDING-TOP: 0px = !important } LEGEND { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-BOTTOM: 0px; MARGIN: 0.25em 0px 0.25em 1.25em; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } DL { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DT { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DD { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment LI { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment LI { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment DD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment DD { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } .homepageFragment H1 { COLOR: #f90; FONT-SIZE: 20px; FONT-WEIGHT: bold } .homepageFragment H2 { COLOR: #f90; FONT-SIZE: 18px; FONT-WEIGHT: bold } .homepageFragment H3 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H4 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H5 { COLOR: #f90; FONT-SIZE: 14px; FONT-WEIGHT: bold } .homepageFragment H6 { COLOR: #f90; FONT-SIZE: 12px; FONT-WEIGHT: bold } .homepageFragment H1 { COLOR: #f90; FONT-SIZE: 20px; FONT-WEIGHT: bold } .homepageFragment H2 { COLOR: #f90; FONT-SIZE: 18px; FONT-WEIGHT: bold } .homepageFragment H3 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H4 { COLOR: #f90; FONT-SIZE: 16px; FONT-WEIGHT: bold } .homepageFragment H5 { COLOR: #f90; FONT-SIZE: 14px; FONT-WEIGHT: bold } .homepageFragment H6 { COLOR: #f90; FONT-SIZE: 12px; FONT-WEIGHT: bold } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, sans-serif; = FONT-SIZE: 11px } .homepageFragment ADDRESS { FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, sans-serif; = FONT-SIZE: 11px } TABLE.menuIEFOUR { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; BACKGROUND-COLOR: #13709d; MARGIN: 0px; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: left top } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .menuIEFOURSIDE { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .menuIEFOURDOWN { BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } TABLE.menuIEFOUR TD { PADDING-BOTTOM: 0.2em; FONT-SIZE: 70%; FONT-WEIGHT: bold; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; COLOR: white; FONT-WEIGHT: normal; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { TEXT-TRANSFORM: uppercase; FONT-STYLE: normal; COLOR: #6089b2; = FONT-SIZE: 0.7em; FONT-WEIGHT: bold } H3.navigationHeader EM { FONT-STYLE: normal; COLOR: #ff9b06; FONT-SIZE: 1.1em } .homepageFragment .mostAccessed { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .homepageFragment .mostAccessed { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 1.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-BOTTOM: 0px; MARGIN: 0.25em; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif; COLOR: #ff9900; = FONT-SIZE: 11px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-BOTTOM: 0px; MARGIN: 0.25em; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif; COLOR: #ff9900; = FONT-SIZE: 11px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI DIV { COLOR: #000000; FONT-SIZE: 100%; FONT-WEIGHT: normal } .homepageFragment .mostAccessed LI DIV { COLOR: #000000; FONT-SIZE: 100%; FONT-WEIGHT: normal } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } DIV.banner TABLE TD A { DISPLAY: block } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-COLOR: #13709d; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-POSITION: left top } UL.menuDOM LI { BACKGROUND-IMAGE: none; PADDING-BOTTOM: 0.2em; DISPLAY: block; FLOAT: = left; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { PADDING-BOTTOM: 0px; DISPLAY: block; BACKGROUND: white; COLOR: white; = FONT-SIZE: 100%; FONT-WEIGHT: bold; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuDOM LI UL { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuIEMAC { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } UL.menuDOM A { PADDING-BOTTOM: 0.1em; PADDING-LEFT: 0.1em; PADDING-RIGHT: 0.1em; = DISPLAY: block; COLOR: #90d7ff; FONT-WEIGHT: bold; PADDING-TOP: 0.1em } .hideNSFOUR LI A { WHITE-SPACE: normal } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } LI.nosaved EM { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 180px; PADDING-RIGHT: = 10px; DISPLAY: block; COLOR: #336699; TEXT-DECORATION: underline; = PADDING-TOP: 5px; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1em; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: left center } UL.menuIEMAC A.menuSideArrow { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1em; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: left center } UL.menuDOM LI UL { POSITION: absolute; TOP: 2.25em; LEFT: -999em } UL.menuDOM LI.menuhover UL { Z-INDEX: 999; BORDER-BOTTOM: #90d7ff 1px solid; BORDER-LEFT: #90d7ff = 1px solid; WIDTH: 200px; DISPLAY: block; BACKGROUND: white; MARGIN-LEFT: = -1.25em; BORDER-TOP: #90d7ff 1px solid; TOP: auto; BORDER-RIGHT: #90d7ff = 1px solid; LEFT: auto; voice-family: inherit } UL.menuDOM LI IFRAME { POSITION: absolute; TOP: 2.25em; LEFT: -999em } UL.menuDOM LI.menuhover IFRAME { Z-INDEX: 998; WIDTH: 202px; MARGIN-LEFT: -1.25em; TOP: auto; LEFT: auto } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-BOTTOM: 5px; MARGIN-TOP: 0px !important; PADDING-LEFT: 5px; = WIDTH: 190px; PADDING-RIGHT: 5px; DISPLAY: block; BACKGROUND: #ff9900; = COLOR: white !important; FONT-WEIGHT: bold; PADDING-TOP: 5px; = voice-family: inherit } LI.nosaved EM { COLOR: black !important; FONT-WEIGHT: normal !important; = TEXT-DECORATION: none !important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none !important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif) = !important; MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1.25em; = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } .domArrowOut { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) = !important; MARGIN: 0px 1em 0px 0px; PADDING-LEFT: 1.25em; = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left center } UL.menuIEMAC A { PADDING-BOTTOM: 0.1em; PADDING-LEFT: 0.1em; PADDING-RIGHT: 0.1em; = COLOR: #90d7ff; FONT-WEIGHT: bold; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { PADDING-BOTTOM: 3px; DISPLAY: inline } UL.menuIEMAC LI UL { POSITION: absolute; LEFT: -999em } UL.menuIEMAC { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif) = !important; PADDING-BOTTOM: 0.1em; BACKGROUND-COLOR: #13709d; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: left top } #user { BACKGROUND-IMAGE: none; PADDING-LEFT: 5em; PADDING-RIGHT: 2em; COLOR: = white } #mycart { BACKGROUND-IMAGE: none; PADDING-LEFT: 5em; COLOR: white } #menu { BORDER-BOTTOM: transparent 1px solid; BORDER-LEFT: transparent 1px = solid; BORDER-TOP: transparent 1px solid; BORDER-RIGHT: transparent 1px = solid } .hideNSFOUR LI A { WHITE-SPACE: normal } .hideNSFOUR LI { WHITE-SPACE: normal } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.standards.css @import url( /freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { MARGIN: 0.25em 0em; PADDING-LEFT: 1em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: url(/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-IMAGE: url(/images/bg.basic.gif); BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 100% 100% } #searchBox { BACKGROUND-IMAGE: url(/images/bg.search.gif); BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 0% 100% } #citationBox { BACKGROUND-IMAGE: url(/images/bg.citation-finder.gif); = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: 0% 0% } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-BOTTOM: 2px; TEXT-INDENT: -16px; MARGIN: 0px; PADDING-LEFT: = 22px; PADDING-RIGHT: 3px; COLOR: #666; FONT-WEIGHT: bold; PADDING-TOP: = 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-BOTTOM: 2px; TEXT-INDENT: -16px; MARGIN: 0px; PADDING-LEFT: = 22px; PADDING-RIGHT: 3px; COLOR: #666; FONT-WEIGHT: bold; PADDING-TOP: = 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .dataTable TH { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { TEXT-ALIGN: right; MARGIN: 0px; FONT-WEIGHT: bold } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { BORDER-BOTTOM: #ccc 2px solid; COLOR: #f90 } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { TEXT-ALIGN: left; FONT-WEIGHT: normal } #contentFrame .mainCol #footer { MARGIN: 10px 10px 0px; BORDER-TOP: #ccc 2px solid; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { MARGIN-BOTTOM: 0px; COLOR: #666; FONT-SIZE: 70% } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { BORDER-LEFT: #ccc 1px solid; PADDING-BOTTOM: 7px; MARGIN: 0px 0px 15px; = PADDING-LEFT: 10px; PADDING-RIGHT: 10px; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { BORDER-LEFT: medium none; PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; = PADDING-RIGHT: 10px; MARGIN-BOTTOM: 0px; PADDING-TOP: 10px } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { BORDER-BOTTOM: #cce5ff 1px solid; MARGIN-TOP: 1px } #contentFrame .sideCol #citationBox .item { PADDING-BOTTOM: 10px; MARGIN: 0px 10px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { MARGIN-BOTTOM: 0px; COLOR: #666; FONT-SIZE: 70% } #contentFrame .sideCol #relatedProducts UL { PADDING-BOTTOM: 8px; MARGIN-TOP: 0px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { TEXT-ALIGN: right; PADDING-RIGHT: 0.5em } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { COLOR: #9cf; FONT-WEIGHT: bold; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-IMAGE: url(/images/fill.personal-nav.gif); WIDTH: 100%; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-POSITION: right top } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = WHITE-SPACE: nowrap; PADDING-TOP: 0px } #personalnavSpecial { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-WEIGHT: bold; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.5em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-BOTTOM: #069 2px solid; BORDER-LEFT: #069 2px solid; = PADDING-BOTTOM: 2px; PADDING-LEFT: 2px; PADDING-RIGHT: 2px; FONT-FAMILY: = arial; FONT-SIZE: 11pt; BORDER-TOP: #069 2px solid; BORDER-RIGHT: #069 = 2px solid; PADDING-TOP: 2px } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { TEXT-ALIGN: center; LINE-HEIGHT: 140% } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: url(/images/bg.logo.home.jpg); BACKGROUND-COLOR: = #001941; BACKGROUND-REPEAT: no-repeat } #logoCell { BACKGROUND-IMAGE: url(/images/bg.logo.jpg); BACKGROUND-REPEAT: = no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; COLOR: #666; FONT-WEIGHT: bold } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-BOTTOM: red 1px solid; BORDER-LEFT: red 1px solid; = BACKGROUND-COLOR: #fcc; BORDER-TOP: red 1px solid; BORDER-RIGHT: red 1px = solid } #browserWarning { BORDER-BOTTOM: #c00 1px solid; BORDER-LEFT: #c00 1px solid; = PADDING-BOTTOM: 0.3em; BACKGROUND-COLOR: #fef; MARGIN: 5px 28px; = PADDING-LEFT: 0.3em; PADDING-RIGHT: 0.3em; FONT-FAMILY: arial; COLOR: = #300; FONT-SIZE: 100%; BORDER-TOP: #c00 1px solid; BORDER-RIGHT: #c00 = 1px solid; PADDING-TOP: 0.3em } .invisible { POSITION: absolute; WIDTH: 0px; HEIGHT: 0px; OVERFLOW: hidden } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { MARGIN: 10px; FLOAT: left } .linkPrint { MARGIN: 10px 20px 0px 0px; FLOAT: right } .linkTop { TEXT-ALIGN: right; CLEAR: both } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { COLOR: #c00; FONT-WEIGHT: bold } #errorList LI { LIST-STYLE-TYPE: none; COLOR: #c00 !important; FONT-WEIGHT: bold } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 0px !important } #contentFrame #intro .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { BORDER-LEFT: #ccc 1px solid; PADDING-BOTTOM: 6px; MARGIN: 10px 0px; = PADDING-LEFT: 8px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { COLOR: #369; FONT-SIZE: 80% } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { TEXT-INDENT: -2em; MARGIN: 0px; PADDING-LEFT: 2em; COLOR: #666 } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { LINE-HEIGHT: 150%; MARGIN-TOP: 8px; COLOR: #000; BORDER-TOP: #ccc 1px = solid; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalReferences .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalArticleMain .mainCol #content { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 16px !important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { TEXT-ALIGN: center; MARGIN: 0px } #contentFrame #content .issueNav SPAN { COLOR: #f90; FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-FAMILY: geneva, arial, helvetica, sans-serif; COLOR: #333; = FONT-SIZE: 70% } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { BORDER-BOTTOM: #ccc 1px solid; PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px = 0.5em; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px = solid; PADDING-TOP: 0.5em } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-BOTTOM: 10px; PADDING-LEFT: 6px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none !important } .journalArticleMain #intro .item { PADDING-BOTTOM: 0px !important; PADDING-LEFT: 0px !important; = PADDING-RIGHT: 0px !important; PADDING-TOP: 0px !important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px !important; PADDING-TOP: 10px !important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px !important } .journalArticleMain #searchBox { WIDTH: 150px; BORDER-RIGHT: #99c2d6 1px solid } .journalArticleMain #intro #searchBox .item { PADDING-BOTTOM: 10px !important; PADDING-LEFT: 10px !important; = PADDING-RIGHT: 10px !important; PADDING-TOP: 10px !important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px !important; PADDING-TOP: 0px !important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = BACKGROUND: #565565; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { COLOR: #369; FONT-SIZE: 80% } #contentFrame #content .prerendered { FONT-FAMILY: arial, helvetica, sans-serif; COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered TABLE { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { BACKGROUND-COLOR: #fff; COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered TH { BACKGROUND-COLOR: #fff; COLOR: #333; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { COLOR: #333; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT A { COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered FONT[size=3D'+1'] { COLOR: #666; FONT-SIZE: 12px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-SIZE: 14px; FONT-WEIGHT: bold } #contentFrame #content .prerendered FONT[size=3D'4'] A { COLOR: #090; FONT-SIZE: 14px } #contentFrame #content .prerendered P { COLOR: #333; FONT-SIZE: 12px } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-FAMILY: arial, helvetica, sans-serif; COLOR: #333; FONT-SIZE: 12px } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-SIZE: 140%; FONT-WEIGHT: bold } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { TEXT-TRANSFORM: uppercase; DISPLAY: block; COLOR: #f90; FONT-SIZE: = 110%; FONT-WEIGHT: bold } .prerendered .firstLevelHeading { DISPLAY: block; COLOR: #369; FONT-SIZE: 11pt; FONT-WEIGHT: bold } .prerendered .secondLevelHeading { DISPLAY: block; COLOR: #369; FONT-SIZE: 11pt } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { COLOR: #369; FONT-SIZE: 10pt } .prerendered .referenceNum { COLOR: #369; FONT-SIZE: 10pt } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-FAMILY: arial, helvetica, sans-serif; FONT-SIZE: 11px } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/bpg.css .prerendered .invisible-anchor { DISPLAY: none } .prerendered A { COLOR: #336699; TEXT-DECORATION: none } .prerendered .body-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .appendix-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .toc-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .article { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .doi-title { MARGIN-BOTTOM: 6pt } .prerendered .articletext { TEXT-TRANSFORM: uppercase; MARGIN-TOP: 12pt; MARGIN-BOTTOM: 0.4em; = COLOR: #333333; FONT-SIZE: 12px; FONT-WEIGHT: bold } .prerendered P.para { MARGIN-TOP: 0em } .prerendered .titlegroup { MARGIN-BOTTOM: 12pt } .prerendered .title-document { DISPLAY: block; FONT-SIZE: 140%; FONT-WEIGHT: bold } .prerendered .title-surtitle { COLOR: #666666; FONT-SIZE: 100%; FONT-WEIGHT: bold } .prerendered .title-subtitle { COLOR: #666666; FONT-SIZE: 100%; FONT-WEIGHT: bold } .prerendered .correspondence-label { =09 } .prerendered P.reference-list-para { PADDING-BOTTOM: 0px; LINE-HEIGHT: 150%; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; VERTICAL-ALIGN: middle; PADDING-TOP: 0px } .prerendered .clear-both { LINE-HEIGHT: 0px; HEIGHT: 0px; CLEAR: both } .prerendered UL.references-list { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.references-list { CLEAR: both } .prerendered UL.references-list LI { CLEAR: both } .prerendered UL.references-list SPAN.reference-list-label { WIDTH: 3%; FLOAT: left } .prerendered UL.references-list P.reference-list-para { MARGIN: 0px; WIDTH: 97%; FLOAT: left } .prerendered UL.toc-list LI { FONT-SIZE: 100% } .prerendered UL.references-list LI { FONT-SIZE: 100% } .prerendered UL.listlevel1 LI { LINE-HEIGHT: 120%; FONT-SIZE: 100% } .prerendered UL.listlevel2 LI { FONT-SIZE: 100% } .prerendered UL.listlevel3 LI { FONT-SIZE: 100% } .prerendered UL.listlevel4 LI { FONT-SIZE: 100% } .prerendered UL.listlevel5 LI { FONT-SIZE: 100% } .prerendered UL.listlevel6 LI { FONT-SIZE: 100% } .prerendered UL LI { FONT-SIZE: 100% } .prerendered P.list-para { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 10px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel1 { MARGIN-BOTTOM: 12pt } .prerendered UL.listlevel1 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel2 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel3 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel4 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel5 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel6 { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .prerendered UL.listlevel1 { CLEAR: both } .prerendered UL.listlevel2 { CLEAR: both } .prerendered UL.listlevel3 { CLEAR: both } .prerendered UL.listlevel4 { CLEAR: both } .prerendered UL.listlevel5 { CLEAR: both } .prerendered UL.listlevel6 { CLEAR: both } .prerendered UL.listlevel1 LI { CLEAR: both } .prerendered UL.listlevel2 LI { CLEAR: both } .prerendered UL.listlevel3 LI { CLEAR: both } .prerendered UL.listlevel4 LI { CLEAR: both } .prerendered UL.listlevel5 LI { CLEAR: both } .prerendered UL.listlevel6 LI { CLEAR: both } .prerendered UL.listlevel1 SPAN.list-label { LINE-HEIGHT: 150%; WIDTH: 5%; FLOAT: left } .prerendered UL.listlevel1 P.list-para { LINE-HEIGHT: 150%; MARGIN: 0px; WIDTH: 95%; FLOAT: left } .prerendered UL.listlevel2 { MARGIN: 0px 0px 10px 5%; CLEAR: both } .prerendered UL.listlevel2 { MARGIN: 0px 0px 10px 5%; CLEAR: both } .prerendered UL.listlevel3 { MARGIN: 0px 0px 20px 5% } .prerendered UL.listlevel3 SPAN.list-label { WIDTH: 5%; FLOAT: left } .prerendered UL.listlevel3 P.list-para { WIDTH: 95%; FLOAT: left } .prerendered UL.listlevel4 { MARGIN: 0px 0px 30px 5%; CLEAR: both } .prerendered UL.listlevel5 { MARGIN: 0px 0px 40px 5% } .prerendered UL.listlevel6 { MARGIN: 0px 0px 50px 5% } .prerendered UL.listlevel2 SPAN.list-label { WIDTH: 5%; FLOAT: left } .prerendered UL.listlevel2 P.list-para { WIDTH: 95%; FLOAT: left } .prerendered .table { TEXT-ALIGN: center; MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt } .prerendered .table-title { FONT-WEIGHT: bold } .prerendered H1 { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 0.4em; COLOR: #336699; FONT-SIZE: = 1.1em; FONT-WEIGHT: bold } .prerendered H1 .abstract-title { MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; FONT-SIZE: 1.1em; FONT-WEIGHT: = bold } .prerendered H1 .abstract-title-with-preceding-heading { MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; FONT-SIZE: 1.1em; FONT-WEIGHT: = bold } .prerendered H2 { MARGIN-TOP: 0.4em; MARGIN-BOTTOM: 0em; COLOR: #336699; FONT-SIZE: 1em; = FONT-WEIGHT: bold } .prerendered H3 { FONT-STYLE: italic; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; COLOR: = #336699; FONT-SIZE: 1em; FONT-WEIGHT: bold } .prerendered .h3-inline { FONT-STYLE: italic; COLOR: #336699; FONT-SIZE: 1em; FONT-WEIGHT: bold } .prerendered H4 { FONT-STYLE: italic; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; COLOR: = #336699; FONT-SIZE: 1em } .prerendered .h4-inline { FONT-STYLE: italic; COLOR: #336699; FONT-SIZE: 1em } .prerendered H5 { MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0.4em; FONT-SIZE: 1em } .prerendered .h5-inline { FONT-STYLE: normal; DISPLAY: inline; FONT-SIZE: 1em; FONT-WEIGHT: bold } .prerendered .heading5-inline { DISPLAY: block; COLOR: #666666; FONT-SIZE: 100%; FONT-WEIGHT: bold } .prerendered .correspondence-address { MARGIN-TOP: 8pt; DISPLAY: block } .prerendered .bpg40copyright { MARGIN-TOP: 16pt; DISPLAY: none } .prerendered .doi-block { MARGIN-TOP: 16pt; DISPLAY: block; MARGIN-BOTTOM: 8pt } .prerendered .doi-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .keywords-block { MARGIN-TOP: 16pt; DISPLAY: block } .prerendered .keyword-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .abstract-content { DISPLAY: block; CLEAR: left; PADDING-TOP: 1pt } .prerendered .b { FONT-WEIGHT: bold } .prerendered .highlight { FONT-WEIGHT: bold } .prerendered .i { FONT-STYLE: italic } .prerendered .overline { TEXT-DECORATION: overline } .prerendered .slanted { FONT-STYLE: oblique } .prerendered .smallcapitals { FONT-VARIANT: small-caps } .prerendered .strike { TEXT-DECORATION: line-through } .prerendered .tt { FONT-FAMILY: "Courier","Lucida Sans Typewriter","Courier = New","LucidaTypewriter", fixed } .prerendered .u { TEXT-DECORATION: underline } .prerendered .uu { TEXT-DECORATION: underline } .prerendered .openface { =09 } .prerendered .roman { FONT-STYLE: normal } .prerendered .sansserif { FONT-FAMILY: sans-serif } .prerendered .scriptface { =09 } .prerendered .questiongroup { =09 } .prerendered .question { =09 } .prerendered .answer { =09 } .prerendered .hint { =09 } .prerendered .feedback { =09 } .prerendered .toc-content { =09 } .prerendered .toc-journal-title { FONT-WEIGHT: bold } .prerendered .toc-issn { =09 } .prerendered .toc-vol-issue { MARGIN-TOP: 12pt } .prerendered .toc-pages { =09 } .prerendered .toc-sections { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt } .prerendered .toc-tables { =09 } .prerendered .toc-figures { =09 } .prerendered .toc-abstract-only { =09 } .prerendered .block_formula { POSITION: relative; MARGIN: 1em 0pt; WIDTH: 98%; DISPLAY: block; = WHITE-SPACE: nowrap } .prerendered .block_formula .formula_caption { POSITION: absolute; TOP: 33%; RIGHT: 0px } .prerendered .block_formula .formula_display { =09 } .prerendered .inline_formula IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .reference-document-title { =09 } .prerendered .reference-subtitle-title { =09 } .prerendered .reference-journal-title { FONT-STYLE: italic } .prerendered .reference-book-title { FONT-STYLE: italic } .prerendered .reference-conference-title { =09 } .prerendered .reference-other-title { =09 } .prerendered .reference-date { =09 } .prerendered .reference-volume { FONT-WEIGHT: bold } .prerendered .reference-page { =09 } .prerendered .reference-publisher { =09 } .prerendered .reference-edition { =09 } .prerendered .reference-issue { =09 } .prerendered .reference-thesis { =09 } .prerendered .reference-inpress { =09 } .prerendered .reference-supplement { =09 } .prerendered .reference-miscellaneoustext { =09 } .prerendered .figure-legend { FONT-SIZE: 0.8em; FONT-WEIGHT: bold } .prerendered P.legend-para { MARGIN-TOP: 0em; MARGIN-BOTTOM: 0em; MARGIN-LEFT: 1.6em } .prerendered .figure { MARGIN-BOTTOM: 6pt } .prerendered .image-links { MARGIN-LEFT: 2em; FONT-SIZE: 0.8em } .prerendered .table-legend { =09 } .prerendered .toc-content { =09 } .prerendered TABLE.data-table TH { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } .prerendered TABLE.data-table TD { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 10px; = PADDING-TOP: 0px } .prerendered .bp_abstractinfo { DISPLAY: none } .prerendered .header-footnotes { MARGIN-TOP: 6pt } .prerendered .inline_image IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .fixed-image { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered .fixed-legend { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered A.externallink { COLOR: #336699 } .prerendered .subsection-box { BACKGROUND-COLOR: #f9e3df } .prerendered .tbltl { MARGIN-TOP: 0.5em } .prerendered .bookdetails { MARGIN-TOP: 8pt; MARGIN-BOTTOM: 8pt } .prerendered .references .reference-content { DISPLAY: inline } .prerendered .para .reference-content { DISPLAY: inline } .prerendered .reference-content { DISPLAY: block } ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/js/links.js // These are the JavaScript functions required for outbound linking from =0A= // Wiley InterScience. (AID April 2000)=0A= // Approach copied from Andy's SFX js.=0A= // ChrisNS 20020320 - added setEarlyView()=0A= =0A= //version check=0A= var version =3D 1;=0A= var appname =3D "";=0A= var artDOI =3D "";=0A= var artEarlyView =3D "EVIEW=3DY"; // EarlyView defaults to Y=0A= var artEnableISI =3D "ENABLEISI=3DN"; //Enable ISI linking from journal = articles=0A= var artTurnOnCas =3D "ENABLECAS=3DY"; // Turn on CAS linking=0A= var artEnablePubMed =3D "ENABLEPM=3DY"; // Turn on PubMed linking=0A= =0A= if (navigator.appName.indexOf("Netscape") >=3D 0) { appname =3D "ns"; }=0A= else if (navigator.appName.indexOf("Explorer") >=3D 0) { appname =3D = "ie"; }=0A= if (navigator.userAgent.indexOf("Mozilla/2") >=3D 0) {=0A= version =3D 2;=0A= } else if (navigator.userAgent.indexOf("Mozilla/3") >=3D 0) {=0A= version =3D 3;=0A= } else if (navigator.userAgent.indexOf("Mozilla/4") >=3D 0) {=0A= version =3D 4;=0A= } else if (navigator.userAgent.indexOf("Mozilla/5") >=3D 0) {=0A= version =3D 5;=0A= }=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Get the cookies named "REF_LNX and SRC_LNX"... deprecated for now. = Always set.=0A= // Instead set the hypertext for linking.=0A= //var anchorString =3D '3D"extended';=0A= var anchorString =3D 'Links';=0A= var targString =3D ' target=3D_top';=0A= var anchor2 =3D 'links';=0A= =0A= //NEW for special content linking. Anchor string must be taken from SGML.=0A= var contAnchor =3D '';=0A= =0A= // Linking functions=0A= =0A= =0A= //Get the EarlyView flag of the citing article which is needed to ensure = that the link is suitable for ISI WoS.=0A= // The CONTROL details are passed in, in the form -----. only grab the = 2nd of 5 characters which is the EarlyView flag=0A= function setEarlyView(object)=0A= {=0A= if ((version >=3D 3) && (object.substring(1,2) !=3D "Y"))=0A= {=0A= artEarlyView =3D "EVIEW=3DN"; =0A= }=0A= }=0A= =0A= //Get the DOI of the citing article which is needed for the ISI links.=0A= function setDOI(object){=0A= if (version >=3D 3)=0A= {=0A= artDOI =3D object;=0A= }=0A= }=0A= =0A= function setISSN(object)=0A= {=0A= }=0A= =0A= // Print out the reference link. =0A= function print_link(object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= // remove over-escaped ampersands (ref bugzilla 5515)=0A= var overEscapedAmpersandsRemoved =3D object.replace(new = RegExp('&','g'), '&');=0A= =0A= // remove "BIB" prefix from the value of BIBID (for ISI linking)=0A= // note, this could be performed in LNX. Need to reassess where this = should be done.=0A= var re =3D new RegExp ('BIBID=3DBIB', 'i') ;=0A= var paramstring =3D new String();=0A= paramstring =3D overEscapedAmpersandsRemoved.replace(re, 'BIBID=3D');=0A= =0A= var unpCookie =3D '/cgi-bin/reflink?object=3D' + escape(paramstring = + "&" + artDOI + "&" + artEarlyView + "&" + artEnableISI + "&" + = artTurnOnCas + "&" + artEnablePubMed);=0A= if (netscape4 =3D=3D false)=0A= {=0A= document.write ('' + anchorString + '  ');=0A= }=0A= else // protect against inline style application hanging NN4=0A= {=0A= document.write ('' + = anchorString + '  '); =0A= }=0A= }=0A= else=0A= {=0A= document.writeln();=0A= } =0A= }=0A= =0A= //Print out source links (in the citing article)=0A= function print_SRClink(object){=0A= if (version >=3D 3)=0A= {=0A= var unpCookie =3D '/cgi-bin/srclink?object=3D' + escape(object);=0A= var url =3D unpCookie;=0A= document.write ('
  • Find = other ');=0A= document.write (anchor2.link(url));=0A= document.write (' for this article.
    • ');=0A= }=0A= else=0A= {=0A= document.writeln();=0A= } =0A= }=0A= =0A= // Links for journal citations=0A= function print_JCIT(object)=0A= {=0A= if (object.match(/JTL/) !=3Dnull)=0A= {=0A= print_link(object); =0A= } =0A= }=0A= =0A= // Links for book citations=0A= function print_BKCIT(object){=0A= }=0A= =0A= // Links for electronic path citations=0A= function print_EPATHCIT(object){=0A= }=0A= =0A= // Links for patent citations=0A= function print_PATENTCIT(object){=0A= }=0A= =0A= // Links for standard citations=0A= function print_STANDARDCIT(object){=0A= }=0A= =0A= // Links for other citations, e.g., theses, proceedings, personal = communications=0A= function print_OTHERCIT(object){=0A= }=0A= =0A= //NEW functions for special content linking. (AID Sept 5 2000)=0A= =0A= // print an anchor with the specified text and calling linking program.=0A= =0A= function print_contentlink_start(conttext, object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= if (object.match(/URL/) !=3D null || object.match(/ACC/) !=3D null)=0A= {=0A= object =3D object + "&TEXT=3D" + conttext;=0A= var unpCookie =3D '/cgi-bin/contlink?object=3D' + escape(object);=0A= document.write ('');=0A= }=0A= }=0A= document.writeln();=0A= =0A= }=0A= =0A= function print_contentlink_end(object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= if (object.match(/URL/) !=3D null || object.match(/ACC/) !=3D null)=0A= {=0A= document.write('');=0A= }=0A= } =0A= document.writeln();=0A= =0A= }=0A= =0A= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/FIGJS =0A= =0A= function newfigwin() {var hwnd =3D window.open('', 'Figures', = 'dependent=3D0,toolbar=3D1,location=3D0,status=3D0,menubar=3D0,scrollbars= =3D1,resizable=3D1,width=3D600,height=3D400'); return hwnd; } =0A= function pagetitle() {return 'Int. J. Cancer Vol.9999, 9999 Pages: NA'; = } =0A= function dochead(hwnd, spec) {var title =3D pagetitle(); = hwnd.document.open(); = hwnd.document.write(''+spec+title+''); } =0A= function doctail(hwnd) {hwnd.document.write(''); } =0A= function pagehead(hwnd) {hwnd.document.write('
    3D"About

    Online ISSN: 1097-0215    Print ISSN: = 0020-7136
    International Journal of Cancer
    Volume 9999, Issue 9999, 2009. = Pages: NA

    Copyright = © 2008 Wiley-Liss, Inc.

    '); } =0A= function copyright(hwnd) {var title =3D pagetitle(); = hwnd.document.write(title.bold() + '
    Copyright © 2009 = Wiley-Liss, Inc., A Wiley Company
    '); } =0A= function imagelink(hwnd, iname) {hwnd.document.write('
    '); } =0A= function otherlinks(hwnd, iname, size) {hwnd.document.write('View Normal Image '); else = hwnd.document.write('(1) target=3Dmain >View Magnified Image '); = hwnd.document.write('View List of Images '); hwnd.document.write('

    '); } =0A= function caption_fig001(hwnd) { hwnd.document.write('Figure 1. Effects of NK012 and CPT-11 on U87MG/Luc tumor xenograft. (a) = Tumor volume in mice treated with CPT-11 or NK012. U87MG/Luc tumor was = subcutaneously inoculated into the flank of mice, as described in the Materials and = methods section. NaCl (0.9%) solution (), CPT-11 at 66.7 mg/kg = () and NK012 at 30 = mg/kg () were = intravenously administered on days 0, 4 and 8 (arrows). Points, mean; = bars, SD. *p < 0.05. (b) Treatment-related body = weight loss occurred in mice treated with CPT-11 and NK012. Points, = mean; bars, SD.
    '); } =0A= function gcaption_fig001(hwnd) { hwnd.document.write('Wiley-Liss, Inc.

    '); } =0A= function display_fig001(size) { var i =3D new Array(); i[0] =3D = 'nfig001'; i[1] =3D 'mfig001'; var hwnd =3D newfigwin(); dochead(hwnd, = ''); copyright(hwnd); otherlinks(hwnd, 'fig001', size); imagelink(hwnd, = i[size]); gcaption_fig001(hwnd); caption_fig001(hwnd); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= function caption_fig002(hwnd) { hwnd.document.write('Figure 2. Distribution of NK012 or CPT-11 in U87MG/Luc glioma xenografts. Mice = bearing U87MG/Luc tumor were injected with NK012 (30 mg/kg/day) or = CPT-11 (66.7 mg/kg/day). Tumor tissues were excised 2, 12 and 24 hr = after the intravenous injection of NK012 or CPT-11. Each mouse was = administered fluorescein-labeled Lycopersicon esculentum lectin = 5 min before sacrifice to detect tumor blood vessels. Frozen sections = were examined under a fluorescence microscope at an excitation = wavelength of 377 nm and an emission wavelength of 477 nm. The same = fluorescence conditions can be applied for visualizing NK012 and CPT-11 = fluorescence. Free SN-38 could not be detected under these fluorescence = conditions. The white lines indicate the border between the tumor and = the brain tissue. T, U87MG/Luc tumor; B, normal brain tissue. (Scale = bars: 20 m).
    '); } =0A= function gcaption_fig002(hwnd) { hwnd.document.write('Wiley-Liss, Inc.

    '); } =0A= function display_fig002(size) { var i =3D new Array(); i[0] =3D = 'nfig002'; i[1] =3D 'mfig002'; var hwnd =3D newfigwin(); dochead(hwnd, = ''); copyright(hwnd); otherlinks(hwnd, 'fig002', size); imagelink(hwnd, = i[size]); gcaption_fig002(hwnd); caption_fig002(hwnd); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= function caption_fig003(hwnd) { hwnd.document.write('Figure 3. Plasma, brain tissue and orthotopic tumor concentrations of respective = analytes after intravenous administration of NK012 (30 mg/kg/day) and = CPT-11 (66.7 mg/kg/day) to U87MG/Luc-bearing nude mice. (a) = plasma; (b) tumor. , polymer-bound SN-38; , free SN-38 (polymer-unbound SN-38); , CPT-11; , free SN-38 converted = from CPT-11.
    '); } =0A= function gcaption_fig003(hwnd) { hwnd.document.write('Wiley-Liss, Inc.

    '); } =0A= function display_fig003(size) { var i =3D new Array(); i[0] =3D = 'nfig003'; i[1] =3D 'mfig003'; var hwnd =3D newfigwin(); dochead(hwnd, = ''); copyright(hwnd); otherlinks(hwnd, 'fig003', size); imagelink(hwnd, = i[size]); gcaption_fig003(hwnd); caption_fig003(hwnd); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= function caption_fig004(hwnd) { hwnd.document.write('Figure 4. Antitumor effect of NK012 or CPT-11 on orthotopic xenograft and = survival. Mice receiving intracranial injections of U87MG/Luc were = assigned into groups 20 days after tumor inoculation. Mice were = intravenously administered with 0.9% NaCl solution (), NK012 (30 mg/kg/day, = ) or CPT-11 (66.7 = mg/kg/day, ) on days 0 = (20 days after tumor inoculation), 4 and 8 (arrows). (a) = Representative luminescence intensity images obtained in individual = control and treatment-group mice on the days indicated. (b) = Antitumor effect of NK012 or CPT-11 on days 14, 21 and 28. Each group = consisted of 4 mice. Points, mean; bars, SD. *p < 0.05. (c) Treatment effects of NK012 on survival. Survival was assessed = by Kaplan-Meier analysis. Each group consisted of 6 mice. Experiments = were repeated twice with similar results.
    '); } =0A= function gcaption_fig004(hwnd) { hwnd.document.write('Wiley-Liss, Inc.

    '); } =0A= function display_fig004(size) { var i =3D new Array(); i[0] =3D = 'nfig004'; i[1] =3D 'mfig004'; var hwnd =3D newfigwin(); dochead(hwnd, = ''); copyright(hwnd); otherlinks(hwnd, 'fig004', size); imagelink(hwnd, = i[size]); gcaption_fig004(hwnd); caption_fig004(hwnd); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= function imagelist() {var hwnd =3D newfigwin(); dochead(hwnd, 'List of = Images - '); copyright(hwnd); hwnd.document.write(''); hwnd.document.write(''); hwnd.document.write(''); hwnd.document.write(''); hwnd.document.write(''); hwnd.document.write('
    '); caption_fig001(hwnd); = hwnd.document.write('
    [Normal View 22K | Magnified View = 59K]
    '); caption_fig002(hwnd); = hwnd.document.write('
    [Normal View 52K | Magnified View = 283K]
    '); caption_fig003(hwnd); = hwnd.document.write('
    [Normal View 22K | Magnified View = 59K]
    '); caption_fig004(hwnd); = hwnd.document.write('
    [Normal View 39K | Magnified View = 114K]
    '); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } =0A= ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/121534411/main.html,ftx_abs Wiley InterScience = :: Article Full Text HTML = = =
    3D""=20

    International Journal of Cancer

    =20 What=20 is RSS?

    Early View =   (Articles=20 online in advance of print)

    Published Online: 24 Nov 2008

    Copyright =A9 2009 Wiley-Liss, Inc., A Wiley Company

    3D"Journal
    3D"E-Mail3DE-Mail3DPrint
    =20
    =20

    3DSearch
    Publication = Titles
    =20
    =20
    3D""=20

    < Previous Article  |  Next Article=20 >

    3D""=20 Save Article to My Profile=20      3D""=20 Download Citation=20

    Abstract  |  References  |  Full Text: = HTML=20

    View Full Width
    3D""=20
    3D""=20
     Fast Track
    =
    Potent antitumor effect of=20 SN-38-incorporating polymeric micelle, NK012, against = malignant=20 glioma
    Jun-ichiro Kuroda 1 2, = Jun-ichi=20 Kuratsu 2, Masahiro=20 Yasunaga 1, Yoshikatsu=20 Koga 1, Yohei = Saito 1, Yasuhiro Matsumura=20 1 *
    1Investigative Treatment = Division, Research Center for Innovative Oncology, National = Cancer=20 Center Hospital East, Kashiwa, Japan
    2Department of Neurosurgery, Faculty = of Medical=20 and Pharmaceutical Sciences, Kumamoto University, Kumamoto,=20 Japan
    email: Yasuhiro Matsumura (yhmatsum@east.ncc.go.jp)

    *Correspondence to Yasuhiro = Matsumura,=20 Investigative Treatment Division, Research Center for Innovative = Oncology,=20 National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa = 277-8577,=20 Japan

    Fax:=20 +81-4-7134-6857

    Funded by:
     M= inistry=20 of Health
     L= abour=20 and Welfare of Japan (Third Term Comprehensive Contorol Research = for=20 Cancer)
     C= ore=20 Research for Evolutional Science and Technology
     M= inistry=20 of Education, Culture, Sports, Science and Technology

    Keywords
    glioma =95 drug delivery system =95 blood brain barrier = (BBB) =95=20 SN-38 =95 micelles

    Abstract
    3DAbstract=20 = = = = =
    Recent published reports on clinical trials of CPT-11 = indicate=20 the effectiveness of this compound, a prodrug of SN-38, = against=20 malignant glioma in combination with anti-vascular = endothelial=20 growth factor antibody. Here, we determined if NK012, and = SN-38=20 incorporating micelle, can be an appropriate formulation for = glioblastoma treatment compared with CPT-11. In vitro = cytotoxicity was evaluated against several glioma lines with = NK012,=20 CPT-11, SN-38, ACNU, CDDP and etoposide. For the in = vivo=20 test, a human glioma line (U87MG) transfected with the=20 luciferase gene was inoculated into nude mice brain = for=20 pharmacokinetic analysis by fluorescence microscopy and=20 high-performance liquid chromatography after intravenous = injection=20 of NK012 and CPT-11. In vivo antitumor activity of = NK012 and=20 CPT-11 was evaluated by bioluminescence image and = Kaplan-Meier=20 analyses. The growth-inhibitory effects of NK012 were 34- to = 444-fold more potent than those of CPT-11. Markedly enhanced = and=20 prolonged distribution of free SN-38 in the xenografts was = observed=20 after NK012 injection compared with CPT-11. NK012 showed=20 significantly potent antitumor activity against an = orthotopic=20 glioblastoma multiforme xenograft and significantly longer = survival=20 rate than CPT-11 (p =3D 0.0014). This implies that = NK012 can=20 pass through the blood brain tumor barrier effectively. = NK012, which=20 combines enhanced distribution with prolonged sustained = release, may=20 be ideal for glioma treatment. Currently, a phase I study of = NK012=20 is almost complete in Japan and the US. The present = translational=20 study warrants the clinical phase II study of NK012 in = patients with=20 malignant glioma. =A9 2008 Wiley-Liss, = Inc.

    Received: 10 September 2008; Accepted: 28 October 2008

    Digital Object = Identifier=20 = (DOI)

    10.1002/ijc.24171  About=20 DOI

    Article=20 Text

    Malignant astrocytomas, such as anaplastic astrocytoma and = glioblastoma=20 multiforme (GBM), are the most common and highly vascularized = glial tumors=20 of the brain. At least 80 percent of malignant gliomas are = categorized as=20 GBM.[1]=20 Currently, GBM patients have a mean survival of only 50 weeks = following=20 the standard treatment consisting of surgical and adjuvant = therapies.[2]=20 A recent phase III randomized trial for newly diagnosed GBM = demonstrated=20 that radiation therapy with concurrent temozolomide treatment, = followed by=20 6 months of temozolomide treatment was superior to radiation = therapy alone=20 in terms of overall survival.[3]=20 In addition, several clinical trials have demonstrated that the = median=20 survival times of patients with recurrence were only 3-6 = months.[4]

    The anticancer plant alkaloid 7-ethyl-10-hydroxy-camptothecine = (SN-38)=20 is a broad spectrum anticancer agent targeting DNA topoisomerase I = with a=20 different mechanism of action compared with alkylating agents such = as=20 temozolomide. Although SN-38 has shown promising anticancer = activity in=20 vitro and in vivo, its clinical application has = remained=20 dormant because of its low therapeutic efficacy and severe toxic=20 effects.[5][6]=20 Irinotecan hydrochloride (CPT-11), a prodrug of SN-38, shows some=20 antitumor activities in patient with recurrent GBM, with response = rates of=20 0 to 17% in several trials.[7-10]=20 CPT-11 activity is thus similar to that of other agents used for = recurrent=20 GBM.[9]=20 A recent phase II trial for recurrent GBM demonstrated that the=20 combination of CPT-11 and bevacizumab, an antivascular endothelial = growth=20 factor (VEGF) monoclonal antibody, is an effective treatment = against the=20 neoplasia with a 6-month progression-free survival rate of 46% and = a=20 6-month overall survival rate of 77%.[11][12]=20 However, there is an increased risk of developing venous = thromboembolic=20 disease and intracranial hemorrhage with this combination therapy. = Therefore, there is an urgent need to develop treatment modalities = by=20 which cytotoxic drugs can exert more potent antitumor activity to = their=20 full potential with modest adverse effects and thereby reasonably = prolong=20 the overall survival in GBM patients.

    The purpose of the drug delivery system (DDS) is to achieve = selective=20 delivery of antitumor agents to tumor tissue at an effective = concentration=20 for the appropriate duration of time in order to reduce the = adverse=20 effects of the administered drug and simultaneously enhance its = antitumor=20 effect. There are 2 main concepts in DDS, active targeting and = passive=20 targeting. Active targeting involves a monoclonal antibody and a = ligand to=20 a tumor-related receptor. Doxil, a doxorubicine incorporated = polyethylene=20 glycol conjugated liposome, is categorized under passive targeting = agents=20 and are already in clinical use.[13][14]=20 NK012, a novel SN-38-incorporating polymeric micelle, is a prodrug = of=20 SN-38 similar to CPT-11 and categorized under passive targeting = agent as=20 well. Although CPT-11 is converted to SN-38 in tumors by = carboxylesterase=20 (CE), the metabolic conversion rate is within 2-8% of the original = volume=20 of CPT-11.[15][16]=20 In contrast, the release rate of SN-38 from NK012 is 74% under = physiologic=20 pH condition even without CEs.[17]=20 Recently, we have demonstrated that NK012 exerted significantly = more=20 potent antitumor activity against various human tumor xenografts = than=20 CPT-11.[17-20]=20 However, there is a fundamental question whether such = nanoparticles can=20 reach brain tumors across the tumor microvessels. In the present = study,=20 therefore, we established an orthotopic glioma model in this = experiment=20 and then evaluated whether NK012 can pass through the BTB and = exert its=20 antitumor effect on orthotopic human glioma xenografts in = comparison with=20 CPT-11.

    Material and = methods
    3D"Material = = = =

    Drugs

    NK012 and SN-38 were donated by Nippon Kayaku Co., Ltd. (Tokyo, = Japan).=20 The size of NK012 was 20 nm = in=20 diameter with a narrow size distribution.[17]=20 ACNU [1-(4-amino-2-methyl-5- pyrimidinyl)=20 methyl-3-(2-chloroethyl)-3-nitrosourea, nimstine] was purchased = from=20 DAIICHI SANKYO Co., Ltd. (Tokyo, Japan). CDDP=20 (cis-diamminedichloroplatinum) and CPT-11 were purchased from = Yakult Co.,=20 Ltd. (Tokyo, Japan). Etoposide [4demeth= lepipodophyllotoxin-9-(4,=20 6-O-ethylidene--D-gluc= opyranoside)]=20 was purchased from BIOMOL (Plymouth Meeting, PA).

    Cells and = animals

    Five human glioma cell lines, namely U87MG, U251MG, U118MG, = LN18 and=20 LN229, were obtained from the American Type Culture Collection = (Rockville,=20 MD). Cells were maintained in Dulbecco's modified Eagle's minimum=20 essential medium supplemented with 10% fetal bovine serum (Cell = Culture=20 Technologies, Gaggenau-Hoerden, Germany), penicillin, streptomycin = and=20 amphotericin B (100 units/ml, 100 g/ml and = 25=20 g/ml,=20 respectively; Sigma, St. Louis, MO) in a humidified atmosphere = containing=20 5% CO2 at 37=B0C. Six- to eight-week-old athymic nude = mice=20 (nu/nu; Charles River Japan, Kanagawa, Japan) were used for this = study.=20 U87MG cells (1 =D7 105) were injected into the cerebral = hemisphere using a Hamilton syringe through an entry point 1 mm = anterior=20 and 1.8 mm lateral to the bregma to an intraparenchymal depth of = 2.5 mm.=20 The rate of injection was 0.5 l/min, = and=20 the needle was left in place for 5 min after completion of the = injection.=20 All animal procedures were performed in compliance with the = Guidelines for=20 the Care and Use of Experimental Animals established by the = Committee for=20 Animal Experimentation of the National Cancer Center, Japan; these = guidelines meet the ethical standards required by law and also = comply with=20 the guidelines for the use of experimental animals in Japan.

    Establishment of = U87MG cell=20 line stably expressing firefly luciferase and YFP mutant = Venus

    For the in vivo bioluminescence imaging of orthotopic = brain=20 tumors, the U87MG cell line stably expressing firefly luciferase = and the=20 YFP mutant Venus was established. Briefly, the coding sequence for = firefly=20 luciferase and Venus was subcloned into the the pIRES Vector = (Clontech=20 Laboratories, Mountain View, CA). The fragment consists of=20 Luciferase-IRES-Venus generated from the plasmid with the = restriction=20 enzymes Nhe I and Not I. This fragment was subcloned into the = pEF6/V5-His=20 Vector (Invitrogen, Carlsbad, CA) to generate plasmids of = pEF6-Lucifease=20 IRES Venus. U87MG cells (2 =D7 106) were seeded onto = 10-cm dishes=20 24 hr before transfection. The cells were transfected with 10 g = of=20 pEF6-Lucifease IRES Venus using FuGENE HD Transfection Reagent = (Roche=20 Diagnostics, Mannheim, Germany) according to manufacturer's = instructions,=20 and then incubated for 48 hr at 37=B0C. The cells were then = passaged in=20 medium containing Blasticidin (10 g/ml;=20 InvivoGen, San Diego, CA) to select for the Blasticidin resistance = gene=20 integrated in the pEF6/V5-His plasmids. Venus expression was used = as a=20 surrogate marker of luciferase-positive cells. Venus-expressing = U87MG=20 cells (U87MG/Luc) were sorted using the BD FACS Aria cell sorter = (BD=20 Biosciences, San Jose, CA), and expanded in selection medium. The = accuracy=20 of a quantitive bioluminescence image as an indicator of U87MG/Luc = cell=20 number was analyzed using the Photon Imager animal imaging system = in=20 vitro, as described under in vivo growth inhibition = assay. This=20 analysis demonstrated clear correlation between a quantitive=20 bioluminescence image and cell number (R2 =3D = 0.99). The=20 sensitivity of U87MG/Luc cells to each drug (NK012, CPT-11, SN-38, = ACNU,=20 CDDP and etoposide) was almost similar to that of parental U87MG = cells=20 (data not shown).

    In vitro growth = inhibition=20 assay

    Cell growth inhibition was measured by the tetrazolium = salt-based=20 proliferation assay (WST assay; Wako Chemicals, Osaka, Japan). = Briefly,=20 cells (5 =D7 103 cells/well) in 96-well plates were = incubated=20 overnight. Then, growth medium was changed to new medium with = various=20 concentrations of SN-38, NK012, CPT-11, ACNU, etoposide and CDDP. = After 72=20 hr of incubation, medium was changed to new medium containing 10% = WST-8=20 reagents. After 1 hr of incubation, the absorbance of the formazan = product=20 formed was detected at 450 nm in a 96-well spectrophotometric = plate reader=20 (SpectraMax 190; Molecular Devices, Sunnyvale, CA). Cell viability = was=20 measured and compared with that of the control cells. Each = experiment was=20 carried out in triplicates and was repeated at least 3 times. Data = were=20 averaged and normalized against the nontreated controls to = generate=20 dose-response curves. The number of living cells (% Control) was=20 calculated using the following formula: % Control =3D (each=20 absorbance - absorbance of blank well)/absorbance of = control=20 well =D7 100.

    Evaluation of = NK012 and CPT-11=20 distribution in tumor tissue by fluorescence microscopy

    The U87MG orthotopic xenograft model described earlier was used = for the=20 analysis of the biodistribution of NK012 and CPT-11. Twenty days = after=20 U87MG/Luc inoculation, the maximum tolerated dose (MTD) of NK012 = (30=20 mg/kg) or CPT-11 (66.7 mg/kg) was injected intravenously into the = tail=20 vein of mice. At this point, tumor size reached to about 3 mm in = diameter=20 according to the preliminary experiment (data not shown). Two, 12 = or 24 hr=20 after NK012 or CPT-11 injection, mice were also administered with=20 fluorescein Lycopersicon esculentum lectin (100 l/mouse) = (Vector Laboratories, Burlingame, CA) to visualize tumor blood = vessels.=20 Tumors were then excised and embedded in optimal cutting = temperature=20 compound and frozen at -80=B0C until use. Tissue sections (6 m = thick)=20 were prepared using Tissue-Tek Cryo3 (Sakura Finetek USA, Inc., = Torrance,=20 CA), and frozen sections were examined under a fluorescence = microscope,=20 BIOREVO BZ9000 (Keyence, Osaka, Japan), at an excitation = wavelength of 377=20 nm and an emission wavelength 447 nm to evaluate the distribution = of=20 CPT-11 and NK012 within the tumor tissues. Because formulations = containing=20 SN-38 bound via ester bonds possess a particular = fluorescence, both=20 CPT-11 and NK012 were detected under the same fluorescence = conditions.=20 Image data were recorded using BZ-II Analyzer 1.10 software = (Keyence,=20 Osaka, Japan).

    Pharmacokinetics = study of=20 NK012 and CPT-11

    Female BALB/c nude mice bearing U87MG/Luc tumor (n =3D = 3) were=20 used for the analysis of the biodistribution of NK012 and CPT-11. = Twenty=20 days after the intracranial injection of U87MG/Luc cells, NK012 = (30 mg/kg)=20 or CPT-11 (66.7 mg/kg) was intravenously administered to the mice. = Under=20 anesthesia, blood, normal brain tissues and tumor tissues were = obtained 2,=20 12, 24 and 72 hr after NK012 or CPT-11 administration. Blood = samples were=20 collected in microtubes and immediately centrifuged at = 1,600g for=20 15 min at 4=B0C. All samples were stored at -80=B0C until use.

    The normal brain and tumor samples were rinsed with physiologic = 0.9%=20 NaCl solution, mixed with 0.1 M glycine-HCl buffer (pH = 3.0)/methanol at 5=20 w/w%, and then homogenized. To analyze the concentration of free = SN-38 and=20 CPT-11, 100 l = of the=20 tumor homogenates was mixed with 20 l = of 1 mM=20 phosphoric acid/methanol (1:1), 40 l = of=20 ultrapure water and 60 l = of=20 camptothecin solution (10 ng/ml for SN-38 and 15 ng/ml for CPT-11) = as an=20 internal standard. To quantify free SN-38 and CPT-11 in plasma, 25 = l = of plasma=20 was mixed with 25 l = of 0.1 M=20 HCl, and then added with 20 l = of 1 mM=20 phosphoric acid/methanol (1:1) and 100 l = of CPT=20 solution (10 ng/ml both for SN-38 and CPT-11). The samples were = vortexed=20 vigorously for 10 sec, and then filtered through Ultrafree-MC = centrifugal=20 filter devices with a cut-off molecular diameter of 0.45 m = (Millipore=20 Co., Bedford, MA). Reversed-phase HPLC was performed at 35=B0C on = a=20 Mightysil RP-18 GP column 150 =D7 4.6 mm2 (Kanto = Chemical Co.,=20 Inc., Tokyo, Japan). Fifty microliters of a sample was injected = into an=20 Alliance Waters 2795 HPLC system (Waters, Milford, MA) equipped = with a=20 Waters 2475 multi =20 fluorescence detector. Fluorescence originating from SN-38 was = detected at=20 540 nm with an excitation wavelength of 365 nm and that = originating from=20 CPT-11 was detected at 430 nm with an excitation wavelength of 365 = nm. The=20 mobile phase was a mixture of 100 nmol/l ammonium acetate (pH 4.2) = and=20 methanol (11:9 (v/v)). The flow rate was 1.0 ml/min. The content = of SN-38=20 was calculated by measuring the relevant peak area and calibrating = against=20 the corresponding peak area derived from the CPT internal = standard. Peak=20 data were recorded using a chromatography management system = (MassLynx=20 v4.0, Waters).

    For polymer-bound SN-38 detection, SN-38 was released from the=20 conjugate. Briefly, 20 l = of plasma=20 and 100 l = of tissue=20 samples were diluted with 20 l = of=20 methanol (50%, v/v) and 20 l = of NaOH=20 (0.3 mol/l for plasma and 0.7 mol/l for tissue). The samples were=20 incubated for 15 min at 25=B0C. After incubation, 20 l = of HCl=20 (0.3 mol/l for plasma and 0.7 mol/l for tissue) and 60 l = of CPT=20 solution (10 ng/ml for SN-38 and 15 ng/ml for CPT-11) were added = to the=20 samples, and then the hydrolysate was filtered through a = MultiScreen=20 Solvinert. Fifty microliters of the filtrate was applied to the = same HPLC=20 system as described earlier.

    In vivo growth = inhibition=20 assay

    Experiment = 1

    Six-week-old mice were subcutaneously inoculated with 1 =D7=20 107 U87MG/Luc cells in the flank region. When tumor = volume=20 reached 605=20 mm3, mice were randomly divided into test groups = consisting of=20 3 mice per group (day 0). Drug was intravenously administered on = days 0, 4=20 and 8 into the tail vein. NK012 was administered at its MTD of 30=20 mg/kg/day. The reference drug CPT-11 was given at its MTD of 66.7=20 mg/kg/day in the optimal schedule reported.[17][21]=20 The length (i) and width (ii) of tumor masses were = measured=20 twice a week, and tumor volume (TV) was calculated as follows: TV = =3D (a =D7=20 b2)/2. Relative tumor volumes (RTVs) at day n = were=20 calculated according to the following formula: RTV =3D = TVn=20 / TV0, where TVn is the tumor volume = at day=20 n, and TV0 is the tumor volume at day 0.

    Experiment = 2

    To assess the antitumor effect of NK012 and CPT-11, in = vivo=20 bioluminescence imaging studies were performed using the Photon = Imager=20 animal imaging system (Biospace, Paris, France). For imaging, mice = with=20 intracranial U87MG/Luc tumor were simultaneously anesthetized with = isoflurane and D-luciferine potassium salt = (Synchem,=20 Germany), and normal 0.9% NaCl solution was intraperitoneally=20 administrated at a dose of 125 mg/kg body weight, and images were = obtained=20 5 min after the injection. For bioluminescence image analysis, = regions of=20 interest encompassing the intracranial area of a signal were = defined using=20 Photo Vision software (Biospace, Paris, France), and total numbers = of=20 photons per minute (cpm) were recorded. The pseudo-color = luminescent image=20 from violet (least intense) to red (most intense) represented the = spatial=20 distribution of detected photon counts emerging from active = luciferase=20 within the animal. Twenty days after U87MG inoculation, treatment = was=20 started (day 0). Normal 0.9% NaCl solution (n =3D 4), NK012 = (30=20 mg/kg, n =3D 4), or CPT-11 (66.7 mg/kg, n =3D 4) was = intravenously administered to mice on days 0, 4 and 8. In = vivo=20 bioluminescence imaging studies were performed on days 0, 14, 21 = and 28=20 from the day of treatment initiation. To determine the effect of = treatment=20 on the time to change of intensity, Student's t test was = carried=20 out using the StatView 5.0 software package. p < 0.05 = was=20 regarded as significant.

    Experiment = 3

    Mice with intracranial U87MG/Luc tumor was randomly divided = into 3=20 groups consisting of 6 mice per group. NK012 (30 mg/kg/day) and = CPT-11=20 (66.7 mg/kg/day) were intravenously given on days 0 (20 days after = tumor=20 inoculation), 4 and 8. After treatment, mice were maintained until = each=20 animal showed signs of morbidity (i.e., 10% weight loss and = neurological deficit), at which point they were sacrificed. = Kaplan-Meier=20 analysis was performed to determine the effect of drugs on time to = morbidity, and statistical differences were ranked according to = the=20 Mantel-Cox log-rank test using StatView 5.0.

    Statistical = analysis

    Data were expressed as mean =B1 SD. Significance of differences = was=20 calculated using the unpaired t test with repeated measures = of=20 StatView 5.0. p < 0.05 was regarded as significant.

    Results
    3DResults=20 = = =

    Cellular = sensitivity of=20 glioblastoma cells to SN-38, NK012 and CPT-11

    The IC50 values of NK012 for the cell lines ranged = from=20 0.0087 mol/l=20 (U251MG cells) to 0.36 mol/l = (LN229=20 cells). The growth inhibitory effects of NK012 were 34- to = 444-fold more=20 potent than those of CPT-11, 400- to 12818-fold more potent than = those of=20 ACNU, 52-to 523-fold more potent than those of CDDP, and 3- to = 278-fold=20 more potent than those of etoposide. On the other hand, the=20 IC50 values of NK012 were almost similar to those of = SN-38=20 (Table. I).=20

     
    Table I. IC50 Values = of SN-38,=20 NK012, CPT-11, ACNU, CDDP and VP-16 in Various Human = Glioblastoma=20 Cell Lines
    Cell = line IC50(mol/l)
    SN38 NK012 CPT-11 ACNU CDDP Etoposide
    LN18 0.052 =B1 0.0034 0.069 =B1 0.0242 13.0 =B1 0.88 729 =B1 30 3.57 =B1 0.08 3.84 =B1 0.14
    LN229 0.28 =B1 0.1094 0.36 =B1 0.0489 12.2 =B1 1.23 144 =B1 23 21.4 =B1 0.62 0.945 =B1 = 0.025
    U87MG 0.18 =B1 0.0216 0.093 =B1 0.0038 18.1 =B1 3.06 865 =B1 86 9.06 =B1 0.57 20.8 =B1 5.23
    U118MG 0.0089 =B1 0.0003 0.022 =B1 0.0017 4.85 =B1 0.14 282 =B1 22 3.35 =B1 0.35 4.05 =B1 0.18
    U251MG 0.0076 =B1 0.0001 0.0087 =B1 0.0002 3.86 =B1 0.04 51.6 =B1 3.7 4.55 =B1 0.03 2.42 =B1=20 0.13
       Each cell line was = treated in=20 triplicate for 72 hr.
       WST-8 assay was used for = obtaining=20 IC50 = value.

    Antitumor = activity of NK012=20 and CPT-11 on subcutaneous U87MG/Luc xenografts

    Potent antitumor activity was observed in mice treated with = NK012 at 30=20 mg/kg in vivo (Fig. 1a).=20 In mice treated with NK012, tumor volume started to decrease on = day 5, and=20 the tumor completely disappeared by day 23, with no relapse = observed until=20 80 days after treatment. Although CPT-11 at 66.7 mg/kg/day exerted = antitumor activity compared with the control group, tumor volume = continued=20 to increase consistently. Comparison of the relative tumor volume = at day 8=20 revealed significant differences between the NK012-treated and=20 CPT-11-treated groups (p =3D 0.0095). Although = treatment-related body=20 weight loss was observed in mice treated with each drug, body = weight=20 recovery was observed by day 19 (Fig. 1b).=20 These results clearly show the significant in vivo activity = of=20 NK012 against the U87MG/Luc tumor xeonograft.=20

    Figure 1. Effects of = NK012 and=20 CPT-11 on U87MG/Luc tumor xenograft. (a) Tumor volume = in mice=20 treated with CPT-11 or NK012. U87MG/Luc tumor was = subcutaneously=20 inoculated into the flank of mice, as described in the Materials=20 and methods section. NaCl (0.9%) solution (),=20 CPT-11 at 66.7 mg/kg ()=20 and NK012 at 30 mg/kg ()=20 were intravenously administered on days 0, 4 and 8 (arrows). = Points,=20 mean; bars, SD. *p < 0.05. (b) = Treatment-related=20 body weight loss occurred in mice treated with CPT-11 and = NK012.=20 Points, mean; bars, SD.
    [Normal View 22K | = Magnified View=20 59K]

    Studies on = distribution of=20 NK012 and CPT-11 in orthotopic U87MG/Luc tumor tissues

    Both NK012 and CPT-11 formulations accumulated in the tumor = tissue but=20 not in the normal brain tissue (Fig. 2).=20 However, the drug distribution pattern was clearly different = between NK012=20 and CPT-11. In sections of the U87MG/Luc tumor treated with = CPT-11,=20 maximum drug accumulation was observed within 2 hr of CPT-11 = injection.=20 Twelve hours after the injection, fluorescence originating from = CPT-11 had=20 almost disappeared. Subsequently, no accumulation of CPT-11 was = observed=20 within the tumor tissues. However, in sections of the U87MG/Luc = tumor=20 treated with NK012, fluorescence from NK012 started appearing = around tumor=20 blood vessels 2 hr after intravenous injection and lasted until 24 = hr.=20 After 12 hr, the fluorescent area began to increase and the = maximum=20 fluorescence area was observed 24 hr after the injection.=20

    Figure 2. Distribution = of NK012=20 or CPT-11 in U87MG/Luc glioma xenografts. Mice bearing = U87MG/Luc=20 tumor were injected with NK012 (30 mg/kg/day) or CPT-11 = (66.7=20 mg/kg/day). Tumor tissues were excised 2, 12 and 24 hr after = the=20 intravenous injection of NK012 or CPT-11. Each mouse was=20 administered fluorescein-labeled Lycopersicon = esculentum=20 lectin 5 min before sacrifice to detect tumor blood vessels. = Frozen=20 sections were examined under a fluorescence microscope at an = excitation wavelength of 377 nm and an emission wavelength = of 477=20 nm. The same fluorescence conditions can be applied for = visualizing=20 NK012 and CPT-11 fluorescence. Free SN-38 could not be = detected=20 under these fluorescence conditions. The white lines = indicate the=20 border between the tumor and the brain tissue. T, U87MG/Luc = tumor;=20 B, normal brain tissue. (Scale bars: 20 m).
    [<= A=20 href=3D"javascript:display_fig002(0)">Normal View 52K | = Magnified View=20 283K]

    Pharmacokinetics = analysis of=20 NK012 and CPT-11 in mice bearing orthotopic U87MG/Luc = xenografts

    Microscopic observations were confirmed quantitatively by = measuring the=20 amount of SN-38 extracted from each solid tumor by reversed-phase = HPLC.=20 After CPT-11 injection, the concentrations of CPT-11 and free = SN-38 in=20 plasma decreased rapidly with time in a log-linear fashion. On the = other=20 hand, the plasma concentration of NK012 (polymer-bound SN-38) = showed=20 slower clearance than that of CPT-11. Free SN-38 released from = NK012 also=20 showed slow clearance than that of SN-38 converted from CPT-11 = (Fig. 3a).=20 Meanwhile, there was a significant difference in drug accumulation = in the=20 tumor between CPT-11 and NK012, that is, the accumulation of NK012 = in the=20 U87MG/Luc tumor was significantly higher than that of CPT-11 (Fig. = 3b)=20 and that the concentration of free SN-38 originating from NK012 = was=20 maintained at 24.6 ng/g even 72 hr after injection (Table II).=20 On the other hand, only slight conversion from CPT-11 to SN-38 was = observed from 2 to 24 hr in the U87MG/Luc tumor, and no SN-38 was = detected=20 thereafter (Fig. 3b).=20 This result suggests that the BTB of the tumor was partially = destroyed in=20 the tumor vasculature and both drugs extravasated from the tumor = blood=20 vessels. In addition, these results indicate that NK012 can remain = in the=20 tumor tissue for a longer period and continue to release free = SN-38.=20

    Figure 3. Plasma, = brain tissue=20 and orthotopic tumor concentrations of respective analytes = after=20 intravenous administration of NK012 (30 mg/kg/day) and = CPT-11 (66.7=20 mg/kg/day) to U87MG/Luc-bearing nude mice. (a) = plasma;=20 (b) tumor. ,=20 polymer-bound SN-38; ,=20 free SN-38 (polymer-unbound SN-38); ,=20 CPT-11; ,=20 free SN-38 converted from CPT-11.
    [Normal View 22K | = Magnified View=20 59K]
     
    Table II. Tumor and Plasma = Concentration=20 of SN38 After an I.V. Administration of NK012 (30 mg/kg) and = CPT-11=20 (66.7mg/kg) to Nude Mice Bearing U87MG/Luc Brain = Tumor
    Formulation = tested Analyte Time = after=20 administration (hr)
    2 12 24 72
    NK012 Free = SN-38 Plasma (ng/ml) 1113 511 90.0 6.88
    Tumor (ng/g) 67.7 84.1 137 24.6
    CPT-11 Free SN-38 = 5 Plasma (ng/ml) 62.0 4.74 1.97 ND
    Tumor (ng/g) 31.8 7.41 2.14 ND
       Data were expressed as = means of=20 three mice.
       Free = SN-38;=20 SN-38 released from NK012 or converted from = CPT-11.
       ND, not=20 detectable.

    Antitumor = activity of NK012=20 and CPT-11 against orthotopic U87MG/Luc glioma = xenografts

    Antitumor activity was observed in mice treated with NK012 at = 30=20 mg/kg/day and CPT-11 at 66.7 mg/kg/day in vivo (Fig. 4a).=20 ANOVA analysis revealed a significant difference between the = control group=20 and the NK012-treated group (p =3D 0.02). However there was = no=20 significant difference between the control group and the = CPT-11-treated=20 group (p =3D 0.23) and between NK012 and CPT-11 (p = =3D 0.21)=20 (Fig. 4b).=20 Comparison of the relative tumor volume at day 14 revealed = significant=20 differences between NK012 (30 mg/kg/day) and CPT-11 (66.7 = mg/kg/day)=20 (p =3D 0.049). Kaplan-Meier analysis showed that a = significant=20 improvement in survival rate was observed in the NK012 treatment = group=20 compared with the control (p =3D 0.001) and CPT-11 = treatment groups=20 (p =3D 0.0014) (Fig. 4c).=20

    Figure 4. Antitumor = effect of=20 NK012 or CPT-11 on orthotopic xenograft and survival. Mice = receiving=20 intracranial injections of U87MG/Luc were assigned into = groups 20=20 days after tumor inoculation. Mice were intravenously = administered=20 with 0.9% NaCl solution (),=20 NK012 (30 mg/kg/day, )=20 or CPT-11 (66.7 mg/kg/day, ) on=20 days 0 (20 days after tumor inoculation), 4 and 8 (arrows).=20 (a) Representative luminescence intensity images = obtained in=20 individual control and treatment-group mice on the days = indicated.=20 (b) Antitumor effect of NK012 or CPT-11 on days 14, = 21 and=20 28. Each group consisted of 4 mice. Points, mean; bars, SD.=20 *p < 0.05. (c) Treatment effects of NK012 = on=20 survival. Survival was assessed by Kaplan-Meier analysis. = Each group=20 consisted of 6 mice. Experiments were repeated twice with = similar=20 results.
    [Normal = View=20 39K | Magnified = View=20 114K]

    Discussion
    3DDiscussion=20 = =

    The diameter of a micelle carrier is approximately in the range = of=20 10-100 nm, which is smaller than that of a liposome. Although this = size is=20 small, it is still sufficiently large to prevent renal secretion = of the=20 carrier. The micelle systems can evade nonspecific capture by the=20 reticuloendothelial system in various organs because the outer = shell of=20 the micelle is covered with polyethyleneglycol. Therefore,=20 drug-incorporating micelles can be expected to have a long plasma=20 half-life, which permits a large amount of the micelles to reach = tumor=20 tissues, extravasate from tumor capillaries, and then be retained = in tumor=20 tissues for a long time by utilizing the enhanced permeability and = retention (EPR) effect.[22]

    Several factors are reportedly involved in vascular = permeability in the=20 body. Among them, bradykinin is the most potent vascular = permeability=20 factor. We succeeded in purifying 2 types of kinin from the = ascitic fluid=20 of a patient with gastric cancer.[23]=20 We also clarified that this kinin generation system was triggered = by the=20 activated Hageman factor, an intrinsic coagulation factor XII.[24]=20 Meanwhile, Dvorak et al. discovered that the vascular permeability = factor=20 (VPF) is involved in tumor vascular permeability.[25]=20 Later, it was found that VPF was identical to VEGF.[26]=20 Recently, an extrinsic coagulation factor, namely, a tissue = factor, has=20 been shown to activate VEGF production.[27][28]=20 Thus, both intrinsic and extrinsic coagulation factors may be = involved in=20 tumor vascular permeability. Furthermore, there have been several = reports=20 to date indicating the increasing expression of a tissue factor in = human=20 glioma.[29][30]=20 Also, it is well known that glioma is a typical hypervascular = tumor with=20 an irregular vascular architecture and a high expression level of = VEGF.[31]=20 Therefore, it may be speculated that nanoparticles extravasate = from tumor=20 capillaries and accumulate more preferentially in brain = glioma.

    NK012, an SN-38-incorporating polymeric micelle, is a novel = type of=20 micellar formulation with long-time accumulation in tumors, and = shows=20 prolonged sustained release of SN-38 within the tumor.[17][20]=20 We have thus far reported that NK012 shows significantly higher = antitumor=20 activity against various human tumor xenografts including small = cell lung=20 cancer,[17]=20 colorectal cancer,[19]=20 renal cancer,[18]=20 and pancreatic cancer[20]=20 compared with CPT-11. In addition, we have recently seen an = increasing=20 number of reports of clinical trials indicating the effectiveness = of=20 CPT-11 against brain glioma in combination with anti-VEGF = antibody[11][12][32][33]

    Under these circumstances, it may be reasonable to conduct an=20 investigation into the advantages of administering NK012 over = CPT-11 for=20 treatment against human glioma tumor xenografts. In the present = study, we=20 showed that NK012 exerted a significant antitumor activity in = U87MG/Luc=20 subcutaneous xenografts (Fig. 1).=20 In the tumor intravenously administered with NK012 (30 mg/kg), = NK012=20 accumulated within and around tumor blood vessels in the = orthotopic=20 xenografts 2 hr after the injection. Thereafter, NK012 started to = spread=20 from the blood vessel within the tumor tissue of the xenografts.=20 Fluorescence originating from NK012 then increased up to the = maximum in=20 the entire tumor by 24 hr after NK012 injection. On the other = hand,=20 fluorescence originating from CPT-11 increased up to the maximum 2 = hr=20 after its injection, indicating that the maximum distribution of = CPT-11=20 was achieved within 2 hr of injection. Twelve hours after = intravenous=20 injection, fluorescence from CPT-11 had almost disappeared, and=20 subsequently, no accumulation of CPT-11 was observed within the = tumor=20 tissues. The therapeutic effect of NK012 was superior to that of = CPT-11 in=20 terms of antitumor effect and survival. Because the antitumor = activity of=20 SN-38 is time-dependent, the superiority of NK012 over CPT-11 may = be due=20 to the enhanced accumulation of NK012 and the prolonged sustained = release=20 of SN-38 from NK012 within the tumor tissues. Nevertheless, free = SN-38 was=20 not detected in the normal brain tissues at any measurement time = after=20 intravenous injection of NK012 or CPT-11 (data not shown). It is = thus=20 speculated that both NK012 and CPT-11 are unable to cross the BBB = in the=20 normal brain, but can pass through tumor vessels effectively. In = clinical=20 brain glioma, however, when the tumor recurs, it would most likely = recur=20 in adjacent regions of the brain with an intact blood brain = barrier.=20 Namely, at the border between the brain tumor and normal brain = tissue,=20 malignant glioma cells and normal brain tissues intermix in the = gradient=20 and angiogenesis occurs at sites where there are large = accumulation of=20 tumor cells under local hypoxia.[34]=20 In addition, there is no clear evidence if tumor vessels of = orthotopic=20 brain tumor xenografts are identical to those of real human brain = tumors=20 in terms of their structure and function. Therefore, it may be = better to=20 consider to conduct an investigation of the advantages of = administering=20 some anti-angiogenic inhibitors in combination with NK012 against = highly=20 invasive tumor models established by several methods such as = direct=20 implantation of patient surgical specimens into the brains of nude = mice,[35]=20 transplantation of patient surgical material s.c. in nude mice = followed by=20 dissociation and orthotopic reinjection of these = xenotransplants,[36]=20 engraftment of glioblastoma-derived spheroids after short- term = culture=20 into rat brain,[37]=20 and engraftment of glioblastomastem cell-enriched cultures into = mouse=20 brain.[38][39]

    The dose-limiting toxicities of CPT-11 appeared to be = neutropenia and=20 diarrhea. However, in our previous data, there was no significant=20 difference in the level of SN-38 in the small intestine between=20 NK012-treated and CPT-11-treated mice.[17]=20 It was also reported that NK012 showed significant antitumor = effect with=20 diminishing incidence of diarrhea compared with CPT-11.[40]=20 In 2 individual phase 1 trials in Japan and the US, no serious = diarrhea=20 has been reported.[41][42]=20 In addition, one confirmed partial response (PR) was obtained in a = patient=20 with metastatic esophageal cancer in a Japanese trial,[41]=20 and 3 PRs in a patient with breast cancer and 1 PR in a patient = with small=20 cell lung cancer in a US phase 1 trial.[42]

    In conclusion, we demonstrated not only the enhanced = accumulation,=20 distribution, and retention of NK012 within glioma xenografts but = also the=20 superiority of the antitumor activity of NK012 compared with = CPT-11.=20 Taking the present data together with very recent clinical data = from phase=20 1 trials, a phase 2 trial in patients with recurrent glioma may be = warranted.

    Acknowledgements
    3DAcknowledgements=20 =

    The authors thank Ms. N. Mie, Ms. H. Miyatake and Ms. M. Ohtsu = for=20 their technical assistance and Ms. K. Shiina for her secretarial=20 assistance.

    References
    3DReferences=20
    1 DeAngelis LM. Brain tumors. N Engl J = Med=20 2001; 344: 114-23.
    2 Kleihues P,Louis DN,Scheithauer BW,Rorke=20 LB,Reifenberger G,Burger PC,Cavenee WK. The WHO = classification of=20 tumors of the nervous system. J Neuropathol Exp = Neurol 2002;=20 61: 215-25 discussion 26-9. =
    3 Stupp R,Mason WP,van den Bent MJ,Weller = M,Fisher=20 B,Taphoorn MJ,Belanger K,Brandes AA,Marosi C,Bogdahn = U,Curschmann=20 J,Janzer RC, et al. Radiotherapy plus concomitant and = adjuvant=20 temozolomide for glioblastoma. N Engl J Med 2005; = 352:=20 987-96.
    4 Wong ET,Hess KR,Gleason MJ,Jaeckle = KA,Kyritsis=20 AP,Prados MD,Levin VA,Yung WK. Outcomes and prognostic = factors in=20 recurrent glioma patients enrolled onto phase II clinical = trials.=20 J Clin Oncol 1999; 17: 2572-8.
    5 Li LH,Fraser TJ,Olin EJ,Bhuyan BK. Action = of=20 camptothecin on mammalian cells in culture. Cancer = Res 1972;=20 32: 2643-50.
    6 Gallo RC,Whang-Peng J,Adamson RH. Studies = on the=20 antitumor activity, mechanism of action, and cell cycle = effects of=20 camptothecin. J Natl Cancer Inst 1971; 46: = 789-95.
    7 Friedman HS,Petros WP,Friedman AH,Schaaf = LJ,Kerby=20 T,Lawyer J,Parry M,Houghton PJ,Lovell S,Rasheed K,Cloughsey=20 T,Stewart ES, et al. Irinotecan therapy in adults with = recurrent or=20 progressive malignant glioma. J Clin Oncol 1999; = 17:=20 1516-25.
    8 Cloughesy TF,Filka E,Kuhn J,Nelson = G,Kabbinavar=20 F,Friedman H,Miller LL,Elfring GL. Two studies evaluating = irinotecan=20 treatment for recurrent malignant glioma using an = every-3-week=20 regimen. Cancer 2003; 97: 2381-6.
    9 Chamberlain MC. Salvage chemotherapy with = CPT-11=20 for recurrent glioblastoma multiforme. J Neurooncol = 2002;=20 56: 183-8.
    10 Prados MD,Lamborn K,Yung WK,Jaeckle = K,Robins=20 HI,Mehta M,Fine HA,Wen PY,Cloughesy T,Chang S,Nicholas = MK,Schiff D,=20 et al. A phase 2 trial of irinotecan (CPT-11) in patients = with=20 recurrent malignant glioma: a North American brain tumor = consortium=20 study. Neuro Oncol 2006; 8: 189-93.
    11 Vredenburgh JJ,Desjardins A,Herndon JE, = II,Dowell=20 JM,Reardon DA,Quinn JA,Rich JN,Sathornsumetee S,Gururangan = S,Wagner=20 M,Bigner DD,Friedman AH, et al. Phase II trial of = bevacizumab and=20 irinotecan in recurrent malignant glioma. Clin Cancer = Res=20 2007; 13: 1253-9.
    12 Vredenburgh JJ,Desjardins A,Herndon JE,=20 II,Marcello J,Reardon DA,Quinn JA,Rich JN,Sathornsumetee=20 S,Gururangan S,Sampson J,Wagner M,Bailey L, et al. = Bevacizumab plus=20 irinotecan in recurrent glioblastoma multiforme. J Clin = Oncol=20 2007; 25: 4722-9.
    13 Gradishar WJ. Albumin-bound nanoparticle=20 paclitaxel. Clin Adv Hematol Oncol 2005; 3: = 348-9.
    14 Muggia FM. Liposomal encapsulated = anthracyclines:=20 new therapeutic horizons. Curr Oncol Rep 2001; = 3:=20 156-62.
    15 Slatter JG,Schaaf LJ,Sams JP,Feenstra = KL,Johnson=20 MG,Bombardt PA,Cathcart KS,Verburg MT,Pearson LK,Compton = LD,Miller=20 LL,Baker DS, et al. Pharmacokinetics, metabolism, and = excretion of=20 irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 = in=20 cancer patients. Drug Metab Dispos 2000; 28: = 423-33.
    16 Rothenberg ML,Kuhn JG,Burris HA, = III,Nelson=20 J,Eckardt JR,Tristan-Morales M,Hilsenbeck SG,Weiss GR,Smith=20 LS,Rodriguez GI, et al. Phase I and pharmacokinetic trial of = weekly=20 CPT-11. J Clin Oncol 1993; 11: 2194-204.
    17 Koizumi F,Kitagawa M,Negishi T,Onda = T,Matsumoto=20 S,Hamaguchi T,Matsumura Y. Novel SN-38-incorporating = polymeric=20 micelles, NK012, eradicate vascular endothelial growth=20 factor-secreting bulky tumors. Cancer Res 2006; = 66:=20 10048-56.
    18 Sumitomo M,Koizumi F,Asano T,Horiguchi = A,Ito=20 K,Kakizoe T,Hayakawa M,Matsumura Y. Novel SN-38-incorporated = polymeric micelle, NK012, strongly suppresses renal cancer=20 progression. Cancer Res 2008; 68: 1631-5.
    19 Nakajima TE,Yasunaga M,Kano Y,Koizumi = F,Kato=20 K,Hamaguchi T,Yamada Y,Shirao K,Shimada Y,Matsumura Y. = Synergistic=20 antitumor activity of the novel SN-38-incorporating = polymeric=20 micelles, NK012, combined with 5-fluorouracil in a mouse = model of=20 colorectal cancer, as compared with that of irinotecan plus=20 5-fluorouracil. Int J Cancer 2008; 122: = 2148-53.
    20 Saito Y,Yasunaga M,Kuroda J,Koga = Y,Matsumura Y.=20 Enhanced distribution of NK012, a polymeric = micelle-encapsulated=20 SN-38, and sustained release of SN-38 within tumors can beat = a=20 hypovascular tumor. Cancer Sci 2008; 99: = 1258-64.
    21 Kawato Y,Furuta T,Aonuma M,Yasuoka = M,Yokokura=20 T,Matsumoto K. Antitumor activity of a camptothecin = derivative,=20 CPT-11, against human tumor xenografts in nude mice. = Cancer=20 Chemother Pharmacol 1991; 28: 192-8.
    22 Matsumura Y,Maeda H. A new concept for=20 macromolecular therapeutics in cancer chemotherapy: = mechanism of=20 tumoritropic accumulation of proteins and the antitumor = agent=20 smancs. Cancer Res 1986; 46: 6387-92.
    23 Maeda H,Matsumura Y,Kato H. Purification = and=20 identification of [hydroxyprolyl3]bradykinin in ascitic = fluid from a=20 patient with gastric cancer. J Biol Chem 1988; = 263:=20 16051-4.
    24 Matsumura Y,Maruo K,Kimura M,Yamamoto = T,Konno=20 T,Maeda H. Kinin-generating cascade in advanced cancer = patients and=20 in vitro study. Jpn J Cancer Res 1991; 82: = 732-41.
    25 Dvorak HF,Nagy JA,Dvorak JT,Dvorak AM.=20 Identification and characterization of the blood vessels of = solid=20 tumors that are leaky to circulating macromolecules. Am J = Pathol 1988; 133: 95-109.
    26 Leung DW,Cachianes G,Kuang WJ,Goeddel = DV,Ferrara=20 N. Vascular endothelial growth factor is a secreted = angiogenic=20 mitogen. Science 1989; 246: 1306-9.
    27 Abe K,Shoji M,Chen J,Bierhaus A,Danave = I,Micko=20 C,Casper K,Dillehay DL,Nawroth PP,Rickles FR. Regulation of = vascular=20 endothelial growth factor production and angiogenesis by the = cytoplasmic tail of tissue factor. Proc Natl Acad Sci = USA=20 1999; 96: 8663-8.
    28 Belting M,Dorrell MI,Sandgren S,Aguilar = E,Ahamed=20 J,Dorfleutner A,Carmeliet P,Mueller BM,Friedlander M,Ruf W.=20 Regulation of angiogenesis by tissue factor cytoplasmic = domain=20 signaling. Nat Med 2004; 10: 502-9.
    29 Rong Y,Post DE,Pieper RO,Durden DL,Van = Meir=20 EG,Brat DJ. PTEN and hypoxia regulate tissue factor = expression and=20 plasma coagulation by glioblastoma. Cancer Res 2005;=20 65: 1406-13.
    30 Hamada K,Kuratsu J,Saitoh Y,Takeshima = H,Nishi=20 T,Ushio Y. Expression of tissue factor correlates with grade = of=20 malignancy in human glioma. Cancer 1996; 77: = 1877-83.
    31 Takano S,Yoshii Y,Kondo S,Suzuki H,Maruno = T,Shirai=20 S,Nose T. Concentration of vascular endothelial growth = factor in the=20 serum and tumor tissue of brain tumor patients. Cancer = Res=20 1996; 56: 2185-90.
    32 Chowdhary S,Wong ET. Bevacizumab combined = with=20 irinotecan for recurrent glioblastoma multiforme-improvement = over=20 available therapy? Nat Clin Pract Neurol 2008; = 4:=20 242-3.
    33 Chamberlain MC Bevacizumab plus irinotecan = in=20 recurrent glioblastoma. J Clin Oncol 2008; 26: = 1012-3.
    34 Plate KH,Breier G,Weich HA,Risau W. = Vascular=20 endothelial growth factor is a potential tumour angiogenesis = factor=20 in human gliomas in vivo. Nature 1992; 359: = 845-8.
    35 Horten BC,Basler GA,Shapiro WR. Xenograft = of human=20 malignant glial tumors into brains of nude mice. A = histopatholgical=20 study. J Neuropathol Exp Neurol 1981; 40: = 493-511.
    36 Giannini C,Sarkaria JN,Saito A,Uhm = JH,Galanis=20 E,Carlson BL,Schroeder MA,James CD. Patient tumor EGFR and = PDGFRA=20 gene amplifications retained in an invasive intracranial = xenograft=20 model of glioblastoma multiforme. Neuro Oncol 2005; = 7:=20 164-76.
    37 Engebraaten O,Hjortland GO,Hirschberg = H,Fodstad O.=20 Growth of precultured human glioma specimens in nude rat = brain. J=20 Neurosurg 1999; 90: 125-32.
    38 Galli R,Binda E,Orfanelli U,Cipelletti = B,Gritti=20 A,De Vitis S,Fiocco R,Foroni C,Dimeco F,Vescovi A. Isolation = and=20 characterization of tumorigenic, stem-like neural precursors = from=20 human glioblastoma. Cancer Res 2004; 64: = 7011-21.
    39 Gunther HS,Schmidt NO,Phillips HS,Kemming=20 D,Kharbanda S,Soriano R,Modrusan Z,Meissner H,Westphal = M,Lamszus K.=20 Glioblastoma-derived stem cell-enriched cultures form = distinct=20 subgroups according to molecular and phenotypic criteria.=20 Oncogene 2008; 27: 2897-909.
    41 Kato K,Hamaguchi T,Shirao K,Shimada Y,Doi = T,Ohtsu=20 A,Matsumura Y,Yamada Y. Interim analysis of phase I study of = NK012,=20 polymer micelle SN-38, in patients with advanced cancer. = Proc Am=20 Soc Clin Oncol GI 2008 (Abstract no 485).
    42 Burris HA, III,Infante JR,Spigel DR,Greco=20 FA,Thompson DS,Matsumoto S,Kawamura S,Jones SF. A phase I=20 dose-escalation study of NK012. Proc Am Soc Clin = Oncol 2008=20 (Abstract no 2538).

    3D""=20
    ------=_NextPart_000_0000_01C99F0E.BB8D06B0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/blank.html UNTITLED_PAGE= ------=_NextPart_000_0000_01C99F0E.BB8D06B0--