Glioblastoma Subclasses = Can Be Defined by Activity among Signal Transduction Pathways and = Associated Genomic Alterations

Results

Specimens and protein = analysis

27 glioma surgical = samples were=20 identified from a database of patients operated on at MSKCC and = consented=20 to the IRB-approved protocol. Clinical and pathologic = characteristics are=20 summarized in Table 1. Pathology = included=20 20 GBM, 2 anaplastic astrocytomas, 4 oligodendrogliomas of which 2 = were=20 anaplastic tumors, and one tumor characterized as high grade = glioma with=20 glioneuronal elements. 11 GBM were recurrent after treatment (RT = +/=E2=88=92=20 temozolomide) and two of these were secondary GBM. The age range = was from=20 32 to 74 (median 53).

Protein extracts from = these tumors=20 were analyzed by western blot for the activity of various = signaling=20 pathways related to glioma formation or stem cell character, = totaling 55=20 antibodies for proteins in total and active forms (Table S1). Antibodies were selected = based on=20 known performance. Briefly, PDGF pathway activity was measured by = PDGF=20 ligand (PDGFB), PDGFR=CE=B1, PDGFR=CE=B2 and phospho-PDGFR=CE=B2. = EGFR activity was=20 assessed by antibodies specific for EGFR and phospho-EGFR. The = downstream=20 pathways interrogated included Ras, Akt, Notch, Wnt and SHH. The = Akt=20 pathway was interrogated by PTEN, total AKT, phospho-AKT and RHEB. = Activation of mTOR was measured by phospho-S6 ribosomal protein = (p-S6RP).=20 The Ras pathway was interrogated by BRAF and total/phospho-MEK and = ERK.=20 Notch pathway activity was measured by the Notch ligands Delta = (DLL1) and=20 Jagged (JAG1), full length Notch receptors 1 and 2, cleaved Notch = 1 and 2=20 and downstream Notch target HES1. The Wnt pathway was assessed by = beta=20 catenin levels and the SHH pathway by SHH levels. NF1 was assayed = in=20 preserved lysates at a later date, after mutations were reported = for this=20 gene in GBM.[7], [8] Quantified bands for 55 = antibodies=20 were normalized against actin or tubulin. HEB, Notch1 and Notch2=20 antibodies each generated two bands which were independently = quantified.=20 Therefore a total of 58 protein forms were quantified and = normalized.=20 Relevant western bands selected by size are summarized in Figure S1A, S1B, S1C, S1D, and = quantified=20 values normalized against actin are given in Table S2A, S2B, S2C.

Principal Component Analysis = and=20 unsupervised clustering identify three patterns of signaling in = GBM

As expected, overall = activation of=20 signal transduction pathways differed markedly between the glioma = samples=20 and the normal brain reference. While some pathways such as PI3K = and MAPK=20 were active nearly uniformly among gliomas, we sought to = investigate=20 whether relative differences might distinguish subclasses among = the=20 samples with GBM pathology. The overall pattern of protein = expression and=20 activation was first assessed by Principal Component Analysis = (PCA).=20 Quantified western data for 57 protein forms were standardized = across the=20 set of GBM samples for analysis (n 3D"

=3D

20). We excluded p53 from analysis because common = inactivating=20 mutations can be associated with increased or decreased protein = levels.=20 For clarity in the figure, NF1 was represented as =E2=80=9CNF1 = loss=E2=80=9D (zero minus=20 standardized expression), reflecting the role of NF1 as an = inhibitor of=20 RAS signaling. The first two PCA components together accounted for = the=20 majority of variation in protein levels (Figure S2). A cloud plot showing the = first two=20 principal components is shown in Figure 1A

=20 and revealed three patterns of total and activated protein levels. = One=20 component (PC2) distinguished proteins which were correlated with = EGFR=20 total protein versus those correlated with PDGFB levels. The other = component (PC1) distinguished a third group of proteins = anti-correlated=20 with EGFR and PDGFB. Elevated levels of these proteins were = associated=20 with low levels of Neurofibromin 1 protein (=E2=80=9CNF1 = loss=E2=80=9D in Figure 1A

<= /DIV>

Table=20 1

Patient = and tumor=20 characteristics.

In order to evaluate the = significance=20 of this three-way classification, we performed unsupervised = k-means=20 analysis on the same standardized data from the 20 GBM samples and = evaluated the fit and stability over a range of cluster sizes. = K-means for=20 cluster sizes from 2=E2=80=938 was run for 10,000 iterations, = leaving out 15% of=20 the data with each iteration (i.e. three randomly chosen samples = left=20 out). Consensus matrices were evaluated for cluster assignment = stability=20 both visually and by cophenetic correlation (see Figure S3A). As predicted from PCA, = the=20 correlation of protein levels was well-described by 3-way = clustering (Figure 1B

).=20 Considering only those proteins which co-cluster in >95% of = k-means=20 iterations, three =E2=80=9Ccore=E2=80=9D protein groups were = identified. These protein=20 groups were named according to the strong separation by PCA of = EGFR, PDGF=20 and NF1 levels, with consideration that alterations in these three = genes=20 are common in glioblastoma and each is pathogenic in=20 genetically-engineered mouse glioma models:

EGFR = core

This cluster of 15 = proteins=20 features high levels of total and phospho-EGFR. Prominent Notch = activity=20 is represented in this group by high levels of the active cleaved = form of=20 Notch 1 (Notch 1 ICD) as well as of ligands Jagged (JAG1) and = Delta-like 1=20 (DLL1) and of the downstream Notch transcriptional target HES1. = Wnt=20 signaling is suggested by increased (stabilized) B-catenin levels. = Other=20 proteins relatively increased in this core group are EIF4EBP1, = EIF4E,=20 RHEB, phospho-BAD, INI1, La/SSB, FGF2, and phospho-Rb1. There was = a trend=20 for higher phospho-Akt levels, though this did not reach = significance=20 (p 3D"

=3D

0.08).

PDGF = core

This cluster is = comprised of 17=20 proteins including PDGFB, phospho-PDGFR=CE=B2 and phospho-NFKB1. = PTEN levels=20 are higher in this group and relatively increased Ras activity is=20 evidenced by elevated total and phosphorylated MEK and ERK. Levels = of MTOR=20 and downstream targets S6K and p-S6K were better-correlated with = the PDGF=20 core than the EGFR core, though levels were high in tumors of both = classes. Other PDGF-associated proteins were SHH, HEB 1/2 (TCF12,=20 associated with oligodendrocyte development), BRAF, p-FOXO1 and=20 TSC1.

NF1 Core=20

This group is = defined by higher=20 levels of 5 proteins: IRS1, IGFBP5, YKL40 and VEGF. As suggested = by PCA=20 analysis, the group is also strongly associated with low levels of = NF1=20 (plotted as the inverse protein level, =E2=80=9CNF1 = loss=E2=80=9D). Sporadic elevation of=20 MYC, NMYC, and KRAS-GTP was also seen in this group. Compared to = the other=20 classes, GBM samples showing NF1-core expression pattern showed = relatively=20 suppressed levels of total- and phospho-proteins in the PI3K and = MAPK=20 pathways. These differences were relative, however, and evaluation = of the=20 Western bands shows that high levels of phosphorylation were = common in=20 nearly all tumors (see Figure S1).

Identification of proteomic = tumor classes=20 by signaling pattern

The 44 core proteins = identified in=20 the previous analysis were then used to cluster the larger set of = 27=20 glioma samples. K-means clustering of samples was performed as = before,=20 leaving out 15% of proteins (7 out of 44) with each of 10,000 = iterations.=20 As expected in this supervised approach, three-way clustering was = the best=20 fit and all but three glioma samples showed stable clustering into = signaling classes associated with EGFR, PDGF and NF1-loss (Figure S3B). Figure 2

=20 summarizes how tumors are clustered by core signature proteins, = and how=20 these groups relate to tumor histopathology and genotype derived = from aCGH=20 profiling and resequencing of EGFR.

Figure=20 1

Analysis = of=20 quantified western data in 20 GBM identifies three signaling = axes=20 associated with EGFR overexpression, PDGFB overexpression, = and loss=20 of NF1.

Tumors with GBM histopathology = were evenly=20 distributed among the three core groups, six in each group. The = only known=20 secondary GBM clustered with the NF1-loss group. Two anaplastic=20 astrocytomas (AA23 and AA.26) were found to cluster disparately = with the=20 PDGF and NF1 groups, respectively. Two of the four = oligodendrogliomas=20 clustered with the PDGF group: one low-grade (ODG.25) and one = anaplastic=20 (AO.24). Interestingly, one of the two low-grade = oligodendrogliomas=20 clustered with the EGFR group (ODG.22) and did in fact harbor = high-level=20 EGFR amplification. One anaplastic oligodendroglioma (AO.21) = showed no=20 distinct proteomic pattern and remained unclassified. There was a = trend=20 for untreated tumors in the EGFR tumor group (6 untreated vs. 1 = treated)=20 and for treated tumors in the PDGF group (3 untreated, 6 treated) = but this=20 was neither significant for GBM (p 3D"

=3D

0.11) nor for all tumors (p 3D"

=3D

0.09). Testing protein levels individually between = treated and=20 untreated GBM, PDGFB was the most significantly different and was = higher=20 in treated GBM (p 3D"

=3D

0.009) and in treated tumors overall (p 3D"

=3D

0.028) although neither was significant after = correction for=20 multiple testing.

24 of the 27 tumors for = which=20 sufficient tissue was available were analyzed by array-CGH = (Agilent Whole=20 Genome 244K) and resequencing of EGFR, PTEN and TP53. Array-CGH = profiles=20 were analyzed for copy number aberrations commonly described in = GBM: focal=20 amplification of EGFR, MET and PDGFRA; = gain of=20 chr7 without focal amplification; loss of chr10 or 10q23 region = spanning=20 PTEN; loss and/or homozygous deletion of 9p21 including=20 Ink4a/ARF.[1], [23], [24] Figure 2

=20 summarizes the finding of focal amplification of MET and=20 EGFR, gain of chromosome 7, homozygous deletion spanning = the=20 Ink4a/ARF locus, and loss at PTEN locus. Complete ACGH = profiles=20 are depicted in Figure S4.

EGFR = proteomic tumor=20 class

Six of the seven = tumors in this=20 class showed EGFR-region amplification and four showed = point=20 mutations in the extracellular domain (ECD) previously described = in GBM as=20 activating mutations: A289V (GBM.10 and GBM.6), T263P (GBM.8), = G598V=20 (GBM.1) and R108K (GBM.6).[25] The only tumor in the EGFR = signaling=20 cluster that did not show focal EGFR amplification was = found to=20 harbor amplification of a narrow region including MET. = Neither=20 overexpression nor significant phosphorylation of EGFR protein was = seen in=20 this case. All tumors in the EGFR proteomic tumor class had = deletion of=20 the Ink4a/ARF locus compared with only 3/17 (18%) in the = other=20 groups. All had loss of ch10 and mutation of PTEN in the remaining = allele=20 was observed in one case.

PDGF = proteomic tumor=20 class

Although this group = of tumors=20 is defined by evidence of PDGF signaling at the protein level, = none of the=20 9 tumors in this class showed gene amplification of either PDGF = receptors=20 or ligands. One tumor had both Ink4a/ARF region deletion = and=20 EGFR amplification, however total and phosphorylated EGFR = levels=20 in this tumor were low and PDGFB was present. Of note, a second = tumor with=20 focal MET amplification, GBM.18, was classified here and = showed=20 extremely high levels of PDGFB and associated = signaling.

NF1=20 proteomic tumor class

Tumors in this = class included=20 six GBM, one of which was a secondary GBM, one anaplastic = astrocytoma, and=20 one tumor with histopathologic features of GBM and synaptophysin=20 positivity (=E2=80=9Cglioneuronal tumor=E2=80=9D, GNT.15). The = NF1-associated class is=20 distinguished by chr7 gain without focal amplification of either=20 EGFR or the MET receptor which is significantly = more=20 frequent in this class (5/7, 71%) compared to the others (2/14, = 14%, p=3D 3D"

0.017, Fisher's Exact test).

Integrated analysis of = molecularly=20 defined subclasses of GBM from The Cancer Genome Atlas identifies = distinct=20 tumor subclasses enriched for mutations in EGFR, = PDGFRA,=20 and NF1

Glioblastoma datasets = from The=20 Cancer Genome Atlas were analyzed for alterations in = EGFR,=20 PDGFRA and NF1 and the possible association of = mutations=20 in these genes with transcriptomally-defined subclasses. Of 278 = tumors for=20 which chromosomal copy number and/or mutation data were available, = amplification and/or somatic non-synonymous mutation of = EGFR was=20 found in 40% (n 3D"

=3D

111) and of PDGFRA in 7% (n 3D"

=3D

19), while chromosomal loss and/or mutation of = NF1 was=20 found in 16% (n 3D"

=3D

45). As shown in Figure 3

,=20 genomic alterations in these three genes are largely mutually = exclusive,=20 suggesting distinct tumor subclasses among this portion of GBM = samples for=20 which clear genomic alterations could be detected.

Figure=20 2

K-means = clustering=20 of gliomas by signature-defining proteins.

We next sought to determine if = these=20 subclasses might be associated with distinct transcriptomal = signatures.=20 Using normalized gene expression profiles on 243 tumors downloaded = from=20 The Cancer Genome Atlas public portal, we applied unsupervised=20 hierarchical clustering which identified 4 main cluster branches = (Figure 4

).=20 This grouping was concordant with comparable 4-way cluster = structure=20 recently reported by the TCGA.[26] Integration of copy number=20 aberration, mutation and expression of EGFR, = PDGFRA and=20 NF1 revealed that three of the transcriptomal classes = were=20 enriched for alterations in each gene, respectively, although the=20 segregation was imperfect. We named these three subclasses = =E2=80=9CEGFR=20 cocluster=E2=80=9D, =E2=80=9CPDGFRA cocluster=E2=80=9D and = =E2=80=9CNF1 cocluster=E2=80=9D based on the=20 predominant signal transduction pathway member enriched for = mutation in=20 each group. A fourth transcriptomal class had neither significant=20 enrichment for mutations in either of EGFR, = PDGFRA or=20 NF1, nor enrichment for mutations in any other sequenced = gene in=20 the TCGA dataset. As shown in Figure 4

=20 as described below, PDGFRA amplification was only present = in the=20 minority of PDGFRA-cocluster tumors and this transcriptomal class = included=20 a subset of tumors with EGFR or Met amplifications. The = PDGFRA-cocluster=20 showed high expression of GRIA2, OLIG2, and=20 NCAM1/2 as well as other genes which are signatures of = the=20 =E2=80=9CProneural=E2=80=9D transcriptomal class of GBM previously = described.[19] Conversely, signature = genes of the=20 =E2=80=9CMesenchymal=E2=80=9D GBM class such as = YKL40/CHI3L1, IGFBP2 and=20 VEGFA were most highly expressed in the NF1-cocluster=20 transcriptomal group (Figure S5). The EGFR-cocluster class = showed=20 intermediate expression levels of Proneural and Mesenchymal = signature=20 genes.

Figure=20 3

Integration of=20 mutation and chromosomal copy number data from TCGA reveals=20 aberrations of EGFR to be mutually exclusive of aberrations = in=20 PDGFRA and NF1.

Unsupervised clustering = reflects the=20 combined effect of multiple confounding influences on the = transcriptome,=20 including presence of necrosis, inflammatory cells, inclusion of = brain=20 parenchyma, etc. In order to clarify the specific relationship of=20 EGFR, PDGFRA and NF1 mutations to the=20 transcriptome in GBM, we derived distinct expression signatures = associated=20 with mutation/aberration of these genes among the set of 147 = tumors for=20 which mutation/aberration was found in one and only one of the = three.=20 Together, 1,943 genes were identified which distinguished the = three=20 mutation classes (see Methods). Hierarchical clustering performed with = this gene=20 set on the full set of 243 GBM profiles resulted in clear division = of GBM=20 into just 3 subclasses, each enriched for the associated = alteration of=20 EGFR, PDGFRA and NF1 (Figure S6).

Comparison of proteomic and=20 transcriptomal subclasses

We investigated possible = correspondence between the proteomic EGFR, PDGF and NF1 classes = and the=20 transcriptomal EGFR-, PDGFRA-, and NF1-coclusters derived from = TCGA data=20 by comparing signature genomic aberrations. As shown in Figure 4

,=20 integration of mutation and copy number data confirmed the strong=20 association of EGFR amplification and mutation in tumors = from the=20 EGFR-cocluster (59/79, 75%) significantly more than in the other = two=20 classes (21/99, 21.2%, p

=3D

7.8e=E2=88=9213). This subset of samples also harbored = frequent=20 homozygous deletion of 9p21 spanning the Ink4a/ARF locus = (75% vs=20 35%, p

=3D

2.0e=E2=88=927). These findings were concordant with = genomic profiling of=20 tumors the EGFR signaling class. Conversely, chr7 gain without = focal=20 amplification of either EGFR or MET was most = common in=20 the NF1 transcriptomal cocluster (60.7% vs 23%, p

=3D

1.6e=E2=88=926), and this was concordant with aCGH = profiling of tumors in=20 the NF1 signaling class.

Among TCGA samples, amplifications = of=20 PDGFRA were more commonly seen in the PDGFRA = transcriptomal=20 cocluster (25.6% vs 1.5% in other classes; p 3D"

=3D

2.9e=E2=88=926) as were PDGFRA mutations = (3/29 3D"

=3D

10.3% vs 0/79, p 3D"

=3D

0.049). However 4 out of 5 MET-amplified = tumors were in=20 this class and 7 tumors showed focal amplification of = EGFR.=20 Therefore there was no single copy number aberration = distinguishing this=20 class. There were no cases of PDGFRA amplification among = the 24=20 tumors in our study for which aCGH was performed. Among the 9 = tumors in=20 our PDGF signaling class, one had MET amplification and = one had=20 EGFR amplification. Despite the absence of=20 PDGFRA-amplified cases in our sample set, the overall=20 distribution of EGFR, PDGFRA and MET=20 amplifications was found to be within the normal sampling error if = one=20 derives expectation frequencies from the TCGA data.

Comparison of genomic aberrations = suggested a=20 correspondence between proteomic classes of EGFR, NF1 and PDGF and = the=20 corresponding TCGA transcriptomal classes, therefore expression = levels for=20 genes encoding the core proteins (total forms) were next assessed = in each=20 of the four transcriptomal clusters. Among genes encoding = EGFR-core=20 proteins, the corresponding EGFR transcriptomal cocluster subclass = showed=20 significant overexpression of EGFR, JAG1, and=20 HES1 compared to the other subclasses (p<1e=E2=88=925 = for each gene).=20 However other EGFR core proteins and Notch pathway members showed = no=20 elevation of mRNA expression in the corresponding transcriptomal = class and=20 therefore direct correlation could not be established.

Within the transcriptomal = NF1-cocluster, the=20 only overexpressed genes encoding NF1 core proteins were = IRS1 and=20 YKL40/CHI3L1. As seen in Figure 4

,=20 NF1 mRNA was strongly underexpressed in the NF1-cocluster class = compared=20 to other classes (p 3D"

=3D

4.4e=E2=88=9215), making NF1 mRNA = underexpression among the=20 strongest signatures of the transcriptomal class.

Within the PDGFRA = transcriptomal=20 cocluster, TSC2 and HEB/TCF12 were the only = genes among=20 the PDGF core protein group significantly overexpressed = (p<1e=E2=88=924). The=20 PDGFRB gene was significantly underexpressed in = this=20 group, concordant with our observation that total protein levels = were=20 higher in the EGFR class even while the phosphorylated receptor = was=20 correlated with the PDGF class. Overexpression of PDGFRA = was a=20 prominent feature of the PDGFRA-cocluster tumors = (p<1e=E2=88=9212), nearly=20 always associated with gene amplification. Messenger RNA levels of = genes=20 encoding PDGF ligands were not elevated in the PDGFRA cocluster = even among=20 the subset of tumors showing PDGFRA amplification. We = further=20 investigated the relationship of PDGFB mRNA and protein levels in = a=20 validation set of 40 gliomas and found no correlation between mRNA = expression and levels of protein even though the latter were = highly=20 variable (Figure S7). This reflects the strong = regulation of PDGF at the level of translation rather than=20 transcription.[27], [28] It is likely that some = signaling proteins=20 in our study are closely coupled to mRNA levels while many others = are=20 regulated independently (or in negative feedback) with = corresponding=20 mRNA.

Discussion

Given the importance of = signaling in=20 the biology of gliomas, dividing these tumors into subsets by the = pattern=20 of coordinate signaling pathway activation may have practical = implications=20 for choice of therapies and for interpretation of patient = responses in=20 existing clinical trials. In order to clarify the net activation = of=20 signaling pathways we used a targeted proteomic analysis to = determine not=20 only the levels but the posttranslational modifications associated = with=20 signaling activity. The intrinsic cellular heterogeneity of = gliomas is=20 masked by the methods used in this study since both the proteomic = and TCGA=20 genomic analyses are performed on homogenized tissue, blending the = characteristics of the cells together. Additionally, the small = sample size=20 and selection of proteins in this study limits the statistical = power to=20 define protein correlations and sample assignments. Nonetheless, = we find=20 common features defining three basic groups by both genomic and = protein=20 analysis, illustrating the high complementarity between protein = signaling=20 activity, transcriptomal signature and genomic alteration in GBM. = The=20 observed enrichment of EGFR, PDGFRA and = NF=20 genomic alterations with transcriptome pattern could mean that = signaling=20 activity directly influences the transcriptome and/or that both = signaling=20 and the transcriptome patterns are part of a common underlying = phenotype.=20 Comparing unsupervised and supervised clustering results, it is = likely=20 that only a portion of the transcriptomal features distinguishing=20 unsupervised clusters are associated with signaling, either = directly or=20 indirectly. In fact, unsupervised clustering identifies four = clusters and=20 broader phenotypic and genetic differences distinguishing these = four=20 transcriptomal groups have been reported.[26]

Analysis of the downstream = signaling=20 components of the PDGF proteomic group revealed generally lower = PI3K/Akt=20 activity than in the EGFR glioma group although S6 phosphorylation = was=20 paradoxically high. Histologic analysis of the tumors provided an=20 explanation by demonstrating that strong pS6 immunopositivity was=20 localized in reactive astrocytes rather than tumor cells per se = (data not=20 shown), concordant with recent observations of mTOR activation in = reactive=20 astrocytes under experimental conditions of injury.[29] These cells were more = common in=20 PDGF-class tumors. We found a trend for treated tumors to be in = the PDGF=20 proteomic class and PDGFB levels were significantly higher in = treated=20 compared to untreated tumors. It is possible that some of the = features of=20 the PDGF signaling pattern are influenced by prior treatment = though it is=20 unlikely that this accounts for the genotypic differences in this=20 proteomic tumor class, such as the paucity of EGFR amplification, = chr7=20 gain and Ink4a/ARF locus deletion. Comparison with treated samples = in TCGA=20 is complicated by the fact that the current dataset contains few = treated=20 cases and of these, many are secondary GBM which would arguably be = assigned to the PDGFRA co-cluster by their common Proneural=20 signature.

The histology of the TCGA samples = was=20 uniformly GBM, but this is a histologically heterogeneous tumor = type. A=20 priori, it is possible that the transcriptomal classes identified = in this=20 analysis could be related to tumor sampling or microenvironment. = However,=20 this does not appear to be the case since well-defined genetic = lesions are=20 enriched in specific tumor classes and there is no evidence for = regional=20 localization of mutations in glioma as a general phenomenon. = Although=20 clinical and pathologic data are limited and a more detailed = review of=20 this information is underway, there appeared little clinical or=20 histological differences between the three groups identified in = this=20 analysis. PDGFRA-cocluster tumors in TCGA occurred in younger = patients,=20 and there were small but significant differences in the amount of=20 associated necrosis and inflammatory cells (data not shown).

It remains to be established = whether=20 ligand-driven PDGF signaling is common among tumors in the = transcriptomal=20 PDGFRA-cocluster and whether this is functionally important. We = have shown=20 that PDGFB ligand levels are highly variable in GBM, are = associated with=20 receptor activation, and are not correlated with mRNA expression. = The=20 PDGFRA-cocluster transcriptomal class shares features with the = Proneural=20 group of gliomas identified by Phillips et al using transcription=20 analysis, and is characterized by genes expressed during normal = cortical=20 oligodendrocyte development such as olig2, Sox2 and doublecortin = and=20 signaling pathways involved in that process as well, such as PDGF = and SHH.=20 While the PDGFRA-cocluster group is enriched for Proneural = signature=20 genes, it is important to note that the original signature was = derived=20 from a dataset of mixed histologies and the analysis designed = specifically=20 to resolve a prognostic signature. Therefore the exact = relationship=20 between our PDGF proteomic class, the PDGFRA co-cluster, and = gliomas=20 harboring Proneural signature is unclear and will need to be = further=20 investigated.

Although PDGFRA = amplification=20 predominated in the PDGFRA-cocluster transcriptomal group, a full = 15%=20 showed amplified EGFR and another 15% showed amplified=20 MET. From the prevalence of PDGF signaling we found at = the=20 protein level one might hypothesize the existence of concurrent = PDGF=20 signaling in EGFR- and MET- amplified tumors in = this=20 class. In fact, we found two such tumors in our proteomic = analysis: one=20 EGFR- and one MET-amplified, both with high = levels of=20 PDGFB, phosphorylation of PDGFR=CE=B2 and an overall signaling = pattern matching=20 the PDGF proteomic class. It is unclear in these cases whether the = level=20 of PDGF pathway activation is functionally important, perhaps in a = subpopulation of cells. It is notable that 6 tumors in TCGA show = focal=20 amplification of both PDGFRA and another RTK: four cases = sharing=20 focal co-amplification of EGFR, and two cases sharing = focal=20 co-amplifications of PDGFRA and MET.

In conclusion, our = findings support a=20 division of GBMs into three classes according to patterns of = signal=20 transduction pathway activation. These patterns reflect, in part, = mutually=20 exclusive signaling involving EGFR, PDGF RTK activation or NF1 = silencing.=20 Both the transcriptomal and proteomic classes were imperfectly = related to=20 genotype, suggesting that molecular assays used in patient = stratification=20 and clinical trial analysis should include measures of PDGF ligand = and=20 receptor phosphorylation as well as NF1 expression. Notch = signaling was=20 prominently associated with the EGFR class at the protein level, = an=20 observation which was not predicted by mRNA expression levels of = Notch=20 pathway members in EGFR-altered tumors from TCGA. Whether one or = more=20 non-EGF/PDGF RTKs are contributing to NF1 tumors is uncertain, but = the=20 finding that NF1-silenced tumors show elevated MET, HGF and IRS1 = at the=20 transcriptomal level and validation of IRS1 at the protein level = suggest=20 IGF and or MET signaling may be contributory. Further refinement = of GBM=20 subclasses will likely come from direct investigations of these = and other=20 signaling proteins, as well as investigation of newly described = recurrent=20 mutations in GBM such as ERBB2 and IDH1. The current study = provides an=20 initial architecture for such subclasses and suggests the = potential for=20 class-directed therapies.

Methods

Ethics statement

The collection and = use of the=20 human tissues in this study were performed after obtaining written = consent=20 from all participants, in accordance with a study protocol = approved by the=20 Institutional Review Board of Memorial Sloan-Kettering Cancer = Center. Data=20 from The Cancer Genome Atlas public portal were obtained under an = approved=20 Data Access Request.

Surgical glioma sample = analysis

Tumor=20 samples

Tumors were = snap-frozen in the=20 operating room, and stored at =E2=88=9280=C2=B0C. Samples in = liquid nitrogen were=20 ground to powder and protein was extracted through lysis with = T-per tissue=20 extract solution (Pierce) supplemented with 30 mM sodium fluoride, = 1 mM=20 sodium vanadate, and protease inhibitor cocktail tablets (Roche). = Protein=20 concentrations were determined by bicinchoninic acid assay (BCA) = method=20 (Bio-Rad).

Western blot=20 analysis

Samples (100 = =C2=B5g) were separated=20 by 6, 8, 10, or 12% SDS-PAGE gel, and transferred onto = polyvinylidene=20 difluoride membrane (Millipore). For qualitative comparison, = analysis=20 included normal brain cortex lysate as previously described = (Analytical=20 Biological Services Inc).[30] Membranes were blocked = with 5%=20 nonfat milk in PBS-0.1% Tween 20. Primary and secondary antibodies = were=20 diluted in the blocking solution. Signal was visualized using = enhanced=20 chemiluminescence (Amersham Biosciences). Primary antibodies used = in this=20 study are listed in Table S1. Secondary = peroxidase-conjugated=20 anti-rabbit antibody (Amersham Biosciences), anti-mouse and = anti-goat=20 antibodies (Roche) were used at 1 3D[ratio]=20

1,000 dilution. For NF1, 50 ug of lysate was run on 6% = gel and=20 secondary antibody was 1 3D[ratio]=20

10,000 dilution. PDGFR=CE=B1 total protein was assayed = at a later date=20 by western blot of frozen banked lysate aliquots (Santa Cruz, = #sc-338,=20 1 3D[ratio]=20

500, secondary 1 3D[ratio]=20

10,000). Because of low band intensity a second = PDGFR=CE=B1 antibody=20 was tested as well and gave concordant results (Cell Signaling = #3174,=20 1 3D[ratio]=20

1000, secondary 1 3D[ratio]=20

2,000). The density of each band was read and = quantified using=20 Adobe Photoshop and NIH Image 1.63 software and normalized by = actin=20 control. PDGFR=CE=B1 western was normalized to = tubulin.

Activated ras=20 pull-down assay

Activated K-ras = (K-ras-GTP) was=20 tested by using 500 =C2=B5g samples for activated Ras pull-down = with 10 =C2=B5g of=20 glutathione-conjugated Raf-1 GST-RBD beads (Upstate Biotechnology) = as=20 previously described.[31]

Unsupervised=20 clustering of protein data

Quantified western = data were=20 standardized for each protein by mean and standard deviation = across the=20 sample cohorts. Standardization was done first on the glioblastoma = samples=20 (n 3D"

=3D

20) for unsupervised clustering analysis of protein = level, then=20 again separately on the whole sample set (n 3D"

=3D

27) for cluster analysis of samples. For the purpose of = display,=20 NF1 is represented as =E2=80=9CNF1-loss=E2=80=9D, or zero minus = standardized NF1 quantity=20 on western. All statistical analyses and plotting were done in R = (http://www.cran.org/).=20 Principal component analysis was performed on standardized data. = K-means=20 clustering of quantified protein levels for 20 GBM samples was = performed=20 in R, and stability of cluster assignment assessed over 10,000 = iterations=20 leaving out 15% of tumors with each iteration (kmeans, stats = package,=20 http://www.cran.org/).=20 Consensus matrices were generated for each k-clustering over all=20 iterations and assessed visually as well as by cophenetic = correlation.=20 Core correlated protein clusters are defined for 3-way clustering = as=20 >95% consensus. Proteins in these core clusters were selected = for=20 k-means analysis of 27 gliomas using, as before, an 85% resampling = of=20 proteins and consensus matrix analysis over 10,000 = iterations.

ACGH and=20 resequencing

Genomic DNA was = extracted from=20 primary tumors using standard techniques. DNA was then digested = and=20 labeled and hybridized to 244K CGH arrays according to = manufacturer=20 guidelines (Genomic DNA labeling kit PLUS, Agilent). This array = consists=20 of >238,000 coding and non-coding sequences allotted to = assembly map=20 positions (NCBI, Build 35). Normal male genomic DNA (Promega, = Madison, WI)=20 was used as a reference. After washing, the slides were scanned = with an=20 Agilent scanner and images quantified using Feature Extraction = 9.5.3.1=20 (Agilent). Fluorescence ratios of the scanned images were = calculated and=20 the raw aCGH profiles were processed to identify statistically = significant=20 transitions in copy number using the Circular Binary Segmentation=20 algorithm.[32] Each profile was centered so = that log2=20 ratio of zero is assigned to the predominant copy number, = determined by=20 the mode of the distribution of the mean log2 ratio for each = segment,=20 weighted by the number of probes per segment . After = mode-centering, gains=20 and losses for a subset of analyses were defined as segment mean = log2=20 ratios of >0.2 or <=E2=88=920.2 and amplification and = deletions as >2 or=20 <=E2=88=921, respectively. Additionally, sample-specific = thresholds for=20 alterations were computed for all other analyses. The annotated = microarray=20 data for the sample set is available on GEO (www.ncbi.nlm.nih.gov/geo,=20 GSE17381)= .

Integrated analysis of genomic = data from=20 The Cancer Genome Atlas

Dataset=20 compilation and analysis

A description of TCGA = data types,=20 platforms and analyses are as previously described.[8] Processed genomic datasets = were=20 downloaded from The Cancer Genome Atlas public data portal (http://cancergenome.nih.gov/dataportal/<= /A>)=20 as available on May, 2009. Specific data sources were as follows: = For mRNA=20 expression, =E2=80=9CLevel 3=E2=80=9D normalized gene expression = derived from the Cancer=20 Genome Characterization Center (CGCC) at the Broad Institute, MIT=20 (Affymetrix Human Genome HTS U133A 2.0). For chromosomal copy = number,=20 =E2=80=9CLevel 3=E2=80=9D normalized and segmented copy number = data from the CGCC at=20 Memorial Sloan-Kettering Cancer Center (Agilent 244K CGH Array). = From this=20 array-CGH dataset one unique profile was selected for each tumor = based on=20 the highest signal-to-noise estimate. For sequencing data, we = combined all=20 available sequencing data summaries in =E2=80=9Cmultiple alignment = format=E2=80=9D (MAF)=20 files as of May 2009: broad.mit.edu GBM.ABI.1, genome.wustl.edu=20 GBM.ABI.53, hgsc.bcm.edu GBM.ABI.1.maf and GBM.ABI.2. Mutations = were=20 further filtered by excluding events which were classified as = =E2=80=9Csomatic,=E2=80=9D=20 =E2=80=9Csynonymous=E2=80=9D or =E2=80=9Csilent,=E2=80=9D or = =E2=80=9Cunvalidated,=E2=80=9D

A list of the sample IDs = and the=20 summary of genomic data are given in Table S3. 243 samples had gene = expression from=20 Affymetrix U133A platform. Of these, 237 also had aCGH data and = 159 had=20 mutation data available. Level 3 array-CGH data was used for local = copy=20 number estimation. Amplification was defined by regional log2 = ratio=20 >2.0. Gene loss was classified by minimal log2 ratio (log2R) = across the=20 gene as follows: =E2=80=9Csingle copy loss=E2=80=9D 3D"

=3D

=E2=88=921.0<log2R<=E2=88=920.2; = =E2=80=9Chomozygous deletion=E2=80=9D 3D"

=3D

log2R<=E2=88=921.0.

Clustering of TCGA expression dataset

Unsupervised = clustering of TCGA=20 Level 3 expression data was performed on 1,807 genes representing = the top=20 15%ile of variance (hierarchical clustering, correlation metric, = complete=20 linkage; hclust, R package:stats,). Supervised cluster analysis = was=20 performed as follows: 147 samples were identified harboring only = one of=20 either EGFR mutation/amplification (n 3D"

=3D

103), PDGFRA mutation/amplification (n 3D"

=3D

14) or NF1 mutation/loss (n 3D"

=3D

30). Kruskal-Wallis (kruskal.test, R package:stats) = test was used=20 to identify genes which discriminate between EGFR-, PDGFRA- and=20 NF1-altered samples. Because only 14 samples in TCGA set harbor = solitary=20 PDGFRA alteration, the numbers of profiles in each class are = balanced by=20 sampling 14 of the 103 EGFR-altered and 14 of the 30 NF1-altered = samples=20 and the KW test is run iteratively 1000 times with resampling. = 1,953 genes=20 were found to show KW p-values <0.05 in >95% of iterations = and these=20 were used to perform supervised hierarchical clustering. = Calculation of=20 significance for differences between cluster was by Fisher's Exact = Test (R=20 package:stats) using cluster assignments for PDGFRA, NF1 and=20 EGFR-coclusters derived from unsupervised clustering, and = excluding=20 samples belonging to the =E2=80=9CIndeterminate Genotype=E2=80=9D=20 cluster.

Supporting=20 Information

Figure S1

Selected bands from western blots = which were=20 quantified in this study. Signaling class assignments are shown = for those=20 samples with stable clustering: =E2=80=9CP=E2=80=9D 3D"

=3D

PDGF class, =E2=80=9CN=E2=80=9D 3D"

=3D

NF1 class, and =E2=80=9CE=E2=80=9D 3D"

=3D

EGFR class.

(6.30 MB TIF)

Click=20 here for additional data file.^{(6.0M, =
tif)}

Figure S2

Principal Componenet Analysis of = Quantified=20 Protein Levels: Fractional variance for principal components from = the=20 analysis of quantified protein levels in 20 GBM samples. The first = two=20 components together account for 51% of total variance and are = plotted in=20 Figure 1A

(0.34 MB TIF)

Click=20 here for additional data file.^{(334K, =
tif)}

Figure S3

Analysis of stable cluster = assignment by=20 k-means for varying cluster count: K-means clustering of = quantified and=20 standardized protein levels in GBM; classification of gliomas by = core=20 protein expression patterns. For each analysis, K-means was run = for 10,000=20 iterations leaving out 15% of data with each iteration. Shown are=20 consensus matrices for division into 2=E2=80=934 clusters, and = cophenetic=20 correlations for division into 2=E2=80=938 clusters. (A) = Clustering of 55 proteins=20 in 20 GBM samples shows stable two-way and three-way clustering = with peak=20 cophenetic correlations ~0.98. Details for 3-way clustering are = shown in=20 Figure 1B

=20 in the main text. Three sets of =E2=80=9Ccore=E2=80=9D proteins = (n 3D"

=3D

46 total) are defined by their stable cluster = membership in=20 >95% of iterations. (B) 27 glioma samples clustered by 44 core = proteins=20 identified in the preceding analysis and highlighted in Figure 1B

.=20 Gliomas are classified into 3 types based on the levels of 44 = total and=20 activated protein forms.

(1.04 MB TIF)

Click=20 here for additional data file.^{(1012K, =
tif)}

Figure S4

Genomic profiling of gliomas = clustered by=20 signaling class: Array-CGH shows high concordance between EGFR = signaling=20 class and amplification of EGFR locus and deletion of the = Ink4a/ARF locus.=20 Tumors in the NF1 class show frequent gain of chr7 without focal=20 amplification of either EGFR or MET. Of the two tumors which do = have focal=20 MET amplification, one clusters with EGFR-class and the other with = PDGF-class. No amplification of PDGFRA was found in any of the=20 samples.

(0.96 MB TIF)

Click=20 here for additional data file.^{(934K, =
tif)}

Figure S5

Expression of Proneural and = Mesenchymal=20 signature genes in transcriptomal subclasses: Expression analysis = of=20 Proneural and Mesenchymal signature genes across transcriptomal = subclasses=20 derived from The Cancer Genome Atlas. Unsupervised clustering of = TCGA=20 samples and subclass assignments are as shown in Figure 4

.=20 Tumor profiles in each subclass are assessed for enrichment of = signature=20 genes defining the Proneural and Mesenchymal transcriptomal = classes of GBM=20 previously described [19]. Box plots show the = distribution of=20 mean percentile rank for expression of Proneural and Mesenchymal = signature=20 gene sets courtesy of Kenneth Aldape, MD: Proneural

=3D

BMP2, GRIA2, OMG, NCAM1&2, OLIG2, BCAN, RTN1, = SNAP91,=20 GABBR1&2, and KCNB1; Mesenchymal

=3D

YKL40/CHI3L1, IGF2BP3, VEGFA, COL1A1, COL5A2, = COL3A1.

(0.35 MB TIF)

Click=20 here for additional data file.^{(345K, =
tif)}

Figure S6

Supervised transcriptomal = clustering of GBM=20 tumors in The Cancer Genome Atlas: Clustering of 243 GBM samples = form TCGA=20 using ~1,900 genes selected for their ability to discriminate = three=20 genotypes: EGFR mutation/amplification, PDGFRA = mutation/amplification or=20 NF1 mutation/deletion (see Methods). Sample set and figure legend are as shown = in Figure 4

=20 and clustering methods differ only in the subset of genes used. = Samples=20 are clustered into three divisions each enriched for one of the = three=20 genotypes.

(0.91 MB TIF)

Click=20 here for additional data file.^{(891K, =
tif)}

Figure S7

PDGFB protein levels are not = correlated with=20 mRNA expression: PDGFB protein levels were assessed in a = validation panel=20 of 40 gliomas by western blot and compared with mRNA expression = levels.=20 Although the ligand is expressed at highly variable amounts there = is no=20 correlation with mRNA, concordant with post-transcriptional = regulation of=20 PDGF.

(0.77 MB TIF)

Click=20 here for additional data file.^{(750K, =
tif)}

Table S1

Antibodies and conditions used for = western=20 blot panel. Antibody sources and conditions as shown. *Hes1 = antibody=20 kindly provided by Dr. Tetsuo Sudo (Toray Scientific, = Japan).

(0.03 MB XLS)

Click=20 here for additional data file.^{(27K, =
xls)}

Table S2

Quantified western results. = Western bands=20 quantified by densitometry and normalized to actin (see Methods). Images of selected bands are shown in Figure S1.

(0.05 MB XLS)

Click=20 here for additional data file.^{(53K, =
xls)}

Table S3

Summary of integrated analysis of = genomic data=20 from 278 samples in The Cancer Genome Atlas. In this table, = mutations are=20 denoted in blue and designated =E2=80=9Cvalidated=E2=80=9D and = =E2=80=9Cunvalidated=E2=80=9D according to=20 whether TCGA reports that the mutation was verified by second = sequencing=20 method or whether such verification is pending. Focal = amplifications in=20 red and single-copy loss or homozygous deletion (light and dark = green,=20 respectively) are inferred from array-CGH log2 ratios (see Methods). Cluster assignments are derived from Figure 4

(0.08 MB XLS)

Click=20 here for additional data file.^{(76K,=20
xls)}

Acknowledgments

The authors would like to thank = David Gutmann,=20 MD, PhD, and Ken Aldape, MD, for helpful discussions. The results=20 published here are in part based upon data generated by The Cancer = Genome=20 Atlas pilot project established by the NCI and NHGRI. Information = about=20 TCGA and the investigators and institutions who constitute the = TCGA=20 research network can be found at http://cancergenome.nih.gov/.=

Footnotes

Competing = Interests:=20 The authors have declared that no competing interests=20 exist.

Funding: = This=20 work was supported by NIH U24 CA126543-01, CA100688,=20 CA126518,=20 CA141502,=20 and CA143798=20 and by the Geoffrey Beene Cancer Research Center at Memorial=20 Sloan-Kettering Cancer Center, which had no role in study design, = data=20 collection and analysis, decision to publish, or preparation of = the=20 manuscript.

References

1. Furnari FB, Fenton T, Bachoo RM, = Mukasa A,=20 Stommel JM, et al. Malignant astrocytic glioma: genetics, biology, = and=20 paths to treatment. Genes Dev.=20 2007;21:2683=E2=80=932710. [PubMed]

2. Holland EC. Glioblastoma multiforme: = the=20 terminator. Proc Natl Acad Sci U S = A.=20 2000;97:6242=E2=80=936244. [PubMed]

3. Wen PY, Kesari S. Malignant gliomas = in adults.=20 N Engl J Med. 2008;359:492=E2=80=93507. [PubMed]

4. Maher EA, Furnari FB, Bachoo RM, = Rowitch DH,=20 Louis DN, et al. Malignant glioma: genetics and biology of a grave = matter.=20 Genes Dev. 2001;15:1311=E2=80=931333. [PubMed]

5. Louis DN, Ohgaki H, Wiestler OD, = Cavenee WK,=20 Burger PC, et al. The 2007 WHO classification of tumours of the = central=20 nervous system. Acta Neuropathol.=20 2007;114:97=E2=80=93109. [PubMed]

6. Yan H, Parsons DW, Jin G, McLendon = R, Rasheed=20 BA, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360:765=E2=80=93773. [PubMed]

7. Parsons DW, Jones S, Zhang X, Lin = JC, Leary=20 RJ, et al. An integrated genomic analysis of human glioblastoma=20 multiforme. Science. = 2008;321:1807=E2=80=931812. [PubMed]

8. Network TI. Comprehensive genomic=20 characterization defines human glioblastoma genes and core = pathways.=20 Nature. 2008;455:1061=E2=80=931068. [PubMed]

9. Lamborn KR, Yung WK, Chang SM, Wen = PY,=20 Cloughesy TF, et al. Progression-free survival: an important end = point in=20 evaluating therapy for recurrent high-grade gliomas. Neuro Oncol. 2008;10:162=E2=80=93170. [PubMed]

10.=20 CSM MehtaMP, Vogelbaum MA, Guha A., = editors.=20 Principles and Practice of = Neuro-Oncology - A=20 Multidisciplinary Approach. New YOrk: Demos Medical = Publishing;=20 2009. Supratentorial gliomas.

11. Lassman AB, Rossi MR, Raizer JJ, = Abrey LE,=20 Lieberman FS, et al. Molecular study of malignant gliomas treated = with=20 epidermal growth factor receptor inhibitors: tissue analysis from = North=20 American Brain Tumor Consortium Trials 01-03 and 00-01. = Clin Cancer Res. 2005;11:7841=E2=80=937850. [PubMed]

12. Huse JT, Holland EC. Genetically = engineered=20 mouse models of brain cancer and the promise of preclinical = testing.=20 Brain Pathol. 2009;19:132=E2=80=93143. [PubMed]

13. Fomchenko EI, Holland EC. Mouse = models of=20 brain tumors and their applications in preclinical trials. = Clin Cancer Res. 2006;12:5288=E2=80=935297. [PubMed]

14. Nutt CL, Mani DR, Betensky RA, = Tamayo P,=20 Cairncross JG, et al. Gene expression-based classification of = malignant=20 gliomas correlates better with survival than histological = classification.=20 Cancer Res. 2003;63:1602=E2=80=931607. [PubMed]

15. Mischel PS, Shai R, Shi T, Horvath = S, Lu KV,=20 et al. Identification of molecular subtypes of glioblastoma by = gene=20 expression profiling. Oncogene.=20 2003;22:2361=E2=80=932373. [PubMed]

16. Freije WA, Castro-Vargas FE, Fang Z, = Horvath=20 S, Cloughesy T, et al. Gene expression profiling of gliomas = strongly=20 predicts survival. Cancer Res.=20 2004;64:6503=E2=80=936510. [PubMed]

17. Liang Y, Diehn M, Watson N, Bollen = AW, Aldape=20 KD, et al. Gene expression profiling reveals molecularly and = clinically=20 distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci U S A. 2005;102:5814=E2=80=935819. [PubMed]

18. Tso CL, Freije WA, Day A, Chen Z, = Merriman B,=20 et al. Distinct transcription profiles of primary and secondary=20 glioblastoma subgroups. Cancer = Res.=20 2006;66:159=E2=80=93167. [PubMed]

19. Phillips HS, Kharbanda S, Chen R, = Forrest WF,=20 Soriano RH, et al. Molecular subclasses of high-grade glioma = predict=20 prognosis, delineate a pattern of disease progression, and = resemble stages=20 in neurogenesis. Cancer Cell.=20 2006;9:157=E2=80=93173. = [PubMed]

20. Rajasekhar VK, Viale A, Socci ND, = Wiedmann M,=20 Hu X, et al. Oncogenic Ras and Akt signaling contribute to = glioblastoma=20 formation by differential recruitment of existing mRNAs to = polysomes.=20 Mol Cell. 2003;12:889=E2=80=93901. [PubMed]

21. Rajasekhar VK, Holland EC. = Postgenomic global=20 analysis of translational control induced by oncogenic signaling.=20 Oncogene. 2004;23:3248=E2=80=933264. [PubMed]

22. Choe G, Horvath S, Cloughesy TF, = Crosby K,=20 Seligson D, et al. Analysis of the phosphatidylinositol = 3=E2=80=B2-kinase=20 signaling pathway in glioblastoma patients in vivo. Cancer Res. 2003;63:2742=E2=80=932746. [PubMed]

23. Beroukhim R, Getz G, Nghiemphu L, = Barretina J,=20 Hsueh T, et al. Assessing the significance of chromosomal = aberrations in=20 cancer: methodology and application to glioma. Proc Natl Acad Sci U S A. 2007;104:20007=E2=80=9320012. [PubMed]

24. Maher EA, Brennan C, Wen PY, Durso = L, Ligon=20 KL, et al. Marked genomic differences characterize primary and = secondary=20 glioblastoma subtypes and identify two distinct molecular and = clinical=20 secondary glioblastoma entities. Cancer Res.=20 2006;66:11502=E2=80=9311513. [PubMed]

25. Lee JC, Vivanco I, Beroukhim R, = Huang JH, Feng=20 WL, et al. Epidermal growth factor receptor activation in = glioblastoma=20 through novel missense mutations in the extracellular domain. = PLoS Med. 2006;3:e485. doi: 10.1371/journal.pmed.0030485<= /SPAN>.=20 [PubMed]

26. Verhaak RGW, Hoadley KA, Purdom E, = Wang V, Qi=20 Y, et al. An integrated genomic analysis identifies clinically = relevant=20 subtypes of glioblastoma characterized by abnormalities in PDGFRA, = IDH1,=20 EGFR and NF1. Cancer Cell In Press. = 2009

27. Pech M, Rao CD, Robbins KC, Aaronson = SA.=20 Functional identification of regulatory elements within the = promoter=20 region of platelet-derived growth factor 2. Mol Cell Biol. 1989;9:396=E2=80=93405. [PubMed]

28. Rao CD, Pech M, Robbins KC, Aaronson = SA. The=20 5=E2=80=B2 untranslated sequence of the c-sis/platelet-derived = growth factor 2=20 transcript is a potent translational inhibitor. Mol Cell Biol. 1988;8:284=E2=80=93292. [PubMed]

29. Codeluppi S, Svensson CI, Hefferan = MP,=20 Valencia F, Silldorff MD, et al. The Rheb-mTOR pathway is = upregulated in=20 reactive astrocytes of the injured spinal cord. J Neurosci. 2009;29:1093=E2=80=931104. [PubMed]

30. Lyustikman Y, Momota H, Pao W, = Holland EC.=20 Constitutive activation of Raf-1 induces glioma formation in mice. = Neoplasia. 2008;10:501=E2=80=93510. [PubMed]

31. Dai C, Lyustikman Y, Shih A, Hu X, = Fuller GN,=20 et al. The characteristics of astrocytomas and oligodendrogliomas = are=20 caused by two distinct and interchangeable signaling formats. = Neoplasia. 2005;7:397=E2=80=93406. [PubMed]

32. Olshen AB, Venkatraman ES, Lucito R, = Wigler M.=20 Circular binary segmentation for the analysis of array-based DNA = copy=20 number data. Biostatistics.=20 2004;5:557=E2=80=93572. = [PubMed]

Figure=20 4

Unsupervised=20 transcriptomal clustering of GBM from the TCGA = dataset.

PubMed articles by these = authors

Brennan,=20 C.
Momota,=20 H.
Hambardzumyan,=20 D.
Holland,=20 E.

PubMed related articles

Contribution=20 of Notch signaling activation to human glioblastoma = multiforme.=20
J Neurosurg. 2007 Mar; = 106(3):417-27.=20

[J Neurosurg. 2007]
Comparative=20 analyses of gene copy number and mRNA expression in glioblastoma = multiforme tumors and xenografts.=20
Neuro Oncol. 2009 Oct; = 11(5):477-87. Epub=20 2009 Jan 12.

[Neuro Oncol. 2009]
Active=20 matrix metalloproteinase 9 expression is associated with primary = glioblastoma subtype.=20
Clin Cancer Res. 2002 Sep; = 8(9):2894-901.=20

[Clin Cancer Res. 2002]
ReviewTargeted molecular therapy of = GBM.=20
Brain Pathol. 2003 Jan; = 13(1):52-61.=20

[Brain Pathol. 2003]
ReviewSignal transduction pathways and = their=20 relevance in human astrocytomas.=20
J Neurooncol. 1997 Dec; = 35(3):223-48.=20

[J Neurooncol. 1997]
=C2=BB See=20 reviews... | =C2=BB See=20 all...

Recent Activity

=20

Clear=20 Turn=20 Off Turn=20 On

Your browsing activity is empty.

Activity recording is turned off.

Turn=20 recording back on

Simple NCBI Directory

Getting Started
Site Map=20
NCBI=20 Help Manual=20
NCBI=20 Handbook=20
Training=20 & Tutorials

NCBI Information
About NCBI=20
Research at = NCBI=20
NC= BI=20 Newsletter=20
NCBI FTP Site=20
Conta= ct=20 Us

NIH DHHS USA.gov

National Center for Biotechnology=20 Information , U.S. National Library of=20 Medicine 8600 = Rockville=20 Pike, Bethesda MD,=20 20894 USA=20

------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/pmc3_logo_v5.gif R0lGODlhkQBLAMYAAKm5x+v0+IekvHefv+Tp7liXuQBcknmcuoapxDqGrsXP3yhpmrnEzrzL3FqG qgFmmTp1os7W3YWyysPT4Uh4peHn7Oru88TN1ip7p8nS2Rxjl6zB1ejs8d3k6mmStfP6+6zE2Nrg 5kKLsb7I0bbBy9Lm7sfP2HKlwy9tnLnU4pGswaW+0kyCqpvB1bfJ3GWRs9La4A5YkGGcvOLo7a/N 3dvi57nQ3qLD1s7c5pq1y6+8x5+zxLDG2JK4ztXc45e80cLZ5drq8eXq78vg6rXG1HmrxmGOsMne 6WCKrtnf5ZGyy1mKsDVyoMrT4rvGz3Cau9/l68PM1cDJ0k6Stunt8Rdvn2mhv1N9qNfg6dDX39Pe 6n+uyIe40MHL1OTv9XWoxefr76DG2Nbd4+Lu9J+4zRlflNnj68Xe6pexxu7w8dHa59nd6afJ2uvu 8G6Wtufs8OHo8dTb4urt8MvU2+zv9dLc5evu9ezr8maUtwBPiuzx9P///2aZzDNmmczY5Ozw9CwA AAAAkQBLAEAH/oB7goOEhYaHiImKi4yNjo+Qinx+lJWWl5iZmpuclX+foKGio6SlpqeoqaJ8gpOd lVhbVhJee2NAXC1DjEGyWxWvnqqhEHlLG0t5eTkVBG9UFp88ymBCQs/TMXksFRN52hAVMwRg0KPT edXX5qase66YTywe9EYoGgv5GvP19/ooSzy88LAEn74qCaYonFJFgxJNw0BRKebhghMGDJwgURaj TB4kAvIwUZbHDYOQKEg4yHMFwMoFOnRoIAmBBAkUynDmIcGgS4QkFai0a7XpxA8FE04YuCGkQgUw Mno0aFAgT4+mFYRIAOGiiQgDNmZAgTLDBgikCQy0mAExIigL/nA74IEAQYkFKlTe6H3DAS+Hv33x WuDBwwzew9AQBx4wwM/evnBRuYN3yUoCGQVkMDRAgwCBLwkyY66yFMyME1MKqC7wIAEUpxIuiyYN pK3bT1S0LTHBQNuAYi9MqDCiQoWyC8bzSBmhTACDlShGSNEmwAROI8zzqBgRJYKYDmCinZocrLz5 87dD3W3aIUSSJCFqdOhQo379+fjz068RIr78+fz1199/ZAnBznhEVeJBHwzq4aCDDEYo4YQUVtgH hBZ6cEkoZFiIoYUghjjhhxfqMaKJHkpIRijkVaIABSLGKCOIFEywoURIzKjjjjyCiIRQoLR43pBE 3pjekUgm/hlkgkU2OaSSUEY5jJBOFhHaLnsEcYIIJzgpjJRghrnkO5mgwUIZEDiAhANXoLDAFQ6w ecWcdNZp5510rolCGS8QkcltFhRDUkkM4PTCHCO5QYYyGUShDBo5iBRSMUhshIITOJXBhEduuCFS EovmYYIJGcBQwwxAkkLlJUWwsYYWWzyAQQK00npDE2pURasIIiSAwQRNmDGFARj0SusPE7z6FRub AApGBTX4AIMPIXQARQdJZJHBBVF00cUFJkQB7qgZzDFHBuVmQCq65Z5LLrrmqktuFklAIYR4qjKJ yRc0YNHAF0sR4BRUNkxV1VUD93BEV1+FNd8MKQDRxARp/rXQ7JHe5LFCEjAI0CcR3zwRQwxYgKCM BjPFQICgInlaTF15oDCAMmTMoMzGSXSQVapDkenlz68gScUMNcDQaBfiXsDtCBg54bR0F40wghPS Lef000hHIcVFNvFE9QX0QvFGKqsCbbYlYqYNJpUUPtjggx/CXWKEJM5tt4RG/gEihBjyjaLfdP+N YomAB34i4YPXzaK+Zzfuh9qQK1m240BHbnl6k1Pu5eWcT8n4z7063vnoCPpMpAQFbFFLALi0EAAh eqAmQZPpKcEYYyvAhS8oODAmSu+M4QCX7QPYtfsowLuVeSU9bLFFEIIMEQYbQHwQCSFAfLHFDx1w Amgx/k+IcYEyLyTaQTEDbKAMBRSI1MEKeUAwEhEs5OGBSFmAHIPIJGOhDR46SYIYcjaD8PSMMpVQ AQ6ux8BBNOAKf3JLoOx3AQZ0DSdIGMF1kmPBRxkHBQzwSB508BIdjAQJUhiOCjyFAuEoAyPdAQrP VvE5SmAGAzjEQBUewEMe5hCHO+yhrH4oRB8SsQo4sM0wLECAom3rAhmIQBayMAeLYKRrFvRaRqSG kSzypGlTa9rTwrhFE8AgBEE5YFGOkhQDsCENcpBDGqJisDz8AI5y3ArDDDCDNoABDG1IwVkoppaL SfANQpiBOK7BATAQAAo1eM97BAQf/1hLP/q5ln3u/kMfAcmngAcaxfKMghSl3OCRWaEjVazySCgQ QI9eAUsF5lMBs6ClkEq8TTJiQAYEKGMCzXjG8UahDBD8UZimKKY1yhEZydSQElsowR7SsAU3vmEc crBCLTpQlR/IQQiAnMLr7jAsIGAFDH6wHhy+EgZD3gYdZKiity6QqU2VJFSgUkYcYPCoCxghD2WI wLQ24AYmaMMN/MwDGsp1xgqMzZmmu0QPEmCFihZBBAvAgrV+IIKKVlQEGMBBBaAgg4561FdmmM8P MCCBim5BBFWoTQTTw4E6jIQkByjXAmhCgpDk4SQvJIGgUAAdnugkBsVwgA6awwApzOE7BiwdAjX3 /jMkWeCaNYjDHEa1LneRilTmOldY5xABr4JVimU1gdKiEAWwZuE7qCLbM6laJCjBBS98QYxfAqNX vXJAL3z1C2D5qjvPRdQPIIBRjxY7IQqAABOigEKOGEvZyk4ICVCgYUQN1za3va1vnpXb3OrGoLzt TXCgfRviEJe40A7ubqpdrWgZtLjNxna0grNb4XRrotROKG+KjW3hhtvb1qo2tSSqG3FhS4HaTrUJ AoCAZXcEAQE0YaYSIUNwp8tdGVGADDP8w/Lo+iTSmVezDUyvetfL3vZKgg/wja9850vf+tr3vvjN r373y9/++pe+cyUves5LYPEGWMDlKTCBx4vg/mAo+LwMbnAnHmzeCAfjDUoQgQxK+oWzUZh0Fi7K FE4AvQAM4XV78MJLt7C5D3cuxJYoQgG+UAsvpIALXMCSIbRwggIUwQzldQvLlMECMAgTX+i4CzQG Q5IB/GUm8fvLkkmRZMEMU7NTzcQNkEWDAHzgCC2gARCk+QgvsIEGPbiBg28DPmwpww1GgIAKhDAX JaDjBXlYgAsIYLJixCAEvmwfE/qTg5mgwAZwWcFMkpGHkRYolFjeBGa+AAQH0aAIW6ABHOwgBDh4 +tOgDnWohUAHOgDBCiLocC5TMUEmeGCnedgBTjwghpE8AX6iAlkeXLAoJiTjAGVAAZ5RcAE8/i8h CU9YRqQ0UIFI5SELUswZAa78ickJQAVNaAAPQLABHrigAS4AgbjHTe5ym/vc3vbDACAIWQkWgwVo UMEFPxKFWaNBGVJggDKKEzMAkEQARcWJsF/wAjTgmQlZuHcepAY2NIZ3TFl2AxoasIINWLwBCsh4 xnlg8YtrPOPc7vjHQb6CG5jcBUCILnZVMREKehEnEDiANkDSnAN8A6gpGckCXJJnHbCwUNpROAk2 8tOe/CSNpcicBMKwhwAEoARp6aEBwuD0p3+Fh8QCQtWHIEQDVIEGH/BCAMaQgDxgYdWosIALVkAE EyxHXCY4gBEAoAIB7AAAAsC7AwTAE7yj/oEBeN+BDuoub5u4wQFu6JoOBqIDATiHAVGgF9LzdVhL pKYIJ0hAEXlYgBOcAAMGKGIVZHCCLwRRiBiwwhdOsMMioHPlrBZCB8RQ1jnAYIBiMFoXyEg1p0nh 99+6QBeksHupER9pwgf+PIVftShkIA6neni150pKBSilB2nI/hx78O2qbEH7FdgCVybwFRxoPw00 OIsNKuZOVdzlkfdpRiKhwDFoR0CKU8Q/DG4vBh/4QAz7FAf+938AuH/7FwdikHtTlAW31wEz8AbU ZmCVVwmk1EY3wAGeIQeqdDAYSAByAEsNc062REgWg3ZpdxdvYGRLRgUckEhO4RQzoEgv/jgO1lCD QuAZNniDMbiDnhGDMOgMkBZpmlCBpoRKQrCBrDQWr8QVsWQDs6QzI8h+JqgKOKANJIEH4AQZEfgJ ysADutNMo2ABXXgYYChVa1RKAfMaR/gDddQDApMVIAgWM/AwUYhLsBcRyvAEkDQTCJAEhRYziGYD dKEEI2MXeJATL6ACdbEEEGABA5AyA3AXyrABYzEDQsABWzh9E0gJRXAGadAAShEGWPEGMlACarBK PWAaHigCXqAGTdhKBDABY9AB62eH7ZYe6LACRqNWJoBnRhACyZYDuFYHuEYfNBMB95MHRkAECAAB K3A+efAENUAzDAhX0udcm4ABUyAB/lZiAAXgSARgBhiQOlZAGlPwR2BwA6NXBKb3ACeAFVggA7Nw AhpgAFPQfhHhB8qQA40id2QwEkxAcAWncBGgcOqybyNgKeAyMzFwJnkQHPvWVmHzUGaYCSfABSVw BEOQAmVHA+JgBT0wBBrJkXlwSlAgAmwgkkeQAjxkLRXQAxipkWcAejJ1i7fBAcmWBw6AEzHQBSjR BThRd8owAj6FEcqABCoAHRnRHDtwlPqWBwLgBF3wVOCRiTAmYTbpFlRQAUkwHG4AAOMSd0iQeCTQ eFFplhakA0+ABAewA9d2RR6ABADgloLneDpgdFAlV5uIlUFzJBYge7QXLmylNOEC/nzEt1bBB3fc 4i3ztC7MNzVUgzSlgkYcoJdZxpd9eSRU0BTRsoAM6AP7ZIDT0n8C2H8JKC0wMEX7l4AKaH8MKIA5 kxWZKIGXiZnekyR34UgzSAA6uIPj4BnAyZu9CYM0SAA+uJu8iUyWaZtB5mJlGCZl0wQH0F06cgDX lZV/YAHaRZ3cGSLfNUxU0gDS1Z06AgENkDdUMFnkuZ4W8iPYWAmcBVuWRVp4gzagsF0SQp/UmVyv JSIk0lwQZwn5yZ/HZThxk1tuQ1qm5SHFdVwIalyjZaCvpVwNilsT8p6UwKDyiVwQylkKap+fcFq8 NaIH6qAmGp+3JTeKE6CVMJ2fXHWgMLpbqzWiEnIAedMhAxqjgZOgEApaPJqjPzqjd7MiLFoJDYCf 7EkhFHCeefMHkpWkUMogmCWEzJlgLsY5V8mcV4qlB1alILqlkDMZ/zWmZFqmZnqmaApfexAIADs= ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/logo-plosone.gif R0lGODlh9QFLAOYAAABmmWZmZjMzmf///8/S1szMzLe8wXR1eFiGozxmgYyMjbKys8PZ5tjY2WBx n02NtHl5em9vcPX19evr7IKCg+Li4oizzcfO41VcccXFxvD1+CBwodLi7J+foD6DrW+Zs+Hs8mqg wJ2yv0CAp5CeyKbG2S96pz1Wn1lurby8vM/Pz7TP31yWuoKFiaioqZWVlvHy+HSGuuPm8S9KmHmp xtXa6rnC3Gd6tJe800tiph1tnsDFyJ6qz4KSway21mOTsFeMrbS/xZGsvHqftjR5pIamuUyGqqm5 wilzoYmNktvd4Ofp6nqAjnuVp3+LpW2FlgAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH/ C1hNUCBEYXRhWE1QPD94cGFja2V0IGJlZ2luPSLvu78iIGlkPSJXNU0wTXBDZWhpSHpyZVN6TlRj emtjOWQiPz4KPHg6eG1wbWV0YSB4bWxuczp4PSJhZG9iZTpuczptZXRhLyIgeDp4bXB0az0iMy4x LjEtMTExIj4KICAgPHJkZjpSREYgeG1sbnM6cmRmPSJodHRwOi8vd3d3LnczLm9yZy8xOTk5LzAy LzIyLXJkZi1zeW50YXgtbnMjIj4KICAgICAgPHJkZjpEZXNjcmlwdGlvbiByZGY6YWJvdXQ9IiIK ICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIj4K ICAgICAgICAgPGRjOmZvcm1hdD5pbWFnZS9naWY8L2RjOmZvcm1hdD4KICAgICAgPC9yZGY6RGVz Y3JpcHRpb24+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAg IHhtbG5zOnhhcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyI+CiAgICAgICAgIDx4YXA6 Q3JlYXRvclRvb2w+QWRvYmUgSWxsdXN0cmF0b3IgQ1MyPC94YXA6Q3JlYXRvclRvb2w+CiAgICAg ICAgIDx4YXA6Q3JlYXRlRGF0ZT4yMDA4LTAzLTA2VDEwOjQ4OjM4LTA4OjAwPC94YXA6Q3JlYXRl RGF0ZT4KICAgICAgICAgPHhhcDpNZXRhZGF0YURhdGU+MjAwOC0wMy0wNlQxMDo0ODozOC0wODow MDwveGFwOk1ldGFkYXRhRGF0ZT4KICAgICAgICAgPHhhcDpNb2RpZnlEYXRlPjIwMDgtMDMtMDZU MTA6NDg6MzgtMDg6MDA8L3hhcDpNb2RpZnlEYXRlPgogICAgICA8L3JkZjpEZXNjcmlwdGlvbj4K ICAgICAgPHJkZjpEZXNjcmlwdGlvbiByZGY6YWJvdXQ9IiIKICAgICAgICAgICAgeG1sbnM6eGFw TU09Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9tbS8iCiAgICAgICAgICAgIHhtbG5zOnN0 UmVmPSJodHRwOi8vbnMuYWRvYmUuY29tL3hhcC8xLjAvc1R5cGUvUmVzb3VyY2VSZWYjIj4KICAg ICAgICAgPHhhcE1NOkRvY3VtZW50SUQ+YWRvYmU6ZG9jaWQ6aWxsdXN0cmF0b3I6ZWVkYTk4YzIt ZWJhZC0xMWRjLWI1MWUtYWZjYjBkMTMxYjA3PC94YXBNTTpEb2N1bWVudElEPgogICAgICAgICA8 eGFwTU06SW5zdGFuY2VJRD51dWlkOjJCOUREOUE0QURFQkRDMTE5QzM3RUNEMENERTIxMjE3PC94 YXBNTTpJbnN0YW5jZUlEPgogICAgICAgICA8eGFwTU06RGVyaXZlZEZyb20gcmRmOnBhcnNlVHlw ZT0iUmVzb3VyY2UiPgogICAgICAgICAgICA8c3RSZWY6ZG9jdW1lbnROYW1lPnV1aWQ6Yjg2Yzgz MzEtY2ViYS00YTczLTk5ZDMtZmJlMTJiNGI2ODdlPC9zdFJlZjpkb2N1bWVudE5hbWU+CiAgICAg ICAgICAgIDxzdFJlZjppbnN0YW5jZUlEPnV1aWQ6NTZhNTU5ODgtZWJhZC0xMWRjLWI1MWUtYWZj YjBkMTMxYjA3PC9zdFJlZjppbnN0YW5jZUlEPgogICAgICAgICAgICA8c3RSZWY6ZG9jdW1lbnRJ RD5hZG9iZTpkb2NpZDppbGx1c3RyYXRvcjo1NmE1NTk4Ny1lYmFkLTExZGMtYjUxZS1hZmNiMGQx MzFiMDc8L3N0UmVmOmRvY3VtZW50SUQ+CiAgICAgICAgIDwveGFwTU06RGVyaXZlZEZyb20+CiAg ICAgICAgIDx4YXBNTTpWZXJzaW9uSUQ+MTwveGFwTU06VmVyc2lvbklEPgogICAgICA8L3JkZjpE ZXNjcmlwdGlvbj4KICAgICAgPHJkZjpEZXNjcmlwdGlvbiByZGY6YWJvdXQ9IiIKICAgICAgICAg ICAgeG1sbnM6ZXhpZj0iaHR0cDovL25zLmFkb2JlLmNvbS9leGlmLzEuMC8iPgogICAgICAgICA8 ZXhpZjpQaXhlbFhEaW1lbnNpb24+NTAxPC9leGlmOlBpeGVsWERpbWVuc2lvbj4KICAgICAgICAg PGV4aWY6UGl4ZWxZRGltZW5zaW9uPjc1PC9leGlmOlBpeGVsWURpbWVuc2lvbj4KICAgICAgPC9y ZGY6RGVzY3JpcHRpb24+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAg ICAgICAgIHhtbG5zOnRpZmY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vdGlmZi8xLjAvIj4KICAgICAg ICAgPHRpZmY6U2FtcGxlc1BlclBpeGVsPjM8L3RpZmY6U2FtcGxlc1BlclBpeGVsPgogICAgICAg ICA8dGlmZjpDb2xvclNwYWNlPjE8L3RpZmY6Q29sb3JTcGFjZT4KICAgICAgICAgPHRpZmY6WFJl c29sdXRpb24+NzIvMTwvdGlmZjpYUmVzb2x1dGlvbj4KICAgICAgICAgPHRpZmY6WVJlc29sdXRp b24+NzIvMTwvdGlmZjpZUmVzb2x1dGlvbj4KICAgICAgICAgPHRpZmY6UmVzb2x1dGlvblVuaXQ+ MjwvdGlmZjpSZXNvbHV0aW9uVW5pdD4KICAgICAgICAgPHRpZmY6Qml0c1BlclNhbXBsZT4KICAg ICAgICAgICAgPHJkZjpTZXE+CiAgICAgICAgICAgICAgIDxyZGY6bGk+ODwvcmRmOmxpPgogICAg ICAgICAgICAgICA8cmRmOmxpPjg8L3JkZjpsaT4KICAgICAgICAgICAgICAgPHJkZjpsaT44PC9y ZGY6bGk+CiAgICAgICAgICAgIDwvcmRmOlNlcT4KICAgICAgICAgPC90aWZmOkJpdHNQZXJTYW1w bGU+CiAgICAgIDwvcmRmOkRlc2NyaXB0aW9uPgogICA8L3JkZjpSREY+CjwveDp4bXBtZXRhPgog ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgIAogICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgCiAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAKICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIAogICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgIAogICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg CiAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAKICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIAogICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAg ICAgICAgICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgICAgICAgICAgICAgICAgCjw/eHBh Y2tldCBlbmQ9InciPz4B//79/Pv6+fj39vX08/Lx8O/u7ezr6uno5+bl5OPi4eDf3t3c29rZ2NfW 1dTT0tHQz87NzMvKycjHxsXEw8LBwL++vby7urm4t7a1tLOysbCvrq2sq6qpqKempaSjoqGgn56d nJuamZiXlpWUk5KRkI+OjYyLiomIh4aFhIOCgYB/fn18e3p5eHd2dXRzcnFwb25tbGtqaWhnZmVk Y2JhYF9eXVxbWllYV1ZVVFNSUVBPTk1MS0pJSEdGRURDQkFAPz49PDs6OTg3NjU0MzIxMC8uLSwr KikoJyYlJCMiISAfHh0cGxoZGBcWFRQTEhEQDw4NDAsKCQgHBgUEAwIBAAAh+QQAAAAAACwAAAAA 9QFLAAAH/4BLBIOEhYaHiImKi4yNjo+QkZKTlJWWl5iZmpucnZ6foISCTQilpqeoqaqrrK2ur7Cx srO0tba3uLm6u7y9vr/Apg7DxMXGx8jJysvFToMIANHS09TV1tfY2drb3N3e3+Dh4uPk5ebn6Onq 6+zSAu/w8fLz9PX29/EOz+38/f7/AAMKHEiwoMFt+BIqXGhPHwFoByNKnEixosWLGM0x3MgRn0OI GUOKHEmypMmTHVOqfPfxpMuXMGPKnKlt5bsZCU+QOKGyZTgTFkxwwzGAgVCaSJMqXSrTpgAYJO6d gDEABs+OPsGFGBBi24MBYEswHUu2rFmCTm9crYcC7AAUKf+zgjuq7SvYFWfz6t3Lt5tThRcGXOi5 7x+DARo89F3MuHFZjjlsRJ13g4RlEjdw/pWLjYWFB9gehLBggYVix6hTq57JMfCAeDNIwJBhY/YF GQN8rIW3OyFnaybAaqj2oARYEG4HgMBBd7Xz59AjciQxoAY8FDBqyIhx4Qa8HlVjxDsxwAbD39WC g522YQXiEB4YlFBsgqgGC9ZW4IjOv7//cTbFMIAMOeQwAA/y8ODDAOLBY0ODCqFXTQgMsCCNByCA wAIOHIAA2jQ0aKABAxtM4wFi/6Wo4orTMJTDbjnAEAN2NdRmg1rvnGBDW3DFVdg3HmgAAgchbMAA A11RU6H/BhyUKE0IH7Io5ZTOMXSBefBcoKUPPshwQQ4+1MDDBTyccEEMMshA2EPZmGAhexw0+UCG TA6AAw2nAbDhiftR6eefqjF0wlptXcDTBTP40IMAPoiHwm01zCCjj2xicxg1FmhAAwcl4DDkBiZw IB+noHHwAAcDRAnoqqyepZIPgwlwgg/v+JCZoQLMkGYPMMTKkYTRmJAnABtoYGeJK4jGAbEMKOZB CQwMacKRrVZr7VIc1faUdwL0wO0MhkaWgwyNMvgaVj9yQwNXwS4LAA1iedBkNCeuYOQAzV2r774k TWfeW+9g6W0Og3UZmwwo1DBADuhWms0GpQFAbTQ0JAlA/wk0ABACXhvEWQIIH2fM78gkX6QSgwEL 0NZrJIhZQ8JwCdjjRsBK8xUDAGhgsVHSdKzYChYgacGm8uFV8tFIF3QyogLEysMNMdSAKAlp3gTw r+leA7GF7EbjLg7NyqtxqheDADEIOCet9tr8qARVpLE+SsIMN8DAgw2xkkcpSNwMIBYAJhgNFn4W gAC0BVuVWGzabDfuODkqSXbDBTX0UMPcAkRdwwk9IChAyzdlt1DN1SCm2AP4vdtsCNLmvAII0qzA +OO0115TSjH0ekF2PEUdFQpjDgbeorJWNXrW2gxggZypA/CAfBs8z8EKnEpTgtFJmfDAA07a7n1M G1EOj/8MUV3Aa5rcCiA15TLAoJms73uEfDYM4BAfDfixIJ9QEA9gIQgWA4HI9GSB7l3oSAhM4JEs MCywKfBIfUJH4ZKTrPp874Il2QgJsKSy8lwpM5XBm8J8QAIewOAGBmIYzeaHjRBpbwBxYk40QsCB z4hFgNGwwADyNLhqRC9EbjlcCYxVlKN4QH/JqdCwynEYU83QWGjDoBRDEiAY9ICD8PABD0ggIATF Jn4RYuE0orQB5TAgU0TaAOtK4CQO0IB6GzDO7BigAVVRgyhgISOqTNez5BjQHDo0G3uMNbspGlIi TskdDGh1kzPdADfEWxPfrLGu5mWqRBxggbE0gIMobYX/BkMyjh21wQK3qKqMYJndHt3llRUQEUk+ BMsAbVaUQ9oSkSpR4awGdDcY4E0wKlwJ6Ur5JmIhp0MlsJAJRoNAEVkAYxoQCw6Gww27kG0a7gFL ng5TS23cq0LOcw8IhlXKa1JDVOAwQhFEsIMdiKAIQMgGEUZAzxFEAwk/EIE+hfADHXSjnva85bVW MoDJyKoHsLqAonojyXAEaQUswN4Y0anDeW2sG9a0ow7BUkxuFtKHqGJlNIyTGGls1GIg+ig2gBCE Arj0pS7dQTytIQKYAgAIMH2pTLMxAiHktABCCKhAV7WSHIDxL/Qg3TWClCGU6olEKwjRvMCRUUy5 pXke/9UGN+1YLOU4aaMilcYyuaGDIvz0p0LwJzVq+lKcntWlM6WGDnz61gIUYahERSo9ZmADGzB0 hQ4DR3sGV6Jnrc5YzaOqKa3KUWlkNTTHsYZxlEcxt/xNHGyt60uPUI3MFmAHmt2BWqWhgyO8NAhD AIIRPmBal4oAr3/SKz0EVFCbKJUaLLDYA7IpHOREM1/fqOo0Josvx6YyG5O97DS2opxgJQeA4RgC TD9A3ep6tgBDWOtZg8DOn/6AGnQtwHepYQTQFuADsKWSbOdxgjT99TxivAYdiYM/xC1RHMKNRle7 GY3HXgM5lCWOW47CTbdAtxtIyKkRiDCND/xUqAC4bv8QhCpdmL5WGkaIKYOtMYKXIiG9UlqviFkS X+AAtx35vZhwhuVfa1zVGsLdb3I4cF9rmDWnF46Gg3MqhGl4dgcf9jFMgzCN1o73Gjc+MohTNGIR 31Yc+lNucN1Cg+2BMpVLbHHpeijgPIp1j8npWjbMa+EGn3W0ns0uNdz6UmkQwaVEzkaGC5DjJf+n yet9cjiIOMpqGlg49euzlqkB4MTSUpvUYF2Yxczhs9Z5xzkVqmeNUI0O2zQaP3DpXbORYJfaWUV4 lq2ewbHHGntlsdsYNDbBEsExCucaik6OqQEwZxyb2bvS8CyEo6GDnEoD0pr19afvHGqkjvobQCmm Yr3/nOrjdgYsYc1hWLKx0btgA9gvffRZ0RsNXVtD2ADAdrA9PWz/TOcymfmcZSBED52QAAXBDGNg M5JiSzkbG3sEbr61wdz1XIPNZf71WY/s7WqAe8ciqK7CF17dcpt7IzeoDgpqk4OIEwg28A6dWi4H 2ElipN7yvfdSjSVRPcmSG8TtMwAsbWuBPzjXMN11NA7u0h47nFUdEUyuyiMAncMDTTfoa+bUJCtf ydvjFwG5NVSdQ/wEyW9O0mSAozEAbJyI2d/+qbZ/iuaYZ73N0bC0aG+e1434XOc+L16DoDK8d8Tb NyWWiNKrwXQAAE2/QywKcpJFDXNu2e/UuHHAdYxW/yG/VOYAADcAzMttbASZ7NHJ+WDaIp60C+gq WprKgGZ2vHl/HNVaFTk17kMND2zvj1SX8jTcgno3a30aFfY6zA//dXIT/rMbtsYHdgp56OScfGd6 R9rBoxktCYBgYGE33D1/kXL6jxtgvkYlvwGWE6un5NWIfUzVqoOWwlTNs3cp4hXf/ZgiPvaI731j JC+PtJOHWzLwnADqNoCjNiTuEcGjnbaBypNT4wHGonLXAG2ol02zJg2tdVrU5X2bNVrdJnvUoHgA QARkVgRG4E9E8AMMuGnqtxrsFw/DFzXAEynyJzPwxXwT8UNEhBifcWJHVGB3QRqkAWYCaA1CAkN0 Ef9HYOFU1zBX4yYCDviAtGdwlzYNRMCAbwV+HRgoHJF2wucranICKNAjO/IObfFeSYV/BBEfD3Qk PAgADtSFXXiA1WAvQCQqdFQUZEgNP0BmObUDSmZ44ld7BWANOrB7jpZ+S8gYHMEDVWFQfnggJCA+ 8kA1N5Aw8nd0fkIXnkEaIXBi26ADQCAErRUEQgAEQWiEAJWJKwdQcqZwP/B4e+iBGzGFU3gdpjiF bycrnEMCqyg/KDiKslh2xWZbWjiLuMhktegUx5aLvvgcu8iLt/iLxEiKwbgmT5AAyriMzNiMzviM 0BiN0jiN1FiN1niN2JiN2riN3NiN3viN4BiO4jj/juRYjst4jMI0CC0QAOzYju74jvAYj/I4j/RY j/Z4j/iYj/q4j/zYj/74jwAZkAI5kARZkAZ5kO2IAQq5kAzZkA75kBAZkRLJkEygjgh5kRiZkRq5 kRzZkR75kSAZkiJ5kC1gkSN5kiiZkiq5kizZki75kv9YkgSwjjBZkzZ5kziZkzq5kycpkzTJk0AZ lEI5lERZlCrpk/TYAR3QjhCwABHglADZAAvgjhHgAvT4lApQjy+Qle+oAAOAkB2wAAsAAfHolflI AS/wj2K5AB0QAQGgAFw5jwoglhTwjxDgAmIZl/UYlmK5lP2oAGkplu9IAWPZjgOglxzJl36pkYUZ /wBNaZSQ2Y5IOY8pIAHtmAITAAEDUJf7SAFWGQBS6Y4UYJnz2AEDUAHxGAEpwI4qkAHwaJYGiZkL kAGIyY6weY8ugJoQ4Jru+AJpSY8DkAELMAETEACCOY8LIAELkAKLuY+mqQLLuZrxmAKcyY4NIJVs 6Y8ZoALGOZXumAEDIJ0BcJha+ZsBSQHEKZa8aY9zeY+q+Y7k+ZZfGZmQOZnySAHxOQGrqQBuGQAU wJ/+SZZvyY4QwJm7WQH8KZX/2Y5cCQEKIKDtqAIqMAACSgEOepeHCQEFyo4RAJcdOp8dWp3/OADm +Zb9yZ9eGaIEaqEP6p8A2qFVmaHsSAEVQJszCv+g7kieECABc+md7fifAhqa/4ifzcmgXOmVLlCd QvqOMKoAdemg/emgBlqXx9mOEqACxcmO8fmfbtmkEFCjRyqi+lgB3PmOF7qiZ3qgAOqhTOmkMdqi Wnqk83mm9BmU9imP+umfmzmeWdkAE1ABExABEhoAL0CiAbCd7NgBEyABDUABfloBjKql8tkAqNmO EXCYE/CZDSABA5CbA9AAYdkAhCoBFVABLmCWo7mp4umPlAqh8XmYXnmdwTmqf/qpxBmoXkmjn+qX lTkBorqpFTAAzUmel9qj7giswnqoE1Cb+ZgClUqVpfqnoHma4rmk7uiVvjoAWLqoDsqoeboAolr/ paOKn5xJnn76px/KqR0gAb4aANHKrPWInxDKjhnAqBJglclJqhIAAYrKqOjppxLgluDppy8QrKBq mHI6qc9apzt5p9NZnM4ap4rqlpm6roc6qxKwmOBqndyZq+NpnAubqJYZsaAZqPLJjht7rwz6lRUw lSkKkF8anG75qnDZqfLpoBTqrsVZrGZ5m9Y5lS4QsMZJmlrqAh0AqN3ZjuvqlskZABHQAJ/an/so pHx5qKJarHx6rL56sCublZVJsVPploVqnOHqo4fKnRUgnYc5sQGQqZfqnaHpsX85nz+6py8QsAuQ sy1LthzKjhPQAYUKoT6btSe7ACHLsDrpsPAo/6+ZGqfJeZ3KqZmjWZn4KbUbC5reSZ5fqQDsWqJY ugATSpZCCpvgyrlSa5anKavwqo8vMAGuSbO3CauVupzWWbMne6xTCbozSrfjSaYuwLQ+qruOSbcK UAGiyo+tmajgWbKQO5XxaZ20+aApcJ0dQLrHK5URUK9gwbfiyqiGm6WHWa/NO55B6p0qIAGrmo+D e7l8ermhebmKChZieby2ybuEi6qdi7g8qbjw6Lo5274NAJctSqaWqa1lirLXm7lZOafgKaCXKpzJ aZWjO5/gOpqC+5UDsAACLLUAubHECqsD0KWwerzHGcA9a7/ve7w++7xJi8D125v2i49Be6Jf2f8A 0QugLLyk//mg1vuzzoqz3OujhSqWKbCnhzm9AgzEP6u0KruPl9qcisqhh+m+uSuq+NmnYrmwg/u3 IkugDay/iWuS9FiZzwrCSwmgeeua5/uZKFsBEPC0CvyxPCwBnMm2h4qao0vHTfmrbqyhZtmqESCm /OgCGlqjASABGbCbIJzI9fqWJAy3tuuVb9yONvyhhGy8OaqXVYqkXyqqHUABgnrA+hgBpZqWpjm0 WcmVJCq11rqyLoy5EqrIQdyOiOq3q3mYd3vGHxqhDRABEPACETABZtus9+rLD+q2GVCcVAyyOPuf GYyfv5vKFAqhw1nIrumknCvIYPyS/NuVyRr/pwFwtJ9al/hpyv9LoJDqqHH8lcPZuKy5noG7pOAZ qo5Zr39rltkrAYgckPWKyG7Zr0UMl+hLqnWpAI9cu/gMtebZusVZsP6cye6Yt25BqJCaAQK7qIns j7sJtWSKsot6vEXMxlA70a7Mt5jrqOjLzmVrpYuJmVkrzo16mwpAnLqqAhysjx0Ate2qABOqAlSa wP4JqYqsAntbsOMcABO6mE9JnBZtnMTJxttsk90c1VRd1VZ91VgNj1Od1Vzd1V791Tm51WA91mRd 1maNkTKZBAew1mzd1m791nAd13I913Rd13Z913id13q913zd137914Ad2II92IRd2IZ92Ih9OQBJ QABKYACO/diQHdmSPdmUXdmWfdmYndmavdmc3dme/dmgHdqiPdqkXdqmfdqondqqvdqPrQSBAAA7 ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/table-icon.gif R0lGODlhZABMAKIAADMzM8zMzJnM/5mZmWZmZv///wAAAAAAACH5BAAAAAAALAAAAABkAEwAAAP/ OLrc/jDKSassOOvNu/9gKI6dQp5oqqpmMRBBQAxyjMV1DN/vXdM+2SIHgwVuM9xghWoBnoOnFICR Rq3VaBX6zHIB1yl4C4YyTy0ZYU0L9Fzr3wxDI/DUSzhbEXvN2nRtcWckLYSHiImBioyNKQoCkZKT lJWWl5iZmpucloaOoKEbn6KljmkZRzgdR444O3atR7EFNq2KLUZru2saNb2MvMJqu8TAuHmmyoyk y85Mzc/SaAOd1tfY2dnR090g3N7ho8ni5Rzg5uG5wrwduxns8fLz9PX2x+NBOPusNumN6P5NC0ji nsGDCPF9ICjQGcOGyh6GSEixorwQEiGKyqgR2xTHjgDz0HN3zKJJhE3y7Ft5y1dLkCs+wkwkk8PJ mxUXkpv5rCbPMz414Ey4cefPiEaPlgqqNCWGkTZLDp0qzGktlqs4ZG06ginXrklVUB1br0TYr8zO oqWp9gTZt+10rl3adi7QunZjipxH0s5TuBeL6mPZ72XeDF4P50MEWKGpxIoR441caPLExnxPWaaM cTNnuZ8PrQu84d1fzAZFq8Tqb8NWzpApJ0ZtkYXn0Odu49Ywm/bUb7p3LxKul7hebciTK78WO/Lo Xu1M3zttmmdzxRaya9/OvbuCBAA7 ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcents/thinsp.gif R0lGODlhAwAIAIAAAP///wAAACH5BAEAAAAALAAAAAADAAgAQAIEhI+pVwA7 ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771920/bin/pone.0007752.g001.gif R0lGODlhZAAsAPcAAF1dXW9sb3t7e2hVarUCAboGAL4IAMMNAMgSAcQfFtQcAMomGckoF9k3G88u F+szAeQ6FuU9GeoxAs0vIe1LAeFPA/9BAfVEC/pdBfRSGPxhA/ttAvN6Af54AvRyGOpiF+ZMIf9t OtpSBp4jT6QpUZAbVqVJTapMVKVwUdNaTdNcUvJ1TddlXBP/DW78GhKdWxKdYCWdWCLrZSzmeBv1 aFH6U0PxfqyjOfePA9ywCfinAv+4AMCeLf+NOuWlH7LyLpv/APPbIvPVK+/3OuzlCZSaR/+uT/+P T6vxUfH4T//OTzECrywAtScAvikAulYfo0chukw3slMqql8ijx9OiiBPiSBPhTJPhSphk1RPkldQ kmhTi1h0nx4AzB8NzB0SzhkB0hID3RUI2Rgd1hoX0yMBwyAAySIexyERxhsq0CIyxgkC6gwH5xEJ 4g0c6gEe/ggJ7REk4wIi+Qc38zM68FIw000x0UU54BtIzhVJ1AdN8zlO+Q5j5wli7wJ1/Dpr/0tr 9mNV4ox22m2DkkaEqwLPqQjSrDL2kVLrqwqK7gqH6wOP+S+N/AKj/QCy/wWv0k+g/x3n7U/48E/K /42NjZeXl42Nj6eal7WXlJepmJy2nK+hnbChnpSZqZGQspyhsaurq6imprerqai5qLW0tLy8vLW0 uaWqu7ybqM+YjdSjlsCwrMems9GuvMu6tsuprueoovOUkavFq7bHtrTUtLn9vLvmu9PCvvn9ue34 ucr9uJeU1JWOyaOXy6Gc3KivxK2zxba7zLC005207ty6yOK+zMS56b3C077E2L7NwLzvwbre9MTE xMzMzMvby8PXxMXK2dPT09zc3NvJxeTIyubSy+zW0uza1/LZ1fDIzcvny9Tl1dbo2Njr2d743tjy 2Mb72/Ho2M3S48vS6dba6czT7//e6/nW5N7i7d7o4N7j9t7x4OTk5Ozs7OTo6//q5f/g7Pzp5ub5 6Or66uT05fny7uvu9uXr/urv/+Pn9u30+vT09P/19PH1//////T89iH5BAAAAAAALAAAAABkACwA AAj+AP0JHEiwoMGDCBMaZKewocOHBPdVgkixokBmpSxqpMhwo8eD+9p9HEmypMmG/Br+O8ky4b56 7eqVM0azpk1j4L7V2llLWS1d4HAJHSo0F65cuqolrIbtGjZr2J4+tXbNmtWr7bJq3cqVq7SH0pox Y2aHidmzZ8nMWTSjkNtChuIe2qGjrl27OXLwSHjtnd+/gKtdEnVr07R3HkU6bEcuWqk9ayJLjgxn ziMmbdA6cdKEB4YHoEM/kEC6wo+UB/sCXr0KE4BLm6gh3qhYoTlqxYi1ulOmd5MyXZp08aKmEZM4 mst4uWGhAYMEC6JLb1AhyMqC0tpZAxzvnatLlN7+YcuGCVW2WNlS/pvHvr37eevdd1PIEJ45c8RQ 2dmM9qwaP04gZ5YTTAjH3AIGFEDAggw2QEEQB9njj2p+dbcaNphcogos2QhEzyzNPOPMNqOMEooz 7ckjX0L/gPKPfeYUw0odmxHIhI1MqLHIcfyZZaAFDCjIYIMP8uVXNa4c5pc1l1iDCSWiTNOdQN0k 48wz23Tz3pbzcJNQP6D4c5852cyIY3//BVgjZ8Dd8MACQw4JQZEIqWZVNX5dcwuefolySSgCteMK PaPMYqiWXLbnJULp3NLPfbnpdyZaacZR441NgHFgnAzOCSELC6hgCSXNCEQhYK64wmc9/vDjqqv+ +/yTJTf0rJOooglFQ4qY5pzTyoz9UepHE5au2aYFcMapoKf+rOCACszsamqfm4QTT1XvWLjaX/Wk eCuuCEnj4pjUABusWf8Ru6YTxybAqYIRFLnCBStYE41iFE7DiSiruALYLaGAQoooomxyyT7fbrko Qv88SgwxrJh7bqVr/ibGgUIyCK+8FoQwkDT7sPPqyCOvBLDA3Cb83sIJ9XrOw3X0t4R/AMbR22bC afpmxgsmGC+ERzzgsUD7+FPbQP/so7RC8W25TSYoytOOPPKw3JBjd/zWBGdbN9HEf2Lo0cbYZLtx gwQRpA1B2myDoAHQGPRQUG2lVMJOO6WUwgz+04mqOI83tjijyzfKQLTPWFxQYYUVVVRBxeNUYEEI HH3E4cbll8+BgggcdO45Bx1wgEMOSPhjRAdyE3Q0O8woXTTD/zT9njaZyKMNLbLknolD9HzzjCyz cLE441UwvvgVW6BwwggjkOA8CSVMwUUW1FOvRRZaaLEFFzbwo4QORhQUDTMdCUQKKaV8ZZA8zoz4 zCiVGEqLe1TXP882DnmjTe6yRLHEzOdaQgcygIADGBABCHyCHNgABjM40IG9KQMeZuC9HQihIOyQ BjtexztDiWge9OjGKDIBtXlsghajcA/+ELKPMHnjG9rYXxQwtS4CCTADBszhARSgQDOUgTP+l9rM BP+RBCIMYSCxkgYzBHa0ghwOaf0QiOz8Ng+qqZBFoNjHC2/Xv3PZaAkbyEDGCpBAOQRnXTdiAh5o 4I8iHlEg0QiZQa4TkWggpIpTs6L92rNCkJTKG4CcRRcDyAQwilFjB0CAAsuwNQL1SI0y8AcSgPCD dnCwNroCVEVUxp4+GkQaGXnhNmZBC/+hBYBnGWDGDJDIRTbyUmZZ4z+Q4AIXWEKT/kAHNKCRD3zg ox9RzBUoQKGY+82CHlRUmEuk8Q/9PYMWmphhsGb2Pw6IUUEFKEAr3+DDGm3tLLKsQQtqUBBdWqIT 6AiGOIIJkXl04xnIrJ88qeZJhHhDHt/+yF0UzhREJuAABAtgwAIc4IAGNCAKehgDGb7AUIZ64Qte wAM5D0GDQxSEHP3wpTiggdGWBMpwzEjGHvhA0pKStA988EJeMMBSDWBAAx1A6BgYutCGksELeUCE PyQRCUmU05f4gEYwfAlMfQDzqCNpItOIUYlBOPWpT+WCFgKAAhNY9aon2IIc4jCGrnq1q3nIwx/+ wdNIIPEf5IAGMDrxiXwcwxLAyCg0jnEMaIgjqQ4BZj6g8YseeOCvgP3rBz4AAT2UgZpoKUIfFJGI xjq2sY9QBB38MQlHTOJj+yDHPX7py3vcQxy/6IQ4RisOcuCVaZ69hzpOoQJOMYgBGGj+xBk0Y5YX NMGLTAgDGKDgD0j4gREXBapwh5uP4sbquK5DbnJdl7SQNXe5UvSHZ9VRjmCkwLULYoAGZGuWmdkI Brc9V2536w9A6OEPBXEHUMlBjmB0IhjHAKqEAsWOaGhQGvi1bzOiwV9p8Pe/AN7vf4vWwn9MFxnA aC12tctdANroBfxEi255C4g37CG4vvzFJ9QxXHyEbCzuqI1E/EEJf1jCaHaL7kBKAQA6Js0fLZSu Z4Pxi+vy7LXbna2DzQKDSUl4t/8IBBwmSxB0ADUfndhlJ+LrS3tYch/SSIdW3JGdDd6NHaC4Vzvs q5VoEFMrzBAJO5qxj9SKQxjXXbD+Bhwx27N818dnmbA/AgGGO/wUqPdIKy/lO75o3M0VAaiE3SqR nXZUgnwCIwUlTCEA17EjAAEAACkEIOYwpXYcCcYuARiwAe66ubZwNosYyCuIOggiFGLeh5GJSg66 crQTncCHhLKSQXTcLcTja0cz7tYOkNXXzyHJoH+r3I5+OIMYZb6HWhN849d+oMEDKqRtxTte3gqE H9nxB8jI0eEOS+huSsvKS4IdkidvMCTXcIc99pHre7FbJCEx8D3yMY5gKFhjr42tjvsD4WDxR84I WXW3j2yPgudjuQhPeKyejHCCpFatKbixkBygb9ou4QVlwC3ADyLwblO3HCAvxz332FkRpRbkH/jw LF9VIJ3oMODlCWiABhbR5k/HwIcRjGAXutCGMFib4wNP+TKGYYxfCEMY6iA5RUzOwn28IhWwUEUq pD71qatiGLzwRC96ofWtz2IXvtiF2HkRdrHvguwJQYc70IEOcqx97Wx3h9vZHvd28Lord98KO8oH EccQYyy6SgYxmtGMZIjFFWJhRjNKEY1mkCKkprgFKZKRjGAQXvEO+YfJlzY3DiJt855/iNLm0RjN t8Md/viHO9htjzD/g7+Kv4bRQOZff8CEdXZsSK/nuEGDZMUgITnI3T4SeuwQbcwcNC2Mj8+M3Hv0 +R7lOxKL74+AAAA7 ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771920/bin/pone.0007752.g002.gif R0lGODlhZAA7APcAAHpud2kjdLorK7EQEtcMDOsFBfYAAP0DA/kKCvwWFu4WF+smJ/wrK/klJvw0 NPo6POQ2NuUgJ+szRcY5cKxRWLZZZLRtcdJMTv1MTPxERP1TU/xaW+dOU+9baNNtbvxkZPtpavt3 eOxrdOJYZZQ/ZkaqAFSqGG+pKAD2AAH+ARj0GCH1IVnVWGnLS1nZb2TlakXdN/a7Auu0GOi6KOuW CfzACfTEMfHNXZ+mZm1qt2BduTk5+isp+R4f+UI683FxzkdH+VlZ+1JL9mtc7Gtr/GVk+3R0/Ht7 /Hl1+HJs9WBM1rZvtqNfmtRvket4is14qcpajpVz14l77oJ796dzyao/kADFknnflAGs6gCw8CG0 6mXG6UCey5eXmI6NjrCNkZiapZiUtYuItaqTrJeorKeop7enqKq1qqaptbS0tLu7u7e2ta+yuaq2 lM2NjfyHiOeFmfaMlPyTk/ybm/WTluaOktWKsueMo/Wco+mZrcq9vcS3t9OxsumoqPykpfmoq+qm uPattOi2uPyzs/y8vPW3vNeolJHukbvEu77KvrXDtbDOsKLsoq3ysJvTlvHZjuvapfHZrvPirZCP zrSQ1be8w66uz4OD/YuL/YqF94+Q/JSU/Zyc/JqT9pWK8KOa9aqV56yp6rml6aSk/Kur/Kul97Ot 9rOz/Ly7/Lu297G065Wv182ZyNqlyMqn2dSp09e32MqyzeSrxeq1yPa8xOS91sSr5Mq26da95MS9 97zByrzAxrjK2LLP85nZ8cPDw8LLwszMzMfEyNXIyMbRxsvVy8bL1NjF183S28ja2NTU1Nzc3NTY 1ubHyf3DxP3MzPfGyujF2fTM1OPV1erY2fXU3Pzb3PvV1tvm29Lx0/Plz9jG69jX58TD/MzL/MrF +NTM9dTT/Nvb/NrV9sfN6uTK4+jV6vXc5ePZ89vi6tDn9OPk4+zs7Ojm5fzj5f7s7PXm6e377ej1 6OTj/Ozq/Onp9/Xq8+zz/unx+vX19f/y8vL88vL3//////f6//zw7yH5BAAAAAAALAAAAABkADsA AAj+APsJHEiwoMGDCBMqXMhw4TpzDSNKnEixYj817AQGQyQwnzCLIEOKRPhrnUA1wTqWGcmyJcN8 /ZQN7LJM4DJg7JgpS6PPpc+fArv0EyqwTDuBwoItw2gGqFOW+br489KvTL4yJvulCRZMTTo2T8OC nNqPaperGS+mWVrszEA1MMXKVRi17FB2XtoJW9ZVmZl1VIvOHYwwn5d8APqBwctuDddgwNawK8Mu mGHCmAm2cyvUKmVhjpX9CoatqVCimTHjjUcVQL41fNmBWbZmrzK8Q1NnXuaFHYB9aa62C7aujDI1 jtXkTqMb89KrQ/OBaaeGNmQ1v8C8ttvP38B93X3++lOmjCt5ZjrJq5fpst0a6HrWIaq8To0yYb9o L7u9pp+8/9ksckYiiiRjShBEGFFEEUdwwkkqpmiSSSmcHBHEKZcYEQQPRsDxCjjDTBIBARFwwIEH dQzDjSDNcHCBBdycMs4/7vwTjimcjJJKEKnYE04vo3BCSi6bLEjEEZmI0IIKjfQDE0yBJOCAkx1R +WQ8/8mTSCLMJJLOKUA8YUspm4wSzhNOtNLLJUdgckQRmRhBxIKX3AHNOJYgs4EITmCQAAMZxIHO Nn9k4MAF47RyTDRzXAOOg6icUoQp6IBTziiYkoJKEUEgaAQrLaDAyD7s5FNqHwYsYGo+q5Zaaj7+ 8azBjDyIrFEMMdyQEoQfuHyDyij+3AEFK7lgMsUlm2CCIBFEIMsKIK1MUscHcMChAQYSSAAHOk/g IcIHHvRSCCyw+OEMOKakgs4pm5wSDjrnoELKvN4YcUkmSFBRiguituoPqqq+WiokjxSsTTxnFLMP NmcMuMolRNjTSSmnYJLPKEkkYcoUm5R5Cg9FMMtxERV0YAkBEmzwAQjWDPLKLeUgcI444vwSyjbk eEPPNeHU80683nQDzjno5NJNLqecwgk44ICCwScurMDIqvJkY0iqq646QwwyyPBIPIgwsw/CwJyR DClFkALILN2MYo090ESiDzrhsKvJEZd4o4/+Nd5o4sorPyATByHPzOHMFBM4IMcH5cg7CTUNfMAK Jpt0M48+55BCRxSaiDOKOOdsc8qvsrTSiRGYhEMleIekUMIBDFBJpQ01SNKPPvEogs0+wCSCDTGr HAFED0L44AOcO/AwBD/dMEhEDzsQAQQP0fMAiihKhEJLNK188IYUrNByDh72oILJD6FQIkomQHjj DcSbkCIKEEnM02aRQNhjhPEabhJ1I/k4CjashjWB5WNrkMiHPBCGpUQQAxvFUIWFpJCJIgihCKmo oBSkYQdPdMITTLiEsZKAoCSUIhWTCAUeXlEuVriiCU5wxhv+0Q1O/OATrLgFJ4gwD29YaBP+priF EILQCyMcKwlDmEMSqKcgVPCLEf5wVT6kQQc8ZK1UNohBAmHlBWVoCRHKIEYvNFGEd3RjE3hDRz26 IQpAvAEW3XDFHcAxiltsI0NIO4UlYnEHV2xDGpyYhQhGEIcmlKMXpEihHV4xCiTQwxucQNYpbDGE ImziWJeYQhImkAQgBOESeXsBCq7gi3Ssihp/6AOp/LGqG9xAEqaKBzHksY9ilOEMirCEhPxhhAsq LRzdSNoz3AGOSGGCE984xQU/gcgf9KETn3CFE4jQgSVQoQOYwMQnbEiOI2zCCD0IR9BGMQVlHmkK nTiSEYAABCFcQhMc4wS/rICFLfSjHfH+6MMBAsYqV/1DHqyKRzzGxoxbIkIV3bjdJVBBj250g2jd SMUgtmGOxuVjXt1ABypyQYpMCKEZ83KFH1BRDVHYghDW6Ac6vGGJVIziFN4IxybE6Y15hEMc4ciF KDZwi1z04lfzOIctPIEHfbwgBfTEAhas4LoDGOAACKjS1my3j7E1UBHMiKAq3mGNTtzCHfSAhzvs QTdzeKMW0phHKspRi3KsdBRPyAM5whAGMYRhDDoQwxi+8AUBjAENkwhDNWKai0/MQxzm2EYq+CGN c4wjFbWoBzi8MQ5z0KIa6BjHM/xgBkeQYRWfJYMj2vAFN7jhC8IARix+gUBWDSQfxNj+Q1ZzUYpt bKMUudhGLnIBDqT9dJKuyMWkXIGLdXGCCk+YgzfuEFdpfCIXuIjGIEYgDUA4IQ7PyAVOTcEzWcii G+GohjVoAYd6zMEV3YDHNQZxDcfOQQM4YMEisooMR7jgBcUIxnmyqozWskMf7/jHP6axhz0Mgxyj EMVGbxEKTVziFHdLloM+0YkdaDO3oCDFJ5YggXBwIAMimAXdvAELQJwCGm/IgARoIQpwmCMSFOhC BSrQBSZ8oQkUEEBfSWBjC3zBAxYYgwYYcIJRqkMd+zgECmBAi1k4IxJHbsc+bmCDSLDqHdNoxznM UIZh7KEc5xiEPtwxiEDY77DsEiH+KbbhjH/kohy0kENR+9HQXHBidKZwxju8YQcN6GMQ5cAHP7wR iHLkgQMQCMQbNpCBB2iAAwz4kwMY0AAEHAAEGlgAARgwiKNaIQu+8EfrXleAAxQgC1nAh5Wc9I41 TGPAaTCDHo6BizlYww9vmKMCqDCKXIRjFOiwxzn84A5TnAIXkaDFMwbhBzxw9BS3eIY+CBENdLyD sc5wBjRIag5zCMIN7IiDAxCQAG34YQ6EwAADNAACEGyg3SPwgAPOcVRG4KNUSi6BAUpdAKWmwx9b i8Q/4vEOPUwDHsMw+DCcIIJngCMQdrBDHu6Ai1rgAsKp8EY5oHEOi5cD3RWtBSH+5tGNJ0BhCOcg BC1skYl5fEAOKi+HPfLxDBEYomUhGPcgQhACQsxBDiH4gBNoEQIMnEgO6BDl1PCNAn0XYN++8AU7 +AEJSbgSEu8wwzDcoQc9JBwOIuAZNG5xCz904xa2oEQkTbFbiuKhrYEYBC1kUQtz6GMed6iCEmrB QldkAhUf8AMt/FCOPlTjGXVwwxtCAIIHJOADGNjAuYH+gRDwQw4i8IAhIvGEUDECS/nI9773DRN2 kIofj3jlO9IAj3YUeBjDINcg4FEOc7jjGamQQhI4dolyiA63cZDF0ORAByfcAR3WmBss8nCKTIzC G+2YQjRwbosGxMEdx7hApcn+7ScHsFsDDvjABzZgjUDIwhJ88IMCijy1dKTjCk3fdwJUtQ9pWEPK rnpHXtpRBq3rAQQfgA4JgAEY4AAJ4AchQAezkDTfUA9k9gbmUA1y4AAHQAmbIArPYA3jwFGVcwRG MArzoAmc0AQbEAIHIAEN0AAcQADR4AQZEALuEAlOQIEOYIAHcIMNwAAS4Ab6IAee1w9bkAVM9Tqx ExeWBg1W8g5dMAz6QA174HWwcAvWQAhR4AqwEAWhAAd3QgqXEA6pUAq28Aa3JQph5gBLsAQPoA9p 4g254A0SoAANIAH0MA8i4AAb8Aob8AR3IAJuAA50UHmDwAAgkAetsAFyMAv+tRAJIZAATmAJYxAC sKB0pqIOV+A6+6YAC6AFWqAM19AOraKETEhgsTANtnAK5zAESCIFRKAJUSAKv4YsIpgLciAKqYAL gQAKHkIJVTAPS0AJuPBddNAEUAAF3UAPrPAES9ANYyAKdjACFzACTLAEO4cBcpAHIiCIrQAO1iAH cOAKYzABS2AKT7Qqo2ZqB0AA/sYPrsJK78AH2uAOzcAHfKAHrEAJ4AAEn+AJUyAFnyAEpBAOkZQJ nvB8gfBc0XAHUmAO6JAKnjAPm0AJrLAE4RAOqMAJU8AJFPkJn1BDqQAIIjAAAxAAOmAGAkABTeAB ICkATAAGZmABdUUCEyD+BZTAAqJCKvnACCxwAqNXAFuwBaYkRRnhD0LJDpVgDJXgARSQA2QQa1/A B2hgBnsQBjmgA2NABTkQBmgQBWIgBtFWCLWADtfAPE5QBTzQD/NyCUDQMaewDefgDacgC3+ABzQj DdfADs6QC3nwB5kDD9JACIFwCqTADfZgD+6QASeQAkunQPmAKk+nAP1kKlFkKvcwmelABmhglJOw BA3gDjYFDvTwCdHwDOdQD08Wd4SwMiBwASLQC3cmDv6QCmXSCzVEOcKTKaQwCmc0L5jQhXXDCaiA CjaFm5yQC8hnDe7gDn4AAqjQDfXmJKzUD4FwAA0gO6VnJfdQD4KWDrr+YAzIEAasoAHQYA+0UAjn IAGE4Ax/IAeDQDibFQmb5QaCYA/lAAiyAEya8AmAOQrgkAqcsAnRcGfygiGl8CtEgFOnMAqo0C5K k6CkcAqfkAr1YA/OEAJOkAq8kA27I0XUEAmRQA8GRGVWxg73oAbIgA/GsAvGYAxoMAt/AAvPoHLX wDLOMAch8Abq+aLoKQceMAzW8AytwAp0s5yo0AneoArJNAW4UAq3iUOi0Iab4g2RkjSiQCYiKIKk YApApHGAsASl8JOR+V8RKkWrknrawCr3sAbIUA8pmgy68AXsdQp5EAnXQAvGOQhysDiGSAvX4Acf oAEjIAh/8Ayi8An+1oAO6CAOFUMPR/CbliQKpkBhjWJx4BAE3fCb3zAK0sCfDrYJpQBeR+AJn7AN 0dAg4OAvQHlFkIkPZloJy8AP9cAGxsAGFWCIquAEgVAozuAHcfAGc7BofjCFfqABGoAicuAOpwAK 7EUxm1CgmLBRIpQHcIQK+qAPi2cOR+AN4kAP90AK43AP4kAKGFkP5nAKRqBshIAHUIoOq/Ykq7au TnIPlYAP6VAJbIAMu0ABD8AAlgZVCeAM+nqDCQBVCDCwCYAABAABBuAAT+AKclBTODUO7vBSNZUK uSAvnsAAoAAOz/AH2EoP4KCgtWAN8+Aus+AHfnAOzxAHPIcK4aD+dPuwBfW0D32AAPzEDwqAADSg RZLpBSW6C7vADW1aCIGgAflqh9dSgLAzZAcwgAR4AXXQB9niBNGgM3XzCWJoDoHQAXdAMd3gDU+w DQ5YDnPohe2yW9/QDbeJC7VHmNLwCq+wUk/kD8nQC+SwmPsUmYv5BzKgs/lwD2WQDCbKC8xgDF9A B4EgB9fiPSCweB+QARlAtIAyfiDgAX0gDSCQASAgC0GTC6MgBSFwDu5QCCIgB7ewnG5JD+IaDfmA U1AqI73VoKcAC9FAcvoQDbCgN6dwBfKFDcqwH8vABxfgAdPQu7w7Da3Vt13ADfxwD7uADLqArx/g DB0QAnLwBmH+dm7B6gAP8HKYFgJuUAeAMHFO4AThcAmkwJB3YA/1MCjSYA4cNSTuAwt2AF704A/z gArjcA6Pgq2AEAj1wAn28AeAEA76MAqWoAZpgMAKnMAMrAYIvAb+dQ9sUA/8gAyWuQtiIAomewuv 4Azu4A0zNw/bgAGD8AfEFg54EAl8AAijwCxt0g2YkAvjVQTzMApR8AefED+32Q1EsJvRkwskZ75B gCkitE1Dkl4+kmfdwAt6sAa/gB1qsAdOrAaI4MCxQMVT9a7Lyw66UAnO+wXQ8A7vQA/jAAtyIA6f QArfcGsR+AyiiQe0EAuTcAcK6Q2mAA/j4A1MMwU29ajIgpv+6AAN5lAPI0upXbsu6FCpFcO63fAJ 38CGpSAFpOACKsAI7LAO7HAIKmACCtDJC8AO8tAO7HC8k3kP+MAN3KAO6YAGXQAGZVAGZAAGX9DK YgAGXdDKtlwGtgwGYGAJgnAO9sANvEAMzJAMycALlpANx4zMvGDM2dAM7fAP63AMlCAMsHAM0xAL 1HAM12wJzRANx3AMscDNx8ALoUAOjXAI2bAq2XAIjhAHcUAHdMAqrEIwZeodB4EMKnqZyKDPaFAJ w6wLaKALuiAMbFAJlaALbJAGigAMwbAGinAGvUMMi5AGiFA2wLAIu0AMu6AIDhwMwgB7a5BwegCV r1dga1D+0lr3hMKAEvZQEOAhEuTgvGTABihKrz7LBge9nV18mbtgCZWwBuUhDIjQBg3dOwmzJYmA Sw+01EnxC3rwhF62ByYd1bKWcMOgdcrAB7+AH2nhE87L08gAtGiQDNyADwrNnZUgDPzgD/wwD4hQ E+wADGlwBvJQDIlQDG2ACBC0C+2gCFuiCGzwGNMwDV42DNMQ1V62BtRgcAbmdQS2CwkcFz5xD/xw 2ZeND7wQr5ftD8jAD+mADG6d2SnRD0RZDMCwD12SBgO1D/KgBvsA2LK9DrfxDvqQ2HowrYidcP8w rb49DNUwvHoQDEfxE5aN2ZfNDLqA3G0tr5htyjUhEPr6sDsLAwwLVFXYkAj7wNHAAAzYMBC/zYT6 AA/60A7i7dv6oAfwQA3FgBKU7RKTydygLWjyjdyqRhBjszDUXVXxsDvMANhuMRC93YTtgN4G7tt6 QA3UoAxncBtAYdmjLd8RLt/3/R3YnQ5VleEaPjYEYdv6AHsHfuDD8A7U0A69i8+VLd/JoAYE7X7r QMHIbcowreEF1QZ53d0ZLg8EMeDt4A7TugZ7EGvkMQ3UgN7vIBbHjdwnygZkYJRqwAYUDtOtvQ/t MEvJUAzFIDZjo+PgfeAFJtVYbeRIXspkXuZmPpkVPhACNVBszuZWJVAEAWBiPOd0Xud03hIBAQA7 ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771920/bin/pone.0007752.g003.gif R0lGODlhZABEAPf1AEZGRk5OTlBQUFtbW1xcXGBgYGNjY2VlZWZmZmdnZ2hoaGlpaWpqanBwcHFx cXJycnNzc3R0dHV1dXh4eHl5eXp6ent7e3x8fH19fX5+fn9/f/9ERP9kZP9lZf9nZ/9oaP9sbP9w cP95ef96ev99fWyn/3Cp/3at/3yw/4CAgIKCgoODg4SEhIWFhYeHh4iIiImJiYqKiouLi4yMjI2N jY6Ojo+Pj5CQkJGRkZKSkpSUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGh oaKioqOjo6SkpKWlpaampqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0 tLW1tba2tre3t7i4uLm5ubq6uru7u7y8vL29vb6+vr+/v/+Cgv+EhP+Hh/+IiP+Kiv+Li/+MjP+N jf+Ojv+Pj/+Skv+Tk/+UlP+Vlf+Xl/+YmP+Zmf+amv+jo/+np/+qqv+srP+trf+urv+0tP+5uf+6 uv+9vf++voe3/427/4+8/5C9/5S//53E/57F/6LH/6bJ/7fU/8DAwMHBwcLCwsPDw8TExMXFxcbG xsfHx8jIyMnJycrKysvLy8zMzM3Nzc7OztDQ0NHR0dLS0tPT09TU1NXV1dbW1tjY2NnZ2dra2tvb 29zc3N3d3d7e3t/f3//Bwf/Cwv/Dw//Fxf/Jyf/Ozv/Pz//T0//U1P/V1f/W1v/Y2P/a2v/f38Ha /9zq/+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7//j4//m 5v/p6f/r6//t7f/v7+Ht/+Tv/+rz/+70/+71//Dw8PHx8fLy8vPz8/T09PX19fb29vf39//w8P/x 8f/z8//09PD2//L3//f6//j4+Pn5+fr6+vv7+//5+f/6+v/7+/v9//z8/P39/f/8/P/9/fz9//7+ /v/+/v7//////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAALAAAAABkAEQA AAj+AOsJHEiwoMGDCBMqXMiwocOHCWvlccaHjpp6JOyAoLNRxJ84EEOKHOmQTpw8etS4+eaGBBoO aECoCQeSpM2G2Foo0RSDlI0iSmwEE0nnj0BmsmzBcsbqm6Bvr+rZepiKWypIYuqRurkwmIApFTxZ CTDFQIWsXNPWi6HDxoApWySoRRjMwBcNRipUqFehyCSF5o4VE3ysMDeH2AoXHnwM4c8KCTzxnYuQ 1C5zngLXK7b5IDfB2A5mM4wwcTFzBwmjHijKXCVNAmFTtsmt2GGGtbMRVHZs9cLEvmfPtR3yc73a wXE2Fp5WM8lgnElGZ07SXGiS2Lhlt9mbukjrNrH+reaWHOJy7w/Pi9ROsDtJ9egVwg85f775+Au5 3R5pHzz28vgNNN131xlkX3oBHiQedwRBsJdA/vGXoIEJ+QZgPeoZMZSACmlCgCYD7NfehAQNSNAk CeiQwBYGzKcfQUoUdKBA3LTgRAJbUUjicSIWpJcNqcRwkIkGRWjQJClAokGBI+5IJEFTVKLDFBLU x9CTDr1I4owNLWeaYoOFxuWVO465UCqFARgYKUzSVyZ2x2wonznFtOmQmbPhWVBgqJm5HJ8hYemd oAixJ5CZA26HIImEGmTooQzBpyhDC77ZkJYDwUdKKgRhOpCnCemZZ0NGZkpQBV80aVCl8u0IaaT+ CKknRqqmxrpQqQniWhCrMvr26KRF2qmqq2MSemCxrboKobAC8VrPF381Wx55BNkwxZ7Mikqds7US VMS13UIInyc/6FgQqMoea1AlW8g4rEAAGGEQkbqmu+qF2L5Kapva4meiqIH1e55zyoa6H8CD4Zta s8wW3Gl0eh5zXWLp0amww+0VIydCdM5XTKP1YMMmxiHtolh3gTHWMIaKXfeZYsYhpEs95EgzISv1 PFMLLss48w0r6ugbcp0jpdyjeuMQwkgiiJygiyGGoPcNGnzYQYcZtsShkhsiwLJBLUJTp940JgyS iCIl5HIIClJz4EYefHDwhx1muBGHH4JwgHP+PfWqxSs1iwxEzTjsjCO1HwOpE7Ti9SxeInogk7yw d/1KzvfKA+1SwSQMIHax5ZMvVIwEWzCAZ+Wg900QDnH1qODnoL9OmeqxJ6sW6rULFDmsuTN40+69 GzxSzMHfhNxDgblePHbEKYQN0cvPFvDJ1Csf/fXYZ6/99jb9EMMkLYgxSQw8/VBEDKlY4YknSsQg GUKTkFLJLsdZkVgw4sWJv2DBVMLpFtzYxS6MEED+QSIVVdlFbeJEP+EwAAItmIReNDGFryRAAmJI QQyMAIEUlAshW9iCEpwQwh9MwQlO+AIkKvADI+BAB0Uogg0qEIMicOMHNoBAEVKgBCu0oAjurJNA D5Ugig0yRwLYsEIFNNCCH+ilHhKYAg4MMAAjSOB8CdGEObYwhVSQQgmVwMoklDAFT2gijJrQhBim oAkjmIOEW2CXJyAxhUlUIoXyE0MwviCb2RzGOfQ7zGEaox/icQ9jYtgCKZwgBiV8wQhKaIwSRqi+ FJJwhHVCoDl0QAojWGEXWxBMPZxwDCtAIlrRs4IVvpAKI+hASjFAjQmdUA8bkKIIP5BSC8xhhSnE KCgxaJcVjFCEZ3HDCpWQ1/XEQootiEEU9RDFLioRzXpUwgrF+MIXoCkK6IgCEpIRRRgFAk2BkAIz nkDlIeMTEAA7 ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771920/bin/pone.0007752.g004.gif R0lGODlhZABCAPcAAGUdc3s6dnMXVIwAAIwJCZQAAJMLC4wUFIkcHZIREYoaIJQkJJIrK6A+Ppp7 N45oMok+Zo9AQJxCQpxZWZdAVKZFRadcXJ99Vp1tbaxsbKZnZ6x7e6Z2d7h2drN9fYdKbHSqdGiU dZ+APKmKRqyMSZiQaKKacoayfsasf18qkXlMgmdsv1ZQ2mVY2F1n0nxr2Hh4ylxg5Hd3+Whq8Zdy mKF8k4t2tZFzsoZ+24h/6m+Pk32ogm6Jo5aWlpycnIyMjKuDg6iIiLWCgrqFhb2Li7GKjqeHl6uX mrOSkr2UlLubm7SamqWQi4KtgoaiiYWzhYi3iI27jZSqk5momJK+kp6ynr2zjbaslZ2Eo4ibrYie vpyYt5SRs7CRqI6hs5uuv5WktqSkpKWqpaysq6ykp7WkpLmlpbSrq7uqqq2yrKi3p7KwrrC8r6el vLO0s7qzsru7u7e6tai7ssKOjsWSksqVlcSbm86amtGdncm/mMq3ksWiosurq9Whodqlpdaqqt2p qcO2tsO9vc25udiwsNW1t8OiseKtrfqmpv6qquaxsey2tu65ufK8vP+9vZXClZnEmZzLnKLOoqvE q6TEpKTTpKrUqqzbrLTKtL3EvL/Lv7bGtrHdsbbStq/GsLXjtbjnuLzrvL/1v87EncDGvpSHypeb x5CVzKqe2o6hwZyvwJeoyJ6xwpG6yrWtxaK1xaS3yKa5yqq9zrW2x6u/06S31ray2KGk1oaI6ZaV 5Zyc/o2N/re16Kyx9se3zbHE1bbJ27nM3rbF2qzC47fL5L7R47vR6cTExMbKxsvLy8vCwtPExNrO ztXLy83TzcjR2dTU1Nvb29XU19bP3vbBwfvExP/NzeLc3Onc3OLV1e3TzMPzw871zs//z9ni2dD/ 0M7hzsjG58DT5cbZ68fa7NnY7czN/sjH+cve8cLb/8ba+NjY/s/i9M7h/9Hk9tHm/tjn/9bp/Nns /+Xl5evl5evr6+bo6fHv7//l5ej36Obn/Onx//Pz8/P0/vT4/////yH5BAAAAAAALAAAAABkAEIA AAj+AP8JHEiwoMGDA+/x+2fv30J/DgUuREixosWLGDNShAYnjI84PtyciSNmjBsfYxpqXMmypUuH /GLG/OdP5sSXFSHSLKgTJ5k0x+K4GZMMjr1o0KIJinYMWrKbA/kplBqNXz2oBueNeZOs3jykyexB a+YsGsV6btaIOQMHmlNoyI7BEXTM5bxyTKXNS1bW7dtjfA8eCxNmcLIzKOdRtHcsmmO3TZNlghZH MUJ+SKXZs0dP2mNpZVWy3GcsnenTqFPDy1qP4L17B/OJmk279rbZt2uL2qbHke/fwIMLF26tIrx3 8uTFk+eOnfPnzosFG/Y4mudo1+jZm7d587zv4D/+hRpPnnylS+jRW0qP3oEfP4cYLZq/iJF8+/UZ KaJmrVo1a/0BWE0iFcWDXHLyFOPOgs0xuKA6/HyFF3bOdLdZawZt882GHH7TTTegfCjiiN18QwKA AaZYjSLz3beIIvLV9+J/1hBI0XEIyjPOcjnmmM4/lkVFj1uaRWPPNc5AM89C3JAo4jehdOikif1V Ix8e8M0H43vvxeifNYfQV6Nx76AzzjjAyALMmmeeiSAx9vDFnUDz6BSkaIpt8+E24pUHCnnoVUJe iScuAsgijVSzyCGNBLjIf/+9eIgiiirqx5g3vlNMPO5s2iM7xYjDjjzD/AONP19F89VCRh4jDT/+ 0NzD3TzQ8OmnlCB+8gmUovwZCgmGJupHNWFSOl8fhzY6LCPUKHKIomHaiBA8xhQjSzDBrMkOPMmN Iw8848BTSzJIOSbWqtAwNM818+glUDSXhPjJJaGAgh4oIdrbzbyXVAIlJyMcQo0fjeBxyHth+sHI sIr4oQgejQDycJh4KDKHtAfFY8w4sQAjzpmhglvML+i8ws4qySQDWMrIJBOHM9chFUcy0tDzjzRU QHKJKPF2E8qHO58HCieRXMJJvZKQMOnBdNyBRx131PFwwxUf4nQjfcxxyCFz9FEHIsYZE8wXv3Ss yprx0FIMOrL8EswqcJCSjBsq+7KGG8cEBdf+3G649c8YVEQSSSWfVFLJ4KBIwokkkhj+SCSPSBIK Fe7VMcccTdNx+R2az+H05U37UUfTWV8O9o3EwPKFLKyrQnbbHcvySiypwAEY3kG54YYgpLgBRzLI 6N7UP2tEIXglj0vyCCSGQ/LI88pTEXklVIwANeh4dB715ddjzrn3lmN++rSpf/FFLLK4/sr6qqgi SyuqeCHILELhXf8sguiOd1p4l1N8JI2D3vMe57zlKQ96kYjCBeoQvsxpbnuYy14EtdfA8R0EHsSI BStmR4tXsIIVv/ggCD/ohVn84g1uiINchHcM/eVOhXBwQ+AkAbnBRUJ6NHweAAeIvEc4oA7+2aMD 1EbXNCLSIYh18Bodmva9rxmHFvHzghey8AUwSFGKYLAiK1LRgzGEYQpj6IEYCeODMJCBDB05CWF6 0IQnPAEKT2gCCN4YBRDAMQo7eAIVnhCFR7zxARkwQQ00JwQTDEEIHpgDEYQwBw9s4JFDiCQRNjAE IgzBAxgzCDzIQQ5xBIMWa/qF24BRrV+QAx3DyMY/sDMPwCQlGUmRhmcaIxa32PAToODTNsZjCcLZ K1D4AkUlHIClRBxCYgeDD4wgBghk+aEPi3BYfKhRn0wWBB7paIc237EObXrTm+t4x49ewo1ymvOc 6EwnN/SAona6853wFJBxenKRduCEGzj+GQVODFKcG0HEDhixJznzuc+C9HNaEMkAPREiUJfg8yX6 LOhADnpBiDQAKwdpaEse6pKIEoQPAlmGQTBKEIpq0h/2SABJC6JRlnC0JR4dyBwgQgSB0MMc66jH Cypi0mv64xoFWClBWrqSl7IkorpYxz/4MAeB1PQff+jCC8oBAZsSgp/zBKpQB0JUjRh1JRGtw0Iq 6VSB/GEPH6hHBQTSjD/8YxAlHQhKY7KZf8DjpwPYqkC6mpGvaiSidKApEfZADyLYAxt/mIAC7rHW f2CgD/9IQlwFQi7h/cAed9VqPe/5Dzp0VCB0KMQ/NEADG9SBCJhDQwAIoFaBaKAC9SD+gi70IZCD OkZlsJoHPMzBgrxeRKkXgQ1BzqELfD71IvToSR6UcA8N4OEfCAgABYhgyQx0QQAHaO1oCXCPIqRA tP/oKUHgIQMVBPUi76BIDbAhkKYS5Bp/MG4/DJINfuDAFkjgwD/6oBJ+PGAIexjAcxUAgAQwgAge qMACBpCAZTRWAwUoxw0WQAhsDEK8A4GHLziQBDOgwQxMQAMc3vCGoEwhDXBYBRrWgIYWl4EGS+CD EVpQgzgEIQhmMAIciuCGDZwADUyogQnQ4AYzBAINQUBCDc6gAQ6gAQlLOIMZzHABJCDBDhs4hh22 vIclLCEIW0ZkB5ZwBA7UoQtcQAL+FmxQhEXMcxn8KIOcYxDlMZxBZWmowi1OUYY3DAINZ8AFLkjB B2WEgwtvuAYa3iCDOJjBDcyIxBIGUQoslGENZQhEGcxQBsxgIxpGLgUZ0KCMPFxDpNFIBkHq4RWB 1AQbZhiEKlHBC3q4whbzYMQ8NcJXjPg1IzEtKIYFcldecxaiEp3orjPS64v8GiPB3uew7brQf2CD H8wwSLMt8uyLRBsn0y72Uv/hC350gRlDGAgv5rvtinTbIt9+Sbj9gYt1pDsJvoDAHjowEFtApN0U eXdF4u2Sedc03YMtwL4Houp/8JUZNnM3QZMd3gL5A+H/qAEeFM5vyu4VIYS4Brf+J55sg/8j3XPI gMItwPCPH4QQZpE4silucpQ3QOEHaPk/gGsQQkxj5DMv+TyJ4I8MZPzmfciux/+R3oP4AgcESXdB BE4RgrfEGvyoCUxuctc5NPcfRJAAzlWian6UqiBm+AchpC4Qtg+E6gixukgx0hpr5M8NPTgGGcbA 93vclQhfn4PYMZDdzcRhla4wCEAPUQOJnJwn7+bHVQ9C8HooQa8CQUZ4zUK3ODhGGq6CRz02EI0J 2GMDDSAABhAwN2iEYSht+I7h54GENhhhA/SYxx6gsYHvVMgecKAEeLrznWRwRxob8IaRigIeK3iH +MrYCxKSYKRZlWEecADPd+L+YI9wzwIaS3FDPvyhE2R8pSn8qAUZfPe7MTRjFltoxhGAQpQ1VCEO e6+HJcQwhd2JIQxOEQ1iMBTRMAbHYIBpQAZhAAclMAZ7NxR710J5EwdxsAZOsAZn4AYLqAZjkAZ2 dgxlcAjLFhEVsQ5zIhCiIRCtMREzIRDcgCE7MRBL0ho6IRMCMQoTgSH2wA91tXVWkRBeoRj+cA/U MIKbNVBBJ1HzZmxI+Fk0Z4QWAXAIAXeUR3EV508EoXkGoXn+IIUHQYUGYXUssYQ6VxCHNw9eWBD8 wAkkp4RG+BQGsQb/kAxp6BAQwQ+S0IbC9oYi1wz18BhjwA/JwHMEwQwr9R3+DpGHF0FS+uQPMVcQ 9ZCCBIFRFOUN9aAkrVFs0gAkQ7EXTiEUa/ALxzAOqyYQgYBR0HAUijEPimgRDVcQVsCDbrAQ2yGD 89AMsKF1S9eCFPULRzCL6QIP0kA3NyMScfAGMaQGaZEGONALAiFyjXEMaAAYJ7gLW8AG0DAG/yAI rXgZLmMQ/mACTVEZ3qAy99AQcOANyFAZLZMuaRAW9KAUqkJR8WgPf2hXz/AGUzAJvhBDRTEGgpAJ x0AKZDALtBAHmZAGbAAHYwAHgTAGawAHc3EMA6gGZ9CQMpQMmwA8m7AJmeAMk7AJbDCSY/ALpAAX t5AGm2ACKHYMmTBiDBn+FHAwgEIRBzGEDBLJBjAABmIABz7QCLtmCZZQEao2LlJgD84wh/3GD3EQ iUqiEP9wDfcACmngBDAQAyfQBFNACiCglb5gCfPgDWpQD5SgBSHwBFbgD1o4ENGAIa7QlisIGAJB CZMAM83gD0vYCZ1AEf0gA/8wDMDDg1GpbvuQDNUmEKDABTqQC6bQBE4gBb5ABUd5D0P5D/VGCc5A CTxwBUo5iRDhD7lQEMighS6QCs+gbFjID3tpEeJgJC7RCiugD/pgDjLgBFXwD5zgDf+gf+9Fbzqg TzB4EcfQDAKhD71gDqiJUI4XheEQDg4lcgNBCZ5AgvygmwbxCGJoELg6MF8HQYYBpQ/74FAGIVwW gQnZqRHeeYTimYR7SBH+kE3f1A7dFJ/aJA84kQ/qlJ/ppA3x1J/+iQ8BAQA7 ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcents/x2236.gif R0lGODlhAwAJAPcAAAAAAIAAAACAAICAAAAAgIAAgACAgICAgMDAwP8AAAD/AP//AAAA//8A/wD/ /////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAMwAAZgAAmQAAzAAA/wAzAAAzMwAzZgAzmQAzzAAz/wBm AABmMwBmZgBmmQBmzABm/wCZAACZMwCZZgCZmQCZzACZ/wDMAADMMwDMZgDMmQDMzADM/wD/AAD/ MwD/ZgD/mQD/zAD//zMAADMAMzMAZjMAmTMAzDMA/zMzADMzMzMzZjMzmTMzzDMz/zNmADNmMzNm ZjNmmTNmzDNm/zOZADOZMzOZZjOZmTOZzDOZ/zPMADPMMzPMZjPMmTPMzDPM/zP/ADP/MzP/ZjP/ mTP/zDP//2YAAGYAM2YAZmYAmWYAzGYA/2YzAGYzM2YzZmYzmWYzzGYz/2ZmAGZmM2ZmZmZmmWZm zGZm/2aZAGaZM2aZZmaZmWaZzGaZ/2bMAGbMM2bMZmbMmWbMzGbM/2b/AGb/M2b/Zmb/mWb/zGb/ /5kAAJkAM5kAZpkAmZkAzJkA/5kzAJkzM5kzZpkzmZkzzJkz/5lmAJlmM5lmZplmmZlmzJlm/5mZ AJmZM5mZZpmZmZmZzJmZ/5nMAJnMM5nMZpnMmZnMzJnM/5n/AJn/M5n/Zpn/mZn/zJn//8wAAMwA M8wAZswAmcwAzMwA/8wzAMwzM8wzZswzmcwzzMwz/8xmAMxmM8xmZsxmmcxmzMxm/8yZAMyZM8yZ ZsyZmcyZzMyZ/8zMAMzMM8zMZszMmczMzMzM/8z/AMz/M8z/Zsz/mcz/zMz///8AAP8AM/8AZv8A mf8AzP8A//8zAP8zM/8zZv8zmf8zzP8z//9mAP9mM/9mZv9mmf9mzP9m//+ZAP+ZM/+ZZv+Zmf+Z zP+Z///MAP/MM//MZv/Mmf/MzP/M////AP//M///Zv//mf//zP///yH5BAEAABAALAAAAAADAAkA AAgVAKmhEIhi4MB/CBMmFPivIIpUAwMCADs= ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcstatic.css BODY.pmc-body { MARGIN: 1px } BODY.pmc-body-table { MARGIN: auto auto auto 1px } BODY.pmc-body-figure { MARGIN: auto auto auto 1px } .span-content { =09 } .front-matter-section { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .section-content { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .section-title { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .toc-section-title { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .back-matter-section { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .footer-section { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .back-matter-section { FONT-SIZE: 80% } .section-content { MARGIN-TOP: 0px; LINE-HEIGHT: 1.31em } .section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .toc-section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .banner-color1 { BACKGROUND-COLOR: #3c78bc } .banner-color2 { BACKGROUND-COLOR: #a0c0e0 } .banner-text { PADDING-RIGHT: 0.3em; FONT-WEIGHT: bold; FONT-SIZE: 135%; COLOR: = #ffffff; FONT-STYLE: italic; TEXT-ALIGN: right } .banner-text-sans { FONT-WEIGHT: bold; FONT-SIZE: 120%; COLOR: #ffffff; FONT-FAMILY: = sans-serif; TEXT-ALIGN: right } .banner-generic-logo-background { BACKGROUND-IMAGE: url(../pmcgifs/logo-generic.png); WIDTH: 500px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 75px; BACKGROUND-COLOR: silver } .banner-journal-publisher-over-image { MARGIN-LEFT: 84px; MARGIN-RIGHT: 10px } .banner-journal-name { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: white; PADDING-TOP: 3px; = FONT-FAMILY: sans-serif; HEIGHT: 50px; TEXT-ALIGN: left } .banner-logo-with-journal-title-over { HEIGHT: 75px } .banner-logo-with-journal-title-over-placeholder { FONT-SIZE: 20px; Z-INDEX: 1000; LEFT: 105px; WIDTH: 390px; POSITION: = relative; TOP: -75px } .banner-logo-with-journal-title-over-placeholder-content { FONT-WEIGHT: bold; COLOR: white; PADDING-TOP: 3px; FONT-FAMILY: = Calibri, "Trebushet MS", Arial, sans-serif; HEIGHT: 50px; TEXT-ALIGN: = center } .over-logo-journal-title-sageopen { COLOR: #0055a5 } .over-logo-journal-title-sfesd { COLOR: #ffffff } .over-logo-journal-title-acssd { COLOR: #1e73b3 } .over-logo-journal-title-apasd { COLOR: #1e73b3 } .over-logo-journal-title-esesd { LINE-HEIGHT: 47px } .over-logo-journal-title-srfsd { LINE-HEIGHT: 47px } .banner-publisher-name { FONT-WEIGHT: bold; FONT-SIZE: 0.8em; COLOR: #0050a0; TEXT-ALIGN: right } .menu-link { FONT-WEIGHT: bold; FONT-SIZE: 13px; COLOR: #0000c0; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-ALIGN: center; TEXT-DECORATION: none } A.menu-link:visited { FONT-WEIGHT: bold; FONT-SIZE: 13px; COLOR: #0000c0; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-ALIGN: center; TEXT-DECORATION: none } .menu-curr-page { FONT-WEIGHT: bold; FONT-SIZE: 13px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-ALIGN: center } A.menu-link:hover { COLOR: #ffffff; TEXT-DECORATION: none } .header-link { FONT-WEIGHT: bold; FONT-SIZE: 110%; COLOR: #0055aa; FONT-FAMILY: Arial, = sans-serif } .inpage-link { COLOR: #004080 } .sans75 { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .sans80 { FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .sans80b { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .sans90 { FONT-SIZE: 90%; FONT-FAMILY: Arial, sans-serif } .sans90b { FONT-WEIGHT: bold; FONT-SIZE: 90%; FONT-FAMILY: Arial, sans-serif } .sans { FONT-FAMILY: Arial, sans-serif } .sans105b { FONT-WEIGHT: bold; FONT-SIZE: 105%; FONT-FAMILY: Arial, sans-serif } .sans125b { FONT-WEIGHT: bold; FONT-SIZE: 125%; FONT-FAMILY: Arial, sans-serif } .msg-error { FONT-WEIGHT: bold; BACKGROUND: yellow; COLOR: red } .msg-warning { FONT-WEIGHT: bold; BACKGROUND: yellow; COLOR: brown } .eqn-image { MARGIN: 5px } A.navlink { COLOR: #0055aa; TEXT-DECORATION: none } A.navlink:hover { TEXT-DECORATION: underline } .navlink-box { FONT-WEIGHT: bold; FONT-SIZE: 80%; PADDING-BOTTOM: 2px; WIDTH: 683px; = PADDING-TOP: 2px; BORDER-BOTTOM: #cccccc 6px solid; FONT-FAMILY: tahoma, = verdana, Arial, sans-serif } .navlink-box-black { BORDER-BOTTOM: #000000 6px solid } .navlink-box-brtblue { BORDER-BOTTOM: #649afc 6px solid } .navlink-box-dkgreen { BORDER-BOTTOM: #006666 6px solid } .navlink-box-gray { BORDER-BOTTOM: #cccecc 6px solid } .navlink-box-green { BORDER-BOTTOM: #dce6e4 6px solid } .navlink-box-ltblue { BORDER-BOTTOM: #9ccefc 6px solid } .navlink-box-slateblue { BORDER-BOTTOM: #6c9acc 6px solid } .navlink-box-teal { BORDER-BOTTOM: #9ccecc 6px solid } .navlink-box-navy { BORDER-BOTTOM: #003399 6px solid } .navlink-box-bcwm-combo-blue { BORDER-BOTTOM: #639ace 3px solid } .fm-related-articles { BORDER-RIGHT: #ccd8e4 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #ccd8e4 1px solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN-LEFT: = 10px; BORDER-LEFT: #666699 1px solid; LINE-HEIGHT: 140%; MARGIN-RIGHT: = 15px; PADDING-TOP: 5px; BORDER-BOTTOM: #666699 1px solid } .nihms-highlight { FONT-WEIGHT: bold; FONT-SIZE: 0.8em; BACKGROUND: yellow; FLOAT: left; = MARGIN: 0px 0.2em 0px 0px; WIDTH: 4em; COLOR: #990000; TEXT-ALIGN: = center } .retraction-notice { FONT-WEIGHT: bold; FONT-SIZE: 1.2em; COLOR: red } .retraction-notice A { COLOR: red } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TR[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TD[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TABLE.rendered TD { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0.2em; = PADDING-TOP: 0.2em } TABLE.rendered TH { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0.2em; = PADDING-TOP: 0.2em } TABLE.rendered TD { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'top'] { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'middle'] { VERTICAL-ALIGN: middle } TABLE.rendered TD[valign=3D'bottom'] { VERTICAL-ALIGN: bottom } .head1 { FONT-SIZE: 120% } .head2 { FONT-SIZE: 110% } .head3 { FONT-SIZE: 105% } .head4 { FONT-SIZE: 99% } .head5 { FONT-SIZE: 90% } .acknowledgment-journal-title { FONT-STYLE: italic } DIV.exception-box { BORDER-RIGHT: silver 1px dashed; PADDING-RIGHT: 0.3em; BORDER-TOP: = silver 1px dashed; PADDING-LEFT: 0.3em; FONT-SIZE: 0.87em; = MARGIN-BOTTOM: 1.31em; PADDING-BOTTOM: 0.3em; BORDER-LEFT: silver 1px = dashed; PADDING-TOP: 0.3em; BORDER-BOTTOM: silver 1px dashed } DIV.exception-box .front-matter-section { FONT-SIZE: 1.14em } .box { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } DIV.p { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } .box { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-first { MARGIN-TOP: 0px } DIV.sec-first { MARGIN-TOP: 0px } DIV.p-last { MARGIN-BOTTOM: 0px } DIV.sec-last { MARGIN-BOTTOM: 0px } DIV.p-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } DIV.sec-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } SUP { FONT-SIZE: 0.8em; LINE-HEIGHT: 0.8em; WHITE-SPACE: nowrap } SUB { FONT-SIZE: 0.8em; LINE-HEIGHT: 0.8em; WHITE-SPACE: nowrap } .footnote-char { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-ec { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.3em } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcbase1.css BODY { BACKGROUND-COLOR: #f8f8f8 } .small-caps { FONT-SIZE: 80%; FONT-VARIANT: small-caps } .monospace { FONT-FAMILY: monospace } .pmctop-bg { BACKGROUND-COLOR: #fffeee } A.pmctop { FONT-SIZE: 12px; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .pmc-body A:active { TEXT-DECORATION: underline } .pmc-body A:hover { TEXT-DECORATION: underline } .pmc-body-table A:active { TEXT-DECORATION: underline } .pmc-body-table A:hover { TEXT-DECORATION: underline } .pmc-body-figure A:active { TEXT-DECORATION: underline } .pmc-body-figure A:hover { TEXT-DECORATION: underline } .pmc-body A:hover { TEXT-DECORATION: underline } .pmc-body A:hover { =09 } .pmc-body-table A:hover { =09 } .pmc-body-figure A:hover { =09 } HR { COLOR: #0072a8 } .base-highlight1 { BACKGROUND-COLOR: #ebebeb } .base-highlight2 { BACKGROUND-COLOR: #cccccc } .controls { FONT-WEIGHT: bold; FONT-SIZE: 75%; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-DECORATION: none } .formtext { FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .link { COLOR: #0055aa; TEXT-DECORATION: none } .footer-link { FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: center } .side-head { FONT-WEIGHT: bold; FONT-SIZE: 90%; FONT-FAMILY: Arial, sans-serif } .side-subhead { MARGIN-TOP: 10px; FONT-WEIGHT: bold; FONT-SIZE: 75%; FONT-FAMILY: = Arial, sans-serif } .side-item { FONT-SIZE: 75%; PADDING-BOTTOM: 2px; MARGIN: 2px 1px 2px 4px; = BORDER-BOTTOM: #c0c0c0 1px solid; FONT-FAMILY: Arial, sans-serif } .side-curr-item { FONT-SIZE: 75%; PADDING-BOTTOM: 2px; MARGIN: 2px 1px 2px 4px; = BORDER-BOTTOM: #c0c0c0 1px solid; FONT-FAMILY: Arial, sans-serif } .side-item A { COLOR: #0055aa; TEXT-DECORATION: none } .side-curr-item { COLOR: #808080 } .toc-header-vid { MARGIN-TOP: 1.1em; FONT-WEIGHT: bold; FONT-SIZE: 120%; MARGIN-BOTTOM: = 1.1em; LINE-HEIGHT: 1.1em; FONT-FAMILY: Arial, sans-serif } .more-iss-text { MARGIN-TOP: 1.35em; FONT-WEIGHT: bold; MARGIN-BOTTOM: 1.35em; = FONT-FAMILY: Arial, sans-serif } .more-iss-link { COLOR: #0055aa; TEXT-DECORATION: none } .arc-issue { FONT-SIZE: 80%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-ALIGN: center; TEXT-DECORATION: none } .toc-entry { LINE-HEIGHT: 1.12em } .portal-tocentry { LINE-HEIGHT: 1.12em } .toc-comment { FONT-SIZE: 70%; FONT-FAMILY: Arial, sans-serif } .toc-title { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .toc-author { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-cit-ver { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif } .toc-cit-jour { FONT-SIZE: 75%; COLOR: #666666; FONT-STYLE: italic; FONT-FAMILY: Arial, = sans-serif } .toc-cit-vol { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif } .toc-cit-page { FONT-WEIGHT: bold; FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, = sans-serif } .toc-cit-date { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif; = WHITE-SPACE: nowrap } .toc-pmcid { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif; = WHITE-SPACE: nowrap } .toc-link { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-DECORATION: none } A.toc-link { COLOR: #004080 } .toc-divider { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-DECORATION: none } .toc-corrected-citation { MARGIN-LEFT: 1em } .toc-corrected-prefix { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-1st-author-etal { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-citation-title { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-prefix { FONT-WEIGHT: 600 } .toc-corrected-citation-info { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-citation-info .citation-abbreviation { FONT-STYLE: italic } .toc-entry-abstract-toc { PADDING-RIGHT: 2em; PADDING-LEFT: 2em; FONT-SIZE: 75%; PADDING-BOTTOM: = 0px; COLOR: #333; PADDING-TOP: 0px; FONT-FAMILY: Arial, san-serif } .cited-article-fm { BORDER-RIGHT: 1px solid; PADDING-RIGHT: 8px; BORDER-TOP: 1px solid; = PADDING-LEFT: 8px; MARGIN-LEFT: 0px; BORDER-LEFT: 1px solid; = BORDER-BOTTOM: 1px solid; BACKGROUND-COLOR: #ebebeb } .citing-article-fm { PADDING-RIGHT: 8px; PADDING-LEFT: 8px; MARGIN-LEFT: 0px } .sidefm-pmchead { FONT-WEIGHT: bold; FONT-SIZE: 85%; COLOR: #0055aa; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-DECORATION: none } .sidefm-pmhead { FONT-WEIGHT: bold; FONT-SIZE: 85%; COLOR: #0055aa; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-DECORATION: none } .sidefm-pmsubhead { MARGIN-TOP: 10px; FONT-WEIGHT: bold; FONT-SIZE: 75%; COLOR: #000000; = FONT-FAMILY: Arial, sans-serif } .sidefm-pmclink { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .sidefm-pmart { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .side-section { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .side-caption { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .figure-table-caption-in-article { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } SELECT.sidefm-pmart { WIDTH: 145px } .figure-table-caption-in-article { COLOR: #000000; LINE-HEIGHT: 1.5em } .sidefm-pmclink-item { PADDING-LEFT: 10px } .sidefm-pmclink-item A { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmccurrent-item A { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmclink-item A:hover { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmccurrent-item A:hover { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmclink-item A { COLOR: #004080 } .sidefm-pmclink-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A { CURSOR: default; COLOR: #808080 } .sidefm-pmccurrent-item A:hover { CURSOR: default; COLOR: #808080 } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #dcdcdc } .side-section-curr { FONT-SIZE: 75%; COLOR: #808080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .sidebar-cell .sidefm-supplink { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .sidebar-cell .side-supplink { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } A.sidefm-supplink { COLOR: #b55a00; TEXT-DECORATION: none } A.side-supplink { COLOR: #b55a00; TEXT-DECORATION: none } .side-section-group { PADDING-RIGHT: 3px; BORDER-TOP: #0077aa 1px solid; PADDING-LEFT: 3px; = LINE-HEIGHT: 100%; TEXT-DECORATION: none } .head-separate { MARGIN-BOTTOM: 1.2em } .links-box { BORDER-RIGHT: #ccd8e4 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #ccd8e4 1px solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: 1em = 0px; BORDER-LEFT: #666699 1px solid; PADDING-TOP: 5px; BORDER-BOTTOM: = #666699 1px solid } :unknown { BORDER-RIGHT: #336699 1px dotted; BORDER-TOP: #336699 1px dotted; = BORDER-LEFT: #336699 1px dotted; BORDER-BOTTOM: #336699 1px dotted } .main-table-content { MARGIN-LEFT: 9px } .main-figure-content { MARGIN-LEFT: 9px } DIV.fm-author { MARGIN-TOP: 16px! important; MARGIN-BOTTOM: 16px! important } .fm-affl { FONT-WEIGHT: normal; COLOR: #5e5e5e! important } .fm-footnote { FONT-WEIGHT: normal; COLOR: #5e5e5e! important } .fm-editor { FONT-WEIGHT: normal; COLOR: #5e5e5e! important } DIV.fm-affl { MARGIN: 0px } DIV.fm-footnote { MARGIN: 0px } DIV.fm-copyright { MARGIN-TOP: 12px! important; MARGIN-BOTTOM: 12px! important } DIV.fm-pubdate { MARGIN-TOP: 12px! important; MARGIN-BOTTOM: 12px! important } DIV.fm-citation { MARGIN-TOP: 0px! important } .fm-citation-ids { PADDING-LEFT: 1em; FONT-SIZE: 85%; FONT-FAMILY: Arial,sans-serif; = WHITE-SPACE: nowrap; TEXT-ALIGN: right } .fm-citation-ids-label { COLOR: #666 } .fm-citation-pmcid { =09 } .fm-citation-manuscriptid { =09 } .fm-citation-other-versions-label { CURSOR: hand; COLOR: #0050a0 } .fm-citation-this-version-label { COLOR: #666666 } .fm-citation-versions { POSITION: relative } .fm-citation-versions .fm-citation-verions-list-canvas { BORDER-RIGHT: #444 1em solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #444 = 1em solid; DISPLAY: none; PADDING-LEFT: 0.5em; RIGHT: 0px; = PADDING-BOTTOM: 0.5em; BORDER-LEFT: #444 1em solid; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #444 1em solid; POSITION: absolute; TOP: 1.1em; = BACKGROUND-COLOR: #444 } .fm-citation-versions:hover .fm-citation-verions-list-canvas { DISPLAY: block } .show-hover .fm-citation-verions-list-canvas { DISPLAY: block } .fm-citation-versions .fm-citation-verions-list { BORDER-RIGHT: #639ace 3px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: = #639ace 3px solid; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = BORDER-LEFT: #639ace 3px solid; PADDING-TOP: 0.5em; BORDER-BOTTOM: = #639ace 3px solid; BACKGROUND-COLOR: #f8f8f8; TEXT-ALIGN: left } .fm-citation-verions-list .version { MARGIN-LEFT: 15px } .fm-copyright { MARGIN-TOP: 6px } .links-box .fm-footnote { MARGIN: 0px } .tocentry { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-LEFT: 2.5em } .toc-entry-alt-lang-msg { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .portal-tocentry { MARGIN-TOP: 1.6ex; MARGIN-BOTTOM: 2ex; MARGIN-RIGHT: 1em } .button-elsevierwt { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .elsevierwt-sponsored-label { FONT-WEIGHT: 600; COLOR: #f8f8f8 } .banner-journal-publisher-over-image-elsevierwt { MARGIN-LEFT: 20px; OVERFLOW: hidden; COLOR: #9a7947; LINE-HEIGHT: = 1.5em; MARGIN-RIGHT: 145px; FONT-FAMILY: Georgia, "Times New Roman", = Times, serif; POSITION: relative; TOP: -30px; HEIGHT: 75px } .banner-journal-name-elsevierwt { FONT-WEIGHT: 600; FONT-SIZE: 1.2em; MARGIN-LEFT: 1em; COLOR: #954a4a } A.elsevierwt-button-link { LEFT: 360px; POSITION: relative; TOP: 40px } A.elsevierwt-button-link:hover { BACKGROUND-COLOR: #f1e8ce } .fm-elsevierwt-disclaimer { MARGIN-TOP: 12px; FONT-SIZE: 0.68em; MARGIN-BOTTOM: 12px; FONT-FAMILY: = Arial, sans-serif } .ref-cit-blk { MARGIN-TOP: 1.4em; LINE-HEIGHT: 1.4em } .back-ref-list-1st-line-shifted LI { MARGIN-TOP: 1.4em; LINE-HEIGHT: 1.4em } .back-ref-list LI { MARGIN-TOP: 1.4em; LINE-HEIGHT: 1.4em } DIV.ref-label { BORDER-RIGHT: #f8f8f8 1px solid; BORDER-TOP: #f8f8f8 1px solid; FLOAT: = left; BORDER-LEFT: #f8f8f8 1px solid; WIDTH: 45px; BORDER-BOTTOM: = #f8f8f8 1px solid; TEXT-ALIGN: right } DIV.ref-cit { MARGIN-LEFT: 55px } SPAN.ref-label { FONT-STYLE: italic } SPAN.ref-cit { =09 } .back-ref-list-1st-line-shifted LI { PADDING-LEFT: 1.5em; MARGIN-LEFT: 2em; TEXT-INDENT: -1.5em; = LIST-STYLE-TYPE: none } .array-table { MARGIN-TOP: 1em; MARGIN-BOTTOM: 1em; WIDTH: 100%; LINE-HEIGHT: 1.31em; = BACKGROUND-COLOR: #f4f4f4 } .array-table-inline { MARGIN-TOP: 1em; MARGIN-BOTTOM: 1em; WIDTH: 100%; LINE-HEIGHT: 1.31em; = BACKGROUND-COLOR: #f4f4f4 } .array-table TD { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0em; = PADDING-TOP: 0em } .array-table-inline { DISPLAY: inline } .list-item-w-pw { BORDER-RIGHT: #f8f8f8 1px solid; BORDER-TOP: #f8f8f8 1px solid; = BORDER-LEFT: #f8f8f8 1px solid; BORDER-BOTTOM: #f8f8f8 1px solid } .list-item-w-pw-prefix-word { DISPLAY: inline-block; POSITION: relative; TEXT-ALIGN: right } .list-item-w-pw-content { POSITION: relative; TOP: -1.35em } .list-item-p-question { FONT-WEIGHT: bold } SPAN.underline { BORDER-BOTTOM: black 1px solid } SPAN.double-underline { BORDER-BOTTOM: black 3px double } SPAN.bold-double-underline { BORDER-BOTTOM: black 3px double } .verse-group { FONT-SIZE: 1.12em; MARGIN: 1.31em 2em; LINE-HEIGHT: 1.16em; = FONT-FAMILY: "Monotype Corsiva", "Apple Chancery", "URW Chancery L", = cursive } .internal-control { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.5em; MARGIN: 1.5em auto; WIDTH: 95%; PADDING-TOP: = 0.5em; BACKGROUND-COLOR: #f0f0f0 } .sidebar-menu-square-image-holder { PADDING-RIGHT: 0.35em; VERTICAL-ALIGN: middle; _padding-top: 0.35em } .figure-role { DISPLAY: block; MARGIN: 1em 0px } DIV.signature { MARGIN: 1.8em 0px; FONT-FAMILY: "Monotype Corsiva", "Apple Chancery", = "URW Chancery L", cursive } DIV.simple-list-item-w-label { FLOAT: left; TEXT-INDENT: -2em } .selective-deposit-msg { BORDER-RIGHT: #f4f4f4 0.5em solid; BORDER-TOP: #f4f4f4 0.5em solid; = FONT-SIZE: 80%; BORDER-LEFT: #f4f4f4 0.5em solid; BORDER-BOTTOM: #f4f4f4 = 0.5em solid; FONT-FAMILY: Arial,sans-serif; BACKGROUND-COLOR: #f4f4f4 } .fm-title { MARGIN-TOP: 16px } .fm-trans-title { MARGIN-TOP: 16px } .ukpmc-tocentry-icon { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: text-bottom; MARGIN-RIGHT: 0.25em; = BORDER-RIGHT-WIDTH: 0px } .holding-tocentry-icon { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: text-bottom; MARGIN-RIGHT: 0.25em; = BORDER-RIGHT-WIDTH: 0px } .i18n-debug { BACKGROUND-COLOR: #fff0df } .i18n-debug * { BACKGROUND-COLOR: #fff0df } .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffe2bf } .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffe2bf } .i18n-debug .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffd39f } .i18n-debug .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffd39f } .i18n-debug .i18n-debug .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffc47f } .i18n-debug .i18n-debug .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffc47f } A.i18n-switcher { FONT-WEIGHT: normal; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } A.i18n-switcher:hover { FONT-WEIGHT: normal; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } A.i18n-switcher-current { FONT-WEIGHT: bold; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } A.i18n-switcher-current:hover { FONT-WEIGHT: bold; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } IMG.i18n-switcher { VERTICAL-ALIGN: super; WIDTH: 11px; BORDER-TOP-STYLE: none; = MARGIN-RIGHT: 2px; BORDER-RIGHT-STYLE: none; BORDER-LEFT-STYLE: none; = HEIGHT: 8px; BORDER-BOTTOM-STYLE: none } TD.content-cell { PADDING-LEFT: 0.5em } TD.thumb-cell { WIDTH: 110px } TD.caption-cell { TEXT-ALIGN: left } A.icon-reflink { DISPLAY: block } DIV.thumb-ph { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = PADDING-TOP: 0.5em } DIV.caption-ph { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = PADDING-TOP: 0.5em } DIV.thumb-ph { PADDING-RIGHT: 0px } .figpopup { CURSOR: hand; WHITE-SPACE: nowrap; POSITION: relative } .figpopup > DIV { CURSOR: hand; WHITE-SPACE: nowrap; POSITION: relative } A.fig-table-link:hover { Z-INDEX: 10; COLOR: #444 } .figpopup:hover { Z-INDEX: 10; COLOR: #444 } .figpopup:hover .large-thumb-canvas { Z-INDEX: 10; COLOR: #444 } .large-thumb-canvas { BORDER-RIGHT: #444 1em solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #444 = 1em solid; DISPLAY: none; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = MARGIN: 0.5em; BORDER-LEFT: #444 1em solid; COLOR: #444; PADDING-TOP: = 0.5em; BORDER-BOTTOM: #444 1em solid; POSITION: absolute; = BACKGROUND-COLOR: #444 } .large-thumb-canvas-1 { BORDER-RIGHT: #eee 0.25em solid; BORDER-TOP: #eee 0.25em solid; = DISPLAY: block; BORDER-LEFT: #eee 0.25em solid; BORDER-BOTTOM: #eee = 0.25em solid } IMG.large-thumb { WIDTH: 450px } DIV.small-thumb-canvas { BORDER-RIGHT: #444 1px solid; BORDER-TOP: #444 1px solid; BORDER-LEFT: = #444 1px solid; BORDER-BOTTOM: #444 1px solid } DIV.small-thumb-canvas-1 { BORDER-RIGHT: white 1px solid; BORDER-TOP: white 1px solid; = BORDER-LEFT: white 1px solid; BORDER-BOTTOM: white 1px solid } IMG.small-thumb { BORDER-RIGHT: #444 1px solid; BORDER-TOP: #444 1px solid; BORDER-LEFT: = #444 1px solid; WIDTH: 100px; BORDER-BOTTOM: #444 1px solid } .canvas-figure-ref-outer { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; MARGIN: = 0.5em; BORDER-LEFT: #aaaaaa 1px solid; BORDER-BOTTOM: #aaaaaa 1px solid } .canvas-table-ref-outer { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; MARGIN: = 0.5em; BORDER-LEFT: #aaaaaa 1px solid; BORDER-BOTTOM: #aaaaaa 1px solid } .canvas-media-ref-outer { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; MARGIN: = 0.5em; BORDER-LEFT: #aaaaaa 1px solid; BORDER-BOTTOM: #aaaaaa 1px solid } .canvas-figure-ref-inner { BORDER-RIGHT: #f0f0f0 3px solid; BORDER-TOP: #f0f0f0 3px solid; = BORDER-LEFT: #f0f0f0 3px solid; BORDER-BOTTOM: #f0f0f0 3px solid } .canvas-table-ref-inner { BORDER-RIGHT: #f0f0f0 3px solid; BORDER-TOP: #f0f0f0 3px solid; = BORDER-LEFT: #f0f0f0 3px solid; BORDER-BOTTOM: #f0f0f0 3px solid } .canvas-media-ref-inner { BORDER-RIGHT: #f0f0f0 3px solid; BORDER-TOP: #f0f0f0 3px solid; = BORDER-LEFT: #f0f0f0 3px solid; BORDER-BOTTOM: #f0f0f0 3px solid } .figpopup-sensitive-area { FILTER: alpha(opacity=3D0); CURSOR: hand; COLOR: transparent; POSITION: = absolute; TOP: 0px; BACKGROUND-COLOR: transparent; TEXT-DECORATION: = none; opacity: 0 } .canvas-media-player-outer { BORDER-RIGHT: #4a4a4a 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #4a4a4a 2px solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; MARGIN: auto; = BORDER-LEFT: #4a4a4a 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #4a4a4a = 2px solid } .canvas-media-player-inner { BORDER-RIGHT: #4a4a4a 2px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #4a4a4a 2px solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; BORDER-LEFT: = #4a4a4a 2px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #4a4a4a 2px solid; = BACKGROUND-COLOR: #4a4a4a; TEXT-ALIGN: center } .canvas-player-screen { DISPLAY: block; MARGIN: auto; CURSOR: hand; POSITION: relative; = BACKGROUND-COLOR: #4a4a4a; TEXT-ALIGN: center; TEXT-DECORATION: none } .splash-ph { MAX-WIDTH: 100%; MARGIN: auto; HEIGHT: 100% } .player-play-btn { VERTICAL-ALIGN: middle; POSITION: relative } IMG.player-splash { LEFT: 0px; WIDTH: 100%; POSITION: absolute; TOP: 0px; HEIGHT: 100% } .supplementary-material-media-label-caption { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = PADDING-TOP: 0.5em; BACKGROUND-COLOR: #f4f4f4 } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcbars-navy.css .doc-group1 { FONT-WEIGHT: bold; FONT-SIZE: 110%; COLOR: white; FONT-FAMILY: Verdana, = sans-serif; BACKGROUND-COLOR: #003399 } .doc-group2 { FONT-WEIGHT: bold; COLOR: #ffffff; FONT-FAMILY: Arial, sans-serif; = BACKGROUND-COLOR: #3366cc; TEXT-ALIGN: center } .doc-group3 { FONT-WEIGHT: bold; COLOR: #003399; FONT-FAMILY: Arial, sans-serif; = BACKGROUND-COLOR: #cccccc; TEXT-ALIGN: center } .doc-group4 { =09 } .toc-supp-link { FONT-SIZE: 75%; COLOR: #e64a00; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .toc-highlight1 { BACKGROUND-COLOR: #ffffd0 } .toc-highlight2 { BACKGROUND-COLOR: #ace4ff } .head1 { BORDER-RIGHT: #003399 1pt solid; BORDER-TOP: #003399 1pt solid; = FONT-WEIGHT: bold; FONT-SIZE: 110%; BORDER-LEFT: #003399 1pt solid; = COLOR: white; BORDER-BOTTOM: #003399 1pt solid; FONT-FAMILY: Verdana, = sans-serif; BACKGROUND-COLOR: #003399; TEXT-ALIGN: center } .head1A { FONT-WEIGHT: bold; COLOR: #ffffff; FONT-FAMILY: Arial, sans-serif; = BACKGROUND-COLOR: #3366cc } .append-head1 { FONT-WEIGHT: bold; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: center } .colorbar-link { COLOR: #ffffff } .head1 A:link { COLOR: white } .head1 A:visited { COLOR: white } .head1A A:link { COLOR: white } .head1A A:visited { COLOR: white } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcbody8.css .fm-vol-iss-date { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: left } .fm-citation { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: left } .fm-citation-ids { FONT-SIZE: 75% } .fm-citation .fm-vol-iss-date { FONT-SIZE: 100% } .pubnote { FONT-WEIGHT: bold; FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .pubnote-hilite { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; BACKGROUND-COLOR: = #ebebeb } .fm-dochead { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .fm-doctopic { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-docsubject { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-ser-title { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .fm-supp-title { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .fm-title { FONT-WEIGHT: bold; FONT-SIZE: 125%; FONT-FAMILY: Arial, sans-serif } .fm-subtitle { FONT-WEIGHT: bold; FONT-FAMILY: Arial, sans-serif } .fm-trans-title { FONT-SIZE: 120%; FONT-FAMILY: Arial, sans-serif } .fm-trans-subtitle { FONT-SIZE: 105%; FONT-FAMILY: Arial, sans-serif } .fm-author { FONT-SIZE: 110%; FONT-FAMILY: Arial, sans-serif } .fm-affl { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-pubdate { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-footnote { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-editor { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-author .fm-footnote { FONT-SIZE: 68.5% } .fm-author .fm-affl { FONT-SIZE: 68.5% } .fm-author .fm-footnote .fm-affl { FONT-SIZE: 100%; FONT-FAMILY: Arial, sans-serif } .fm-editor .fm-footnote .fm-affl { FONT-SIZE: 100%; FONT-FAMILY: Arial, sans-serif } .fm-editor .fm-footnote { FONT-SIZE: 100%; FONT-FAMILY: Arial, sans-serif } .fm-role { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif } .fm-copyright { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .pmcnote { FONT-SIZE: 85%; FONT-FAMILY: Arial, sans-serif } .abs-head2 { FONT-FAMILY: Arial, sans-serif } .abs-head2 { FONT-WEIGHT: bold } .kwd-label { FONT-WEIGHT: bold } .head2 { FONT-WEIGHT: bold; FONT-FAMILY: Arial, sans-serif } .head3 { FONT-WEIGHT: bold } .head4 { FONT-WEIGHT: bold } .head5 { =09 } .kwd-text { =09 } .eqn-image { TEXT-ALIGN: center } .eqn-id { FONT-WEIGHT: bold; TEXT-ALIGN: right } .box { BORDER-RIGHT: #60cfff 1px solid; BORDER-TOP: #60cfff 1px solid; = OVERFLOW: auto; BORDER-LEFT: #60cfff 1px solid; BORDER-BOTTOM: #60cfff = 1px solid; BACKGROUND-COLOR: #e1e1e1 } .boxhead1 { FONT-WEIGHT: bold; FONT-SIZE: 105%; FONT-FAMILY: Arial, sans-serif } .boxhead2 { FONT-WEIGHT: bold } .fig-table-link { COLOR: #0050a0 } A.cite-reflink { COLOR: #0050a0 } A.int-reflink { COLOR: #0050a0 } A.ext-reflink { COLOR: #0050a0 } .figwind-cite { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .figwind-copyrt { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .product-source { FONT-STYLE: italic } .signature-group { FONT-WEIGHT: bold; MARGIN-LEFT: 2em; FONT-STYLE: italic } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcrefs1.css .ref-id { } .ref-title { } .ref-author { } .ref-journal { FONT-STYLE: italic } .ref-pubdate { } .ref-vol { } .ref-iss { } .ref-page { } .ref-edition { } .ref-editor { } .ref-pubname { } .ref-publoc { } .ref-extlink { COLOR: #0050a0 } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/jsutils/css/tileshop_pmc.1/tileshop_pmc.1.css .viewport { -moz-user-select: none; -khtml-user-select: none; user-select: none } .viewport-static-image { -moz-user-select: none; -khtml-user-select: none; user-select: none } .panorama { -moz-user-select: none; -khtml-user-select: none; user-select: none } .scale-pmc { -moz-user-select: none; -khtml-user-select: none; user-select: none } .viewport { FLOAT: left } .viewport-static-image { FLOAT: left } .viewport { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif); = OVERFLOW: hidden } .viewport .dnd { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif) } .dnd { MARGIN-LEFT: auto; CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/grab.cur), move; = MARGIN-RIGHT: auto } .moving { CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/grabbing.cur), move } .viewport-static-image { BACKGROUND-IMAGE: none; OVERFLOW: hidden; BACKGROUND-COLOR: #ccc } .viewport-static-image IMG { CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/zoomin.cur), auto } .tileshop { FLOAT: left; CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/zoomin.cur), auto; = BACKGROUND-COLOR: #fff } .nodrag { CURSOR: default } .static { BACKGROUND-IMAGE: none; CURSOR: default; BACKGROUND-COLOR: #ccc } .static IMG { BACKGROUND-IMAGE: none; CURSOR: default; BACKGROUND-COLOR: #ccc } .half-static { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc } .half-static IMG { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc } .tile-fill { BACKGROUND-COLOR: #f0f } .panorama { BORDER-RIGHT: #f0ffff 3px solid; BORDER-TOP: black 1px solid; = BORDER-LEFT: black 1px solid; BACKGROUND-COLOR: #ecf0f4; = BORDER-BOTTOM-STYLE: none } .panorama DIV { OVERFLOW: hidden } .panorama IMG { CURSOR: pointer } .pan-switcher { BORDER-RIGHT: #000 1px solid; BORDER-TOP: #000 1px solid; = BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/pan_close.gif); = BORDER-LEFT: #000 1px solid; WIDTH: 10px; CURSOR: pointer; = BORDER-BOTTOM: #000 1px solid; BACKGROUND-REPEAT: no-repeat; HEIGHT: = 10px; BACKGROUND-COLOR: #fff; _background-color: transparent; _border: = none } .pan-switcher-close { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/pan_open.gif) } .pan { BORDER-RIGHT: #000 2px dotted; BORDER-TOP: #000 2px dotted; FONT-SIZE: = 1px; FILTER: alpha(opacity=3D70); BORDER-LEFT: #000 2px dotted; CURSOR: = move; BORDER-BOTTOM: #000 2px dotted; BACKGROUND-COLOR: #dce0e4; = opacity: 0.7 } DIV.panel { BORDER-RIGHT: gray 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: gray 1px = solid; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px; = BORDER-LEFT: gray 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: gray 1px = solid; BACKGROUND-COLOR: #ecf0f4 } DIV.panel P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MIN-HEIGHT: 21px; FLOAT: left; = PADDING-BOTTOM: 0.2em; MARGIN: 0px; WIDTH: 100%; PADDING-TOP: 0.1em; = BACKGROUND-COLOR: #ecf0f4; TEXT-ALIGN: center } DIV.panel P SPAN { PADDING-LEFT: 25px; FLOAT: left; MARGIN: 0px; WIDTH: 85% } DIV.panel P A { DISPLAY: none; MIN-HEIGHT: 21px; TEXT-DECORATION: none } DIV.panel P A.active { BACKGROUND-POSITION: 13px 0px; DISPLAY: block; FLOAT: right; = BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/toolbar.png); MARGIN: 0px = 9px 0px 0px; WIDTH: 36px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 21px; = _background-image: url(../../img/tileshop_pmc.1/toolbar.gif); = _margin-right: 5px } DIV.panel P A.active:hover { BACKGROUND-POSITION: -67px 0px; BACKGROUND-REPEAT: no-repeat; = BACKGROUND-COLOR: #ecf0f4; TEXT-DECORATION: none } DIV.panel DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.panel DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.panel DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.panel DT IMG { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV.panel DL { FLOAT: left; WIDTH: 100% } DIV.panel DL DD { FLOAT: right } DIV.panel DL DT { FLOAT: left; BACKGROUND-IMAGE: = url(../../img/tileshop_pmc.1/loading_bg.gif) } .scale-pmc { MARGIN: auto; WIDTH: 32px; PADDING-TOP: 0em } .scale-pmc A { PADDING-RIGHT: 1px; DISPLAY: block; PADDING-LEFT: 1px; FONT-SIZE: 3px; = BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/toolbar.png); = PADDING-BOTTOM: 1px; MARGIN: 0px; PADDING-TOP: 1px; BACKGROUND-REPEAT: = no-repeat; HEIGHT: 16px; TEXT-DECORATION: none; _background-image: = url(../../img/tileshop_pmc.1/toolbar.gif) } .scale-pmc A:hover { BACKGROUND-REPEAT: no-repeat; BACKGROUND-COLOR: transparent; = TEXT-DECORATION: none } .scale-pmc A.scale-up { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-up-disabled { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-down-disabled { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-down { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-up { BACKGROUND-POSITION: 4px -26px } .scale-pmc A.scale-up:hover { BACKGROUND-POSITION: -76px -26px } .scale-pmc A.scale-up-disabled { BACKGROUND-POSITION: -36px -26px; CURSOR: default } .scale-pmc A.scale-down { BACKGROUND-POSITION: 4px -226px } .scale-pmc A.scale-down:hover { BACKGROUND-POSITION: -76px -226px } .scale-pmc A.scale-down-disabled { BACKGROUND-POSITION: -36px -226px; CURSOR: default } .scale-pmc A.scale-1 { BACKGROUND-POSITION: 3px -57px } .scale-pmc A.scale-1:hover { BACKGROUND-POSITION: -77px -57px } .scale-pmc A.selected-1 { BACKGROUND-POSITION: -37px -57px; CURSOR: default } .scale-pmc A.selected-1:hover { BACKGROUND-POSITION: -37px -57px; CURSOR: default } .scale-pmc A.scale-2 { BACKGROUND-POSITION: 3px -77px } .scale-pmc A.scale-2:hover { BACKGROUND-POSITION: -77px -77px } .scale-pmc A.selected-2 { BACKGROUND-POSITION: -37px -77px; CURSOR: default } .scale-pmc A.selected-2:hover { BACKGROUND-POSITION: -37px -77px; CURSOR: default } .scale-pmc A.scale-3 { BACKGROUND-POSITION: 3px -97px } .scale-pmc A.scale-3:hover { BACKGROUND-POSITION: -77px -97px } .scale-pmc A.selected-3 { BACKGROUND-POSITION: -37px -97px; CURSOR: default } .scale-pmc A.selected-3:hover { BACKGROUND-POSITION: -37px -97px; CURSOR: default } .scale-pmc A.scale-4 { BACKGROUND-POSITION: 3px -117px } .scale-pmc A.scale-4:hover { BACKGROUND-POSITION: -77px -117px } .scale-pmc A.selected-4 { BACKGROUND-POSITION: -37px -117px; CURSOR: default } .scale-pmc A.selected-4:hover { BACKGROUND-POSITION: -37px -117px; CURSOR: default } .scale-pmc A.scale-5 { BACKGROUND-POSITION: 3px -137px } .scale-pmc A.scale-5:hover { BACKGROUND-POSITION: -77px -137px } .scale-pmc A.selected-5 { BACKGROUND-POSITION: -37px -137px; CURSOR: default } .scale-pmc A.selected-5:hover { BACKGROUND-POSITION: -37px -137px; CURSOR: default } .scale-pmc A.scale-6 { BACKGROUND-POSITION: 3px -157px } .scale-pmc A.scale-6:hover { BACKGROUND-POSITION: -77px -157px } .scale-pmc A.selected-6 { BACKGROUND-POSITION: -37px -157px; CURSOR: default } .scale-pmc A.selected-6:hover { BACKGROUND-POSITION: -37px -157px; CURSOR: default } .scale-pmc A.scale-7 { BACKGROUND-POSITION: 3px -177px } .scale-pmc A.scale-7:hover { BACKGROUND-POSITION: -77px -177px } .scale-pmc A.selected-7 { BACKGROUND-POSITION: -37px -177px; CURSOR: default } .scale-pmc A.selected-7:hover { BACKGROUND-POSITION: -37px -177px; CURSOR: default } .scale-pmc A.scale-8 { BACKGROUND-POSITION: 3px -207px } .scale-pmc A.scale-8:hover { BACKGROUND-POSITION: -77px -207px } .scale-pmc A.selected-8 { BACKGROUND-POSITION: -37px -207px; CURSOR: default } .scale-pmc A.selected-8:hover { BACKGROUND-POSITION: -37px -207px; CURSOR: default } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/noext-menu.css DIV.sec DIV.other-sections { PADDING-RIGHT: 0.25em; PADDING-LEFT: 0.25em; FLOAT: right; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; POSITION: relative } DIV.other-sections UL { LINE-HEIGHT: 1.2em } .noext-menu UL { DISPLAY: none } .noext-menu { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } .noext-menu UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } .noext-menu A { DISPLAY: block; CURSOR: pointer; TEXT-DECORATION: underline; _display: = inline; outline: none } .noext-menu LI { =09 } .noext-menu A.first-link { FONT-SIZE: 0.65em; TEXT-TRANSFORM: none; WHITE-SPACE: nowrap; = TEXT-DECORATION: none } .noext-menu A.first-link:hover { TEXT-DECORATION: none! important } UL.noext-menu LI SPAN.delta { =09 } .noext-menu LI UL.submenu { DISPLAY: none; FONT-SIZE: 0.75em; POSITION: absolute } .noext-menu LI UL UL { MARGIN: -1em 0px 0px 10em } UL.noext-menu LI.submenu-item UL { DISPLAY: none; POSITION: absolute } UL.noext-menu LI.active-item UL { LEFT: 3px } UL.noext-menu LI UL.opened { BORDER-RIGHT: transparent 1px solid; PADDING-RIGHT: 0.25em; BORDER-TOP: = transparent 1px solid; MARGIN-TOP: 0.25em; MIN-WIDTH: 200px; DISPLAY: = block; PADDING-LEFT: 0.25em; RIGHT: -0.1em; MAX-WIDTH: 300px; = PADDING-BOTTOM: 0.25em; BORDER-LEFT: transparent 1px solid; ; WIDTH: = expression(this.clientWidth > 300 ? "300px" : "200px"); PADDING-TOP: = 0.25em; BORDER-BOTTOM: transparent 1px solid; TOP: 1.4em; _top: 1.6em } UL.noext-menu LI UL.opened LI { MARGIN-BOTTOM: 3px } UL.noext-menu LI UL.opened LI.active-item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BACKGROUND-COLOR: #aaaaaa } UL.opened LI.active-item A { COLOR: #ffffff } UL.noext-menu LI UL A { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: 0px = 3px; COLOR: #222222; PADDING-TOP: 2px; TEXT-DECORATION: none } .noext-menu-hidden { COLOR: transparent! important; BACKGROUND-COLOR: transparent! important } .noext-menu-hidden A.first-link { COLOR: transparent! important; BACKGROUND-COLOR: transparent! important } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/core/extjs/ext-2.2/resources/css/panel.css .x-panel { BORDER-RIGHT: #99bbe8 0px solid; BORDER-TOP: #99bbe8 0px solid; = BORDER-LEFT: #99bbe8 0px solid; BORDER-BOTTOM: #99bbe8 0px solid } .x-panel-header { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #99bbe8 1px solid; PADDING-LEFT: 5px; BACKGROUND: = url(../images/default/panel/white-top-bottom.gif) repeat-x 0px -1px; = PADDING-BOTTOM: 4px; FONT: bold 11px/15px = tahoma,arial,verdana,sans-serif; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: #99bbe8 1px = solid; ZOOM: 1 } .x-panel-body { BORDER-RIGHT: #99bbe8 1px solid; BORDER-TOP: #99bbe8 0px; BACKGROUND: = white; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 1px solid; BORDER-BOTTOM: = #99bbe8 1px solid; POSITION: relative } .x-panel-bbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar-noheader .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-body-noheader { BORDER-TOP: #99bbe8 1px solid } .x-panel-mc .x-panel-body { BORDER-TOP: #99bbe8 1px solid } .x-panel-header { OVERFLOW: hidden; ZOOM: 1 } .x-panel-tl .x-panel-header { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: none transparent scroll repeat 0% 0%; PADDING-BOTTOM: = 4px; FONT: bold 11px tahoma,arial,verdana,sans-serif; BORDER-LEFT: 0px; = COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: 0px } .x-panel-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-window-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-panel-inline-icon { BACKGROUND-POSITION: 0px 0px; MARGIN-TOP: -1px; MARGIN-BOTTOM: -1px; = VERTICAL-ALIGN: middle; WIDTH: 16px; MARGIN-RIGHT: 4px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px } .x-panel-tc { BACKGROUND: url(../images/default/panel/top-bottom.gif) repeat-x 0px = 0px; OVERFLOW: hidden } .ext-strict .ext-ie7 .x-panel-tc { OVERFLOW: visible } .x-panel-tl { PADDING-LEFT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat 0px 0px; = BORDER-BOTTOM: #99bbe8 1px solid; ZOOM: 1 } .x-panel-tr { PADDING-RIGHT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat right 0px; = ZOOM: 1 } .x-panel-bc { BACKGROUND: url(../images/default/panel/top-bottom.gif) repeat-x 0px = bottom; ZOOM: 1 } .x-panel-bc .x-panel-footer { ZOOM: 1 } .x-panel-bl { PADDING-LEFT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat 0px bottom; = ZOOM: 1 } .x-panel-br { PADDING-RIGHT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat right bottom; = ZOOM: 1 } .x-panel-mc { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: #dfe8f6; PADDING-BOTTOM: 0px; MARGIN: 0px; FONT: 11px = tahoma,arial,helvetica,sans-serif; BORDER-LEFT: 0px; PADDING-TOP: 6px; = BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { PADDING-LEFT: 6px; BACKGROUND: = url(../images/default/panel/left-right.gif) #fff repeat-y 0px 0px; ZOOM: = 1 } .x-panel-mr { PADDING-RIGHT: 6px; BACKGROUND: = url(../images/default/panel/left-right.gif) repeat-y right 0px; ZOOM: 1 } .x-panel-bc .x-panel-footer { PADDING-BOTTOM: 6px } .x-panel-nofooter .x-panel-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-nofooter .x-window-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-bwrap { LEFT: 0px; OVERFLOW: hidden; ZOOM: 1; TOP: 0px } .x-panel-body { OVERFLOW: hidden; ZOOM: 1 } .x-panel-collapsed .x-resizable-handle { DISPLAY: none } .ext-gecko .x-panel-animated DIV { OVERFLOW: hidden! important } .x-plain-body { OVERFLOW: hidden } .x-plain-bbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-tbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-bwrap { OVERFLOW: hidden; ZOOM: 1 } .x-plain { OVERFLOW: hidden } .x-tool { BACKGROUND: url(../images/default/panel/tool-sprites.gif) no-repeat; = FLOAT: right; MARGIN-LEFT: 2px; OVERFLOW: hidden; WIDTH: 15px; CURSOR: = pointer; HEIGHT: 15px } .x-tool-toggle { BACKGROUND-POSITION: 0px -60px } .x-tool-toggle-over { BACKGROUND-POSITION: -15px -60px } .x-panel-collapsed .x-tool-toggle { BACKGROUND-POSITION: 0px -75px } .x-panel-collapsed .x-tool-toggle-over { BACKGROUND-POSITION: -15px -75px } .x-tool-close { BACKGROUND-POSITION: 0px 0px } .x-tool-close-over { BACKGROUND-POSITION: -15px 0px } .x-tool-minimize { BACKGROUND-POSITION: 0px -15px } .x-tool-minimize-over { BACKGROUND-POSITION: -15px -15px } .x-tool-maximize { BACKGROUND-POSITION: 0px -30px } .x-tool-maximize-over { BACKGROUND-POSITION: -15px -30px } .x-tool-restore { BACKGROUND-POSITION: 0px -45px } .x-tool-restore-over { BACKGROUND-POSITION: -15px -45px } .x-tool-gear { BACKGROUND-POSITION: 0px -90px } .x-tool-gear-over { BACKGROUND-POSITION: -15px -90px } .x-tool-pin { BACKGROUND-POSITION: 0px -135px } .x-tool-pin-over { BACKGROUND-POSITION: -15px -135px } .x-tool-unpin { BACKGROUND-POSITION: 0px -150px } .x-tool-unpin-over { BACKGROUND-POSITION: -15px -150px } .x-tool-right { BACKGROUND-POSITION: 0px -165px } .x-tool-right-over { BACKGROUND-POSITION: -15px -165px } .x-tool-left { BACKGROUND-POSITION: 0px -180px } .x-tool-left-over { BACKGROUND-POSITION: -15px -180px } .x-tool-up { BACKGROUND-POSITION: 0px -210px } .x-tool-up-over { BACKGROUND-POSITION: -15px -210px } .x-tool-down { BACKGROUND-POSITION: 0px -195px } .x-tool-down-over { BACKGROUND-POSITION: -15px -195px } .x-tool-refresh { BACKGROUND-POSITION: 0px -225px } .x-tool-refresh-over { BACKGROUND-POSITION: -15px -225px } .x-tool-minus { BACKGROUND-POSITION: 0px -255px } .x-tool-minus-over { BACKGROUND-POSITION: -15px -255px } .x-tool-plus { BACKGROUND-POSITION: 0px -240px } .x-tool-plus-over { BACKGROUND-POSITION: -15px -240px } .x-tool-search { BACKGROUND-POSITION: 0px -270px } .x-tool-search-over { BACKGROUND-POSITION: -15px -270px } .x-tool-save { BACKGROUND-POSITION: 0px -285px } .x-tool-save-over { BACKGROUND-POSITION: -15px -285px } .x-tool-help { BACKGROUND-POSITION: 0px -300px } .x-tool-help-over { BACKGROUND-POSITION: -15px -300px } .x-tool-print { BACKGROUND-POSITION: 0px -315px } .x-tool-print-over { BACKGROUND-POSITION: -15px -315px } .x-panel-ghost { Z-INDEX: 12000; BACKGROUND: #cbddf3; FILTER: alpha(opacity=3D65); LEFT: = 0px; OVERFLOW: hidden; POSITION: absolute; TOP: 0px; opacity: .65; = -moz-opacity: .65 } .x-panel-ghost UL { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #99bbe8 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; LINE-HEIGHT: 0; PADDING-TOP: 0px; BORDER-BOTTOM: #99bbe8 1px = solid } .x-panel-ghost * { CURSOR: move! important } .x-panel-dd-spacer { BORDER-RIGHT: #99bbe8 2px dashed; BORDER-TOP: #99bbe8 2px dashed; = BORDER-LEFT: #99bbe8 2px dashed; BORDER-BOTTOM: #99bbe8 2px dashed } .x-panel-btns-ct { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } .x-panel-btns-ct .x-btn { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns TD { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-btns-ct .x-panel-btns-right TABLE { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns-left TABLE { CLEAR: none; FLOAT: left } .x-panel-btns-ct .x-panel-btns-center { TEXT-ALIGN: center } .x-panel-btns-ct .x-panel-btns-center TABLE { MARGIN: 0px auto } .x-panel-btns-ct TABLE TD.x-panel-btn-td { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } .x-panel-btns-ct .x-btn-focus .x-btn-left { BACKGROUND-POSITION: 0px -147px } .x-panel-btns-ct .x-btn-focus .x-btn-right { BACKGROUND-POSITION: 0px -168px } .x-panel-btns-ct .x-btn-focus .x-btn-center { BACKGROUND-POSITION: 0px -189px } .x-panel-btns-ct .x-btn-over .x-btn-left { BACKGROUND-POSITION: 0px -63px } .x-panel-btns-ct .x-btn-over .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-over .x-btn-center { BACKGROUND-POSITION: 0px -105px } .x-panel-btns-ct .x-btn-click .x-btn-center { BACKGROUND-POSITION: 0px -126px } .x-panel-btns-ct .x-btn-click .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-click .x-btn-left { BACKGROUND-POSITION: 0px -63px } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/core/ext.ncbi/1/css/themes/xtheme-oldentrez.css .x-panel { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-STYLE: solid; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-STYLE: = solid; BORDER-LEFT-STYLE: solid; BORDER-RIGHT-COLOR: #d0d0d0; = BORDER-BOTTOM-STYLE: solid } .x-panel-header { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND-IMAGE: url(../../img/oldentrez/panel/white-top-bottom.gif); = BORDER-LEFT: #d0d0d0 1px solid; COLOR: #333; BORDER-BOTTOM: #d0d0d0 1px = solid } .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar-noheader .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-body-noheader { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tl .x-panel-header { COLOR: #333 } .x-panel-tc { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/top-bottom.gif) } .x-panel-tl { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(../../img/oldentrez/panel/corners-sprite.gif); BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tr { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/corners-sprite.gif) } .x-panel-bc { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/top-bottom.gif) } .x-panel-bl { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/corners-sprite.gif) } .x-panel-br { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/corners-sprite.gif) } .x-panel-mc { BACKGROUND: #f1f1f1 } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/left-right.gif) } .x-panel-mr { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/left-right.gif) } .x-tool { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/tool-sprites.gif) } .x-panel-ghost { BACKGROUND: #e0e0e0 } .x-panel-ghost UL { BORDER-LEFT-COLOR: #b0b0b0; BORDER-BOTTOM-COLOR: #b0b0b0; = BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-grid-panel .x-panel-mc .x-panel-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #d0d0d0 1px solid } .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/button/btn-sprite.gif) } .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/button/btn-sprite.gif) } .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/button/btn-sprite.gif) } .x-border-layout-ct { BACKGROUND: #f0f0f0 } .x-accordion-hd { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/light-hd.gif) } .x-layout-collapsed { BORDER-LEFT-COLOR: #e0e0e0; BORDER-BOTTOM-COLOR: #e0e0e0; = BORDER-TOP-COLOR: #e0e0e0; BACKGROUND-COLOR: #eee; BORDER-RIGHT-COLOR: = #e0e0e0 } .x-layout-collapsed-over { BACKGROUND-COLOR: #fbfbfb } .x-tip .x-tip-top { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-left { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-right { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-left { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-right { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-left { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-right { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(../../img/oldentrez/toolbar/bg.gif) #f0f4f5 repeat-x left top; = BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-toolbar BUTTON { COLOR: #444 } .x-toolbar .x-btn-menu-arrow-wrap .x-btn-center BUTTON { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-text-icon .x-btn-menu-arrow-wrap .x-btn-center BUTTON = { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-over .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over BUTTON { COLOR: #111 } .x-toolbar .x-btn-click .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .ytb-sep { BACKGROUND-IMAGE: url(../images/default/grid/grid-split.gif) } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-top { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(../../img/oldentrez/tabs/tab-strip-bg.gif) #dbdbdb repeat-x left = top; BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = PADDING-TOP: 2px; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-bottom { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/tab-strip-btm-bg.gif); BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-strip SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-over SPAN.x-tab-strip-text { COLOR: #111 } .x-tab-strip-active SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-disabled .x-tabs-text { COLOR: #aaaaaa } .x-tab-strip-top .x-tab-right { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-left { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-strip-inner { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-bottom .x-tab-right { BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/tab-btm-inactive-right-bg.gif) } .x-tab-strip-bottom .x-tab-left { BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/tab-btm-inactive-left-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-right { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-btm-right-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-left { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-btm-left-bg.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-close.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close:hover { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-close.gif) } .x-tab-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #fff; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header-plain .x-tab-strip-spacer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-scroller-left { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/scroll-left.gif); BORDER-BOTTOM-COLOR: = #aeaeae; BORDER-TOP-COLOR: #aeaeae; BORDER-RIGHT-COLOR: #aeaeae } .x-tab-scroller-right { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/scroll-right.gif); BORDER-BOTTOM-COLOR: = #aeaeae; BORDER-TOP-COLOR: #aeaeae; BORDER-RIGHT-COLOR: #aeaeae } .x-window-proxy { BORDER-LEFT-COLOR: #b0b0b0; BACKGROUND: #e0e0e0; BORDER-BOTTOM-COLOR: = #b0b0b0; BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-window-tl .x-window-header { COLOR: #555 } .x-window-tc { BACKGROUND-IMAGE: url(../../img/oldentrez/window/top-bottom.png) } .x-window-tl { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-corners.png) } .x-window-tr { BACKGROUND-IMAGE: url(../../img/oldentrez/window/right-corners.png) } .x-window-bc { BACKGROUND-IMAGE: url(../../img/oldentrez/window/top-bottom.png) } .x-window-bl { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-corners.png) } .x-window-br { BACKGROUND-IMAGE: url(../../img/oldentrez/window/right-corners.png) } .x-window-mc { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: = #d0d0d0 1px solid } .x-window-ml { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-right.png) } .x-window-mr { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-right.png) } .x-panel-ghost .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-collapsed .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-window-plain .x-window-mc { BORDER-RIGHT: #eee 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #eee = 1px solid } .x-window-plain .x-window-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #eee 1px solid; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-LEFT: #eee 1px = solid; BORDER-BOTTOM: #d0d0d0 1px solid } BODY.x-body-masked .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } BODY.x-body-masked .x-window-plain .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } .x-html-editor-wrap { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-noborder .x-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-noborder .x-window-mc { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-plain .x-window-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-footer-noborder { BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: = 0px } .x-tab-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-header { FONT-SIZE: 90%; FONT-FAMILY: Arial, Verdana, Sans-Serif; = BACKGROUND-COLOR: #e3e3e3; xbackground: none } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/portal/portalrc.fcgi/36264/css/36265/35466.css #footer { LINE-HEIGHT: 1.8em; FONT-FAMILY: "Helvetica Neue", GillSans, helvetica, = "lucida sans", arial, sans-serif } #footer H3 { FONT-SIZE: 1.1em } .foot_list H3 { FONT-SIZE: 1.1em } #footer { FONT-SIZE: 1.1em } #footer-contents-right { FLOAT: right; TEXT-ALIGN: right; _margin-top: 1em } #footer-contents-right A { PADDING-LEFT: 2px; FLOAT: left; OVERFLOW: hidden; WIDTH: 50px; = TEXT-INDENT: 10em; PADDING-TOP: 14px; HEIGHT: 41px } #footer-contents-right A.nih_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/nih_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 48px } #footer-contents-right A.nlm_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/nlm_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 50px } #footer-contents-right A.dhhs_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/dhhs_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 49px } #footer-contents-right A.usagov_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/usagov_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 94px } #footer-contents-left { =09 } #footer-contents-left P.address { MARGIN: 0px; PADDING-TOP: 1px } #footer-contents-left P.updateinfo { MARGIN: 1px; PADDING-TOP: 12px; TEXT-ALIGN: right } #footer-contents-left A { FONT-WEIGHT: bold } #footer-contents-left P.address .adr { DISPLAY: block } #footer-contents-left P.address .url { FONT-WEIGHT: normal; MARGIN: 0px } #footer { CLEAR: both; BACKGROUND: url(/portal/portalrc.fcgi/36264/img/31298) = #e5e5e5 repeat-x left top; ZOOM: 1; POSITION: relative; TOP: 2.5em; = _margin-top: -4em } #footer A { COLOR: #14376c; TEXT-DECORATION: none } #footer A:hover { TEXT-DECORATION: underline; BORDER-BOTTOM-STYLE: none } .contact_info A:hover { TEXT-DECORATION: underline; BORDER-BOTTOM-STYLE: none } .crest { BACKGROUND: url(/portal/portalrc.fcgi/36264/img/31299) no-repeat left = top; LEFT: 46.8%; WIDTH: 50px; POSITION: absolute; TOP: -2.3em; HEIGHT: = 50px; _background-image: none } #footer { OVERFLOW: visible; COLOR: #14376c; BACKGROUND-COLOR: #fff; TEXT-ALIGN: = center } .contact_info { OVERFLOW: visible; COLOR: #14376c; BACKGROUND-COLOR: #fff; TEXT-ALIGN: = center } .foot_list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4em 0px 0px; WIDTH: 19%; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } .foot_list LI H3 { MARGIN: 0px 0px 0.05em; TEXT-TRANSFORM: uppercase } .contact_info { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 1.6em; BACKGROUND: = url(/portal/portalrc.fcgi/36264/img/31297) repeat-y left top; = PADDING-BOTTOM: 0.6em; PADDING-TOP: 0.3em; ZOOM: 1; POSITION: relative; = TOP: 0.6em; TEXT-ALIGN: left; _padding-bottom: 5em } .breadcrumbs { LEFT: 1.6em; POSITION: absolute; TOP: 1.1em } .help_desk { RIGHT: 1em; POSITION: absolute; TOP: 1.1em } .subfooter { MARGIN-LEFT: 1.6em } .offscreen_noflow { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; TEXT-INDENT: -9999em; PADDING-TOP: 0px; HEIGHT: 0px } #footer { MARGIN-BOTTOM: 6em } .universal_header .inline_list LI A { FONT-SIZE: 1.2em } .myncbi A { FONT-SIZE: 1.2em } .universal_header { FONT-FAMILY: "Helvetica Neue", GillSans, helvetica, "lucida sans", = arial, sans-serif; HEIGHT: 2.7em; BACKGROUND-COLOR: #369; _font-size: = 1em } UL.resources_list { MARGIN-LEFT: 1.3em } .myncbi A { COLOR: #fff; TEXT-DECORATION: none } .myncbi A:hover { TEXT-DECORATION: underline } #ncbihome:focus { BACKGROUND: none transparent scroll repeat 0% 0% } .myncbi { RIGHT: 1em; FLOAT: right; COLOR: #fff; POSITION: relative; TOP: 0.3em } #ncbihome { PADDING-RIGHT: 0.8em; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #fff; PADDING-TOP: 0.25em } BODY UL.jig-ncbimenu A:focus { =09 } UL.jig-ncbimenu A.topanchor { COLOR: #fff } UL.jig-ncbimenu A:hover { TEXT-DECORATION: none } .ui-ncbimenu-item-no-hlt { =09 } DIV.universal_header UL.jig-ncbimenu LI A { FONT-SIZE: 1.09em } .ui-ncbimenu-item { BORDER-BOTTOM: #e5e5e5 1px dotted; BACKGROUND-COLOR: #fcfcfc } .ui-ncbimenu LI.ui-ncbimenu-item-first = A.ui-ncbimenu-first-link-has-submenu { PADDING-RIGHT: 20px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0.2em; = PADDING-TOP: 0.5em } BODY UL.ui-ncbimenu-submenu { BORDER-RIGHT: #aaa 1px solid; BORDER-TOP: #ddd 1px solid; BORDER-LEFT: = #ddd 1px solid; BORDER-BOTTOM: #aaa 1px solid; box-shadow: .4em .4em = .5em #bbb; -webkit-box-shadow: .4em .4em .5em #bbb; -moz-box-shadow: = .4em .4em .5em #bbb } BODY .ui-ncbimenu-item-first-active { COLOR: #fff; BACKGROUND-COLOR: #4c96df } BODY UL LI A.ui-ncbimenu-item-active { COLOR: #fff; BACKGROUND-COLOR: #4c96df } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/portal/portalrc.fcgi/37359/css/37044/37050/25667/26519/22392/22398/25875/17551/22162/22394/28890/29899/17591/26330/25569/29286/37113/37051/27687.css BODY { =09 } #pagewrap { MARGIN: auto; WIDTH: 960px; xborder: solid 1px red } #page { FONT-SIZE: 11pt; MARGIN: 1em } #footer { CLEAR: both; MIN-WIDTH: 800px; FONT-SIZE: 70%; PADDING-TOP: 1em } #pmc-home-hdr { HEIGHT: 73px } #pmc-home-hdr #homelink { FLOAT: left } #pmc-home-hdr #homelink IMG { BORDER-TOP-STYLE: none; BORDER-RIGHT-STYLE: none; BORDER-LEFT-STYLE: = none; BORDER-BOTTOM-STYLE: none } #pmc-home-hdr H1 { MARGIN: 0px 0px 0px 144px; ZOOM: 1; FONT-FAMILY: Arial, Verdana, = Sans-Serif; POSITION: relative; TOP: -1px; BACKGROUND-COLOR: #3c78bc } #pmc-home-hdr UL { MARGIN: 0px 0px 0px 144px; ZOOM: 1; FONT-FAMILY: Arial, Verdana, = Sans-Serif; POSITION: relative; TOP: -1px; BACKGROUND-COLOR: #3c78bc } #pmc-home-hdr H1 { PADDING-RIGHT: 2em; BORDER-TOP: transparent 2px solid; FONT-SIZE: 2em; = COLOR: white; LINE-HEIGHT: 52px; TEXT-ALIGN: right } #pmc-home-hdr UL { BORDER-RIGHT: #3c78bc 1px solid; BORDER-BOTTOM: #3c78bc 3px solid; = HEIGHT: 18px; BACKGROUND-COLOR: #a0c0e0 } #pmc-home-hdr UL LI { PADDING-RIGHT: 40px; DISPLAY: inline; PADDING-LEFT: 40px; FONT-SIZE: = 1.3em; PADDING-BOTTOM: 0px; MARGIN: 0px; LINE-HEIGHT: 18px; PADDING-TOP: = 0px; LIST-STYLE-TYPE: none } #pmc-home-hdr UL LI A { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 2px; = PADDING-TOP: 2px; TEXT-DECORATION: none } #pmc-home-hdr UL LI A:hover { TEXT-DECORATION: underline } A:visited { COLOR: #7119b4 } #pmc-home-hdr UL LI.sel A { FONT-WEIGHT: bold; COLOR: white; BACKGROUND-COLOR: #3c78bc; = TEXT-DECORATION: none } #pmc-home-hdr UL LI.sel A:visited { FONT-WEIGHT: bold; COLOR: white; BACKGROUND-COLOR: #3c78bc; = TEXT-DECORATION: none } #pmc-home-hdr UL LI.sel A:hover { FONT-WEIGHT: bold; COLOR: white; BACKGROUND-COLOR: #3c78bc; = TEXT-DECORATION: none } .footer-section { MARGIN: 0px 1em 1em; TEXT-ALIGN: center } BODY #cols { BORDER-RIGHT: transparent 1px solid; BORDER-TOP: transparent 1px solid; = BORDER-LEFT: transparent 1px solid; BORDER-BOTTOM: transparent 1px solid } @media Print =20 { .footer { DISPLAY: none } TD.pmc-watermark { MIN-WIDTH: 0px; WIDTH: 0px } } .nopagesectioncontent { DISPLAY: none } .port { FONT-SIZE: 1em } .port { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port PRE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port FIELDSET { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port INPUT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port BLOCKQUOTE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port TH { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port TD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .port OL { LIST-STYLE-TYPE: none } .port UL { LIST-STYLE-TYPE: none } .x-unselectable { -moz-user-select: none; -khtml-user-select: none } .x-unselectable * { -moz-user-select: none; -khtml-user-select: none } .x-panel { BORDER-RIGHT: #99bbe8 0px solid; BORDER-TOP: #99bbe8 0px solid; = BORDER-LEFT: #99bbe8 0px solid; BORDER-BOTTOM: #99bbe8 0px solid } .x-panel-header { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #99bbe8 1px solid; PADDING-LEFT: 5px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/white-top-bottom.g= if) repeat-x 0px -1px; PADDING-BOTTOM: 4px; FONT: bold 11px/15px = tahoma,arial,verdana,sans-serif; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: #99bbe8 1px = solid; ZOOM: 1 } .x-panel-body { BORDER-RIGHT: #99bbe8 1px solid; BORDER-TOP: #99bbe8 0px; BACKGROUND: = white; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 1px solid; BORDER-BOTTOM: = #99bbe8 1px solid; POSITION: relative } .x-panel-bbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar-noheader .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-body-noheader { BORDER-TOP: #99bbe8 1px solid } .x-panel-mc .x-panel-body { BORDER-TOP: #99bbe8 1px solid } .x-panel-header { OVERFLOW: hidden; ZOOM: 1 } .x-panel-tl .x-panel-header { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: none transparent scroll repeat 0% 0%; PADDING-BOTTOM: = 4px; FONT: bold 11px tahoma,arial,verdana,sans-serif; BORDER-LEFT: 0px; = COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: 0px } .x-panel-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-window-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-panel-inline-icon { BACKGROUND-POSITION: 0px 0px; MARGIN-TOP: -1px; MARGIN-BOTTOM: -1px; = VERTICAL-ALIGN: middle; WIDTH: 16px; MARGIN-RIGHT: 4px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px } .x-panel-tc { BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/top-bottom.gif) = repeat-x 0px 0px; OVERFLOW: hidden } .ext-strict .ext-ie7 .x-panel-tc { OVERFLOW: visible } .x-panel-tl { PADDING-LEFT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat 0px 0px; BORDER-BOTTOM: #99bbe8 1px solid; ZOOM: 1 } .x-panel-tr { PADDING-RIGHT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat right 0px; ZOOM: 1 } .x-panel-bc { BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/top-bottom.gif) = repeat-x 0px bottom; ZOOM: 1 } .x-panel-bc .x-panel-footer { ZOOM: 1 } .x-panel-bl { PADDING-LEFT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat 0px bottom; ZOOM: 1 } .x-panel-br { PADDING-RIGHT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat right bottom; ZOOM: 1 } .x-panel-mc { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: #dfe8f6; PADDING-BOTTOM: 0px; MARGIN: 0px; FONT: 11px = tahoma,arial,helvetica,sans-serif; BORDER-LEFT: 0px; PADDING-TOP: 6px; = BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { PADDING-LEFT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/left-right.gif) = #fff repeat-y 0px 0px; ZOOM: 1 } .x-panel-mr { PADDING-RIGHT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/left-right.gif) = repeat-y right 0px; ZOOM: 1 } .x-panel-bc .x-panel-footer { PADDING-BOTTOM: 6px } .x-panel-nofooter .x-panel-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-nofooter .x-window-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-bwrap { OVERFLOW: hidden; ZOOM: 1 } .x-panel-body { OVERFLOW: hidden; ZOOM: 1 } .x-panel-collapsed .x-resizable-handle { DISPLAY: none } .ext-gecko .x-panel-animated DIV { OVERFLOW: hidden! important } .x-plain-body { OVERFLOW: hidden } .x-plain-bbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-tbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-bwrap { OVERFLOW: hidden; ZOOM: 1 } .x-plain { OVERFLOW: hidden } .x-tool { BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/tool-sprites.gif) = no-repeat; FLOAT: right; MARGIN-LEFT: 2px; OVERFLOW: hidden; WIDTH: = 15px; CURSOR: pointer; HEIGHT: 15px } .x-tool-toggle { BACKGROUND-POSITION: 0px -60px } .x-tool-toggle-over { BACKGROUND-POSITION: -15px -60px } .x-panel-collapsed .x-tool-toggle { BACKGROUND-POSITION: 0px -75px } .x-panel-collapsed .x-tool-toggle-over { BACKGROUND-POSITION: -15px -75px } .x-tool-close { BACKGROUND-POSITION: 0px 0px } .x-tool-close-over { BACKGROUND-POSITION: -15px 0px } .x-tool-minimize { BACKGROUND-POSITION: 0px -15px } .x-tool-minimize-over { BACKGROUND-POSITION: -15px 50% } .x-tool-maximize { BACKGROUND-POSITION: 0px -30px } .x-tool-maximize-over { BACKGROUND-POSITION: -15px -30px } .x-tool-restore { BACKGROUND-POSITION: 0px -45px } .x-tool-restore-over { BACKGROUND-POSITION: -15px -45px } .x-tool-gear { BACKGROUND-POSITION: 0px -90px } .x-tool-gear-over { BACKGROUND-POSITION: -15px -90px } .x-tool-pin { BACKGROUND-POSITION: 0px -135px } .x-tool-pin-over { BACKGROUND-POSITION: -15px -135px } .x-tool-unpin { BACKGROUND-POSITION: 0px -150px } .x-tool-unpin-over { BACKGROUND-POSITION: -15px -150px } .x-tool-right { BACKGROUND-POSITION: 0px -165px } .x-tool-right-over { BACKGROUND-POSITION: -15px -165px } .x-tool-left { BACKGROUND-POSITION: 0px -180px } .x-tool-left-over { BACKGROUND-POSITION: -15px -180px } .x-tool-up { BACKGROUND-POSITION: 0px -210px } .x-tool-up-over { BACKGROUND-POSITION: -15px -210px } .x-tool-down { BACKGROUND-POSITION: 0px -195px } .x-tool-down-over { BACKGROUND-POSITION: -15px -195px } .x-tool-refresh { BACKGROUND-POSITION: 0px -225px } .x-tool-refresh-over { BACKGROUND-POSITION: -15px -225px } .x-tool-minus { BACKGROUND-POSITION: 0px -255px } .x-tool-minus-over { BACKGROUND-POSITION: -15px -255px } .x-tool-plus { BACKGROUND-POSITION: 0px -240px } .x-tool-plus-over { BACKGROUND-POSITION: -15px -240px } .x-tool-search { BACKGROUND-POSITION: 0px -270px } .x-tool-search-over { BACKGROUND-POSITION: -15px -270px } .x-tool-save { BACKGROUND-POSITION: 0px -285px } .x-tool-save-over { BACKGROUND-POSITION: -15px -285px } .x-tool-help { BACKGROUND-POSITION: 0px -300px } .x-tool-help-over { BACKGROUND-POSITION: -15px -300px } .x-tool-print { BACKGROUND-POSITION: 0px -315px } .x-tool-print-over { BACKGROUND-POSITION: -15px -315px } .x-panel-ghost { Z-INDEX: 12000; BACKGROUND: #cbddf3; FILTER: alpha(opacity=3D65); LEFT: = 0px; OVERFLOW: hidden; POSITION: absolute; TOP: 0px; opacity: .65; = -moz-opacity: .65 } .x-panel-ghost UL { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #99bbe8 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; LINE-HEIGHT: 0; PADDING-TOP: 0px; BORDER-BOTTOM: #99bbe8 1px = solid } .x-panel-ghost * { CURSOR: move! important } .x-panel-dd-spacer { BORDER-RIGHT: #99bbe8 2px dashed; BORDER-TOP: #99bbe8 2px dashed; = BORDER-LEFT: #99bbe8 2px dashed; BORDER-BOTTOM: #99bbe8 2px dashed } .x-panel-btns-ct { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } .x-panel-btns-ct .x-btn { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns TD { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-btns-ct .x-panel-btns-right TABLE { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns-left TABLE { CLEAR: none; FLOAT: left } .x-panel-btns-ct .x-panel-btns-center { TEXT-ALIGN: center } .x-panel-btns-ct .x-panel-btns-center TABLE { MARGIN: 0px auto } .x-panel-btns-ct TABLE TD.x-panel-btn-td { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } .x-panel-btns-ct .x-btn-focus .x-btn-left { BACKGROUND-POSITION: 0px -147px } .x-panel-btns-ct .x-btn-focus .x-btn-right { BACKGROUND-POSITION: 0px -168px } .x-panel-btns-ct .x-btn-focus .x-btn-center { BACKGROUND-POSITION: 0px -189px } .x-panel-btns-ct .x-btn-over .x-btn-left { BACKGROUND-POSITION: 0px -63px } .x-panel-btns-ct .x-btn-over .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-over .x-btn-center { BACKGROUND-POSITION: 0px -105px } .x-panel-btns-ct .x-btn-click .x-btn-center { BACKGROUND-POSITION: 0px -126px } .x-panel-btns-ct .x-btn-click .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-click .x-btn-left { BACKGROUND-POSITION: 0px -63px } .x-btn-menu-wrap { WIDTH: 0px! important } .x-menu { BACKGROUND: #f0f0f0 0px 0px } .x-menu-list-item IMG { DISPLAY: none } .x-menu-list-item A.x-menu-item { PADDING-LEFT: 8px } .port H1.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H2.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H3.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H4.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H5.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H6.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } DIV.x-panel-body { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } .port .x-panel-header { PADDING-RIGHT: 3px; PADDING-LEFT: 5px; PADDING-BOTTOM: 4px; = PADDING-TOP: 5px } .x-panel { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-STYLE: solid; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-STYLE: = solid; BORDER-LEFT-STYLE: solid; BORDER-RIGHT-COLOR: #d0d0d0; = BORDER-BOTTOM-STYLE: solid } .x-panel-header { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/white-top-bottom.gif); = BORDER-LEFT: #d0d0d0 1px solid; COLOR: #333; BORDER-BOTTOM: #d0d0d0 1px = solid } .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar-noheader .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-body-noheader { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tl .x-panel-header { COLOR: #333 } .x-panel-tc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/top-bottom.gif) } .x-panel-tl { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif); = BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif) } .x-panel-bc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/top-bottom.gif) } .x-panel-bl { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif) } .x-panel-br { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif) } .x-panel-mc { BACKGROUND: #f1f1f1 } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/left-right.gif) } .x-panel-mr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/left-right.gif) } .x-tool { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/tool-sprites.gif) } .x-panel-ghost { BACKGROUND: #e0e0e0 } .x-panel-ghost UL { BORDER-LEFT-COLOR: #b0b0b0; BORDER-BOTTOM-COLOR: #b0b0b0; = BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-grid-panel .x-panel-mc .x-panel-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #d0d0d0 1px solid } .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/button/btn-sprite.gif) } .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/button/btn-sprite.gif) } .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/button/btn-sprite.gif) } .x-border-layout-ct { BACKGROUND: #f0f0f0 } .x-accordion-hd { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/light-hd.gif) } .x-layout-collapsed { BORDER-LEFT-COLOR: #e0e0e0; BORDER-BOTTOM-COLOR: #e0e0e0; = BORDER-TOP-COLOR: #e0e0e0; BACKGROUND-COLOR: #eee; BORDER-RIGHT-COLOR: = #e0e0e0 } .x-layout-collapsed-over { BACKGROUND-COLOR: #fbfbfb } .x-tip .x-tip-top { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/bg.gif) #f0f4f5 repeat-x left = top; BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-toolbar BUTTON { COLOR: #444 } .x-toolbar .x-btn-menu-arrow-wrap .x-btn-center BUTTON { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-text-icon .x-btn-menu-arrow-wrap .x-btn-center BUTTON = { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-over .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over BUTTON { COLOR: #111 } .x-toolbar .x-btn-click .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .ytb-sep { BACKGROUND-IMAGE: = url(/core/extjs/ext-2.1/resources/images/default/grid/grid-split.gif) } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-top { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-strip-bg.gif) #dbdbdb = repeat-x left top; BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: = #d0d0d0; PADDING-TOP: 2px; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-bottom { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-strip-btm-bg.gif); = BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-strip SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-over SPAN.x-tab-strip-text { COLOR: #111 } .x-tab-strip-active SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-disabled .x-tabs-text { COLOR: #aaaaaa } .x-tab-strip-top .x-tab-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-strip-inner { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-bottom .x-tab-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-inactive-right-bg.gif) } .x-tab-strip-bottom .x-tab-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-inactive-left-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-right-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-left-bg.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-close.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close:hover { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-close.gif) } .x-tab-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #fff; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header-plain .x-tab-strip-spacer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-scroller-left { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/scroll-left.gif); = BORDER-BOTTOM-COLOR: #aeaeae; BORDER-TOP-COLOR: #aeaeae; = BORDER-RIGHT-COLOR: #aeaeae } .x-tab-scroller-right { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/scroll-right.gif); = BORDER-BOTTOM-COLOR: #aeaeae; BORDER-TOP-COLOR: #aeaeae; = BORDER-RIGHT-COLOR: #aeaeae } .x-window-proxy { BORDER-LEFT-COLOR: #b0b0b0; BACKGROUND: #e0e0e0; BORDER-BOTTOM-COLOR: = #b0b0b0; BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-window-tl .x-window-header { COLOR: #555 } .x-window-tc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/top-bottom.png) } .x-window-tl { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-corners.png) } .x-window-tr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/right-corners.png) } .x-window-bc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/top-bottom.png) } .x-window-bl { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-corners.png) } .x-window-br { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/right-corners.png) } .x-window-mc { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: = #d0d0d0 1px solid } .x-window-ml { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-right.png) } .x-window-mr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-right.png) } .x-panel-ghost .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-collapsed .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-window-plain .x-window-mc { BORDER-RIGHT: #eee 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #eee = 1px solid } .x-window-plain .x-window-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #eee 1px solid; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-LEFT: #eee 1px = solid; BORDER-BOTTOM: #d0d0d0 1px solid } BODY.x-body-masked .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } BODY.x-body-masked .x-window-plain .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } .x-html-editor-wrap { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-noborder .x-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-noborder .x-window-mc { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-plain .x-window-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-footer-noborder { BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: = 0px } .x-tab-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-header { FONT-SIZE: 90%; FONT-FAMILY: Arial, Verdana, Sans-Serif; = BACKGROUND-COLOR: #e3e3e3; xbackground: none } DIV.section.port { MARGIN-TOP: 0.5em; PADDING-TOP: 0.5em; FONT-FAMILY: = Arial,Helvetica,Sans-Serif } DIV.x-panel-body DIV.section.port { MARGIN-TOP: 0px; PADDING-TOP: 0px } DIV.section.port DIV.window { PADDING-LEFT: 0.5em; MARGIN-BOTTOM: 0.5em } DIV.port LI.item EM.error.linklist { FONT-SIZE: 1.2em; COLOR: #cc0000; BACKGROUND-COLOR: #eaebc8 } DIV.norender.port { FONT-FAMILY: Arial,Lucida Sans,Trebuchet,Sans-Serif } DIV.brieflink { MARGIN-TOP: 0.5em; PADDING-TOP: 0.5em; FONT-FAMILY: Arial, Lucida Sans, = Trebuchet, Sans-Serif } DIV.brieflink H2 { FONT-WEIGHT: bold; FONT-SIZE: 0.8em; PADDING-BOTTOM: 0.3em; = MARGIN-LEFT: 0.2em; COLOR: #000000 } DIV.brieflink DIV { BORDER-TOP: #bdbdbd 1px solid } DIV.brieflink UL { FONT-SIZE: 0.8em; COLOR: #212121 } DIV.brieflink UL LI.item { BACKGROUND-POSITION: 0px 0.35em; PADDING-LEFT: 1.2em; MIN-HEIGHT: = 1.25em; BACKGROUND-IMAGE: url(/portal/portalrc.fcgi/37359/img/28247); = MARGIN: 0.25em 0px 0px; OVERFLOW: hidden; MAX-HEIGHT: 2.5em; = LINE-HEIGHT: 1.25em; PADDING-TOP: 0.1em; BACKGROUND-REPEAT: no-repeat; = ZOOM: 1; POSITION: relative } DIV.brieflink UL LI.note.item { HEIGHT: 2.5em } DIV.brieflink UL LI.more { MARGIN-TOP: 0.5em; PADDING-TOP: 0.1em; WHITE-SPACE: nowrap; TEXT-ALIGN: = right; BORDER-BOTTOM-STYLE: none } DIV.brieflink UL LI.item A { FLOAT: left; OVERFLOW: hidden; COLOR: #212121; MAX-HEIGHT: 2.5em; = TEXT-DECORATION: none; BORDER-BOTTOM-STYLE: none } DIV.brieflink UL LI.more A { COLOR: #212121; TEXT-DECORATION: none; BORDER-BOTTOM-STYLE: none } DIV.brieflink UL LI A:hover { TEXT-DECORATION: underline; _border-bottom: none } DIV.brieflink LI.item P.desc { LEFT: 1000px; BOTTOM: 1000px; LINE-HEIGHT: 0; POSITION: relative; = HEIGHT: 0px } DIV.brieflink UL LI.item P.note { DISPLAY: inline; PADDING-LEFT: 0.2em; RIGHT: 0px; OVERFLOW: hidden; = COLOR: #666666; WHITE-SPACE: nowrap; POSITION: absolute; TOP: 1.3em; = BACKGROUND-COLOR: white } DIV.brieflink LI.footer { BORDER-TOP: #bdbdbd 1px solid; MARGIN-TOP: 0.4em; FONT-SIZE: 0.9em; = MARGIN-LEFT: 1.5em; COLOR: #666666; LINE-HEIGHT: 1.5em; TEXT-ALIGN: = right } .poptext { DISPLAY: none } .popper { DISPLAY: none; Z-INDEX: 1000; MARGIN: 0px; WIDTH: 300px; ZOOM: 1; = POSITION: absolute } .pop-getxy { DISPLAY: none; Z-INDEX: 1000; MARGIN: 0px; WIDTH: 300px; ZOOM: 1; = POSITION: absolute } .port { ZOOM: 1! important } .pop-getxy { VISIBILITY: hidden } .popped.popper { DISPLAY: block; BACKGROUND-COLOR: #fff } DIV.pop-left.popped.popper DIV.popperInnerDiv { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 0px } DIV.pop-right.popped.popper DIV.popperInnerDiv { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; MARGIN-RIGHT: 0px } DIV.pop-above.popped.popper DIV.popperInnerDiv { MARGIN-TOP: 0px; MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } DIV.pop-below.popped.popper DIV.popperInnerDiv { MARGIN-BOTTOM: 0px; MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } .popper { FONT-SIZE: 0.8em; WIDTH: 30em; COLOR: #222; FONT-FAMILY: Arial, Lucida = Sans, Trebuchet, Sans-Serif } .popped.popper { BACKGROUND: url(/portal/portalrc.fcgi/37359/img/17684) no-repeat center = center; xbackground: transparent = url(http://iwebdev/staff/mjohnson/proj/components/popper/pop2.png) = no-repeat center center } .popped.popper DIV.popperInnerDiv { BORDER-RIGHT: #369 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #369 = 1px solid; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; MARGIN: 15px; = BORDER-LEFT: #369 1px solid; PADDING-TOP: 0.5em; BORDER-BOTTOM: #369 1px = solid; BACKGROUND-COLOR: #f0f8ff } DIV#popContent DIV.popperInnerDiv { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; FONT-SIZE: 80%; Z-INDEX: 5; = PADDING-BOTTOM: 0.5em; COLOR: #444444; PADDING-TOP: 0.5em; FONT-FAMILY: = Verdana, Arial, sans-serif; BACKGROUND-COLOR: #f0f8ff; opacity: 1 } DIV.pop-left.popped.popper { BACKGROUND-POSITION: 100% -12px } DIV.pop-right.popped.popper { BACKGROUND-POSITION: 0px -12px } DIV.pop-above.popped.popper { BACKGROUND-POSITION: -12px 100% } DIV.pop-below.popped.popper { BACKGROUND-POSITION: -12px 0px } DIV.section DIV.window.brieflink { MARGIN-TOP: 0.75em; PADDING-TOP: 0px } DIV.window.brieflink UL LI.item { HEIGHT: auto } DIV#HTDisplay { FONT-FAMILY: Arial,sans-serif } DIV#HTDisplay A { COLOR: #232323; BORDER-TOP-STYLE: none; BORDER-RIGHT-STYLE: none; = BORDER-LEFT-STYLE: none; TEXT-DECORATION: underline; = BORDER-BOTTOM-STYLE: none } DIV#HTDisplay UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 80%; PADDING-BOTTOM: = 0px; MARGIN: 1.3em 0em 1em; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = _padding-top: 1.3em } DIV#HTDisplay UL LI { PADDING-RIGHT: 0.2em; PADDING-LEFT: 1.8em; MARGIN: 0.8em 0.3em 0.8em = 0.7em; OVERFLOW: hidden; COLOR: #232323; MAX-HEIGHT: 2.6em; POSITION: = relative; HEIGHT: auto } DIV#HTDisplay UL LI.query { MIN-HEIGHT: 15px; BACKGROUND: = url(/portal/portalrc.fcgi/37359/img/16134) no-repeat 0px 0px } DIV#HTDisplay UL LI.query DIV.textwrapper { MAX-WIDTH: 85% } DIV#HTDisplay UL LI.record { BACKGROUND: url(/portal/portalrc.fcgi/37359/img/16133) no-repeat 0px = 20%; LINE-HEIGHT: 1.3 } DIV#HTDisplay UL LI.bottomline { PADDING-BOTTOM: 0.3em; BORDER-BOTTOM: #999999 1px solid } DIV#HTDisplay UL LI A.hidden { DISPLAY: none } DIV#HTDisplay UL LI.record A { TEXT-DECORATION: none } DIV#HTDisplay UL LI.record A:hover { TEXT-DECORATION: underline } DIV#HTDisplay UL .count { LEFT: 0.3em; POSITION: relative; TOP: 1px } DIV#HTDisplay DIV.action { OVERFLOW: hidden } DIV#HTDisplay DIV.action A { FONT-SIZE: 75%; FLOAT: right; MARGIN: 0em 0.5em 0.25em } DIV#HTDisplay P { CLEAR: both; FONT-SIZE: 85%; MARGIN: 1.2em 0em 0.6em 0.5em } DIV#HTDisplay UL LI .thumb { RIGHT: 0px; PADDING-TOP: 0.4em; POSITION: absolute; BACKGROUND-COLOR: = white; _padding-right: 0.4em } DIV#HTDisplay P { DISPLAY: none } DIV#HTDisplay .action A.HTOff { DISPLAY: none } DIV.HTOff#HTDisplay .action A.HTOn { DISPLAY: none } DIV.HTOff#HTDisplay P.HTOff { DISPLAY: block } DIV.HTOn#HTDisplay P.HTOn { DISPLAY: block } DIV.HTOff#HTDisplay .action A.HTOff { DISPLAY: block } DIV.HTOn#HTDisplay .action A.HTOn { DISPLAY: block } DIV#HTDisplay UL.hide { DISPLAY: none } IMG.htbpoparrow { Z-INDEX: 4; BACKGROUND: url(/corehtml/query/PubMed/right.jpg) no-repeat = right top; LEFT: 22px; FLOAT: right; ZOOM: 1; POSITION: relative; TOP: = -7px; _left: 25px } DIV#htbpopper { BORDER-RIGHT: #369 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #369 = 1px solid; DISPLAY: block; PADDING-LEFT: 0.5em; FONT-SIZE: 80%; Z-INDEX: = 5; PADDING-BOTTOM: 0.5em; BORDER-LEFT: #369 1px solid; WIDTH: 32em; = COLOR: #444; PADDING-TOP: 0.5em; BORDER-BOTTOM: #369 1px solid; ZOOM: 1; = FONT-FAMILY: Verdana; POSITION: absolute; BACKGROUND-COLOR: #f0f8ff; = opacity: 100 } DIV.popper P { MARGIN: 0px 0px 0.25em } P#htbpcit { DISPLAY: block; FONT-SIZE: 85% } P.pmid { DISPLAY: block; FONT-SIZE: 85% } P#htbpcit { FONT-STYLE: italic } .hidden#htbpopper { DISPLAY: none } DIV#HTDisplay UL LI SPAN.thumb { BACKGROUND-COLOR: #f8f8f8 } #content UL.DiscoverySection { =09 } #content LI.DiscoverySectionTitle { FONT-WEIGHT: bold; PADDING-BOTTOM: 0.2em; COLOR: #1356d8; PADDING-TOP: = 1em; BORDER-BOTTOM: #cccccc 1px solid } #content LI.DiscoveryItem { PADDING-LEFT: 1.2em; FONT-SIZE: 0.9em; BACKGROUND: = url(/portal/portalrc.fcgi/15049/img/15679) no-repeat left top; = PADDING-BOTTOM: 0.3em } #content LI.DiscoveryItem A { COLOR: #232323; BORDER-BOTTOM-STYLE: none } UNKNOWN { TEXT-DECORATION: underline } #content LI.DiscoveryAllLinks { FONT-SIZE: 0.9em; PADDING-BOTTOM: 0.3em; BORDER-BOTTOM: #cccccc 1px = solid; TEXT-ALIGN: right } #content LI.DiscoveryAllLinks A { COLOR: #cc0000; TEXT-DECORATION: underline } DIV.popper EM.cit { MARGIN-TOP: 0.5em; DISPLAY: block; FONT-SIZE: 0.85em; FONT-STYLE: = italic } DIV.popper EM.author { MARGIN-TOP: 0.5em; DISPLAY: block; FONT-SIZE: 0.85em; MARGIN-BOTTOM: = -0.3em; FONT-STYLE: normal } DIV.Pubmed_Discovery_RA SPAN.reviewflag { PADDING-RIGHT: 0.1em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; FONT-SIZE: 0.9em; FLOAT: left; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: middle; COLOR: white; MARGIN-RIGHT: 0.5em; PADDING-TOP: = 0px; FONT-STYLE: italic; BACKGROUND-COLOR: #a81b0e } DIV.popper SPAN.reviewflag { DISPLAY: none } DIV.PPMCPubmedRA SPAN.reviewflag { PADDING-RIGHT: 0.1em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; FONT-SIZE: 0.9em; FLOAT: left; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: middle; COLOR: white; MARGIN-RIGHT: 0.5em; PADDING-TOP: = 0px; FONT-STYLE: italic; BACKGROUND-COLOR: #a81b0e } DIV.popper SPAN.reviewflag { DISPLAY: none } BODY #col1 { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #col2 { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #subheader { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #subfooter { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #subfooter { TEXT-ALIGN: center } #Table2 { WIDTH: 100%; BACKGROUND-COLOR: #ecf0f4 } #Table3 { =09 } TD.pmc-watermark { MIN-WIDTH: 20px } TD.format-menu { PADDING-RIGHT: 0px; PADDING-LEFT: 0.75em; FONT-SIZE: 80%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } TD.format-menu UL { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0.25em; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 0.2em; PADDING-TOP: 0px } TD.format-menu H2 { DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 1em; COLOR: #000 } TD.format-menu UL LI { DISPLAY: inline; MARGIN: 0px 0.1em 0px 0px } TD.format-menu UL LI A { COLOR: #000000 } TD.format-menu UL LI.selected { COLOR: #5e5e5e } TD.content-cell { MIN-WIDTH: 550px; WIDTH: 550px } TD.content-cell > DIV TD.content-cell > DIV > DIV { ZOOM: 1 } TD.sidebar-cell { MIN-WIDTH: 250px; MAX-WIDTH: 350px; WIDTH: 350px } BODY.pmc-body #Table3 DIV.navlink-box { FONT-WEIGHT: normal; WIDTH: auto; BORDER-BOTTOM: #5e5e5e 1px solid } DIV.cited-ref { MIN-WIDTH: 250px; MAX-WIDTH: 350px; MARGIN: 0.3em 0.75em; WIDTH: 350px; = POSITION: absolute } DIV.section-content > DIV.p { WIDTH: 550px; WORD-WRAP: break-word } DIV.sec { WIDTH: 550px } IMG.equation { MAX-WIDTH: 502px; ; WIDTH: expression(this.clientWidth - 2 < 500? = "auto" : "502px") } DIV.section-content DIV.figure-table-caption-in-article DIV.p { WIDTH: auto } DIV.ArticleRefDocsums { =09 } DIV.pmlinks UL.links { PADDING-RIGHT: 0px; LIST-STYLE: none none outside; BORDER-TOP: #cccccc = 1px solid; DISPLAY: block; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; FONT-FAMILY: Arial,Helvetica,sans-serif } DIV.cited-ref UL { PADDING-RIGHT: 0px; LIST-STYLE: none none outside; BORDER-TOP: #cccccc = 1px solid; DISPLAY: block; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; FONT-FAMILY: Arial,Helvetica,sans-serif } DIV.pmlinks UL.links LI.ovfl { DISPLAY: block; FONT-SIZE: 80%; BACKGROUND: = url(/portal/portalrc.fcgi/37359/img/28247) no-repeat left top; MARGIN: = 0.75em 0.2em 0px 0px; OVERFLOW: hidden; WIDTH: 100%; LINE-HEIGHT: 1.2em; = ZOOM: 1; POSITION: relative } DIV.cited-ref LI.ovfl { DISPLAY: block; FONT-SIZE: 80%; BACKGROUND: = url(/portal/portalrc.fcgi/37359/img/28247) no-repeat left top; MARGIN: = 0.75em 0.2em 0px 0px; OVERFLOW: hidden; WIDTH: 100%; LINE-HEIGHT: 1.2em; = ZOOM: 1; POSITION: relative } DIV.pmlinks UL.links LI.ovfl A.pl { DISPLAY: block; PADDING-LEFT: 1.5em; OVERFLOW: hidden; COLOR: = rgb(35,35,35); HEIGHT: 2.4em; TEXT-DECORATION: none } DIV.cited-ref LI.ovfl A.pl { DISPLAY: block; PADDING-LEFT: 1.5em; OVERFLOW: hidden; COLOR: = rgb(35,35,35); HEIGHT: 2.4em; TEXT-DECORATION: none } DIV.pmlinks UL.links LI.ovfl A.pl:hover { TEXT-DECORATION: underline } DIV.cited-ref LI.ovfl A.pl:hover { TEXT-DECORATION: underline } DIV.pmlinks UL.links LI.ovfl SPAN.pub { PADDING-RIGHT: 0.5em; MARGIN-TOP: 0.2em; DISPLAY: block; PADDING-LEFT: = 0.5em; Z-INDEX: 4; RIGHT: 0px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = COLOR: #666; BOTTOM: -0.2em; PADDING-TOP: 0px; ZOOM: 1; FONT-FAMILY: = Verdana,Arial,Sans-Serif; WHITE-SPACE: nowrap; LETTER-SPACING: -1px; = POSITION: absolute; BACKGROUND-COLOR: #f8f8f8 } DIV.cited-ref LI.ovfl SPAN.pub { PADDING-RIGHT: 0.5em; MARGIN-TOP: 0.2em; DISPLAY: block; PADDING-LEFT: = 0.5em; Z-INDEX: 4; RIGHT: 0px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = COLOR: #666; BOTTOM: -0.2em; PADDING-TOP: 0px; ZOOM: 1; FONT-FAMILY: = Verdana,Arial,Sans-Serif; WHITE-SPACE: nowrap; LETTER-SPACING: -1px; = POSITION: absolute; BACKGROUND-COLOR: #f8f8f8 } DIV.pmlinks UL.links LI.ovfl SPAN.flag { PADDING-RIGHT: 0.3em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; PADDING-BOTTOM: 0px; VERTICAL-ALIGN: middle; COLOR: = white; MARGIN-RIGHT: 0.5em; PADDING-TOP: 0px; FONT-STYLE: italic; = BACKGROUND-COLOR: #a81b0e } DIV.cited-ref LI.ovfl SPAN.flag { PADDING-RIGHT: 0.3em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; PADDING-BOTTOM: 0px; VERTICAL-ALIGN: middle; COLOR: = white; MARGIN-RIGHT: 0.5em; PADDING-TOP: 0px; FONT-STYLE: italic; = BACKGROUND-COLOR: #a81b0e } P.desc { DISPLAY: none } DIV.brieflink DIV.PPMCPubmedRA UL LI.item P.note { BACKGROUND-COLOR: #f8f8f8 } DIV.cited-ref { LEFT: -1000px; TEXT-ALIGN: right } DIV.cited-ref UL { PADDING-TOP: 0.55em; TEXT-ALIGN: left } DIV.cited-ref A.all-articles { MARGIN-TOP: 0.5em; DISPLAY: block; FONT-SIZE: 80%; COLOR: = rgb(35,35,35); TEXT-DECORATION: none } DIV.cited-ref A.all-articles:hover { TEXT-DECORATION: underline } DIV.port { MIN-WIDTH: 250px; MAX-WIDTH: 350px; MARGIN-LEFT: 0.75em; WIDTH: 350px } DIV.x-panel-body { BACKGROUND-COLOR: transparent } DIV.sameauthor-seemore { FONT-SIZE: 75%; TEXT-ALIGN: right } DIV.x-panel-body SPAN.separator-bar { MARGIN: 0px 0.5em; COLOR: #ccc } SPAN.review { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-SIZE: 85%; = PADDING-BOTTOM: 0.1em; COLOR: #fff; PADDING-TOP: 0.1em; FONT-STYLE: = italic; BACKGROUND-COLOR: #a81b0e } @media Print =20 { HTML BODY.pmc-body { MIN-WIDTH: 0px } TD.sidebar-cell DIV.port { DISPLAY: none } #ArticleRefDocsums { DISPLAY: none } .format-menu { DISPLAY: none } .other-sections { DISPLAY: none } TD.content-cell { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } DIV.section-content > DIV.p { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } DIV.sec { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } #Table3 TD.sidebar-cell { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } TD.content-cell { PADDING-LEFT: 0px } } .mb { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .mb UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .mb A { DISPLAY: block; WIDTH: 10em; CURSOR: pointer; TEXT-DECORATION: = underline; outline: none } .mb LI { FLOAT: left; WIDTH: 10em } .mb A.first-link { COLOR: #336699; TEXT-DECORATION: none } UL.mb LI SPAN.delta { COLOR: #336699 } .mb LI UL.submenu { LEFT: -999em; WIDTH: 10em; POSITION: absolute } .mb LI UL UL { MARGIN: -1em 0px 0px 10em } UL.mb LI.submenu-item UL { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; LEFT: -999em; = BORDER-LEFT: red 1px solid; BORDER-BOTTOM: red 1px solid; POSITION: = absolute } UL.mb LI.active-item UL { LEFT: 3px } UL.mb LI UL.opened { BORDER-RIGHT: #ffffff 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #ffffff 1px solid; MARGIN-TOP: 4px; PADDING-LEFT: 2px; LEFT: auto; = PADDING-BOTTOM: 2px; BORDER-LEFT: #ffffff 1px solid; PADDING-TOP: 2px; = BORDER-BOTTOM: #ffffff 1px solid; BACKGROUND-COLOR: #ffffff } UL.mb LI UL.opened LI { MARGIN-BOTTOM: 3px } UL.mb LI UL.opened LI.active-item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: #336699; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } UL.opened LI.active-item A { COLOR: #ffffff } UL.mb LI UL A { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: 0px = 3px; COLOR: #222222; PADDING-TOP: 2px; TEXT-DECORATION: none } ------=_NextPart_000_0000_01CA72A3.109DE760 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/js/jquery-1.3.2.min.js /*=0A= * jQuery JavaScript Library v1.3.2=0A= * http://jquery.com/=0A= *=0A= * Copyright (c) 2009 John Resig=0A= * Dual licensed under the MIT and GPL licenses.=0A= * http://docs.jquery.com/License=0A= *=0A= * Date: 2009-02-19 17:34:21 -0500 (Thu, 19 Feb 2009)=0A= * Revision: 6246=0A= */=0A= (function(){var = l=3Dthis,g,y=3Dl.jQuery,p=3Dl.$,o=3Dl.jQuery=3Dl.$=3Dfunction(E,F){return= new = o.fn.init(E,F)},D=3D/^[^<]*(<(.|\s)+>)[^>]*$|^#([\w-]+)$/,f=3D/^.[^:#\[\.= ,]*$/;o.fn=3Do.prototype=3D{init:function(E,H){E=3DE||document;if(E.nodeT= ype){this[0]=3DE;this.length=3D1;this.context=3DE;return this}if(typeof = E=3D=3D=3D"string"){var = G=3DD.exec(E);if(G&&(G[1]||!H)){if(G[1]){E=3Do.clean([G[1]],H)}else{var = I=3Ddocument.getElementById(G[3]);if(I&&I.id!=3DG[3]){return = o().find(E)}var F=3Do(I||[]);F.context=3Ddocument;F.selector=3DE;return = F}}else{return o(H).find(E)}}else{if(o.isFunction(E)){return = o(document).ready(E)}}if(E.selector&&E.context){this.selector=3DE.selecto= r;this.context=3DE.context}return = this.setArray(o.isArray(E)?E:o.makeArray(E))},selector:"",jquery:"1.3.2",= size:function(){return this.length},get:function(E){return = E=3D=3D=3Dg?Array.prototype.slice.call(this):this[E]},pushStack:function(= F,H,E){var = G=3Do(F);G.prevObject=3Dthis;G.context=3Dthis.context;if(H=3D=3D=3D"find"= ){G.selector=3Dthis.selector+(this.selector?" = ":"")+E}else{if(H){G.selector=3Dthis.selector+"."+H+"("+E+")"}}return = G},setArray:function(E){this.length=3D0;Array.prototype.push.apply(this,E= );return this},each:function(F,E){return = o.each(this,F,E)},index:function(E){return = o.inArray(E&&E.jquery?E[0]:E,this)},attr:function(F,H,G){var = E=3DF;if(typeof F=3D=3D=3D"string"){if(H=3D=3D=3Dg){return = this[0]&&o[G||"attr"](this[0],F)}else{E=3D{};E[F]=3DH}}return = this.each(function(I){for(F in = E){o.attr(G?this.style:this,F,o.prop(this,E[F],G,I,F))}})},css:function(E= ,F){if((E=3D=3D"width"||E=3D=3D"height")&&parseFloat(F)<0){F=3Dg}return = this.attr(E,F,"curCSS")},text:function(F){if(typeof = F!=3D=3D"object"&&F!=3Dnull){return = this.empty().append((this[0]&&this[0].ownerDocument||document).createText= Node(F))}var = E=3D"";o.each(F||this,function(){o.each(this.childNodes,function(){if(thi= s.nodeType!=3D8){E+=3Dthis.nodeType!=3D1?this.nodeValue:o.fn.text([this])= }})});return E},wrapAll:function(E){if(this[0]){var = F=3Do(E,this[0].ownerDocument).clone();if(this[0].parentNode){F.insertBef= ore(this[0])}F.map(function(){var = G=3Dthis;while(G.firstChild){G=3DG.firstChild}return = G}).append(this)}return this},wrapInner:function(E){return = this.each(function(){o(this).contents().wrapAll(E)})},wrap:function(E){re= turn this.each(function(){o(this).wrapAll(E)})},append:function(){return = this.domManip(arguments,true,function(E){if(this.nodeType=3D=3D1){this.ap= pendChild(E)}})},prepend:function(){return = this.domManip(arguments,true,function(E){if(this.nodeType=3D=3D1){this.in= sertBefore(E,this.firstChild)}})},before:function(){return = this.domManip(arguments,false,function(E){this.parentNode.insertBefore(E,= this)})},after:function(){return = this.domManip(arguments,false,function(E){this.parentNode.insertBefore(E,= this.nextSibling)})},end:function(){return = this.prevObject||o([])},push:[].push,sort:[].sort,splice:[].splice,find:f= unction(E){if(this.length=3D=3D=3D1){var = F=3Dthis.pushStack([],"find",E);F.length=3D0;o.find(E,this[0],F);return = F}else{return this.pushStack(o.unique(o.map(this,function(G){return = o.find(E,G)})),"find",E)}},clone:function(G){var = E=3Dthis.map(function(){if(!o.support.noCloneEvent&&!o.isXMLDoc(this)){va= r I=3Dthis.outerHTML;if(!I){var = J=3Dthis.ownerDocument.createElement("div");J.appendChild(this.cloneNode(= true));I=3DJ.innerHTML}return o.clean([I.replace(/ = jQuery\d+=3D"(?:\d+|null)"/g,"").replace(/^\s*/,"")])[0]}else{return = this.cloneNode(true)}});if(G=3D=3D=3Dtrue){var = H=3Dthis.find("*").andSelf(),F=3D0;E.find("*").andSelf().each(function(){= if(this.nodeName!=3D=3DH[F].nodeName){return}var = I=3Do.data(H[F],"events");for(var K in I){for(var J in = I[K]){o.event.add(this,K,I[K][J],I[K][J].data)}}F++})}return = E},filter:function(E){return = this.pushStack(o.isFunction(E)&&o.grep(this,function(G,F){return = E.call(G,F)})||o.multiFilter(E,o.grep(this,function(F){return = F.nodeType=3D=3D=3D1})),"filter",E)},closest:function(E){var = G=3Do.expr.match.POS.test(E)?o(E):null,F=3D0;return = this.map(function(){var = H=3Dthis;while(H&&H.ownerDocument){if(G?G.index(H)>-1:o(H).is(E)){o.data(= H,"closest",F);return = H}H=3DH.parentNode;F++}})},not:function(E){if(typeof = E=3D=3D=3D"string"){if(f.test(E)){return = this.pushStack(o.multiFilter(E,this,true),"not",E)}else{E=3Do.multiFilter= (E,this)}}var F=3DE.length&&E[E.length-1]!=3D=3Dg&&!E.nodeType;return = this.filter(function(){return = F?o.inArray(this,E)<0:this!=3DE})},add:function(E){return = this.pushStack(o.unique(o.merge(this.get(),typeof = E=3D=3D=3D"string"?o(E):o.makeArray(E))))},is:function(E){return = !!E&&o.multiFilter(E,this).length>0},hasClass:function(E){return = !!E&&this.is("."+E)},val:function(K){if(K=3D=3D=3Dg){var = E=3Dthis[0];if(E){if(o.nodeName(E,"option")){return(E.attributes.value||{= }).specified?E.value:E.text}if(o.nodeName(E,"select")){var = I=3DE.selectedIndex,L=3D[],M=3DE.options,H=3DE.type=3D=3D"select-one";if(= I<0){return null}for(var F=3DH?I:0,J=3DH?I+1:M.length;F=3D0= ||o.inArray(this.name,K)>=3D0)}else{if(o.nodeName(this,"select")){var = N=3Do.makeArray(K);o("option",this).each(function(){this.selected=3D(o.in= Array(this.value,N)>=3D0||o.inArray(this.text,N)>=3D0)});if(!N.length){th= is.selectedIndex=3D-1}}else{this.value=3DK}}})},html:function(E){return = E=3D=3D=3Dg?(this[0]?this[0].innerHTML.replace(/ = jQuery\d+=3D"(?:\d+|null)"/g,""):null):this.empty().append(E)},replaceWit= h:function(E){return this.after(E).remove()},eq:function(E){return = this.slice(E,+E+1)},slice:function(){return = this.pushStack(Array.prototype.slice.apply(this,arguments),"slice",Array.= prototype.slice.call(arguments).join(","))},map:function(E){return = this.pushStack(o.map(this,function(G,F){return = E.call(G,F,G)}))},andSelf:function(){return = this.add(this.prevObject)},domManip:function(J,M,L){if(this[0]){var = I=3D(this[0].ownerDocument||this[0]).createDocumentFragment(),F=3Do.clean= (J,(this[0].ownerDocument||this[0]),I),H=3DI.firstChild;if(H){for(var = G=3D0,E=3Dthis.length;G1||G>0?I.c= loneNode(true):I)}}if(F){o.each(F,z)}}return this;function K(N,O){return = M&&o.nodeName(N,"table")&&o.nodeName(O,"tr")?(N.getElementsByTagName("tbo= dy")[0]||N.appendChild(N.ownerDocument.createElement("tbody"))):N}}};o.fn= .init.prototype=3Do.fn;function = z(E,F){if(F.src){o.ajax({url:F.src,async:false,dataType:"script"})}else{o= .globalEval(F.text||F.textContent||F.innerHTML||"")}if(F.parentNode){F.pa= rentNode.removeChild(F)}}function e(){return +new = Date}o.extend=3Do.fn.extend=3Dfunction(){var = J=3Darguments[0]||{},H=3D1,I=3Darguments.length,E=3Dfalse,G;if(typeof = J=3D=3D=3D"boolean"){E=3DJ;J=3Darguments[1]||{};H=3D2}if(typeof = J!=3D=3D"object"&&!o.isFunction(J)){J=3D{}}if(I=3D=3DH){J=3Dthis;--H}for(= ;H-1}},swap:functi= on(H,G,I){var E=3D{};for(var F in = G){E[F]=3DH.style[F];H.style[F]=3DG[F]}I.call(H);for(var F in = G){H.style[F]=3DE[F]}},css:function(H,F,J,E){if(F=3D=3D"width"||F=3D=3D"h= eight"){var = L,G=3D{position:"absolute",visibility:"hidden",display:"block"},K=3DF=3D=3D= "width"?["Left","Right"]:["Top","Bottom"];function = I(){L=3DF=3D=3D"width"?H.offsetWidth:H.offsetHeight;if(E=3D=3D=3D"border"= ){return}o.each(K,function(){if(!E){L-=3DparseFloat(o.curCSS(H,"padding"+= this,true))||0}if(E=3D=3D=3D"margin"){L+=3DparseFloat(o.curCSS(H,"margin"= +this,true))||0}else{L-=3DparseFloat(o.curCSS(H,"border"+this+"Width",tru= e))||0}})}if(H.offsetWidth!=3D=3D0){I()}else{o.swap(H,G,I)}return = Math.max(0,Math.round(L))}return = o.curCSS(H,F,J)},curCSS:function(I,F,G){var = L,E=3DI.style;if(F=3D=3D"opacity"&&!o.support.opacity){L=3Do.attr(E,"opac= ity");return = L=3D=3D""?"1":L}if(F.match(/float/i)){F=3Dw}if(!G&&E&&E[F]){L=3DE[F]}else= {if(q.getComputedStyle){if(F.match(/float/i)){F=3D"float"}F=3DF.replace(/= ([A-Z])/g,"-$1").toLowerCase();var = M=3Dq.getComputedStyle(I,null);if(M){L=3DM.getPropertyValue(F)}if(F=3D=3D= "opacity"&&L=3D=3D""){L=3D"1"}}else{if(I.currentStyle){var = J=3DF.replace(/\-(\w)/g,function(N,O){return = O.toUpperCase()});L=3DI.currentStyle[F]||I.currentStyle[J];if(!/^\d+(px)?= $/i.test(L)&&/^\d/.test(L)){var = H=3DE.left,K=3DI.runtimeStyle.left;I.runtimeStyle.left=3DI.currentStyle.l= eft;E.left=3DL||0;L=3DE.pixelLeft+"px";E.left=3DH;I.runtimeStyle.left=3DK= }}}}return L},clean:function(F,K,I){K=3DK||document;if(typeof = K.createElement=3D=3D=3D"undefined"){K=3DK.ownerDocument||K[0]&&K[0].owne= rDocument||document}if(!I&&F.length=3D=3D=3D1&&typeof = F[0]=3D=3D=3D"string"){var = H=3D/^<(\w+)\s*\/?>$/.exec(F[0]);if(H){return[K.createElement(H[1])]}}var= = G=3D[],E=3D[],L=3DK.createElement("div");o.each(F,function(P,S){if(typeof= S=3D=3D=3D"number"){S+=3D""}if(!S){return}if(typeof = S=3D=3D=3D"string"){S=3DS.replace(/(<(\w+)[^>]*?)\/>/g,function(U,V,T){re= turn = T.match(/^(abbr|br|col|img|input|link|meta|param|hr|area|embed)$/i)?U:V+"= >"});var = O=3DS.replace(/^\s+/,"").substring(0,10).toLowerCase();var = Q=3D!O.indexOf("",""]||!O.indexOf(""= ,""]||O.match(/^<(thead|tbody|tfoot|colg|cap)/)&&[1,"",= "

"]||!O.indexOf("

Formats:

PubMed articles by these = authors

PubMed related articles

Recent Activity

Links

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information