From: Subject: Asymmetric centrosome behavior and the mechanisms of stem cell division -- Yamashita and Fuller 180 (2): 261 -- The Journal of Cell Biology Date: Wed, 30 Jan 2008 18:03:16 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_002F_01C8636A.6351FD60" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.jcb.org/cgi/content/full/180/2/261?ijkey=e3ee3617249291da9799a4beb455cfe2982b4f43 Asymmetric centrosome behavior and the mechanisms of = stem cell division -- Yamashita and Fuller 180 (2): 261 -- The Journal = of Cell Biology
3D"JCB
  Home | Help | Feedback |=20 Subscriptions | = Archive | = Search | Table of = Contents=20
Published online 21 January=20 2008
doi:10.1083/jcb.200707083
The Journal of Cell = Biology, Vol.=20 180, No. 2, 261-266
=A9 The=20 Rockefeller University Press, 0021-9525 $30.00
This = Article
3D"
3D"Right Abstract=20 3D"Freely
3D"Right PDF=20 (Full Text)
3D"Right Alert=20 me when this article is cited
3D"
Services
3D"
3D"Right Email=20 this article
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in PubMed
3D"Right Alert me to new = content in=20 the JCB
3D"Right Download to=20 citation manager
3D"
Citing = Articles
3D"
3D"Right Citing=20 Articles via HighWire
3D"Right Citing Articles via CrossRef =
3D"
Google = Scholar
3D"
3D"Right Articles by Yamashita, Y. M. =
3D"Right Articles by Fuller, M. T. =
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Yamashita, Y. M. =
3D"Right Articles by Fuller, M. T. =
3D"
Related = Collections
3D"
3D"Right Related=20 Article
3D"
Social = Bookmarking
3D"
3D"                     
What's = this?=20

Mini-Review

Asymmetric = centrosome=20 behavior and the mechanisms of stem cell division

Yukiko M.=20 Yamashita1,2 and Margaret T.=20 Fuller3,4

1 Center for Stem = Cell=20 Biology, Life Sciences Institute, and 2 Department of Cell = and=20 Developmental Biology, University of Michigan, Ann Arbor, MI=20 48109
3 Department of Developmental Biology and = 4=20 Department of Genetics, Stanford University School of Medicine, = Stanford, CA=20 94305

Correspondence to Yukiko M. = Yamashita: yukikomy{at}umich.edu ; or Margaret T. Fuller: mtfuller{at}stanford.edu

The ability of dividing cells to produce = daughters with=20 different fates is an important developmental mechanism = conserved=20 from bacteria to fungi, plants, and metazoan animals. = Asymmetric=20 outcomes of a cell division can be specified by two general=20 mechanisms: asymmetric segregation of intrinsic fate = determinants=20 or asymmetric placement of daughter cells into = microenvironments=20 that provide extrinsic signals that direct cells to different = states. For both, spindle orientation must be coordinated = with=20 the localization of intrinsic determinants or source of = extrinsic=20 signals to achieve the proper asymmetric outcome. Recent work = on spindle orientation in Drosophila melanogaster male=20 germline stem cells and neuroblasts has brought into sharp = focus=20 the key role of differential centrosome behavior in=20 developmentally programmed asymmetric division (for reviews = see Cabernard,=20 C., and C.Q. Doe. 2007. Curr. Biol. = 17:R465=96R467; Gonzalez,=20 C. 2007. Nat. Rev. Genet. 8:462=96472). These = findings=20 provide new insights and suggest intriguing new models for = how cells=20 coordinate spindle orientation with their cellular = microenvironment=20 to regulate and direct cell fate decisions within = tissues.=20

Abbreviations used in=20 this paper: APC, adenomatous polyposis coli; GMC, ganglion = mother=20 cell; GSC, germline stem cell; MTOC, microtubule-organizing = center;=20 SPB, spindle pole body.

The essential stem cell question: to renew or = not to=20 renew
Adult stem cells maintain many short-lived but = highly=20 differentiated cell types, including cells of the blood, = skin, lining=20 of the intestine and colon, and sperm. Although normally=20 specialized to produce particular cell types, adult stem = cells are=20 relatively undifferentiated cells that retain their ability = to keep=20 dividing and to produce fully differentiated cells throughout = adult=20 life. When stem cells divide, their daughters either = self-renew=20 stem cell identity or initiate differentiation. The balanced=20 choice between these alternate fates is critical both to = maintain=20 stem cell numbers and to rein in their potentially dangerous=20 capacity for long-term proliferation.

A stem cell can divide asymmetrically, producing exactly one = stem=20 cell and one differentiating cell to maintain the tissue in a = homeostatic state, or symmetrically, producing two stem = cells. The=20 latter is an important mechanism for stem cell expansion = during=20 embryonic development and replacement of stem cells after = injury (for=20 review see Morrison=20 and Kimble, 2006). Recent studies have illuminated the = importance=20 of the stem cell microenvironment, or niche, as a source of = local=20 extrinsic signals that specify stem cell self-renewal (for = reviews=20 see Spradling=20 et al., 2001; Fuchs=20 et al., 2004). In the context of this niche, developmentally=20 regulated orientation of the mitotic spindle directs whether=20 the outcome of a stem cell division is asymmetric or = symmetric.=20 When the spindle is oriented perpendicular to the interface=20 with the niche, upon cell cleavage, one daughter can maintain = contact with the niche while the other is displaced away and = is=20 free to initiate differentiation. In contrast, spindle orientation=20 parallel to the interface with the niche can allow both = daughters=20 to inherit attachments to and receive local self-renewal = signals=20 from the niche. Such relationships between spindle = orientation=20 and asymmetric/symmetric stem cell division have been = observed=20 in many systems, including mammalian skin (Lechler=20 and Fuchs, 2005), muscle (Kuang=20 et al., 2007), and neuronal stem cells (Estivill-Torrus=20 et al., 2002), and appear to be broadly used to = accomplish=20 asymmetric stem cell divisions.

Spindle reorientation or permanent cell = polarity: two=20 routes to an oriented cell division
Cells use two = different=20 types of strategies to orient the division plane with respect = to=20 intrinsic or extrinsic asymmetry cues. Cells can maintain a = fixed=20 orientation throughout the cell cycle so that proper spindle=20 orientation is predetermined before cells enter mitosis.=20 Alternatively, cells can first assemble the mitotic spindle = at a=20 different angle and then undergo programmed spindle rotation = to=20 acquire the desired orientation by metaphase. The programmed = rotation=20 strategy may be especially advantageous in cases in which = cells=20 switch between symmetric versus asymmetric divisions (for = example,=20 under developmental control or in response to injury). = However, with=20 such flexibility, the option for a symmetric outcome must be=20 carefully controlled lest it allow the undesired = proliferation of=20 stem cells, which may perturb orchestrated tissue=20 development/maintenance. In contrast, stem cell systems that = use the=20 fixed orientation mechanism may be more resistant to = tumorgenesis but=20 more limited in capacity to expand stem cell number for = replenishment=20 or repair.

Germline stem cells: oriented division within = a stem=20 cell niche
Male and female germline stem cells (GSCs) = in=20 Drosophila melanogaster provide some of the = best-understood=20 examples of asymmetric stem cell divisions in vivo in the = context of=20 their niche. Drosophila GSCs are physically attached = via=20 adherens junctions to somatic niche cells that secrete = signaling=20 ligands that specify stem cell identity in the neighboring = germ=20 cells. In females, somatic cap cells at the tip of each = ovariole=20 secrete TGFβ-class ligands that maintain nearby germ = cells in the=20 stem cell state. Activation of the TGFβ signal = transduction pathway=20 directly represses transcription of a key differentiation = gene,=20 bam, in GSCs (Chen=20 and McKearin, 2003a,b).=20 In males, somatic hub cells located at the apical tip of the = testis=20 provide the niche by secreting the ligand Upd, which = activates the=20 JAK=96STAT (Janus kinase=96signal transducer and activator of = transcription) signal transduction pathway within the GSCs,=20 preventing stem cells from differentiating (Fig.=20 1 A ; Kiger=20 et al., 2001; Tulina=20 and Matunis, 2001).



View = larger=20 version (31K):
[in this=20 window]
[in a new window]
[Download=20 PPT slide]
  		Figure 1.=20 Asymmetric centrosome/SPB behavior during asymmetric cell = divisions. (A) Structure of the stem cell niche in the=20 Drosophila male germline. Somatic hub cells are the = major=20 components of the niche for male GSCs. The GSC attaches to = the hub=20 via adherens junction (red lines) so that it can receive the = signaling ligand, Upd, from the hub (yellow allow) to = activate the=20 JAK=96STAT (Janus kinase=96signal transducer and activator = of=20 transcription) pathway. The stem cell daughter that is = displaced=20 away from the hub (gonialblast; GB) starts differentiation. = (B)=20 Consistent centrosome positioning orients the mitotic = spindle in=20 male GSCs. The mother centrosome (red dots) is always = located close=20 to the hub, whereas the daughter (yellow dots) migrates = toward the=20 opposite side of the cell to set up orientation of the = mitotic=20 spindle. (C) Asymmetric division of the Drosophila = neuroblast=20 (NB). The neuroblast divides asymmetrically by segregating = fate=20 determinants. Apical protein complexes (red lines) include = Par6,=20 Baz, and atypical PKC, and basal fate determinants (blue = lines)=20 include Numb, Miranda, and Prospero (for a more = comprehensive set of=20 asymmetrically localized proteins, see the review Yu=20 et al., 2006). (D) Consistent centrosome behavior = orients the=20 mitotic spindle in the neuroblast. The apical centrosome = (large red=20 dots) retains MTOC activity throughout the cell cycle, = whereas the=20 other centrosome (small red dots) becomes active only at the = G2-M=20 transition. The inactive centrosome migrates toward the = basal side=20 during interphase. Pins might be functioning to provide a = cortical=20 cue to anchor active MTOC. (E) Spindle orientation in = budding yeast.=20 The mother SPB is normally delivered to the bud cell, where = it is=20 captured by the bud tip cortex. This process is mediated by = astral=20 microtubules emanating from the mother SPB and Kar9 protein. = Cell=20 cycle regulators such as Tem1 and Bub2/Bfa1 are specifically = localized to the bud-directed SPB (normally the mother SPB) = to=20 coordinate spindle position and cell cycle progression. =

 
In=20 both sexes, the mitotic spindle is normally oriented perpendicular = to=20 the interface with the niche so that one daughter of each GSC = division inherits the adherens junctions and retains close = contact=20 with the niche and its sustaining signals, whereas the other = normally=20 loses contact with the niche and initiates differentiation. = The=20 mitotic spindle is normally perpendicular to the niche when = it is=20 initially set up and does not rotate to acquire the desired=20 orientation. In male GSCs, centrosomes are oriented with = respect=20 to the niche throughout the cell cycle, preparing the = orientation=20 of mitotic spindle (Fig.=20 1 B; Yamashita=20 et al., 2003). Female GSCs appear to use the spectrosome, = a=20 membrane-rich subcellular organelle, to orient the spindle = (Deng=20 and Lin, 1997).

Neuroblasts: asymmetric inheritance of = intrinsic=20 determinants
Drosophila neuroblasts provide = one of the=20 most well-understood examples of tissue-renewing cells that = undergo=20 asymmetric division based on differential segregation of = intrinsic=20 fate determinants (Fig.=20 1 C). In Drosophila embryos and larvae, neuroblasts of = the=20 central nervous system undergo a series of asymmetric divisions, = each=20 generating a new neuroblast and a ganglion mother cell (GMC), = which=20 divides once more and then differentiates. Key determinants = that=20 regulate differentiation are localized to the basal cortex of = the=20 neuroblast before cell division and, as a result of an = apicobasally=20 oriented and asymmetrically positioned mitotic spindle, are=20 sequestered into the nascent GMC (for review see Yu=20 et al., 2006).

Asymmetric localization of fate determinants to the basal cortex = depends on an evolutionally conserved mechanism based on the=20 Par6, Baz (Par3), and atypical PKC cell polarity complex, = which=20 localizes to the apical side of the neuroblast cortex before=20 division. The apical Par complex also serves as a binding = platform=20 for proteins that control orientation and positioning of the=20 mitotic spindle. Coordination of the position of cell fate=20 determinants with spindle orientation (which depends on Pins = and G=20 protein signaling) means that determinants localized to the = basal=20 cortex of the dividing neuroblast are reliably inherited into = the=20 GMC, where they promote differentiation. Live cell imaging of = embryonic neuroblasts revealed that the cell polarity = complex,=20 interphase centrosome, and spindle are all oriented with = respect to=20 extrinsic cues from contact with epithelial cells. Although = the=20 centrosome maintains position near the interface with the = epithelial=20 cells throughout much of interphase, in approximately half of = the early embryonic neuroblasts observed, the centrosomes = leave=20 this position when they separate and move to the opposite = sides=20 of the nucleus in prophase. As a result, when the spindle is=20 initially set up, it is not oriented along the axis of = neuroblast=20 asymmetry but reorients to the proper position before the=20 metaphase-anaphase transition (Kaltschmidt=20 et al., 2000; Siegrist=20 and Doe, 2006).

Separate but not equal = centrosomes
In=20 contrast to the programmed rotation of the spindle in embryonic=20 neuroblasts, spindles are normally properly oriented at the=20 time that they are set up in larval neuroblasts in the = central=20 nervous system as in Drosophila GSCs. Larval brain = neuroblasts=20 maintain a consistent orientation through many cell cycles so = that new GMCs emerge next to those produced during previous=20 cell cycles. In a developmentally programmed specialized = centrosome=20 cycle, one of the two centrosomes retains = microtubule-organizing=20 center (MTOC) activity and a robust astral microtubule array=20 during interphase and remains close to the apical cortex. = Meanwhile,=20 the other centrosome loses MTOC activity and wanders actively = throughout the apical half of the cell (Fig.=20 1 D). Later in the cell cycle, the inactive centrosome = moves to=20 the basal side of the cell, where it regains MTOC activity by = the=20 onset of mitosis (Rebollo=20 et al., 2007; Rusan=20 and Peifer, 2007).

In a striking parallel, differential behavior of the two = centrosomes=20 during interphase also appears to underlie the stereotyped=20 orientation of the spindle in Drosophila male GSCs. = Early in=20 interphase, the single centrosome in each male GSC is located = close=20 to the interface with the stem cell niche. After centrosome=20 duplication, one centrosome maintains a robust array of = astral=20 microtubules throughout the cell cycle and stays close to the = niche,=20 whereas the other migrates away, setting up the future=20 perpendicular orientation of the mitotic spindle (Yamashita=20 et al., 2007). The centrosome that migrates to the = opposite side=20 of the nucleus is associated with few microtubules until late = in the=20 cell cycle, when it appears to resume MTOC activity. The = separation=20 and migration of centrosomes occurs early in the cell cycle = in=20 male GSCs, as centrosomes were already separated in 40% of = the=20 male GSCs observed (Yamashita=20 et al., 2003).

Adenomatous polyposis coli 2 (APC2) protein that is localized = to=20 the cell cortex where the GSC contacts the niche may link the = adherens junctions and astral microtubules emanating from the = nearby=20 centrosome, as loss of function mutations in apc2 = result in=20 the misorientation of centrosomes during interphase and = spindles=20 during mitosis (Yamashita=20 et al., 2003). This linkage to APC2 and the adherens = junction may=20 also help stabilize the astral microtubule array. The=20 centrosome=96cortex interaction also appears to be important = in=20 neuroblasts because mutant neuroblasts lacking astral = microtubules=20 (such as in cnn or asl mutant) cannot correctly orient their = mitotic=20 spindles (Megraw=20 et al., 2001; Rusan=20 and Peifer, 2007). Also, proteins required for = microtubule=96cortex=20 interaction are essential for neuroblast spindle orientation; = the NUMA (nuclear mitotic apparatus protein)=96related Mud=20 protein, which interacts with centrosomes as well as the cell = cortex via Pins, and the dynein complex play an essential = role=20 in neuroblast spindle orientation (Siller=20 et al., 2005, 2006;=20 Izumi=20 et al., 2006). Although the mechanism that marks special = cortical=20 domains might be different in GSCs and neuroblasts (APC2 vs. = Pins),=20 anchoring of centrosomes/spindles to the cortex might be a = conserved=20 mechanism to orient the mitotic spindle.

<= !-- null -->Still in Eden: male GSCs in the niche maintain = a=20 centrosomal Eve
Strikingly, differential labeling of = mother=20 versus daughter centrosomes in male GSCs revealed that it is = the=20 mother centrosome that normally maintains position next to = the niche=20 and the daughter centrosome that migrates to the opposite = side of the=20 nucleus (Yamashita=20 et al., 2007). The asymmetric behavior of mother and = daughter=20 centrosomes ensures the stereotyped positioning of = centrosomes within=20 the GSC, which, in turn, sets up the perpendicular = orientation of the=20 spindle once the GSC enters mitosis. In turn, the oriented = spindle=20 programs the normally asymmetric outcome of the stem cell = division,=20 retaining one daughter cell attached to the niche and its=20 self-renewal signals, whereas the other is displaced away = from the=20 niche and is free to differentiate. As a result, it is the = mother=20 centrosome containing the oldest centriole that is = consistently=20 inherited by the stem cell. Thus, male GSCs maintain a = "centrosomal=20 Eve," a very old centrosome that contains a centriole = assembled many=20 cell generations earlier (Yamashita=20 et al., 2007). It will be interesting to examine whether = it is=20 also the mother centrosome that maintains a robust = microtubule array=20 and maintains apical position in larval neuroblasts. The = similarities=20 between male GSCs and larval neuroblasts raise the = possibility that a=20 novel, developmentally programmed centrosome cycle with = differential=20 regulation of two centrosomes within a single cell may be a = general=20 mechanism in stem cells or tissue progenitors by which a = stereotyped=20 spindle orientation is set up before spindle assembly. =

Why the centrosome? Hints from other=20 systems
Studies on centrosome behavior in other = systems may=20 shed light on how the asymmetric behavior of centrosomes in=20 asymmetric stem cell divisions may be programmed. = Observations in=20 mammalian cultured cells suggest that structural differences = between=20 older and younger centrioles can be used to confer = differential=20 behavior on mother and daughter centrosomes. Mature and young = centrioles have different structural features, including = subdistal=20 appendages that appear to allow mature centrioles to better = anchor=20 and maintain microtubules nucleated from centrosomes (for=20 reviews see Urbani=20 and Stearns, 1999; Delattre=20 and Gonczy, 2004). Perhaps as a result, mother and = daughter=20 centrioles have been observed to behave differently during = early=20 interphase in mammalian cultured cells. Mother centrioles had = a more=20 robust microtubule array and remained relatively stationary = during=20 interphase, whereas daughter centrioles had fewer = microtubules and=20 tended to move actively around the cell (Piel=20 et al., 2000, 2001).=20

It takes 1.5 to two cell cycles for centrioles to mature (for=20 review see Delattre=20 and Gonczy, 2004). Although the reason why it takes this = long for=20 centrioles to mature is not fully understood, this extended=20 maturation time might be exploited to confer different = properties on=20 centrosomes in the same cell. The mother centrosome contains = the=20 oldest centriole (the grandmother centriole) and a newly born = centriole, whereas the daughter centrosome contains a = centriole=20 assembled during the previous cell cycle and a newly born = centriole.=20 Thus, the mother centrosome may have a higher capacity to = maintain=20 microtubules as a result of the more mature structural state = of its=20 oldest centriole. If the gradual maturation of microtubule = anchoring=20 capacity is also true for Drosophila centrioles, the = unusually=20 early separation of duplicated centrosomes in = Drosophila male=20 GSCs may help the daughter centrosome move away before it = matures=20 enough to anchor many microtubules and be trapped near the = niche-GSC=20 interface. Although there are as yet no known structural = differences=20 between Drosophila mother and daughter centrioles, = such as the=20 distal appendage observed in mammalian centrioles, the = daughter=20 centriole is shorter than the mother centriole for most of = the cell=20 cycle in Drosophila cells, which may confer = qualitative=20 differences between mother and daughter centrioles (Vidwans=20 et al., 2003).

Presumably as a result of the asymmetric centrosome behavior = in=20 Drosophila male GSCs, the mother centrosome is normally = segregated=20 into the cell that maintains stem cell identity (Yamashita=20 et al., 2007). It is tempting to speculate that one or = the other=20 centrosome may harbor fate determinants, which are then=20 differentially inherited either by the stem cell or the = daughter cell=20 that initiates differentiation. Indeed, asymmetric = inheritance=20 of a fate-determining mRNA that associates with only one=20 centrosome during early embryonic development has been = reported in a=20 mollusk (Lambert=20 and Nagy, 2002). It remains to be established whether=20 asymmetrically inherited centrosomes in stem cells are = carriers=20 of developmental information or innocent bystanders that are=20 differentially segregated because of their role in spindle=20 orientation during the preceding mitosis.

Centrosomes as integrators of cell cycle=20 events
In budding yeast, differences between the = mother and=20 daughter spindle pole bodies (SPBs), the functional = equivalent of=20 centrosomes, appear to be used in establishing the = stereotyped=20 orientation of the mitotic spindle and, thus, successful cell = division. Because bud production and growth occur before = nuclear=20 division, spindle orientation must be correlated with the = nascent=20 bud such that one nucleus is reliably sent off into the bud. = In=20 unperturbed budding yeast cells, the mother SPB, which has a=20 more robust astral microtubule array as in Drosophila male=20 GSCs, is normally directed toward the bud (Fig.=20 1 E). These astral microtubules are captured and = stabilized by=20 the bud tip cortex in a Kar9-dependent manner, guiding the = mother SPB=20 to the bud tip (Liakopoulos=20 et al., 2003; Maekawa=20 et al., 2003). Kar9 may be an orthologue of APC in higher = organisms, raising a potential conserved link between the = centrosome=20 (SPB)-astral microtubule-APC2 (Kar9) cell cortex (Bienz,=20 2001). The fact that the mother centrosome is inherited = by the=20 stem cell in male GSCs but that the mother SPB is normally = inherited=20 by the bud in Saccharomyces cerevisiae raises the = question of=20 whether the bud might be considered the primitive stem cell=20 equivalent in yeast. Indeed the mother yeast cell can only = divide up=20 to 3D~50 = times, thus=20 displaying some attributes of a transit-amplifying cell, = whereas the=20 division number=96counting system seems to be reset in the = bud, which=20 can keep dividing.

In addition to possible fate determinants, centrosomes may = harbor=20 mechanisms that sense the state of the cell and regulate cell = cycle progression. Components of the mitotic exit network = such=20 as Tem1, Bub2, and Bfa1 are asymmetrically localized to the=20 mother but not the daughter SPB (Fig.=20 1 E; Pereira=20 et al., 2000, 2001,=20 2002;=20 for review see Pereira=20 and Schiebel, 2001). Interaction between the GTPase Tem1 = and=20 Lte1, the guanine nucleotide exchange factor for Tem1, which=20 localizes specifically to the bud cortex, appears to be a = part of the=20 spindle position/orientation checkpoint. When the mother SPB = enters=20 the bud, localized Lte1 activates Tem1, which activates the = mitotic=20 exit network, allowing cell cycle progression (Pereira=20 et al., 2000, 2001, 2002; Pereira=20 and Schiebel, 2005). One wonders whether adult stem cells = in=20 multicellular organisms might use a similar orientation = checkpoint=20 mechanism to ensure the asymmetric outcome of stem cell = division in=20 the context of the niche microenvironment. In budding yeast,=20 inheritance of the mother SPB to the bud appears to depend on = the=20 ability of the mother SPB to harbor more astral microtubules=20 because transient destabilization of astral microtubules by=20 nocodazole resulted in the randomization of mother-daughter = SPB=20 inheritance. Thus, it may be that it is the asymmetric = loading of=20 checkpoint components rather than intrinsic, asymmetric = differences=20 between mother and daughter SPBs that is important for = spindle=20 orientation and its coordination with cell cycle progression. = There=20 are striking parallels between Drosophila male GSCs = and=20 budding yeast: (1) the centrosome (SPB)-astral = microtubule-APC2=20 (Kar9) cell cortex link, (2) spindle orientation with respect = to=20 tissue/cell polarity (niche or preformed bud), and (3) the=20 mother-daughter centrosome (SPB).

Concluding remarks
The = developmental=20 programs that establish male GSC fate or larval neuroblast = identity=20 are able to reprogram the behavior of a fundamental = cytoskeletal=20 organelle, the centrosome. In the resulting novel centrosomal = cycle,=20 one of the two centrosomes retains a robust microtubule array = and can=20 be anchored through it to a specific pericortical site. In = contrast,=20 the other centrosome loses MTOC activity and is free to = migrate. The=20 asymmetric behavior of the two centrosomes, which is perhaps = based on=20 different capacities of mature versus newly assembled = centrioles,=20 can then be used to set up a stereotyped orientation of the=20 spindle with respect to either an external niche or localized = intrinsic determinants, providing for a reliably asymmetric = outcome=20 of the stem cell division. Thus, the stem cell program is = able=20 to impose an extra layer of regulation to modify general cell = division machinery such as the mitotic spindle and the = centrosome=20 to orchestrate cell division within the context of tissue=20 architecture.


3D""    Acknowledgments=20
 
We apologize to colleagues = whose=20 works were not mentioned because of space limitation. We = thank Drs.=20 Cheng-Yu Lee and Hiromi Maekawa for comments on the = manuscript.=20

Y.M. Yamashita was supported by a Jose Carreras International=20 Leukemia Foundation fellowship, and M.T. Fuller is supported = by=20 the National Institutes of Health (grant P01 DK53074).

Submitted: 11 July 2007

Accepted: 30 November 2007


3D""    References =
Top
Abstract
3D"References
&nb= sp;

Bienz, M. 2001. Spindles cotton on to junctions, APC and EB1. Nat. = Cell=20 Biol. 3:E67=96E68.[CrossRef][Medline]

Cabernard, C., and C.Q. Doe. 2007. Stem cell self-renewal: = centrosomes on the=20 move. Curr. Biol. 17:R465=96R467.[CrossRef][Medline]

Chen, D., and D. McKearin. 2003a. Dpp signaling silences bam = transcription=20 directly to establish asymmetric divisions of germline stem cells. = Curr.=20 Biol. 13:1786=961791.[CrossRef][Medline]

Chen, D., and D.M. McKearin. 2003b. A discrete transcriptional = silencer in=20 the bam gene determines asymmetric division of the Drosophila = germline=20 stem cell. Development.=20 130:1159=961170.[Abstract/Free Full Text]

Delattre, M., and P. Gonczy. 2004. The arithmetic of centrosome = biogenesis.=20 J. Cell Sci. 117:1619=961630.[Abstract/Free Full Text]

Deng, W., and H. Lin. 1997. Spectrosomes and fusomes anchor mitotic = spindles=20 during asymmetric germ cell divisions and facilitate the formation of a=20 polarized microtubule array for oocyte specification in = Drosophila.=20 Dev. Biol. 189:79=9694.[CrossRef][Medline]

Estivill-Torrus, G., H. Pearson, V. van Heyningen, D.J. Price, and P. = Rashbass. 2002. Pax6 is required to regulate the cell cycle and the rate = of=20 progression from symmetrical to asymmetrical division in mammalian = cortical=20 progenitors. Development.=20 129:455=96466.[Medline]

Fuchs, E., T. Tumbar, and G. Guasch. 2004. Socializing with the = neighbors:=20 stem cells and their niche. Cell. 116:769=96778.[CrossRef][Medline]

Gonzalez, C. 2007. Spindle orientation, asymmetric division and = tumour=20 suppression in Drosophila stem cells. Nat. Rev. Genet. = 8:462=96472.[CrossRef][Medline]

Izumi, Y., N. Ohta, K. Hisata, T. Raabe, and F. Matsuzaki. 2006.=20 Drosophila Pins-binding protein Mud regulates spindle-polarity = coupling=20 and centrosome organization. Nat. Cell Biol. 8:586=96593.[CrossRef][Medline]

Kaltschmidt, J.A., C.M. Davidson, N.H. Brown, and A.H. Brand. 2000. = Rotation=20 and asymmetry of the mitotic spindle direct asymmetric cell division in = the=20 developing central nervous system. Nat. Cell Biol. 2:7=9612.[CrossRef][Medline]

Kiger, A.A., D.L. Jones, C. Schulz, M.B. Rogers, and M.T. Fuller. = 2001. Stem=20 cell self-renewal specified by JAK-STAT activation in response to a = support cell=20 cue. Science. 294:2542=962545.[Abstract/Free Full Text]

Kuang, S., K. Kuroda, F. Le Grand, and M.A. Rudnicki. 2007. = Asymmetric=20 self-renewal and commitment of satellite stem cells in muscle. = Cell.=20 129:999=961010.[CrossRef][Medline]

Lambert, J.D., and L.M. Nagy. 2002. Asymmetric inheritance of = centrosomally=20 localized mRNAs during embryonic cleavages. Nature. = 420:682=96686.[CrossRef][Medline]

Lechler, T., and E. Fuchs. 2005. Asymmetric cell divisions promote=20 stratification and differentiation of mammalian skin. Nature.=20 437:275=96280.[CrossRef][Medline]

Liakopoulos, D., J. Kusch, S. Grava, J. Vogel, and Y. Barral. 2003.=20 Asymmetric loading of Kar9 onto spindle poles and microtubules ensures = proper=20 spindle alignment. Cell.=20 112:561=96574.[CrossRef][Medline]

Maekawa, H., T. Usui, M. Knop, and E. Schiebel. 2003. Yeast Cdk1 = translocates=20 to the plus end of cytoplasmic microtubules to regulate bud cortex = interactions.=20 EMBO J. 22:438=96449.[CrossRef][Medline]

Megraw, T.L., L.R. Kao, and T.C. Kaufman. 2001. Zygotic development = without=20 functional mitotic centrosomes. Curr. Biol. 11:116=96120.[CrossRef][Medline]

Morrison, S.J., and J. Kimble. 2006. Asymmetric and symmetric = stem-cell=20 divisions in development and cancer. Nature. 441:1068=961074.[CrossRef][Medline]

Pereira, G., and E. Schiebel. 2001. The role of the yeast spindle = pole body=20 and the mammalian centrosome in regulating late mitotic events. Curr. = Opin.=20 Cell Biol. 13:762=96769.[CrossRef][Medline]

Pereira, G., and E. Schiebel. 2005. Kin4 kinase delays mitotic exit = in=20 response to spindle alignment defects. Mol. Cell. = 19:209=96221.[CrossRef][Medline]

Pereira, G., T. Hofken, J. Grindlay, C. Manson, and E. Schiebel. = 2000. The=20 Bub2p spindle checkpoint links nuclear migration with mitotic exit. = Mol.=20 Cell. 6:1=9610.[CrossRef][Medline]

Pereira, G., T.U. Tanaka, K. Nasmyth, and E. Schiebel. 2001. Modes of = spindle=20 pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint = protein=20 complex. EMBO J. 20:6359=966370.[CrossRef][Medline]

Pereira, G., C. Manson, J. Grindlay, and E. Schiebel. 2002. = Regulation of the=20 Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase = Cdc14p.=20 J. Cell Biol. 157:367=96379.[Abstract/Free Full Text]

Piel, M., P. Meyer, A. Khodjakov, C.L. Rieder, and M. Bornens. 2000. = The=20 respective contributions of the mother and daughter centrioles to = centrosome=20 activity and behavior in vertebrate cells. J. Cell Biol. = 149:317=96330.[Abstract/Free Full Text]

Piel, M., J. Nordberg, U. Euteneuer, and M. Bornens. 2001.=20 Centrosome-dependent exit of cytokinesis in animal cells. = Science.=20 291:1550=961553.[Abstract/Free Full Text]

Rebollo, E., P. Sampaio, J. Januschke, S. Llamazares, H. Varmark, and = C.=20 Gonzalez. 2007. Functionally unequal centrosomes drive spindle = orientation in=20 asymmetrically dividing Drosophila neural stem cells. Dev. = Cell.=20 12:467=96474.[CrossRef][Medline]

Rusan, N.M., and M. Peifer. 2007. A role for a novel centrosome cycle = in=20 asymmetric cell division. J. Cell Biol. 177:13=9620.[Abstract/Free Full Text]

Siegrist, S.E., and C.Q. Doe. 2006. Extrinsic cues orient the cell = division=20 axis in Drosophila embryonic neuroblasts. Development.=20 133:529=96536.[Abstract/Free Full Text]

Siller, K.H., M. Serr, R. Steward, T.S. Hays, and C.Q. Doe. 2005. = Live=20 imaging of Drosophila brain neuroblasts reveals a role for = Lis1/dynactin=20 in spindle assembly and mitotic checkpoint control. Mol. Biol. = Cell.=20 16:5127=965140.[Abstract/Free Full Text]

Siller, K.H., C. Cabernard, and C.Q. Doe. 2006. The NuMA-related Mud = protein=20 binds Pins and regulates spindle orientation in Drosophila = neuroblasts.=20 Nat. Cell Biol. 8:594=96600.[CrossRef][Medline]

Spradling, A., D. Drummond-Barbosa, and T. Kai. 2001. Stem cells find = their=20 niche. Nature. 414:98=96104.[CrossRef][Medline]

Tulina, N., and E. Matunis. 2001. Control of stem cell self-renewal = in=20 Drosophila spermatogenesis by JAK-STAT signaling. Science. = 294:2546=962549.[Abstract/Free Full Text]

Urbani, L., and T. Stearns. 1999. The centrosome. Curr. Biol.=20 9:R315=96R317.[CrossRef][Medline]

Vidwans, S.J., M.L. Wong, and P.H. O'Farrell. 2003. Anomalous = centriole=20 configurations are detected in Drosophila wing disc cells upon = Cdk1=20 inactivation. J. Cell Sci. 116:137=96143.[Abstract/Free Full Text]

Yamashita, Y.M., D.L. Jones, and M.T. Fuller. 2003. Orientation of = asymmetric=20 stem cell division by the APC tumor suppressor and centrosome. = Science.=20 301:1547=961550.[Abstract/Free Full Text]

Yamashita, Y.M., A.P. Mahowald, J.R. Perlin, and M.T. Fuller. 2007.=20 Asymmetric inheritance of mother versus daughter centrosome in stem cell = division. Science. 315:518=96521.[Abstract/Free Full Text]

Yu, F., C.T. Kuo, and Y.N. Jan. 2006. Drosophila neuroblast = asymmetric=20 cell division: recent advances and implications for stem cell biology.=20 Neuron. 51:13=9620.[CrossRef][Medline]


=20 CiteULike   =20 Complore   =20 Connotea   =20 Del.icio.us    Digg    Reddit   =20 Technorati    What's this? =

Related Article

Cell biology of stem cells: an enigma of asymmetry and=20 self-renewal=20
Haifan Lin
J. Cell Biol. 2008 180: 257-260. [Abstract]= [Full Text] =



This article has been cited by other=20 articles:=20

  • Lin, H. (2008). Cell biology of stem cells: an enigma of asymmetry = and=20 self-renewal. J. Cell Biol. 180: 257-260 [Abstract]= [Full Text] =  

This = Article
3D"
3D"Right Abstract=20 3D"Freely
3D"Right PDF=20 (Full Text)
3D"Right Alert=20 me when this article is cited
3D"
Services
3D"
3D"Right Email=20 this article
3D"Right Similar=20 articles in this journal
3D"Right Similar=20 articles in PubMed
3D"Right Alert me to new = content in=20 the JCB
3D"Right Download to=20 citation manager
3D"
Citing = Articles
3D"
3D"Right Citing=20 Articles via HighWire
3D"Right Citing Articles via CrossRef =
3D"
Google = Scholar
3D"
3D"Right Articles by Yamashita, Y. M. =
3D"Right Articles by Fuller, M. T. =
3D"
PubMed
3D"
3D"Right PubMed=20 Citation
3D"Right Articles by Yamashita, Y. M. =
3D"Right Articles by Fuller, M. T. =
3D"
Related = Collections
3D"
3D"Right Related=20 Article
3D"
Social = Bookmarking
3D"
3D"                     
What's = this?=20 =

  Home | Help | Feedback |=20 Subscriptions | = Archive | Search | Table of Contents=20

------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/banner/title.gif R0lGODlh3AAsAPcAAP////y0pvlzWf/7+v7u6/YyDP7f2f3f2f3VzfhfQfY5FPmAafy3qfusnfZA HPZFIvuhj/hjRv7j3fumlfdUNPzAtPyzpPuikPddPvl0Wvudi/739vqXg/7s6fqIcv3Tyv3RyPZC H/3Mw/y5q/hlSPdZOvqVgfdOLfYxC/mFb/UxCvdfQPdYOfdRMPUwCfQpAPY/G/Y1D/U0DfunlvU0 DvY+GvY7F/Y8GPY6Ff7x7/UzDPY2EPufjfY9GfdNK/UzDfy9sfY+Gf7o5PY3EvZHJfY9GP/39fdW NvY/GvY8F/Y4E//+/vY0DvY1EPzIvfY7Fvl4X/urm/hxVvqIcfY4EvY3Ef3Wz/7k3/Y2EfhpTf3a 0/ZDIPZGI/ukk/Y5E/3Qx/ZBHv/9/P3Xz/dLKf7q5vl/Z/7m4fZHJPqSfv/8+/3h2/hkR/uun//6 +fqTf/ZKKPl3XfupmfzHvf3LwfUyDPhuU/7t6vzBtvzEufl3XvdMKvdXN/Y/HPzFuv/9/fzCtv73 9furnPqQfPqfjfy1p/qPevqZhfUzDvl2Xf7v7Puwovuxo/y+sf/29P/29funl/3c1f/18/ullPl9 Zf/8/Puqmv7q5/hsUfdNLPdPLvzIvvdTMvzDt/l2XP3NxPl+Zv3c1v7n4vZIJvdJJ/l5X/qbifmC av7p5PhqT/3d1/qKc/3IvvmHcf/z8PZJJvdXOP7o4/qQe/7w7v3X0P/x7vdaO//x7/utnvhZOvY6 FvhhQ/mIcfl5YPy7r//59/7d1/7e1//5+PhrUPuyo/hvVPdEIPU1D/3Y0P7l3/h1XP7w7fdMK/7y 7/3SyfdQL/uqm/dbPPhoS/y/s/uwofzDufqVgvujkvqNd/UyC/U0D/y9sP7k3v3g2vuah/qLdf7g 2v708fzJvv///vzJv/dKKPZIJfy5rfy6rfhnSvhmSf7n4/uZhvUsBPl4XvU9GP7z8PU2EP/y8P/z 8fzCt/Y0D/3Oxvy2qvzGvPzHvPmEbP3d1vY6FP7m4vdHJPYyC/dJJiH5BAAAAAAALAAAAADcACwA AAj/AAEIHEiwoMGDCBMqXMiwocOHECNKnEixosE2eMwB2QgkgJmFfuxwm8PGTRliWVKmFFAGTYM5 anIoFEKIo82bN7UBwfMFEjJaFoMKHUpUqKxiKGIojfGiW0JmEBI8YfJjh4IbNWBo1VrjBo4dP35s +fQN4YUXS9OqXRuDxg8ZMcBculO0rt27dXP4sLEVhg4eCOdtoqMka9/DiGEUKXDGycEZMhJLltwj RhU0S/Bq3sxZoV6+W/8etKBAyeTTW6k8AGYQMurXWnuokNS5tm3Nn/uKLoggyBPYqH/AaR0ZOOon /cjcXs7cYu7QgAmGQdcEcQ0lMcLKoOFWx48YChAH/ylyrKDrvjV2NFnPvv2OKqAP0+nSvL79hs+1 7h6IpwqSw1TYEEE+1UAwQyBxdDGICQuUsEMPh+lwgXnFxcZFJ1BkqKGGpHSCCiZYGLZVDFDcZ+KJ BOXnV3QDLUDDYVVE4ElmCTlijQ0iwrBDBhT2hcMeNCrUgQnh9aUABmGgqKR9Ku4HQCMU4ODjEYk4 1M4ORmIwAEHnaYXDEUY4VMcQfSUxBiBLprlckywCgACOfTHBxkMMxNDXE5m8w2WFMHwZZkOD/NBX EQ+0ouahnbFJ0Dl2btWDA6w55IkS/2lVBBcfDdRln2A6ZEGjlj4QD6Kk4qXoQHHwiQMFjjz0hQJB IP8haxFgGLDnlH8yZE91WxEqT6nAFnWqQKUIupUSJATJUD0FYDHEs008EalAm/rpUAMvbmWDHhsE 621QwwIQS7ZaVVEHRDncI4cT7MoRTiO3bmVtQxwYq5USCfjx7b4ThasKuTpKYVe1nTaUBRV9HbIA vwyju5dubU4B8A4C11XtKw1RwgMVlcJQgzF0NSzyQuFK3BfFA/N5gx4TROHyyy8HIsk1usC6VQ0u wKHsyDyn+DB0BJm8FcoW8wlDENlwp/TSbtFQGFc7HIKILT1XXVDJE1dc1KbGbRXEA1D0YfXYA2F9 stZEcd01DD2MUgYQypA9ttlDoz2U2jUEoffefAf/kWMPOzCxzCJyV023VkRvbTTbPTTu+OM94KAU hFspQIMFhfN8eMAp39nCF2JYIfroooshxheEmNJVX/uQE0nmKF4h++xXtJHQ5omnrSqQDjGQRI7Y HAD7iQ8UX/wWZ6Ry+8/6tfnv2REtIf30S4gTr5cFNxQNmSMSMryJRYQffi5IQLJ8fCsSVAjA5kIU xiQJRCB/BCU8cj2nuTLkhr0wKIDG9/c5TA/AAIrzQYwghuDfENIBkTTgwh9KiKAS2FGI+82rIXHg 3w3KAED7CJCABgzNhAbSBf7hgAW+eEgaElAkrfzADRbMHkMUAaqjJaOD9REgH7SQkEToIQl9+cEM /wiiCHoM6gGZaogRjiClrfzgf5pSlQwX8gyABeGGOGROjsYzi4QI4Qw36EsMCDeQP2DhMDvgxEMs wYUiBLEaMczfQgTBvyLwIovMAQMaK5AQBDwhR1UQ20D0cbS+YCEPdKrCYX5Anyji6iEr8MKddoHH 5WwCiFvBggASkg9exaZWBGkDNFrosSFoQF8L+YUzmpjJkFFrdw4JgyEQ1hclaKCStxEAlowEB3yo gQwEsIMZQJACHORoVXJMAf+ONoQ1PKIZajiFHRJBgA7A4gBzEMQ/FOCAvtzgAfy4XxIy8QdNsOuc 59REH0awjgg8rS80oAYubQMBOiBmB17YgijG8P8GLiQBHjmCQQwQWZBxUCGgMKACE56whXK8YQz8 JEIIFMAETPZlCMm6n8eo8KyOepSjO5CBaRDzAwnMszZWsEEQrFOEJLgUK4mJgRoLsgRh1BA9RbiB S1/aA4RqBQUN6BFiZEXUonYsMTg4AZpO2plJoIAPa+MDE0iwJYNoYaJrS8wP1iBHtWWVKyqoBFNr QwYWFMCnk2HCKHiIEGmAgQlofc0NUFCLbRDnq4jBgQo8sLOx4iUUAqgCDa7i0xoUQXJMWANbEyKG SyhhsL+bTA16cIMneCEGTNiCNwhwkAmo4AagDa1oRyvaJNgAB0pgAhNOIFa/3mYVnyjBGZ6ABaWH 0IAJMcDnFiiACEbYriGeYAUGXPGEwIXlB7h1Vni44IwV5OEWV0hIFNxBhOpa97rYva4oMHGECCxg BJx1LXOCIYQP3IEQ04hCA4bRCxFIQI4OSQMZmgEENkygCxNoACEYIYcvaCEU4KAEQyKhDiEY+MAI TjCCLZED+Ir3wRCOsIQnTOEKFyUgADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/adsystem/graphics/1201712515114/jcb/FZ_220x40.gif?ad=16852&adview=true R0lGODlh3AAoAMQTAPn5+Q9vpiYyUJCfuMfO2mZ7odAhIOjp6+umoae0xbzDz9Xa4+/Cv+Di5+h+ d/Ly8vfc2v///zpOgf///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH/C05F VFNDQVBFMi4wAwEAAAAh+QQFyAATACwAAAAA3AAoAAAF/6AkjmRpnmiqrmzrvnAsz3Rt33iu73zv /8CgcEgsGo/IpHLJbDqf0Kh0Sq1ar9isdsvter/gsHhMLpvP6OegsBqskQPCIJ0u2E12tkQRaawi EXMseXc0CQARBHQShIV4BW56jI2SRwOAlQURAIIJEQt/gYOABwSAoDIHkAmLpokHEQ+CIgMNfQMJ DxFsl30EAAALlUS9mYCzwyfHo6IFiAoxcYsjriJ8uyKeD5V+EsWMutCWmCSaoi/LK+aC1TC/0yLt 697pJt8S7Ub3IvPebiO4CAgkwOpYgQRyUPRrN0ABQT2Q1hQgAAmQgjfeHCaQFNGOoojeEmbcOAKS gosl//81JEmiIUGMBx+ikLeMVIp7pg7AMZinF7tE2YDCEgSIQANYEVjhSRdOwgJRD1Qx2tRragQF ep7O4aNUEydA9HydSvA0gtQCDRLkAhp2gSupjIDxihAUmqlZJBhusgNI6YlvXvESA0S48DlTHxHN fSDCJr5YJ8wlGPAU1CXGe65aXbBAp4R0fFCZY2OOs06fYef0A0gOdT9YflW3hmzC1cFlqFH0UvtA WJJ9Vn9+nI05XdWliSKJsKWIHuPVn8/V6xucNV2reurRmn09+hzgEjxd95rMlZtZuf8W3SRuJ7aS 6RCL0Bpe+rnjJaBHfzBQIHYSy6xW1H/bjUeOd/wk0MD/NXN1h5tiJbjSH0W1gVXCbjdhglQyQwC3 EFu3EXDALMZZmJ92EujSXDkHNtbMdJqNZh0/B+LWx3/42fjeCNewkA+AZmW4S2m/tVjdY80VMKIJ JXbH4jk8mgjfjgimmBQ/iMi243EyIqiLlg2OECAifhXIYV5SjiCeYNaxcQ2bQngYH1sKBHNedvel SSOUe4pzR5cuCnKJZ5eI1iKXNYoCCzTihRloUNvQIgIsvnlzwo8krFkSVmGRpgtcRch5GFu9FFbQ OeJFhiIjSJlFmpH1DMCfJ34Biig2zogyACKyPKUKl1mqWZggE20CDJyYtnSNiA8odU8vK15RwAIS mYKZSw55zOAItiXBsC0/32p7Jhia4KUnPOhKsWslmqXr7hSarKhApO/WC8VEpShQpr389uvvvwAH LPDABBds8MEIJ6zwwgw37PDDEBscAgAh+QQFlgATACwUAAAAxwAoAAAF/6AkjmRpnmiqrmzrvrBU DENi30qi7PxOKL8gECgMFofHQWzJbDqf0NMCcnhUH9isNgvoer/gsPiriJrP6LRLIJAc3vCtnDuu ix/gsnrP7zPZEm1WcAcOBHNbdop2en6Oj5AkgA1xCAYOiHSLm3mRnp9obWwCBVRwDg4GCgBXiZyv Xo2gs7Qwo6SUVQMGC6isVq6wr7K1xcYmoqQQuZcJlgqIwrDEx9XFtwVvBKkIBwqXDHLSsATW5teB bKUHDQwNCwdUDQ3i45zl5/mfyaRxBwAQMtl7hU+fwUe3BsQBYAkTAGADhRU8uGeGEnNt0glQ+IZB KgMgu+GJSK4ajQEFIP8NiBBBX0JTH0FegkBSorEBDxYMIBDhop+VLc/xSxCHgUwENaVNBJWtEcpH QF2OIsrlgQMGEZIKW1BsZQJQUYVqhNYKQFatW7tGeJCyBI0CBXL4lLFTwdwZP+7uKJCAZT5+Cq6g Hci1VgGWEQi0FZHVLk4AXyWsbCChb+TJlSNcZqmjgd+/ow5hGWyvcK2+iBuxxIc6JR4lBcy6BgBb toQHmkUs+GyNn4AFmkjDMl0LJ2J8LC8epn04QtvkQJ/3jC4iLEaNwEcKT2vSrHMJyUU0p8FyAYHz BGiYNY9e/XfJvDFO0j7QqkPC5panDC8DOsvF1f3nloDwBXXdKP+Q1ID/TA7QBEZWENpBWTEAfsZZ gM7FlhsJzUU2wngioCbWKLdFVIhMDNKHGGJ1HEDhAm2tdBFLAIhwQGIiKLBWjDnuWJ2NOBawm4Hy CWLPAUahqCQCDq5I4xguGtbFIQf4xNmNEcA4Amr8ZYaYcp4dkF58x/AjgRf0KQKBJUq2GRKWK7Z4 DFwmhEenCXeWkCeHFGl020hx2oFkTG6GhIeTET4YpT5d9hnFLaQA6uQXktL4wDeFPubdpE9+sWg+ jTpqhjqjbRqoqSzu2CZSiEIY4VleTMhoT6KOik1AlcbZKotWySQBA11wmugdB503V61PjILTaDTq ahaqce5iAFaIevfsuh2sIKvtH7dQdai1zT7bbLhZXQWtuGPggcWn27bbwlRvAIruWeOC+2xArtqL rRbsuusvMt1WUUWwYuT7KsGmohsGIv2KkNG//o4SWJp2DPtFqgqj+RDDyEAcsUYCQJMUvdeCoW4m D8hawsMeI8vPAmPAipYcrbSSAssti3oLPQQfnNQcAg8i9Ak45+woP/R8K/PC6m5y8hZBx2sz0UZr K4oEOyyg9dYEcI3e1+eZxx57YJeNHhJEDKFCCAAh+QQFlgATACwyAAAAqgAoAAAF/+AkjmRpnmiq rmzrvqYyyfRsw6SM73zv/7jD5EEcDh9HonKJbJ4ABaB0Sq2aDo2GCNBjJolQq3hMXh0OC8UBwB5F Ijj46YEmKBKJwaDAL/v/PGcQeG1uBAlxE3KKWwBvj5BagJOUKg0EAwxcRhENAgJIL4uMcGymp2yS lauURAeDA2sAoQ8CEgINoypvInJyqMCqrMN/aAMIE4UTEgW1DC6LusnAp0LE12UHDAMLm3AFAg4D AgkRoShw0Yy91NXY71YLDXnTM+ADg7bn0LrtEanwAkp5NUBBmwcQFDBQM8BBAUT7dj1pB1CgxR6Y IKhYAoRixRN7ThTQEyXFyJATRv+ekMDyIo5BiEwwECCDY4t0JjwCaMCnJx8JySKUJFHA0VCRRlM6 GmCCJVCXL7Y96xVBwa1Pz5SImkgxF6Q3zP49JfrmqIkCZUU8EDpCpVOoLh5gWsvo6qdPC4qsGMWL hE6vBJb1SdmyBFq2JtOmHFou8Fu4LB7goerp7l2z0HJ6BLyscGLEKA5jnkAggmPPkHOag4Dv0RAE 4wSAKwAhIgtdpTa/Oc3yZNsEmESPGBB4wFPRzCaEjBXhwB6SbZmmHvFAgXScIhDQFvN3d2eWA/o2 g5PgQNqiUNA2AIo2pfswBRbYkyDf2gTg06kXTIfTNpXuXxEgAVNyEADAAUCVQ1j/aVZNYJ5xwq2z TGlMDahISQ9Il98C+JCyjn8nSKMCgDz1ZOEyjCTA3jcSwGEcaTMk15YIBbC0QAQVSrAWIrHkJ8IB CCiInVok8IUTXysAGFgJcADl4oqLwXHAkveFRRhyTuZYDhzW+eggcSucYwokpGDni2Zs/IMKZySE h+KTKX3T3otEkSVUSzh2dlgCm/jYZV8jjsmfa/8caYKaaQbjHYrKNZkiUG7WuNYCYxkW551ZfqfA GzHlJ5kOSY6Z6FeHIjmNI9SYZ9p3jaKICABAbeqemy/20V6NwklgnopOoRWGj9uYFygwapLKJKAj iKroqk4NCKh8Ow3gyHDnCHgp/64XLiMti0BNOd0m1WnIlahvCOrasYDmhuiaTVUqQm+dnZUCajSa gEl+s7BGZanlOvJVmmQyqQgvv2zmwmNkFGAfXA/MIleHyeIGib+FGpvCKH8dTK8V96bWxCAytPGL wOWW7C8P1DTcsDAqICwGWqNdRASHtSl7caEAi8hFn2iaovJHK7hsBT2eHmBdw4kGlZMbpoTYxixP DOGzwyqz7OU7DzSQySxPm5mMIqgG1Y8cXszBBNcrXx0QHdrEwvXXpcQd1M5KuzH3EUb4twTaSlit NitCOJeAXh5ugXGRX5vthOJMVP03PG1rZDfBc6vzT2RGoLC3yn0/fs0Z8wyOjkyES0fGswmN7+23 53+ogUYCkideRcMtpO7w6qyXQQAW1kFA9+mVpN557pXIQ0CQtKcA/BgH0JE67sSLgUgCIxFA5ZLy rWKH9dxzr0AIACH5BAWWABMALDIAAgCqACYAAAX/4CSOZGmeaKqubOu+sPrEdG3feK6TzzwBk55v Rywaj7hDwxcRAUU9pHRKNT4WikezKdoCn9FhdUwuBx+QxCHinbDdKWHUTK/jeo3EYttlM7RcKDN4 doWGKz1pe05dBwYGEC5NDYeVloN5BCN8Do8OWnCBJqKWpXZoCQqbTRAGnwYIb3ykbKSmt2MPeaoj EBCdDgidoLahLhISJ8gsEgUTAyLLIgUDA864ZAdpvCMIjwgH3g5wJ3wlyOjLBesmzgkTlCkS0E3p 0wAR19hVB6kktREaQGAA7B+5chEOpEP3TISmEQMiSHi3QMU8cgwnFGCjb5+UAwqykBgICAoEBE/M /4kCmDCjtDX5RgAYgKxAMnn0ot3U6KajxyMhxXR6xKComzej+shyo1AaiYgRHg4AYg/nQRLOYv48 0oCBSCaPwoYlxyUCvllLde7UCdPmTGTVoEWDRkDuxXrNEmjKajPjBKdbX/TwOqfLULEOZh1lqVhE 07V/m7FZMKABOk2amv3QGPBvzmZaFKjB6BRwYBY9sIjpwiBsMLKLGdc6+Nje5VrXJGD+SyCCKglr aH4mAOCAiHcxq5o+HUdXlkEGEfzpEko2wKPnFiZDtxHeTd0TMruBptv33b/Hp/VUG5m5CzQKDjxx kvJsE/vWr88e4Zd9EwLfYaZZQiMQkMB5EKmnFf9Dy7lXAh4ikQDAF4Hgg50s1m1CwmPZJfNfgOEN KBd/OSXI04JVOahCAxFKKNMPFGrIWB/ymMbQh9HsJoEWFZFw3k3vNKRVZA2qCAWLq3WBzxeMjDIb S1fxZ+MybACYY3iejYeeTZ+984QqQ6ZoJA8HELAGdbA1+eI/+qW1YX9EFmBhOrt5xkRmn0mwBwDx aLRTkUaWeaaS9yF1wnyrlIUmDpD5qJ4KuUEGqHsPlPnAhBY2aSGia46JwqTMVWrmhDD+YJapmHoa A6gezQCAqMalSuETX5Cqagtwqggrprxu5muqSRUzJqv7DCIojEz+KhOnZ7nB6a237krqhKf6iiyH CmYBC62qrzYwaq2MIHrpfECYdR+Tz25LqbeRTFtqs5tRa2oJsqprZEW6ELCEu/Hu50Ky9ro3AATO Efziq4lGmQLCAZ8m0ABZQKDAEjSWgKHC9CbZcGAMsLhAFPpdaMzG6moCQTVYmGlcbM5iTPK23EyQ QCoKEFDRzQvknPMEC9hsc3g9VhECACH5BAWWABMALCUABwC3ACEAAAX/4CSOZGmeaKqubOu+cCyf wGzfeK7vPFn3wKBwCIyMDo8HAPAgOp/QKOnROIiWP6l2y5UdGspJFiqRjAqDUkGhkKBL5fI53a3f qNYrKZJHDwovcWYkgoMTDREKZxFGBQARdCKCIo6QdpctRgBfE0Z7EQ8DigQPCQlLLpMjcnEjCwAJ R39tDxGAq60itbcTb5i/JAdIniKMAAoFAgIKCbYjBIG5E3LTamdNcQW8ktLaI83QwL8Pw56MEwcD bsoIC7U2qtQrA7bShPYkBBHh4nVMTUYiAFjQgEEyARAYCKDDSJGaAWkGEPhDQhSBBAXMlEFD4OKt NBnRRVjQy0/GjRI9//aCCGjAAT5/WM7p56RJJz1tBBSA8EenTX0CI02g1yCBqE23FkCSQO7kgIEZ E2BjpK6A0gYZCwicJuHpgqhNtAIAZDURIKV5JiTgR3MHhAlJbpZgogCCAgc6R2CtZewjo1uMYtGz qaiNmLFx0pixJEEfgY1/3Sw52bXXXxH66NBzBldoWx0ATyjB8lUAAzVAL29+xmeC0nBpHkhoZiTX YsWOIdfrFEGVVs5KI9USnPYzDiYmyIk5+LQGk7RpCwAVfA7zOUYPOmpvfK6VnKWLH7uJDNT3Zd6R aE9Q4Nl4DCaoSCRQ1lXZQudiSDQo4Xho9Qn6NFELP3Eo0B0rt1kn3v9vGRnYWy4MFmMJJYGN4d4L WxUzFwQS2KcTBEtkGMw29FBHTC2F/ZfYI5RJ0gkduY1Xz1P1UBMheiQ4GMuFMGxVAzE+QFAAXvah YiFmdBRwwA+bRXTZbw5pY4ZSX5WhGH/76HYSlU5ZxtlLO1I4Fo8o/PjIDyGWACQADDzF0wAkXQHk Ifoc8ApGIjTJyIS9vMTIASG5JtBkEqoTnpZxKHUYWefRSAAvB7BF5ggCbTVofibMiYWRh6ngTUXn fKqGqCSQyo0hKAxi6qj8tWfcS3oUY+R/e5hwJqZyvbDapKUWx6Mmndxq054sWDgnDLvyiqSyoimx J7EqmKNDsrxqtQ2Ps3A98iytj4ghYg8pYWsUtjUk4ey2x64gIHLYtmtDuUl0ex2t37ZwpLv4qmDu sDddN8O9+QbcLBI+BBSQt94CLPDCJkBg0xXmCvMwFgxXHAQ5EuNKscIWd5zCAgSQJIzED3fKqcco twCBMA1UEVcTnOKX8swqtOzyvi/TrLMKCIzAhnZAdwQgyCC7JukQIQAAIfkEBZYAEwAsEAAAAMwA KAAABf+gJI5kaZ5oqq5s675wLM90bd94ru987//AoHBILBqPyKRyyWw6n9CodEqtWq/YrHbL7Xq/ 4LB4TC6TB4Ub+jtoo9Y7+FFuKthLd3xhAIikaXx+PXZtfzoEEQQngYZqfY1DBREHKQoRgiOWAyR8 dhEANpKgOwULAA0JCQcRmzmIinWfan+iSAmXkCMDl60ilwskCQ0iuTLFNbuswb03ryjHLwcAvdBA lxEJKZcKupcAhgfMU5IR3EDOP7xMfJYPKQ2XmQvqEgXf9W4SbZsDBNki+/T5G7GnVcB+/4glIMCQ oQlLmN4o8GfoIAGDA0W82qOAWj6LCfH5a7Xn0kV8zAb/TExgqKA+BSxnHGBJz0SyNPYKPIgATF/P ZBonHYAXYZgERAeGXjIK9KhQokwnSbgFq8RSFfM2WfqH9MA8bASgBkVVChvAeE6TitWHCiJJXmma SsgqYetZnogmVTshKU2fnrGUDQCW4NFcg2jzxsXlVNBNfYkZP161iRwkclUf8iTGWHHjxYLycnYc mbQgQ7fc+cLU1FJPy5CVkRPHYqGIW/dOrFK0oPInNLmbooM9XHJkWLB3+s5N0KQ2ZauzoWtKPNGI bbGDImdMAuJ11mhrXsomt2YLewcYfg0ZDFeEEfB6AxZuvV7n+rDpbxd0i9uuzMT0QQlf4lk3HVrV VeWc/36j/aHSAqLZB957s32nSHnQuTDAAXbYMc8ogS1gzlS/9MKghGkUZ5p2DQL0wAINjFjCh8VU GJ1TsFB3n4JmnVgdeQhyB5SNEoyX3Wq0qTATJ+aRcA0111R0XIsqgsYiiiKgsgI5MpKw0z/2KHPg e1gO1wc/U6KYX5ATivBlgIKhVWSGLHRCAjkDmhDhCDsBdmSVOLboo3EP7HNMMgpUhOaAu/Q0JpVo NXrXlZZV+NV3iJG5C6ObHTlnkigQkOcIXxWzS5e3pJTmY2NaGWhsOF1zDXsEJfAAAAvMU9UAD/hj 1pU6htbGArYS4OCqjN0yCa/1KQBAr57y6mtC1J1pxlQMpaBRQDss5KEHDS3tlYK3jXjLl7jX0vBA SHKm6+4TkjBTzrv0PvHAA38ogG+9/C5RgDAEdIRuvwQXbPDBCCes8MIMN+zwwxBHLPHEFFds8cUX hwAAIfkEBZYAEwAsAAAAANwAKAAABf+gQoxkaZ5oqq5s675wDIsmTdh0Pur37os6YE9IHPYSjYhy yWw6n9CodEqtWq/YrHbLhR4W3bB4TC6bz+Eves1uu99oNXxOr9vb8rs+DHgsFAkDBQGDAQl7iFh5 iYxSAH8DggGTlJMDjZheYJmcSgAEgQOVo5YAnZ2Lp4mfCaEDCQGipIdLD7a3prcRAKZNfQ+7vUy/ u7fGxsO2vFG9v8i1D8JTqap7B6CBsbGRrT0E0UuylAoAogN9BUlMsOcPBZtLsAURsKSvk+r0kwAJ 5E6AphSMOheBQKEE0qJQq2YHQANsCQgsmNjgAC5ewsqNQjhoHgB8S/hN2jUJnsgAJ0f/EThgSQnL WBqBMXkQa1c9SpcIVJpXZSHDOg8IvFpQURnGZU5kHfjSAMCgAdEoydR37iNIJewAMP0yqQAvWQs0 onQKk4koryeJEiUbQGLYnvB+3nE4MMGCA0ifiPSIsaOpSkn28ioUILC8YLzqhe1jqcEkWpTyvRwr MAAwjKXyTosr1w7hgQMULACXlFC0ZU+jVoqWlSZgfV6XOCaE9ObICK7LRhDHS2fbicBk+bPis7Ob R5+1WXqloOkwWR0tnlXyWKq8v4YoHRB4yVOhA00qbZrc9hNgAJXH0X18pbjxNrwWiHssKlAr5+FG 4fXrusGCruyoRhSAtJnyH0zSHBhb/0GWmNZgeemVFB8ltFDh3ntrYLTLF6BEwk1EI4QE1kSD1RRB SQxSwpOEB3bl3SRThcTeLgIV4Nt3j6E3CXh55UYcZxg29MtS/mVjiDBnHUVWAQKa4lss0QxCwIRd OTnJcMPkqIQ5D4jDEUyVJaREmHAFiQgvD/iHTSXd2USbJ10SQl0Am5hXIIq7HNgdJSYIw95XME1W 4jn1gPiNXQbdZiGQZh73BSDzDYTkPjLS9tKUS+jk1UtY/sekbasp4RpCJBnCWlu7yJKSVJKW2Sgc j3QYiXKzwJlAAQR50loBNob0yTkHCEKAr0LFyeuxusWpQDGiTKkVObxwFxSvhOAq1v+RP74KxzWt mEMrTghlpKETSvpy1GnJIHWUJyGxu4u76noyrpJibqatox3aFwuIo50mjWZYmDKuub7Wy0VeBmd7 Lx7YuGXRUhctPMeFEnPRQAIOOIAAAQ34O3DFblAMchYIZGyyyQgwAEHCI5chcstWQFDyyQZkXHPG CEAA8xov71yFzDYHbUDNN+vcbi61+DKMqO7qlZDALL/bbtLDNBP1Ez377AgvEEDAgMlEOzC0AQiE xEDKDJz9QNoqMxCBzEanLHPaMiNwmdtde50zAw/APbfKEdD9NgMAnG302XSj7fXbcv/Nt9s9nSz5 5JRXbvnlmGeu+eRXYKS3zUOXvcT/3AgUrnHhCJSe+mUOzB1B6qnr/EDrqTtgi8Zdt2574Ssb/rrt GhMOgMa1u5064Q4AAAHufZRstIWbRy/99NRjfjAECpRMNhNzOxC4xt+X/kDqSjiAOAC1iw50yXaP bzfctr/+eM7jm5+x0cSXbLz5ESQ/fOtek1l7qkfAAhrQcp17iCtecYPS1UJ1hktbztCWsl3gLWV7 y9nbAijBDkYwcRlU2fjYZorjqUxxezNc3R53NZfkQ2tieEQkCmGOViDheU1YmRJ02Ic+TO1tUmsG 9y4TDXBAgIjFeJq8uIcmYNhCVJdpoUsYBUMsXMwehoiEaEhTxS5krYtmIYU2WkEUdXSB0YtUPKMU xDiCjlnEX2rkwhfVyKZ+eQxgcVREGvPohMfghV5S5KMmBNm5dRFyDEFZiiIXychGOrIikDxAJCcp yUpOsgGYzKQmN8nJTnryk/7JpFowOcpShtKUqDzlRFbJyla68pWwjKUsZylLtyzALQoIAQA7 ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/spacer.gif R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAQAICRAEAOw== ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/misc/arrowTtrim.gif R0lGODlhBAAJAIABAGZmZv///yH5BAEAAAEALAAAAAAEAAkAAAIKjAMHidsLm2HHFAA7 ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/toc/free.gif R0lGODlhIAAHAIABANYTNP///yH5BAEAAAEALAAAAAAgAAcAQAIjjI+pqwDpTAzzVPjQ3Nl2Boah Q0pkd2YpVq1mW2IypZ5vVQAAOw== ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/socbookmark/citeulike.gif R0lGODlhEAAQAJEAACeBzf///////wAAACH5BAEAAAIALAAAAAAQABAAQAIlRI6ZYOzvApOw0qvO 3BXemX1N94gkR50jlqGq+4qh/K41OyNAAQA7 ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/socbookmark/complore.gif R0lGODdhEAAQAIQAAAQCBIS6DJTSBMTahPzOBKQWHOBGMOTuxNQWHNSGFOSqBPffR6zaLNxqZPz+ /PTKzOSSlOyuHPTiaKzSTNQmLAS2rPz+/ATO/ATC/AwqtATS/NTa7MTy5ATapBwSvAS67CwAAAAA EAAQAAAFaCAgjmQpOmiqPiqgqoeBIKzjvs6yyEiD3qnDgkCcQX4qBkNAJBQKNeBBQGUQEk+fLUgV BBSJGW2bYgS+iquR7DicA1aCYg1cdpsIKHnaFVgVDVEofF0KCgctZW8CiC9ADgORjY44lSghADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/socbookmark/connotea.gif R0lGODlhEAAQAPcAAJSltZytvZy1vaW1xq29xrXGzr3GzsYYMcYhOcbO1s7W3tZKWtZSY9Zjc9be 59bn795zhN7n5+eMnOecpefv7++lre+tte+9ve/39/fO1vfe3vf39/f////n5//v7/////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////////////////////////////////////////ywAAAAAEAAQAAAIpAA/CBxo AACACAMTCsSA4QMAAQYRKhQYIYABAhwiGJwokILBhgIfcNgAUiAHCig1aPAgMAGABBw+cCAAIOaH AwwOHPBQIMDBDzQLDDxgAQKCDhE4GPQ4wObNCx46DHRg0KACmU8rNJD6waUAjy8f3Jyw4IAGgR8F FviZAYIEmwNKUjCQYINTBwYcOE3ocSBTjhQPFhxgYK/CqgI4GFaokcCGiQEBADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/socbookmark/delicious.gif R0lGODlhEAASAPcAAAAAAP///93d3QAA/wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAAEAASAAAIRwADCBxI sKDBgwgJDljIcCHChg0fQnR4cCJFgxYHSJy4EWLHhgBCigwpoKTJkiNHnjyZUuRKky1JvhQQE8BM mjFv1tSZc2ZAADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/socbookmark/digg.gif R0lGODlhEAASAPcAAJmZmaioqJHj9czMzM/Pz9DQ0NLS0tXV1dbW1tfX19jY2Nvb297e3uLi4uXl 5enp6e3t7e7u7vDw8PLy8vX19fb29vj4+Pn5+fv7+////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAAAIALAAAAAAQABIA AAicAAUIHEiwoMGDCBMqXGgwgEOHAAgCmDgwQIaLGSIKBHDxgkaLFCA40MgxwwUJDQA4zCCSgcoA HE82SAAAg0UHDBAAUDAxA8oEBAB4nEiUJ8eZBAYAqMCgqYKnPAUQnbgSwgMHDVxqlFoxw9WsC7Zy FXgTbNSNFAVYzBpAwQGSGCNaZLAgwAEDJC1MiCA3wwIFAQwUIDlV6lSiAgICADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/socbookmark/reddit.gif R0lGODlhEgASAPcAACkpKTExMTk5OUJCQkpKSlJSUlpaWmNjY2tra3Nzc3t7e4SEhIyMjJSUlJyc nKWlpa2trbW1tb29vcbGxs7OztbW1t7e3ufn5+/v7/f39/8YAP8hAP9jKf+EUv+EWv+MWv+MY/+t jP+9pf/Ovf/Wxv/n3v////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////////////////////////////////////////ywAAAAAEgASAAAI2gBNCBw4 8MKCBxYgGFCAgaBDEwwSOEggAIMCCA8HZkhwQWCCBgcmZBRYIcFADA9EOswgocECAwUWNKDg8IKC BAoQJIBA4cKFCRMTLDjQIMOCiQYsjJQw4AGDBwoWmDQhAkQJgSM8jDBx4YBMCQCUmuCwIYTADho+ CHwgQOmBgVWvmhgBYquJCQw80hw5sIEDgRMMdMzQYILPCA9ICh7owIDICVKFKn1QYO9ACgcMpKRA YUIDAgrEOjxQ4MECBjIfBMj7kHKDhzklPDzIWuMCCLUFGsXt0CLkgQEBADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/shared/socbookmark/technorati.gif R0lGODlhDgARALMAAIG8PInASN/uztDmtufy2sDdnff786nRecjiqbDVhaHNbZnJYe/35////wAA AAAAACH5BAEAAA0ALAAAAAAOABEAAARPsMlxAgDhDCnNuiCoGI13KYggIMq1GMWFcBxyFVZC0wl2 CTuOILQJNgaXA4YQJFgOTkyBIWHglseQNlBsaEEJqoQgVamCggTJyG6733B2BAA7 ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/content/vol180/issue2/images/small/261fig1.gif R0lGODdhyACjAOchANUAi83VzbTVtIu9Uu6kOYPFatUYKf///+ZqlHO9WmK9/+Zac3vF/2K97nu9 Uousg//e9sXFc/b/9oOUUqS9Wu6sc4u9e4ukWouUanuk1YO9tL29tJy0Ulq9/1qUvdUpKdXu/9UY IINiKdXV1eb29rQ5IJSsYovFpNVBUvbu9nNzQYOsc6y9rM3NxYN7McXe1e7u3pxqOaS0e4OUSouk g829xbTV7tXV3tXVvaS0pKTNi6S9Yu6UKYO0c2K07mqUOXuUSnOUOZS9g5yslPb/vf/V7sXFxZSs i5ykatUIi8W9zd7u9mqkzdUIlN7e1fbmi+7u7t7V1Up7pN7e3qTFYsUpMYvNe2qUapy0lMWsc6S9 pOb//2K9WovFe6Skg+bu1ZyknKTFUpSse6RaQaSkpM3Nzebm1ZTFg3vFYqS9i+bm5ubu/4use4uL QcXFtL3Fg+ZavYu0g+6sQf+95ou9c4uke/b29pysi5SkYnOUQWq05qze5pS0i5SknMXVrGqLQcWU c3O9/97e7t4ppGq0/4tqSovFaqTVi6y9UmqLOay9xYOUQfb27oOse94IlJy9QXu9Yu7VnNXe1YOk c+7u9oOkOYOkQd45rHOkQZSsSpzVg5y9g2q9/6S0nPb2/+7m5py0arSstKxqYpy9Wu693r3FtIOk SmqknN7m1YOcQXus1XOcQYu0e2qDOXOLOb1BQYOcOZzFi3OkSpTFe5SUlKS9c5S0e6zFlJzNi8VS QXPFYt72/3ukWv/u9pSsUousar3NxZS9e3uUQZy9Uvbe3ousSqSsrM0QlKTVlGK09pzNg3ucQXOc OWKk3oOUaoukSoN7WqzFYoOsSnuUOWqLMea9au729pS0UqTV7ubmxYPFc5ysxf/m9sXV5mK0/4Os QZzV5lqs7pS0Sou0SoukQZy9YsXeauZBrHuUc6zF3v/u3pSsvYO0g5TNg5TVg2qUzZS9tIvN/5y9 1cXm9ouszZTNe+5zxXO01f/N7u6UapTN1fas3vb/////9v/2///27iwAAAAAyACjAEAI/wAPHCDz SaDBgwgTKlzIsKFDhWTI2HlIsaLFixgzaryIKoM8awn5BfLmQYqUd82amWxGKNy8XhAOeFoD8oCg DPQ8bdzJs6fPnxvlyUuoJoila6N21CrHodgqQAj2ZHj3rloOWu8yrCHlJIipcRyYXnuWB5RCfu8k adwVL5CPZMkIBZLLaWS4ZN4C7VE4ry1cBZzwcvIWOBknBnv4JewbCG+DwYELG2ZgY0vCJW05+SDs jZBhz5P36EQIIjNcyIbhTn5hWSG9dD0ZLRPWyperRS6+kQuCo1/PDGoftujRTlm7WQ8EIUxxpIvx dnQ2GBzBCpkOXLiOqEmYQwgyXMjOsP8wGICdcWVnaGw/6C+HhXZnjueYzkqZcVw0pnC3gEsZrlla GATFEcgUGF4CCdBhSAJdJABJFzoYOMRB9LwA1AHE8EAAAXJ0SICGFx4gjw0NCcJGPcXNUod+Bw3o XHw9RCHgA4fgEiEbZSD0yRBn1IhMHAEYRAkbuLQTSzuN5HjQJ0fM0k47uPQwgoB1FNlfkghRcoeT 2LGipEBDRBjhGQloA4mDZmpjXYSxKCLQC/SEKFA//1RTgRwVPNGPb3JmUJOcgAYq6KCEFmrooYgm quiijCqKhQuvhFDCGG20sUgbMUSaSytmXeRHEC6UYEAuLqQCSyWwLBLDBx/EsMmFisT/USR8YyyQ Sy49oKhMFzSk8FAZKxTXTg+5LLDAGCgWx6uvDwUQ7JPEGjuGFU/uSsNEzT5gIDIYoLAAChgYiEsf X1B0yw/LpFLMONdwkFQqMqTiDCijjHLNWJZg4kotB6hBj1AZSOFBNwekkscyphRzLwc72FaHK22U U869xTxjyjKuBJdRGexUewZ6zxmJ4sfHtVMPFgpJwko9sdRjnJPxiRyfM6+sgOIRCznRgzJO1hNz cSy7LPKT9eCs0BR8GBghf1CO2YUm4EWIzIQPwZDKKYTowYsp5DxT8TMWp7KMHkykgu1DXwDxgzDp mmKKxWCbkorYefzRAp8+TUEDHUJX//vkLJOUYtEIdXSRLNFH1rNCJ/4MXriwkxTynjL19DDE2Q8J coR3AsRRLKkCHMKHMZg3qhAxfdxDQAWRVFONHDSoog7eO80BxzkNKcZPP7sLJEFDlKhhzRpORKEG JRts8AkUMJQhyAhq5NgLPkVQj4/12FdvffXac7+9PQAMYg8+pR8kiPGSTFGGESOMUMYURphu0Z57 ym///fjnr//+ipaiQRzCSEXCFGaCAYxDHMUwwQUuwAtXNIEM8+CfBCeYkH78biGS0ADb8IAEUAzg GuWoRRpkkIU0UMBe1yjGBSwhDH0IgIIwRNQtWpEHYdQwXQJ0G9xUCLYLWExuvOACF/8WIYoqGEAU PAAEM6YxDbal4gEn0Ic+jmAGg+DDE9z4BDGIEcMuAkUGrRCGE91WDIW1y15MKQcFdjCKBAixB8NA IcWKYQpLpEIVqwBCIkpBv0gQ4x+ReEIv1KGOQG6RkF5MJE++4IoaAkGAF1AYIuzlrqREYwfRoEAY EBGNaESgk+66FwJ/uAwgCMMVQJAACBTJSkNJgoZ5eGQO31ZGX7BLHPdiVybG4Ysy+lBuyyhlHlzh Chi08pimkwAwUtGKRBAzD8OEZiNd8QdnXuBuyMzmoTxBhgPcwE0b4Qcw6JGBDKRDECCQBDawYQMb LGENgkiHPMopj/X8hBLQIEMoFKP/zWxa4x0kEkgAXKGuddFxBh8Yw2AI4Q1v6EMDnYlLOKqQi6+4 iwMpXAYeDOIJnPwEBHuIBwPmQghOEEIu8YjHPEjAkHlgY6QMxQte5BIIlf6JNOCAqWe8MdNA1HSl C5lHTk+KF2+Eo6F1iQc2WMoXcPjUM0dtKGFquoclOMQGGXiIH/AAhGVcgI8GAUUeniGOJzxBHJmA xTQYsRN+aAUjdjgCHZ6jjDaUoA1PglIX+gAFhXhiCEI4hA400YZXTAIUHIhFhJSxIoX44whMawdh X+EMd0DpOJNQTkL8MQT+YEcT0HgFBqDWn3rUQbMJYQEfDmGgQnwrBtYp0AO+dJBu/6hCTmbwgx8k Qbuf+KkhUDhRcXrAIoUEl2isKIgnjgA1HVggSAuxAx9shAxb6McObEBPOyxAW4TEVROzwAUrthNX ++CCDi1giD8eYCVWOEEgLIiaddrRhe9QtwtFEhMyYjGfA9CDYEDpx4YI0AZAVGpDPKhGiEbUrEk4 Bz5P+hiKZrGC9C5EDX2YxXe+M1jq4qcM/EyIIGhggfvk1UpdmER3D6IGEn/2F4jwBXbg0wgL+9UY FjCQCZ5AhAg8okBxCAVC/ttPEcGmIdzYBxyaMAh8kMLJT44ylOdAClJQeR9WxvIc9sFlLB8gCu8z ghFCcYMRhCIURoCfMYyghFBIR//JcIiznOdM5zrb+RIACB8c9lGEhbRgzRswQvICHYoyGKNxRU70 MctAixSUL5u00EmkMYJoRSMqDSX4QCosUQxf3GsYSAH1NcZRDGmM4QMueFVDGCGMEqBgGd/IxKdH EUqMptAULjBADPzAkyM86UjnyWvLKKddZfTgvQrBQrKM07K8Uu7XQpMSQ7AwCxTpym/XBlk7WAFd heRAvjqAxJnawQVDnIk/UhOCjRdiDR/oYRmcZlclT8hGjCLQFHo4RTEbEoBEtM2MSKkXvWxdMVOc slMbKQNxQCZh+LxMZDxD2UICsDMIw8dnEI9Py4r2D4bgYGc+89l5PkayM4S8Dh3/x2DSxKQNB6FJ 3PJFxhEe/RBU3EIGePAFFljgBEb0ViPWiAAgloGOLEQCUJW2tNIpUoF7ECILr8tCHMKh4KVb/epY PxQ0QqExQPUDGFGExyR4AY0xQAMauTgGAOyxC8X0Yg694EYvigCBXtgdHwewuz+4AQFu5N3ueceH 3LNuaTNogA/CSNi9RjEAW8gAEVTYQTloncJnSKMQcIgH4ZeOCmYmIggxiMEYQk/60AOh9DH4Qwxy AQ1MyAIPeCgju+4lymJkwgtemIEG0iGBn28+kYyE5hhNEclO0/4aohb1OBDEBWlUTBWNYMIpYAGI abShGsSo3++XLglqoLJtA/w0/wjrFQGzPiESw4hGLSJPazl+TW6pEMYprmDM7VvdDM5k27/LeA1x iIMDw1BJ7VcvtCZqCFRwYgMEwwQE1uB79qd0qAAEsAQEXYVDOWQJdSRAcxNMpWRDeZAIqTAaD5h1 igAGtAAo/DA8a+AJISYoUKACtCBkIxhDa0BO6SCCB7AHDXVSDMVQedEaBiEIqgBQM0h4qkAP/HQD dzA3dfAC+fAKneEBKVESJiEwDZUBqBYEGjhMtyAQgvAOR1aEyNRRACYQapAHpgBCO0AFTCENuUYL O+gN5qAPEaUARZQKvjAMmMSGvmAKeVB/BvEvG7ELPHVSbxEPqLALVQUCDMCDyf8QDgyAEI1xUnrg GZaoB3FRiSdlVEwlEAwQDjzoA4aYNZe4ieFgVQbBAHERipaYiaPYEquUip1hiVkTF6K4iqYYQQxB Ce9ACX5GDQnjC/cWBDJgEKhQKdUQAW3gAm9gEHYgBq6QLssQBMIQAA54AN2QVTtxAznQCO9hWRbA Bp0gIw/BjXwQC5qwJqCABfFTjkPQCMFQD5rAM7ZwB0ZwjQYRBVjACsFQHDwTDEewYgqhBjmABYqF DIdwCJtwByzALA0hiDvRFUfxCJsUBo/wDdPQjDyRAaj1EEZQcSBjAewQB6zwHsKiDJAgHQdRBtXh YULQCHxQB1XCYeHRCQjBMSb/hgsWEAcPwAqs8DO7YpMryQqkBSUWwAps4JNngB32MQsSZxBqoC2x pQNWcAVjMAbUwAVnUCARcgQ4KBBC8ROMwEwE9UitMA285VuxqF4PkFezIJQKAQx8YzIPgC1DYCPY AZcJQR0bNl4C4WvocQZPmRABsAjVkCt+eQB3cFntMJgIQR39gQvssB7xpV+4gAaQgAvaoA06oA1o oCYGom4clQFf2RPEIAcfQgDVkHJAoQbayBBHoCtdoJcIYQRzWTQG8W3YgQtUoxAtkGPgMXMC0Qlc 0g5G45vmASVsgC2dUBxFcpwJUQYl5h8PwCxGsJVTqQ1WAAnaQAddoA1QElvI/8AHmgUCr+kTAsYD eOI6eCIHCXYhHeUQnzAJwlIcFtADK9ADdCBsitORB/BYeNlhFsAHttAjgzVYD1BcAuEPNOAkl3UG PeCTD2YlK6Cg/wmYUPIfFrAM7CAE/vGhjTAlCJEDscCV4ZYAk2ACPaAmESIAFtCOAnGeP6EOqdkh qMkDFSAnrmkRgsACd8AGbPAADIlsFAEFRtAJfHAEWIAFG4AKFmGkWHAEUrpz9vQQRjoEScoHQ8AC FtoQnlAGOSADvpAJHMACUeB76RCG2SQPXacQvaBkTAYBRTCncgoBdnqnfNd33LCnfLqncTd4RiAI U3ADZfAJwaMG7RMKdqAGUP8wBXbQpT+RD4OQDzHREKGgBqHgPsvjD4ygBmrgkAbBkUWWphXRglaX dGKYqqq6qqwqQWRAC2Tgn63KE6EABhRBCSywDK2gAiJQCC6gAsvAAuWyEf2Qq4ngAqL3CmMgAq0g A8NKEaEAq77oEDfQB+zQBawADYXQA1bQA2wgOBcBBTmwAhawAmfXBV3grTBqEdbQCStAB+YKDdqQ rnXQAqb6EJSQAw9wBmOCHUJwBKWAqg8BDCIQArmwCNLgfJnQaWVURm3wAa/QCl34EIywCjFgAGNA Dg3raQ1LR5iQCyHgAmm5EylAAxGmbeLmMSDTA+uWECYrLBvXAwPgMcdhbOv/qhC+FmEpIg25crIu 0wPgyhB3KZ4N4gJjoAJc4ADyJQQq2RBOQFHL4DWzVg47ULWTxwG8JA25UAIZ0xAyQFGVwH9xRLVV y0YoVAyWsCrCwFYacQPvQXLngXHDdrImR5sCgQrmETTahXHaRTJOMgt3sBBTsDJ7a3IQxjPMFjRO eWFJI57twJ24oAvXgZngEVu9uRBv4ArTQEvIRwGgkAro0ArQMAkndA29JDZ7RDtqIII0EI3qkocg 5Au/AATo4ApMgVF0JDau8KwYsQYrEGyI67M0qwx0cLMCkQJs4DcmEx8apyv2YRxdMB4KgV15dXEn CXHV2wX9hbNcWSBnMK/c/7mZXWAFU4kL0tsQknAFnHAK5KB4x1d7z3A1etC1DlEKiRBAtDR7tEdq uYsxF+ATajAJ2UY0xhEfxtEDTXthAly9zhYzH0MHxoCP/UKfF1fA+yksH9MFl7sQMEAD3UsmZVcI K1C5+7XBVWMC1HAFmJg1qnAKeoCJp4AHN1URlCAG3hdLbMM2wwSCvCXBGuEJI2AELMACpdACfbUR KdACLNAJWNAJpUCOSKzEWDAETjwCPswQKRAAQ8wHWmAEbTpBkQAIDXAPWZAFTkcG2ccTRZAP56B2 x2AP9gAH9oAAcwzHdnzHeJwPcKzH9rAPvVAGG+BmaCZobWYEYFAGQbwBgv9gDJ/ADdfzyJAcyZD8 ZNdDyU52PeAjPqQgsAaxZmAwZkrQAu4DPwKJP5EwhDxQYG0gCm2QBXqQfVe8qhf0e3VCAIBQxtXA ybO6y7zcy748QbBqvIFiB6jwAi9gA2XQDVX6y/kDpkoAFFvAD1uwC1tAAligD5MwDQJkCRfgBUiQ AGSwD4CQAWMAANuwBf5gPXU3p9ezzviwD3Mwp3Nwp+nMzsy8P7eAzQJke0hxDQMQR6GUQsVAdsfA pve8dGDXNmJwB8PgAKEgzqHwBpE3eaNmMcsQRbF80IliBy1wAdSUCM5ETMT0B61wlmLAa1ugDwSV Cj3wDbhUSWxEASRkAgX/Nw1xwHsajT9p0AquYEPCUIEWCH/AJI1dNQYG8AEhgAAPTQtvcwHSYHlh ky4aIA81QAz3mtOIwmqNVIGz1LGm23/9x7DSwHxYQwgKYAw8kNZyMA/zsAfpoAXAkA29l9FYPcxA 0EgBhDBeozC4BGr2Ui+VxAVuJA3s0kt0ZAmNcAqLMA3UkAr/6Ud0XdeCYg0LGExkBHCAXX5mNQCC DQlUKzGUN0duA7r65tgHQD/0c9p84hvaJ9mC4gd43TZ7jXxIwTAUQAVhEEhmddtlG9oCbdHCdAXY 4Nr6gwd/EEsI8zYcgAiIEAHOHQ3m8EnOHQFh4EmdFAHDIGplFNUKmAjF/7gLbD0PIAACu0DcjeIH NPTT4Md/uLR474tC7NKwo92BedAKTmre/GMHqXDcYhRMswQ2KtSxKoSB803frWACkY3fi2IHoNAK /O1IXVWBES5MNuQKzpQGCq5oUIAKwFALMsACLYAKgJjhXmQHIrC9/fQJtKAEtkriCpFPKiCrGeEJ kpAO5FROOF5O/9INawAoakALgnCCLq5eGrEG8vAO8tANowECI2FUO4gN/OQPajBPGQAMV50Ra7DM Q84T6QBQqDoP3tAM4TDmnMAJHkAY4aB5CbEG5VSGW246XS4J/OQJo7EPSkAYVCgwJvEOUsBQ4DDH yjAbQIAH0HXka/nmh/9iDRkATgfAAkGghWIDegaQAZ0xi6DIg2YtCgawCPx3a64AXYo+FHIizdZg DdGMEfxAArsw3iCwBCQAhA+R6qs+3q4O6w7BD7Mu3q1OAlceErMOAuLt6r3eEP/k5mKjMLc70LlQ BaqgAJs4h7PYALRgANAga2vIRtdgCQxIIXGyE0y+gyjViG2hB6AIivHQiQLx7eCuia14UuHACXtx EIx4VKxIVLQIivFuELtgF5jO7nERFw2l5gaxBJ84i7hIilDVGeBQEeaEEJKQBxdwDRTQSTuQQqlQ BaLQAd6gAAowhx2gAISBAqKwDMhuteKg7Wx7EA2fEdbQGKsIidgQ7Iz/mIkBjxDY4A1vQfNZE1G2 CBcMgIM3X4grfIuEQPSbwQCw/gINZYtFTwgN4BkNsIpvEQjorvSFaPSjKIqbEQi2nhA28A5+NTfI Tmvj4Ieo0AsHgAAfYAAEsAAhYAALUAR7AgquMEDjcAGzcd9r/g49/sMg8ALgoArN8MJ60AyqEPPl nTt/Tw9MwAQacA8ecA82AAIzHBJL8ALy0AxMcA+QL/mU/xDWMA9dfgr3wAQeUCGf7xAkIPrSdw+q EPndAALDrvIBtRBpEI2WEEyuIAbYsgZdFQ1EQASPoFa8Nid+YAKpgAdpwLsL8Roa0R6NACXuEAfQ IAaaYDIrMASlaRDt/8EKuFAjQqAJR4IMmiAEfaDl3D+uUIIekzAL9lEPdHD+DZEDyYsdZ3ABS1kk rCD/DGEED6ADAHEIWSxobTYhG/igzAGGDR0e8PSO0kOKDe1Y63cg4wFrQExlemTO3CNxlYL4qZiy oo0MKlMOsdBOpswzk4S0wyWzXpc+Gx12OnMIlw5kNMY0QoRokw5cyHDRSEERZk6qjQqx0XSGars6 UR/msIALlzJcmmxBs6WJas6uFI3EQUgUV4wFC8bMQkYUGZsoKSk18+dS8AFUQZ6lSpVJ8bRK0275 HFxRTcvIntjUmzlrBYsoUKYoqtNFWb0zyhpBaejvgVAdah8oUpMCSv+ZO0KQqd07JfUDmTnPNGIh 6N/sI2GprhDksA/Ose3YhEKV4lOZ4msb6W6Yo6lebVwccPGeIEGXvMiElKJo7V3kwWlctWo1A/60 aakksHc5OTIWzKVXYH8ohTpkiqWeIxpiIaim4uiroiGGwuWQIwI7IIdZcHIOwIeO+CWTYHA5kCEW ZiELFzZGeEkrnI74h6EyzihPB23oSMCKLhKYBZIEtiOKDzUeescT/ASzAwth8ghCmAtQgWxIirqh RzBr2GinQDoCUEmNFZQpjY0vDvDnCE2IOsMIlVLgY0xk4tDNkyN6s6CFMyfpoR5letAtTOYsMDMl O9gYSxlWsMtBL6L/mNJGxqZwOQOSvIiKJQeHMkjOycH++adJSyuSJx2XLFNGJlawTEnLUE2b6IAj yjsDvZSgELO1OH5UFUMLXK0Iii1lYoPWN8e6VSVKWBELF1ZQEXGo8nDR5gw0upAJDUMROkOJhoCJ ctOUquGBBwII6JYAdbRNKYNUU2LBglDr+a+iFC5rR5kuOmnIiGCcWnMhiuzoY0yxsGiolJhwYkfO fWmoxzeAGWrBOGP1fchNsmRa+AA14NKrHUi6gAQSXbrQBpKmyjtCSIYysIZciuT4Vo5qXmaZB2I0 1VaSbFXqpAvM2qlnEham+ESNDdgQTaZZQkTwjNaaYsWYFlC5gYUj/2CE8I6H0s0p1BU6aUGQEVh4 4Iwq2zkDaRHDIsu0TspQYwqpuxArVBYdGgGu8rqDJOQERI4LmQdQYygdeVR+SB1v5QAkgixckEMO Hqoh/KEMaFVphBUwO/VUAuth1+CH1KChKX+REcgpNR/w3CE1JsGQKmVOVXGF1BtSow6txjI2Al/U aq6RPh8KMxaEEJrkCSIQoaI8CySd9NzID6jAWwIAmf5bHsZ9nqFu5KHQpU+GWMECzDGzYIUhKlWJ kRyOEEIspxh9YAhkXbIjBzZYudA3CxoZgnI/7Y+JMoJBE/5pKCVGYB8uYiEORIgjDBYYwg0oop/s NYQY3fJWtypAM/+VeYIyQ/KEHexQQRLip0UlpIgNBodChvTDhSw8mf9cUoR9wDAlJrMhQ7jRPRLK oxs5BKI8bOCSfVwCAEdsQhKS2AQmJsGJTlyiEpnIxGM4oopXHIQ/ykCGUBhjA2AIBRdLQQYvdnED oaCFGvJxDja20Y1vhGMczzEIJJ7DHkVIiTGMQYYNiDEUoWhBKDZAEXqAAIg5TIenIoOPffDjkJJw nkYgAqYDOLKSl3RkJjG5SU1msoj7iIolXeIPfniCEvyghATsADiH2CCShyShJH4IS1rW0pa3xGUu dblLXvbSl78EZjCFOUxiFtOYx0RmMlVmBFoMUpmCoYUnBAGNZyb/kxYowo8aAgAMYPhhfpHrBw5u AQoxgCINfoCBk6DhiTLQgocqidoR4hCHI+SgBa9kDxRKoQUs8AELLBjBO4dkDWDcQgibwEIpJHEf bVHCCFoYAhb+WYYRpoQMtAiFS4CRBxe84gMf/UAIPvCKQgQBV0NywjJaEYMqGOADVXhFFT76ilbc ooSKaES8rFCIuoyBDppoRw+OgM+KBGASorHAGHKBAheMpR49GEJFIyOJo8pLqbmIgTtk0oM7MAI/ ATiC8AYCjVxA4xYIEcIRWMkePrhApjF4RjHIIddifIMcLvhoK6zGHickIgYGQEEbipGJYsQ1rpZI RS5CIII0PK8M/43IyUwSmwsXuGNn8hqCYFDBuswUIhe5WAbPZILZwWx2tGQjay5mEC+ytaMLe83P A/omgMQuIBdt0MSywMCeL7TiA6C1xGCvMdzhioOw0mhDCMbAjHQKJg0q+O03iiHc4Q5juNM1RSpK 8IplMFRbijjBTMQmtua0VrT1eIBAXdSDUJ1hZztrbajIhl4OHiAA7AhVgdw7kyr1ZyYPwCFFJGG3 vLSDCwnoji7Es6PhHUGqKeHHX9tgiuleYxijwPAoODCK4RIWFh8Ywyq8qhI/iMAAbZhrdTlQjlGw mMPXKIYvnoGCErCCXGqArE7GG6+diY217bAAC9yV09ZirjSk4f/xTOQl5IpYRsliK1C8fHwh0c4L wquKi8byhoseFIBj2ugbLpinklKUoA2W+Mg1MLyDHUSDClTYgYZhXIw2xMAVwIBMN9B3gRi0IRXF GG6L2xyNWrBZzsUwBSxckIdvOqkMAxsvkpVB5SOLbdIVoxsrerw5Lo2WNAE0UEokwYqZFIhL7aVJ Oy50ZLM5RBK2OdT7cAJmpzSrPMjgg3NdsYxUPCPQ5diBClwBjVbggQIcuMY4ioEYVzR2Dd2Adgak IA9B8CMVeUgFha+x4R2YABrEhkYwhmHd6S5DGK5g0qYEwY5Ui3c0ZHs3a7swZodMgb390Vy8QzUJ FdCBZ5mtiL3/893f+RpNyqNpNe1YcWsZWUEbaHCtjQQwrYQ/JACnQEcl0qxmYNdCBmp+MaJNAQRq oARnu07FLwB9YWDDeQcsvm528wAElQ2hP0iGN5Kj3NoVyLAhWFi1nUqT5P3iuwfYrIgxrGDq/kaa JqduByuQTpFCLUsbV+/YjJ4Va3jMjiL94EM4TtFrQG97wxsmLqJ5QYgrmEAw/ADCzE0R1+FyYMPD 4AC5EW3uP0iCcH3oMb7jyzOxtUslfbDCaE5d6dNipgcQS8kRitZezLWWRPHqgdcfYgxlLGvBkODC 1QWgLCH8TiUZkcEpCHGKZ8S1GOMYrrIRbYm1n8LtkbmAK4Sx/4y5TxfQvn9Gds2N7ucZNdX10G+S e0DvlPSjDJMQ+qQ7rfh20MHBkRkB9NuriTaMYRLylRcNHqwSSTxAL8hoRC4WgAJoDC8WJRvSF2Zw BSYogAmN4H0qELuMSSQjHKnwOZdABSBwBSBYBl7LtlTgtWUgwDt7oezxhA2ggR6ggy4IBjpgha1B n3yyH1boglmYhS6gA6GCPPagBPvpAWixgjMYwT7QPMHwBEVgnzPovhiwhWA4ghdkDz9IBVe4gis4 BbE7hVOYhBaor8GQBBMAgkTIA1dwhT/ANmAYPxY6wmoSJhd6QMKJhHy4B0IghHXIgkioIAiwBzgo IVYaP8+AJf9G6oXB+AQ7UAMoeDB/SJli6gcC8IYccJlqkIMsIIQNyEJLwQd7MCIAcIRLQMRETMRB YMRLGARHhEREZMRJfMReCIBQKANBAoMz2oAxUoIu4iMyIIMvsIcnMsVTPMUmOIYkuiIlOoYkOAYA kEUASIJzqKGK2ACM+iMWMII/EiRjOCFhioR76ANAkIM2OEYeoAUmmJns4QYYgowAqwh+oMZqtMZr rEZOuqRKYiQ7ECUrHIxeMIZwaAMeyILGAQQPAINMAcd2TKZ/IAAwSAYf0AMFUIVqUC931Mdh+gd1 IIZg3MeARKYqFMiCNMiDRMiEVMiFZEh9hMO1asiIzCFoMIL/ACQhGAAGfdAHcJCHSziGj4SDGvhG iQRHitzAyKHGA9gCRtACfYCHZZgGWEiFUAADTPDFVwAAWjAkfIAARtqHn9wHfMiHOcAHRsoHoJyD fRhKCADKfGhDkmzHLUjJTdCHSVgGNIsrJDCBHiAHJBBFq3xEcNgCqCRLl2CEBziBCTAFChOHbRuA HrCuYYA9tXuFS4iHkSzLsuyHIziBGei9bRsFBygHYMuwmDOFYxCFPcjLxWQIP5AHXsi2YhAHDhiA IwAEQSq0OEO2a1hLV6AHRWLMshQAfQCCVMCDUPCCcRgGUPDFWzA0ZMsEaUgFIIAHYAhNgYQBP5AB MZhNIChN/zFIgwDACIbYBQ0QhlRAgmLogXHAMApgs1oIhTvIO2WzhGXgBX0wg9tsx1JYBmooBBdw gVZog+8kwDZwhRhwgRgQARdIhYycOVn4hm/IBAsDzG0TBzEgAyQwhQPUhwAgSO38pVJIBCg8Ehdo gwNFUARdhgPlKPNsqQ+IgTq4TDIIrhgbB8KavWXAADJQhC/4TwDlJRlohSQRht3jtexayxRN0QRU QF6QBhQIAcCyB1pwBl5DLOGrjzhwSZTwChAtJklohWnQPQRM0dbzvSP1vQuQhgPrAS5QAGhYAHAh AD9jBw3YSH2gBz5oAe86gE/4BGL4BE/gBrz0UVwS0Two0f8T7b0YI642La5xODAukAZLuAdvIIQL yKBqaC4sDMQyLSYZIFA1db02jUs1o88EODBpkD1TqAReOIVl+IEfoIYWeIJqAEg/PSY/YMLdQwxT uAALrS6QA4VRiDPxkAVIuIZyuK5iuADEOgVeCAIn/JF+IIYnaJFMwZR+VIdxuVRMvaUezAMi/dS2 pE9SjYAIoIJy+A5ZcAAMWzFDna7gSwVZOAWSu71+4AZ1eAJu4IZt/Ydt1VZ29FVcMoNNRcBPzQRi 1bByiIYncNdIcIAEADZD4zDrGgdfQDQFXAaMA4KK2oh/Hddf8gNXQNMTjStfIK41a7NIcNcniIRR iAY2YzH/tJuztVTAIzmFNfjQgMUlVBhRTo1MX4C9DWsx50SEMIiASIiGiH25wlzVw1BAAhQGGzAk jiUmO5DZA8w2U+AARIiGCFjZYz1WczjWn40Aoo0ACti2ZCus7FLAJryAAwCBXfAEfkiZNbDZX7qF REjTTmVTcVBNCkCEcRuFMKCCUaCAUcA764o9fLVYc8uDVvA7q5XKbMxaX8q9mVPTTy27QANMDeMw ihWH6WpVfQUCYUgEGbhbZAJWE8021wM02PNbtr0GsPU9i43ZPKAGMVjcZAKFVjgSA+zUNT1SfD3S CyAHU0CsmD2SViiFje1cXfoCJ0RTAyTSFLWE4NPdtVxdVAaMO1dIhFSQxtg9JjVIhVbQvdo9QARk Xn3tTTR9DzyoQ+IFRz+YAORtQjRFU2E43CM5EicE3gvwO+oNSBeSBBnowT9A3kRohURwwgtggUYj 32MKCAA7 ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/math/sim.gif R0lGODlhCAAGAMQTAPr6+t3d3SIiIqqqqtTU1AkJCaenp1paWq6urhcXF3t7e6WlpZWVlVtbW7+/ v4+PjygoKAAAAP///////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEA ABMALAAAAAAIAAYAAAUYoFNEiiQRzBEATTJAyGJKhvBIU67vfK+HADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/toc/rarrow.gif R0lGODlhCgAVALMAAP9YLv9MTP5YL/87O/zw8P9TKfz9/f9KSv9KHf9UKf/x8f83N/8zM/8zAP// /wAAACH5BAAAAAAALAAAAAAKABUAQARA0MlJEWt3JSVt09yEgFR3nV9BAGHpsK75bRWaqd5NGMZI x8DAr3SYtSTFzDCJMTqYqIEAmtoxFyqeoUiiCI+TCAA7 ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/toc/uarrow.gif R0lGODlhCwAJAKIAAP/l3/+ehv86Ov/Lvv8zM/8zAP///wAAACH5BAAAAAAALAAAAAALAAkAQAMW aLrczkMUEp4BLs5NrY1VoxFTOHJlAgA7 ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.jcb.org/icons/toc/dot.gif R0lGODlhCwAJAIAAAP///0JCSiH5BAAAAAAALAAAAAALAAkAQAIMhI+pGb2PWoC0yooKADs= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.jcb.org/javascript/ajax/xmlhttprequest.js /*=0A= =0A= Cross-Browser XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.jcb.org/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else if (name =3D=3D "margin-right") {=0A= e.style.marginRight =3D value;=0A= }=0A= else if (name =3D=3D "margin-top") {=0A= e.style.marginTop =3D value;=0A= }=0A= else if (name =3D=3D "min-height") {=0A= e.style.minHeight =3D value;=0A= }=0A= else if (name =3D=3D "overflow") {=0A= e.style.overflow =3D value;=0A= }=0A= else if (name =3D=3D "overflow-x") {=0A= e.style.overflowX =3D value;=0A= }=0A= else if (name =3D=3D "overflow-y") {=0A= e.style.overflowY =3D value;=0A= }=0A= else if (name =3D=3D "padding") {=0A= e.style.padding =3D value;=0A= }=0A= else if (name =3D=3D "padding-bottom") {=0A= e.style.paddingBottom =3D value;=0A= }=0A= else if (name =3D=3D "padding-left") {=0A= e.style.paddingLeft =3D value;=0A= }=0A= else if (name =3D=3D "padding-right") {=0A= e.style.paddingRight =3D value;=0A= }=0A= else if (name =3D=3D "padding-top") {=0A= e.style.paddingTop =3D value;=0A= }=0A= else if (name =3D=3D "page-break-after") {=0A= e.style.pageBreakAfter =3D value;=0A= }=0A= else if (name =3D=3D "page-break-before") {=0A= e.style.pageBreakBefore =3D value;=0A= }=0A= else if (name =3D=3D "pixelBottom") {=0A= e.style.pixelBottom =3D value;=0A= }=0A= else if (name =3D=3D "pixelHeight") {=0A= e.style.pixelHeight =3D value;=0A= }=0A= else if (name =3D=3D "pixelLeft") {=0A= e.style.pixelLeft =3D value;=0A= }=0A= else if (name =3D=3D "pixelRight") {=0A= e.style.pixelRight =3D value;=0A= }=0A= else if (name =3D=3D "pixelTop") {=0A= e.style.pixelTop =3D value;=0A= }=0A= else if (name =3D=3D "pixelWidth") {=0A= e.style.pixelWidth =3D value;=0A= }=0A= else if (name =3D=3D "posBottom") {=0A= e.style.posBottom =3D value;=0A= }=0A= else if (name =3D=3D "posHeight") {=0A= e.style.posHeight =3D value;=0A= }=0A= else if (name =3D=3D "position") {=0A= e.style.position =3D value;=0A= }=0A= else if (name =3D=3D "posLeft") {=0A= e.style.posLeft =3D value;=0A= }=0A= else if (name =3D=3D "posRight") {=0A= e.style.posRight =3D value;=0A= }=0A= else if (name =3D=3D "posTop") {=0A= e.style.posTop =3D value;=0A= }=0A= else if (name =3D=3D "posWidth") {=0A= e.style.posWidth =3D value;=0A= }=0A= else if (name =3D=3D "right") {=0A= e.style.right =3D value;=0A= }=0A= else if (name =3D=3D "ruby-align") {=0A= e.style.rubyAlign =3D value;=0A= }=0A= else if (name =3D=3D "ruby-overhang") {=0A= e.style.rubyOverhang =3D value;=0A= }=0A= else if (name =3D=3D "ruby-position") {=0A= e.style.rubyPosition =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-3dlight-color") {=0A= e.style.scrollbar3dLightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-arrow-color") {=0A= e.style.scrollbarArrowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-base-color") {=0A= e.style.scrollbarBaseColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-darkshadow-color") {=0A= e.style.scrollbarDarkShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-face-color") {=0A= e.style.scrollbarFaceColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-highlight-color") {=0A= e.style.scrollbarHighlightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-shadow-color") {=0A= e.style.scrollbarShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-track-color") {=0A= e.style.scrollbarTrackColor =3D value;=0A= }=0A= else if (name =3D=3D "float") {=0A= e.style.styleFloat =3D value;=0A= }=0A= else if (name =3D=3D "table-layout") {=0A= e.style.tableLayout =3D value;=0A= }=0A= else if (name =3D=3D "text-align") {=0A= e.style.textAlign =3D value;=0A= }=0A= else if (name =3D=3D "text-align-last") {=0A= e.style.textAlignLast =3D value;=0A= }=0A= else if (name =3D=3D "text-autospace") {=0A= e.style.textAutospace =3D value;=0A= }=0A= else if (name =3D=3D "text-decoration") {=0A= e.style.textDecoration =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationBlink") {=0A= e.style.textDecorationBlink =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationLineThrough") {=0A= e.style.textDecorationLineThrough =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationNone") {=0A= e.style.textDecorationNone =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationOverline") {=0A= e.style.textDecorationOverline =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationUnderline") {=0A= e.style.textDecorationUnderline =3D value;=0A= }=0A= else if (name =3D=3D "text-indent") {=0A= e.style.textIndent =3D value;=0A= }=0A= else if (name =3D=3D "text-justify") {=0A= e.style.textJustify =3D value;=0A= }=0A= else if (name =3D=3D "text-kashida-space") {=0A= e.style.textKashidaSpace =3D value;=0A= }=0A= else if (name =3D=3D "text-overflow") {=0A= e.style.textOverflow =3D value;=0A= }=0A= else if (name =3D=3D "text-transform") {=0A= e.style.textTransform =3D value;=0A= }=0A= else if (name =3D=3D "text-underline-position") {=0A= e.style.textUnderlinePosition =3D value;=0A= }=0A= else if (name =3D=3D "top") {=0A= e.style.top =3D value;=0A= }=0A= else if (name =3D=3D "unicode-bidi") {=0A= e.style.unicodeBidi =3D value;=0A= }=0A= else if (name =3D=3D "vertical-align") {=0A= e.style.verticalAlign =3D value;=0A= }=0A= else if (name =3D=3D "visibility") {=0A= e.style.visibility =3D value;=0A= }=0A= else if (name =3D=3D "white-space") {=0A= e.style.whiteSpace =3D value;=0A= }=0A= else if (name =3D=3D "width") {=0A= e.style.width =3D value;=0A= }=0A= else if (name =3D=3D "word-break") {=0A= e.style.wordBreak =3D value;=0A= }=0A= else if (name =3D=3D "word-spacing") {=0A= e.style.wordSpacing =3D value;=0A= }=0A= else if (name =3D=3D "word-wrap") {=0A= e.style.wordWrap =3D value;=0A= }=0A= else if (name =3D=3D "writing-mode") {=0A= e.style.writingMode =3D value;=0A= }=0A= else if (name =3D=3D "z-index") {=0A= e.style.zIndex =3D value;=0A= }=0A= else if (name =3D=3D "zoom") {=0A= e.style.zoom =3D value;=0A= }=0A= }=0A= catch (e) {=0A= /* ignore error on attempt to set e.style.[property] */=0A= }=0A= }=0A= }=0A= }=0A= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.jcb.org/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. For now we have to disable=0A= * the callback until we can track down a proper fix=0A= * (or everybody sanely upgrades to version 6 or 7!).=0A= */=0A= if (navigator) {=0A= var appname =3D navigator.appName;=0A= if (appname =3D=3D "Microsoft Internet Explorer") {=0A= var userAgent =3D navigator["userAgent"];=0A= var s =3D "MSIE ";=0A= var n =3D -1; =0A= if ((n =3D userAgent.indexOf(s)) !=3D -1) {=0A= var v =3D parseFloat(userAgent.substring(n+s.length));=0A= if (v < 6) {=0A= return;=0A= }=0A= }=0A= }=0A= }=0A= =0A= /*=0A= * Acquire table row element to update, initiate callback=0A= * to update table with Entrez Links.=0A= */=0A= var tr =3D document.getElementById('entrez_callback_'+pmid);=0A= if (!tr) {=0A= return;=0A= }=0A= var req =3D new XMLHttpRequest();=0A= if (!req) {=0A= return;=0A= }=0A= req.onreadystatechange =3D function() {=0A= if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || req.status = =3D=3D 304)) {=0A= var src =3D req.responseXML.documentElement;=0A= var dst =3D document.createDocumentFragment();=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], dst);=0A= }=0A= var tbl =3D tr.parentNode;=0A= tbl.replaceChild(dst, tr);=0A= }=0A= }=0A= req.open('GET', callback_url, true);=0A= req.send(null);=0A= }=0A= ------=_NextPart_000_002F_01C8636A.6351FD60 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.google-analytics.com/urchin.js //-- Google Analytics Urchin Module=0A= //-- Copyright 2007 Google, All Rights Reserved.=0A= =0A= //-- Urchin On Demand Settings ONLY=0A= var _uacct=3D""; // set up the Urchin Account=0A= var _userv=3D1; // service mode (0=3Dlocal,1=3Dremote,2=3Dboth)=0A= =0A= //-- UTM User Settings=0A= var _ufsc=3D1; // set client info flag (1=3Don|0=3Doff)=0A= var _udn=3D"auto"; // (auto|none|domain) set the domain name for cookies=0A= var _uhash=3D"on"; // (on|off) unique domain hash for cookies=0A= var _utimeout=3D"1800"; // set the inactive session timeout in seconds=0A= var _ugifpath=3D"/__utm.gif"; // set the web path to the __utm.gif file=0A= var _utsp=3D"|"; // transaction field separator=0A= var _uflash=3D1; // set flash version detect option (1=3Don|0=3Doff)=0A= var _utitle=3D1; // set the document title detect option = (1=3Don|0=3Doff)=0A= var _ulink=3D0; // enable linker functionality (1=3Don|0=3Doff)=0A= var _uanchor=3D0; // enable use of anchors for campaign = (1=3Don|0=3Doff)=0A= var _utcp=3D"/"; // the cookie path for tracking=0A= var _usample=3D100; // The sampling % of visitors to track (1-100).=0A= =0A= //-- UTM Campaign Tracking Settings=0A= var _uctm=3D1; // set campaign tracking module (1=3Don|0=3Doff)=0A= var _ucto=3D"15768000"; // set timeout in seconds (6 month default)=0A= var _uccn=3D"utm_campaign"; // name=0A= var _ucmd=3D"utm_medium"; // medium (cpc|cpm|link|email|organic)=0A= var _ucsr=3D"utm_source"; // source=0A= var _uctr=3D"utm_term"; // term/keyword=0A= var _ucct=3D"utm_content"; // content=0A= var _ucid=3D"utm_id"; // id number=0A= var _ucno=3D"utm_nooverride"; // don't override=0A= =0A= //-- Auto/Organic Sources and Keywords=0A= var _uOsr=3Dnew Array();=0A= var _uOkw=3Dnew Array();=0A= _uOsr[0]=3D"google"; _uOkw[0]=3D"q";=0A= _uOsr[1]=3D"yahoo"; _uOkw[1]=3D"p";=0A= _uOsr[2]=3D"msn"; _uOkw[2]=3D"q";=0A= _uOsr[3]=3D"aol"; _uOkw[3]=3D"query";=0A= _uOsr[4]=3D"aol"; _uOkw[4]=3D"encquery";=0A= _uOsr[5]=3D"lycos"; _uOkw[5]=3D"query";=0A= _uOsr[6]=3D"ask"; _uOkw[6]=3D"q";=0A= _uOsr[7]=3D"altavista"; _uOkw[7]=3D"q";=0A= _uOsr[8]=3D"netscape"; _uOkw[8]=3D"query";=0A= _uOsr[9]=3D"cnn"; _uOkw[9]=3D"query";=0A= _uOsr[10]=3D"looksmart"; _uOkw[10]=3D"qt";=0A= _uOsr[11]=3D"about"; _uOkw[11]=3D"terms";=0A= _uOsr[12]=3D"mamma"; _uOkw[12]=3D"query";=0A= _uOsr[13]=3D"alltheweb"; _uOkw[13]=3D"q";=0A= _uOsr[14]=3D"gigablast"; _uOkw[14]=3D"q";=0A= _uOsr[15]=3D"voila"; _uOkw[15]=3D"rdata";=0A= _uOsr[16]=3D"virgilio"; _uOkw[16]=3D"qs";=0A= _uOsr[17]=3D"live"; _uOkw[17]=3D"q";=0A= _uOsr[18]=3D"baidu"; _uOkw[18]=3D"wd";=0A= _uOsr[19]=3D"alice"; _uOkw[19]=3D"qs";=0A= _uOsr[20]=3D"yandex"; _uOkw[20]=3D"text";=0A= _uOsr[21]=3D"najdi"; _uOkw[21]=3D"q";=0A= _uOsr[22]=3D"aol"; _uOkw[22]=3D"q";=0A= _uOsr[23]=3D"club-internet"; _uOkw[23]=3D"q";=0A= _uOsr[24]=3D"mama"; _uOkw[24]=3D"query";=0A= _uOsr[25]=3D"seznam"; _uOkw[25]=3D"q";=0A= _uOsr[26]=3D"search"; _uOkw[26]=3D"q";=0A= _uOsr[27]=3D"szukaj"; _uOkw[27]=3D"szukaj";=0A= _uOsr[28]=3D"szukaj"; _uOkw[28]=3D"qt";=0A= _uOsr[29]=3D"netsprint"; _uOkw[29]=3D"q";=0A= _uOsr[30]=3D"google.interia"; _uOkw[30]=3D"q";=0A= _uOsr[31]=3D"szukacz"; _uOkw[31]=3D"q";=0A= _uOsr[32]=3D"yam"; _uOkw[32]=3D"k";=0A= _uOsr[33]=3D"pchome"; _uOkw[33]=3D"q";=0A= =0A= =0A= //-- Auto/Organic Keywords to Ignore=0A= var _uOno=3Dnew Array();=0A= //_uOno[0]=3D"urchin";=0A= //_uOno[1]=3D"urchin.com";=0A= //_uOno[2]=3D"www.urchin.com";=0A= =0A= //-- Referral domains to Ignore=0A= var _uRno=3Dnew Array();=0A= //_uRno[0]=3D".urchin.com";=0A= =0A= //-- **** Don't modify below this point ***=0A= var = _uff,_udh,_udt,_ubl=3D0,_udo=3D"",_uu,_ufns=3D0,_uns=3D0,_ur=3D"-",_ufno=3D= 0,_ust=3D0,_ubd=3Ddocument,_udl=3D_ubd.location,_udlh=3D"",_uwv=3D"1";=0A= var _ugifpath2=3D"http://www.google-analytics.com/__utm.gif";=0A= if (_udl.hash) _udlh=3D_udl.href.substring(_udl.href.indexOf('#'));=0A= if (_udl.protocol=3D=3D"https:") = _ugifpath2=3D"https://ssl.google-analytics.com/__utm.gif";=0A= if (!_utcp || _utcp=3D=3D"") _utcp=3D"/";=0A= function urchinTracker(page) {=0A= if (_udl.protocol=3D=3D"file:") return;=0A= if (_uff && (!page || page=3D=3D"")) return;=0A= var a,b,c,xx,v,z,k,x=3D"",s=3D"",f=3D0;=0A= var nx=3D" expires=3D"+_uNx()+";";=0A= var dc=3D_ubd.cookie;=0A= _udh=3D_uDomain();=0A= if (!_uVG()) return;=0A= _uu=3DMath.round(Math.random()*2147483647);=0A= _udt=3Dnew Date();=0A= _ust=3DMath.round(_udt.getTime()/1000);=0A= a=3Ddc.indexOf("__utma=3D"+_udh);=0A= b=3Ddc.indexOf("__utmb=3D"+_udh);=0A= c=3Ddc.indexOf("__utmc=3D"+_udh);=0A= if (_udn && _udn!=3D"") { _udo=3D" domain=3D"+_udn+";"; }=0A= if (_utimeout && _utimeout!=3D"") {=0A= x=3Dnew Date(_udt.getTime()+(_utimeout*1000));=0A= x=3D" expires=3D"+x.toGMTString()+";";=0A= }=0A= if (_ulink) {=0A= if (_uanchor && _udlh && _udlh!=3D"") s=3D_udlh+"&";=0A= s+=3D_udl.search;=0A= if(s && s!=3D"" && s.indexOf("__utma=3D")>=3D0) {=0A= if (!(_uIN(a=3D_uGC(s,"__utma=3D","&")))) a=3D"-";=0A= if (!(_uIN(b=3D_uGC(s,"__utmb=3D","&")))) b=3D"-";=0A= if (!(_uIN(c=3D_uGC(s,"__utmc=3D","&")))) c=3D"-";=0A= v=3D_uGC(s,"__utmv=3D","&");=0A= z=3D_uGC(s,"__utmz=3D","&");=0A= k=3D_uGC(s,"__utmk=3D","&");=0A= xx=3D_uGC(s,"__utmx=3D","&");=0A= if ((k*1) !=3D ((_uHash(a+b+c+xx+z+v)*1)+(_udh*1))) = {_ubl=3D1;a=3D"-";b=3D"-";c=3D"-";xx=3D"-";z=3D"-";v=3D"-";}=0A= if (a!=3D"-" && b!=3D"-" && c!=3D"-") f=3D1;=0A= else if(a!=3D"-") f=3D2;=0A= }=0A= }=0A= if(f=3D=3D1) {=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+b+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+c+"; path=3D"+_utcp+";"+_udo;=0A= } else if (f=3D=3D2) {=0A= a=3D_uFixA(s,"&",_ust);=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= } else if (a>=3D0 && b>=3D0 && c>=3D0) {=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= } else {=0A= if (a>=3D0) a=3D_uFixA(_ubd.cookie,";",_ust);=0A= else a=3D_udh+"."+_uu+"."+_ust+"."+_ust+"."+_ust+".1";=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= }=0A= if (_ulink && xx && xx!=3D"" && xx!=3D"-") {=0A= xx=3D_uUES(xx);=0A= if (xx.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmx=3D"+xx+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= if (_ulink && v && v!=3D"" && v!=3D"-") {=0A= v=3D_uUES(v);=0A= if (v.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmv=3D"+v+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= _uInfo(page);=0A= _ufns=3D0;=0A= _ufno=3D0;=0A= if (!page || page=3D=3D"") _uff=3D1;=0A= }=0A= function _uInfo(page) {=0A= var p,s=3D"",dm=3D"",pg=3D_udl.pathname+_udl.search;=0A= if (page && page!=3D"") pg=3D_uES(page,1);=0A= _ur=3D_ubd.referrer;=0A= if (!_ur || _ur=3D=3D"") { _ur=3D"-"; }=0A= else {=0A= dm=3D_ubd.domain;=0A= if(_utcp && _utcp!=3D"/") dm+=3D_utcp;=0A= p=3D_ur.indexOf(dm);=0A= if ((p>=3D0) && (p<=3D8)) { _ur=3D"0"; }=0A= if (_ur.indexOf("[")=3D=3D0 && = _ur.lastIndexOf("]")=3D=3D(_ur.length-1)) { _ur=3D"-"; }=0A= }=0A= s+=3D"&utmn=3D"+_uu;=0A= if (_ufsc) s+=3D_uBInfo();=0A= if (_uctm) s+=3D_uCInfo();=0A= if (_utitle && _ubd.title && _ubd.title!=3D"") = s+=3D"&utmdt=3D"+_uES(_ubd.title);=0A= if (_udl.hostname && _udl.hostname!=3D"") = s+=3D"&utmhn=3D"+_uES(_udl.hostname);=0A= s+=3D"&utmr=3D"+_ur;=0A= s+=3D"&utmp=3D"+pg;=0A= if ((_userv=3D=3D0 || _userv=3D=3D2) && _uSP()) {=0A= var i=3Dnew Image(1,1);=0A= i.src=3D_ugifpath+"?"+"utmwv=3D"+_uwv+s;=0A= i.onload=3Dfunction() {_uVoid();}=0A= }=0A= if ((_userv=3D=3D1 || _userv=3D=3D2) && _uSP()) {=0A= var i2=3Dnew Image(1,1);=0A= = i2.src=3D_ugifpath2+"?"+"utmwv=3D"+_uwv+s+"&utmac=3D"+_uacct+"&utmcc=3D"+= _uGCS();=0A= i2.onload=3Dfunction() { _uVoid(); }=0A= }=0A= return;=0A= }=0A= function _uVoid() { return; }=0A= function _uCInfo() {=0A= if (!_ucto || _ucto=3D=3D"") { _ucto=3D"15768000"; }=0A= if (!_uVG()) return;=0A= var = c=3D"",t=3D"-",t2=3D"-",t3=3D"-",o=3D0,cs=3D0,cn=3D0,i=3D0,z=3D"-",s=3D""= ;=0A= if (_uanchor && _udlh && _udlh!=3D"") s=3D_udlh+"&";=0A= s+=3D_udl.search;=0A= var x=3Dnew Date(_udt.getTime()+(_ucto*1000));=0A= var dc=3D_ubd.cookie;=0A= x=3D" expires=3D"+x.toGMTString()+";";=0A= if (_ulink && !_ubl) {=0A= z=3D_uUES(_uGC(s,"__utmz=3D","&"));=0A= if (z!=3D"-" && z.indexOf(";")=3D=3D-1) { = _ubd.cookie=3D"__utmz=3D"+z+"; path=3D"+_utcp+";"+x+_udo; return ""; }=0A= }=0A= z=3Ddc.indexOf("__utmz=3D"+_udh);=0A= if (z>-1) { z=3D_uGC(dc,"__utmz=3D"+_udh,";"); }=0A= else { z=3D"-"; }=0A= t=3D_uGC(s,_ucid+"=3D","&");=0A= t2=3D_uGC(s,_ucsr+"=3D","&");=0A= t3=3D_uGC(s,"gclid=3D","&");=0A= if ((t!=3D"-" && t!=3D"") || (t2!=3D"-" && t2!=3D"") || (t3!=3D"-" && = t3!=3D"")) {=0A= if (t!=3D"-" && t!=3D"") c+=3D"utmcid=3D"+_uEC(t);=0A= if (t2!=3D"-" && t2!=3D"") { if (c !=3D "") c+=3D"|"; = c+=3D"utmcsr=3D"+_uEC(t2); }=0A= if (t3!=3D"-" && t3!=3D"") { if (c !=3D "") c+=3D"|"; = c+=3D"utmgclid=3D"+_uEC(t3); }=0A= t=3D_uGC(s,_uccn+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmccn=3D"+_uEC(t);=0A= else c+=3D"|utmccn=3D(not+set)";=0A= t=3D_uGC(s,_ucmd+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmcmd=3D"+_uEC(t);=0A= else c+=3D"|utmcmd=3D(not+set)";=0A= t=3D_uGC(s,_uctr+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmctr=3D"+_uEC(t);=0A= else { t=3D_uOrg(1); if (t!=3D"-" && t!=3D"") = c+=3D"|utmctr=3D"+_uEC(t); }=0A= t=3D_uGC(s,_ucct+"=3D","&");=0A= if (t!=3D"-" && t!=3D"") c+=3D"|utmcct=3D"+_uEC(t);=0A= t=3D_uGC(s,_ucno+"=3D","&");=0A= if (t=3D=3D"1") o=3D1;=0A= if (z!=3D"-" && o=3D=3D1) return "";=0A= }=0A= if (c=3D=3D"-" || c=3D=3D"") { c=3D_uOrg(); if (z!=3D"-" && = _ufno=3D=3D1) return ""; }=0A= if (c=3D=3D"-" || c=3D=3D"") { if (_ufns=3D=3D1) c=3D_uRef(); if = (z!=3D"-" && _ufno=3D=3D1) return ""; }=0A= if (c=3D=3D"-" || c=3D=3D"") {=0A= if (z=3D=3D"-" && _ufns=3D=3D1) { = c=3D"utmccn=3D(direct)|utmcsr=3D(direct)|utmcmd=3D(none)"; }=0A= if (c=3D=3D"-" || c=3D=3D"") return "";=0A= }=0A= if (z!=3D"-") {=0A= i=3Dz.indexOf(".");=0A= if (i>-1) i=3Dz.indexOf(".",i+1);=0A= if (i>-1) i=3Dz.indexOf(".",i+1);=0A= if (i>-1) i=3Dz.indexOf(".",i+1);=0A= t=3Dz.substring(i+1,z.length);=0A= if (t.toLowerCase()=3D=3Dc.toLowerCase()) cs=3D1;=0A= t=3Dz.substring(0,i);=0A= if ((i=3Dt.lastIndexOf(".")) > -1) {=0A= t=3Dt.substring(i+1,t.length);=0A= cn=3D(t*1);=0A= }=0A= }=0A= if (cs=3D=3D0 || _ufns=3D=3D1) {=0A= t=3D_uGC(dc,"__utma=3D"+_udh,";");=0A= if ((i=3Dt.lastIndexOf(".")) > 9) {=0A= _uns=3Dt.substring(i+1,t.length);=0A= _uns=3D(_uns*1);=0A= }=0A= cn++;=0A= if (_uns=3D=3D0) _uns=3D1;=0A= _ubd.cookie=3D"__utmz=3D"+_udh+"."+_ust+"."+_uns+"."+cn+"."+c+"; = path=3D"+_utcp+"; "+x+_udo;=0A= }=0A= if (cs=3D=3D0 || _ufns=3D=3D1) return "&utmcn=3D1";=0A= else return "&utmcr=3D1";=0A= }=0A= function _uRef() {=0A= if (_ur=3D=3D"0" || _ur=3D=3D"" || _ur=3D=3D"-") return "";=0A= var i=3D0,h,k,n;=0A= if ((i=3D_ur.indexOf("://"))<0) return "";=0A= h=3D_ur.substring(i+3,_ur.length);=0A= if (h.indexOf("/") > -1) {=0A= k=3Dh.substring(h.indexOf("/"),h.length);=0A= if (k.indexOf("?") > -1) k=3Dk.substring(0,k.indexOf("?"));=0A= h=3Dh.substring(0,h.indexOf("/"));=0A= }=0A= h=3Dh.toLowerCase();=0A= n=3Dh;=0A= if ((i=3Dn.indexOf(":")) > -1) n=3Dn.substring(0,i);=0A= for (var ii=3D0;ii<_uRno.length;ii++) {=0A= if ((i=3Dn.indexOf(_uRno[ii].toLowerCase())) > -1 && = n.length=3D=3D(i+_uRno[ii].length)) { _ufno=3D1; break; }=0A= }=0A= if (h.indexOf("www.")=3D=3D0) h=3Dh.substring(4,h.length);=0A= return = "utmccn=3D(referral)|utmcsr=3D"+_uEC(h)+"|"+"utmcct=3D"+_uEC(k)+"|utmcmd=3D= referral";=0A= }=0A= function _uOrg(t) {=0A= if (_ur=3D=3D"0" || _ur=3D=3D"" || _ur=3D=3D"-") return "";=0A= var i=3D0,h,k;=0A= if ((i=3D_ur.indexOf("://")) < 0) return "";=0A= h=3D_ur.substring(i+3,_ur.length);=0A= if (h.indexOf("/") > -1) {=0A= h=3Dh.substring(0,h.indexOf("/"));=0A= }=0A= for (var ii=3D0;ii<_uOsr.length;ii++) {=0A= if (h.toLowerCase().indexOf(_uOsr[ii].toLowerCase()) > -1) {=0A= if ((i=3D_ur.indexOf("?"+_uOkw[ii]+"=3D")) > -1 || = (i=3D_ur.indexOf("&"+_uOkw[ii]+"=3D")) > -1) {=0A= k=3D_ur.substring(i+_uOkw[ii].length+2,_ur.length);=0A= if ((i=3Dk.indexOf("&")) > -1) k=3Dk.substring(0,i);=0A= for (var yy=3D0;yy<_uOno.length;yy++) {=0A= if (_uOno[yy].toLowerCase()=3D=3Dk.toLowerCase()) { _ufno=3D1; = break; }=0A= }=0A= if (t) return _uEC(k);=0A= else return = "utmccn=3D(organic)|utmcsr=3D"+_uEC(_uOsr[ii])+"|"+"utmctr=3D"+_uEC(k)+"|= utmcmd=3Dorganic";=0A= }=0A= }=0A= }=0A= return "";=0A= }=0A= function _uBInfo() {=0A= var sr=3D"-",sc=3D"-",ul=3D"-",fl=3D"-",cs=3D"-",je=3D1;=0A= var n=3Dnavigator;=0A= if (self.screen) {=0A= sr=3Dscreen.width+"x"+screen.height;=0A= sc=3Dscreen.colorDepth+"-bit";=0A= } else if (self.java) {=0A= var j=3Djava.awt.Toolkit.getDefaultToolkit();=0A= var s=3Dj.getScreenSize();=0A= sr=3Ds.width+"x"+s.height;=0A= }=0A= if (n.language) { ul=3Dn.language.toLowerCase(); }=0A= else if (n.browserLanguage) { ul=3Dn.browserLanguage.toLowerCase(); }=0A= je=3Dn.javaEnabled()?1:0;=0A= if (_uflash) fl=3D_uFlash();=0A= if (_ubd.characterSet) cs=3D_uES(_ubd.characterSet);=0A= else if (_ubd.charset) cs=3D_uES(_ubd.charset);=0A= return = "&utmcs=3D"+cs+"&utmsr=3D"+sr+"&utmsc=3D"+sc+"&utmul=3D"+ul+"&utmje=3D"+j= e+"&utmfl=3D"+fl;=0A= }=0A= function __utmSetTrans() {=0A= var e;=0A= if (_ubd.getElementById) e=3D_ubd.getElementById("utmtrans");=0A= else if (_ubd.utmform && _ubd.utmform.utmtrans) = e=3D_ubd.utmform.utmtrans;=0A= if (!e) return;=0A= var l=3De.value.split("UTM:");=0A= var i,i2,c;=0A= if (_userv=3D=3D0 || _userv=3D=3D2) i=3Dnew Array();=0A= if (_userv=3D=3D1 || _userv=3D=3D2) { i2=3Dnew Array(); c=3D_uGCS(); }=0A= =0A= for (var ii=3D0;ii=3D2;ii--) {=0A= try {=0A= var fl=3Deval("new = ActiveXObject('ShockwaveFlash.ShockwaveFlash."+ii+"');");=0A= if (fl) { f=3Dii + '.0'; break; }=0A= }=0A= catch(e) {}=0A= }=0A= }=0A= return f;=0A= }=0A= function __utmLinker(l,h) {=0A= if (!_ulink) return;=0A= var p,k,a=3D"-",b=3D"-",c=3D"-",x=3D"-",z=3D"-",v=3D"-";=0A= var dc=3D_ubd.cookie;=0A= if (!l || l=3D=3D"") return;=0A= var iq =3D l.indexOf("?"); =0A= var ih =3D l.indexOf("#"); =0A= if (dc) {=0A= a=3D_uES(_uGC(dc,"__utma=3D"+_udh,";"));=0A= b=3D_uES(_uGC(dc,"__utmb=3D"+_udh,";"));=0A= c=3D_uES(_uGC(dc,"__utmc=3D"+_udh,";"));=0A= x=3D_uES(_uGC(dc,"__utmx=3D"+_udh,";"));=0A= z=3D_uES(_uGC(dc,"__utmz=3D"+_udh,";"));=0A= v=3D_uES(_uGC(dc,"__utmv=3D"+_udh,";"));=0A= k=3D(_uHash(a+b+c+x+z+v)*1)+(_udh*1);=0A= = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmx=3D"+x+"&__utmz=3D= "+z+"&__utmv=3D"+v+"&__utmk=3D"+k;=0A= }=0A= if (p) {=0A= if (h && ih>-1) return;=0A= if (h) { _udl.href=3Dl+"#"+p; }=0A= else {=0A= if (iq=3D=3D-1 && ih=3D=3D-1) _udl.href=3Dl+"?"+p;=0A= else if (ih=3D=3D-1) _udl.href=3Dl+"&"+p;=0A= else if (iq=3D=3D-1) = _udl.href=3Dl.substring(0,ih-1)+"?"+p+l.substring(ih);=0A= else _udl.href=3Dl.substring(0,ih-1)+"&"+p+l.substring(ih);=0A= }=0A= } else { _udl.href=3Dl; }=0A= }=0A= function __utmLinkPost(f,h) {=0A= if (!_ulink) return;=0A= var p,k,a=3D"-",b=3D"-",c=3D"-",x=3D"-",z=3D"-",v=3D"-";=0A= var dc=3D_ubd.cookie;=0A= if (!f || !f.action) return;=0A= var iq =3D f.action.indexOf("?"); =0A= var ih =3D f.action.indexOf("#"); =0A= if (dc) {=0A= a=3D_uES(_uGC(dc,"__utma=3D"+_udh,";"));=0A= b=3D_uES(_uGC(dc,"__utmb=3D"+_udh,";"));=0A= c=3D_uES(_uGC(dc,"__utmc=3D"+_udh,";"));=0A= x=3D_uES(_uGC(dc,"__utmx=3D"+_udh,";"));=0A= z=3D_uES(_uGC(dc,"__utmz=3D"+_udh,";"));=0A= v=3D_uES(_uGC(dc,"__utmv=3D"+_udh,";"));=0A= k=3D(_uHash(a+b+c+x+z+v)*1)+(_udh*1);=0A= = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmx=3D"+x+"&__utmz=3D= "+z+"&__utmv=3D"+v+"&__utmk=3D"+k;=0A= }=0A= if (p) {=0A= if (h && ih>-1) return;=0A= if (h) { f.action+=3D"#"+p; }=0A= else {=0A= if (iq=3D=3D-1 && ih=3D=3D-1) f.action+=3D"?"+p;=0A= else if (ih=3D=3D-1) f.action+=3D"&"+p;=0A= else if (iq=3D=3D-1) = f.action=3Df.action.substring(0,ih-1)+"?"+p+f.action.substring(ih);=0A= else = f.action=3Df.action.substring(0,ih-1)+"&"+p+f.action.substring(ih);=0A= }=0A= }=0A= return;=0A= }=0A= function __utmSetVar(v) {=0A= if (!v || v=3D=3D"") return;=0A= if (!_udo || _udo =3D=3D "") {=0A= _udh=3D_uDomain();=0A= if (_udn && _udn!=3D"") { _udo=3D" domain=3D"+_udn+";"; }=0A= }=0A= if (!_uVG()) return;=0A= var r=3DMath.round(Math.random() * 2147483647);=0A= _ubd.cookie=3D"__utmv=3D"+_udh+"."+_uES(v)+"; path=3D"+_utcp+"; = expires=3D"+_uNx()+";"+_udo;=0A= var s=3D"&utmt=3Dvar&utmn=3D"+r;=0A= if ((_userv=3D=3D0 || _userv=3D=3D2) && _uSP()) {=0A= var i=3Dnew Image(1,1);=0A= i.src=3D_ugifpath+"?"+"utmwv=3D"+_uwv+s;=0A= i.onload=3Dfunction() { _uVoid(); }=0A= }=0A= if ((_userv=3D=3D1 || _userv=3D=3D2) && _uSP()) {=0A= var i2=3Dnew Image(1,1);=0A= = i2.src=3D_ugifpath2+"?"+"utmwv=3D"+_uwv+s+"&utmac=3D"+_uacct+"&utmcc=3D"+= _uGCS();=0A= i2.onload=3Dfunction() { _uVoid(); }=0A= }=0A= }=0A= function _uGCS() {=0A= var t,c=3D"",dc=3D_ubd.cookie;=0A= if ((t=3D_uGC(dc,"__utma=3D"+_udh,";"))!=3D"-") = c+=3D_uES("__utma=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmb=3D"+_udh,";"))!=3D"-") = c+=3D_uES("__utmb=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmc=3D"+_udh,";"))!=3D"-") = c+=3D_uES("__utmc=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmx=3D"+_udh,";"))!=3D"-") = c+=3D_uES("__utmx=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmz=3D"+_udh,";"))!=3D"-") = c+=3D_uES("__utmz=3D"+t+";+");=0A= if ((t=3D_uGC(dc,"__utmv=3D"+_udh,";"))!=3D"-") = c+=3D_uES("__utmv=3D"+t+";");=0A= if (c.charAt(c.length-1)=3D=3D"+") c=3Dc.substring(0,c.length-1);=0A= return c;=0A= }=0A= function _uGC(l,n,s) {=0A= if (!l || l=3D=3D"" || !n || n=3D=3D"" || !s || s=3D=3D"") return "-";=0A= var i,i2,i3,c=3D"-";=0A= i=3Dl.indexOf(n);=0A= i3=3Dn.indexOf("=3D")+1;=0A= if (i > -1) {=0A= i2=3Dl.indexOf(s,i); if (i2 < 0) { i2=3Dl.length; }=0A= c=3Dl.substring((i+i3),i2);=0A= }=0A= return c;=0A= }=0A= function _uDomain() {=0A= if (!_udn || _udn=3D=3D"" || _udn=3D=3D"none") { _udn=3D""; return 1; }=0A= if (_udn=3D=3D"auto") {=0A= var d=3D_ubd.domain;=0A= if (d.substring(0,4)=3D=3D"www.") {=0A= d=3Dd.substring(4,d.length);=0A= }=0A= _udn=3Dd;=0A= }=0A= _udn =3D _udn.toLowerCase(); =0A= if (_uhash=3D=3D"off") return 1;=0A= return _uHash(_udn);=0A= }=0A= function _uHash(d) {=0A= if (!d || d=3D=3D"") return 1;=0A= var h=3D0,g=3D0;=0A= for (var i=3Dd.length-1;i>=3D0;i--) {=0A= var c=3DparseInt(d.charCodeAt(i));=0A= h=3D((h << 6) & 0xfffffff) + c + (c << 14);=0A= if ((g=3Dh & 0xfe00000)!=3D0) h=3D(h ^ (g >> 21));=0A= }=0A= return h;=0A= }=0A= function _uFixA(c,s,t) {=0A= if (!c || c=3D=3D"" || !s || s=3D=3D"" || !t || t=3D=3D"") return "-";=0A= var a=3D_uGC(c,"__utma=3D"+_udh,s);=0A= var lt=3D0,i=3D0;=0A= if ((i=3Da.lastIndexOf(".")) > 9) {=0A= _uns=3Da.substring(i+1,a.length);=0A= _uns=3D(_uns*1)+1;=0A= a=3Da.substring(0,i);=0A= if ((i=3Da.lastIndexOf(".")) > 7) {=0A= lt=3Da.substring(i+1,a.length);=0A= a=3Da.substring(0,i);=0A= }=0A= if ((i=3Da.lastIndexOf(".")) > 5) {=0A= a=3Da.substring(0,i);=0A= }=0A= a+=3D"."+lt+"."+t+"."+_uns;=0A= }=0A= return a;=0A= }=0A= function _uTrim(s) {=0A= if (!s || s=3D=3D"") return "";=0A= while ((s.charAt(0)=3D=3D' ') || (s.charAt(0)=3D=3D'\n') || = (s.charAt(0,1)=3D=3D'\r')) s=3Ds.substring(1,s.length);=0A= while ((s.charAt(s.length-1)=3D=3D' ') || = (s.charAt(s.length-1)=3D=3D'\n') || (s.charAt(s.length-1)=3D=3D'\r')) = s=3Ds.substring(0,s.length-1);=0A= return s;=0A= }=0A= function _uEC(s) {=0A= var n=3D"";=0A= if (!s || s=3D=3D"") return "";=0A= for (var i=3D0;i0) r=3Da.substring(i+1,i2); else return = ""; =0A= if ((i=3Da.indexOf(".",i2+1))>0) t=3Da.substring(i2+1,i); else return = ""; =0A= if (f) {=0A= return r;=0A= } else {=0A= var c=3Dnew = Array('A','B','C','D','E','F','G','H','J','K','L','M','N','P','R','S','T'= ,'U','V','W','X','Y','Z','1','2','3','4','5','6','7','8','9');=0A= return = c[r>>28&m]+c[r>>23&m]+c[r>>18&m]+c[r>>13&m]+"-"+c[r>>8&m]+c[r>>3&m]+c[((r= &7)<<2)+(t>>30&3)]+c[t>>25&m]+c[t>>20&m]+"-"+c[t>>15&m]+c[t>>10&m]+c[t>>5= &m]+c[t&m];=0A= }=0A= }=0A= function _uIN(n) {=0A= if (!n) return false;=0A= for (var i=3D0;i"9") && (c!=3D".")) return false;=0A= }=0A= return true;=0A= }=0A= function _uES(s,u) {=0A= if (typeof(encodeURIComponent) =3D=3D 'function') {=0A= if (u) return encodeURI(s);=0A= else return encodeURIComponent(s);=0A= } else {=0A= return escape(s);=0A= }=0A= }=0A= function _uUES(s) {=0A= if (typeof(decodeURIComponent) =3D=3D 'function') {=0A= return decodeURIComponent(s);=0A= } else {=0A= return unescape(s);=0A= }=0A= }=0A= function _uVG() {=0A= if((_udn.indexOf("www.google.") =3D=3D 0 || _udn.indexOf(".google.") = =3D=3D 0 || _udn.indexOf("google.") =3D=3D 0) && _utcp=3D=3D'/' && = _udn.indexOf("google.org")=3D=3D-1) {=0A= return false;=0A= }=0A= return true;=0A= }=0A= function _uSP() {=0A= var s=3D100;=0A= if (_usample) s=3D_usample;=0A= if(s>=3D100 || s<=3D0) return true;=0A= return ((__utmVisitorCode(1)%10000)<(s*100));=0A= }=0A= function urchinPathCopy(p){=0A= var d=3Ddocument,nx,tx,sx,i,c,cs,t,h,o;=0A= cs=3Dnew Array("a","b","c","v","x","z");=0A= h=3D_uDomain(); if (_udn && _udn!=3D"") o=3D" domain=3D"+_udn+";";=0A= nx=3D_uNx()+";";=0A= tx=3Dnew Date(); tx.setTime(tx.getTime()+(_utimeout*1000));=0A= tx=3Dtx.toGMTString()+";";=0A= sx=3Dnew Date(); sx.setTime(sx.getTime()+(_ucto*1000));=0A= sx=3Dsx.toGMTString()+";";=0A= for (i=3D0;i<6;i++){=0A= t=3D" expires=3D";=0A= if (i=3D=3D1) t+=3Dtx; else if (i=3D=3D2) t=3D""; else if (i=3D=3D5) = t+=3Dsx; else t+=3Dnx;=0A= c=3D_uGC(d.cookie,"__utm"+cs[i]+"=3D"+h,";");=0A= if (c!=3D"-") d.cookie=3D"__utm"+cs[i]+"=3D"+c+"; path=3D"+p+";"+t+o;=0A= }=0A= }=0A= function _uCO() {=0A= if (!_utk || _utk=3D=3D"" || _utk.length<10) return;=0A= var d=3D'www.google.com';=0A= if (_utk.charAt(0)=3D=3D'!') d=3D'analytics.corp.google.com';=0A= _ubd.cookie=3D"GASO=3D"+_utk+"; path=3D"+_utcp+";"+_udo;=0A= var sc=3Ddocument.createElement('script');=0A= sc.type=3D'text/javascript';=0A= sc.id=3D"_gasojs";=0A= = sc.src=3D'https://'+d+'/analytics/reporting/overlay_js?gaso=3D'+_utk+'&'+= Math.random();=0A= document.getElementsByTagName('head')[0].appendChild(sc); =0A= }=0A= function _uGT() {=0A= var h=3Dlocation.hash, a;=0A= if (h && h!=3D"" && h.indexOf("#gaso=3D")=3D=3D0) {=0A= a=3D_uGC(h,"gaso=3D","&");=0A= } else {=0A= a=3D_uGC(_ubd.cookie,"GASO=3D",";");=0A= }=0A= return a;=0A= }=0A= var _utk=3D_uGT();=0A= if (_utk && _utk!=3D"" && _utk.length>10) {=0A= if (window.addEventListener) {=0A= window.addEventListener('load', _uCO, false); =0A= } else if (window.attachEvent) { =0A= window.attachEvent('onload', _uCO);=0A= }=0A= }=0A= =0A= function _uNx() {=0A= return (new Date((new Date()).getTime()+63072000000)).toGMTString();=0A= }=0A= ------=_NextPart_000_002F_01C8636A.6351FD60--