From: Subject: Wiley InterScience :: Article :: HTML Full Text Date: Fri, 25 Sep 2009 16:06:44 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="multipart/alternative"; boundary="----=_NextPart_000_0000_01CA3DFA.2D78F2E0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: multipart/alternative; boundary="----=_NextPart_001_0001_01CA3DFA.2D78F2E0" ------=_NextPart_001_0001_01CA3DFA.2D78F2E0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/HTMLSTART Wiley = InterScience :: Article :: HTML Full Text ------=_NextPart_001_0001_01CA3DFA.2D78F2E0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/blank.html UNTITLED_PAGE= ------=_NextPart_001_0001_01CA3DFA.2D78F2E0-- ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/jpeg Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/logo.wiley.526x59.jpg /9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAARgAA/+4ADkFkb2JlAGTAAAAAAf/b AIQABAMDAwMDBAMDBAYEAwQGBwUEBAUHCAYGBwYGCAoICQkJCQgKCgwMDAwMCgwMDQ0MDBERERER FBQUFBQUFBQUFAEEBQUIBwgPCgoPFA4ODhQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQU FBQUFBQUFBQUFBQUFBQUFBQU/8AAEQgAOwIOAwERAAIRAQMRAf/EALMAAAICAwEBAQAAAAAAAAAA AAMEAgUBBgcACAkBAAMBAQEBAQEAAAAAAAAAAAABAgMEBQYHCBAAAQIEBAIGBQgIAwYHAQAAAQID ABEEBSExEgZBsVFxIjJCB2GBwcIT0VKC0kOTFBWRoSMzU1RVCLM0FvBicpKyRKJzoyRkNXUYEQAC AgEBBwEGBQUAAwAAAAAAARECAxIhMVGRUhMEBUFhgTKSFHHBQlMG8KGx0SKiMxX/2gAMAwEAAhED EQA/ANg81/NrcPmFeqmkt1W7RbOp1lqhoqda2xUoQuYfqO6VKWUhSUKEmxIAatSlfceF6fXDVN/P /j3L+tp8x5fk91tfp4GjU7NYc33cj41fLHp6Ty+3j6VyRaMUtUZTdcz+cro64UE9unSuQ81R1EhN xfDxGFBPbpwXIZTQvy76+PiMIWinBcgooHp95WfSeiAWinBcj34F6XeVw4mEGinBciJoHpd5XHie EAaKcFyIKoXpy1Kz6T0QBopwXICaF6XeVkOJgDRTguQJVC/j21ceJhh26cFyBqon599efzj0QBop wXICaKo+evh4jDDt04LkDVRVHBxeR8RgDRTpXIgaKpn+8Xn849HXALRTpXIh+Dqf4i+HiPywD7dO lciC6GoUMVryPiPywgVKcFyBrt1TPsuLzy1HohQVppwXIEaKrAxW5w8R+WFBWinBcg34SqkP2rmR 8SvliiO3TpXIA5SVWs/tHP8AmV0RLKVKRuXIEaWq/iucPEYRWinBciSaerKcHXMJ+JXyw9pDx4+l cgTtPWpMw85Kcu+ro64HI1jx9K5ACit4uucPGr5YnaPtY+lciKmawiYfdlj41fLD2i7ePpXJAFs1 s/37ufz1dHXBtDt4+lchZbVd/MO8PGr5YW0fbx9K5IVcbr8ZVD3Hxq+WDbxH28fSuSFnE3Cf+Zez /iK6OuDbxDt4+lckKOC4/wAy9w+0X8sT/wBcSu1i6VyQm6bkJ/8Aun+P2i/lg/64j7WLpryQm6q5 A/5t/P8AiL6OuFNuLH2sXTXkhRxy5/zb/D7VfywptxY+1i6a8kKrcun84/x+1X8sE24sOzh6K8kA W7dJ/wCcfz/ir6OuCbcWHZw9FeSAKeuv85UcPtV/LCm3Fh2cPRXkgSn7r/OVHH7VfD1wTbiw7OHo ryQMv3Sf+cqM/wCKvo64JvxYuzh6K8kCNRdP5x/h9qvj64NV+LDs4eivJA1VF0/najj9qvh64Wq/ Fh2cPRXkiC6q5jOtfGP8VfR1war8WPs4uivJEfxd1l/najIfar4+uFqvxfMOzh6K8kDcrrqhM/xt Rx+1X8sS7X4vmUsGF/oryQuqtuqj2q2oOPF1fR1xGq/F8zVYcPRXkiTdZdUpmK2oE5far+WGrX4v mTbDhf6K8kDer7qcDXVBzP71fyxNr34vmVXBh6K8kBNddR/3tRn/ABV9HXEa78XzNOxh6K8kQFfd pgitqeGTq/lha8nF8x9jD0V5Iy5cbwQR+YVMsftnPrQnkydT5hXx8HRX6ULquN2Sf8/U/fOfLGby ZOp8zVePhf6K8kDVeb2MrlVffufWjN5snU+bLXiYOiv0oAu8Xs53KqPW+59aIebL1PmzReJg6K/S j353ff6nV/fufWg72XqfNi+08f8Abr9KMG+X3+p1f37n1oO9l6nzZX2fj/t1+lGPzy+/1Or+/d+t C72XqfNh9n4/7dfpR788vv8AU6v79z60Hfy9T5sPs/H/AG6/Sj357ff6nV/fufWg7+XqfNh9n4/7 dfpRn89vn9Tq/v3PrQ+/k6nzYfZ+P+3X6UZ/Pb5/U6v79z60V38nU+bF9ng/br9KMi+3v+pVX37n 1offydT5sX2eDor9KJi+3v8AqVV9+59aK7+TqfMn7PB0V+lEhfL1/Uar79z60Us2TqfMn7PB0V+l ExfLz/Uan75z60Us1+p8yfs8HRX6UTF8vH9QqfvnPrRfev1PmS/Dw9FfpRP87u8v/sKn75z5Yfev xfMn7PD0V5I+vqS1zlh82PoWjzNQveLtS2Wqp7ZUNutOVyShisCNTaHFHSJjjI5iOa9o2FVTe0sK LaO562gQxdLoqlr2KgqaqKQyDjUhg4nsg+iM4cbWGpew2AbNdUK0t3OsbNYEFEnSoMKBmfh6pyB6 Ilk6vcWCLDdqd0raq01DClNhTT6ACltAk4UqTmpRkccIlsUos6agcdbSt5gsOK7zSiFFOHSMIWoU E1W0JTqI4Jg1BBY0G3qN6qpKGuL7dTXtqepktNqUnRPAlQQvPPKQGZjz8vlus6Y2Hfi8bVEztF2L FS19UlqncXRsirTQVDlckhLTzgkgqUkSko4ZYQ/u9Kl7dk7Bfay4WzbG0sUeXdQunu1S5X0rLdje cYufxCtJa+Cj4gUcO6sd3pjJ+pVlKHt3Gv8A8+0Nytgn/oZSmnlqr6dDzFr/ADt5hQc1opl4pB7O CiOEX/8AQrO574J+xtx9klVddvt2u22a6O1LTjN6bNQwlAVNCEnSdUxKYPRHRj8pXtZR8phk8Z0r Vz8xY3bYtBZXG6e4bktbVY4mnWaRS3A8luoI0rKdOXamfRHNT1HVuqzov4OnfZAXtg1NNcb5QVtS zTt2JgVFRVrC/guJdl8MNkCZK59npjVefV1q0vm9hm/CsrWTfy+011NsS4NSU4E+yPRVjz2Y/KhK engmCRSBFA2cCJd7PrgkZP8AKgTMJmJ+yCREfyn/AHeCecEgRNpwPZ6ecEhINdkClTlIz6PRBI5A GxrlgAcBzhD1EE2daFGaMCFc4JCTLln1AjTx9kOSZK1dqlgU44c4ReoF+XaZ9ns4zgBs85aUq4YE +yGRqK561ON8MJCRhF6hZVCCCFJ4HGGEgnLUDiBPH2Q4J1CTlqw7vAc4IHrEnrVgezwVzggNYm7a sT2ePsggesRctf8Au8E84UBrFHLXgcOCucGkNYuu1493j7INIdwWVbMuz83nBpDuAF23A9ngrnBp F3ASrd2suPsg0h3BdVvAGIkJJ5wtIaxN6mEiED52PriWi1Ygi2knWoccB6oFQHlPKoglMyMJJ5wa RaxNyjWsk6TkcJemM3U1V4IG3rJ7vHj1QaB91E/wUgABwEPSR3ADlAFEk+mIdDRZQKqRtJ6cevhC 0oruNgVMjAJHRENGisDcpTI4cDEug65BFdOZ5cfZGLodKuLqp/R0Rm6GquAWxLh0xm6GquQDOJEL SN2IKa9kLSUrEC3E6StRHRC0jkxohQOT2mCAk9phwEnpQAZihEgYYjIMUImDBJJnVhFCg+/hTU9H SO1lUoNUzDZdedOSW0AqUcJ5AR9RZwj5lbTXPLazLqayurae+NXuxqKi2wsKL7TxIIUpLg7JlxGc cKfvN7v3QzsVvshf1uEhDTUitRE8SJAD0mPm/Xf5Bg9LxO1/+r/pqt7/ANL3m/i+JbM9mxcTabXY 7Yw02t9n8Q84JpSo9kJBlM9OIyj8gv8Ayvz/ACXqd9GrdWmxJfj8z5n0mPwMNFun8TbWtsWOraSy 9QJbXpkHWU/DEzjIknHrj6LxfU/L2TktPHev/KZNLeHha+VFDfNirt86ijJdpwZuII7ScP1x9n4f rEtUzbH1eyfy/wAHj+T6c6LVTajVKmg/YKkMZJ5x9A7HkpE7ZXV1LdaF5lp6qcokNVVscDvwmmyy 0lmqaePzCE6tAzwjws9d/v3/AJHvePbd/b8zX7s+Ljabp+XN1VNQVSkllNQsqccrFPB51yfiSkJC UnolGuOrlTv/ACMsl1Djd+ZtlFfdnXdiga3CXE3Le9Km3bg0uBDbTlpSSh5Q4KdOkTjz7UvV7P07 viehS9LLb+rf8Cgsde/ebh5h3h9QbRWWeopqFtagmTbckNITOUzpTkI6b001ovec1L6rXfuJXTbd detjbPfpX6ZKbZbnjWJdqG0upK3NaRonqJIyEXizKl7T7WRlwu9KxGxFn5kWu5XylccZatBsjVDR r/HhbRuRdZQApuYJURMylKMvFaVvbM/A18pN19kR8SsvdTeLnsHaVBUvpWVqeTXqTpLriKQ6aUOk Y4JKpTjq8eiWaxzeRkbw1/r8ATdqDaUplkfdj3VY8Fog7bgGiZeFPOHqCCvNuHzeCucPUEHhQFKu zhj7IeoIJJplACaQcE84WoUDItwUjVpzCj+uDUKDyrckKkZCZwn1Qaggh+WggEDgnnBqCCCrYJHD grnBqFANVsxy4+yHqCBdVrBHd4J5wahQLuWlJB7AyVw9MPUAFdqAMgmQnw6oqRCjlqBEimYknD1w SITdtCJHsDJXD0w5CRZy1AGQTLtdHoipEJOWsEd3gnnDkUiL1rEj2eCucMUiTtrGru+L2QxSV71u QgDVIYJz64Y5K96laAMgT3sh6YA2i5oHFqwaknVmcOHVDE2AXbcMuCecBOoXctuBw4K5wQLUJu0r SFyOergJ8IYSxRdOwQJieCcx6Yke0gq2oKdQQMQo5Y5w4FrYNdCASSMAc/owQLUIqbbAwSck84k0 2gHGxIyRwVzhDRFFMpxRJTJIP65Q4E7QDepNDZVLGSZdc4TQ1aWV66UmeZwVzjNo3VgK6THLj7IW krWB/CYjD5vOJ0l6ybtJ2VYcFQ3UiuTaVrlJjlx9kYup1K4qul9HRGboarILrpvR0xm6GyuANPJW XH2ROkvWQVTno6ITqNXAqp88OmIdTRXBKZx/26IWkpWBlv2RGkvURKPbCgqTBRCgckdMv1QoHJgi CBngIYpMygA8IYEp4QCP0qFsYepHWaloOUzjWh5oiYUhQIUJekYR9Jdny6Rz/wAornsBy919t27T 1VDcqwKKGqxYWlbbRJ0ollIYyVjHnZctcdHZ7kpOt1s4R9A/A/ZPU7CJlt1oaAMcEFM/WY/lz1fz snqPkZcj2t3rC4VhpH2ODEsVFVFrRrbQwgMhLtTTgpeVmEpJJmkcZEyJjTxbVrRKv/VqbH+Hu/Nm xslDVpW2H3lydHZSpRmFEcT1R9b4udWWqz2/5EOO1obb+IVglQ0FIM545/ojuv5Omsz7gNJuVA2m qdSgdgkS/TH3no/mvPg2uXRw/wAv7HzPmYVTJs3M1K6sUluck5c27ep8KIQ4+lnXI9CiJx61qK3s MKXddw9T2UrIcqVqfUcAtR1YaeHoh1qq7ibWdhV7Z9uecDymhq7JnL0xUIWpmKjadI6jRokJK/UY GkJWaKg7MtDlaujQ+2axsBxymCwXEoUMFFE5gHphaEVrYel2NS0ytaeITP8ATDVUhO7ZYU+22Kdw upGMlc4tbDNuSy/ByVgOMv8AwxeoiBeppAGZSz0D9cUrC0mjeYG8LXsCy/mle2p+oeUpmipEEJU6 7niTkkDFRi05BVk5q35u7+apG7/XbLV/pxyTn4lr4oPwz4gsgiUuJSBF7C9COz2pxF2tlJckMO06 Kppt5LFQnQ6gLxkpPAxEmbqXLNICynDgvnEOwoKzc7n5NZq27hg1H4Fpx/4KTIr+G2VaQZHOXRFK w1U03y63mrflDW1n5au2GjdbZ0LWV69Q1TB0pim4HakG6FhwA9o5Kzx4wtREEkNEuALxBVKcvRBI tIQ0IkMOCecGoWkr32VNlSVNjAKx9E4pMWkXWntYt+Lp9EVItIqtAkP2fBPH0w5FpImkQ4gqSOCp j1w5JgUqaBxOLSQZKxBz7sUrEwU7rTpGQBknh6fTFJhBWOp+IpxCHQpaNWtKSJpmeIGUVIQQFK+p Ui3rGrPLwxUkNAnbcCkakzwRhL0w0yBBy1NJBKUAGS+cVIpAO28au74vdipIK6ppg0kdgqMkZDDP pgke8pqlpxwKBwTJfZGHGApJITXRdqQHi92AJMtWiQC3U4yQQn18YaRna5J2jASokSAC+cMzkqap v4iylI/Z6v04QM1qoQgaTAYcE84mCpBKo5zAGernBAahtNAGwEgY6sevTFQYO0lfWU4JSgDIJJ6y YlmtGIrpcDhwVziYNVYEqlxy4+yCA1AU0k1pEvm84SQ3cK9SdhRl4Vw2jOttpVLpccuPsjJ1OpXF V0mGXARGk0VxZykwOHAxLqaq4sulM8Bx9kQ6mqyEVUnZBlmBC0h3BdylPR0xLqaLILrp5HLj7Ih1 NVcWWx7IzdTVXAqZ9sS6misDLePr9kS0WrAyj2RMFyRKfbEwOTGmCByYlBASelAM9KAD9TqWmwT1 I5x7d7HzaRqO76bavlzTP7+p7A3UXcOfDCmv2fbdVIqUQCEzGZCZx5fm4H5GG+JW066us8JUSdWN xZPfBZ+W/m9Z99O17aKNy33cICnqJTgdSaZRktbbgCZqBKc0iU+Mfgvrn8eyejN5Z7mPI9MrY67J eyXt2f8ALn2PcfT+P5azOIhm+sM1FPUtGnXNC8W3093SM59EhmI+SxY748i0PY91vZH9b0dpai50 zygO00hA0oKACkjp0kiRPXHt18/HZ9KXD/XvEMLq6dFO2VuFc1qUlAEpgADEk4Yx2W8qiom3O1iF gV1INSvxqw9R4eiPvP4je18eS73OyPH8/a0fLP8AdcgJ3BtXDNl//GTH6Pg3M8po6P5reYm5tiWa jb21YnK11yjFU/dnUFVHSttpSg6tMpqmoYKIz4xnSqs9rBo5nY91+e1x2bUeZ1De6attVE47+KtD rDQIZpz21AJQmYTnguco1aonpFB2bYu/anzF2I7f7DSsNbhbDtO5RVC1CnRVpkRNSQVaCFBWU+EY 2Wlwwg4H5NL8wb75nXitobmwa9LqVbgeqRr+NTIqAlaGppMspJykI3yQqhB1Pza82Ltt290Ww9kU iK3d1eGtTixrSyXj2EhOAKyO1NRkkYmM6VlS9woNQvW6PPLyqFFf95VNJfLDVuBmqYbDc2lqmSjU 222UqIB0ntJi0q22IIOpb736qxeXbPmBYUJqGHF0VQhp0SDlPUqQFIMsjpVKfAxlVTaBQcme3t56 70YO79n25FLtZLvw6GgCWXXHkoVoKla+0uR7xTpHRlGyVVse8IRtPnD5ebk3vsy2Oshpzc1q1P1F GxMNPKcSA6lorOYImmecKt0mJbDRtj+e723W6bam/wC2OsihSmlVWJQUvIS2nQkPMqAJkBIlP6It 0nagdTuly3TYrbtR7eIqE1Nkap01LbzB1fESTJKU+kqOnHjnGS3wTBx/b9/88vNFupvW06iksNgZ WtFMhwIPxFCRKdS23FKI4qkkRdtNd5UI6Za6rzCpthX2s3vT0tNuC3NVK6R6mKVodSwwVpdUkEpx Iy/UIzlTsFBq3kbvG+bzsl2r9xPturo6htttaG0MhLejUZ6ABGl1ArVNWd8w9/8AmTuKtsvlmGbf Z6An4t0fCVFSNRAWStKgAuXZSEzlxioSW0elIsNo7/3hY97teXvmOlp6rqiPwVzaCU6lLSSiegBK krlpB0gg5wmlEoTqo2BfNzzW3ftR5y2WG0qpqZkModvlUjW2tbqVKSGR3eBxVPEHCCtUwVUa5V7k 839qbdtW/brcKa+7duKG1u0ym0NraD+KQShCCJ5TExPhFKG4HpTOjXPf1motit77CFLo320Lp6Yk BxTzg0hufSFTBPonC9sGWjbBzWz1nnVvik/1HaKmltlsWT+DpVpQA6EKIw1IWoiYlqJE4uUi2qo6 DRXa+2LZ7+4N807dJW0SHVVCaY6kqSFBKOJGpZOABhSZOqb2HPbZfPN/zGS/ettOU1msza1IpkL0 ftFpGKdS0LKj0mQTFTBTrWu8tdibuuO7VXXa1+aTR7st6FIS+2NKVFCi2SUiclIUROWcOSL0S2rc WNg2xW0Ny+M/SKbSS6talESaTpUnQFalFzUSkzwy6YckWco2x2kGrLxe7FpnO0Vr7DTaQVkDBGHH OKTJgqapxICg2meC+0rripDSIqW4FdtAUNXV4YuSXUCVsKACgUmSM8ePohyQ6i7lHTPBRCUrMlzl nnDJ2oXNsZbcKkokdXHHwwyW2AXSCQw4I5w0ySsraCocCkpA+HJchPE48YBppFc7bH0rxbPe4SPh hlakJqoHABNs5I4HphBJligJKnFpwSFy65wyLWDPMBsKWRgFfr0wzNbSjXT6u0cyEk/piTeQK6bA 4cFc4QSCVSkqy8Xuwwkg1RkuIOkykkzlCSFa2wm/SEtrCRMkLAHrimiK22leq2Ok4gDH3YnSa9xC 6rXgNR4JyHpidJXdArtqADMEmSs+uE6lLKwC6IA4Jlj7INI1kFHKTDLgOcRpNVkE3aTA4cDziHU2 WQUcpZHLj7Ih1Na5BNynkMuiM3U3VxRxjPDpiHU3rcXWzj6/ZGbRqrAFN+yIg0Vgake2JaLTIlGc KCpIlMKByY0wQOTGmFASfq7StjSnqRzj07s8JIaqrZQ3Sift9wYRU0VQhxDzLg1JUkniI5bM2SNF rdq7W8rrVer9tWzL/ME06VDW848JJM1CSyZJxmZYx+Peofdef6nT03zckYrWmtlVKdj+Db3Lgz15 phwPNjU2Sjb7Jan4e0o/LjzxO4LorbtzoW6aoruzTupmWllIJLakEnSTLBQPojX13+I19N8a+Xxb WvVfPXJE6fbEf1A/E9QveyrkS2+2u4662mmfcShCHGnFkAJTJYmeicjH5nRY8jSSab+J7Y2RTOOo ZYDlR8IaEJEkJJnMqJxwJjvSpe6pRO8bEt0+/wCJLLFLak4KIJ7PdwSJHIeiP3D0bwX4njqlvme1 xu/BfgeB5GTXefYfKv8AdoANw7T/APJqP8ZEfT+PuZyWOv8AnIkDyYvx/wDgs/8AU1GGP50NrYc7 8qQP/wCatynop7tP7oxrk/8AYhLcN/2lpCtl3z/9FX+A1C8jegqax/bepNN5qbwoKg/DqlIqAlpW CiWqrtD1Ti83yoSKjz521+RebNJui+oqv9J3f8Op2roToeb+E2llxCVykFgJ1gcRFYrTWFvBhbpb f7d00jRd3debil9SQmlaW46sFRwKkraAEszMz6ISeTgLYdH85bHbtt+QblltTrj1tozQopXXjqWp svIUkkyHT0Rnjc3G0bL5BNpX5R7c1AEaH88f+8eicr/6YJFv5ib4sXlzaGbveKWoqGah78OhFIjU RqM1KUSQkADpOOQhUTs4FBxXzg8wfJjeezqh2keVV7nkn8r007jdS05hg4taQNA8Q1H0RvSt0xQT 2jsHct5/tyuFtDazcKxxdfaaNQktTCHELCQD88oWpPTMdMK10rhBLyL81tm7Y2irbO6a02i5291+ aX2l6XEuL1YFIMlAkgpIEPLRtygg6m9vfbW/dg7suG2qhVTS0dNW0zq1oU0daaVSgQFSOkg4GMdL rZSEHK/7ZLYq67M3TRpWEfHqEsauI+Ixpn+uNsrhoUHLNp7f23t/dF22t5m11dYX2DoYqqVa22VL bJHb0pJKVjFCpSjVttShnSto7U8mLzvu30O39wXS53ylP4ymfWVKpyaY69GtaAZ8ej0zjN2sltQi 8/ugpQxsi2qCpk17Y/8ASchYnLElBX7+SB/bXZVdNPbv+tMOvzh7Srq9p1+5f7crOq1NKeraBZrS wgFS3G2lupWEgZkBWqXoitUWF7S48rvN7YtBsm32m+1qbZc7U0mmeacbWfiBtRktBSkzmMxnOC1X JLqbBu12j82PK66ubPcVU/E1FhCkltanKR5LhQUqxBUB2esQlse0lKGcJ2FTeXT9sco94Xm42S80 rqw4ylxbbCkHLSEoVJQOCgY1cmlp9h0nyvs3lsb3XXraVwrquto0hh9VXPQ4HyCVpmkEiaeMG0yv MbTq620rQVJxTJzH1wHPBX1tG8tRLS5dru5eHpi0yYNefplJMlpkqSM+uLTFAi9TiSsOC+cVJMCj lP28vF7sXJLQJu2LeAURpRJGPTjwgklhjQttIKUJlg5M8TjDkyYrVIbZJK89WCRmexFSTBSreezA GkhEky9MMekAt9QB1Ng4Lyw4wydJBT7ZXigjtYyx8MMjQCSWndKUg6iEcPTAJ1gw5T4HqXzhkCzi GgspUoAhWR/4YYQKqbYkO0nJHEdMIIYu4hmR7Scl8R0wwhglhkK7w73uwChi4bQ53TOQRP8ATADU AnKbA4cF84CZArpu1l4vdhhIqqmwGHBPOEORZymwOHBXOENWF3KXtHDxe7BBSsJuUuGI4J5xMGiu JPUsgcOCucS0a1uJPUuJw4+yJaNVcQdpsMuA5xm0dCuIPMYH184zdTorcTcZkThx9kZupvWwotr2 Rm0bqwBSPbENGiZEozhQVIMohQVJgpiYKkxpggcn6u0wwT1I5x2WPHqWLeCT1L5xzWNkHXTsVH7O oQHEFUlJPEacQfQY8T1P0rB59FXKttXKa2NP3M6cWV43sNVovLrbtrvAv1utVMi46i4hwJklCnJg lKD2QZEiYj4r1LwvX8mN4O8s2J8dKb/GVt+o6cFfFpfWq6bfGPgt39jbEMqZQfh07JeWFBxztBKU 5EJGqc/THz2H+L+ctnbom971bEvdDb+Ow9N+ZjXtGadotSSZAAy0oGlOU+s+uPufSP49j8OLXatf 3KKr/f4s8/N5TvsWxBgcB1I5x9WcRS3zaW19yuMv3+0UtyepkuCnXVNJdUgFQJ0lQMsYpWa3AWFw tdtutC7ablStVVsek27SPJC2lICQQCk4SwhJwAnQ7Z27brO7YaC2U1NZahJS/QNNpSwsPYLCkASO oZw5bcgZsu3LBtqmdpNv22ntlM6pbjrVK2lpKl4J1EJAmZACBtveBKg25YbZdK68W+3sU90ubgXX 1baAHXVJRIalf7Y4wNt7BB7jbLbeKJdBdaVqtoXUoDlPUIS42rHilQIgTgDXLX5X+Xljq/zC17co aetTrUh4MhSkmfh1T0+qKd7P2ig2C7Wa036jXbL1Rs19vdWkuU1QgONqKBqSSk4YETiU2twHrXar bZaBm22mlaorewE/BpmEhttGpZUZJGAmSTA3IBqukpq2ndpaxlFRTOpWlxl1IWhQJyKVTBgA1On8 pfLWkrxcKfa9vRVJWFJV8FJSCBOYQZpGPoi9duIoNvSlKUpSkAJAQABgAAYgDVr55bbD3FVm4Xrb 9FV1x1FVQtoBxRBw1KTIq9cWr2W5hBcUe3bFbrcuzUFupqa0uBTTlGy0lDSkLRJQKQADMHGJlgCs e2dv7aYcp9v22ntrDxbcebpW0tJUsYAkJlMyhuze8BbcWzdqbpQkbitNLcS0F/DW+2lS04+FeCh+ mGrNbhGbFtPa21kqa2/a6S2pUrtmnbShSuzxVmfWYbbe8Rm9WPb24aVujv1FT3GlbKHEM1KEupC8 RMAzxkYE2twC9ZYts1loRYKq3071laTpaoFtBTCQ2RokkiQ08IpTvEOW+1W6z0jVutVM3R0DBIZp 2UhDaARMgAYDEwSS0ahe/LjY1xqxcq7blC/VK0KW8WgCpROJWEyCp+mNK2YmP09OxbqVNHbmGqOk bSsNsU6EtISJ8AkCLIZrd62LtK+1hrbvZ6aqrCrtPrQAtUk+IiRPri0xS0MUVot1ppU0lspGqOmS ESaYQG0zn0ACKkh7SSviNalIMsF9WcMkKmobWuTg0K158O7FENAXqZt1ACkhQ0ty/TDTJaKertRk otGYk52T1xckg02tttc3O2vXlwHYipIZBbA0jDwt84aZDRU1ryG0qQ32lycE+AxihaSmebWt0qXi orx/5IoIElMdkYcG+cMQs6zgcOC+cMmAC2O3l4vdhiGqai+E2FKHbUGz1CeUBlYHVgMtKV4iHAke mcBKUlKtklZJxJXifowyxcs4DqRzhAAcZwOHBfOGIEpjtZeL3YYglLTgNlUs9A/QYEZ33knGMDhw XzhmYFbHa+l7sMQqpjAYcEc4AAOMCR6l84AkAtjtZeL3YBSKLpxLLgnnCLkTepsDhwVzhNFKwk9T do4cfZCaNVYrXqfDLgnnGcHRWxW1DEp9SozaOitiveZx9fsiGjprYQcb9kZtHSrC62/bENGqYIox MTBckFIiYKTIaIUFSY0QoHJ+rFP3U9TfON7HmofbyPU5zjCxqhtPe+l7sYstBUd0dSOcQUT4HqXz iRk/F9L3YQzwyHUjnAM8cj1L5whGfF9L3YYzAyHUjnAB45HqXzgEZ8X0vdgAiMh1I5wAeOR6l84A M+L6XuwCMDIdSOcAHjkepfOADPi+l7sAERkOpHOADxyPUvnABLxfS92GITq/3SfoczFITEFZHPJf OLEYPe+l7sAgfAdSOcMCCsj1L5wxFgz3E597xZ92JAC9+5Pd7qO9lnFITKNzJXUvnGpABff+n7sU iWKKyHUjnFIQo7krLJznFECznf8Ap+7FoklST0jvykic5aM/0wEsk93VZd1znDJF3O+cu/7kWZlV Wz+D4paW56JSz48YpCKB3JWWTnOKAXX3+Hf9yKIYmrIZZN84BMVcyVlk5zhiMNS/Eo7n7zxTl3YZ D3Dishlk3zgM2VNy7w/4XJTy73CGOpXr7/Dve7AAue6OpHOEDAOZHLJfOGIEqWvh3vT82GSMMS+A ju5J6fnQ0ZW3kXMjlkvnDIAr73Dve7DELKyGWSOcIGAcyOWS+cMQBfe4d73YCRVcpDLJHT0wihV3 I5ZK5wFIRe7xy73uwi0Vr+XDJPOJNqlXUccvFzjNnVUrXszln7IhnTUr3fkjNnTUVXlw4xDNkBVx iS0QMSUQMIoxCGf/2Q== ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/dot.069.gif R0lGODlhAQABAIAAAABmmQAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/auxnav.gif R0lGODlhwQBXAOYAAE2UtjmGrM/l/HuvzRRxnZfA3LXU7mGYtv+ZAGudv4+30VKQtYyyztTm+LjT 6FiRs12avSZul9Tm91SJrcHZ7bfR50WDqsje8Zq+2E2LsM7j9XOgvzl5oVCIrix1nzNxmkR9o2eb u67K4YOuy6/N487i9HalxD2BqDh6oWOUtsDX7KPD25G51NTn+KXG3bnU6YCpx8fd8FyWuFGWt1aZ uUOOsWajwFqcu0mRtD6KrzSDqmCfvi9+pih5oRpplRRhjSFxmw1WhAlOfQAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAADBAFcAAAf/gASCg4SFhoeIiYqLjI2Oj5CRkpODQkJBQZaam5ydnp+goaKjpKWm p6ipqpuZmZauq7Gys7S1tquusLe7vL2+v6Ctl7mausDHyMnKr5evrcTGnNGd08HL19ilusKYzN7N rN/hp8ShsNXS2eK05ejFps/d8sLgzdDv3PX03vL86fn23n07V6+gQYHlhlEjZQxgwHUHIWKaOIzi PIXFGuID16+iuGj39AkMmI/gxnvT9vljlsvhSnop/+krObFmTYU3LcbzaJMlyXhAeeJsubOkvW44 WVpUerFfSJgPmzJ1yhHjzoo2s2rdOi+nVaBNdTrDyo0i1qE8qfYs6rRr2KxH/+Ou9fkWLMmHP7gG yau3b1eyYP3CLSu4sLPChgPrVJyz7dCtR/diystXMuLLfStXrqkZs9bNnkNv7Sx6ImjBlCerloyA c5AJGzAx+IAJhAgRIDBNYJA7CAwGuhkIj7269GfXpFOfNo7a8+bUq5Wj/kGdMl++CFpbZ+Agb4MJ QSJoEF4iQhAGElYEQdFAQl4GMRgoiE1d8nXV0i3nx6/fsmn+9mlW33WkmQZddPndd6B9/YGmIH4F VifhhNlptxcDFewlwQNBpKDBXiWk8IMCElwQxAbtYaJABdBVh+B/L/I3YID9/ddZiw8yuFeLNupX n489zmhdjQAySGCAE1JYYf91DFygAAPfjchiEA4w8AMDFDTwgQsqNLCXAhRM8MAHQg5pnZnK/Sjh jgOiuaaLbZq5o5FzppkmjWUSGCeabMLZJptIJinhktUp4KQCDXCogAN7OaBAECtSYMIFGHg5ogYO VGCCoEn2KaingJ5Z55ujejrhqHbuaSqnoMIZ6plloronp9Rl1+ai1CU6Ync/OLorBg40EIJ7u8JK 65vH9qnsp8Ye6yyrpz4brZ+z5intjj784EO21XGLQJK4/qDrAw1EEIGui4bQAAXkUheutPDGK++8 9NZr77zcZpuvvhMumm2i2VJAAgkUZLvouRg80AJ1LGjwggMYULettt1SbDH/txTnW/GEGHd8ccZJ eiwxx4JqjLG2/I6s8cgkswwyyCezrO/E2+47M78+oJABdQ94kG0EI4zg8w8n7JxBBB48oO0JD8jw wM4Spxz1zCjLvHHVIousssUwc00zzi5LSLPVH5tcc8Ydeyx1yl/X7LbNWLuN9tltU2132XJ3ffPE UaPtNcx0720yymPX7Xfhb8d9c9Vb57343odnS8DbcttdeeCUC044znQTrnjnl2PeNuCiJ/644INX Prfno3POOeuhs0745EBkbnvmpM9tuu6lb2447rfXTbnvtvMePOrDAx888cf7UPvzzk++7eTS11z7 ttdj7/zb2d/e/fHXh2/7//fNk7+9+ds3Xz7l0KvvfubZQ99++u0DUfsBB2yLv/0H7KB//kDYnw/w 5zwBEjCAADwgAQd4gPs1kIH/+x//HmhACibQghGEIAIdyEEGOjCDFYwgAkVoPeehj37x014K5Rc+ 8dXvfOk7nwtj+EL6wRB78kNhDnEIwxa+8HlAjKEJS0hDHrIQhy284fxyuMMgspCJTrSfFKNoPxNW UYZS7OEThyhDKw4RilrkohNteMUq1hCIZhSjCrNYxjF2MYna66EQf/jFI6KRjWbMIxXTyMcpYvGN cGQjINP4RRXW0Yo+9GMb5chHI45xilmM4xYVScknNhKSmMykHjdZSU1mEv+Rn/TkHSkJyj52spSI LGUn7ShKUWLRlZB8JRB6MEsp0lKKCMikDgQgAPsNgJcGGID9alAAARTAAkBIQC+BIIAEAKGYvBTA AqT4S/s105cCMAAyW8nNbnrzm+AMpzi/eUv70TI75qylDXgJACCscwHrhMAzg1kAAwDhl7QUgDAT sE4DJACZtKxmD/QJhAU00wD2FOUty1nLcdrSoVNkaDohudBaSrSVF+VmDza60YaWswcVouUtC1DP BPRAmUCYgQDk2cwerNOdAsinMGUqUvutM5/OhIAAOmCBmlr0pw396UeB+tCKDnWiHLWoT4O61IU2 FagdralPK/pQTD5VqBz/BWlIZ9kDehqgB7/kZQFmqU+w9rKazByASAlqS4ESlAcGKKtQudpUqnK1 qHS1pVTnylCjKnWuRJVqVCnq0b0K9q6IFWlWF6vUrW40AALYAUp/OYNf1mCgJsWnMjcqABvUsqVZ RWtLZ/lLtQ7WqYrN61T/ytis3lWxsM3ra82Z1Nq+dqqpPa1f6Qpbw952scDNzmJ1Gk0c4HOgNhio Wqt53M5ylKCKvSlye2CBzMa0tlEFLnZ/i13tuja7vM3tdwXb3daCd7zeRW9505tVBAB3AMH8pQ0o +0scdNUANkBoDzpgzGLal7Om5SgO+isA+yozAfVkr4IXzOAGr9fBENZu/3ghzAPgVvjCizVAASqs 4bCWtQc4KGYBOrBR+AYzqx+ucIkRGuBfGmAGKnZwjDk648XWeMY1pnGEN5pjHdu4ByrGcHp77F0e GBnIPBaykHnM5BgHGclGxvCFn+xjKFs4q0fGspWpvGUdL7nJYFZylZ/sZC+PGclgRrOUraxlJts4 ylEG8pSPDGc5Q5nOeFZynOls5zXDOctSnnOSB11nP2+50Hc+tJynnOQ193nRf270nucc6EgLOs+Q /jOl+WxpTXM605e+dJ893WlQk7rTnNb0qEV96lYnOs+FJjWk74zoVtva0zq4ta53zete+xrOuSZ1 sH9N7GIL28jD5kGyh/9tAxsYudnPdjYPbJAAZSdgAMqmtpEHkIBcc9vI17Y2tnkQ7mlLewDnlra2 yY1tHTTb2+2GNg+4nWt5h1sH/AT3uOUtb3Q/e9/q3jfAo71tZ+O73VHOdbL/vHBb60DhClf2w4f9 cIkr++LIZjjGK27xi0c84hr3eMZFDvKSA3vjHv84yVPecZBj/OUs3zjFNe7yYHPc5SePuc1JXvKK Q1zmEp/4yh/OgZp3POUml/nMIT7xjzM94TxvObB9vnKJF13oPv+5zYs+dJbbXOVa1zrSsR70ppvd 7BY/O9PBPna0u/3pao872Zve9qzbHdl0n7vayy53p6/d7nFPe97jHoD/iRe+74hPvOIXz/jGO17x h+975HUweblX/vFqr3zhL//wyUd+852nfOhFP3rSi57zoD+86ju/+c+TXvNnT73hmx6A1Z+e8KWn /et1P3vOxz73owc97YWfegSEvvA0EDENCg9ffRY+m7XX5w6iacwADFgAlA+AiQegg+lHswCg/+XD nb+DuL649bdHP/pfX/vs9571u5f97eEvf+Kvv/XCT//xbX//7Nf+/wBYe9nxf5THYggVADRAYMvH SwMAWQMAAM03ANwXVjuAgAoIgXElga33S9HHfcZUfgbgf6nXfgFIgCaIfyhYgiq4gisogifIgvRH ginofgGYfTkQADeI/4O1l4MBUCE6CFngNwBBKAAdCFnQV305wIG1R1LBpH1EGAAGUIFOqIM5qITO V30zUAM8+H9buIM/WII32IVeOIYsWIYq2IViGIY7KIZcGIBs+IVq+IM5cIMVggA66Hw7yIE5cIUZ qE83qIRQKIQGEADFVIK/FIeESIR7OIT4FYeImIOO2IaS+IhjqIZhCIlyCIeZGImY2IZzSIWXmIlU SIZeGIqQmAMVModz6IefeIgOuIjQBH45UEw3CACdVU9JKACqiIO5uItzqIesuAAitoZyaIqlCIqj 6Im8uIyWyIu+eIy++Iyq2IyWeIqa+InYWI3TuI3cmB3b6IeHeIh7OP8A47hOrCiO5shLNyCO56iL 28iOA2BcMzCL7siN9niP+JiP+riP/HiPztiPAHmPCMCNBmgAOXADxhRXOzCO9EiO9DiH9SSExoSQ JCUANwCR9aiKFFlMELCH+IVQARmSIjmSJFmS26iFOYCS06iS03gD5ncDWmhiBbCKM1laKXmINaBh c6iT25eSuciSN5mBc+iS2bSQJ+mTKcmSWgiUR7mUSumTTKmKUYmU9jiVU3mUUsmNKrmUc4iSXOmV UNmVYfmUXfmUWwmUZlmWY5mUahmWbkmVVPmVXxmXYLmVSAmWYumVdgmXUsmVKymWbumXc9mXTpmU NXCYiGmYTnmYign/lYj5mJCpmIkZmZA5l5T5mJJZmY7ZmIbJlpNZmXL5mYWpmYxZmonpmZeZmaWZ mawJmq4pmqopmq/5mrE5m6BZm4tpm7q5m7xJmqOpmo7Zm4+JAzVAnIdpnMNZAxJ4mMupnANQnM0Z nfHonND5nNR5ndLJnNaZndi5nd6pncTJnRIYnt5Jntp5nt2JnuL5ncJZnO6JnK9JnPL5nu+JA/ZZ n8g5n/e5n8fZn8apn/9pn/w5n8UpoAVaoANKoANKn/upnwwqnwpKoO6JnxOqoBV6oRD6oBnqn/7p oAkqoAa6oAAaogmKnyDaoCSKoAF6nwcKoS5aoSKKoC1KoiGqoSd6/6ImOqIymqIl6qEPCqMZeqNC OqREWqRGeqRImqRKuqRM2qRO6qQAYJ9RigNROqUgaqVJOqVWugBSKqBV2qUAYKVfSqUnyqVaaqRY eqJpSqZq2qVkiqVVOqZwCqZsSqRhWqdX2qZfOqd02qcLEKd4+qZryqZyyqVsyqWGGqV/KqALsKhC OqZ4qqhXmqaQmqeMuqdemqmCmqdh6qiYigN/aqaP2qaG+qamKqZumqlxGqasyqpU2qqueqewKquw eqqzuqq3mqu6Wqu72qu4uqe9+qqxuqvC6qu5WqyziqzA6qsIMKu/FKb6ZIvRBK0FwKphhV/Gmq3a uq3c2q3e+q3fOv8DMwAA4jqu5goA2UGu4woAxUSuxmSLJFWt8BqmM1BMEkmu+Hqu9Mqq69qv+1qu 65qvAvuv+Squ6lqw/qqv6mqwDNuvAYuvBQux5lquB3uuBhuxB0uvExuxFquxC0uxACuuFTKxlKVS BWCyAKtPBltM9SoAIYuwIRuzMfuxDTuxFguyMruxOZuzNMuzNYuzHfuyMzu0Oxu0RVuudViu0CRW KsW0KCuu9sqyRzu1VFu1Vnu1WJu1Wlu1NEADM+C1Xvu14uq1Iyu2ImavCRhfX2tMZgtMNiC2cAu3 YSu2XVu0YAu2Y5u3ehu2fFuueHu3dAuweKu3fpu3g1u4gfu3hVv/t3fbtYA7t187uH8LuYz7uGCb HYFLWQlYAJvruCYLtsXEuJErupUbuYlbunTbuJXbt6X7uKMbuImburJbt6Y7u41ruq5LurCrurh7 u46rur8bvAgQvMknAF1rTJtbAOiWvANQvMT7vNAbvdI7vdRbvdZ7vdibvdd7A8HLvdzruN/7u6GL kAOAkNFkA+abTc4bvjTwve7bvvALv+8Lvr/rvfYbv+wbv887v/orv/XbvwBMv977v/07v/nrv/jb vQKcwDfQwAZsvw0svxE8wQhMwRbctRFcwe3rwBAswfebwR+8wSEcwiK8wSbMwR08wQ4swhzsvyn8 whiMvxe8wjTs/74DjMInjMPcCwE5XMMjrMMqDMFCnMI9HMQoHME8DAE63MM53LVK7MFFPMRBDMU8 fAM8XMIQrMQW3MIqzMJcfMRgHMZiPMZkXMZmfMZonMZqvMZszMY7cANvHMdw3MBvLMZ1fMd0PMd5 LMdxLMdwXMcOjMdzDMh6HMiFzMGAnMiGbMh9rMd8jMKPvMeDPMmDLMiEHMh+7Mia3MiT/Mh9vAON DMqeHMp//Ml4/Ml0fMei/MelDMqsPMqr7MqynMqt/MqoPMuinMu6XMq0zMe3XMim7MmV3Mmx7Mix rMvFjMyhvMyVrMy7fMy5PMzOHM3BDM3W3MrT7MvT3My2TM3YnP/N2/zMzszN4FzO5nzO6JzO6rzO 7NzO7uzONgDK8bwD8TzPylzPomzPyDzP+pzL+CzP9BzQAp3PAz3N+tzPAY3P/EzQ/0zQAO3M/2zP Cg3QC/3QCe3PFM3Q9IzQEX3RC13PzdZsG83PEx3SH+3RID3SGy3PCi3SLi3QJS3SFC3TMZ3QHV3R LZ3RH33SKM3SKv3SE+3RMG3T/mzSJr3SL23TIa3ULe3SJE3UKJ3TS93USG3UR13SSL3SPx3TTc3V Tl3VXz3VT33VM+3UKW3VaJ3War3WbN3Wbv3WcB3Xcj3XdF3XbY1ua43XRo1ueq3WfW3XgB3YIf3X eV3Ydk3YzcYE120dCAA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #333; PADDING-TOP: 0px; BACKGROUND-COLOR: #fff } H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DT { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .txt { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } FIELDSET { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; BORDER-TOP-STYLE: none! = important; PADDING-TOP: 0px! important; BORDER-RIGHT-STYLE: none! = important; BORDER-LEFT-STYLE: none! important; BORDER-BOTTOM-STYLE: = none! important } LEGEND { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.25em 0px 0.25em 1.25em; PADDING-TOP: 0px } DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .homepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .homepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .homepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .HomepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .HomepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .HomepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .HomepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } .HomepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } TABLE.menuIEFOUR { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; MARGIN: 0px; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURSIDE { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } TABLE.menuIEFOUR TD { FONT-WEIGHT: bold; FONT-SIZE: 70%; PADDING-BOTTOM: 0.2em; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; FONT-WEIGHT: normal; COLOR: white; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { FONT-WEIGHT: bold; FONT-SIZE: 0.7em; TEXT-TRANSFORM: uppercase; COLOR: = #6089b2; FONT-STYLE: normal } H3.navigationHeader EM { FONT-SIZE: 1.1em; COLOR: #ff9b06; FONT-STYLE: normal } .homepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .HomepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .homepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .HomepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } DIV.banner TABLE TD A { DISPLAY: block } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-REPEAT: repeat-y; BACKGROUND-COLOR: #13709d } UL.menuDOM LI { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: none; PADDING-BOTTOM: = 0.2em; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; BACKGROUND: white; = PADDING-BOTTOM: 0px; COLOR: white; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM LI UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuIEMAC { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM A { PADDING-RIGHT: 0.1em; DISPLAY: block; PADDING-LEFT: 0.1em; FONT-WEIGHT: = bold; PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } .hideNSFOUR LI A { WHITE-SPACE: normal } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } LI.nosaved EM { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuDOM LI UL { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover UL { BORDER-RIGHT: #90d7ff 1px solid; BORDER-TOP: #90d7ff 1px solid; = DISPLAY: block; Z-INDEX: 999; BACKGROUND: white; LEFT: auto; = MARGIN-LEFT: -1.25em; BORDER-LEFT: #90d7ff 1px solid; WIDTH: 200px; = BORDER-BOTTOM: #90d7ff 1px solid; TOP: auto; voice-family: inherit } UL.menuDOM LI IFRAME { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover IFRAME { Z-INDEX: 998; LEFT: auto; MARGIN-LEFT: -1.25em; WIDTH: 202px; TOP: auto } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-RIGHT: 5px; MARGIN-TOP: 0px! important; DISPLAY: block; = PADDING-LEFT: 5px; FONT-WEIGHT: bold; BACKGROUND: #ff9900; = PADDING-BOTTOM: 5px; WIDTH: 190px; COLOR: white! important; PADDING-TOP: = 5px; voice-family: inherit } LI.nosaved EM { FONT-WEIGHT: normal! important; COLOR: black! important; = TEXT-DECORATION: none! important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none! important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } .domArrowOut { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { DISPLAY: inline; PADDING-BOTTOM: 3px } UL.menuIEMAC LI UL { LEFT: -999em; POSITION: absolute } UL.menuIEMAC { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif)!= important; PADDING-BOTTOM: 0.1em; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } #user { PADDING-RIGHT: 2em; PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: = white } #mycart { PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: white } #menu { BORDER-RIGHT: transparent 1px solid; BORDER-TOP: transparent 1px solid; = BORDER-LEFT: transparent 1px solid; BORDER-BOTTOM: transparent 1px solid } .hideNSFOUR LI A { WHITE-SPACE: normal } .hideNSFOUR LI { WHITE-SPACE: normal } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.standards.css @import url( = http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { PADDING-LEFT: 1em; MARGIN: 0.25em 0em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-POSITION: 100% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.basic.gif); = BACKGROUND-REPEAT: no-repeat } #searchBox { BACKGROUND-POSITION: 0% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.search.gif); = BACKGROUND-REPEAT: no-repeat } #citationBox { BACKGROUND-POSITION: 0% 0%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.citation-finder.gif)= ; BACKGROUND-REPEAT: no-repeat } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { FONT-WEIGHT: bold; MARGIN: 0px; TEXT-ALIGN: right } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { COLOR: #f90; BORDER-BOTTOM: #ccc 2px solid } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { FONT-WEIGHT: normal; TEXT-ALIGN: left } #contentFrame .mainCol #footer { BORDER-TOP: #ccc 2px solid; MARGIN: 10px 10px 0px; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 7px; MARGIN: = 0px 0px 15px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; BORDER-LEFT-STYLE: none } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { MARGIN-TOP: 1px; BORDER-BOTTOM: #cce5ff 1px solid } #contentFrame .sideCol #citationBox .item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 0px 10px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .sideCol #relatedProducts UL { MARGIN-TOP: 0px; PADDING-BOTTOM: 8px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { PADDING-RIGHT: 0.5em; TEXT-ALIGN: right } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { FONT-WEIGHT: bold; COLOR: #9cf; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= WIDTH: 100%; BACKGROUND-REPEAT: repeat-y } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; WHITE-SPACE: nowrap } #personalnavSpecial { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0.5em; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-RIGHT: #069 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: #069 2px = solid; PADDING-LEFT: 2px; FONT-SIZE: 11pt; PADDING-BOTTOM: 2px; = BORDER-LEFT: #069 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #069 2px = solid; FONT-FAMILY: arial } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { LINE-HEIGHT: 140%; TEXT-ALIGN: center } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.home.jpg); = BACKGROUND-REPEAT: no-repeat; BACKGROUND-COLOR: #001941 } #logoCell { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.jpg); = BACKGROUND-REPEAT: no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; FONT-WEIGHT: bold; COLOR: #666 } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; BORDER-LEFT: = red 1px solid; BORDER-BOTTOM: red 1px solid; BACKGROUND-COLOR: #fcc } #browserWarning { BORDER-RIGHT: #c00 1px solid; PADDING-RIGHT: 0.3em; BORDER-TOP: #c00 = 1px solid; PADDING-LEFT: 0.3em; FONT-SIZE: 100%; PADDING-BOTTOM: 0.3em; = MARGIN: 5px 28px; BORDER-LEFT: #c00 1px solid; COLOR: #300; PADDING-TOP: = 0.3em; BORDER-BOTTOM: #c00 1px solid; FONT-FAMILY: arial; = BACKGROUND-COLOR: #fef } .invisible { OVERFLOW: hidden; WIDTH: 0px; POSITION: absolute; HEIGHT: 0px } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { FLOAT: left; MARGIN: 10px } .linkPrint { FLOAT: right; MARGIN: 10px 20px 0px 0px } .linkTop { CLEAR: both; TEXT-ALIGN: right } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { FONT-WEIGHT: bold; COLOR: #c00 } #errorList LI { FONT-WEIGHT: bold; COLOR: #c00! important; LIST-STYLE-TYPE: none } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #contentFrame #intro .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; PADDING-BOTTOM: 6px; MARGIN: = 10px 0px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { PADDING-LEFT: 2em; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -2em } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 8px; COLOR: #000; LINE-HEIGHT: = 150%; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalReferences .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { MARGIN: 0px; TEXT-ALIGN: center } #contentFrame #content .issueNav SPAN { FONT-WEIGHT: bold; COLOR: #f90 } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px 0.5em; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #ccc 1px solid } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-LEFT: 6px; PADDING-BOTTOM: 10px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none! important } .journalArticleMain #intro .item { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px! important } .journalArticleMain #searchBox { BORDER-RIGHT: #99c2d6 1px solid; WIDTH: 150px } .journalArticleMain #intro #searchBox .item { PADDING-RIGHT: 10px! important; PADDING-LEFT: 10px! important; = PADDING-BOTTOM: 10px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #565565; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #content .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content .prerendered TABLE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TH { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT A { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT[size=3D'+1'] { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #666 } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-WEIGHT: bold; FONT-SIZE: 14px } #contentFrame #content .prerendered FONT[size=3D'4'] A { FONT-SIZE: 14px; COLOR: #090 } #contentFrame #content .prerendered P { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; TEXT-TRANSFORM: = uppercase; COLOR: #f90 } .prerendered .firstLevelHeading { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .secondLevelHeading { DISPLAY: block; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { FONT-SIZE: 10pt; COLOR: #369 } .prerendered .referenceNum { FONT-SIZE: 10pt; COLOR: #369 } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/jquery.js /*=0A= * jQuery 1.2.6 - New Wave Javascript=0A= *=0A= * Copyright (c) 2008 John Resig (jquery.com)=0A= * Dual licensed under the MIT (MIT-LICENSE.txt)=0A= * and GPL (GPL-LICENSE.txt) licenses.=0A= *=0A= * $Date: 2008-07-02 17:45:25 +0100 (Wed, 02 Jul 2008) $=0A= * $Rev: 20679 $=0A= */=0A= (function(){var _jQuery=3Dwindow.jQuery,_$=3Dwindow.$;var = jQuery=3Dwindow.jQuery=3Dwindow.$=3Dfunction(selector,context){return = new jQuery.fn.init(selector,context);};var = quickExpr=3D/^[^<]*(<(.|\s)+>)[^>]*$|^#(\w+)$/,isSimple=3D/^.[^:#\[\.]*$/= ,undefined;jQuery.fn=3DjQuery.prototype=3D{init:function(selector,context= ){selector=3Dselector||document;if(selector.nodeType){this[0]=3Dselector;= this.length=3D1;return this;}if(typeof selector=3D=3D"string"){var = match=3DquickExpr.exec(selector);if(match&&(match[1]||!context)){if(match= [1])selector=3DjQuery.clean([match[1]],context);else{var = elem=3Ddocument.getElementById(match[3]);if(elem){if(elem.id!=3Dmatch[3])= return jQuery().find(selector);return jQuery(elem);}selector=3D[];}}else=0A= return jQuery(context).find(selector);}else = if(jQuery.isFunction(selector))return = jQuery(document)[jQuery.fn.ready?"ready":"load"](selector);return = this.setArray(jQuery.makeArray(selector));},jquery:"1.2.6",size:function(= ){return this.length;},length:0,get:function(num){return = num=3D=3Dundefined?jQuery.makeArray(this):this[num];},pushStack:function(= elems){var ret=3DjQuery(elems);ret.prevObject=3Dthis;return = ret;},setArray:function(elems){this.length=3D0;Array.prototype.push.apply= (this,elems);return this;},each:function(callback,args){return = jQuery.each(this,callback,args);},index:function(elem){var = ret=3D-1;return = jQuery.inArray(elem&&elem.jquery?elem[0]:elem,this);},attr:function(name,= value,type){var = options=3Dname;if(name.constructor=3D=3DString)if(value=3D=3D=3Dundefined= )return = this[0]&&jQuery[type||"attr"](this[0],name);else{options=3D{};options[nam= e]=3Dvalue;}return this.each(function(i){for(name in = options)jQuery.attr(type?this.style:this,name,jQuery.prop(this,options[na= me],type,i,name));});},css:function(key,value){if((key=3D=3D'width'||key=3D= =3D'height')&&parseFloat(value)<0)value=3Dundefined;return = this.attr(key,value,"curCSS");},text:function(text){if(typeof = text!=3D"object"&&text!=3Dnull)return = this.empty().append((this[0]&&this[0].ownerDocument||document).createText= Node(text));var = ret=3D"";jQuery.each(text||this,function(){jQuery.each(this.childNodes,fu= nction(){if(this.nodeType!=3D8)ret+=3Dthis.nodeType!=3D1?this.nodeValue:j= Query.fn.text([this]);});});return = ret;},wrapAll:function(html){if(this[0])jQuery(html,this[0].ownerDocument= ).clone().insertBefore(this[0]).map(function(){var = elem=3Dthis;while(elem.firstChild)elem=3Delem.firstChild;return = elem;}).append(this);return this;},wrapInner:function(html){return = this.each(function(){jQuery(this).contents().wrapAll(html);});},wrap:func= tion(html){return = this.each(function(){jQuery(this).wrapAll(html);});},append:function(){re= turn = this.domManip(arguments,true,false,function(elem){if(this.nodeType=3D=3D1= )this.appendChild(elem);});},prepend:function(){return = this.domManip(arguments,true,true,function(elem){if(this.nodeType=3D=3D1)= this.insertBefore(elem,this.firstChild);});},before:function(){return = this.domManip(arguments,false,false,function(elem){this.parentNode.insert= Before(elem,this);});},after:function(){return = this.domManip(arguments,false,true,function(elem){this.parentNode.insertB= efore(elem,this.nextSibling);});},end:function(){return = this.prevObject||jQuery([]);},find:function(selector){var = elems=3DjQuery.map(this,function(elem){return = jQuery.find(selector,elem);});return this.pushStack(/[^+>] = [^+>]/.test(selector)||selector.indexOf("..")>-1?jQuery.unique(elems):ele= ms);},clone:function(events){var = ret=3Dthis.map(function(){if(jQuery.browser.msie&&!jQuery.isXMLDoc(this))= {var = clone=3Dthis.cloneNode(true),container=3Ddocument.createElement("div");co= ntainer.appendChild(clone);return = jQuery.clean([container.innerHTML])[0];}else=0A= return this.cloneNode(true);});var = clone=3Dret.find("*").andSelf().each(function(){if(this[expando]!=3Dundef= ined)this[expando]=3Dnull;});if(events=3D=3D=3Dtrue)this.find("*").andSel= f().each(function(i){if(this.nodeType=3D=3D3)return;var = events=3DjQuery.data(this,"events");for(var type in events)for(var = handler in = events[type])jQuery.event.add(clone[i],type,events[type][handler],events[= type][handler].data);});return ret;},filter:function(selector){return = this.pushStack(jQuery.isFunction(selector)&&jQuery.grep(this,function(ele= m,i){return = selector.call(elem,i);})||jQuery.multiFilter(selector,this));},not:functi= on(selector){if(selector.constructor=3D=3DString)if(isSimple.test(selecto= r))return this.pushStack(jQuery.multiFilter(selector,this,true));else=0A= selector=3DjQuery.multiFilter(selector,this);var = isArrayLike=3Dselector.length&&selector[selector.length-1]!=3D=3Dundefine= d&&!selector.nodeType;return this.filter(function(){return = isArrayLike?jQuery.inArray(this,selector)<0:this!=3Dselector;});},add:fun= ction(selector){return = this.pushStack(jQuery.unique(jQuery.merge(this.get(),typeof = selector=3D=3D'string'?jQuery(selector):jQuery.makeArray(selector))));},i= s:function(selector){return!!selector&&jQuery.multiFilter(selector,this).= length>0;},hasClass:function(selector){return = this.is("."+selector);},val:function(value){if(value=3D=3Dundefined){if(t= his.length){var elem=3Dthis[0];if(jQuery.nodeName(elem,"select")){var = index=3Delem.selectedIndex,values=3D[],options=3Delem.options,one=3Delem.= type=3D=3D"select-one";if(index<0)return null;for(var = i=3Done?index:0,max=3Done?index+1:options.length;i=3D0||jQuery.inArray(this.name,value)>=3D0);else = if(jQuery.nodeName(this,"select")){var = values=3DjQuery.makeArray(value);jQuery("option",this).each(function(){th= is.selected=3D(jQuery.inArray(this.value,values)>=3D0||jQuery.inArray(thi= s.text,values)>=3D0);});if(!values.length)this.selectedIndex=3D-1;}else=0A= this.value=3Dvalue;});},html:function(value){return = value=3D=3Dundefined?(this[0]?this[0].innerHTML:null):this.empty().append= (value);},replaceWith:function(value){return = this.after(value).remove();},eq:function(i){return = this.slice(i,i+1);},slice:function(){return = this.pushStack(Array.prototype.slice.apply(this,arguments));},map:functio= n(callback){return = this.pushStack(jQuery.map(this,function(elem,i){return = callback.call(elem,i,elem);}));},andSelf:function(){return = this.add(this.prevObject);},data:function(key,value){var = parts=3Dkey.split(".");parts[1]=3Dparts[1]?"."+parts[1]:"";if(value=3D=3D= =3Dundefined){var = data=3Dthis.triggerHandler("getData"+parts[1]+"!",[parts[0]]);if(data=3D=3D= =3Dundefined&&this.length)data=3DjQuery.data(this[0],key);return = data=3D=3D=3Dundefined&&parts[1]?this.data(parts[0]):data;}else=0A= return = this.trigger("setData"+parts[1]+"!",[parts[0],value]).each(function(){jQu= ery.data(this,key,value);});},removeData:function(key){return = this.each(function(){jQuery.removeData(this,key);});},domManip:function(a= rgs,table,reverse,callback){var clone=3Dthis.length>1,elems;return = this.each(function(){if(!elems){elems=3DjQuery.clean(args,this.ownerDocum= ent);if(reverse)elems.reverse();}var = obj=3Dthis;if(table&&jQuery.nodeName(this,"table")&&jQuery.nodeName(elems= [0],"tr"))obj=3Dthis.getElementsByTagName("tbody")[0]||this.appendChild(t= his.ownerDocument.createElement("tbody"));var = scripts=3DjQuery([]);jQuery.each(elems,function(){var = elem=3Dclone?jQuery(this).clone(true)[0]:this;if(jQuery.nodeName(elem,"sc= ript"))scripts=3Dscripts.add(elem);else{if(elem.nodeType=3D=3D1)scripts=3D= scripts.add(jQuery("script",elem).remove());callback.call(obj,elem);}});s= cripts.each(evalScript);});}};jQuery.fn.init.prototype=3DjQuery.fn;functi= on = evalScript(i,elem){if(elem.src)jQuery.ajax({url:elem.src,async:false,data= Type:"script"});else=0A= jQuery.globalEval(elem.text||elem.textContent||elem.innerHTML||"");if(ele= m.parentNode)elem.parentNode.removeChild(elem);}function = now(){return+new Date;}jQuery.extend=3DjQuery.fn.extend=3Dfunction(){var = target=3Darguments[0]||{},i=3D1,length=3Darguments.length,deep=3Dfalse,op= tions;if(target.constructor=3D=3DBoolean){deep=3Dtarget;target=3Dargument= s[1]||{};i=3D2;}if(typeof target!=3D"object"&&typeof = target!=3D"function")target=3D{};if(length=3D=3Di){target=3Dthis;--i;}for= (;i= -1;}},swap:function(elem,options,callback){var old=3D{};for(var name in = options){old[name]=3Delem.style[name];elem.style[name]=3Doptions[name];}c= allback.call(elem);for(var name in = options)elem.style[name]=3Dold[name];},css:function(elem,name,force){if(n= ame=3D=3D"width"||name=3D=3D"height"){var = val,props=3D{position:"absolute",visibility:"hidden",display:"block"},whi= ch=3Dname=3D=3D"width"?["Left","Right"]:["Top","Bottom"];function = getWH(){val=3Dname=3D=3D"width"?elem.offsetWidth:elem.offsetHeight;var = padding=3D0,border=3D0;jQuery.each(which,function(){padding+=3DparseFloat= (jQuery.curCSS(elem,"padding"+this,true))||0;border+=3DparseFloat(jQuery.= curCSS(elem,"border"+this+"Width",true))||0;});val-=3DMath.round(padding+= border);}if(jQuery(elem).is(":visible"))getWH();else=0A= jQuery.swap(elem,props,getWH);return Math.max(0,val);}return = jQuery.curCSS(elem,name,force);},curCSS:function(elem,name,force){var = ret,style=3Delem.style;function = color(elem){if(!jQuery.browser.safari)return false;var = ret=3DdefaultView.getComputedStyle(elem,null);return!ret||ret.getProperty= Value("color")=3D=3D"";}if(name=3D=3D"opacity"&&jQuery.browser.msie){ret=3D= jQuery.attr(style,"opacity");return = ret=3D=3D""?"1":ret;}if(jQuery.browser.opera&&name=3D=3D"display"){var = save=3Dstyle.outline;style.outline=3D"0 solid = black";style.outline=3Dsave;}if(name.match(/float/i))name=3DstyleFloat;if= (!force&&style&&style[name])ret=3Dstyle[name];else = if(defaultView.getComputedStyle){if(name.match(/float/i))name=3D"float";n= ame=3Dname.replace(/([A-Z])/g,"-$1").toLowerCase();var = computedStyle=3DdefaultView.getComputedStyle(elem,null);if(computedStyle&= &!color(elem))ret=3DcomputedStyle.getPropertyValue(name);else{var = swap=3D[],stack=3D[],a=3Delem,i=3D0;for(;a&&color(a);a=3Da.parentNode)sta= ck.unshift(a);for(;i]*?)\/>/g,function(all= ,front,tag){return = tag.match(/^(abbr|br|col|img|input|link|meta|param|hr|area|embed)$/i)?all= :front+">";});var = tags=3DjQuery.trim(elem).toLowerCase(),div=3Dcontext.createElement("div")= ;var wrap=3D!tags.indexOf("",""]||!tags.indexOf("",""]||tags.match(/^<(thead|tbody|tfoot|colg|cap)/)&&[1,"",""]||!tags.indexOf("",""]||(!tags.indexOf("= ",""]||!tags.indexOf("= ",""]||jQuery.browser.msie&&[1,"div<= div>",""]||[0,"",""];div.innerHTML=3Dwrap[1]+elem+wrap[2];while(wra= p[0]--)div=3Ddiv.lastChild;if(jQuery.browser.msie){var = tbody=3D!tags.indexOf(""&&tags.indexOf("=3D0;--j)if(jQuery.nodeName(tbody[j],"tbody")&&!tbod= y[j].childNodes.length)tbody[j].parentNode.removeChild(tbody[j]);if(/^\s/= .test(elem))div.insertBefore(context.createTextNode(elem.match(/^\s*/)[0]= ),div.firstChild);}elem=3DjQuery.makeArray(div.childNodes);}if(elem.lengt= h=3D=3D=3D0&&(!jQuery.nodeName(elem,"form")&&!jQuery.nodeName(elem,"selec= t")))return;if(elem[0]=3D=3Dundefined||jQuery.nodeName(elem,"form")||elem= .options)ret.push(elem);else=0A= ret=3DjQuery.merge(ret,elem);});return = ret;},attr:function(elem,name,value){if(!elem||elem.nodeType=3D=3D3||elem= .nodeType=3D=3D8)return undefined;var = notxml=3D!jQuery.isXMLDoc(elem),set=3Dvalue!=3D=3Dundefined,msie=3DjQuery= .browser.msie;name=3Dnotxml&&jQuery.props[name]||name;if(elem.tagName){va= r = special=3D/href|src|style/.test(name);if(name=3D=3D"selected"&&jQuery.bro= wser.safari)elem.parentNode.selectedIndex;if(name in = elem&¬xml&&!special){if(set){if(name=3D=3D"type"&&jQuery.nodeName(elem= ,"input")&&elem.parentNode)throw"type property can't be = changed";elem[name]=3Dvalue;}if(jQuery.nodeName(elem,"form")&&elem.getAtt= ributeNode(name))return elem.getAttributeNode(name).nodeValue;return = elem[name];}if(msie&¬xml&&name=3D=3D"style")return = jQuery.attr(elem.style,"cssText",value);if(set)elem.setAttribute(name,""+= value);var = attr=3Dmsie&¬xml&&special?elem.getAttribute(name,2):elem.getAttribute(= name);return = attr=3D=3D=3Dnull?undefined:attr;}if(msie&&name=3D=3D"opacity"){if(set){e= lem.zoom=3D1;elem.filter=3D(elem.filter||"").replace(/alpha\([^)]*\)/,"")= +(parseInt(value)+''=3D=3D"NaN"?"":"alpha(opacity=3D"+value*100+")");}ret= urn = elem.filter&&elem.filter.indexOf("opacity=3D")>=3D0?(parseFloat(elem.filt= er.match(/opacity=3D([^)]*)/)[1])/100)+'':"";}name=3Dname.replace(/-([a-z= ])/ig,function(all,letter){return = letter.toUpperCase();});if(set)elem[name]=3Dvalue;return = elem[name];},trim:function(text){return(text||"").replace(/^\s+|\s+$/g,""= );},makeArray:function(array){var ret=3D[];if(array!=3Dnull){var = i=3Darray.length;if(i=3D=3Dnull||array.split||array.setInterval||array.ca= ll)ret[0]=3Darray;else=0A= while(i)ret[--i]=3Darray[i];}return = ret;},inArray:function(elem,array){for(var = i=3D0,length=3Darray.length;i*",t= his).remove();while(this.firstChild)this.removeChild(this.firstChild);}},= function(name,fn){jQuery.fn[name]=3Dfunction(){return = this.each(fn,arguments);};});jQuery.each(["Height","Width"],function(i,na= me){var = type=3Dname.toLowerCase();jQuery.fn[type]=3Dfunction(size){return = this[0]=3D=3Dwindow?jQuery.browser.opera&&document.body["client"+name]||j= Query.browser.safari&&window["inner"+name]||document.compatMode=3D=3D"CSS= 1Compat"&&document.documentElement["client"+name]||document.body["client"= +name]:this[0]=3D=3Ddocument?Math.max(Math.max(document.body["scroll"+nam= e],document.documentElement["scroll"+name]),Math.max(document.body["offse= t"+name],document.documentElement["offset"+name])):size=3D=3Dundefined?(t= his.length?jQuery.css(this[0],type):null):this.css(type,size.constructor=3D= =3DString?size:size+"px");};});function num(elem,prop){return = elem[0]&&parseInt(jQuery.curCSS(elem[0],prop,true),10)||0;}var = chars=3DjQuery.browser.safari&&parseInt(jQuery.browser.version)<417?"(?:[= \\w*_-]|\\\\.)":"(?:[\\w\u0128-\uFFFF*_-]|\\\\.)",quickChild=3Dnew = RegExp("^>\\s*("+chars+"+)"),quickID=3Dnew = RegExp("^("+chars+"+)(#)("+chars+"+)"),quickClass=3Dnew = RegExp("^([#.]?)("+chars+"*)");jQuery.extend({expr:{"":function(a,i,m){re= turn m[2]=3D=3D"*"||jQuery.nodeName(a,m[2]);},"#":function(a,i,m){return = a.getAttribute("id")=3D=3Dm[2];},":":{lt:function(a,i,m){return = im[3]-0;},nth:function(a,i,m){return = m[3]-0=3D=3Di;},eq:function(a,i,m){return = m[3]-0=3D=3Di;},first:function(a,i){return = i=3D=3D0;},last:function(a,i,m,r){return = i=3D=3Dr.length-1;},even:function(a,i){return = i%2=3D=3D0;},odd:function(a,i){return = i%2;},"first-child":function(a){return = a.parentNode.getElementsByTagName("*")[0]=3D=3Da;},"last-child":function(= a){return = jQuery.nth(a.parentNode.lastChild,1,"previousSibling")=3D=3Da;},"only-chi= ld":function(a){return!jQuery.nth(a.parentNode.lastChild,2,"previousSibli= ng");},parent:function(a){return = a.firstChild;},empty:function(a){return!a.firstChild;},contains:function(= a,i,m){return(a.textContent||a.innerText||jQuery(a).text()||"").indexOf(m= [3])>=3D0;},visible:function(a){return"hidden"!=3Da.type&&jQuery.css(a,"d= isplay")!=3D"none"&&jQuery.css(a,"visibility")!=3D"hidden";},hidden:funct= ion(a){return"hidden"=3D=3Da.type||jQuery.css(a,"display")=3D=3D"none"||j= Query.css(a,"visibility")=3D=3D"hidden";},enabled:function(a){return!a.di= sabled;},disabled:function(a){return = a.disabled;},checked:function(a){return = a.checked;},selected:function(a){return = a.selected||jQuery.attr(a,"selected");},text:function(a){return"text"=3D=3D= a.type;},radio:function(a){return"radio"=3D=3Da.type;},checkbox:function(= a){return"checkbox"=3D=3Da.type;},file:function(a){return"file"=3D=3Da.ty= pe;},password:function(a){return"password"=3D=3Da.type;},submit:function(= a){return"submit"=3D=3Da.type;},image:function(a){return"image"=3D=3Da.ty= pe;},reset:function(a){return"reset"=3D=3Da.type;},button:function(a){ret= urn"button"=3D=3Da.type||jQuery.nodeName(a,"button");},input:function(a){= return/input|select|textarea|button/i.test(a.nodeName);},has:function(a,i= ,m){return = jQuery.find(m[3],a).length;},header:function(a){return/h\d/i.test(a.nodeN= ame);},animated:function(a){return = jQuery.grep(jQuery.timers,function(fn){return = a=3D=3Dfn.elem;}).length;}}},parse:[/^(\[) *@?([\w-]+) *([!*$^~=3D]*) = *('?"?)(.*?)\4 *\]/,/^(:)([\w-]+)\("?'?(.*?(\(.*?\))?[^(]*?)"?'?\)/,new = RegExp("^([:.#]*)("+chars+"+)")],multiFilter:function(expr,elems,not){var= old,cur=3D[];while(expr&&expr!=3Dold){old=3Dexpr;var = f=3DjQuery.filter(expr,elems,not);expr=3Df.t.replace(/^\s*,\s*/,"");cur=3D= not?elems=3Df.r:jQuery.merge(cur,f.r);}return = cur;},find:function(t,context){if(typeof = t!=3D"string")return[t];if(context&&context.nodeType!=3D1&&context.nodeTy= pe!=3D9)return[];context=3Dcontext||document;var = ret=3D[context],done=3D[],last,nodeName;while(t&&last!=3Dt){var = r=3D[];last=3Dt;t=3DjQuery.trim(t);var = foundToken=3Dfalse,re=3DquickChild,m=3Dre.exec(t);if(m){nodeName=3Dm[1].t= oUpperCase();for(var i=3D0;ret[i];i++)for(var = c=3Dret[i].firstChild;c;c=3Dc.nextSibling)if(c.nodeType=3D=3D1&&(nodeName= =3D=3D"*"||c.nodeName.toUpperCase()=3D=3DnodeName))r.push(c);ret=3Dr;t=3D= t.replace(re,"");if(t.indexOf(" = ")=3D=3D0)continue;foundToken=3Dtrue;}else{re=3D/^([>+~])\s*(\w*)/i;if((m= =3Dre.exec(t))!=3Dnull){r=3D[];var = merge=3D{};nodeName=3Dm[2].toUpperCase();m=3Dm[1];for(var = j=3D0,rl=3Dret.length;j=3D0)^not)tmp.= push(a);}r=3Dtmp;}else if(m[1]=3D=3D":"&&m[2]=3D=3D"nth-child"){var = merge=3D{},tmp=3D[],test=3D/(-?)(\d*)n((?:\+|-)?\d*)/.exec(m[3]=3D=3D"eve= n"&&"2n"||m[3]=3D=3D"odd"&&"2n+1"||!/\D/.test(m[3])&&"0n+"+m[3]||m[3]),fi= rst=3D(test[1]+(test[2]||1))-0,last=3Dtest[3]-0;for(var = i=3D0,rl=3Dr.length;i=3D0)a= dd=3Dtrue;if(add^not)tmp.push(node);}r=3Dtmp;}else{var = fn=3DjQuery.expr[m[1]];if(typeof = fn=3D=3D"object")fn=3Dfn[m[2]];if(typeof = fn=3D=3D"string")fn=3Deval("false||function(a,i){return = "+fn+";}");r=3DjQuery.grep(r,function(elem,i){return = fn(elem,i,m,r);},not);}}return{r:r,t:t};},dir:function(elem,dir){var = matched=3D[],cur=3Delem[dir];while(cur&&cur!=3Ddocument){if(cur.nodeType=3D= =3D1)matched.push(cur);cur=3Dcur[dir];}return = matched;},nth:function(cur,result,dir,elem){result=3Dresult||1;var = num=3D0;for(;cur;cur=3Dcur[dir])if(cur.nodeType=3D=3D1&&++num=3D=3Dresult= )break;return cur;},sibling:function(n,elem){var = r=3D[];for(;n;n=3Dn.nextSibling){if(n.nodeType=3D=3D1&&n!=3Delem)r.push(n= );}return = r;}});jQuery.event=3D{add:function(elem,types,handler,data){if(elem.nodeT= ype=3D=3D3||elem.nodeType=3D=3D8)return;if(jQuery.browser.msie&&elem.setI= nterval)elem=3Dwindow;if(!handler.guid)handler.guid=3Dthis.guid++;if(data= !=3Dundefined){var = fn=3Dhandler;handler=3Dthis.proxy(fn,function(){return = fn.apply(this,arguments);});handler.data=3Ddata;}var = events=3DjQuery.data(elem,"events")||jQuery.data(elem,"events",{}),handle= =3DjQuery.data(elem,"handle")||jQuery.data(elem,"handle",function(){if(ty= peof jQuery!=3D"undefined"&&!jQuery.event.triggered)return = jQuery.event.handle.apply(arguments.callee.elem,arguments);});handle.elem= =3Delem;jQuery.each(types.split(/\s+/),function(index,type){var = parts=3Dtype.split(".");type=3Dparts[0];handler.type=3Dparts[1];var = handlers=3Devents[type];if(!handlers){handlers=3Devents[type]=3D{};if(!jQ= uery.event.special[type]||jQuery.event.special[type].setup.call(elem)=3D=3D= =3Dfalse){if(elem.addEventListener)elem.addEventListener(type,handle,fals= e);else = if(elem.attachEvent)elem.attachEvent("on"+type,handle);}}handlers[handler= .guid]=3Dhandler;jQuery.event.global[type]=3Dtrue;});elem=3Dnull;},guid:1= ,global:{},remove:function(elem,types,handler){if(elem.nodeType=3D=3D3||e= lem.nodeType=3D=3D8)return;var = events=3DjQuery.data(elem,"events"),ret,index;if(events){if(types=3D=3Dun= defined||(typeof types=3D=3D"string"&&types.charAt(0)=3D=3D"."))for(var = type in = events)this.remove(elem,type+(types||""));else{if(types.type){handler=3Dt= ypes.handler;types=3Dtypes.type;}jQuery.each(types.split(/\s+/),function(= index,type){var = parts=3Dtype.split(".");type=3Dparts[0];if(events[type]){if(handler)delet= e events[type][handler.guid];else=0A= for(handler in = events[type])if(!parts[1]||events[type][handler].type=3D=3Dparts[1])delet= e events[type][handler];for(ret in = events[type])break;if(!ret){if(!jQuery.event.special[type]||jQuery.event.= special[type].teardown.call(elem)=3D=3D=3Dfalse){if(elem.removeEventListe= ner)elem.removeEventListener(type,jQuery.data(elem,"handle"),false);else = if(elem.detachEvent)elem.detachEvent("on"+type,jQuery.data(elem,"handle")= );}ret=3Dnull;delete events[type];}}});}for(ret in = events)break;if(!ret){var = handle=3DjQuery.data(elem,"handle");if(handle)handle.elem=3Dnull;jQuery.r= emoveData(elem,"events");jQuery.removeData(elem,"handle");}}},trigger:fun= ction(type,data,elem,donative,extra){data=3DjQuery.makeArray(data);if(typ= e.indexOf("!")>=3D0){type=3Dtype.slice(0,-1);var = exclusive=3Dtrue;}if(!elem){if(this.global[type])jQuery("*").add([window,= document]).trigger(type,data);}else{if(elem.nodeType=3D=3D3||elem.nodeTyp= e=3D=3D8)return undefined;var = val,ret,fn=3DjQuery.isFunction(elem[type]||null),event=3D!data[0]||!data[= 0].preventDefault;if(event){data.unshift({type:type,target:elem,preventDe= fault:function(){},stopPropagation:function(){},timeStamp:now()});data[0]= [expando]=3Dtrue;}data[0].type=3Dtype;if(exclusive)data[0].exclusive=3Dtr= ue;var = handle=3DjQuery.data(elem,"handle");if(handle)val=3Dhandle.apply(elem,dat= a);if((!fn||(jQuery.nodeName(elem,'a')&&type=3D=3D"click"))&&elem["on"+ty= pe]&&elem["on"+type].apply(elem,data)=3D=3D=3Dfalse)val=3Dfalse;if(event)= data.shift();if(extra&&jQuery.isFunction(extra)){ret=3Dextra.apply(elem,v= al=3D=3Dnull?data:data.concat(val));if(ret!=3D=3Dundefined)val=3Dret;}if(= fn&&donative!=3D=3Dfalse&&val!=3D=3Dfalse&&!(jQuery.nodeName(elem,'a')&&t= ype=3D=3D"click")){this.triggered=3Dtrue;try{elem[type]();}catch(e){}}thi= s.triggered=3Dfalse;}return val;},handle:function(event){var = val,ret,namespace,all,handlers;event=3Darguments[0]=3DjQuery.event.fix(ev= ent||window.event);namespace=3Devent.type.split(".");event.type=3Dnamespa= ce[0];namespace=3Dnamespace[1];all=3D!namespace&&!event.exclusive;handler= s=3D(jQuery.data(this,"events")||{})[event.type];for(var j in = handlers){var = handler=3Dhandlers[j];if(all||handler.type=3D=3Dnamespace){event.handler=3D= handler;event.data=3Dhandler.data;ret=3Dhandler.apply(this,arguments);if(= val!=3D=3Dfalse)val=3Dret;if(ret=3D=3D=3Dfalse){event.preventDefault();ev= ent.stopPropagation();}}}return = val;},fix:function(event){if(event[expando]=3D=3Dtrue)return event;var = originalEvent=3Devent;event=3D{originalEvent:originalEvent};var = props=3D"altKey attrChange attrName bubbles button cancelable charCode = clientX clientY ctrlKey currentTarget data detail eventPhase fromElement = handler keyCode metaKey newValue originalTarget pageX pageY prevValue = relatedNode relatedTarget screenX screenY shiftKey srcElement target = timeStamp toElement type view wheelDelta which".split(" ");for(var = i=3Dprops.length;i;i--)event[props[i]]=3DoriginalEvent[props[i]];event[ex= pando]=3Dtrue;event.preventDefault=3Dfunction(){if(originalEvent.preventD= efault)originalEvent.preventDefault();originalEvent.returnValue=3Dfalse;}= ;event.stopPropagation=3Dfunction(){if(originalEvent.stopPropagation)orig= inalEvent.stopPropagation();originalEvent.cancelBubble=3Dtrue;};event.tim= eStamp=3Devent.timeStamp||now();if(!event.target)event.target=3Devent.src= Element||document;if(event.target.nodeType=3D=3D3)event.target=3Devent.ta= rget.parentNode;if(!event.relatedTarget&&event.fromElement)event.relatedT= arget=3Devent.fromElement=3D=3Devent.target?event.toElement:event.fromEle= ment;if(event.pageX=3D=3Dnull&&event.clientX!=3Dnull){var = doc=3Ddocument.documentElement,body=3Ddocument.body;event.pageX=3Devent.c= lientX+(doc&&doc.scrollLeft||body&&body.scrollLeft||0)-(doc.clientLeft||0= );event.pageY=3Devent.clientY+(doc&&doc.scrollTop||body&&body.scrollTop||= 0)-(doc.clientTop||0);}if(!event.which&&((event.charCode||event.charCode=3D= =3D=3D0)?event.charCode:event.keyCode))event.which=3Devent.charCode||even= t.keyCode;if(!event.metaKey&&event.ctrlKey)event.metaKey=3Devent.ctrlKey;= if(!event.which&&event.button)event.which=3D(event.button&1?1:(event.butt= on&2?3:(event.button&4?2:0)));return = event;},proxy:function(fn,proxy){proxy.guid=3Dfn.guid=3Dfn.guid||proxy.gu= id||this.guid++;return = proxy;},special:{ready:{setup:function(){bindReady();return;},teardown:fu= nction(){return;}},mouseenter:{setup:function(){if(jQuery.browser.msie)re= turn = false;jQuery(this).bind("mouseover",jQuery.event.special.mouseenter.handl= er);return true;},teardown:function(){if(jQuery.browser.msie)return = false;jQuery(this).unbind("mouseover",jQuery.event.special.mouseenter.han= dler);return = true;},handler:function(event){if(withinElement(event,this))return = true;event.type=3D"mouseenter";return = jQuery.event.handle.apply(this,arguments);}},mouseleave:{setup:function()= {if(jQuery.browser.msie)return = false;jQuery(this).bind("mouseout",jQuery.event.special.mouseleave.handle= r);return true;},teardown:function(){if(jQuery.browser.msie)return = false;jQuery(this).unbind("mouseout",jQuery.event.special.mouseleave.hand= ler);return = true;},handler:function(event){if(withinElement(event,this))return = true;event.type=3D"mouseleave";return = jQuery.event.handle.apply(this,arguments);}}}};jQuery.fn.extend({bind:fun= ction(type,data,fn){return = type=3D=3D"unload"?this.one(type,data,fn):this.each(function(){jQuery.eve= nt.add(this,type,fn||data,fn&&data);});},one:function(type,data,fn){var = one=3DjQuery.event.proxy(fn||data,function(event){jQuery(this).unbind(eve= nt,one);return(fn||data).apply(this,arguments);});return = this.each(function(){jQuery.event.add(this,type,one,fn&&data);});},unbind= :function(type,fn){return = this.each(function(){jQuery.event.remove(this,type,fn);});},trigger:funct= ion(type,data,fn){return = this.each(function(){jQuery.event.trigger(type,data,this,true,fn);});},tr= iggerHandler:function(type,data,fn){return = this[0]&&jQuery.event.trigger(type,data,this[0],false,fn);},toggle:functi= on(fn){var = args=3Darguments,i=3D1;while(i=3D0){var = selector=3Durl.slice(off,url.length);url=3Durl.slice(0,off);}callback=3Dc= allback||function(){};var = type=3D"GET";if(params)if(jQuery.isFunction(params)){callback=3Dparams;pa= rams=3Dnull;}else{params=3DjQuery.param(params);type=3D"POST";}var = self=3Dthis;jQuery.ajax({url:url,type:type,dataType:"html",data:params,co= mplete:function(res,status){if(status=3D=3D"success"||status=3D=3D"notmod= ified")self.html(selector?jQuery("

").append(res.responseText.replac= e(//g,"")).find(selector):res.responseText);self.= each(callback,[res.responseText,status,res]);}});return = this;},serialize:function(){return = jQuery.param(this.serializeArray());},serializeArray:function(){return = this.map(function(){return = jQuery.nodeName(this,"form")?jQuery.makeArray(this.elements):this;}).filt= er(function(){return = this.name&&!this.disabled&&(this.checked||/select|textarea/i.test(this.no= deName)||/text|hidden|password/i.test(this.type));}).map(function(i,elem)= {var val=3DjQuery(this).val();return = val=3D=3Dnull?null:val.constructor=3D=3DArray?jQuery.map(val,function(val= ,i){return{name:elem.name,value:val};}):{name:elem.name,value:val};}).get= ();}});jQuery.each("ajaxStart,ajaxStop,ajaxComplete,ajaxError,ajaxSuccess= ,ajaxSend".split(","),function(i,o){jQuery.fn[o]=3Dfunction(f){return = this.bind(o,f);};});var = jsc=3Dnow();jQuery.extend({get:function(url,data,callback,type){if(jQuery= .isFunction(data)){callback=3Ddata;data=3Dnull;}return = jQuery.ajax({type:"GET",url:url,data:data,success:callback,dataType:type}= );},getScript:function(url,callback){return = jQuery.get(url,null,callback,"script");},getJSON:function(url,data,callba= ck){return = jQuery.get(url,data,callback,"json");},post:function(url,data,callback,ty= pe){if(jQuery.isFunction(data)){callback=3Ddata;data=3D{};}return = jQuery.ajax({type:"POST",url:url,data:data,success:callback,dataType:type= });},ajaxSetup:function(settings){jQuery.extend(jQuery.ajaxSettings,setti= ngs);},ajaxSettings:{url:location.href,global:true,type:"GET",timeout:0,c= ontentType:"application/x-www-form-urlencoded",processData:true,async:tru= e,data:null,username:null,password:null,accepts:{xml:"application/xml, = text/xml",html:"text/html",script:"text/javascript, = application/javascript",json:"application/json, = text/javascript",text:"text/plain",_default:"*/*"}},lastModified:{},ajax:= function(s){s=3DjQuery.extend(true,s,jQuery.extend(true,{},jQuery.ajaxSet= tings,s));var = jsonp,jsre=3D/=3D\?(&|$)/g,status,data,type=3Ds.type.toUpperCase();if(s.d= ata&&s.processData&&typeof = s.data!=3D"string")s.data=3DjQuery.param(s.data);if(s.dataType=3D=3D"json= p"){if(type=3D=3D"GET"){if(!s.url.match(jsre))s.url+=3D(s.url.match(/\?/)= ?"&":"?")+(s.jsonp||"callback")+"=3D?";}else = if(!s.data||!s.data.match(jsre))s.data=3D(s.data?s.data+"&":"")+(s.jsonp|= |"callback")+"=3D?";s.dataType=3D"json";}if(s.dataType=3D=3D"json"&&(s.da= ta&&s.data.match(jsre)||s.url.match(jsre))){jsonp=3D"jsonp"+jsc++;if(s.da= ta)s.data=3D(s.data+"").replace(jsre,"=3D"+jsonp+"$1");s.url=3Ds.url.repl= ace(jsre,"=3D"+jsonp+"$1");s.dataType=3D"script";window[jsonp]=3Dfunction= (tmp){data=3Dtmp;success();complete();window[jsonp]=3Dundefined;try{delet= e = window[jsonp];}catch(e){}if(head)head.removeChild(script);};}if(s.dataTyp= e=3D=3D"script"&&s.cache=3D=3Dnull)s.cache=3Dfalse;if(s.cache=3D=3D=3Dfal= se&&type=3D=3D"GET"){var ts=3Dnow();var = ret=3Ds.url.replace(/(\?|&)_=3D.*?(&|$)/,"$1_=3D"+ts+"$2");s.url=3Dret+((= ret=3D=3Ds.url)?(s.url.match(/\?/)?"&":"?")+"_=3D"+ts:"");}if(s.data&&typ= e=3D=3D"GET"){s.url+=3D(s.url.match(/\?/)?"&":"?")+s.data;s.data=3Dnull;}= if(s.global&&!jQuery.active++)jQuery.event.trigger("ajaxStart");var = remote=3D/^(?:\w+:)?\/\/([^\/?#]+)/;if(s.dataType=3D=3D"script"&&type=3D=3D= "GET"&&remote.test(s.url)&&remote.exec(s.url)[1]!=3Dlocation.host){var = head=3Ddocument.getElementsByTagName("head")[0];var = script=3Ddocument.createElement("script");script.src=3Ds.url;if(s.scriptC= harset)script.charset=3Ds.scriptCharset;if(!jsonp){var = done=3Dfalse;script.onload=3Dscript.onreadystatechange=3Dfunction(){if(!d= one&&(!this.readyState||this.readyState=3D=3D"loaded"||this.readyState=3D= =3D"complete")){done=3Dtrue;success();complete();head.removeChild(script)= ;}};}head.appendChild(script);return undefined;}var = requestDone=3Dfalse;var xhr=3Dwindow.ActiveXObject?new = ActiveXObject("Microsoft.XMLHTTP"):new = XMLHttpRequest();if(s.username)xhr.open(type,s.url,s.async,s.username,s.p= assword);else=0A= xhr.open(type,s.url,s.async);try{if(s.data)xhr.setRequestHeader("Content-= Type",s.contentType);if(s.ifModified)xhr.setRequestHeader("If-Modified-Si= nce",jQuery.lastModified[s.url]||"Thu, 01 Jan 1970 00:00:00 = GMT");xhr.setRequestHeader("X-Requested-With","XMLHttpRequest");xhr.setRe= questHeader("Accept",s.dataType&&s.accepts[s.dataType]?s.accepts[s.dataTy= pe]+", = */*":s.accepts._default);}catch(e){}if(s.beforeSend&&s.beforeSend(xhr,s)=3D= =3D=3Dfalse){s.global&&jQuery.active--;xhr.abort();return = false;}if(s.global)jQuery.event.trigger("ajaxSend",[xhr,s]);var = onreadystatechange=3Dfunction(isTimeout){if(!requestDone&&xhr&&(xhr.ready= State=3D=3D4||isTimeout=3D=3D"timeout")){requestDone=3Dtrue;if(ival){clea= rInterval(ival);ival=3Dnull;}status=3DisTimeout=3D=3D"timeout"&&"timeout"= ||!jQuery.httpSuccess(xhr)&&"error"||s.ifModified&&jQuery.httpNotModified= (xhr,s.url)&&"notmodified"||"success";if(status=3D=3D"success"){try{data=3D= jQuery.httpData(xhr,s.dataType,s.dataFilter);}catch(e){status=3D"parserer= ror";}}if(status=3D=3D"success"){var = modRes;try{modRes=3Dxhr.getResponseHeader("Last-Modified");}catch(e){}if(= s.ifModified&&modRes)jQuery.lastModified[s.url]=3DmodRes;if(!jsonp)succes= s();}else=0A= jQuery.handleError(s,xhr,status);complete();if(s.async)xhr=3Dnull;}};if(s= .async){var = ival=3DsetInterval(onreadystatechange,13);if(s.timeout>0)setTimeout(funct= ion(){if(xhr){xhr.abort();if(!requestDone)onreadystatechange("timeout");}= },s.timeout);}try{xhr.send(s.data);}catch(e){jQuery.handleError(s,xhr,nul= l,e);}if(!s.async)onreadystatechange();function = success(){if(s.success)s.success(data,status);if(s.global)jQuery.event.tr= igger("ajaxSuccess",[xhr,s]);}function = complete(){if(s.complete)s.complete(xhr,status);if(s.global)jQuery.event.= trigger("ajaxComplete",[xhr,s]);if(s.global&&!--jQuery.active)jQuery.even= t.trigger("ajaxStop");}return = xhr;},handleError:function(s,xhr,status,e){if(s.error)s.error(xhr,status,= e);if(s.global)jQuery.event.trigger("ajaxError",[xhr,s,e]);},active:0,htt= pSuccess:function(xhr){try{return!xhr.status&&location.protocol=3D=3D"fil= e:"||(xhr.status>=3D200&&xhr.status<300)||xhr.status=3D=3D304||xhr.status= =3D=3D1223||jQuery.browser.safari&&xhr.status=3D=3Dundefined;}catch(e){}r= eturn false;},httpNotModified:function(xhr,url){try{var = xhrRes=3Dxhr.getResponseHeader("Last-Modified");return = xhr.status=3D=3D304||xhrRes=3D=3DjQuery.lastModified[url]||jQuery.browser= .safari&&xhr.status=3D=3Dundefined;}catch(e){}return = false;},httpData:function(xhr,type,filter){var = ct=3Dxhr.getResponseHeader("content-type"),xml=3Dtype=3D=3D"xml"||!type&&= ct&&ct.indexOf("xml")>=3D0,data=3Dxml?xhr.responseXML:xhr.responseText;if= (xml&&data.documentElement.tagName=3D=3D"parsererror")throw"parsererror";= if(filter)data=3Dfilter(data,type);if(type=3D=3D"script")jQuery.globalEva= l(data);if(type=3D=3D"json")data=3Deval("("+data+")");return = data;},param:function(a){var = s=3D[];if(a.constructor=3D=3DArray||a.jquery)jQuery.each(a,function(){s.p= ush(encodeURIComponent(this.name)+"=3D"+encodeURIComponent(this.value));}= );else=0A= for(var j in = a)if(a[j]&&a[j].constructor=3D=3DArray)jQuery.each(a[j],function(){s.push= (encodeURIComponent(j)+"=3D"+encodeURIComponent(this));});else=0A= s.push(encodeURIComponent(j)+"=3D"+encodeURIComponent(jQuery.isFunction(a= [j])?a[j]():a[j]));return = s.join("&").replace(/%20/g,"+");}});jQuery.fn.extend({show:function(speed= ,callback){return = speed?this.animate({height:"show",width:"show",opacity:"show"},speed,call= back):this.filter(":hidden").each(function(){this.style.display=3Dthis.ol= dblock||"";if(jQuery.css(this,"display")=3D=3D"none"){var = elem=3DjQuery("<"+this.tagName+" = />").appendTo("body");this.style.display=3Delem.css("display");if(this.st= yle.display=3D=3D"none")this.style.display=3D"block";elem.remove();}}).en= d();},hide:function(speed,callback){return = speed?this.animate({height:"hide",width:"hide",opacity:"hide"},speed,call= back):this.filter(":visible").each(function(){this.oldblock=3Dthis.oldblo= ck||jQuery.css(this,"display");this.style.display=3D"none";}).end();},_to= ggle:jQuery.fn.toggle,toggle:function(fn,fn2){return = jQuery.isFunction(fn)&&jQuery.isFunction(fn2)?this._toggle.apply(this,arg= uments):fn?this.animate({height:"toggle",width:"toggle",opacity:"toggle"}= ,fn,fn2):this.each(function(){jQuery(this)[jQuery(this).is(":hidden")?"sh= ow":"hide"]();});},slideDown:function(speed,callback){return = this.animate({height:"show"},speed,callback);},slideUp:function(speed,cal= lback){return = this.animate({height:"hide"},speed,callback);},slideToggle:function(speed= ,callback){return = this.animate({height:"toggle"},speed,callback);},fadeIn:function(speed,ca= llback){return = this.animate({opacity:"show"},speed,callback);},fadeOut:function(speed,ca= llback){return = this.animate({opacity:"hide"},speed,callback);},fadeTo:function(speed,to,= callback){return = this.animate({opacity:to},speed,callback);},animate:function(prop,speed,e= asing,callback){var optall=3DjQuery.speed(speed,easing,callback);return = this[optall.queue=3D=3D=3Dfalse?"each":"queue"](function(){if(this.nodeTy= pe!=3D1)return false;var = opt=3DjQuery.extend({},optall),p,hidden=3DjQuery(this).is(":hidden"),self= =3Dthis;for(p in = prop){if(prop[p]=3D=3D"hide"&&hidden||prop[p]=3D=3D"show"&&!hidden)return= = opt.complete.call(this);if(p=3D=3D"height"||p=3D=3D"width"){opt.display=3D= jQuery.css(this,"display");opt.overflow=3Dthis.style.overflow;}}if(opt.ov= erflow!=3Dnull)this.style.overflow=3D"hidden";opt.curAnim=3DjQuery.extend= ({},prop);jQuery.each(prop,function(name,val){var e=3Dnew = jQuery.fx(self,opt,name);if(/toggle|show|hide/.test(val))e[val=3D=3D"togg= le"?hidden?"show":"hide":val](prop);else{var = parts=3Dval.toString().match(/^([+-]=3D)?([\d+-.]+)(.*)$/),start=3De.cur(= true)||0;if(parts){var = end=3DparseFloat(parts[2]),unit=3Dparts[3]||"px";if(unit!=3D"px"){self.st= yle[name]=3D(end||1)+unit;start=3D((end||1)/e.cur(true))*start;self.style= [name]=3Dstart+unit;}if(parts[1])end=3D((parts[1]=3D=3D"-=3D"?-1:1)*end)+= start;e.custom(start,end,unit);}else=0A= e.custom(start,val,"");}});return = true;});},queue:function(type,fn){if(jQuery.isFunction(type)||(type&&type= .constructor=3D=3DArray)){fn=3Dtype;type=3D"fx";}if(!type||(typeof = type=3D=3D"string"&&!fn))return queue(this[0],type);return = this.each(function(){if(fn.constructor=3D=3DArray)queue(this,type,fn);els= e{queue(this,type).push(fn);if(queue(this,type).length=3D=3D1)fn.call(thi= s);}});},stop:function(clearQueue,gotoEnd){var = timers=3DjQuery.timers;if(clearQueue)this.queue([]);this.each(function(){= for(var = i=3Dtimers.length-1;i>=3D0;i--)if(timers[i].elem=3D=3Dthis){if(gotoEnd)ti= mers[i](true);timers.splice(i,1);}});if(!gotoEnd)this.dequeue();return = this;}});var = queue=3Dfunction(elem,type,array){if(elem){type=3Dtype||"fx";var = q=3DjQuery.data(elem,type+"queue");if(!q||array)q=3DjQuery.data(elem,type= +"queue",jQuery.makeArray(array));}return = q;};jQuery.fn.dequeue=3Dfunction(type){type=3Dtype||"fx";return = this.each(function(){var = q=3Dqueue(this,type);q.shift();if(q.length)q[0].call(this);});};jQuery.ex= tend({speed:function(speed,easing,fn){var = opt=3Dspeed&&speed.constructor=3D=3DObject?speed:{complete:fn||!fn&&easin= g||jQuery.isFunction(speed)&&speed,duration:speed,easing:fn&&easing||easi= ng&&easing.constructor!=3DFunction&&easing};opt.duration=3D(opt.duration&= &opt.duration.constructor=3D=3DNumber?opt.duration:jQuery.fx.speeds[opt.d= uration])||jQuery.fx.speeds.def;opt.old=3Dopt.complete;opt.complete=3Dfun= ction(){if(opt.queue!=3D=3Dfalse)jQuery(this).dequeue();if(jQuery.isFunct= ion(opt.old))opt.old.call(this);};return = opt;},easing:{linear:function(p,n,firstNum,diff){return = firstNum+diff*p;},swing:function(p,n,firstNum,diff){return((-Math.cos(p*M= ath.PI)/2)+0.5)*diff+firstNum;}},timers:[],timerId:null,fx:function(elem,= options,prop){this.options=3Doptions;this.elem=3Delem;this.prop=3Dprop;if= (!options.orig)options.orig=3D{};}});jQuery.fx.prototype=3D{update:functi= on(){if(this.options.step)this.options.step.call(this.elem,this.now,this)= ;(jQuery.fx.step[this.prop]||jQuery.fx.step._default)(this);if(this.prop=3D= =3D"height"||this.prop=3D=3D"width")this.elem.style.display=3D"block";},c= ur:function(force){if(this.elem[this.prop]!=3Dnull&&this.elem.style[this.= prop]=3D=3Dnull)return this.elem[this.prop];var = r=3DparseFloat(jQuery.css(this.elem,this.prop,force));return = r&&r>-10000?r:parseFloat(jQuery.curCSS(this.elem,this.prop))||0;},custom:= function(from,to,unit){this.startTime=3Dnow();this.start=3Dfrom;this.end=3D= to;this.unit=3Dunit||this.unit||"px";this.now=3Dthis.start;this.pos=3Dthi= s.state=3D0;this.update();var self=3Dthis;function t(gotoEnd){return = self.step(gotoEnd);}t.elem=3Dthis.elem;jQuery.timers.push(t);if(jQuery.ti= merId=3D=3Dnull){jQuery.timerId=3DsetInterval(function(){var = timers=3DjQuery.timers;for(var = i=3D0;ithis.options.duration+this.startTime){this.now=3D= this.end;this.pos=3Dthis.state=3D1;this.update();this.options.curAnim[thi= s.prop]=3Dtrue;var done=3Dtrue;for(var i in = this.options.curAnim)if(this.options.curAnim[i]!=3D=3Dtrue)done=3Dfalse;i= f(done){if(this.options.display!=3Dnull){this.elem.style.overflow=3Dthis.= options.overflow;this.elem.style.display=3Dthis.options.display;if(jQuery= .css(this.elem,"display")=3D=3D"none")this.elem.style.display=3D"block";}= if(this.options.hide)this.elem.style.display=3D"none";if(this.options.hid= e||this.options.show)for(var p in = this.options.curAnim)jQuery.attr(this.elem.style,p,this.options.orig[p]);= }if(done)this.options.complete.call(this.elem);return false;}else{var = n=3Dt-this.startTime;this.state=3Dn/this.options.duration;this.pos=3DjQue= ry.easing[this.options.easing||(jQuery.easing.swing?"swing":"linear")](th= is.state,n,0,1,this.options.duration);this.now=3Dthis.start+((this.end-th= is.start)*this.pos);this.update();}return = true;}};jQuery.extend(jQuery.fx,{speeds:{slow:600,fast:200,def:400},step:= {scrollLeft:function(fx){fx.elem.scrollLeft=3Dfx.now;},scrollTop:function= (fx){fx.elem.scrollTop=3Dfx.now;},opacity:function(fx){jQuery.attr(fx.ele= m.style,"opacity",fx.now);},_default:function(fx){fx.elem.style[fx.prop]=3D= fx.now+fx.unit;}}});jQuery.fn.offset=3Dfunction(){var = left=3D0,top=3D0,elem=3Dthis[0],results;if(elem)with(jQuery.browser){var = parent=3Delem.parentNode,offsetChild=3Delem,offsetParent=3Delem.offsetPar= ent,doc=3Delem.ownerDocument,safari2=3Dsafari&&parseInt(version)<522&&!/a= dobeair/i.test(userAgent),css=3DjQuery.curCSS,fixed=3Dcss(elem,"position"= )=3D=3D"fixed";if(elem.getBoundingClientRect){var = box=3Delem.getBoundingClientRect();add(box.left+Math.max(doc.documentElem= ent.scrollLeft,doc.body.scrollLeft),box.top+Math.max(doc.documentElement.= scrollTop,doc.body.scrollTop));add(-doc.documentElement.clientLeft,-doc.d= ocumentElement.clientTop);}else{add(elem.offsetLeft,elem.offsetTop);while= (offsetParent){add(offsetParent.offsetLeft,offsetParent.offsetTop);if(moz= illa&&!/^t(able|d|h)$/i.test(offsetParent.tagName)||safari&&!safari2)bord= er(offsetParent);if(!fixed&&css(offsetParent,"position")=3D=3D"fixed")fix= ed=3Dtrue;offsetChild=3D/^body$/i.test(offsetParent.tagName)?offsetChild:= offsetParent;offsetParent=3DoffsetParent.offsetParent;}while(parent&&pare= nt.tagName&&!/^body|html$/i.test(parent.tagName)){if(!/^inline|table.*$/i= .test(css(parent,"display")))add(-parent.scrollLeft,-parent.scrollTop);if= (mozilla&&css(parent,"overflow")!=3D"visible")border(parent);parent=3Dpar= ent.parentNode;}if((safari2&&(fixed||css(offsetChild,"position")=3D=3D"ab= solute"))||(mozilla&&css(offsetChild,"position")!=3D"absolute"))add(-doc.= body.offsetLeft,-doc.body.offsetTop);if(fixed)add(Math.max(doc.documentEl= ement.scrollLeft,doc.body.scrollLeft),Math.max(doc.documentElement.scroll= Top,doc.body.scrollTop));}results=3D{top:top,left:left};}function = border(elem){add(jQuery.curCSS(elem,"borderLeftWidth",true),jQuery.curCSS= (elem,"borderTopWidth",true));}function = add(l,t){left+=3DparseInt(l,10)||0;top+=3DparseInt(t,10)||0;}return = results;};jQuery.fn.extend({position:function(){var = left=3D0,top=3D0,results;if(this[0]){var = offsetParent=3Dthis.offsetParent(),offset=3Dthis.offset(),parentOffset=3D= /^body|html$/i.test(offsetParent[0].tagName)?{top:0,left:0}:offsetParent.= offset();offset.top-=3Dnum(this,'marginTop');offset.left-=3Dnum(this,'mar= ginLeft');parentOffset.top+=3Dnum(offsetParent,'borderTopWidth');parentOf= fset.left+=3Dnum(offsetParent,'borderLeftWidth');results=3D{top:offset.to= p-parentOffset.top,left:offset.left-parentOffset.left};}return = results;},offsetParent:function(){var = offsetParent=3Dthis[0].offsetParent;while(offsetParent&&(!/^body|html$/i.= test(offsetParent.tagName)&&jQuery.css(offsetParent,'position')=3D=3D'sta= tic'))offsetParent=3DoffsetParent.offsetParent;return = jQuery(offsetParent);}});jQuery.each(['Left','Top'],function(i,name){var = method=3D'scroll'+name;jQuery.fn[method]=3Dfunction(val){if(!this[0])retu= rn;return = val!=3Dundefined?this.each(function(){this=3D=3Dwindow||this=3D=3Ddocumen= t?window.scrollTo(!i?val:jQuery(window).scrollLeft(),i?val:jQuery(window)= .scrollTop()):this[method]=3Dval;}):this[0]=3D=3Dwindow||this[0]=3D=3Ddoc= ument?self[i?'pageYOffset':'pageXOffset']||jQuery.boxModel&&document.docu= mentElement[method]||document.body[method]:this[0][method];};});jQuery.ea= ch(["Height","Width"],function(i,name){var = tl=3Di?"Left":"Top",br=3Di?"Right":"Bottom";jQuery.fn["inner"+name]=3Dfun= ction(){return = this[name.toLowerCase()]()+num(this,"padding"+tl)+num(this,"padding"+br);= };jQuery.fn["outer"+name]=3Dfunction(margin){return = this["inner"+name]()+num(this,"border"+tl+"Width")+num(this,"border"+br+"= Width")+(margin?num(this,"margin"+tl)+num(this,"margin"+br):0);};});})(); ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/genlink.js function get_link(a, b) {=0A= document.write("" + b = + "");=0A= }=0A= =0A= function get_pdf_link(a, b, c) {=0A= document.writeln('' + b + = ' (Size: ' + c + 'K)');=0A= }=0A= =0A= function get_button_link(cgi, params, imgbutton) {=0A= document.writeln('

3D"Click

');=0A= }=0A= =0A= function get_text_link(url, linktext)=0A= {=0A= document.writeln('' + = linktext + '');=0A= }=0A= =0A= function get_htmlftext_link(a, b) {=0A= document.writeln("" + = b + ", ");=0A= }=0A= =0A= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/personalisation.js /*=0A= * Project : Interscience Redesign=0A= * File : personalisation.js=0A= * Creation Date : 25th March 2003=0A= * Author : Jonathan Sugar=0A= *=0A= * Various functions to deliver personalisation functionality.=0A= */=0A= =0A= // Pre-declare userName so it's available when we need to test if the = page=0A= // assembler ran OK=0A= var userName =3D null;=0A= var shcrtCookie =3D null;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Factory Methods=0A= =0A= // Simple wraper object to encapsulate the data for a co-branding item.=0A= function coBrandingItem(image, imageAltText, href)=0A= {=0A= //alert("Making new coBrandingItem:\nImage: " + image + = "\nimageAltText" + imageAltText + "\nhref: " + href);=0A= this.image =3D image;=0A= this.imageAltText =3D imageAltText;=0A= this.href =3D href;=0A= }=0A= =0A= /*=0A= * Insert the 'Customer co-branding' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert customer co branding. Loop through 'customerCoBranding' array=0A= * inserting XHTML where needed.=0A= *=0A= * NOTE: the array contains ONLY the resource location (the location of a = gif=0A= * on the file system), the required XHTML is then added where needed. = This way=0A= * we maintain the seperation between presentation and content.=0A= */=0A= function insertCustomerCoBranding(maxBranding)=0A= {=0A= if( customerCoBranding[0].image !=3D "none")=0A= {=0A= document.writeln('

');=0A= document.writeln('

');=0A= document.writeln('

' + imageAltText + '
' + imageAltText + = '
More Providers

');=0A= document.writeln('

');=0A= document.writeln('

3D""

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the 'My Area' section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= *=0A= * My profile link absolute as this file isnt only run from w3 anymore.=0A= */=0A= function insertMyArea(userdata)=0A= {=0A= // just in case the page assembler isn't running.=0A= =0A= =0A= if (userName !=3D null)=0A= {=0A= document.writeln("

" + = userName.substring(0,33) + "..., access your
" + userName + = ", access your

My Profile"); =0A= } =0A= document.writeln(getLoginOutLink());=0A= //CR 3652 getAthenStatus() as added=0A= document.writeln(getAthenStatus());=0A= document.writeln("

");=0A= } else {=0A= if(typeof(environment)!=3D'undefined' && = environment=3D=3D'PRODUCTION') {=0A= document.writeln("

Log Out");=0A= document.writeln("

"); =0A= }=0A= }=0A= if (menuloadedflag){=0A= wisMenu();=0A= }=0A= }=0A= =0A= /*=0A= * Insert the Customer Admin 'Login/Logout' link=0A= * -----------------------------=0A= *=0A= * Author: Bobby Jack, December 2004.=0A= *=0A= */=0A= function insertAdminLink(page)=0A= {=0A= val =3D getCookie("AID");=0A= =0A= if (val && val !=3D "-1")=0A= {=0A= document.writeln('

Logout');=0A= }=0A= else=0A= {=0A= document.writeln('

');=0A= }=0A= }=0A= =0A= /*=0A= * Insert the username section.=0A= * -----------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= *=0A= * 1. Insert the username.=0A= */=0A= function insertUserName()=0A= {=0A= document.write(userName);=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the login/logout cgi=0A= * ---------------------------------------------------=0A= *=0A= * Author: Jonathan Sugar, March 2003.=0A= * Updated: Ben Marvell, April 2006=0A= * Had to change the links absolute as this file isnt only run from w3 = anymore.=0A= */=0A= function getLoginOutLink()=0A= {=0A= if(userName !=3D "")=0A= {=0A= return "

";=0A= }else=0A= {=0A= return "

";=0A= }=0A= }=0A= =0A= /*=0A= * Return the appropriate link to the shopping cart content page=0A= * ---------------------------------------------------=0A= *=0A= * Author: Zhiming & Warrell June 2007=0A= */=0A= function getShCrtLink(logged)=0A= {=0A= if(logged =3D=3D true )=0A= return "

";=0A= else=0A= return "

";=0A= }=0A= =0A= function toggleShCrtLink()=0A= {=0A= shcrtCookie =3D readCookie("SHCRT");=0A= if(shcrtCookie !=3D null)=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "block";=0A= }=0A= }=0A= else=0A= {=0A= if(document.all)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= document.getElementById("shcrt_id").style.display =3D "none";=0A= }=0A= }=0A= }=0A= =0A= =0A= =0A= function readCookie(name)=0A= {=0A= var nameEQ =3D name + "=3D";=0A= var ca =3D document.cookie.split(';');=0A= for(var i=3D0; iYou are logged in = to Athens';=0A= }=0A= else=0A= {=0A= return "

";=0A= }=0A= =0A= } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/site.js /************************************************************************= ***************************=0A= FILE: site.js=0A= AUTHOR: Jonathan Sugar, Chris Neatby-Smith and Digital Pulp. July = 2003.=0A= =0A= DESCRIPTION: Javascript relating to site wide functionality across =0A= InterScience.=0A= =0A= INCLUDES FUNCTIONS=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Search Functions=0A= ----------------=0A= =0A= selectAndSubmit() - for deciding where to submit a query based on the = state of the form.=0A= processallContentSearch() - for validating form input for an all = content search.=0A= processTitleSearch() - for validating form input for a Title search.=0A= checkCitationSearch() - for validating the citation search form.=0A= selectAll() - check all the checkboxes in a form.=0A= do_popup() - stasa Acronym Finder window popup function.=0A= =0A= =0A= Other Functions=0A= ---------------=0A= =0A= fixInlineLists() - fix netscape 4.x bug where

tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract | References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if ((isNaN(parseInt(itemID))=3D=3Dtrue)||(arguments.length >=3D 4 && = arguments[3] =3D=3D 'cluster'))=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= //check whether the last 2 arguments is used for urllink.=0A= // urllink is needed to open up mail form for mrw pages on tomcat = port=0A= if (arguments.length>=3D5 && = arguments[arguments.length-2]=3D=3D'urllink' && = arguments[arguments.length-1]!=3D'')=0A= {=0A= url =3D arguments[arguments.length-1] + url;=0A= }=0A= =0A= if (arguments.length>=3D5 && arguments[3]=3D=3D'currentlink' && = arguments[4]!=3D'')=0A= {=0A= url =3D url + '¤tLink=3D' + arguments[4];=0A= =0A= //processing specific cases=0A= if (arguments[4]=3D=3D'jcatalogjsphdr')=0A= {=0A= //get the issn and pass it the next stage for processing=0A= var currloc =3D location.href;=0A= var issnloc =3D currloc.indexOf("&issn=3D");=0A= if (issnloc !=3D -1)=0A= {=0A= url =3D url + '¤tISSN=3D' + = currloc.substring(issnloc+6);=0A= }=0A= }=0A= // issn is needed for cocoon rendered mrw to form the final url.=0A= else if ( (arguments[4]=3D=3D'cocoonmrwhome') || = (arguments[4]=3D=3D'cocoonmrwarticle') )=0A= {=0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'issn' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tISSN=3D' + arguments[6];=0A= }=0A= //getting the parameters of the currently shown mrw from the = url=0A= //the method used here is a little crude, it extracts the = values from the current url of the page the user is in =0A= //to pass it to the background program to reconstruct the = requred url=0A= if (arguments[4]=3D=3D'cocoonmrwhome')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= var mrwFileParam =3D mrwParamArr[6];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= mrwFileParam =3D = mrwFileParam.substring(0,seploc);=0A= }=0A= seploc =3D mrwFileParam.indexOf("?");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwUrlParam=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= =0A= }=0A= else if (arguments[4]=3D=3D'cocoonmrwarticle')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= url =3D url + '&mrwAid=3D' + mrwParamArr[7];=0A= url =3D url + '&mrwVersion=3D' + mrwParamArr[8];=0A= var mrwFileParam =3D mrwParamArr[9];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= }=0A= }=0A= }=0A= =0A= //checking if a html file exists in the url=0A= var tmpfname =3D location.href;=0A= var loc =3D tmpfname.indexOf("?");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(0,loc);=0A= }=0A= loc =3D tmpfname.indexOf(".html");=0A= if (loc !=3D -1)=0A= {=0A= loc =3D tmpfname.lastIndexOf("/");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(loc+1);=0A= url =3D url + '¤tFile=3D' + tmpfname;=0A= }=0A= }=0A= =0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'currentyear' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tYear=3D' + arguments[6];=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln(' 3D"blank"

');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln(' 3D"blank"

'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x" + = liels[j].innerHTML + "

You do not have = anything saved in this menu.

";=0A= else=0A= tmpinnerhtml +=3D "

" = + liels[j].innerHTML + "

"; =0A= } =0A= } else {=0A= //setup var to see if more is required=0A= var more =3D (subnodeslength < lilength) ? true : = false; =0A= var flag =3D true;=0A= for (var j=3D0; j" + liels[j].innerHTML + = "";=0A= } else if (j > lilength-3){=0A= if (j =3D=3D lilength-2){=0A= var url =3D liels[j].innerHTML.split('"')[1];=0A= tmpinnerhtml +=3D "

" + liels[j].innerHTML + "

";=0A= } else {=0A= tmpinnerhtml +=3D "

" + liels[j].innerHTML + = "

"; =0A= } =0A= } =0A= }=0A= // set last two menu items to have no rollover and = a border at the top =0A= }=0A= menu.childNodes[x].childNodes[y].innerHTML =3D = tmpinnerhtml;=0A= // set default menu elements with diff style=0A= if (flag){=0A= if (more){=0A= liels[liels.length-3].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-3].className =3D "noroll";=0A= liels[liels.length-2].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-2].className =3D "noroll";=0A= liels[liels.length-1].className =3D "noroll";=0A= more =3D false;=0A= } else {=0A= liels[liels.length-2].style.borderTop =3D "1px solid = #DDDDDD";=0A= liels[liels.length-2].className =3D "noroll";=0A= liels[liels.length-1].className =3D "noroll";=0A= } =0A= flag =3D false; =0A= } =0A= =0A= // set sub menu title for the msnu=0A= liels[0].className =3D "hoverTitle";=0A= // apply rollover functions to hide/show sub menus=0A= if (classname =3D=3D "menuDOM"){=0A= menu.childNodes[x].onmouseover =3D function(){=0A= // safari doesnt handle auto in absoulte = positioning correctly so this code makes the menus display correctly.=0A= if (navigator.userAgent.indexOf("Safari") !=3D -1){=0A= if(!window.devicePixelRatio) {=0A= this.getElementsByTagName("UL")[0].style.marginTop =3D "20px";=0A= this.getElementsByTagName("UL")[0].style.marginLeft =3D "0";=0A= }=0A= }=0A= this.className =3D"menuhover domArrowOver";=0A= if(document.all) = this.getElementsByTagName("iframe")[0].style.height=3Dthis.getElementsByT= agName("ul")[0].offsetHeight;=0A= }=0A= menu.childNodes[x].onmouseout=3Dfunction() {=0A= this.className =3D "domArrowOut";=0A= }=0A= }=0A= =0A= if(document.all) {=0A= var newIframe =3D document.createElement("iframe");=0A= newIframe.style.filter =3D = "progid:DXImageTransform.Microsoft.Alpha(style=3D0,opacity=3D0)";=0A= menu.childNodes[x].appendChild(newIframe);=0A= }=0A= =0A= } =0A= }=0A= // deletes the sub menus on the IEMAC as they have a = background bug, will still remain on NS6=0A= if ((navigator.userAgent.indexOf("Mac") !=3D -1) && = (navigator.userAgent.indexOf("MSIE") !=3D -1)){=0A= menu.childNodes[x].innerHTML =3D = menu.childNodes[x].innerHTML.split(""=0A= var menu =3D document.all["menu"].children[0];=0A= menu.style.marginBottom =3D "-3px";=0A= for (var x=3D1; x" + tmp + "";=0A= } else if (x=3D=3D5 || x=3D=3D6){ =0A= tmptable +=3D "" + tmp + = "";=0A= } else {=0A= tmptable +=3D "" + tmp + = "";=0A= }=0A= if (x =3D=3D (menu.children.length-1)){=0A= tmptable +=3D ""; =0A= }=0A= } else {=0A= var tmp =3D menu.children[x].innerHTML.split("" + tmp + = "";=0A= } else if (x=3D=3D2) {=0A= tmptable +=3D "" + tmp + = "";=0A= }=0A= }=0A= }=0A= menu.innerHTML =3D tmptable;=0A= }=0A= };=0A= =0A= var menuloadedflag =3D true;=0A= =0A= =0A= var time =3D new Date();=0A= //@@@DM It was anoying me this error =0A= var ordval=3D (time.getTime());=0A= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/js/journalhome.js //=0A= // Homepage links format:=0A= // homepagelinks[i][0] =3D location=0A= // homepagelinks[i][1] =3D currenthref=0A= // homepagelinks[i][2] =3D type: "e" =3D end of line, "s" =3D separator, = "" =3D normal=0A= //=0A= var writeLinksTraceOn =3D false;=0A= function writeJournalLinks(filename, oid)=0A= {=0A= var url =3D new String(document.location);=0A= var urlpathinfo =3D "";=0A= var pathinfomatch =3D false;=0A= =0A= // Find the pathinfo in the URL - need it later (probably)=0A= //=0A= // Both url and currenthref are expected to be of the form:=0A= // .....//[/]=0A= //=0A= =0A= urlindex =3D url.indexOf("jabout");=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("mrwhome");=0A= }=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("collectionhome");=0A= }=0A= if (urlindex =3D=3D -1)=0A= {=0A= urlindex =3D url.indexOf("bookhome");=0A= }=0A= =0A= if (urlindex !=3D -1) // If found a known CGI name....=0A= {=0A= // We needs a pathinfo match.....=0A= pathinfomatch =3D true;=0A= =0A= // Find the end of the cgi-name=0A= urlindex =3D url.indexOf("/", urlindex + 1);=0A= =0A= // Look for the start of pathinfo=0A= urlindex =3D url.indexOf("/", urlindex + 1);=0A= =0A= if (urlindex !=3D -1)=0A= {=0A= urlindex1 =3D url.indexOf("?", urlindex + 1);=0A= =0A= if(urlindex1 !=3D -1){=0A= urlpathinfo =3D url.substring(urlindex + 1, urlindex1);=0A= writeLinksTrace("urlpathinfo: " + urlpathinfo); =0A= }else{ =0A= urlpathinfo =3D url.substring(urlindex + 1, url.length);=0A= writeLinksTrace("urlpathinfo: " + urlpathinfo);=0A= }=0A= }=0A= }=0A= =0A= var colnum =3D 0;=0A= =0A= for (var i =3D 0; i < homepagelinks.length; i++)=0A= {=0A= var location =3D homepagelinks[i][0];=0A= var currenthref =3D homepagelinks[i][1];=0A= var type =3D homepagelinks[i][2];=0A= =0A= writeLinksTrace(location + " : " + currenthref + " : " + type);=0A= =0A= if(type =3D=3D "x") // End of the list=0A= {=0A= break;=0A= }=0A= if(type =3D=3D "s")=0A= {=0A= document.writeln('
');=0A= colnum =3D 0;=0A= continue;=0A= }=0A= if (colnum > 0)=0A= {=0A= document.writeln(' | ');=0A= }=0A= =0A= var hrefindex;=0A= var urlindex;=0A= var greydisplay =3D false;=0A= =0A= // See what type of link we have=0A= =0A= // Cases here are for URLs with no /relevant/ pathinfo=0A= if (pathinfomatch !=3D true)=0A= {=0A= hrefindex =3D currenthref.indexOf("jhome");=0A= if (hrefindex !=3D -1)=0A= {=0A= urlindex =3D url.indexOf("jhome");=0A= if (urlindex !=3D -1)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= if (hrefindex =3D=3D -1) // Didn't find jhome, try jtoc=0A= {=0A= hrefindex =3D currenthref.indexOf("jtoc");=0A= if (hrefindex !=3D -1)=0A= {=0A= urlindex =3D url.indexOf("jtoc");=0A= if (urlindex !=3D -1)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= }=0A= // Add more non-pathinfo cases here...=0A= }=0A= =0A= // Cases under here are for cases with relevant pathinfo=0A= if (pathinfomatch =3D=3D true)=0A= {=0A= var hrefmatch =3D false;=0A= var hrefpathinfo =3D "";=0A= =0A= writeLinksTrace("pathinfo handler");=0A= =0A= // Find the pathinfo in the href=0A= =0A= hrefindex =3D currenthref.indexOf("jabout");=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("mrwhome");=0A= }=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("collectionhome");=0A= }=0A= if (hrefindex =3D=3D -1)=0A= {=0A= hrefindex =3D currenthref.indexOf("bookhome");=0A= }=0A= if (hrefindex !=3D -1)=0A= {=0A= // We needs a pathinfo match.....=0A= hrefmatch =3D true;=0A= =0A= // Find the end of the cgi-name=0A= hrefindex =3D currenthref.indexOf("/", hrefindex + 1);=0A= =0A= // Look for the start of pathinfo=0A= hrefindex =3D currenthref.indexOf("/", hrefindex + 1);=0A= =0A= if (hrefindex !=3D -1)=0A= {=0A= hrefpathinfo =3D currenthref.substring(hrefindex + 1, = currenthref.length);=0A= writeLinksTrace("hrefpathinfo: " + hrefpathinfo);=0A= }=0A= }=0A= =0A= // If we found a CGI matches in currenthref, and the=0A= // pathinfos match then grey this link=0A= if (hrefmatch =3D=3D true && urlpathinfo =3D=3D hrefpathinfo)=0A= {=0A= greydisplay =3D true;=0A= }=0A= }=0A= =0A= // Time to write the link=0A= if (greydisplay =3D=3D true)=0A= {=0A= document.writeln('' + location + '');=0A= }=0A= else=0A= {=0A= document.writeln('' + = location + '');=0A= }=0A= =0A= // Defunct - separators now worked by from colnum=0A= // If end of line skip separator=0A= //if(type !=3D "e")=0A= //{=0A= // document.writeln(' | ');=0A= //}=0A= =0A= colnum++;=0A= }=0A= }=0A= =0A= function writeLinksTrace(message)=0A= {=0A= if (writeLinksTraceOn)=0A= {=0A= document.writeln(message);=0A= }=0A= }=0A= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/FILE?TPL=journal-article.html-navbar&mode=html Navbar


	Home / Medical, Veterinary and Health Sciences / = Pathology and Laboratory Medicine=20

3D"Utility

3D""=20

------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/txt.jump-to.gif R0lGODlhOQAQAKIHAP/x3P/WmP+8V/+yP//lv//Mf/+ZAP///yH5BAEAAAcALAAAAAA5ABAAAAPM eLrc/jAyIE8xihiiTMkGpgiecoUCt5xhyJHGQEEXqJaHZszhZ3mnWa5wIgIChoBGEKnlNh2fZhA4 AGI+p6baGAwWXpOIIBTboqACs+DNjqHdb4d5QAKuvtX7Jt1gBmxuXjFlCmFoTxyFP2cHOBqOGgCA YgMCAYsHh450GiorVVpwj38Df24Vm4dODISmCldMSCqQSEyUjBKbF2QxJjNIPQswBnRPVkmaqLpy VqYhFHgLAGQN1JkV2Q0E1bDa3+Dh4uPk5ebn6Onq698JADs= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #333; PADDING-TOP: 0px; BACKGROUND-COLOR: #fff } H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DT { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .txt { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } FIELDSET { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; BORDER-TOP-STYLE: none! = important; PADDING-TOP: 0px! important; BORDER-RIGHT-STYLE: none! = important; BORDER-LEFT-STYLE: none! important; BORDER-BOTTOM-STYLE: = none! important } LEGEND { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.25em 0px 0.25em 1.25em; PADDING-TOP: 0px } DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .homepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .homepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .homepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .HomepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .HomepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .HomepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .HomepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } .HomepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } TABLE.menuIEFOUR { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; MARGIN: 0px; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURSIDE { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } TABLE.menuIEFOUR TD { FONT-WEIGHT: bold; FONT-SIZE: 70%; PADDING-BOTTOM: 0.2em; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; FONT-WEIGHT: normal; COLOR: white; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { FONT-WEIGHT: bold; FONT-SIZE: 0.7em; TEXT-TRANSFORM: uppercase; COLOR: = #6089b2; FONT-STYLE: normal } H3.navigationHeader EM { FONT-SIZE: 1.1em; COLOR: #ff9b06; FONT-STYLE: normal } .homepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .HomepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .homepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .HomepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } DIV.banner TABLE TD A { DISPLAY: block } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-REPEAT: repeat-y; BACKGROUND-COLOR: #13709d } UL.menuDOM LI { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: none; PADDING-BOTTOM: = 0.2em; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; BACKGROUND: white; = PADDING-BOTTOM: 0px; COLOR: white; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM LI UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuIEMAC { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM A { PADDING-RIGHT: 0.1em; DISPLAY: block; PADDING-LEFT: 0.1em; FONT-WEIGHT: = bold; PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } .hideNSFOUR LI A { WHITE-SPACE: normal } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } LI.nosaved EM { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuDOM LI UL { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover UL { BORDER-RIGHT: #90d7ff 1px solid; BORDER-TOP: #90d7ff 1px solid; = DISPLAY: block; Z-INDEX: 999; BACKGROUND: white; LEFT: auto; = MARGIN-LEFT: -1.25em; BORDER-LEFT: #90d7ff 1px solid; WIDTH: 200px; = BORDER-BOTTOM: #90d7ff 1px solid; TOP: auto; voice-family: inherit } UL.menuDOM LI IFRAME { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover IFRAME { Z-INDEX: 998; LEFT: auto; MARGIN-LEFT: -1.25em; WIDTH: 202px; TOP: auto } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-RIGHT: 5px; MARGIN-TOP: 0px! important; DISPLAY: block; = PADDING-LEFT: 5px; FONT-WEIGHT: bold; BACKGROUND: #ff9900; = PADDING-BOTTOM: 5px; WIDTH: 190px; COLOR: white! important; PADDING-TOP: = 5px; voice-family: inherit } LI.nosaved EM { FONT-WEIGHT: normal! important; COLOR: black! important; = TEXT-DECORATION: none! important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none! important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } .domArrowOut { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { DISPLAY: inline; PADDING-BOTTOM: 3px } UL.menuIEMAC LI UL { LEFT: -999em; POSITION: absolute } UL.menuIEMAC { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif)!= important; PADDING-BOTTOM: 0.1em; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } #user { PADDING-RIGHT: 2em; PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: = white } #mycart { PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: white } #menu { BORDER-RIGHT: transparent 1px solid; BORDER-TOP: transparent 1px solid; = BORDER-LEFT: transparent 1px solid; BORDER-BOTTOM: transparent 1px solid } .hideNSFOUR LI A { WHITE-SPACE: normal } .hideNSFOUR LI { WHITE-SPACE: normal } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.standards.css @import url( = http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { PADDING-LEFT: 1em; MARGIN: 0.25em 0em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-POSITION: 100% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.basic.gif); = BACKGROUND-REPEAT: no-repeat } #searchBox { BACKGROUND-POSITION: 0% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.search.gif); = BACKGROUND-REPEAT: no-repeat } #citationBox { BACKGROUND-POSITION: 0% 0%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.citation-finder.gif)= ; BACKGROUND-REPEAT: no-repeat } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { FONT-WEIGHT: bold; MARGIN: 0px; TEXT-ALIGN: right } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { COLOR: #f90; BORDER-BOTTOM: #ccc 2px solid } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { FONT-WEIGHT: normal; TEXT-ALIGN: left } #contentFrame .mainCol #footer { BORDER-TOP: #ccc 2px solid; MARGIN: 10px 10px 0px; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 7px; MARGIN: = 0px 0px 15px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 0px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px; BORDER-LEFT-STYLE: none } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { MARGIN-TOP: 1px; BORDER-BOTTOM: #cce5ff 1px solid } #contentFrame .sideCol #citationBox .item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 0px 10px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .sideCol #relatedProducts UL { MARGIN-TOP: 0px; PADDING-BOTTOM: 8px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { PADDING-RIGHT: 0.5em; TEXT-ALIGN: right } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { FONT-WEIGHT: bold; COLOR: #9cf; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= WIDTH: 100%; BACKGROUND-REPEAT: repeat-y } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; WHITE-SPACE: nowrap } #personalnavSpecial { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0.5em; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-RIGHT: #069 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: #069 2px = solid; PADDING-LEFT: 2px; FONT-SIZE: 11pt; PADDING-BOTTOM: 2px; = BORDER-LEFT: #069 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #069 2px = solid; FONT-FAMILY: arial } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { LINE-HEIGHT: 140%; TEXT-ALIGN: center } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.home.jpg); = BACKGROUND-REPEAT: no-repeat; BACKGROUND-COLOR: #001941 } #logoCell { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.jpg); = BACKGROUND-REPEAT: no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; FONT-WEIGHT: bold; COLOR: #666 } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; BORDER-LEFT: = red 1px solid; BORDER-BOTTOM: red 1px solid; BACKGROUND-COLOR: #fcc } #browserWarning { BORDER-RIGHT: #c00 1px solid; PADDING-RIGHT: 0.3em; BORDER-TOP: #c00 = 1px solid; PADDING-LEFT: 0.3em; FONT-SIZE: 100%; PADDING-BOTTOM: 0.3em; = MARGIN: 5px 28px; BORDER-LEFT: #c00 1px solid; COLOR: #300; PADDING-TOP: = 0.3em; BORDER-BOTTOM: #c00 1px solid; FONT-FAMILY: arial; = BACKGROUND-COLOR: #fef } .invisible { OVERFLOW: hidden; WIDTH: 0px; POSITION: absolute; HEIGHT: 0px } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { FLOAT: left; MARGIN: 10px } .linkPrint { FLOAT: right; MARGIN: 10px 20px 0px 0px } .linkTop { CLEAR: both; TEXT-ALIGN: right } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { FONT-WEIGHT: bold; COLOR: #c00 } #errorList LI { FONT-WEIGHT: bold; COLOR: #c00! important; LIST-STYLE-TYPE: none } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #contentFrame #intro .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; PADDING-BOTTOM: 6px; MARGIN: = 10px 0px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { PADDING-LEFT: 2em; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -2em } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 8px; COLOR: #000; LINE-HEIGHT: = 150%; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalReferences .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { MARGIN: 0px; TEXT-ALIGN: center } #contentFrame #content .issueNav SPAN { FONT-WEIGHT: bold; COLOR: #f90 } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px 0.5em; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #ccc 1px solid } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-LEFT: 6px; PADDING-BOTTOM: 10px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none! important } .journalArticleMain #intro .item { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px! important } .journalArticleMain #searchBox { BORDER-RIGHT: #99c2d6 1px solid; WIDTH: 150px } .journalArticleMain #intro #searchBox .item { PADDING-RIGHT: 10px! important; PADDING-LEFT: 10px! important; = PADDING-BOTTOM: 10px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #565565; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #content .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content .prerendered TABLE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TH { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT A { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT[size=3D'+1'] { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #666 } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-WEIGHT: bold; FONT-SIZE: 14px } #contentFrame #content .prerendered FONT[size=3D'4'] A { FONT-SIZE: 14px; COLOR: #090 } #contentFrame #content .prerendered P { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; TEXT-TRANSFORM: = uppercase; COLOR: #f90 } .prerendered .firstLevelHeading { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .secondLevelHeading { DISPLAY: block; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { FONT-SIZE: 10pt; COLOR: #369 } .prerendered .referenceNum { FONT-SIZE: 10pt; COLOR: #369 } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/bpg.css .prerendered .invisible-anchor { DISPLAY: none } .prerendered A { COLOR: #336699; TEXT-DECORATION: none } .prerendered .body-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .appendix-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .toc-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .article { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .doi-title { MARGIN-BOTTOM: 6pt } .prerendered .articletext { MARGIN-TOP: 12pt; FONT-WEIGHT: bold; FONT-SIZE: 12px; MARGIN-BOTTOM: = 0.4em; TEXT-TRANSFORM: uppercase; COLOR: #333333 } .prerendered P.para { MARGIN-TOP: 0em } .prerendered .titlegroup { MARGIN-BOTTOM: 12pt } .prerendered .title-document { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .title-surtitle { FONT-WEIGHT: bold; FONT-SIZE: 100%; COLOR: #666666 } .prerendered .title-subtitle { FONT-WEIGHT: bold; FONT-SIZE: 100%; COLOR: #666666 } .prerendered .correspondence-label { =09 } .prerendered P.reference-list-para { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: middle; LINE-HEIGHT: 150%; PADDING-TOP: 0px } .prerendered .clear-both { CLEAR: both; LINE-HEIGHT: 0px; HEIGHT: 0px } .prerendered UL.references-list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.references-list { CLEAR: both } .prerendered UL.references-list LI { CLEAR: both } .prerendered UL.references-list SPAN.reference-list-label { FLOAT: left; WIDTH: 3% } .prerendered UL.references-list P.reference-list-para { FLOAT: left; MARGIN: 0px; WIDTH: 97% } .prerendered UL.toc-list LI { FONT-SIZE: 100% } .prerendered UL.references-list LI { FONT-SIZE: 100% } .prerendered UL.listlevel1 LI { FONT-SIZE: 100%; LINE-HEIGHT: 120% } .prerendered UL.listlevel2 LI { FONT-SIZE: 100% } .prerendered UL.listlevel3 LI { FONT-SIZE: 100% } .prerendered UL.listlevel4 LI { FONT-SIZE: 100% } .prerendered UL.listlevel5 LI { FONT-SIZE: 100% } .prerendered UL.listlevel6 LI { FONT-SIZE: 100% } .prerendered UL LI { FONT-SIZE: 100% } .prerendered P.list-para { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px } .prerendered UL.listlevel1 { MARGIN-BOTTOM: 12pt } .prerendered UL.listlevel1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel1 { CLEAR: both } .prerendered UL.listlevel2 { CLEAR: both } .prerendered UL.listlevel3 { CLEAR: both } .prerendered UL.listlevel4 { CLEAR: both } .prerendered UL.listlevel5 { CLEAR: both } .prerendered UL.listlevel6 { CLEAR: both } .prerendered UL.listlevel1 LI { CLEAR: both } .prerendered UL.listlevel2 LI { CLEAR: both } .prerendered UL.listlevel3 LI { CLEAR: both } .prerendered UL.listlevel4 LI { CLEAR: both } .prerendered UL.listlevel5 LI { CLEAR: both } .prerendered UL.listlevel6 LI { CLEAR: both } .prerendered UL.listlevel1 SPAN.list-label { FLOAT: left; WIDTH: 5%; LINE-HEIGHT: 150% } .prerendered UL.listlevel1 P.list-para { FLOAT: left; MARGIN: 0px; WIDTH: 95%; LINE-HEIGHT: 150% } .prerendered UL.listlevel2 { CLEAR: both; MARGIN: 0px 0px 10px 5% } .prerendered UL.listlevel2 { CLEAR: both; MARGIN: 0px 0px 10px 5% } .prerendered UL.listlevel3 { MARGIN: 0px 0px 20px 5% } .prerendered UL.listlevel3 SPAN.list-label { FLOAT: left; WIDTH: 5% } .prerendered UL.listlevel3 P.list-para { FLOAT: left; WIDTH: 95% } .prerendered UL.listlevel4 { CLEAR: both; MARGIN: 0px 0px 30px 5% } .prerendered UL.listlevel5 { MARGIN: 0px 0px 40px 5% } .prerendered UL.listlevel6 { MARGIN: 0px 0px 50px 5% } .prerendered UL.listlevel2 SPAN.list-label { FLOAT: left; WIDTH: 5% } .prerendered UL.listlevel2 P.list-para { FLOAT: left; WIDTH: 95% } .prerendered .table { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt; TEXT-ALIGN: center } .prerendered .table-title { FONT-WEIGHT: bold } .prerendered H1 { MARGIN-TOP: 12pt; FONT-WEIGHT: bold; FONT-SIZE: 1.1em; MARGIN-BOTTOM: = 0.4em; COLOR: #336699 } .prerendered H1 .abstract-title { MARGIN-TOP: 0pt; FONT-WEIGHT: bold; FONT-SIZE: 1.1em; MARGIN-BOTTOM: = 0.4em } .prerendered H1 .abstract-title-with-preceding-heading { MARGIN-TOP: 0pt; FONT-WEIGHT: bold; FONT-SIZE: 1.1em; MARGIN-BOTTOM: = 0.4em } .prerendered H2 { MARGIN-TOP: 0.4em; FONT-WEIGHT: bold; FONT-SIZE: 1em; MARGIN-BOTTOM: = 0em; COLOR: #336699 } .prerendered H3 { MARGIN-TOP: 0pt; FONT-WEIGHT: bold; FONT-SIZE: 1em; MARGIN-BOTTOM: = 0.4em; COLOR: #336699; FONT-STYLE: italic } .prerendered .h3-inline { FONT-WEIGHT: bold; FONT-SIZE: 1em; COLOR: #336699; FONT-STYLE: italic } .prerendered H4 { MARGIN-TOP: 0pt; FONT-SIZE: 1em; MARGIN-BOTTOM: 0.4em; COLOR: #336699; = FONT-STYLE: italic } .prerendered .h4-inline { FONT-SIZE: 1em; COLOR: #336699; FONT-STYLE: italic } .prerendered H5 { MARGIN-TOP: 0pt; FONT-SIZE: 1em; MARGIN-BOTTOM: 0.4em } .prerendered .h5-inline { DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 1em; FONT-STYLE: normal } .prerendered .heading5-inline { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; COLOR: #666666 } .prerendered .correspondence-address { MARGIN-TOP: 8pt; DISPLAY: block } .prerendered .bpg40copyright { MARGIN-TOP: 16pt; DISPLAY: none } .prerendered .doi-block { MARGIN-TOP: 16pt; DISPLAY: block; MARGIN-BOTTOM: 8pt } .prerendered .doi-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .keywords-block { MARGIN-TOP: 16pt; DISPLAY: block } .prerendered .keyword-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .abstract-content { CLEAR: left; DISPLAY: block; PADDING-TOP: 1pt } .prerendered .b { FONT-WEIGHT: bold } .prerendered .highlight { FONT-WEIGHT: bold } .prerendered .i { FONT-STYLE: italic } .prerendered .overline { TEXT-DECORATION: overline } .prerendered .slanted { FONT-STYLE: oblique } .prerendered .smallcapitals { FONT-VARIANT: small-caps } .prerendered .strike { TEXT-DECORATION: line-through } .prerendered .tt { FONT-FAMILY: "Courier","Lucida Sans Typewriter","Courier = New","LucidaTypewriter", fixed } .prerendered .u { TEXT-DECORATION: underline } .prerendered .uu { TEXT-DECORATION: underline } .prerendered .openface { =09 } .prerendered .roman { FONT-STYLE: normal } .prerendered .sansserif { FONT-FAMILY: sans-serif } .prerendered .scriptface { =09 } .prerendered .questiongroup { =09 } .prerendered .question { =09 } .prerendered .answer { =09 } .prerendered .hint { =09 } .prerendered .feedback { =09 } .prerendered .toc-content { =09 } .prerendered .toc-journal-title { FONT-WEIGHT: bold } .prerendered .toc-issn { =09 } .prerendered .toc-vol-issue { MARGIN-TOP: 12pt } .prerendered .toc-pages { =09 } .prerendered .toc-sections { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt } .prerendered .toc-tables { =09 } .prerendered .toc-figures { =09 } .prerendered .toc-abstract-only { =09 } .prerendered .block_formula { DISPLAY: block; MARGIN: 1em 0pt; WIDTH: 98%; WHITE-SPACE: nowrap; = POSITION: relative } .prerendered .block_formula .formula_caption { RIGHT: 0px; POSITION: absolute; TOP: 33% } .prerendered .block_formula .formula_display { =09 } .prerendered .inline_formula IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .reference-document-title { =09 } .prerendered .reference-subtitle-title { =09 } .prerendered .reference-journal-title { FONT-STYLE: italic } .prerendered .reference-book-title { FONT-STYLE: italic } .prerendered .reference-conference-title { =09 } .prerendered .reference-other-title { =09 } .prerendered .reference-date { =09 } .prerendered .reference-volume { FONT-WEIGHT: bold } .prerendered .reference-page { =09 } .prerendered .reference-publisher { =09 } .prerendered .reference-edition { =09 } .prerendered .reference-issue { =09 } .prerendered .reference-thesis { =09 } .prerendered .reference-inpress { =09 } .prerendered .reference-supplement { =09 } .prerendered .reference-miscellaneoustext { =09 } .prerendered .figure-legend { FONT-WEIGHT: bold; FONT-SIZE: 0.8em } .prerendered P.legend-para { MARGIN-TOP: 0em; MARGIN-BOTTOM: 0em; MARGIN-LEFT: 1.6em } .prerendered .figure { MARGIN-BOTTOM: 6pt } .prerendered .image-links { FONT-SIZE: 0.8em; MARGIN-LEFT: 2em } .prerendered .table-legend { =09 } .prerendered .toc-content { =09 } .prerendered TABLE.data-table TH { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .prerendered TABLE.data-table TD { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .prerendered .bp_abstractinfo { DISPLAY: none } .prerendered .header-footnotes { MARGIN-TOP: 6pt } .prerendered .inline_image IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .fixed-image { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered .fixed-legend { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered A.externallink { COLOR: #336699 } .prerendered .subsection-box { BACKGROUND-COLOR: #f9e3df } .prerendered .tbltl { MARGIN-TOP: 0.5em } .prerendered .bookdetails { MARGIN-TOP: 8pt; MARGIN-BOTTOM: 8pt } .prerendered .references .reference-content { DISPLAY: inline } .prerendered .para .reference-content { DISPLAY: inline } .prerendered .reference-content { DISPLAY: block } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/toc.html,journal-article.html-sidebar Article Table of = Contents

Brain Pathology

ISSN: 1750-3639 (Online)

ISSN: 1015-6305 (Print)

Volume 19, Issue 4, 2009.

Pages: 713=96723

Top of Page
Abstract
INTRODUCTION
CNS IMMUNOPRIVILEGE
CROSSING THE BBB
TUMOR-SPECIFIC REJECTION ANTIGENS
EGFRVIII TUMOR-SPECIFIC ANTIGEN
NATURE OF THE PEPTIDE VACCINE
EGFRVIII: PRECLINICAL STUDIES
EGFRVIII: CLINICAL STUDIES
DISCUSSION
References

List of=20 Images

Abstract=20 Only

------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/homepages/118497402/bannerforeground.gif R0lGODlhxQE6APcAAAAAAP///wEBAWVlZf7+/gICAgsLCxISEiYmJggICCAgIPr6+hAQEERERCoq Kg4ODu7u7j8/PxEREff39wMDAyEhIR0dHQcHB8zMzBQUFKKiogUFBa+vr1RUVAYGBi4uLvv7++Li 4tra2pSUlKWlpRwcHAQEBC8vL7+/v+Pj42xsbAoKCvX19dzc3A0NDRMTE319fScnJ/n5+WBgYEZG RiwsLJ+fnw8PD8/PzyQkJIiIiNDQ0Dc3N+/v7xgYGPj4+AwMDGJiYmFhYTQ0NM3NzTMzMykpKTs7 O2ZmZhYWFhoaGhkZGfb29jIyMkBAQCIiIjY2NkdHR8bGxv39/RcXFz09PfT09AkJCfDw8Pz8/Bsb Gy0tLVBQUExMTDg4OB8fHyMjI09PT66urh4eHhUVFb6+vjw8PDk5OdnZ2VZWVk1NTTExMSsrK0VF RVNTU0hISMfHx2NjY0FBQdPT0/Pz8z4+Pl5eXigoKDAwMODg4Nvb21VVVebm5lpaWt3d3YeHh2pq aklJSfHx8VlZWXV1dUJCQuzs7FtbWzo6OlhYWGdnZ2RkZHFxcVFRUV1dXTU1NUpKSnt7e9TU1E5O TkNDQyUlJYmJiV9fX42NjWtra1JSUpeXl2lpacPDw+3t7dHR0evr639/f4qKiqGhoefn57S0tL29 veTk5ISEhKOjo/Ly8rOzs0tLS9LS0nR0dNXV1aurq9fX15iYmIuLi7y8vJqamnd3d1xcXLCwsN7e 3tjY2Hp6em1tbVdXV5mZmXh4eOnp6ZOTk7GxseXl5aysrMDAwOHh4cHBwZubm4WFhaamppWVlbKy ssrKynZ2dsTExHl5eaenp8LCwoCAgK2traSkpMjIyOrq6ra2tri4uOjo6IGBgW9vb7m5uZCQkG5u boKCgpycnHBwcNbW1p2dnaqqqqioqGhoaLe3t7u7u7q6urW1tX5+fo6OjsnJyZaWlpKSkqmpqcXF xcvLy5GRkXNzc3Jycp6enoaGhnx8fN/f34+Pj87OzoODg4yMjKCgoCH5BAAAAAAALAAAAADFAToA AAj/AAEIHEiwoMGDCBMqXMiwocOHECNKnEixosWLGDNq3MhRoQAAHzuKHEmypMmTKFOqXMnSZMiQ A2G2nEmzps2bOHPqHCkT5MKeO4MKHUq0qNGiQAm+GFPCQpIrB5MenUq1qtWrWGMKFKBAQR0HBhjE qKDgC4IKlbRIyMq2rdu3cEuGvGGkiYMSH4oEGiKhkgMAVeTgOaDki5ENcRMrXsw4LoUjiJJkELDh CIA0qBCk4XTilgVNbOw4WPLBMkmpIFFH9VlQdUTXrBnCPjm7Ys/aEAXIfInb4sfeCXXPhJkUtfHY BIGDvIPAwoYaMQo4wVSCgbgYaggF2XPDHhdcH7o0/ylh5knL3w1fau0InDjy9+m3PnTfemL74Ahx 74ZvEH3u9RehJ5VwGB1XX2rrzVbcgD2tIIcDHlThyyBPXJDGHpEcME0DCPRygitC8HKFK66UgFgV OZCxkX8/tUhffq/lBhSL8tW2330zxgjbfh4lJ198B/aXXHHz+VjkjgACGRuR+NnXn2tzTUIGF4SM wcUgYrzRSxO2IPJFElAoEUMMDXDBAwLtmOHCEYwIQEUUNyT5n2w+2ZignPHZ6Z9qyuHZ45L8zfmn Q3vyidxvNAYJoIIFLvrjo04O+aSPfbJoJ0gZHHFBB6mwUoQROTwBiSsMGDkQHonUEEgvOnxzQD6T bP8RZ6NNCgppokBeKiSkKxGI65Et+klrpDAq6Vuwx9IpXJ9+/oogAAjEQMYJCQBCji8D9PJBrQJt 0MUdA3DCTSggUZFBAbbRxKyi7LabbGMSqbcaQxdYUMIYpSpr0gtaWKDFA7sSatAFGdhbgge7vphr wAuV4MUKmXRBxRCMlADEpApRAEYhqaALQBJmqBhvQTc0MsDJKA/QRxtHKLCQHCgjkfIgUbD8RUVK 2HHyGYHKtEQfJytBkAesoEwDRCYP4EREFISRcsxxtNGGF0s8ZILOSLCywoBeLCLz008vMgASTlAA wAF2INGHC4ZCK8QAaWzl2geD7CJLMWVIY44ogLT/cUCxAz0hhMwuXGSAHEIkI4YpKNBSzTaHDIER GGHYswkHxaCAwgi/pJpkSG0ggUQYQDKQxslvmHrQC1W44EADI9hRiBc1MEwpTEtU4QUAPiQSRhsX YOSAMQEUb3zxgvAhjzdRUCpQKcdHT4cqfHSyjCPBR2SL8Xmge9ujbSxQPCQEMdCK8Z7EIPdCxAfA TERX6BH98YKoYkw6mHDh7hnG//CIQuGYnwCNx4HgFaF4C8iBQwBRPCwAyiBhQMYrBhgAQayCExkQ liOMB4ZAHSgkEgBEOQxBwRbU4hCmkpdBzGAJa0yBgnPwBSt+BJMRFI8Au3PIAIznjDsZxABrAMIe /3rIg1+8IQnCqo96lvAIBUQhE4GIgRYwggAMBIAAFAwAMDaxgveQAItZLB4I1lEEIPngGFcsXiBa k6gIhKB4DSCIC8pwwwCUgoYJsWIANBCRBMAhjWHEQjCqpjoKaACQoUAMQpYxQDBGLxoIOwEEApCC CjhkBiwIgAiKVYNwYGF+fFDF/Iphh4V0YALFc1l6ZOIGU8wPC6AAQfQWQALT1IlXAvEBKvLwSlLM zxA2qJ1BYoCG4nUDl1pJgisDAIcEGIlAA6nBExDQBWfYwgdOMMBB1uAEM0TgA4/AQw0oYQaE1ScJ gVCBCqBwByOUwFkMQQARiocCWOBCDBwgRilOcf88WGjzR8oonh/iIQZ8cuCgzLjG8VowiIf04Qd1 fMYzDeJGOBLkASg4HgEy8aw8Fo+PEPHjFT8RjYOaVAylmKTx4HCzZcGECkw4HhrMwyMhiEEYHMAn CcZxxTwwA5/4xIYKzCZJSlqyIZjUpEIGoYvjfUIUaZBDE3hAg0WYQ5bFo0Mt/oaQU6aySAAAAiY8 YTwQiIERYYDCEMzQCBh04nh5UMGg6vCM44EiHHGgARSaUIheYEISMo3bo/5QvCmYoSFCgGgAKPGe /SwhBzl4QwEYwI5JrAU9QHhDBHjwBAU8YQkWWIIPcoAAGgihjAapQBFqkAxeQGJ3KnyIPIvnBAn/ HOC2B8gAGKKAA+NhgjUfqcYVkcGA277gAMd9QSXeIAzjYQERDTGADRooSyvw7IEEqWgA4jiQB9DR kS1oQhL1CNKHJEAKAVgAIW6A29tK4AUIEIIIjPc+hKCieD8QRPFKeSgAGMC4t70BYQNAghLg9gUZ MMBHPjDJSl4yk5tESBA+WbxOqMEC5iyfA3YhA+Mdgw1dRWUAVMmtsAoDjAuwxBa4SpACYJMYxmPC LJApEC7wwXgtsEMlLlaQC1jJHcbrATt89IRiBsAUDFGCOoqHjsLNaysxQOIKBmCEaRbECYoowQsU eZAMfKEGgNgCDZfghg5IwAlfOJoHFTLbAGxr/3VvDcAwJMcaElwRHgp5QD1eGAAi8HheVVCsIiYY gFRoJSna5a5AMFo8ZahUDGZbCHn7+EcQnEMhSkBH8bKgiIOsgJeFtkTxTIFE2wkkEsUjR4YLUlQH IxXCCBGCFYqnCkasRSEmOEFdi9eMvxjEqyOGiAGaW7xX8GDV73HBIUgYgCzMWHVqIGvxakFIhRzA FrMOgAwIUSMA1AOVLFA0QhSB1eYFLCRAAEITUOENfLShC8QRQgPylTCBFOAFvmMxAK6ghjq0ARZL gC48E9Jm8QI3JE3oQXoj8SM7TyEYvApJAWCQheJ1el4UAEfxduADW4gvBApUTaLlSMcA/GEGWP8k gApcM+mQ/nEBHL2VQErwieJZg0ZpgCgf8NCADhOgDoMCAAyKZ4N/IkogrT4qQ5Ia4YI0QsSnUIPH fDiQDIyi4gEYBcAKAmwSM8QEmzDeKpysMILEgNAsAASPjDCH4k1gEVxWnb3d4MsAWIF8CLpA2wNA i6kbJAfnI/Cs4PMSHxRBAYjYwh2qgLCPGCAIeIg0b4BbkA14IAgOMMFAfLCFRvRCDneg80TaXEap QC8AwoiNnQmwjMYSxAC0KJ468JODXBQPGgDIAVllkI9bHmTkA7lByfFhAA4UTxeiR0jLzYteGcRc IZyYtSEQsL4CADkA2QDAC7BRPHMED1cwGXr/AO7RxZiEJOkPVmpBMpCC4pFCDc6TExBqYTwk9KTr dAJAHDIZAGxok0bfAy1G5gc8YBBXgAxu5wj4QR8dIG0pgEQEwguyBAFdkB8q4Ha2JCA+wgBjgACR AwVCcF0AkAFBEAEeE1u+FxtqcAYeswElQAOocAh9YAQVUUXFY3AI8Q1YRAsFIVwP1xD1ID4g8Gf9 sUMBwAf/AwDENgf/lBDAt2gZFQA6AABPoA3FAwvZo3wfRWna9nyqkwP8xAIoRBBHMEk/cAkCQQiy xAQKVCviV3QIgX6vpn4EQQ5YNAFBcGhBAhNaEGegQH0EgX9/4gN/FAC5IDRPViMfUQgxFQC1/xB3 AhAGvpWF5rcQkTAOsSAJ3FAQHjBf2Bd3A2EBTRUAXOQQEsAGJlAEoqADoncBbqAJn/MQRmAGkdYE 4lAqRjAGTRgRNhgAOAgpooBFKNBwVzQCDXEE7ScDSQgpL7ADxYMM5ecFsiQIceAnTwgAjCaFH3EL YKR2twQTy+cQ55VecvUTxcQE1UgQ1YBFsQAVAFAJe/dsa/aGu0gQcsgQshYAaFAQY6BQAQALNKYQ b0BhoeB3HdCIXqcQjIBA+kMRyVA8fBABBHEF8lA87pCQD0EBVKAESnBrBLEIWAQBDekfnIA8SwMb GjkGkWYAUIAYFPAIFYgRHuAIdHYBXvBODv/gFRRBeh1FILFQPMSgesXoER/hAC2gbUC3Pj5BCVlV gR9BAXpUCs6EK9eYjX9gNi5QDsWjDcmnHuHYEOO4AOUodysgPyzQacKhAPwUAKhAEGFHSYOHGvSI EB+gcCGgdPnxEUxXEJYgPoKAWjGSAP9QPKeQLx8hiAtBBksWAOtAiWtWEEtghQGACZonEGZQPEyg gK8BTaayAbu2Cs5EEF+gD8WzDKHJEECwBV9QBB6QBEZwAponAV0gAbpBHJaSggUxJdlTBGqQCEHg Bmuwk/Pki2wkEOcgSxOAhgSyesbYI1XATz9QgAdRAOsge7f2EYlQPBCQOnJSlSV3lQJxB57/SAtN eHRfyRBhOZaTsgbAEAB04AbyoQOyZAhjQBANAArFk46cWRBzeRD3uBp6CWsDcQGFmH1KKTBqgJ8B QAMwsQcI2RANkG2kk0QIsQHTUDxE0EEAQAHwYJFUoCNJRAMNNAk/0g7FkwcgRicuQCbjoAKF4ATl lwGJ4HsoyBAFsAXXlQNRgAReoAjqM3rDeQfjplLzsHUDwZwN8QviMwUeKRNGgF+byBov0J4BIAs1 eo1zVDw64D0AAAhYxwh4BADnuRDpaTvJID5Y8AI+cQDWUDzVUBAmwH0BIAkN0Z8GUVQhQFOukY/7 GBKPwEtZsAgHCiQPEGd/gB6IqRCKQJjm/9FtEFEFxSMD5nYBzhgArSco36MeHlAMV9iECqBfAeAN EOECbOADMuMGCPARESKdC+ED2aMaRnALArEEM6AC4MAJYFCPDtFmztAIF7IHmhAE8FAMjUgHcmAQ SLoQBpAONpcQ+7BxIjMQFKADx+drv/dG20UQwlc8fzB1QCAGxdMDJwAgY6oQZRowR7CW6EAQiiBi eFCJ0adta6QadloQdRkAeaBvCrEHs7aPPpEIk7QAFnAsqVA8qzB1iZoQFxoA8UBvuBlPthcAsgoA HiA+VpCH/7GfuNIGxcMCM/QRwXCiNFgbBkAJJRADPPABQaCmQBAIlWmAbcAIKtAPM9QQEv+wBs4U A5HQAb/gBKQ1elZEAHQAAT1QtD0gSsYTAm1QiQCQrArhCh0WAH3wQAegUFNgCZDCBh02Bb/ghNgq blkqhX5XAz8ZANJwmiFRrglxrvDBCvITAFMgkQJxAcYXAGWQYSGxAsVEADzYUfxJdLqKdAGLBpIw B4U7B4ibuIUrCZJwChW3SSHBCOIDAZp3HwOxCxWnC5EGAAnbZbigpS8bkAixBMwaANOALvwjZ+Km LExCMpoWAMSQQWCAnyCAtR4EEyZwBGuwBaHADQ6gBmtRsghxAPbgA2DwC27gBn0AigiBB5aRAAiQ AC7wBTmwuruqR2G0AMtQagThtAexAd//gLQ44LAEQQgvdAo5VBAPQA3FcwwDCxTeya1T9xGO8ElT 0EM/orYIEZbcsAH+6wH+uwE34Aa4QAfGMw0w8QbMNqHIgQqyBAywlRD1ShD3GkYD5K8foYZmu7lO 4goVxwQve5Bf1ardcHsy9xAPMArFkwzo0gDF0wqNKhLoEQhYBAINdUgBoAdG2hAF4ABmAAYxYAES sAdrkQBH4I5yUwAnwAZfsAjRcQEVYAccjBBQoGZHEAN3YAGXwKoQ0WZlQA0HVQ7HoA2kAAEiRgA7 EMMCkawesAIJkAArwAAZQAPHwGd0UAVCYgKARQCGhhANID4EAJ/XalHdFYVb2hoFGwCG/5B8YrqF LidGMiADC7AAkSzJWBcATLAJUPERBRCyfbbDBAEGkokMCzHBA1FUWSAIREu0RtvKq2wFWNR0AOAK snQMkgeihPDBIfygC0EFJRwAA2BqC/EAOMzCANAA7ChMPSYBDNDMzvzM0OzMEuCYAmEAsmCwjjAM 6WULebKha4AHNBAP0TAEUfA3AsADKuCYD0ADkNAFoXsJgVsQZhCTRwAD9EAPeyC3vKhHYvZ3vLAD YEQE1da0Q3nMGiALm6AMOEBhxQMMeOeomqBfqsAJFjAGFnDRFm3RXhB41BAnPVGVhjy/H6EFo9gJ 5ScQ+nsQImXBdNACQlAQRRCx7VABF/9d0zWtBcuEBhhJEKYsEPdKCoHgACdwAh9Q1EZd1ER9BzAQ U5CbwRVnDPObGx4TCS+kuQPRuQZBBqvArRw8cAbhy8VTkACQusPAWLtxCHqwA2q91juAA2791nD9 Cc0Ai0BRBZm0AMAgPnlAhA6RBHiwAlRQAC4QBrcmHWqgBVRwAFpQAb0gDg0pHzmgmXL3CM1zBXRW CXUggl08nOKVFAbgyQFgu2tc0AgwDwIECtlgS+tRAKcHArmgBy3gBy3QArkw23qgDwYcACBwWBT1 tRcV0gCSBuIjAwyXto5sXn9EAFiQAnxACnzAB3nwCZ8gBWIwA+UpEAtZPLkgAn7Q3d7/3d16QAov 9APcLMGAG4eTZAwD2xB2kEl9KhBBYMALMHhOosIBcLBXLWI7XXmYMG262hsKUHMBMIYeUF1oGBsF 4AoWLEDXYG4GsQLXbDwEAAh6iJo18AUqkAiu8AahGwNx0AgNsAiNIAEGgASnORCXkEFykoplBAYz 4ARnIAQMEMFdrEedHSQVGQCtQGJOWwckRAAE0AKrsAlhUJkv0gR1t+DG0w6hKxAgraUnWBD2TQqs mtIGIVIgMAJ1QANcTgNekATcaxBKYNpKvlKgzNPnfRD3mqcOkY+yXASA2gEUGiQr8J2Iqt8NwQvF 0wIY2RuIUHEyoGYJIOCiHRMzkAez/53oij7bfgDbIiAIWPQKaiwTTqBwGOou9bGiXlAOXMAFiOB3 B2ECQ0ADoG4EhaAoWsBdSxAH4EACmmAEaioRPBkoPABRPzADPuG9ilBxBGAKJx0oI1BxIIADav3W bQ3XzXBjcqah2eXbhQzlQkIFb5sOXGXlBSFSC5COyOIG+BUL/EDsbL3Wbg1YFTS1CNHTAHCvDmYc AaqPBDGOAYALjiowk8BsDDoQDjrCC1EI2cad+9kQFAANGKqhFCBqASAFYZ5LZgAFDN/wUMADPPDw D88DQ1C2fYsgMOEBvpBGJDqok/IRN/Awt1YBZJCpIXEBDSAHRHgBB+4rAkEBTtDPYf9QOAigAKgF HL1484/yESvgiduQ6wXtE/cgRrsgN7Y5c6OIDA6w9EzP9EZgBA6QA0GgoCoA6k8utj6kCQjEbY28 R1wIAl7IEC7Avtj3CO3U9GhvBFDwtiSAxH8bAHDonw1mSYbCpwVBDy+EBerz702SAPY9DIbJuXjO EGRQugXktw6hBO1DmQMxBG7HX14t5rv383XSE3GAdU36mMF3rABQB3cgAIcRfwNhAjTQCG0IACug CVP5KIHAWCDhAKGpALCF85yNHwwwnFM42gTQnAORBJXKAiNJowDACFF7M193ei2AbFd/yAhBARsf ANeAx9b+7ugFc4lIEEOgWEjgEAL/HwAQsDQHge5rjpcKsZcEkQP4SQDKUBEDGdYGycsMAQhYlAUO Dhy7AJH67F/oZbZTBBAABA4kWBCAAAECzREIkELJwIQQBc6QESDAC4MZM5pQkgTAlodUMkYk6OEJ JCRHBB6oUXDNjDQRDAh0cKACDQEPHGnkORABBotNegKQgMZiqIEkAhAYYRDPBIsiHvE8oM4iLJJD 49CxqObgwAgpLDYg+ACFRR0FelZoZVGKi04WNQw1mEBKgAUq6A5M4M0ivwp7ARixYnFW1q8wLNqY mfEEhIaB985gEUCEwXBTAvwIIhHx14IlpFk0hKDgHiYWFQgm8yzqw5EGScoRZLHW/waCArpYJACO Ami6Ee1UnNJ0aJAfFjMI/powoQ9KAsEocFFDbcHPAG5UGhNBkbhZat7wgsGlCYIvJgQWqHHABQIK SUQyJ4iAiMUiwA1+AIFXSNKljCtIiKUCKIUM4CJKo6IAohMsiWYsKkOgiMIaq6yzAkhrqA6gCgAJ HOSiDwC78NJLMAW4CgAakrLjqxaL5oihuYEUC4AxjR6LTDDKLDMoA7EC0GaS3BLU7wpMGPoQsQ4t CszFguJILQBsZnKuyIwQ0MMiP3ioSxaLmLhFNgqxE6gDYCzS44EyNUJOOeYQO+AOAJA4hIcrEEEM SoFcSAIBLiRgwActJFCPICXCmP/vgi5GrO++AIQCLaKENkjFole2AJApMy/YxKIp/vjsglEsMoWB NnlKKJIsApjgDIIiCOHCgcxC6zqeCrCEIUOSC2Au+krMayiEBPrGohaGSFWjhOrQjIBMlrURR8cg S0Eyunq8zCAaPExBDVyXJYiBYPr7lc2CmgxgNf3INOEdiwJYxYVUXYzhFYtYACS7HKyxaIJFcNtL ADdIscgKSMQt6M0AlhsxogIUqCMQCyRggwojJBLsgSqYBeAKNhyog80DHKCQzywh/YAnIFTQLIB7 CFKK02WpACoAGfrQ+IxZCYiD0r3Y2JIAX8q0MACyas1ww6EqiKvAX0cU9kS6Vhj/Z6lRykQZgAyY kXA+0KZtzCAdr+Wxsm0NEqKwAFRhRILYBDIBD3niPSaHjNQtQbCEDMAl3ld48MBMglzowxCLspiF TIHMGCZeX5ag64BvKguADp33YtjhhwXyoRIlqtgnkjOKuELrvRhARGOIJKihi2nUkOCLFke0zyIn JDhg9wMkIKOCKpSJt4U1ypxZQI2L8ITL4geiABWLYtmb9ZESQkYzCKYH4OikBbJVw3AZ7yI1JYFl bmrBJmHomiio7ykOc2kwSOwcrcV2KG15EgKLeDtRw4LBFYQBDogEgwKAgpbkzUN40B3vHLi7xhTL AMJQ0gIssYUDGKQAPnACMeLF/4TFGYkgbxDB8C6BgBsYxANKaIS/LAKBQxAuI5tzVEm2kIEtzGAU QvBAHVLovowoYQBkEsASeCCHJiRgBEZYzdY0crsDwgIXYuAAB4iRjTzEKwA96Axojhe3IHgIHRkU iALwFYBdCMyJCfEC/2QAjq/IilbeW1r4eOKNKZRPancZFrEAUAqLdKNNTvxChAIAi9MRhH7V2tFk 0NaTREhCi58QRRrksAZEQGIR8TDX5d6xAp6oqxvUmGIVTWlKXhgECJhYnkVAIAZGhAEKQzADF9jx NIvkgWqxSQgesKFFCCgjCJA4QxMK0QVRGNIin3CDDGfoK84FJyNUKME5RAGGJ/8AgA2NoFe7NJKB MGAJAAz4wEO4sAgANLGGAvkJ1LT4zgA8Iw2p+iLqBrICMKFlPY6wiCdaUjtVDSRD4wCCQOSINAzd KqADKcE84mU+waCPLh+oyA+G6MSCbMMiC2hejRYztoKU7X49yV9PwEAO/r2TD77SIgrsMBTUuBOe 8YqGRtxgCnhiARSd/JcyVGJPjVyAHW15JxP4AE9P+OILcXsmnOKUkSVIhgJRSIMSosCu1P00K1qo wSD6UIhEDGINYwAaRgfiAGPM9GBWQIMGeKGFjKzDIqkQ50C0cLMAcAIAPojFYkAZp4iEIV5IAUAb FmCRhA3kBkR9hx1Zl5BAxIv/GSO6QgkDYIu9yDUAuUAQEHkCBVUsJoACEYVFOFDQjAxho3jbCyAs ggURFiQMIyDqTIHBDE50VmEAsINaZ8qBeglEAoAoB+LUqgdZJEKcKGNDKMpguZnuAB6NIhyUVBAv j6xzIBfYAhAqUQgVsOIOcujCUj27ngsADQA1MAMNNBGNP0ThBBZwpscIcoNGDEC/+9XvLaLwhjUI LCNy0O9Pe1ID/XJCfg+YwQCQMKPOAcADlxjAOaKQkCX0Qb+wEcgGuqBfKPCpdprQrxNGRIFJDGAR bPCmRAaBBCQ4aGAF8QAN9DsJ3ERkDfqNgAmy8wI7IKEPLhAxO4UwgHkehLmD/9jFO4pRBmmYQxSZ iAAZGTeQJwSBv1vesonrCgADyEEIyRCDKVBAi2ps4xDK0q5AtBCIb3hDGE9GwTJ+oQmT7bYnMYiD fhPQ5oG8oBBNwAMSOtCLTCyhEpX4smwS8oIYjMECejnHmB4BUvqYFdCNbrN6Z+woF2m6vpzetKj5 pmcnXsACJRgD3M57pXXCWiMv0IIFtIAuUjOHAmQYQwlKMNpYbxpLYEDABrYBBXb4wwEIKAENEjhI jVRhDUcoAQMqyQoznIEMps71lZna4uwUq1hP3ZMf9Ywlbnu7J57O9EKFPWpprvvd7ZY3oNcY7HRD JCIZyEEGukAOKoRiExW4wf8KhrCGQ2kECA7IAQ/csIdgACAGH0hCFWKQb1NDCaDqVvLJOlfu2NZQ 4xGu97k9hjLnFLnjAc1Kylt8ZU1nXIYAbXmnm5Pvebsbhy44AyR+gYgXiGMSVDhAFHyggEEwmw1c 4AIChsCDIajBCCugByEi4YSib8Gx7cYolHCVbpxP6uRFMmvNy/5pcZP70+buOse9HXaRv3y5wc65 x3NOEiAU4gZ4uIUPXDAKQuziEUbIwANWUIEnnOEGBnjBIQYRhRE4QgId0IIQyFCFC2y97mkveedL vXIaPVbuqqr56N19d29y/rzwti9Q1T3utcvcSLLGTtivpPrSk7zuHigCArz/gAg5XIIaRQhHAS7h jEPUwQdt+AAPNuEIYkCjHSP4QxVesIUEwn31cT+1zbff+njX/dv0Xhbt5w37SbVduzFft/bpbnK3 2xs4GfjACyixBB1YgBBa4IYYZtGGMIiGJ7iBP9ACfCADJHACIEiCN0gk8XtACIxACZxACqxAC7xA DMRAAagCBZAAKGCAPYCCM4iCPQCAKAiCQmAAVFgBB+CBDGCDDBiDDJxBGqxBG7xBHMxBHZy3HDiC LXiBMbiDDyiBxmADJYiDNvCBO6gBCxCwHXxCKIxCKZxCKpRCT6MCMIiBGpCAK2AAMFiqF6gBBHgC BzS9KjxDNExDNVzDKjS/M4IwgAdYAh/4jdNjQzu8QzzMQz2EwLODvz38Q0AMREG0Q/USNfcbRERM REVcRBq8PUcJCAA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/rss_feed.gif R0lGODlhDwAPANU6AP///+J7AONfAOJrAP2jFeJzAP50APro1v63KP6xI/qLAe5rAP6rHeNlAPOa E/yVCO+YR/j08fS0SuadM/Lj1ei4hu2PCuaCAuuXEuzJlvp5AOBxGem1edGcVOe3Zul5APaEAPdv ANmyjPHax+3f1eyDAOd7HeymY/K9fPjly9NkAOt3ANGNSd+aQvOZL9JZAPnj1MiJS/fRjeJ/IPyF AOyjKvR0APOEHfO2Z+KXLv///wAAAAAAAAAAAAAAAAAAACH5BAEAADoALAAAAAAPAA8AAAahQN3k Eigai5eJTujwZDIyCWI6deR0gYQHwAUcJIlwIqArMGqdjojCRTHehTKBgMHQKxEAZx4vECxcBzgO LXkSDnEDDxYjJFwZFhwAKQ8DOooPChcxeSclbC6WAwoKJaQsXiCSKKIgB140H44fEAAVlg0zXSsa IwAqtRUNOg0LbDAaGiYQNjciJ8MmCwsvIQbX2CELG0sbAt/g4dxL5OXmS0EAOw== ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/link.journal.homepage.gif R0lGODlhDgEuAMQAAKzN3u/1+tHo/0WPtXityf6gFPX46gBmmfL38ZC80/nRgyB5pjCDrPbtyL/Y 5vH2987i7NXl7qHGxtXl3OLt6d7r9BBwn8DZ1Onw4QBZlOjy9+vz+LfCqebv9uDv/ez0+yH5BAAA AAAALAAAAAAOAS4AAAX/4CN6QmmeaKqubOu+cCzPdG3feM56ovgJmk9gSCwaj8ikcslsOp/QqHRK rVqvSY3gM9o8EOCwOGwom8/lsRrca/ew8Lh8Tq/bib+HR/Ndk9GAgH5hbm53h4iJiotPHh4VfX6B k4GDCIVvjJqbnJ1UPxWDlGUNCqWjg5iZnqytrpsCoWujZQW2CrQGqapKFUy+Q8C/r0UAwkvCxxXH RhB1ysRHsbO5CrYNubprIg4MBwsSIkkDAEsEBEPkTerRBAwOThZDDgNF50kA9XPsAfTRRtPGZKtV YKA2NRQsJHgAgIA4Y0UgMCDgrF/FYOfgkYM4BMLFdAA4WiziwJfICvCI/6AkAqEcEZcvm030VQFm AI9EHBwwlg9CSpwBAHxcOYRjyZsVgdYsVpGfO5giX15cGswmzJrAsDoJ+GegKYMHxUgY4AbCggHg iCSwwCBBgAEMFqCbt0Du27MWnBFYMLEI2gF538ZFR8ACYAaAnUk4y6CmhbroJCBuXAHxggM3zy5I GWDtu8VoW7KdG4DAgQEOALC1ew8uAwkv65lFC1vdOdV9DzDYnQ6tW34MDGem7dd3AAlsGRxPPnxz BcMMIDyH+zEJVwRgMTTAADYsmHMizkG4B0A5EXVjAzwXdu8t7HPPQy64OOA9gfTr7+lH1zZfgvJD zFfBOQwAkAA6FWB2W/97IAXwTmkEAGgEZkEp9xyEAShkRD4YAmhbhOYFcIAvDzZEQD38cNhhiEGd U8+DzsAIoYkOLOBSjTYtwdVAE1xwwTkRXjABd7moIYFDD+yVDwAPiOhXOe05NdeHDhg2AGrnQQkk SPthaOUA/+lDzgDnWGDiEJjBdSVpb5VD4ZL6FPGmPgqiQ48FsBWFoktpaqmik20CINeVbcbWIKBB DVoPhWj6hRiZx8WlmKRN7GgGBl+dMcGR3gyQQVwZgHkBBUWKkdBCqiXp0IlPotRYlfYQ4MuHGZb0 EZWvytNla3YmKp0F61Vg41g1KVgPZw2C+VaEcRKBWU10YghbAnFyqB//iuiQ+SeF5FxbqJ6+eDuE t2BW8FsC5pZ2rHpaLsWgEgGh0UABmWKQDwH0uHWAR2eZeMEZCuByhhrd6ObAAwOehqxpbhWW1ksW ZKtlohE/iaHD9l2MDgQDHICOoMG55RmWpnU87mm3lkOPx9AeAVhq0cKHsaEJY1mjYWE6C1IFgEHK j7ALqFcyZzwbZqc3R3t88gA+dRzdytFVKssZpdxiAAZPdTZAByKWoxo8Y0nA3bz0orENJv8w8acS NbrybtqJTCOvNdfs1VY3Fe00LgMRJBAyprYUgI0ZZxcCN9t5KqFkKxxXd/gdcsvbwOQckHNgXABE ICIEHUCQwGkEhMlB/8ABD074GLw8rvrq0UQeyATKqhexmroh5k5jQ1A7ASWFt8H678Bz4jogxHbE dGqmhS6UoFyrVx/vYVDARhsQiFMEM4dgX4XjVdCUVRPca9+E+El830oslMDuVu6yOssZx5ydSGol YVgwvQjCWk+EPIq83X3QcdCVxNTWrP1NwR9PYAf/WIG+SVwAS+kgQPNExJkIQEpP/5oEGHQCAAqI wCMMwR9HKKSVI5QwKB8pB1VigiH1IOslwojKUYLCwqJwz4XFcJJHJEKRjiCrJEQpIaM6YhOfqARm G6rIUXY4EWeMyCYO+MgM69DAQORDc0Noi5w4swFWDcGCGaTf0HDjkP8DIEwz8HgWdKoznahdaQG/ 4UtceCMiOQ4oMowRBgQMk5fZpKVnFkhjczSym8QRATSUsUydPNMwvtSjMNqqh7DQIshDTsYxg+kH Xpr1xt9oiZEi2o154MIao0GuApSQTBT5lYAdQuAArfSIA9wRAVm+BnoIOAAYytMDMz7gQJDCDI6Q MMyiuMg9DoJNgUQUrgPxJ0zrw5BePqac+nQGHXU6k4aQ0B8wHUg9dSqUsGZ1pLmoCJjYvB6BQmIh XbklPS85Jq3YMSIHOQA/wPLfHKpIvAwc4J8ADahAB3qADAAAl7pEQD56mSQy5WYIkpnPESLaEkUV Sh3qoBCQ0PGlaPL/g56F4lCaHmUnwBhyCB1tTzjVoaKN6kld7kjnecoUkmixtFoWnSefuDSlMx2C n2iQjHSWYaNlLGMnRo2AO4wqEQkgFAEUWKgIzGjNYLILQuNRiZbIVQ6Muqmr5VxWP2LVmTuqS6z3 MNZYj6O10tCnV8QCwEoh4pzNtIdDVZUpSola00aJ62LYEis5fMEtAHQDJQJEBFDP0BMiwHEDzoJJ B7x4kwGEURBgeJlUH2DGGp1FX/1wGgTgGVrdSKdnA/SqiDpGmI2x9nodG8AyhvaWnhF2adLBWIIi 8trSnOaRhIHlcRZQsbseqy7KGuLIkOikol3Qeaa8mbIYBijbPCZj/z9FpQOlJAy9fTF2QbEsLgmB NiboMwpDvAI/nLC24LmXCIu91DmEEN4IbKADHdhJBzSwgW6k5APnIBL9xJC6JUgHC2y6QvugUIEb vvd3w0ND5f5rI2oBdCIJSAAAQzu6yZnudAQu74NHTGIqRHhe1lAAfGoSnAi9MgEOsPBgLUgAutHr w71bRYl3zGMdhUJegWsA7NSUD2AcICV+o4cjJ1A1wZktDBC4Xw+iGAdgOPhx5OtxJ+IFsLIZYAKI cUAXCaABCmrSAR3oxgB2ZwAUY1ahA7iEGzQcTStE6YWrO6+Wtzw1wpVCwBTYS4T0uxOJoOZKCZCX gNMQPQfIOYoIE//PVY8YkxWiUGj46oeVkWXEJHQah0jRNA0vTcwfXsQjb8MJlatyvZ9wrwB7hgKX afGj3cjlt78lAJtpIYZ8IACSePJsAkAj0drdxdZ07KRnB2i3euDGLhtaDR7hYi6OSqAbgnnNEU7U F2BPiy8VKwpboIOn4YYmlMqxW4IDYItYb0UW2MnGBAy0UQlcYNGo6DVZwDMWVdkTQ/VEpraXaSLg 7mwB5ATQhTbUTgdB0yw12tI2jzAe00irHhJlEIAkc5wXwSOtNDGToKoTOHcz4TrdyRRYxrBQ8LRc piLN0kXlcyKDB0oft4nWhqLV0QDIRcPquNNJhXWOcMa8heFN+tH/j16lK0GQCIGDtcmtA+94D4Rs 3VHDyxmy72z9Rq+q7RZhgDurctSVuZgxkKGcBKmUmIZjAJwW00iDbZ106EUS4BlpOMR3FH0dUYFs 8HGEUfKpU10gXrmGQdaw9ZeXtn2MCrsxUBuUiqGHuB+L2d6jxTGlDfesA7ouaX1LKPIc97OG6vvj b1sUzCcT6lI3PBKuA4ZsYCBwAiuVGlTRpFY8HcHrfkXsZS+NqndlFKU4he53L2JW4NkKBya+e2l/ /O4MmPnNl772H0f96lsfxNg33PbHz31IWOL74A+/+MnP/tYJQASWsPriLcH73rf//q4oQQ/iX/vl +6H++BeA52MCGkZVgAZ4gAiYgAioAwzYgA74gBAYgRIoAyEAADs= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/icons.email-print.gif R0lGODlhWgAUAJEDAMzMmf///wBmmQAAACH5BAEAAAMALAAAAABaABQAAAK1nI+py+0Po5y02ouz 3nyLDwrdSCZCgKZiiYRuyC5nGKwxmObop4k2c9L9IsPGp6bb1ThFUw3XrDSPyFzQxmu5BjDfI2g1 Zrs8kIJaTa/WLQPbzY0DX9sznI2XgZH7tbkMF/cnJwNgeIg4dbcoqCckFGgSONZ4RncpWelVabKX tOSWNRk6OIV4ejpkJrfpU3T5EuNmKIBKS5uJAQsjy0ULi9vWOzxrixpF3Lsbm9zs/AwdLV1SAAA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/txt.search.gif R0lGODlhMQAQAKIHAPHp2vfFd/m6WPXQl/Peu/uwPv+ZAP///yH5BAEAAAcALAAAAAAxABAAAAPL eLrc/jAyIEoJK9g9WBGTJQTEQlmdEmBKMRSGAbPw5i5EDOAybKQCQ8VQOlgWhoDuIAAZDZBgklcC xA5Wp6xVQGqIDRhEGKS2oLkiYGfsKpI5Gfu5macHBnZuBAMpix49M1g+KTUWc2VWLHExATt/DoeD CnFnDzIEOW5pewp4gAtHbytFMDtiDY0xeQdpTyU5hk6jB0mZUmeamjtBbFYdr1ZuOp5tXnishqwx XVtIXa9MYKtstVMAvBLbEdkEc9zh4uPk5ebn6Onq5AkAOw== ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://download.interscience.wiley.com/images/but.go.gif R0lGODlhHgATALMPADhqm7u6u26Uuv///7TI2522ztbW1pCPkYqmwunp6fPz88vX5PH1+eLq8VN+ qf///yH5BAEAAA8ALAAAAAAeABMAAASm8D0iqr04V0TkXEMojmQZMktHgGbrDqnwzqRiVHRuB3jJ FA4AAMGY7XokAWBVGBoNPBmJsBQVCCGKoFCDIq2AUGOxaAyoV6foKB01QwhhWOCAh9fetmhRDb17 b3hRJkorBEEDTQ0MDnpsJgxxQghmA5ICRYJfOS2PnC8JeSEKCaWmp6ipoQEIAisGUAGys7S1tgEH ByoICLm+v8DBvwUeWhrHGh0PEQA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/dot.CCC.gif R0lGODlhAQABAIAAAMzMzAAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/icon.bullet.orange.gif R0lGODlhCQAJAKIHAP/AYf/Ri//Jd/+hFP+zQP/15v+ZAAAAACH5BAEAAAcALAAAAAAJAAkAAAMq eBdAFOqIUKogi15QQOvEYBDFMJRGahTGSajkwBQvCQgHwVmYIogG3CEBADs= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/dot.clear.gif R0lGODlhAQABAIAAAAAAAAAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_here_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISAABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxInRgSQcMAAhRwPevS4EeHIjwczXiNZUmPJhhAphnR5rWLM gxhnuizIU2BAAAA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_down_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISQABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxIxaNx4UOLEiACubRyJ4VpGkh1DHhwJMqFGhSEbQqSo8mPK hwkx1rRZsKfAgAAAOw== ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_elp_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAIJACvCRxI sKDBgwgTKlyIEACAaw4hPhwYseJEhhgzatzIMWFAAAA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/images/sec_up_small.gif R0lGODlhDAAQAPcAAAAAAAAAMwAAZgAAmQAAzAAA/zMAADMAMzMAZjMAmTMAzDMA/2YAAGYAM2YA ZmYAmWYAzGYA/5kAAJkAM5kAZpkAmZkAzJkA/8wAAMwAM8wAZswAmcwAzMwA//8AAP8AM/8AZv8A mf8AzP8A/wAzAAAzMwAzZgAzmQAzzAAz/zMzADMzMzMzZjMzmTMzzDMz/2YzAGYzM2YzZmYzmWYz zGYz/5kzAJkzM5kzZpkzmZkzzJkz/8wzAMwzM8wzZswzmcwzzMwz//8zAP8zM/8zZv8zmf8zzP8z /wBmAABmMwBmZgBmmQBmzABm/zNmADNmMzNmZjNmmTNmzDNm/2ZmAGZmM2ZmZmZmmWZmzGZm/5lm AJlmM5lmZplmmZlmzJlm/8xmAMxmM8xmZsxmmcxmzMxm//9mAP9mM/9mZv9mmf9mzP9m/wCZAACZ MwCZZgCZmQCZzACZ/zOZADOZMzOZZjOZmTOZzDOZ/2aZAGaZM2aZZmaZmWaZzGaZ/5mZAJmZM5mZ ZpmZmZmZzJmZ/8yZAMyZM8yZZsyZmcyZzMyZ//+ZAP+ZM/+ZZv+Zmf+ZzP+Z/wDMAADMMwDMZgDM mQDMzADM/zPMADPMMzPMZjPMmTPMzDPM/2bMAGbMM2bMZmbMmWbMzGbM/5nMAJnMM5nMZpnMmZnM zJnM/8zMAMzMM8zMZszMmczMzMzM///MAP/MM//MZv/Mmf/MzP/M/wD/AAD/MwD/ZgD/mQD/zAD/ /zP/ADP/MzP/ZjP/mTP/zDP//2b/AGb/M2b/Zmb/mWb/zGb//5n/AJn/M5n/Zpn/mZn/zJn//8z/ AMz/M8z/Zsz/mcz/zMz/////AP//M///Zv//mf//zP///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACwAAAAADAAQAAAISwABCBxI cOC1gwgTCrwmqCFDQQgXJpy40CFChxIPYsCgEADCjRsjerwGEuTBhSVLXss48eTIlBxXemwIkeLI li4fJsR4E2fBnwIDAgA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/tf1 R0lGODlhXwAzAPcAAEtHSBoUFNTLxoyLjJOTk5ycnO7u79rZ2nNqZ7GwsGNjY+bm5yQYF9HR0eLh 4mtra/Dw8WRcWs3Nzfn5+d3d3XRzc+Pb17m5ubWrpsbGxikmJcLBwoGAgKmpqcrJyuvs7NbV1ba2 tsvBvDUZGdrRy/74kb6+voqBfkcYHPPt6m1lY4UCEA0KC7uxrDQyMo2DgG4EFqWlpefg3KKZlNzU 0JmTkhENDlJMSvX29v+6NX59flRTU/778+bn6KKiotI3BFtUUsO5tF1bW6yinevp6nxzccG8vJSK hq6urvtzEZuRjaacmJSMif/0eevq6/+PE//HO87Fwezq60E9Pefm57yzr4aFhXl5ef//yero6UA6 OP7+/oJ4dejn6L3JxTk0M4Z9ersjDKYQDbCmoeXk5VsTGoB+f+fl5vDv8C8sK+7s7v339ezr7P79 pOrs7FkDGP/OS+7v74l/fHhvbO/w8OXm5hcOEHx6egMBAauqqpiOivP09EUEGKCWkWhgXujp6u3t 7aifm5CGg4OCgjUwL4F3c9hHCuzk4Me+ue/p59HNy87KycC2sTcGGMXDw7y7vIR6eODf4ODY1e3s 7fj3+O7w78/Pz4B/f+dOD+Dg4EhCQeXj5GFgYAgEBVdPTbW0tbCvr6+ur/+aIdXU1NDQ0D03Nl9Y VlhYWU5PUBQQEAsICRASEujo6ejp6eno6ejo6Onp6uvr7OXl5u/v7+nq6szMzJiZmWdoaHd3eJmX l+3u7dzb3NfW19/e39PS0sTExLe3t3BxcIiIiKioqOfo6Pz8/X17e56fn2lnZ3l2dri2t5CQkJaW lm5ubsC/wHJub3x8fNra2sfHx/Lz89fY2IMzTrOys7S0tNnY2MrLy8vLy5+enoJkc8PCw7i4uf// 1ru7u7y8vfr6+8jIyPv8+//7+P7/9qurq+Li46usrOPk44SDg1dWVtDKxq2npqinqIR+fK6srTc3 N6empzs3OIF6eIF8elRQUCIfHv3/5Xt8e4+Pj+3u7g8MDf///wAAACH5BAAAAAAALAAAAABfADMA AAj/ACEsoIADEL+DCPnFocMwTsKHBz/g8HdBGDgcDiHyozNtGgQ6Gh8CmuAvAS5SlIioVAmrFSxX RACxoUWLGDFYOF/BWrnS3zxOxSBApDMLFiAIBuhk1CjRXzMACujs0TjNwJkuMSHE0RWSHyB/Gx4M iCEuCxFXC3rY7PHBgCusBmLVefWqi1oiWfLm9XcF3wV/D+lM6gVinIdesJSGbGosxh1S4iBO65LB 2qduliJBqNT1KwEf/kZtkkK3R9pWgM4A84HEmwd0k1ixctVjtqudeL09MwPN31I6gA5YAhHOm69R ZGYtTdj0jjAdoyLz+zBtTxxXGYB1sxZOmolom0N+/zVSYcAycrB69KDdYxIZYMyO2YoxDwkFQK2I 9XilFneWbr7448gHGcUBgQO+REMBKQkOxwZIEH2whz8gbONLMYBwBQE6EIjTwAbU7OJBA9j80g0V Qmk0UjGfDLDLNAuwp1MsGSDRjQngSNPNOxe88kErPcBCjGyuuJIFDhhRYtBBcRhAwSgK+uJLL9T4 QkaKD0mIAyX+iPPBkv4AgwstwjnzTh61PJkBBdMsh5AUlBggjj8QnFEbFXUQ84E6F4RAAC4+SODL BtYcYEB6rSQqGzFdhAQcNrUMZ4kl0fDSQCZYMrfHBB8MRUst6FiyTTAKLNNNL7yMA54BGrFBCRpU 3P/GSh2s9CALMXT0cowCq+DTjAkgZPPJKICo1Ypsx/bQqEZ0wFKYNKRYQqIvtTiQKUIScgrRUVsY 4M0lD3AAigTRgPALNUi1OoEBshAhJCv8LbDALLtAo0EnLqyTATXdgAJCsawkmh9MWWi0EBW+jJNB NwxLUIs21ro53aadQmTALJls8I4PeYDjjAk38oIGqxCxsS4VrwQMbw95smEJAZwoQEAIwFxwQR4N ADKkojfhZfAsXYwyTjgx+BCCBOOQcoZiWVJscByZaHOBNcwMUIA1ITgTzcXqGtBFrerBMmt7lvhg ywC2bPNZDOeQEkt66qlF5M9ERHPNOjtwQsA8Huz/IoUBEmdbcUKAGIDGJpURcMoUwRCQQAaZzELy QyYbsEAW+6llWnsNvLOMAqgIccVnwEQSC9g2DUlMK45OcoA1g7ggTzMDZIBO4Uw5ve0sTnSDhC3y qMLOAKD8ssm1CFVOxUrE1HGGLGcA4osPAwDQCT6nWOGDNWfQwnJa7g4Ji6MGUGPCPMvsY8s5Hpyh Ve7abgsIGqRcU8DiD2yvzSQGLEn5ulhJVlrkBYho+GAfqFiFPCpAAGY4gw12qUPcWuIzZhkgGiHo gDWmBowGOAF5EdEd4SYxP2xcQxgPaMYVmGENkZFQIQmJQ+WwsjnTvIIYsUAH7FCBCgUEYwDHoIZV /2ojm9NUECIGwkYMmOGDc8TgGtFQwywWI8IlAWISk4BAJNJRgQcEIxjC8EYk0GCQF/qvcgsAm7xM E6MsXKAZ7IgZJ6yQgF7E4gwLYBQx5KUyJPZvEtRAQi6GMQ8CdAAbEECDxCYWP68A4oqTYAMaHIAE aDQDFw+wwgVgAQGD+I9JlZNFDXtAhTMsTw0maEYPT8EOHSSgC1KggrzWKJsesI5JcYiDTGIhC1K8 4xjACMUybOELMk5CIcsRXAwfKZNJUMAbA7DCMqwwgAsQAw1qUIPhJMckJ8TpVqzQzwDP4Ap0XMAK XmyGAq5wjUx0oZRp0VwXssC6XF4RgmTIRDTGQf+AfVgDFBxYRzcisQBYsKFwuQyhtnI5CzTMAhC0 WEAmRgGOfVxhEFZgxjVGoY4FyMIB6IAF1/jhTQPUIT9pjIUrZJGJXTQAHANQwC0U8IBBWINSkXBA F4Qkr1a4ghVNosVHe7GLUWTAGeGwwiDy4IMKCOMCzvBFJigQCTI4IaHK1GUXHJCJSFCAF9rwnUVx sQ5bIAEctWiABLQxjgZEYhLKMRkgFvCH2fRgqthoQAZMEIp9PIAdp2iGMOZxgXHwYhcUkIUTaMGK LgwpDllARzRGYQltZOAXCRjGLSoQgwJwYhAh6IYzPMAgXmTCFbkU3Cw+EImESUNhGQjBOQqgAx3/ cEAHwvDBJx4BDm944xe1kEAvDFCJUPq0Fx4AhwnCEY5HdIAZV3iATB+gD2YgQRkbWNgGLKEOInTh Fa34ABkicYAGjOMXG7hAAYLhglvMA3guoONlsiEBbEQCHUSIQ7YAEQd0RGsc4HjEBh4xDGZwQIU6 qMAtoLG9RygjHs4gRS1AQAQ6oJEV1NiAMkAxjHOEIgEEgMYDZhozBeCiAOk4xzA60IFzOGMXsLgh FShwgFF44Bfe2MY+BnALeXDCFgpIAwAqoA8r5CEcGRgFNg7ggEm4YRoTAIQTeBFcR3wCHCE4BjP8 KoRmVCBmuNjHZ0IAilCYQBqXmoQ3AVGHXmwA/xjhmG0H5rEPHdziFDtgJSp2oAAOCOMYMUAbEuIR jl2Q0gGz8McWcDCJTEiAUr64hg+WcQtb1GIUtQBHBqIxDX94+tOg9gc5JqDLOESCFAegxi86208T kCIaDSAFBbqABhzMKdSenoZXepGJTNTCBL8wwTCEIQwODIA7GQDHLxxdi5fwQ9Gw8IcJhJAMZFSA A9i+hLaj+wAzcOASgxiEMe6gA21fggODqEA8QGDtcptbB2bQtrd1kIwKXIED8cY3vAeB7Wzf4QC5 UAC8b2tbHdzBGPG+xB0qUIE7fPsSZiD3JWrr7cZ5+hYsaMYU/sHxjnv84yDvODuYgQ8ApAEPIf9P uco7vg12fIEeq1i5zD+uAU8/hR6DQMY/+sHznvPcBizgOQuG7nOe/4MTft3GPVShiqIX3QapALrT fa4KPORiELngRAA6MfWue/0fLvB0BTShCmvv3AZo7znag452GzzdBkdnxjrToIqg+xzoTFdFAAiR hn7k3e5Ut7pS5WGDpjvdBp3guCrc7vV+gN3TD5DHACqQCq7fvR9QDwADNr/5VKjd8ZzIBQAeMIVU GL7niw9AAFIRABcQAh+sDwALFh/4bZjBBf9gAeMxn/jEa0ATmti6Kjqh+6k/3h9m+IcG+tGJ3f98 8yNAQRlQQH0UjCAAaQd9B/6BDw1IvecsSAX/IQjxBUK4oBTmd0Eaxm/6wFtDE//YPdD/wQBCmL78 WsBH7lnQCdoX/fiD8A/Ex3hQh3YMIH1lAAMwUH1lMH0MEHVwxwnn8A94YHlpp3saoAHd9wWecANa UH74wAAuoAFEx3NVlwAAEH8XiAca4AlaYAqBsHr/QAim4AkR8AV4AHg9d3wcoIJQ1wmdEHUMMAIN 2IDWN4TSZ33YF4F5kHtqV3UsEADdpwERIAeacAMREAGeoAEjiA/4UIInmIJq9w9poASmgAfK4AgR wAU3AAY0AASCoAQaEH//F3b+0INolwp4kAZzmAoj8AYw8AZ88AbXtwpDOALRxwBod3RNaHeI/7cK uGcDDJAG+IAAgTAFfrAEguAJpXADGiCFgBeG8ccCFPgPNfACi+APKSAHSnAEJxAIitAOisAENcB/ dehpeFh4eLANzsAAnfAGYvADYSAGYgADjTCEnDcCDGAHTOiEfvcPQmAJOxB/ngAAWDgFcxAEQxAB QIAAXxCFqWB3oogHNjCNp4AIN1AEu1AFCKAHS6AELVAIRuAONxAFnECHO2iHufgPmpAH6+AF3LAC SQAFcJADooAJK9AIygh919eMdocHAZALgxUDACAHYGAKfhABCDAGVdAHRzAESzAFeieOeICCApgM 6PAMoKACQBABYCAICPACSzADLaCJheAJR/9QA85odPr4D1EXdf8QAABQDT8ABW3wDVjQBDmAkCjA AKqHiIrIiM7odrmXBs/wAidwBC9wBEegAieAAYEwBnoQCH3gfVIniqlgDBVgBCBgCmAACYJwBFzA BWDwAgIQBXqgByqgCUuQBjuXj7gYfxA4e52wAqLQBuawBTzQBnDwBGEAA8oYfdaXClKpg0zXD2mA AGAwB5AgB5CgAnPQB0PQlZCACAjAdUEniqT4D56gAoIACWAgBy8AmwgQAYiACHNgCjNgCt74lzwZ mG2HeanAB2IgCk2ABeaQDyWQA0kgBoR4iIgYAJXpcxgoZIXwAoLABX4AmkXQBxjgiu0Qg3X/53cl KYazRwhFwAUqEJsvUAQIcARzcARBYAEIMAPwAASE4JuO15M/h3YBMAIrEAZJkANN0ARQkASPuZCH uIz/oACNSJ0BoIH44Ad6cAJAAACmYAoqAAkiIAJDEAVB8AXER54maXQMoAfPMAcvIJvdiQFjYAEC IABMUAVdKYaAeYc++JNECIhhYAiGEAYrAJnLqHmIeH0N+qA+J374YAMRig+qQIWCIAJKoARVEAU0 UAWaMKKi2A94gA+aIAdzEAEnMAMvEAj+EAUUsAbtEAQtIAB6CX+Ax4M5CnWSOQJ8wAeNwAJ2EILM aAdIaKScgKT9MHQBkH9BB4RPWgRKIAk0/1AISyADMhAEKkB8s1eeO/cPpRABLzAHHlgEY9AO/pAF FtAOKdAOURAFQ6ACN7CTctp2eRh9yhgAq7AKP2kHfcqk0TmdQtcPAaAJadB8P6kFKgAAXukHGACj iOAHlLql/OgJcjAGJ0AIc0ADJyAIS1AILTADciADJDAECAAErNqTwWmAUGkHurd5tpoKEHiI0hmo OzmoLDAFprB1BqgFNwAEWqABXzAHVXCXQFB3lVqi/OgHYCAAMpCbUaAEhDAFfRAEXpoCIiAHEcAO 4RqY/el2sLqMNmAHAWCrHWsH/eCHk6mrQmcDGqACfqAB6ooP0hoEL6AFhKAJCDAEInADWv+KB6Ag hvxYBCpQBeVQBRHApgigAowQBVoABGvACHOQDKvqc3LKdm33n0rosau3sf5JfQEAeoI6qOp6A33g jRqQBprABDTQAkDwBRVJAkvwhalpqcwngl+wBCSQCIwgAlEgCGDACAIACe6wBi0QARWAD3jgtOLq fJJIfQsJq6tHpE3peSQrdKlwspyqBVOgAjNAAlXAipCAAYdwA6oQjiQqhnCHD6UAACJwCBOACJKQ rVcaBVtAA3PgB/eAj7+Jo9nXnweIuGUQpMpYfctodO6qg1ybCvgwB+qJACcwBImQCC2QCBZAApCw eoa3pcyXCoOgCaaACCkgAwIQBBhAA1H3kAiHoARCcAJ66Hxy2nWHS327uwLTR32KuIPB63R6x7Km 8JGBcAJKwL1RgJuwt3vUC3caAA/IAINrcAh9oAcyUA5RgAD2MAD56Xz7abFdx3qHWH2xeruPK3Sq wAAhSA/bSQg2oAl+cAOE4MFsZ4Ju+3M+qQAV8ALeCQ8I4KKFkAwPIJ0SPMG263V5GHuq53YaPL9T F4RLGrJoV4FNp4iWucI/l3j4IAQ3YArbEAj1EAH3sHEq6HTp23i3e7G7t8FUF37qynrqinfCS72f h3IQiQ9pkAYMgHL+p8X82XhFJ7zyu7VTN3R6vMdTh8Z1zH8dl4N0/HgBAQA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/tf2 R0lGODlhXwA2APcAAP39/bLHYCAaGvzn5q5JFuXpzKurrMfPtYeGhpXIBarJpZ5rUkpISXCaA3II cJioT8PCwrKys/qJiXt6eoq4udW4qOrc2+7u7vf29oayB8Wxwqi62GRmZev1+NzW7itjZvn4+KKi ooiWrsbZ3CeLkE0DA/Hw8HmmAvROAvLy55OSktbV1W3HysjTkmyLUtTm5/3y8ZucnDlRibAbc+bm 5uHg4Orp6cu6Bs7NzY3KzBGMkk6xtaO5tSunrmyA62+rraAwfY+yJr+/v9/e3tnZ2W2Rj8rJyZZm lNbIwvy+v/7Y2M+RWtHQ0Or///h5eNNXFJ2uwubn+crQdHQscbPGxrUwALvS1tPYv4eanKjKyvrJ yX6MsdnhwHl5l4kLA/Ty/WUeALavAMk9Aevk4rq5udjmq/VnZvalpi11NKGendXolfFOULGEqOis ktarkxmstKeht/r49F10IOzr6uHV0V1xfFJTXFugouv/4NrY2BSboTMzNuUJCoewjUZmqDlXm+5r bNr1/P3++717W8mTgPTt/5JVj5uNiwh9g40uA+3t7PIrK8FtRkxlmf/4979bLaO2pfj//5OYguqi orW1s9PT0q+vr8vTzKalps/W293b2vyvscnh5+XZ5N/n6ew+AK52mPPy8b+hpMd2ovn8+Pn1/8YR Fbzu//r6+4WiguPi4v/7+9vM2tXc1ent4FGbnuTKvZqZmuTk5C6boLy5v+bk7blAh7m4t8XFxdXU 1M3MzMPNzMnIyPX09CNHlI2MjVxdW6moqJaVlujn57e3t728vcDF4s3Jyd/x4LMFALu7uwu4wbrO 7aK+6/v4nBM+ks/Pz/L88pmusWJ6e3BwcOvq8s6CXO9fX52FBlBiZ6SdAPPz8/P4+mBXd/Tz88jH yZKRmZiXl7i4uWyLF/SZmid6f8/U1dbT1C1UoNaKtcjQ08vLytvb29jX19ff4dzZ5N3c3KeiGJee yJ8lJcfHx97t8uwfIENbnl9yoK29v38pKr+nwba8xrbBrAAAAP///yH5BAAAAAAALAAAAABfADYA AAj/AP8JHEiQYI1glhQVXMiwoUOBqB5KnEiRYQ1LZExU3MgQgBAhEJQVC6GRo0mKiiwZwAXg5EkT vCAYIYMjosubDzEw7ONi4JEpc3AKhCBMmTgQQpMuBIFrhcBVAhWkEiRwH5ttSpEKJEVqK1WlOG0I wQQJTQooW+Q1kpW11zYTc3oJNDQlWi8HR8AmDQZJAT9fgJ9teYhq24U5NubQUEWkEhNoTFaoCkWD CJML/0zs0yCQEitvv1SomAChIABcIRCMjNVSr0BkaP5t8HXPDzp8Aw0Uo1GDyAomjysRGSJLVY0h NWTZ0LhKE9SBdAuC4GBnwi9VC4lhiSAuViybrl1B/wKQCd2fP76g5IagyIaiC73AOzTxY9Yd7AI7 nQNwhM3XF1QwNIAj/xA4UGuuEbSFDPjIgJlQWSBSjg45LORAXUzk8UI+BMEwQBKLOBHHIoCAhQE8 itSgywUICqSWCH/oJJQViOigQxYFRXMhAmmssOFz/2gByBqbSLDGNWYMoBQ7CMQQywTBQKMLLrog AMEGjWzxR0k4OZLFDljINZAglzjgQCsCjZAPglpcA0gkm9gziQRagFUYQ3nEgSWMriGRh4UODAQg QUqY4cQ/SdhTpBIJ/gNAKCYoMgcIc2xxTxd/CGEEBCAVo4xIlEQg6qgGBGPqqaZaUowKHIwqjhCW mP/ZDwQQUMGDEcK5M4mbFkxiDzlO1LkRJdQAwwADe+whwLL+NOvsswKgs4cfz1Zr7bXYVmums3YU 8WwJXnjhTwmmgCuAP8sKkCwDdnAwQQjDEMRAtukmu64ddvwhgwx/7HEssnZ00cUEBFMzAQNgJJLI HtlMQE11BVMjMQMGc2CxmcBwAAwWWLBrBwP6zDPPHvqYInIJ52a7B0G5YFIMPZXUMIwJLRbkijPC 4CPCPcycksMGzfTTQgFxoNJBJE1Yg8ITT4gBi0AKLaSCFQRdKGiAA2khgQQDbLLG1hYI1IsiNMCD Ay7EYEKNCjgVoM0ND/gABT4PBMADD6mckEADqYz/YMXfnKSRiBcEwCIODhe0s5A6C1hDh0AOADGQ FdIQVKQESZxhhgROKNmoTXG0EE88LZQixdsZ7D3O6oFEAgUW0kRyCiFtWJJJLvAIodWBbohRBQFj /DOFIQPRkAlBSWy9CbBOmMGoa5akIeY/KWAThjN43BCGFLeknsAJDbhgBRWccEJFPk0ItMI6lsWi DHiRMPJ7FU/XgJ+AQ2pBzhpOkOO5UrdAgDDu9w9BuOIAolgCNgLQAmOoQA5BkEILrvAOZXAAHFFb yADSYAEgIaEKVbBGBwpChgcRBBD2+McZ+HAGveAgNIpbyBce8YkaMiIKc6hFN7qwDw9wQyCy+EUa /+QzkEpkgQUsoAAEWpIJcESiILrwhxAWsgoY/AMGhGBLUtohGlw4JBMECCMBvOCGfxxDHAAwBwQs EaoaoMISv1AGQVZBAT3ogAQk0IEeKAAVdywkDXswArKwspBA/BAncwgHAoixEAPhAgHmcIcYmFYF JETiF9P7h1goQQZcBIMaCGiNI16xjHJ8oBwkWMYrCLSOeBFkDttQhAAQwBBF5AInw7AEAgygwQFQ oGMIgMY/6vEEFKBgEP+IwBQZAoJK5EIXHGAAJgQSih+woAez2MEdhiAQI6yjIEYYgk5MwKWBGMGV G1FEAUzwhT0Io5wCsQIJ7rADPUxjIJEgxCMGEf+JGvyiIsUo1jTpgAAq0GAYQOrFLXaHAWKI6QIQ qMFAesELeHCkAA/IQAaC8ABKNIQCiJiFHe9gIIE0AQoXCMEtN1IMYyEgFkgIXkFyQQyd9IIS3BzI BYwAjcbwgh0mCUIDGjCOoQaAIefAwizuWAQqELEdwFjmRLhBg0hEol0qyIMsiBEBS0DgfkTQRSV4 EcOCXEAWw6gZRVrQgBOALwMtKAgGYvELC7gjC0BlSC8YQESGDGEQjyDAIxZwiH/gYAK8/McKyGAJ S4hjpbsT2wUu0FeTpKAMLVCDDQgCAAggYJoTwYUdaDARa3ghEQSoQjKs8URUjGalmjSCOIJBCSb/ kNZR7FDFBUwwBHhUtiKlKMRCBHEIBsCzIaoIAS8iMBE6DOIJBHgCI5BAEF0Aww4LIQIucEGwytQA UvCoxBDUWhEbCGN6I8gBC3bwAytORAWV+AcHJDoRA0SgFk8siAeAEYD+9rcWAqkBNfyRtgkIAxi0 HMJvKRIM5v5jBHqQEAnesAPM2GAFlajECmQ0lGAIpAg8YPAhF1KG77nVrRnoBy0ssQ7dFKMdQ4CA LNjBDvJWRBHC0AmEdYDKHuygA3nAhRFWMIRKCMGEwTgHFSCQjlGMQgP5ZcgFYmDjjJ5gHHIYxwky EAAgAYAGNhhGKFRh0aSEQI7/yAQSd/AKAGCg/x0AiIABYgHnGJBhBSoIRwwEYIsZAGEGM9iHQ9ph CYbMIQaYCEAGtrzRAHxhIUzIiF5oEII5wkAUHl2BLiSDi2+sYASBgEIdOsADBvgZCH0GBToLso5i LEQIvyCDQGpxhQNcYbMMwUFpXBMDLxZEGLHAABFwUIl2tIMTdGjDAhaAmTGAwhbQBgUGhDCBUCyE ElL9B47DkUGK9CZBK4gFQ0LAtsxgABVLEIMYjEmACgiEGCpQxXMsQY34EiQY3xyKak6CAA40Khb2 LogBECAmdXwCutA9ePpacQkoUsPB2kYAfhgwAVybZCyNgkYMGqKMijtqAVVQtxja/cRfgJYgF/9g QDgCbAcZGYCQEgHAEGA5hwtEbQ7vmSxxbFyRcJR5IdBAQA1uAQUmVMANFajHQLoAB4ZggJs0aAcO iNAODk8EAzUQQjF6w4QasGMFuaiELnAwh1xE9iS88HBDZCGAlRekFFzIrBq4UAq/bkoXllhBO6xN EQxgIAIxiAACKBELBAjBACFIPAAuYPWTAAAT9C1IDYRhgDTsWiAFCMKih3qCIBRgIe248EhWgIPG OwQERgCzkWXBCyPYQBb2q0ENmHD2kwBDAAs5rBEiTo9/EAEOLsjAULHc1rgWRAgIyAUvmMAqp9Se ITaoAQ3mEAobbGoYBx3GMOBhcZxAYALyocT/BO7nDeoEoxiqCIDmNRqEADQeAAhYQSiS84/JT+AQ /9vICnzdKIEgKA2/YBPtEAPCcAtQMhClcACS4Ap1txAhoHYEEQF7MA0scAdl5W1E0H8FQQTUsHEA EAzC8AuWEBT/kBpO8Q9RAHEbCH4LMQdY0AM98AavcFwO0W8aSBDE8E//AA8TIEwFAQz+gBUrUGgM oQI40BA5oAcfMAs98HMTIQQQiBNMQASaUIVDQDaSYgNx8A9DoAniRAPjRRAgoAwaEQJ2oFbs4hC7 oANvoAd34F7MlAcm0AtzQIKHoQjwQEAbgQu94HcYYAMRwA70gAvrgANGwHh+1wtMICbvMRAY/zAH 7fAV/gcAaYAJJrQQu/ADFLBqC3FhwWAAOIAD0LAO6zAlmlADPOcQsCUQMRACLiMEIZBYAwEPD5UL EQANtBIBqoAaxHA2xaAL8dJtLgFLMQAlIIgJKgCAwpSKDWFvqgB7c4gKLYFzGDAMYqIJYuINeZAG IWAJm0IMehYLaSAMIZAGMTAMz8cRigANkgJ7qmAcxgEPNXYSZVYqKvANj2QJIfALwYAJCCAOAqEK hGQD7nEBoRAKj2ICIIABkOINczgM3ecSAECQNjdZihApF0ADl7gRENBbK/AbY2UJunALEIADvIAL OFADmgANHCaNAAAAqOCSLzmTL7lgN7gRAQEBADs= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/tf3 R0lGODlhXwBgAPcAANnZ2fPz89PT0+vr6/7+/re3t/Dw8Pz8/MrKytDQ0Pj4+Nvb2/b29s7Ozrq6 us/Pz9HR0c3NzcDAwPr6+svLy/T09Pv7+/Hx8e/v78jIyLi4uMPDw9LS0vn5+fX19dTU1MfHx9bW 1t3d3cTExNjY2Pf39/39/dXV1ezs7LCwsMnJyfLy8tra2uLi4ru7u7Gxse7u7u3t7eHh4bm5uePj 48bGxubm5unp6czMzLKyst/f397e3q6urrS0tKmpqZ+fn+fn57W1tdfX17a2ttzc3LOzs+rq6qOj o6+vr5iYmJWVlcHBwcXFxb+/v729vZubm6enp8LCwujo6ODg4KioqKWlpaampqqqqnt7e4CAgIaG hpqampeXl6CgoOXl5b6+vqKiouTk5J2dnaysrLy8vPv6+46Ojn5+fpOTk6SkpIqKipmZmXBwcISE hHx8fH19fY2NjWdnZ2xsbImJiYKCgm1tbYuLi25uboeHh/b39lpaWqurq3l5eZSUlJGRkXV1dU9P T56enpaWlnJycnh4eJCQkHNzc1ZWVpycnIyMjIODg2RkZFhYWK2traGhoYGBgejn6HFxcV5eXoiI iGJiYmpqav///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAALAAAAABfAGAA AAj/AC0JHEhwYIUcC4i8IBLkQRQQBgpKnEixosWLGDMOXNCmwBUEf/gUqJNlhcaTKFOqJOhliwQJ YyI9CJOGB4gZD1bq3MnTEpALHQAcIHiFDZOeSJMqXcq06YAWA4w0nUrVkgwsgwIRqco1KQMEThLk 6EpWJwkQNGyQwMHDQYOhZeNejABjIIEGCYa8KACBgNy/BQUMGLhigcAVETTw0NAX8F/BAwMAKIgB QYEiI0JEdNwVskDJFDGEiFKkQIQAnKkKQHEAhSXQFk0k0LD3AerUSgXEsNDi9eSMFhoUqH0b907P vlMeEF7bg/GVyEET8Isy+JAUBQSUML5d4wmTAicY/87AJQEECSAiyKBBJcGDDTUg1AAgocJABRSu zwih4GIHCx04NxADJujEQgo0FDBCAy0I4AMEOyyBAwYDgeAABxhKQIElQkDxSCV64PEEBCAcIggX WNCRRRUIKEKDRAxEMEMPLoQwwUQKHKEGEmsw5oMOTCgBgRA/ODAEE3BdlEAXPLBhBhZQaEHIE0rc 4QaFAj2wgAFctvDBQB5QEEEFFRywwg1+mVDBCgEQcAB1E8WoARIzsACnJRh80EMSH6hQBQ8JGCGB GEm88YQWfliQ0QQyMKCAAgxUcIEJBsSAAQMEfYClJSWwUFACdjywxBEzHPFBI2CkFAAEGYyQwg4C Uf+3WUEK1DWBoqoN9tlvAyHwBAUO4CCCE04U0UOSGnkAgBVuSIDUncfpmhxTMYTgggY5gEACQQYE wEEBrW7wQA1XFECBBgmMgIAGR2zwAQU05JGUAFLtWtABFGwQARkuJKCCAz7cSJEHDYCgwgtNIOCa RDBsEEQKEuTgSBFIGPJGDhtI4EAGLlCRwhdFAIApUtHxKtABOGyAgxAAiACDFxrYRxABLNSQgwPo AoERDDFMUJwHCzMsUBllJPUBAVA4MC1KNmTQxAsOjLADss9h9IECDdhgyQUmW1TCAyO84IILAMyK EgMwWPDBBRDoAEAPKhigAA5BfDHABUsskUAJAUz/UMIEFbQwwQHSakRCBgoMYEAJXUu0ABNBOFBA 1jwdkIgkACR2RBpgUAKIGk30AUIWXDgAhxyT3AADJAnsIAICLUixLUoLIPBFEgsQ0LhPKjSRggNR iIBrTyackMEFllRghAEDZFDDBjZAYEkHGBABgBRhAB6DAR6YYAEKI6MUAgooOBfA7JwmsIHYLpCw adVLcRB0AAvsMEIBQ2gQgRfwcxVCBwQZwQwksAAA9q8rKhjBAhZIARUcUC4jQEIGQJCBHmTggXEh QYEGMoUDdEABMWDA9mzQHwzm5gYDuYAIFAAAKpyhED9Agxm6Y0KSAUUCN2AhARhggxrIYAIKMGAN /0lmgQssAgGWWIAJdACB63FABi2IwRCRcgJMwWUKlgBDHJJQhR9YgREpmGJPcNAAIKzACCeQngEo tAKTbCAEYuQJAmoggjpGoAFxnAp/CCKCPDZFACgUCNf8yBQBsIkDQNkdIXXCAb91YTCKXKRKPnCD zXgAfZLkiQzegwAfhKE3mewJAG4QAAEIIQBYDGVBTmA2uJiAATQUSARY4IEKMCoBqizIDMSwBSWk YA08UEISHICILRRgD2PQggtO8AEaOJMEOcnlfVjwEhYUQAQg6EELAJABACCAAzP4JgV0QM4G4FGa K1GBE07AziggEZ0qCQGyYAXPlJSsnvaUFmzwqd2Re/Kzn/qM5D8DE9CBZsSfBrUIQhNKkYUyVCIO fShBIipRgVC0oheVaEYfulFJAtAEd3LO8CzR0UWKYA4/8AEaxECFNnQhBWeAwwksWlB8osBcKvAB FMiABAoEwQpVwFJJDTrUgRb1n0flZ1LxudR6NhWeT0VnVKU51VxWVZVXDWVWM7lVSXZ1kV8lZFj9 ONY8ljWOZxVjWqe4GoMIlKEUsMF0CIABDlR0IlN4AAsAsIAEbOWuBbHAAKRwgUpaAlp3DYEDIvCD HNTgB0IALEFk0AAWbAABJFCBztAZEAA7 ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/tf4 R0lGODlhXwByAPcAALq2yJWXxoiFqHVqeIhbMcrH2MS8z3d4p4R5h3yDsoeJt5mVqC4xbImEmGdW WGdZZnl2mGcwEoR7lmdHlXZmaHt0iLi31lUmEoV4pZiFdJSKmKaZlJOLp9rW53ZXnJaHtTEtUCsx hId4eGlmh2Q4jqaauGZnl7Wsxlk0iqqQc3VrhoZppldFSKmkqcjEzUc4SqSbpjRCjbq1usS7uSsT deTc6drW2TQmMZSIiNXM2aabxWVppVdIVnhiVr7B4IuDiHtyeBALa2pjeDANCLKjlFxhlndIJVRa mHpnpFZWiJuTm3lUN2ZbdXRpmLaruenl6VlWdksVB6ir1kUmg3V6sohnSG1yp2pVmklTmQMDU8nJ 5XJLmGY4IkUzdkY1N3dYRoyRumdGNnVYppuhyVQphpV2Vodzaejq+GhTS8jEuWxhaFlCOVxUZ0dJ d4VpVZJ2q3FbVrKpqWJJRkVKh52cvVhjpFM6Nfz8+kdCZ1g0JKSjxaWjvKyrxREDB5SSs5uiu1tE kpSTvTs/clZJjfTp64NrY0lBWHY/GVNLZopzWAwILq2rvEcwitjO46yks+Lc29nc80UpI4Z8sp2c slBcn5V9slY5kZV6ZGpBKKulvKukxHFKMWJdiBojdZyTvUxRiph2Rm9dY7CyzI6RqWFNUtLKyKOk tKOizpyUskgxKaCIuJ+TiWlzta6x115RVSUZJqulzs/T6TgfGK2rsrmxrK6szX9ZnW5wneDk9EIZ eZWcvkUdgYNdomVCkczW+X5RKn9rdJSbsbO55qOrxJV8mqWrzOzo27qs0ZJqqYVfSFYqIB4ZRxsf Wc7Q2I58iP/26pqBXOrx/U5BSaWGX0xPenpuaT9MltnTyZFtWVJMeLCcqJFnPW5vi4FvhWFPYV9g fY98cm1QOYFhoXFfcY9vST4tMnBMQaB8s05SbF1PSl4eBVQjjaaqtm9DknJajrGyr3FOUoFtrk83 joBeZVVpw597Utvn32VPhLOev5CPnf7w8LSfeqGLpLGxwGRurYBgPyH5BAAAAAAALAAAAABfAHIA AAj/AEl46ESDDAoyBlGQmGBrxQQUKNq1m0AiIYl2vdptaVdRXrx2ZNqJk9TLg4ddG3NZ0pRmQ4Y4 kJrFIWfEjRtwX2RhioIpg5xDS4ZgImBkCZFouDJEiWBk26EhXHBok1FgAwBIMjYZuSKJRq4pu9YZ JLOrE4mKKCaQHdvrbNspNGzxUliRhgJUFSdsoRHiTa8JsNJkUPbvXQtwysKZc/MlmbpNZg5xiUAg SpRNS35FKORyyaF/GUqlGLIU06ZCUbrN4HJhEy8GEQ9GJLErSJYpai9u6RXSFse27bIEmXClIomv qpCQ2DKFNjNA7VA4ubRkAwUuvxJF6rOJeoZfVYaR/1NHIIUbdeouHIoi69AhZUuq0DqTJsoQAnmG qIuwaciQC1EAchZCKADCCCMT4GbJFedEd9ZFHmx0liUh8bVFEGBlIY4H4ogjDyDQLWSJNsrkkcIv m1CQiDKy1EMEONC4VAE4kplRxS9coAcgaRGkcgERMbkxRAR22GcHJkPYEckFbaGwW21ZWIJCJR80 50FEGm2hUEYrrNCLQigw084UWfRCQwLnfDkBEldo+cYWHICSwTYEpDMABZKF0YMSQCSyyjRfRBFO GBGUcWMEaCSSRypr/IdNBzbYkEYVTMmizAVcYLNEHgiJdcUKQQxyBQ1vXPHXFB6UENE5EZEkDkTI 2P9CAg2MoJDFILl8gk8760TngQ5rikEMERoMsUZm4ZBTRSSpuOGKEUVx4QA0OYLixiXQ4DAnF1Bc EMEFGciASzNLqPPLU4dgo0QPUUyRSzsehNBJglnoRYMlW4hzhTi8TBHEPcjw8pcHf6lSCQq7MELD FZ8i09ZFZDBjwm7a7NODsZce4kYiYbhhxxfbQJOKHF9kQMQvRWVAQAZ5HGLEP0TZEUEVheQRxSH7 mVOFGT1MhoQ8W2BABg0HhSAwIB3KUwIGgGwRwyBI7HKWk730go84ZKyjEAaVbLELRGP2wYxe2oBC zhLJYILJEiKYIYs55hxCwDY6HVLFKtAYoU46X+D/90UZTJEDRxXb+BcByhG0UEgYm0SATXQoMJKL 1OdMwIgleq0AyAoxZHFODqpM0Q4+ZGD4wQceIMNREEFc4c5fKNAwBSAMEN2LE5soo8wh01QheM8R 7PNPFUtE0fIFFxBwyAWR2GFEBkCkIMcF2PwAM012LBGBMj2H8U8YyWCwzi4coRRhEwti4IEAHsgu xpocomJLLq2/gWoJ7eSSBUpnjZoFM1fbwgTwgaQhGGEV1TAHNKCxmE1w4R9GyEPyqnApAoDiEGEA hwjc8JlfhAEYmPhFNRJhBi5EIQxcWEIJe5CMN6ACBbk4CA12sQJxLEccE2iHLRAGiKp5YGiSGJUY /5BBgyxEpBNZIMsUrsAIeTAgCPHwxAq2wI/8DEEZodhEHhJRhnTk4Rc3W5YRaEGOCAwhD+T4xRJw MA0jRMEIsoCKGsMgCwTgAA1fINIXzLGEHtDwDTQIAg1oEI8VCAQFsiKB5HIBCF5wBDfx4MUygoCP N2SBBhsKQi70Z4JBMAIZEEFBW2DRgz7IYmb/2AYmjJAIO0CjcUHhwjQ2QQATVsE9RiiDES6ACXXI 4gLqqEIK7ACPDeRhd/65BBwGEBFbbEEeOhSgBzyhryshrQtZyEJ0ADGIQVgiF31ggAFQEARxvEEc nZBHIK/ggYccpFcnCAdQeJedH7DgAj+QQB5+Kf8LI9TyH8ckAH9+4cEL5LJcXPjbErgQDkwFJRIF IEIZMIICgTVxCowggyWQ8IYSkOANqjgHJ5bxJXEMQhL9sMT/INCFAZGAYbbohTwkEY9eIKNNYjiB G2SRh8lgIxHbWEP2osAiXv6CAL2UWzgwcYFfgKIHcCAAQTfgBgLQUVkXSMUl7NCNR5wnh7zYwl4u 6QG/2AIJ0dnFLnpxBTJ4QCQHy0QlAKGDNihCHMhYRxaS8AZ5xNQSmptCISegjV/4pw+HAAcXCOBA y5RhSauEhmfUWMYrMjYVSzBbGpSnE3JMww5rUCMREsEFIxjEaxNAxhbcKg4adKEfaumFLSYwSKD/ IQNUQVCFCwDgrxXYwhINkIEk+rcCS7DuL/E4AQHUwdRkmEGq8enJJQx6iJ5+4R1uCJkb80AodUSi Gj2IAFMjEI7JJMNmmApDFYzAC0DYxrVT2pAllhEPJDBiC2+wxDpIYJsuADIIW3BHJ8hAghreown4 QII1OWA5gwBigNNYwjYcsAZo9OAL0CjDNlaBJCPUYw1RqEIwlkCUf4jgCzbCmTJYQwBZJGsTkeAC JsJBVDcs4QK8mIA8/ucvYnhpBZVYCIgwxJF1TKEL7QCE0QYJEVsgowvlxIAlcPMlMmTBBOJgRMXM sARMcGEb1YCDP83oywgkAhMRyMCFG7CGcKSN/wjpEK8yjhqBPuRBK0bogxHCkAebYOIQ+dqCJXpx DjFMQRx0EEcJPGCLSsRDEJNjRAkElgvaTGACIB3kcUzgASRMoMooWAYzPnAFQHQjBTaIg48usAog JMMNFIyArBebh3AsIRw8G08evhAOlV0gEYdQGzDFi6kv9EAWstiGEVTxAYRYog2AIIMtmgGGCfSw a1tA4iDw0QtGiO5Cu7iCLQRxyXbYYBAAdiZHriAGZnRiC8QABTaCigk7oKEQLYBGHvKwDS5g5xfq iEIPlmCECBA8CnKgj2W0lwxQhKNxwuzBD8Jh53psYjdT+GYn7kEwJIhjC/1oAhl28+CY9uokH/9w wSBmRYMJpG5DvCDLB8TRi48HgQqV0EYK7FMojqUjBdD4TxnKy9jHpA0ca5B1FFyQBnUogwJm+EIh 5EYAAqyCCD1wwz9kndV28ELBHviAr06SixI0mwSytUXpNvlRDwh3BV2gAS+uAAIyAMIdKJCHgj/w l48jwQnkQIMB3VANImzACJu4QA+mIVWXJaLLSyCHQIc0DS7IYgP7wEQYCH4IgsoBE/9AureG4A0U lFUvy8EHKgS4i69MkS62SMIustmED6DAtyhYxw7/RwNBVKLmgJjCFMgwgV2IgYyrmMc/JL6BafwC DYz7IhijQAAK/FkZVzRhBA6xBq0boRoFT6H/v39xCTPA+hDmAMC7dkgrQCh4BVfoVxB2cAIYJrFy IWBGECTxBvhXZBdksAxNhAEAsDBJkAVi4WnxcAy/AA5wEAWRADLk0HDhQBr+BAd5sH3AxAU28w9c RgDKkDdLkAE8Yw6/gAmXQA6SIQL/EAXw4AIh4DXtwAjhBggL4wHCdzlO8AHZNAgroBELck7xIA9k QCYF8QEWgAeCwAgJ8AMIGASfkF/E8AuXYgfAtGHgkAIPqAxMsQ1L8BP1BnAXoAELJC3/gAlugAM4 AA5clwhVoA52EF5DEAbQ0A5v4AEucAJuhQEYtQedAGAGYCoJMwkrYCtBcAJthTWREwS1MgH2/9AE QdALSGBoE5ALncALZ1IPUcAFSpAM2wcNifBwv/ADgUKFdnAIZbB1h+AMtJAIrZQIIgAHcJAZEUBU XbZLKKMZ+/EuJSAADIAMmmA5g1ACtsA6JzAIWYAExaUwNGACAsAIl3QOttAcosQI/eABudBtvbAO SCAAU7CNJXAIEbABpWAAcjAkMrZiPUAA//AFmrE93pIB+8AF1aAEZjA81fBnlnEI5FBGaoMdBKAe F3AFpmcrjGAKqrBjYqAKtnEPNBADd8gwBwFSH9AJXaA+CJMFgtAGliAOSPBgCrYFVxAP95AFsJAC RDAuuKAElvEfAKIMYfAFpSWO5sBUN3AIkf8QChnQOL/QA1a4iXZwVOpgDhwADojQUMhjC+LgLh4Q BE0gCROgSR5AB0fwISvwfh8QD1MgVr0QD42wBYzAflMwB6JDMHn3EJbwAe5lAU/QAc1QAB3QApuA DfAgC41jBOFgcOHAXKDwA4YgCyWTAUYgFM5nH0OQCrszNxLQAD1wC4XgHxdAA+5gBVFiCRhwaZXw Ide4C/JAkOcgQLJVHIT0Du4QUxMgDusQNJOzBZqjPwxiEgDwBDBABABABC2QDI8QCzNQFawhAusS BW4wAEAAB/+gBN+BcJdgeVAQZpHgGT3XGtRiSmGQBXhwDLUxBefQJaQWD8uwDGKwOYDQBWT/kgsd QgLroAfM0Afu8GmVQFvi8EQo0AQfmQRT8Ak1ZQCPAAMyYAAwsAEy0AEu0AzRUABRAAerkHS8BgTf sQoykAjkYAeJQC1yAAPvoAR2CSA4IgvApg59wAPY8BdaknGFJEBv8AafYAUb0Q7y0An+Ig+7sDAe mQWKUASeUGnYSAOf4BUcdQVvkAvMcAW5YADRcAbNkAYt0QwuYADN0Awt6G9DsgENsGHcADIZ4Ap2 kJxzRgA4gAA8IAt90AfqEAYZwwV9sARLMCZBQAJbqSUmER0gZRsU0Qsf8AYTgERTgASWEEio4xVe pwiH1haMIAZoZwmAsA5O8CLagw1vOQPN/xALS7AJX+Bdb3RmCYUAhRABIkAyGeAfkqEGQAAG+eCl kSBr6sCBF5AYgkYDJIBEqjogHGILO9AJflAJu4AMfiEPIXAEL8Um+nIgakoQ/SejkqBgJPBgMNAf 6jAEm2AMsRALkJAIEbAKStEHa9AD/eZldiMCavAPkSdUcLBHYbAGA1BA3hIBKdRLXLAFYiAluxAC 8gAWk3N7byBFbyAJeXppSFAJGFASTEQcZ6FOSyRWbVA/SPAXjOAJVXAzFzAkKTAD5yFjXyANfaBV 2CCL2/cLGcADX7AJ5pAI8wAH4KANSoAJppQjyMNL2qMMcLARWvJJlVBq8iAPtxcPMbULqP/wM7sR IaqwA2tCK/EAZQKxEWqBDPqyBblAA4KmB5egDHozBOMAD6fKBakwBPAwBmwQBclQDjdQBUIwdfkg AHz2BfvQAHJABLHQAcnASxfgiVxwCHBgDskQCXIwObbwQyHBaFbWcrcnCQYhDvGQFi+6RG11JnsQ SIO0Dl/xrrlAhDSgCEFgCfyAMwEHD8HwAKSxH7JQB2NgDuogAoiQB+pAAT8gBxUQCv6xFBdgBk5g AHFwslEwDg9gQgEHDgH3ASWAD8cQUuegCvhQCVhgBfx3DDXwAZWgCiegCrCAD3WwgDogDgFwBycQ D5VwW2+wu70bDzqgA6rQBHUgCQYwDdP/kAIoKVEpwAE4IL4zQAtukAEugJIpsAraAAMusA8ZIALY YDLX8AjXMAPNlwwa4APtewnYgJLYcAnN0JajgA4tcAYAsAAyYAwy0A8xoQGuUA2m4AMFAABKsAql EAcbgANwsAgyMAOzoAQ4MAvN4APFMAxaoABAsAoA4AQyQAhn0Apa4AsWMAOi4AQt4AIFYAEQoAQk DLIagAvRUAob8AMAcAJ7oAEa8A0QIANxEJsJoAA1sAAG4Au+oAWxoAOn0AgWIAoLIAEgIA0NcADf IAEzMAl/AACmUA6yIA0D8AeT8AMIIA3fsAAOYAfpUAH50AJAwCgIIAFHUAcHAAV9cANM/yAAEoAB BdAKRcANY3AEPGACeOAMA+AFPCAHIJAFiGAHcPClIFAEMzAAzuAM0jAEr6AITaAFErAGLNAJkgAA OCABAfABEPABHMABsCAKViABBSAKFfANdZAAbWwKLhAMdcANPzALOOCbujAJDoAHbOCpCZAAFJAG pcANJlAMC+AFLyAB1WAGDuANQvACnHAGsXAK/aAJgmAIA2AC15wEFWAGocAMIyAC49ADkaAI0gAJ CAAMpDCx5ucMCFACGiABTWACIYAFQjACu8wBsdAIOiAKMYAF3JAOSkAJdaAAAjALs/AH1hADEqAE PyACOBAHgOwAsrAGPzAJYDAKIuAC7P/QCTHgD0IgB2vgBQ2wB0IABdW8BzVwCovJASrQAEKwCgHQ CQogDBygBGwgCAjgDRywCjsVCV7aB5HgCjfAAl5gB6bgCwCgDSAQBKwQAkHgAtHwBJoQCzBgAcOQ AJRQDQdgDcGgC6OQD7MABtbwDamQDgjwDd+QBjiQCnwMBAjgAC2wChqwCJQQAxAwAukwCv4gDXaQ BNwgBAtQDCMAAHSgAjEg1WygAcBQDeGsAQ/gDXoABQsACQ2QCQ5wAS0tC6sAAWAAACqgAgYACacw AEzADQXgAzvACT9gAH8wAmwgDRbAB8MQAGBw0+8QDAlwANUABOmwCtLQx+gwAj+wBmj/sAbp0AZe IAssgAAAQAVgEAfVkA520ABQwA0OwAYNIAEV4N7BwAQvIAhNIAMgQA0jIAQDAA5KwAAMkAGOYAG+ IAxAwAI3gAMFoAa0YAV1AAMD4AQWUAGG0AoWYAMAIAG10AIU4A2vgAjSIA39YAC68AejMArSbcxs kAosYAY/4AVqULnVoAYi8Ajc8AoIkArSEAwAwA5AAA44wNJqMABqkA8/4AojoAsQ4Act0AIg8AJm bAIvgAcVEAPL4AAVIAS34A1qIAU+4AMIgA6f8ASjwAIsUA4S0A0IkAAS4A0DsAd+UAAs8AI8EAqL wATj0AhxYAiOYA8BIAH5AAC6EAzD/zAJ1TACUKAErtAH3GAK6bAGa6AGfhkMq5AKSpxq6VAO7O0K QFANdqAGSvANWFABKgABDWABof0C5YAHRE4NgvAFQhAC6AAHCDACpwAJvmAKNyALFLAGcpDKZnAE ARAAwVADLkABN2AI+SACsmAIivAKJdAMYaAINnAHWlABCLAAd80OpqAE7PAOQFAOXjAKGixxPwAH aPAOhvANMmADj5AP1OAFa3DjD/AKfcACIyABDjAE0pAAYGAB1hACDPANDYDeDIAAM4ALlMAMLaAG atAAreADdIAGnroIoUALSmAIASAIhSACniAFXjAEDjAAPBAJWdAJDaAHhlAO2fAARP9QA5PwAGoA A8NgCsFwAD8QDBXQx6KQDzigBDQNA/LNDfngAiIQ5UJQDWpYDV6aDl76A2pgCIJQBHLQAlTwCoZA B90QBG2gBt7AAtyA2AWgBHCgAVBQDBLABA8wDj9wA+igBsyQDy/wAoYABQIQCn3gBcCgBTDwCa2Q CSMAAhBQACNAARqAAMHw0jAwCuwwDCbgDxAgAoguAD8ABAOwACbNDeywAes9AkCwATBQDTxwA+Xw AxLLA/kwAP5ACegwBPmQADfAAxVQDkPw8omsCCMADopgCK/gAFsKA5n/BeWwDK+gARBgBqjgBw3u CAewDIqAB1JQADJgChKQCV0wAh3/4ANgwAGmwAecLwCjYNLvMAzoEAyiAADvkNlqgAPscOP5gACh 0AAj4Arg4AXpwAKvABBqHLxi40ANm3IQBDQYxqZIEhFCzMBJxSISHERyHogwpKgbDiEiRLCQNqRa swEsGkAKxQSWhSLL+mTTQAqRhFDMwOBL4K9RKzr9TJkaxq1Pj2FtGgR710INNQjvYFSTpibfu1EH NqiBY8dLPiB9ICxKl87LCwHFPPkR8aeJDVxsIrkCMuJFH1lARKBZ1k3Jsld9FAUZwgKNnRsbaLWB ggFMtS89OOR7ACGOrBG4+PCxkMBEsEl+KmR9hadOTwg/EIg40AABtxYNhJgCEIxK/7BEcG4AGebF C5gfXoBISCBq2Ld+FiDsmYQAQQUEQBjILAeiT6pwcCik6uPllaJla76weRUKHCIBKlzxKKJnkQUD e3CIKKAFUiNRUPvBuPUNAjsIKBkmjW8OyKeCCt5hhxt0XAFHCSC8+GYEOFhIZxQcyvFilD8c4GEY MPwxAYojfDAgkHGAecAOUszAoQIgQGADBwdSkaOcSNCAQw1ZXuHEiQwUwQOXd5jZIxUHOOgEBE0g 6UcCPzrQohZHLOBgAwAWmaQFF3R5px920hjlmx+CaYGbYGR45wc7hMinj1dE8KIPEXTxzotJ/ril HCES0IWbG0ZwQgYKVFhyHiU0cP/AAR8aFSCOYgRhQRYznFJiADNmmC8dVPRooIgGZBFADzv6YEMJ BFRgA0owYADACggAYAeAWRZoAQcgfvhBjWDUAAKrYB6AI59gRgHClVHUeMUVFniQZbZ8/hiFDYV+ QIcJHASYwYkDYrhBlh/8kEADIITwwRcDjmCmENXUCAMOR2JRgoFOSGlALRhcWITcNfrwtwIAHoCi CRMs4GaHT4TAwRREHMDhByF+mOGdYNLJR5cGqvH3hgPV0KCBV27AQZo+ch1AguYSCAaBUSwIpgIm ZvGhFWcKweEFFijQgAIKGtAlnwVU6IEFVx6QRZYHBHGBmRCeuKMZJTIRpQc7QrH/CQizMgEAAU4c oEAAFuAIRY1AKkhnjWoayKcZLUwpYBFuuBHCX3CNpaCPcvIRwBAHFuCOGxjUqEDvBPJRQ4104rgD glcKwSUTJjggZQ2evQjbjWxeWcMMhLzAgxRZVnlklRte0QaHGzp5hYI4olbjAWCAEeKANVDxwpxv 6ugHgHKGqECUfhpQo5oWFsBBBh/mVAMBKCAsB9w/cOYm5GA0+EYCU0aZwxAWJEgFBwtAGIICBTho gAoRgOAhkh7kkIaaEVSIhHglcEmhuzTuuk6WPAzJ4hU7IAAHdsBANYagAg0EAgMlEIEGEjAKkUjD AcEIBg7UsIZ0qEFXaQADN15Q/5pguMAUpVLDLKqRDgg4YHAUwIMVRsEhISAiQo5AwghC4QAgHIAJ IICCNoTgADuwwAFQMEQ44FEMPzzHDIogxVMmsQggsKAC/XBFjaAggXJwIAMgiAEdVsGEEzgDAgqw wmxmEIwicAMIa3BANUTwgwa8Ix1AcEE6EOADU/xAFsLZgCtAMAxT+MoB3BhFHf6ghBG0oQ8UqMEY kjCOBjhDAswwhBrZ4AxgqAENX4gECOYADhwoAgTfoMYGEHCGJ4iADfSQQCJw8IAKeGEZCxnHEWKw kXGUoAESOIAA8jEJGQyjAbNQAg8gcABT9KMZOOiDGnwAvAec0FdAWMUyPlGMBv88oGjssI0f8pFH EBgCAMTwgx8eoYVxCIITIkgFCDiBA9ClYwkgoCcIXsCDVAAhlbOwQzj4w4MoeKMEUFrEgcBQgh9o AwIYIEZ0GhC8HySAG6WIRQuCMYw/mIId/RDAN8CSDyLmAwJKaMBwMjqKCgygAQIIhgn8MQYJyKIP 8YNBI8BgBQNwQAn+YEAPQvECIHQDGGF4QBu64QxBvIAUobADMKrRDQHI4gUPCIMiFDGKM+BAAqIQ wgA4UAE4aOAUexABMGCghBagYhTWGMUj2HEAGbhgFC6YARDywQ41SAMP6GAHKwSgqx9YYBZAUFsF hnGAb9xCZcHwIzcaYINTsEL/D6gIhDAOwANwoEJYPACBA+BwAD9AwAzeCME3nJHNH6jgByZQBBqC kQBwuIECUPCGxwQABKkSoxH8OAEx4KAEUVhgD6IYxQ9a049gCAAMD0gFDBbQgB+0QBQJgGM+MtEC BDTgD2BaBAKEMAoADEMUPmAHEAZQiiKEQBPFkAAHFiCAMfjBFWggxTKogQracmMEiOgEBDJhkR/A QgZw8IIBCvAIKPSBBaZAAwuyEIAnxIJ0OCjBBoDxsbsWwBSsOABGW0BSlEqDHezIh64AsIABEPYH A1DBAgwAgHyIoAiU0EUCwCAKAEAAHbF6RCt00AFUCCGT4+DAiuRAhTqwAgTN/zIEDNhwgwwgYAiR EMEX+iCHDlQjD4pggAwk8IIeGcYZX3hFF/gxAhE4o3tUoMUkRjEGU7QgAQ3AgRLCeyw1UGAoGhAC jIqGgGAsQhQSEMIIWDGM0/hAA9SgQjpkAIkPPKEVgfBBBZzRgwqowBuhWMUAZEGcHohAAZ8oRxbG AA47vMAbOhCACGSBIxFsgBmsoMUPpHGD55WaHzoIRc6EAQEYTGIBi5DAKhKQACDAQDmvKAcL1LCH BpxsFKt56B/cPAA2iKACJnBBLGDQvVa8IBNa6EYBqNAJWIAhFNXIMzigkA05KOIbVBgpBJSChXIw gQGhkIIPQtGHISBgEXYoB/8DeJABA+ACBhSQxQ28AAxtCKAcdsABBwSwgPaqRgCmyIcS/gACLxjC EJOAMaEb4IpviEIAlGjAyV/hQggUoBnpeIEGuAEGSBgAA3NQQAACgAFF9MFDFLBCJw7AjBc0QBhf pkAFMrCGF4BAGkAolSIc4IUe9AARoWg4DGhBAW+QggkWgIMT8PGAcXiBAwEAgwA0kFJfQsAAB1jG D0DADUj8oA0QGAAa2GDji07CAiqAQivY4YN+IEIISnCFCZxAi25IoA4fIAIOWkAFDASAEklAgBX4 IAwLGK8aisiGIJahAXA0QAOyiEI5NGeHIZRDDs64tQPGoYEFUAACVJgHByD/QIwGcMAPdPCDBmDw h3wMYwzf6AEbvMANPDTDGDfAAzV4gIhR8GEUdHDBHsAABhdIiw+3+AQYeikKGLQAHx1oBjCyYQgc 1KAYCvBDtFmhAB9o4QFD8AIniq0IV/iBB7CaHliDNfCG/TOEFkMABvACCoAEIkAAJrgCc/A+DBgB HdAECFABF5CBExCFVtAFB2i2ahiBPbgDcOiDBxgBARAA5hCAYVCuYzuAHViAm5sEAXggGOAAA9CC ExgAQ9gBSsCDBXCCTNCFUECADqIDNkCaXkKAF7ADWUAADeiGB5iDBoAAHuiD08OBOMiAcsiDSAAG RHiBUMAkbQAADDgAWHCE/yzMkgX4BlSQBkQ4gHQIwA6Igz64gWqYhEzgg3zgAD2gAn+wOSugggTg AOaIASrIAT0QAEmwgA44AQmAghG4BRAAgyPwgwXwBgnAgHGZnG5AhVDggU54AG9wuwMUhDaYAxUQ AgP4glRIhSFgo1I5RSskhhXQAFTgABUYgFnQhGwAgwpgg0K4gR3QAw85gDqogHLIIlEoAjrIhECg gxPwAWmAgjHohwWwAvNRgDqwggCQhCYoAIMxhOoTBB4QgTlIgl1SAQnoBrEhBS9wBmKQABVwRkUI hTyggEJIghCAASLIAC+IhGUAgTWQAziIBDt4AAzAACroBg3wBAhwSE3wAf8IkAQOgIIhsINiWAC5 k4IEGIA+QAQLoIMEoAM6kA0BOAE/kARNOMkEOIBejAFWkAIBgIInCIBlyAZKuIU2eIGkQ4Vx8IZx YIEXiILSK4QmUIBWkABgaANmQIR5+MVuYIAbILgPYKZlQAw7sAM5QMASWIFXIAZVAMUS4IB+gAVn w4MbUAFHUAFPwAUAcIVXMLhQOIECCIRAUIFyMAEdEIUduAUroD9WsIZPMIQRGAAMaIIWEIA5YABO OAIGEAxD6IYy9AbCYwEGOAJtoEwBoIID8AQpUAEVGIcbgLohWE1mk6khUIZyeAFBkIUhkANw+AAD OAEnaIQaoCsYgINVUIL/H3gxLagBKUEgHwACVICEWNCCDhAFDhiv8bIxHyiAWgCDPwgFChiAQGgF PXAEKaiA9pIAblADbgAAGICBTJjEDdCAOJABJxABRxCGWsgBR9QGDTCDQjADYAiFBnCAjQgbM1iF EUgCKHgAZ+iAWLCAGtCCAAgEAQCAAnABH5ACGygAXXABC2iFWWiGGtCDWHgEADAAFxiGVoCEZhC0 TCiGZsiBAgDBAigGKeiAYfABQqCFDmSHMXCBZiDRHDAAJ8iXGZgEJ4iDfvCBGcBRAKCFFmgBkrMB GXCEdzCAWCgA+2ROBZgE+4QPFygAMMACPVCAThhTSqCCHQgBSgADSii9/zr4hD4AgRwQACxogwG4 S2vYAToQAD+YA6MzAQEwgTkoAlZogk6QBEONgx+AADbAA0H4UyZQA0TgAYF4gHIghXF4gU5gBkiS nAEYBx7AAyEQBAZggnFgAiZQAQyohG5oghgAgXjwBEhEAgU4yTEYA1aIgTqwhizoBErQAzCoAwjg gFqIgT5ggEYghMiMKRC4BTUQgFsQAoXQBhMIgVsIgQPIgWP4hAQoAR7QABPIBgiAAASAgHFgAyhQ qQLABXxSgkKAAizANg3QABbgRQRQAm7IgjZwhnyEx0yDAH5AhW7IBmuQBAzohjqIgQOwgO/ThToI gU8YBgsYBj8wAQjgA/9W+AQRCIEEcAFuuAUo6JkFcAZY2CGME4KdYwBqSIBjQAXCPABD4IM2ANU/ q4AREAQT7IAxoIRFkIZCcAZvgAIVoACxQYBuoIASwIBGBQIHkAABAD4VkASM+1YGEIQm6AYqwAJr SIBAoAJdsAIAqIFmoAMwSAAr8CZFEARRmIRPQAVToIYu0wM/YA4KuAGFmINAfYFboINPuIVWcAQT OIUOEAI7iARZcAABQIA7yI8BUABKsIKdDYUzHIMGCAUggFxncAYE4ICPaQAKAIZvOAINOCbXkABx dQUM+AAs2NoYUACxHQNRoAJrOAAwyNpggIJX+AQqKIBR8LxseIF80AT/Pdi2NBgAKNAEK8CCCnCE b+CGCK2BGcADBUgDIGCDByAFFoCAP/CBBLhVMFiNb6CAUICD4CKGG4IDYFgIChgHKuwG6FrU9gIC JpAAVBCAI0iCT+CEILCCBAgB/QUDXfgDMDCBP0gAhKUEztqBYKCDYPADSvyBIjgA6OSAQEiAbxAA HbiFQIiDVGCAQDAAP6ACaggBPVixNuAEV0AABaCHGGAAt0ODRXDGdBgAIQhfYBABOHCGIuAERIKC M8NCYPgBCeCEB+gGFQhWE2AaP7hTvgSDEKgDKohJKhiGGIiBfjiCBjCFHTCFA5iD8lvgJgYAa5yD GIAAJtCDW4jeUKhg/yuIASwogk7QBQ3QNBYIG4mCgqJBuSIwhD4whxcoh/TJXGf4gVFwrzjGgwH4 BDXwBk+AgRdABBXoBjY4Ag6ghjqABX84AB14ghI1PzAYg0u2gj84AJzqBwUQgD+wgjkAgByYVjrY AwlYAD8AAAHIBj+wgUwwAG0oAlid4gQ4BReQYWAAIjQQAh4YADWYKmkAgSBIheaToej4AQ5QAwkY hXFZgASghl9EgCSYAyaIzVSx2SYoAgnQA609hkawgTHQgRxghzkQgGcohRhogxmQgG+Yg0Xgg0Uw hh/thwPoJQm4BT+4hSIY0QMon07YgRzAgKxthFJgARBgACGgAM6MOv8QqIarW4MH+AERyIcGgJFq WIMBoABXUINu4AB+gIJ9g4NxuAVqGABEyAZnKFAoFIQPEAUFSIAcqAED4AMSBQBu6AddwIJbUAI2 WAaHAIMceAQhAJcdWAQAEOhJCIYYCIJA8IMDcIED2GY60AclsAZWKIEeGAE8qAD8CgGEFEM0yDNp CAFuUAKMy0Y1cAYYUA0gQAA44AFvGIBQiISjai8V8IJxGAEWsANU9QQztc8EOAETyAd9eARb3oEE cAK8kAFdiAFReIYtfIEYSAAbcFYXMIYR6IQiEABNeBUIoNo9gIBqBQMlKFhIUgF6RIcHkAPzqgZE UIp4pQA2+IYG6Ib/EZCAH6jcHkCDNQACCiBuBwAGKLgFpgoFT3QAENADSrCGWuCDEBCAJAAAY+AD AOgHK+iHOViGk9BEbkgDARiBBkgCK3ABA4AAJ8iBYuEGVHiEIoiBW3gB/+MEKjgCPiCGARgAUqgA 5loDSa2G7eQBbsCBljNm53CGbwCBmn2Ob0gJypUAZrk6axAAeCAFbyAGUgCBAGDc9cOCqzaGR9CF QKiDOZABrx4GoY5DHngABGDYDp6BfAhUGszBSSDbEMCCBNgDWQgBC8iBboBkUvhvCrigUBgAYOAB KBAFRyDrlAICwpIACcC2FkSHw3kdVxiHFCOFFxgBKOCBNRiBotSE/1M4gBMgBHM7gp3eAQXwcSFY gGYYAyzIhxzgAwGgABEYABCIOQPoB0GAgj3Agk+IgSOQAEfQBTBoBZLEAh9wgabyBjkQnJSQBTmo BgkQBGqQgpUBgmpAAGCIDiaIgT6rAwlwADuSADkYAlfANrc0SDOsSERQAGv4ADZHyayNgR0ogAQo BQRuBm5wtDuQgTZQAk34hpDjgOTSBGMQgCLwAyy4rZbsDEEIQh1ogUgoSjlAAwoghVd4BYXcvR0w dARYlGAOX1JIggHgBigAgWVwBqW1gy+gACFogwfwAg1BRWB4aCwIgROogUCwAjDoBzD4hFm4hhdT ADDw6QEwBmMoAv9F0AkqCABUWN5AINIiwAIXeAITSIIC8INAoIYgMAEMgAVtWAMoELJFIQVX+KEe UAIFqAAogACl9RoHQJsfJoYKoAAQ+IRLQYNQSIIKCAUh2DceeIE1KIfre4E6OIBjoD9YCARUMIBJ KAIr0ANd4AN/AAAbqIFnsIFPYAZBuAXiuj7HowNUkIEcoIUZgABmsGZWCIY5oAIAGAMAcAYMQIBv EIRxcAA0iGkogA7oqAY2kIbjtpBQiGENINp2BwIO4AREYAA083MQCIdIuD5D2E4r0IECUIAkUAD3 AAA9QEl2uIUjAJE/aAFaKAIGGAAcpD9/UUQDyIFScAEBqLtUeAH/rYX2YoABTqgFBnAAYvAGL+i1 dBCBEWAANlC9YxkAOVgDNZicdAjLEcizw3CAfKCETkAECmDfbOKsVPCGrgoFSVDnRsCCI6gFOjiA QLBpP0iAItiDOlAACQiLOaiAIziAEAAICN8M/fF0wEYpP7oY9HlVJAAGbgossFDko44KDAzgsJCz Bk01BEAoLFAzDggcNSrUwHHgwBuEEa7GkVpDCoggQSLWPOCAgMcNO3a8kJKjwFOORx2OBRI0gs4t BaPAJKgTaBaTfEwgHIkh4JuAAAn83JrzKFgnBRrSvTrgx1ARAAIGgAhQwFMnQRqAEavAwlAFCmsG AEFQwVWFfGog/wwgDGTAg2oSXNlx4OqFHVIDhECAI+fBAxYDxn2gYkEfoQIhsiipZQUVOzBRa416 IA2DlVuLwFCZJOAIBD+BFh2gRIebknK3ODCwdksTrAN0+BXBUgKYBCzfQiH6FhgOEAc8HIwU1EYN MBUO0DxAIAGyms/ShDSAoGKzIXhrInmLdwyAJjUUE4MJC9SigACmGJAPAgJgcQMIYBRjgh911EGH AgkUCMYnc+iBygi3tCGAADFg4U8jTMnQDQZNMODNCIKUE84AnUARmBxyyOKAGjx8I8QDDoSihjSk qCDSAAiQ4gA3CIgABANWSFDOCy/cUE4TANRwTA2iKHCCKLooAP+DArqM8oo0EICQRACTYACGNVZo wIEfCgihRnF7CJAPJYJIQ8UORyiwAQuBAAAHMZLgIQgIX6BhDjdJfNOAEHak40U3hlHQjQRqOMCA IECoAYQJSVATQ2M5ISLEEUeogEgRxJDyQQ4A6KBJJgocAAsVB5xAFRuKGCKBBAoocMsewXDSjwYj KFAMD68EMsoto3B1wAu3gGGCD87gQYwj8wzAATHjvCDNC97ggEADDTgAjCuhNBAeYXBEgi59A1Bg QhFsCBKKA1jEwMAXeAQxRwMHNKGCASeEEIIfkiiQiQkhKOAIB7pggMACCFKhSwJWHMCGAaMkcEIg IyDihwAJCCD/wQEOQqDHAZ+0osQDJeiAQShMdAOMIMwIEqQDS4biCscVpBOGAyBIA8wAEnBQgQoN IHALAuJp4K4047Th1QEhmNAFE9ZIYkAdClDBgAopQ7CHBR2MoUcBulByxFh1MhDAAlGN4gcEgiQw SSBJfCJAIGEbgEASBhCDQTfExJBEAyAwwwYF6wlJQQOc8JCHA2zEIAQCHJAoASoccMMACBJUoEY3 jb0uAQYxdFLEFXN4kqIOVsQQswAjHADGIjYU4IINNVCTTQGiuMCDIAiY0MoCxApAhYPWMJCAHt8M UEAOniRQADzwEHNKAv4QMwILPMoRyQOuoIFOEH3IIkQFQLzc/8BcHPiEwAvw8DIhjKMxI6gAGz4R gxDsShU52MEBdJAACHAAAreAQCAasAwJ6KMAHZiFFxpggQKw4RULuAEbnDGAWwigBC5IwBwoIZ0A qMAQtwCAFaiQg3OoYB7jcMQxKqABFXTDG0QJBQvQYIgrLYMHQkRFKD4iBKmpgBoDIIYJIICKCjCg DaQYxy0EhgVPFEEHnqhDPI6giWhVwAeNqMHq+kGIHJwAAlY4hQX0wIw2BMA2shCbH+hgDT5AYAfG wkA2OhEof7gRAm3AAzBuIIuOIAAVUhuAHVjAAzVQADISEMABEAGCF7BgHBLgRgjacJ8HgKAIDcAD HrrBhAdIIP8bIaACEmLwAU14ggonaIIiiPEE59XAAJl4QhGKcAoqBEIBRXCFIKggitURiA8GgIUL KBECSgSADS/YQQJ2IAkYOMEanehENgzxCll4YQAV6IYz7JAKFiBiJa5QQ7sMwQxmDIBTmrBCEoCx Bm98YxnlCMUAeGAIJqhABSbAgiTikQRVfEAHktBEBZigA1H4gAoI6AAYchACK9RgDCVIAAjWgAUq HEMPCeDELRJQghMYwATWYIUWhPACOhTBChB4wR5UMYgduKMb3fjGByTBiSDJIhKeMVIFxrEGlzyA ahgkFgLkIA0JNEEaQ2CBBDjBjGxgoBN1wAcSdKCKJuhgBzH/gIAzDCCMHbQrCfywwBMCcQQb3EEB 1sBDOSQwCQMIoAgCWMABqKCDBYSgCJ6ABRhuYAJJYOEInQiEDuYBDE90YxyGvU8FBuCNB3iDBZHo BgeYUEpPIOABn5BAN9jQWZiMoBuBYMI4dnCLA2CgkAeoQBPAIA9iZKgOTCBEBzhQC1g4cQcWuAMY YiAJbSggBlboBnBFdgQ6CEBkBTiAFUwQAyq0ApYKoAQlrHCMY4jjAapoaGdB09BASEIIKthKKMbh CVRQYwQSYIIQvOEN12GgAhUwwS1OoVcTQCEbn7BCE0KwA0/MQRUB+AAzltEISGABAzXwQQkkEYgT 0MECCcjC/whggYVTHCAIdfBBB/TwgRx+9wN6PcIpTDCH3Ci2BrB4AzGOEIR7hEIIC3sAEyLIARUI gAl2kAAripCEJGCBE5tpwmQF4A5g7IAKChiDJCBgCLNCEAs7eEMRznaFLOwgBx0wQAICoQU8QIAK QYhBAXyAgRFQwTpWOIIotnQ9HRTgGIhogxRKMIcJ6wAWGDhFARqhikoQI5exUwEEflrAB3RDPd7o hieqTIw5YEECKuCENY7gCSQIoIKSSACYTTBUUn/AE5WoRCNSxIkmBOIDb/SBARTQCWrUIQb+0MQx DHAMHZhAGgjAozYYYEgOYGAHN2AGLPCxgx0k4RSN8MQHjqbRCHzgYxDe4Ec8mMAEb8xDBdkQ8DjG 8YBx8CCWwMADMx5AjCZYQxBwCNsOBIaBW9yiCfEIBAaOQIWkBiIHhDgGWiuxAyvk4I01sFAgEhAy M3q7uq8gjQ5UEAJPSKIJeKhyEpBgBXAzAAPBjockGmEAVVzhHvFWgTikoQw2WAMR3UAEA5DQjS6E wMlMwII7IpwNadwgHtvmdtLdYQIrxMMKV0h1RQMCADs= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.basic.css BODY { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #333; PADDING-TOP: 0px; BACKGROUND-COLOR: #fff } H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #f90; PADDING-TOP: 0px; FONT-FAMILY: geneva, arial, = helvetica, sans-serif } H1 { FONT-SIZE: 75% } H2 { FONT-SIZE: 110% } H3 { FONT-SIZE: 105% } H4 { FONT-SIZE: 80% } H5 { FONT-SIZE: 85% } H6 { FONT-SIZE: 72% } H5 { COLOR: #333 } H6 { COLOR: #333 } P { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DT { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } DD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .txt { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } LI LI { FONT-SIZE: 100% } P { MARGIN-TOP: 0em } DL { =09 } OL { =09 } UL { =09 } A { COLOR: #369 } A:link { COLOR: #369 } A:active { COLOR: #369 } A:hover { COLOR: #369 } A:visited { COLOR: #369 } FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } FIELDSET { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; BORDER-TOP-STYLE: none! = important; PADDING-TOP: 0px! important; BORDER-RIGHT-STYLE: none! = important; BORDER-LEFT-STYLE: none! important; BORDER-BOTTOM-STYLE: = none! important } LEGEND { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } SELECT { =09 } OPTION { =09 } INPUT { =09 } TEXTAREA { =09 } UL { =09 } .sideCol UL LI { =09 } UL.noBullet { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } UL.noBullet LI { LIST-STYLE-TYPE: none } UL.dotBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.dot.gif) } UL.bullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif) } UL.orangeBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.orange.gif)= } UL.blueBullet LI { LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.blue.gif) } OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0.25em 0px 0.25em 1.25em; PADDING-TOP: 0px } DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DT { FONT-WEIGHT: bold } DD { MARGIN-BOTTOM: 1em } HR { DISPLAY: none } .BGpowderblue { BACKGROUND-COLOR: #ebf5ff } .BGlgtblue { BACKGROUND-COLOR: #66a3c2 } .BGmedblue { BACKGROUND-COLOR: #9cf } .BGmedblue2 { BACKGROUND-COLOR: #13709d } .BGdrkblue { BACKGROUND-COLOR: #069 } .BGgrey { BACKGROUND-COLOR: #ccc } .BGllgrey { BACKGROUND-COLOR: #e5e5e5 } .BGyellow { BACKGROUND-COLOR: #ffc } .BGslateblue { BACKGROUND-COLOR: #7fb2cc } .BGwhite { BACKGROUND-COLOR: #fff } .homepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment LI { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment DD { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .HomepageFragment TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } .homepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .homepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .homepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .homepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .homepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .HomepageFragment H1 { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: #f90 } .HomepageFragment H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #f90 } .HomepageFragment H3 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H4 { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #f90 } .HomepageFragment H5 { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #f90 } .HomepageFragment H6 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #f90 } .homepageFragment A:link { COLOR: #369 } .homepageFragment A:active { COLOR: #369 } .homepageFragment A:visited { COLOR: #369 } .HomepageFragment A:link { COLOR: #369 } .HomepageFragment A:active { COLOR: #369 } .HomepageFragment A:visited { COLOR: #369 } .homepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } .HomepageFragment ADDRESS { FONT-SIZE: 11px; FONT-STYLE: normal; FONT-FAMILY: arial, helvetica, = sans-serif } TABLE.menuIEFOUR { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= PADDING-BOTTOM: 0.3em; MARGIN: 0px; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURSIDE { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif) } .menuIEFOURDOWN { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif) } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURSIDE { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } .menuIEFOURDOWN { BACKGROUND-POSITION: left center; BACKGROUND-REPEAT: no-repeat } TABLE.menuIEFOUR TD { FONT-WEIGHT: bold; FONT-SIZE: 70%; PADDING-BOTTOM: 0.2em; PADDING-TOP: = 0.2em } .menuIEFOURUser { PADDING-LEFT: 30px; FONT-WEIGHT: normal; COLOR: white; TEXT-DECORATION: = none } .menuIEFOUR A { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:link { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:visited { COLOR: #99ccff; TEXT-DECORATION: none } .menuIEFOUR A:hover { COLOR: #99ccff; TEXT-DECORATION: none } #menu A:link { =09 } #menu A:hover { =09 } #menu A:visited { =09 } #menu A { =09 } #menu UL LI { LIST-STYLE-TYPE: none } .hideNSFOUR { =09 } H3.navigationHeader { FONT-WEIGHT: bold; FONT-SIZE: 0.7em; TEXT-TRANSFORM: uppercase; COLOR: = #6089b2; FONT-STYLE: normal } H3.navigationHeader EM { FONT-SIZE: 1.1em; COLOR: #ff9b06; FONT-STYLE: normal } .homepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .HomepageFragment .mostAccessed { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0px 1.5em; PADDING-TOP: 0px } .homepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .HomepageFragment .mostAccessed LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 11px; PADDING-BOTTOM: 0px; MARGIN: 0.25em; COLOR: #ff9900; PADDING-TOP: = 0px; FONT-FAMILY: geneva,arial,helvetica,sans-serif } .homepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .HomepageFragment .mostAccessed LI DIV { FONT-WEIGHT: normal; FONT-SIZE: 100%; COLOR: #000000 } .homepageFragment .mostAccessed .title { FONT-WEIGHT: bold } .HomepageFragment .mostAccessed .title { FONT-WEIGHT: bold } DIV.banner TABLE TD A { DISPLAY: block } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css #container { MARGIN-TOP: 12px } UL.menuDOM { FLOAT: right } UL.menuIEMAC { FLOAT: right } UL.menuDOM { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= BACKGROUND-REPEAT: repeat-y; BACKGROUND-COLOR: #13709d } UL.menuDOM LI { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: none; PADDING-BOTTOM: = 0.2em; PADDING-TOP: 0.3em } UL.menuDOM LI UL LI { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; BACKGROUND: white; = PADDING-BOTTOM: 0px; COLOR: white; PADDING-TOP: 0px } .menuDOM LI { FONT-SIZE: 70% } .menuIEMAC LI { FONT-SIZE: 70% } UL.menuDOM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM LI UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuIEMAC { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } UL.menuDOM A { PADDING-RIGHT: 0.1em; DISPLAY: block; PADDING-LEFT: 0.1em; FONT-WEIGHT: = bold; PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } .hideNSFOUR LI A { WHITE-SPACE: normal } UL.menuDOM A:link { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM A:visited { COLOR: #99ccff; TEXT-DECORATION: none } UL.menuDOM LI UL LI A:hover { BACKGROUND: #e5e5e5 } UL.menuDOM LI UL LI A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } UL.menuDOM LI UL LI A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } LI.nosaved EM { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 180px; COLOR: #336699; PADDING-TOP: 5px; = TEXT-DECORATION: underline; voice-family: inherit } .bmfixie5 { =09 } UL.menuDOM A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A.menuSideArrow { BACKGROUND-POSITION: left center; PADDING-LEFT: 1em; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/arrow.blue.gif); = MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuDOM LI UL { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover UL { BORDER-RIGHT: #90d7ff 1px solid; BORDER-TOP: #90d7ff 1px solid; = DISPLAY: block; Z-INDEX: 999; BACKGROUND: white; LEFT: auto; = MARGIN-LEFT: -1.25em; BORDER-LEFT: #90d7ff 1px solid; WIDTH: 200px; = BORDER-BOTTOM: #90d7ff 1px solid; TOP: auto; voice-family: inherit } UL.menuDOM LI IFRAME { LEFT: -999em; POSITION: absolute; TOP: 2.25em } UL.menuDOM LI.menuhover IFRAME { Z-INDEX: 998; LEFT: auto; MARGIN-LEFT: -1.25em; WIDTH: 202px; TOP: auto } .bmfixie5 { =09 } UL.menuDOM LI UL LI.hoverTitle { PADDING-RIGHT: 5px; MARGIN-TOP: 0px! important; DISPLAY: block; = PADDING-LEFT: 5px; FONT-WEIGHT: bold; BACKGROUND: #ff9900; = PADDING-BOTTOM: 5px; WIDTH: 190px; COLOR: white! important; PADDING-TOP: = 5px; voice-family: inherit } LI.nosaved EM { FONT-WEIGHT: normal! important; COLOR: black! important; = TEXT-DECORATION: none! important } LI.noroll A { BACKGROUND: white } LI.noroll A:hover { BACKGROUND: white } LI.hide A { DISPLAY: none! important } .bmfixie5 { =09 } .domArrowOver { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.1.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } .domArrowOut { BACKGROUND-POSITION: left center; PADDING-LEFT: 1.25em; = BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/menu.arrow.0.gif)! = important; MARGIN: 0px 1em 0px 0px; BACKGROUND-REPEAT: no-repeat } UL.menuIEMAC A { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.1em; COLOR: #90d7ff; PADDING-TOP: 0.1em } UL.menuIEMAC A:link { TEXT-DECORATION: none } UL.menuIEMAC A { TEXT-DECORATION: none } UL.menuIEMAC LI { DISPLAY: inline; PADDING-BOTTOM: 3px } UL.menuIEMAC LI UL { LEFT: -999em; POSITION: absolute } UL.menuIEMAC { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif)!= important; PADDING-BOTTOM: 0.1em; BACKGROUND-REPEAT: repeat-y; = BACKGROUND-COLOR: #13709d } #user { PADDING-RIGHT: 2em; PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: = white } #mycart { PADDING-LEFT: 5em; BACKGROUND-IMAGE: none; COLOR: white } #menu { BORDER-RIGHT: transparent 1px solid; BORDER-TOP: transparent 1px solid; = BORDER-LEFT: transparent 1px solid; BORDER-BOTTOM: transparent 1px solid } .hideNSFOUR LI A { WHITE-SPACE: normal } .hideNSFOUR LI { WHITE-SPACE: normal } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.standards.css @import url( = http://download.interscience.wiley.com/freeflow/css/wis.dhtml.css ); #browserWarning { DISPLAY: none } .structureTable { MARGIN: 0px auto } UL { PADDING-LEFT: 1em; MARGIN: 0.25em 0em } UL.blueBullet { PADDING-LEFT: 1.5em } UL.orangeBullet { PADDING-LEFT: 1.5em } UL.bullet { PADDING-LEFT: 1.5em } UL.inline LI { DISPLAY: inline; LIST-STYLE-IMAGE: = url(http://download.interscience.wiley.com/images/icon.bullet.gif); = MARGIN-RIGHT: 6px } UL.inline LI IMG { MARGIN-RIGHT: 6px } #contentFrame .mainCol #intro { BACKGROUND-POSITION: 100% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.basic.gif); = BACKGROUND-REPEAT: no-repeat } #searchBox { BACKGROUND-POSITION: 0% 100%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.search.gif); = BACKGROUND-REPEAT: no-repeat } #citationBox { BACKGROUND-POSITION: 0% 0%; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.citation-finder.gif)= ; BACKGROUND-REPEAT: no-repeat } #contentFrame .mainCol #content .listingContent TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #content .listingFooter TABLE { WIDTH: 100%; voice-family: inherit } #contentFrame .mainCol #footer TABLE { WIDTH: 100%; voice-family: inherit } .journalIssues .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .profileLevel .mainCol #content .item TABLE { WIDTH: 100%; voice-family: inherit } .databaseLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .referenceLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsLevel .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .collectionsCollection .mainCol #content TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #intro TABLE { WIDTH: 100%; voice-family: inherit } .helpTopic #heading TABLE { WIDTH: 100%; voice-family: inherit } #headerFrame .item TABLE { WIDTH: 100%; voice-family: inherit } .aboutLevel #content TABLE { WIDTH: 100%; voice-family: inherit } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.generic.css #contentFrame .mainCol #intro { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } #contentFrame #content H4 { PADDING-BOTTOM: 4px } #contentFrame .mainCol { PADDING-BOTTOM: 10px } #contentFrame .mainCol #content { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame .mainCol #content H4 SPAN { COLOR: #000 } #contentFrame .mainCol #intro .subnav { MARGIN: 10px 0px } #contentFrame .mainCol #intro .subnav A { COLOR: #448faa; TEXT-DECORATION: none } #contentFrame .mainCol #intro .subnav DIV.active { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.inactive { PADDING-RIGHT: 3px; PADDING-LEFT: 22px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -16px; = PADDING-TOP: 2px } #contentFrame .mainCol #intro .subnav DIV.active { BACKGROUND-COLOR: #fc6 } #contentFrame .mainCol #intro .subnav DIV.inactive { =09 } #contentFrame .dataTable TD { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .dataTable TH { TEXT-ALIGN: left } .listingHeader { MARGIN: 6px 0px } .listingFooter { MARGIN: 6px 0px } #contentFrame .mainCol #content TD P.listingNav { FONT-WEIGHT: bold; MARGIN: 0px; TEXT-ALIGN: right } #contentFrame .mainCol #content P.listingNav SPAN { COLOR: #f90 } #contentFrame .mainCol #content P.listingNav STRONG { COLOR: #666 } #contentFrame .mainCol #content P.listingNav STRONG.pageSet { COLOR: #000 } #contentFrame .mainCol #content TD P.listingNav A { FONT-WEIGHT: normal } #contentFrame .mainCol #content .listingContent .dataTable TH { COLOR: #f90; BORDER-BOTTOM: #ccc 2px solid } #contentFrame .mainCol #content .listingContent .dataTable TD { BORDER-BOTTOM: #ccc 1px solid } #contentFrame .mainCol #content .formTable TH { FONT-WEIGHT: normal; TEXT-ALIGN: left } #contentFrame .mainCol #footer { BORDER-TOP: #ccc 2px solid; MARGIN: 10px 10px 0px; PADDING-TOP: 10px } #contentFrame .mainCol #footer H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .mainCol #footer TD .item { MARGIN-RIGHT: 1em } #contentFrame .mainCol #footer UL { MARGIN: 0px } #contentFrame .sideCol { MARGIN-LEFT: 1px } #contentFrame .sideCol H3 { MARGIN-BOTTOM: 6px } #contentFrame .sideCol .area { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 7px; MARGIN: = 0px 0px 15px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 7px } #contentFrame .sideCol .area LI { PADDING-BOTTOM: 4px } #contentFrame .sideCol .area P { MARGIN-BOTTOM: 0.5em } #contentFrame .sideCol .area .item { MARGIN-BOTTOM: 10px } #contentFrame .sideCol .area .line { MARGIN-BOTTOM: 10px } #contentFrame .sideCol #searchBox { WIDTH: 190px } #contentFrame .sideCol #citationBox { WIDTH: 190px } #contentFrame .sideCol #searchBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; MARGIN-BOTTOM: 0px; = PADDING-BOTTOM: 10px; BORDER-LEFT: medium none; PADDING-TOP: 10px } #contentFrame .sideCol #searchBox #articleGo { PADDING-TOP: 4px } #contentFrame .sideCol #citationBox { MARGIN-TOP: 1px; BORDER-BOTTOM: #cce5ff 1px solid } #contentFrame .sideCol #citationBox .item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 10px; MARGIN: = 0px 10px; PADDING-TOP: 10px } #contentFrame .sideCol #providedBy { =09 } #contentFrame .sideCol #latestNews { =09 } #contentFrame .sideCol #latestNews P A { FONT-WEIGHT: bold } #contentFrame .sideCol #relatedProducts { =09 } #contentFrame .sideCol #relatedProducts H6 { FONT-SIZE: 70%; MARGIN-BOTTOM: 0px; COLOR: #666 } #contentFrame .sideCol #relatedProducts UL { MARGIN-TOP: 0px; PADDING-BOTTOM: 8px } #contentFrame .sideCol #relatedProducts LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #newsFromWI LI A { FONT-WEIGHT: bold } #contentFrame .sideCol #news { =09 } #contentFrame .sideCol #featuredCollection { =09 } #contentFrame .sideCol #freeTrials { =09 } #contentFrame .sideCol #freeTrials TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct TABLE { WIDTH: 169px } #contentFrame .sideCol #featuredProduct P { FONT-WEIGHT: bold } #contentFrame .sideCol #introducing A { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion H6 { MARGIN-BOTTOM: 4px } #contentFrame .sideCol #quickQuestion LEGEND { FONT-WEIGHT: bold } #contentFrame .sideCol #quickQuestion DIV { PADDING-TOP: 6px } #contentFrame .sideCol #alsoOfInterest LI { PADDING-BOTTOM: 2px } #contentFrame .sideCol #specialIssue { =09 } #contentFrame .sideCol #specialIssue TABLE { WIDTH: 169px } #contentFrame .sideCol #newAddition { =09 } #contentFrame .sideCol #moreFromCollection { =09 } #contentFrame .sideCol #featuredProtocol { =09 } #contentFrame .sideCol #mobileEdition { =09 } #contentFrame .sideCol #profiledAlerts { =09 } #contentFrame .sideCol #recentlyPublished { =09 } #contentFrame .sideCol #recentlyPublished H6 { FONT-SIZE: 70% } #contentFrame .sideCol #searchTips { =09 } #contentFrame .sideCol #searchTips LI EM { COLOR: #999 } #contentFrame .sideCol #nowAvailableOnline { =09 } #contentFrame .sideCol #nowAvailableOnline .dataTable TH { PADDING-RIGHT: 0.5em; TEXT-ALIGN: right } #contentFrame .sideCol #forYourUsers { =09 } #contentFrame .sideCol #forYourUsers LI { PADDING-BOTTOM: 1px } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.objects.css .structureTable { =09 } #personalnavFrame { =09 } #statusFrame { =09 } #headerFrame { =09 } #contentFrame { =09 } #footerFrame { =09 } #statusFrame { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 2px } #statusFrame .txt { COLOR: #999 } #statusFrame A { FONT-WEIGHT: bold } #personalnavFrame { MARGIN-TOP: 11px } #personalnavFrame .txt { COLOR: #fff } #personalnavFrame A { FONT-WEIGHT: bold; COLOR: #9cf; TEXT-DECORATION: none } #personalnavFill { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/fill.personal-nav.gif);= WIDTH: 100%; BACKGROUND-REPEAT: repeat-y } #personalnavFill DIV { WIDTH: 70px } #personalnavMenus DIV.txt { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; WHITE-SPACE: nowrap } #personalnavSpecial { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0.15em; PADDING-TOP: 0px } #personalnavSpecialName { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 0.5em; COLOR: #069; PADDING-TOP: 0px } #headerFrame { =09 } #headerFrame IMG { DISPLAY: block } #pdfHeaderFrame { BORDER-RIGHT: #069 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: #069 2px = solid; PADDING-LEFT: 2px; FONT-SIZE: 11pt; PADDING-BOTTOM: 2px; = BORDER-LEFT: #069 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #069 2px = solid; FONT-FAMILY: arial } #footerFrame { MARGIN-TOP: 4px } #footerFrame P { LINE-HEIGHT: 140%; TEXT-ALIGN: center } #footerFrame P A { FONT-WEIGHT: bold } #footerFrame .copyright { FONT-WEIGHT: normal } #searchHeader .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #searchHeader .item H4 { MARGIN-BOTTOM: 3px } #searchHeader .item H4 SPAN { COLOR: #000 } #logoCellHome { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.home.jpg); = BACKGROUND-REPEAT: no-repeat; BACKGROUND-COLOR: #001941 } #logoCell { BACKGROUND-IMAGE: = url(http://download.interscience.wiley.com/images/bg.logo.jpg); = BACKGROUND-REPEAT: no-repeat } #sectionHeader { =09 } #breadcrumb { PADDING-LEFT: 1em; FONT-WEIGHT: bold; COLOR: #666 } #headerFrame #breadcrumb { =09 } #contentFrame .mainCol #breadcrumb { =09 } #browseSubjArea { =09 } #browseCategory { =09 } #browseProdType { =09 } #searchTitles #titlesPubtitle { MARGIN: 2px 0px; WIDTH: 140px } #searchTitles #titlesGo { MARGIN: 0px 4px } #searchArticles { WIDTH: 170px } #searchContent { WIDTH: 170px } #searchInTitle { WIDTH: 170px } #searchArticles #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchInTitle #titleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchArticles SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchInTitle SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchContent #contentKeywords { MARGIN: 2px 0px; WIDTH: 125px } #searchContent #contentGo { MARGIN: 0px 4px } #searchInTitle .txt { MARGIN: 4px 0px } #searchCitationForm #articleKeywords { MARGIN: 2px 0px; WIDTH: 164px } #searchCitationForm SELECT { MARGIN: 2px 0px; WIDTH: 170px } #searchCitationForm { BACKGROUND-COLOR: #ffffe5 } .featureBox { =09 } .mainCol { =09 } .sideCol { =09 } .lCol { =09 } .rCol { =09 } #content { =09 } .subContent { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .area { =09 } .item { =09 } .promo { =09 } .intro { =09 } .subnav { =09 } .info { =09 } .tools { =09 } .hdr { =09 } .prerendered { =09 } .listingHeader { =09 } .listingContent { =09 } .listingFooter { =09 } .featureBox { MARGIN: 10px 0px 0px 20px } .featureBox .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } .featureBox UL { PADDING-BOTTOM: 10px } .formTable { =09 } .dataTable { =09 } .debug { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; BORDER-LEFT: = red 1px solid; BORDER-BOTTOM: red 1px solid; BACKGROUND-COLOR: #fcc } #browserWarning { BORDER-RIGHT: #c00 1px solid; PADDING-RIGHT: 0.3em; BORDER-TOP: #c00 = 1px solid; PADDING-LEFT: 0.3em; FONT-SIZE: 100%; PADDING-BOTTOM: 0.3em; = MARGIN: 5px 28px; BORDER-LEFT: #c00 1px solid; COLOR: #300; PADDING-TOP: = 0.3em; BORDER-BOTTOM: #c00 1px solid; FONT-FAMILY: arial; = BACKGROUND-COLOR: #fef } .invisible { OVERFLOW: hidden; WIDTH: 0px; POSITION: absolute; HEIGHT: 0px } .pageSet { COLOR: #000 } .pageSetLabel { COLOR: #666 } .issueNav { WHITE-SPACE: nowrap } .available { COLOR: #390 } .unavailable { COLOR: #f00 } .productImage { MARGIN-RIGHT: 10px } .linkMore { FONT-WEIGHT: bold } .linkBack { FLOAT: left; MARGIN: 10px } .linkPrint { FLOAT: right; MARGIN: 10px 20px 0px 0px } .linkTop { CLEAR: both; TEXT-ALIGN: right } .icon { VERTICAL-ALIGN: middle; MARGIN-RIGHT: 2px } .spacer { =09 } .border { =09 } .line { MARGIN: 10px 0px } .lineNopad { =09 } .spacer IMG { =09 } .spacer IMG { DISPLAY: block } .border IMG { DISPLAY: block } .line IMG { DISPLAY: block } .lineNopad IMG { DISPLAY: block } #errorTxt { FONT-WEIGHT: bold; COLOR: #c00 } #errorList LI { FONT-WEIGHT: bold; COLOR: #c00! important; LIST-STYLE-TYPE: none } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/wis.template.journal.css #contentFrame #intro { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } #contentFrame #intro .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } #contentFrame #intro .published { PADDING-RIGHT: 0px; PADDING-LEFT: 8px; PADDING-BOTTOM: 6px; MARGIN: = 10px 0px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 0px } #contentFrame #intro .published P { MARGIN: 0px; COLOR: #999 } #contentFrame #intro .info { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #intro .info H2 { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #intro .info H6 { MARGIN: 3px 0px } #contentFrame #intro .info H6 A { COLOR: #333 } #contentFrame #intro .info P { PADDING-LEFT: 2em; MARGIN: 0px; COLOR: #666; TEXT-INDENT: -2em } #contentFrame #intro .tools { PADDING-LEFT: 6px } #contentFrame #intro .lCol { PADDING-RIGHT: 10px } #contentFrame #intro .rCol LI A { FONT-WEIGHT: bold } #contentFrame #intro #subnav { BORDER-TOP: #ccc 1px solid; MARGIN-TOP: 8px; COLOR: #000; LINE-HEIGHT: = 150%; PADDING-TOP: 4px } #contentFrame #intro #subnav SPAN A { FONT-WEIGHT: bold } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } #contentFrame .mainCol #content { PADDING-TOP: 16px } .journalAbstract .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalReferences .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 16px! important } .journalArticleMain .mainCol #content .subContent { =09 } #contentFrame #content UL { PADDING-BOTTOM: 10px } #contentFrame #content OL { PADDING-BOTTOM: 10px } #contentFrame #content .issueNav { MARGIN: 0px; TEXT-ALIGN: center } #contentFrame #content .issueNav SPAN { FONT-WEIGHT: bold; COLOR: #f90 } #contentFrame #intro #pdfInfoArea { FONT-SIZE: 70%; COLOR: #333; FONT-FAMILY: geneva, arial, helvetica, = sans-serif } .journalLevel #intro #branding { BACKGROUND-COLOR: #fff } .journalIssues { =09 } .journalIssues #content .item { MARGIN-BOTTOM: 1em } .journalIssues #content .item P { MARGIN-BOTTOM: 1em } .journalIssues #content .inlineNav { PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0.5em; MARGIN: 4em 0px 0.5em; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #ccc 1px solid } .journalIssues #content .featureBox .item { MARGIN-BOTTOM: 0px } .journalToc #intro H2 { MARGIN-BOTTOM: 2px } .journalToc #content .line { MARGIN: 4px 0px } .journalLevel #content OL { PADDING-LEFT: 10px } .journalLevel #content .refListing LI { PADDING-LEFT: 6px; PADDING-BOTTOM: 10px } .journalAbstract #content .item P { MARGIN-BOTTOM: 0.5em } .journalAdvertising { =09 } .journalAdvertising #content .line { MARGIN-TOP: 2em } .journalSubscribe { =09 } .journalSubscribe #content .line { MARGIN-TOP: 1em } .journalAuthors { =09 } .journalAuthors OL { PADDING-LEFT: 0.5em } .journalAuthors OL LI { PADDING-BOTTOM: 1em } .journalEditorial { =09 } .journalProductinfo { =09 } .journalArticleMain { =09 } .journalArticleMain .mainCol #intro { BACKGROUND-IMAGE: none! important } .journalArticleMain #intro .item { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #intro .item .info { PADDING-LEFT: 0px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro .item .tools { PADDING-TOP: 10px! important } .journalArticleMain #searchBox { BORDER-RIGHT: #99c2d6 1px solid; WIDTH: 150px } .journalArticleMain #intro #searchBox .item { PADDING-RIGHT: 10px! important; PADDING-LEFT: 10px! important; = PADDING-BOTTOM: 10px! important; PADDING-TOP: 10px! important } .journalArticleMain #intro #searchBox #articleKeywords { WIDTH: 120px } .journalArticleMain #content { PADDING-LEFT: 0px! important; PADDING-TOP: 0px! important } .journalArticleMain #content .item P { MARGIN-BOTTOM: 0.5em } #headerFrame .BGdrkblue .item { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; BACKGROUND: #565565; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } #headerFrame .item IMG { DISPLAY: inline } DIV.framedHeaderHack { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = PADDING-TOP: 10px } H2.framedHeaderHack { FONT-SIZE: 80%; COLOR: #369 } #contentFrame #content .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content .prerendered TABLE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #contentFrame #content .prerendered TD { FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TH { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333; BACKGROUND-COLOR: #fff } #contentFrame #content .prerendered TD A { COLOR: #333 } #contentFrame #content .prerendered TD FONT { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT A { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered FONT[size=3D'+1'] { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #666 } #contentFrame #content .prerendered FONT[size=3D'+2'] { FONT-WEIGHT: bold; FONT-SIZE: 14px } #contentFrame #content .prerendered FONT[size=3D'4'] A { FONT-SIZE: 14px; COLOR: #090 } #contentFrame #content .prerendered P { FONT-SIZE: 12px; COLOR: #333 } #contentFrame #content .prerendered HR { DISPLAY: block } .journalArticleNav { MARGIN-TOP: 10px } .journalArticleNav .prerendered { FONT-SIZE: 12px; COLOR: #333; FONT-FAMILY: arial, helvetica, sans-serif } .journalArticleNav .prerendered UL { MARGIN: 1em 0px 1em 0.5em } .journalArticleNav .prerendered UL LI { MARGIN: 0.5em 0px } .prerendered A:link { COLOR: #369 } .prerendered A:visited { COLOR: #369 } .prerendered A:active { COLOR: #369 } .prerendered A:hover { =09 } .prerendered .articleTitle { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .articleSubTitle { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .mainSectionHeader { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 110%; TEXT-TRANSFORM: = uppercase; COLOR: #f90 } .prerendered .firstLevelHeading { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .secondLevelHeading { DISPLAY: block; FONT-SIZE: 11pt; COLOR: #369 } .prerendered .thirdLevelHeading { DISPLAY: block; COLOR: #369 } .prerendered .otherHeadings { FONT-SIZE: 10pt; COLOR: #369 } .prerendered .referenceNum { FONT-SIZE: 10pt; COLOR: #369 } .journalReferences #content .subContent .item P { MARGIN-BOTTOM: 0.5em } #contentFrame #content #accessdeniedLogin TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedPurchaseBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } #contentFrame #content #accessdeniedRegisterBox TD P { FONT-SIZE: 11px; FONT-FAMILY: arial, helvetica, sans-serif } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/css/bpg.css .prerendered .invisible-anchor { DISPLAY: none } .prerendered A { COLOR: #336699; TEXT-DECORATION: none } .prerendered .body-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .appendix-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .toc-content { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .article { FONT-FAMILY: arial,helvetica,sans-serif } .prerendered .doi-title { MARGIN-BOTTOM: 6pt } .prerendered .articletext { MARGIN-TOP: 12pt; FONT-WEIGHT: bold; FONT-SIZE: 12px; MARGIN-BOTTOM: = 0.4em; TEXT-TRANSFORM: uppercase; COLOR: #333333 } .prerendered P.para { MARGIN-TOP: 0em } .prerendered .titlegroup { MARGIN-BOTTOM: 12pt } .prerendered .title-document { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 140% } .prerendered .title-surtitle { FONT-WEIGHT: bold; FONT-SIZE: 100%; COLOR: #666666 } .prerendered .title-subtitle { FONT-WEIGHT: bold; FONT-SIZE: 100%; COLOR: #666666 } .prerendered .correspondence-label { =09 } .prerendered P.reference-list-para { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: middle; LINE-HEIGHT: 150%; PADDING-TOP: 0px } .prerendered .clear-both { CLEAR: both; LINE-HEIGHT: 0px; HEIGHT: 0px } .prerendered UL.references-list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.references-list { CLEAR: both } .prerendered UL.references-list LI { CLEAR: both } .prerendered UL.references-list SPAN.reference-list-label { FLOAT: left; WIDTH: 3% } .prerendered UL.references-list P.reference-list-para { FLOAT: left; MARGIN: 0px; WIDTH: 97% } .prerendered UL.toc-list LI { FONT-SIZE: 100% } .prerendered UL.references-list LI { FONT-SIZE: 100% } .prerendered UL.listlevel1 LI { FONT-SIZE: 100%; LINE-HEIGHT: 120% } .prerendered UL.listlevel2 LI { FONT-SIZE: 100% } .prerendered UL.listlevel3 LI { FONT-SIZE: 100% } .prerendered UL.listlevel4 LI { FONT-SIZE: 100% } .prerendered UL.listlevel5 LI { FONT-SIZE: 100% } .prerendered UL.listlevel6 LI { FONT-SIZE: 100% } .prerendered UL LI { FONT-SIZE: 100% } .prerendered P.list-para { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px } .prerendered UL.listlevel1 { MARGIN-BOTTOM: 12pt } .prerendered UL.listlevel1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .prerendered UL.listlevel1 { CLEAR: both } .prerendered UL.listlevel2 { CLEAR: both } .prerendered UL.listlevel3 { CLEAR: both } .prerendered UL.listlevel4 { CLEAR: both } .prerendered UL.listlevel5 { CLEAR: both } .prerendered UL.listlevel6 { CLEAR: both } .prerendered UL.listlevel1 LI { CLEAR: both } .prerendered UL.listlevel2 LI { CLEAR: both } .prerendered UL.listlevel3 LI { CLEAR: both } .prerendered UL.listlevel4 LI { CLEAR: both } .prerendered UL.listlevel5 LI { CLEAR: both } .prerendered UL.listlevel6 LI { CLEAR: both } .prerendered UL.listlevel1 SPAN.list-label { FLOAT: left; WIDTH: 5%; LINE-HEIGHT: 150% } .prerendered UL.listlevel1 P.list-para { FLOAT: left; MARGIN: 0px; WIDTH: 95%; LINE-HEIGHT: 150% } .prerendered UL.listlevel2 { CLEAR: both; MARGIN: 0px 0px 10px 5% } .prerendered UL.listlevel2 { CLEAR: both; MARGIN: 0px 0px 10px 5% } .prerendered UL.listlevel3 { MARGIN: 0px 0px 20px 5% } .prerendered UL.listlevel3 SPAN.list-label { FLOAT: left; WIDTH: 5% } .prerendered UL.listlevel3 P.list-para { FLOAT: left; WIDTH: 95% } .prerendered UL.listlevel4 { CLEAR: both; MARGIN: 0px 0px 30px 5% } .prerendered UL.listlevel5 { MARGIN: 0px 0px 40px 5% } .prerendered UL.listlevel6 { MARGIN: 0px 0px 50px 5% } .prerendered UL.listlevel2 SPAN.list-label { FLOAT: left; WIDTH: 5% } .prerendered UL.listlevel2 P.list-para { FLOAT: left; WIDTH: 95% } .prerendered .table { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt; TEXT-ALIGN: center } .prerendered .table-title { FONT-WEIGHT: bold } .prerendered H1 { MARGIN-TOP: 12pt; FONT-WEIGHT: bold; FONT-SIZE: 1.1em; MARGIN-BOTTOM: = 0.4em; COLOR: #336699 } .prerendered H1 .abstract-title { MARGIN-TOP: 0pt; FONT-WEIGHT: bold; FONT-SIZE: 1.1em; MARGIN-BOTTOM: = 0.4em } .prerendered H1 .abstract-title-with-preceding-heading { MARGIN-TOP: 0pt; FONT-WEIGHT: bold; FONT-SIZE: 1.1em; MARGIN-BOTTOM: = 0.4em } .prerendered H2 { MARGIN-TOP: 0.4em; FONT-WEIGHT: bold; FONT-SIZE: 1em; MARGIN-BOTTOM: = 0em; COLOR: #336699 } .prerendered H3 { MARGIN-TOP: 0pt; FONT-WEIGHT: bold; FONT-SIZE: 1em; MARGIN-BOTTOM: = 0.4em; COLOR: #336699; FONT-STYLE: italic } .prerendered .h3-inline { FONT-WEIGHT: bold; FONT-SIZE: 1em; COLOR: #336699; FONT-STYLE: italic } .prerendered H4 { MARGIN-TOP: 0pt; FONT-SIZE: 1em; MARGIN-BOTTOM: 0.4em; COLOR: #336699; = FONT-STYLE: italic } .prerendered .h4-inline { FONT-SIZE: 1em; COLOR: #336699; FONT-STYLE: italic } .prerendered H5 { MARGIN-TOP: 0pt; FONT-SIZE: 1em; MARGIN-BOTTOM: 0.4em } .prerendered .h5-inline { DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 1em; FONT-STYLE: normal } .prerendered .heading5-inline { DISPLAY: block; FONT-WEIGHT: bold; FONT-SIZE: 100%; COLOR: #666666 } .prerendered .correspondence-address { MARGIN-TOP: 8pt; DISPLAY: block } .prerendered .bpg40copyright { MARGIN-TOP: 16pt; DISPLAY: none } .prerendered .doi-block { MARGIN-TOP: 16pt; DISPLAY: block; MARGIN-BOTTOM: 8pt } .prerendered .doi-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .keywords-block { MARGIN-TOP: 16pt; DISPLAY: block } .prerendered .keyword-title { DISPLAY: block; FONT-WEIGHT: bold } .prerendered .abstract-content { CLEAR: left; DISPLAY: block; PADDING-TOP: 1pt } .prerendered .b { FONT-WEIGHT: bold } .prerendered .highlight { FONT-WEIGHT: bold } .prerendered .i { FONT-STYLE: italic } .prerendered .overline { TEXT-DECORATION: overline } .prerendered .slanted { FONT-STYLE: oblique } .prerendered .smallcapitals { FONT-VARIANT: small-caps } .prerendered .strike { TEXT-DECORATION: line-through } .prerendered .tt { FONT-FAMILY: "Courier","Lucida Sans Typewriter","Courier = New","LucidaTypewriter", fixed } .prerendered .u { TEXT-DECORATION: underline } .prerendered .uu { TEXT-DECORATION: underline } .prerendered .openface { =09 } .prerendered .roman { FONT-STYLE: normal } .prerendered .sansserif { FONT-FAMILY: sans-serif } .prerendered .scriptface { =09 } .prerendered .questiongroup { =09 } .prerendered .question { =09 } .prerendered .answer { =09 } .prerendered .hint { =09 } .prerendered .feedback { =09 } .prerendered .toc-content { =09 } .prerendered .toc-journal-title { FONT-WEIGHT: bold } .prerendered .toc-issn { =09 } .prerendered .toc-vol-issue { MARGIN-TOP: 12pt } .prerendered .toc-pages { =09 } .prerendered .toc-sections { MARGIN-TOP: 12pt; MARGIN-BOTTOM: 12pt } .prerendered .toc-tables { =09 } .prerendered .toc-figures { =09 } .prerendered .toc-abstract-only { =09 } .prerendered .block_formula { DISPLAY: block; MARGIN: 1em 0pt; WIDTH: 98%; WHITE-SPACE: nowrap; = POSITION: relative } .prerendered .block_formula .formula_caption { RIGHT: 0px; POSITION: absolute; TOP: 33% } .prerendered .block_formula .formula_display { =09 } .prerendered .inline_formula IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .reference-document-title { =09 } .prerendered .reference-subtitle-title { =09 } .prerendered .reference-journal-title { FONT-STYLE: italic } .prerendered .reference-book-title { FONT-STYLE: italic } .prerendered .reference-conference-title { =09 } .prerendered .reference-other-title { =09 } .prerendered .reference-date { =09 } .prerendered .reference-volume { FONT-WEIGHT: bold } .prerendered .reference-page { =09 } .prerendered .reference-publisher { =09 } .prerendered .reference-edition { =09 } .prerendered .reference-issue { =09 } .prerendered .reference-thesis { =09 } .prerendered .reference-inpress { =09 } .prerendered .reference-supplement { =09 } .prerendered .reference-miscellaneoustext { =09 } .prerendered .figure-legend { FONT-WEIGHT: bold; FONT-SIZE: 0.8em } .prerendered P.legend-para { MARGIN-TOP: 0em; MARGIN-BOTTOM: 0em; MARGIN-LEFT: 1.6em } .prerendered .figure { MARGIN-BOTTOM: 6pt } .prerendered .image-links { FONT-SIZE: 0.8em; MARGIN-LEFT: 2em } .prerendered .table-legend { =09 } .prerendered .toc-content { =09 } .prerendered TABLE.data-table TH { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .prerendered TABLE.data-table TD { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .prerendered .bp_abstractinfo { DISPLAY: none } .prerendered .header-footnotes { MARGIN-TOP: 6pt } .prerendered .inline_image IMG { MARGIN-BOTTOM: 0.3em; VERTICAL-ALIGN: middle } .prerendered .fixed-image { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered .fixed-legend { MARGIN-TOP: 0.5em; MARGIN-BOTTOM: 1em } .prerendered A.externallink { COLOR: #336699 } .prerendered .subsection-box { BACKGROUND-COLOR: #f9e3df } .prerendered .tbltl { MARGIN-TOP: 0.5em } .prerendered .bookdetails { MARGIN-TOP: 8pt; MARGIN-BOTTOM: 8pt } .prerendered .references .reference-content { DISPLAY: inline } .prerendered .para .reference-content { DISPLAY: inline } .prerendered .reference-content { DISPLAY: block } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/js/site.js /************************************************************************= ***************************=0A= FILE: site.js=0A= AUTHOR: Jonathan Sugar, Chris Neatby-Smith and Digital Pulp. July = 2003.=0A= =0A= DESCRIPTION: Javascript relating to site wide functionality across =0A= InterScience.=0A= =0A= INCLUDES FUNCTIONS=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Search Functions=0A= ----------------=0A= =0A= selectAndSubmit() - for deciding where to submit a query based on the = state of the form.=0A= processallContentSearch() - for validating form input for an all = content search.=0A= processTitleSearch() - for validating form input for a Title search.=0A= checkCitationSearch() - for validating the citation search form.=0A= selectAll() - check all the checkboxes in a form.=0A= do_popup() - stasa Acronym Finder window popup function.=0A= =0A= =0A= Other Functions=0A= ---------------=0A= =0A= fixInlineLists() - fix netscape 4.x bug where

tags with images = display both an image and=0A= the default bullet. =0A= =0A= = *************************************************************************= **************************/=0A= =0A= var http =3D false;=0A= if(navigator.appName =3D=3D "Microsoft Internet Explorer") {=0A= http =3D new ActiveXObject("Microsoft.XMLHTTP");=0A= } else {=0A= http =3D new XMLHttpRequest();=0A= } =0A= =0A= // Global Variables=0A= var debug =3D false;=0A= var first =3D true;=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= /*=0A= * Used to switch search mode between APS and TitleFinder on quicksearch = boxes=0A= * = -------------------------------------------------------------------------= --=0A= *=0A= * 1. Decides which search is required based on the value of the radio = buttons=0A= * in 'document.formSelector.whichForm'.=0A= *=0A= * 2. Calls individual functions to process the forms and submit them.=0A= *=0A= */=0A= function selectAndSubmit()=0A= {=0A= var formSelection;=0A= =0A= // find out which form we need to process.=0A= var selector =3D document.formSelector.whichForm;=0A= for (var i =3D 0; i < selector.length; i++){=0A= if (selector[i].checked){=0A= formSelection =3D selector[i].value;=0A= }=0A= }=0A= =0A= // Call the relevent function to process the required form.=0A= if(formSelection =3D=3D "allContentSearch"){=0A= processallContentSearch(document.allContentSearchForm, = document.formSelector)=0A= }=0A= else if(formSelection =3D=3D "searchTitles"){=0A= processTitleSearch(document.searchTitles, document.formSelector)=0A= }=0A= else{=0A= return false;=0A= }=0A= =0A= //@@@DM It was anoying me this error =0A= return false;=0A= }=0A= =0A= /*=0A= *Process the ADS search form=0A= *=0A= */=0A= function trim(str)=0A= {=0A= return str.replace(/(^\s*)|(\s*$)/g,"");=0A= }=0A= =0A= function ADSquery(t) {=0A= var keyword =3D trim(t.getElementsByTagName("input")[0].value);=0A= if (keyword!=3D"") {=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= t.target=3D"popup";=0A= t.qsearch.value=3Dkeyword;=0A= return true;=0A= = //processADSSearch(document.ADSSearchForm,document.ADSQueryForm,keyword);=0A= } else {=0A= alert("Please input a keyword for ADS searching before clicking go");=0A= return false;=0A= }=0A= }=0A= /*=0A= function processADSSearch(hiddenForm ,queryForm , str) {=0A= var terms =3D str;=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= formToSubmit.qsearch.value =3D terms;=0A= = window.open("","popup","toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar= =3Dno,scrollbars=3Dyes,resizable=3Dyes,width=3D800,height=3D500");=0A= formToSubmit.action =3D = "http://adsabs.harvard.edu/cgi-bin/nph-basic_connect"=0A= formToSubmit.target =3D "popup";=0A= formToSubmit.submit();=0A= }=0A= */=0A= =0A= /*=0A= * Process the allContentSearch form=0A= * ---------------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= function processallContentSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.WISsearch1.value =3D formToProcess.terms.value;=0A= formToSubmit.submit(); =0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= /*=0A= * Process the Title Search form=0A= * -----------------------------=0A= * 1. Perform form validation, checking for empty fields.=0A= * Give the user a relevent message if required.=0A= *=0A= * 2. Process/Assign the appropriate form elements and submit the form.=0A= */=0A= =0A= function processTitleSearch(hiddenForm, queryForm)=0A= {=0A= var formToSubmit =3D hiddenForm;=0A= var formToProcess =3D queryForm;=0A= =0A= // Do some basic form validation=0A= if(formToProcess.terms.value !=3D "")=0A= {=0A= formToSubmit.query.value =3D formToProcess.terms.value;=0A= formToSubmit.submit();=0A= }=0A= else=0A= {=0A= alert("You must enter a search term in the text box before you click = go.");=0A= }=0A= }=0A= =0A= function doCitationSearch()=0A= {=0A= var form =3D document.citsearchform;=0A= if(checkCitationSearch())=0A= {=0A= form.action =3D "/search/allsearch";=0A= form.submit();=0A= }=0A= }=0A= =0A= // Preprocesses the arguments sent to CitationSearch and checks validity = of user inputs.=0A= function checkCitationSearch()=0A= {=0A= var supplementFound =3D 0; //increment if found;=0A= var hyphenFound =3D 0; //increment if found;=0A= var fm =3D document.citsearchform;=0A= var errmsg =3D "Please use the valid digits '0' to '9'";=0A= // remove all spaces=0A= fm.volume.value =3D fm.volume.value.replace(/ /g, "");=0A= fm.issue.value =3D fm.issue.value.replace(/ /g, "");=0A= fm.pages.value =3D fm.pages.value.replace(/ /g, "");=0A= =0A= if (fm.issn.value.length > 0 && fm.volume.value.length > 0 && = fm.pages.value.length > 0)=0A= {=0A= // check page range=0A= var pageRange =3D fm.pages.value;=0A= var volume =3D fm.volume.value;=0A= var issue =3D fm.issue.value;=0A= var continueFlag =3D 0;=0A= //check the volume=0A= // if (isNaN(volume))=0A= // {=0A= // // volume failed checking=0A= // alert("Volume is invalid. "+errmsg+".");=0A= // return false;=0A= // }=0A= //check the issue=0A= if ((issue.length !=3D 0) && isNaN(issue))=0A= {=0A= // issue failed checking=0A= alert("Issue is invalid. "+errmsg+" or leave blank.");=0A= return false;=0A= }=0A= //check the page range=0A= if (isNaN(pageRange))=0A= {=0A= var isValid =3D false;=0A= // check for hyphen=0A= var hyphenIndex =3D pageRange.indexOf("-");=0A= if ((hyphenIndex !=3D -1) && (hyphenIndex =3D=3D = pageRange.lastIndexOf("-")))=0A= {=0A= // we have only one hyphen, so extract each number=0A= var firstNum =3D pageRange.substring(0, hyphenIndex);=0A= var secondNum =3D pageRange.substring(hyphenIndex + 1);=0A= // check for S=0A= var firstS =3D firstNum.indexOf("S");=0A= var secondS =3D secondNum.indexOf("S");=0A= if (firstS =3D=3D secondS)=0A= {=0A= if ((firstS =3D=3D -1) && isNum(firstNum) && isNum(secondNum) && = (firstNum.length > 0) && (secondNum.length > 0))=0A= isValid =3D true; // both inputs are digits=0A= else if (firstS =3D=3D 0)=0A= {=0A= var firstNumNoS =3D firstNum.substring(1);=0A= var secondNumNoS =3D secondNum.substring(1);=0A= if (isNum(firstNumNoS) && isNum(secondNumNoS) && = (firstNumNoS.length > 0) && (secondNumNoS.length > 0))=0A= isValid =3D true; // both inputs are Sdigits=0A= }=0A= =0A= }=0A= }=0A= if (isValid)=0A= {=0A= return true;=0A= }=0A= else=0A= {=0A= alert("The page range is invalid. "+errmsg+" and a hyphen '-' if = required.");=0A= return false;=0A= }=0A= }=0A= return true;=0A= }=0A= else=0A= {=0A= alert("Volume and pages are required fields. Please make sure data has = been entered for both fields.");=0A= return false;=0A= }=0A= }=0A= =0A= // returns true if a is an Integer.=0A= function isNum(a)=0A= { return !(isNaN(a)); }=0A= =0A= function fixInlineLists() {=0A= if (!document.getElementById) return;=0A= var allLIs =3D document.getElementsByTagName('li');=0A= var bulletNode =3D document.createElement('img');=0A= bulletNode.src = =3D"http://download.interscience.wiley.com/images/icon.bullet.gif";=0A= =0A= for (var i=3D0; iAbstract | References';=0A= }=0A= //alert("URL: " + loc + "\nStart Index: " + startIndex + "\nEnd Index: = " + endIndex + "\nPage: " + page + "\nLink Text: " + links);=0A= return links;=0A= }=0A= =0A= =0A= function selectAll(fm)=0A= {=0A= //var fm =3D document.viewSelectedForm;=0A= =0A= for (var i =3D 0; i < fm.elements.length; i++)=0A= {=0A= if (fm.elements[i].type =3D=3D 'checkbox' /*&& fm.elements[i].name = =3D=3D 'ID'*/)=0A= {=0A= fm.elements[i].checked =3D true;=0A= }=0A= }=0A= }=0A= =0A= =0A= function do_popup(file)=0A= {=0A= var w =3D window.open(file, 'popWin', = 'width=3D350,height=3D500,scrollbars=3Dyes');=0A= =0A= }=0A= =0A= =0A= function mailTool(itemID, useurl, skin)=0A= {=0A= //var url =3D "/cgi-bin/mailform?item=3D"+itemID;=0A= var url =3D "/cgi-bin/mailform?item=3D" + itemID + "&skin=3D" + skin;=0A= var parameters =3D = 'status=3Dno,scrollbars=3Dno,resizable=3Dyes,width=3D400,height=3D475';=0A= =0A= if (useurl !=3D "")=0A= {=0A= url +=3D "&useurl=3D"+useurl;=0A= }=0A= =0A= if ((isNaN(parseInt(itemID))=3D=3Dtrue)||(arguments.length >=3D 4 && = arguments[3] =3D=3D 'cluster'))=0A= {=0A= url +=3D '&type=3Dcluster';=0A= }=0A= =0A= //check whether the last 2 arguments is used for urllink.=0A= // urllink is needed to open up mail form for mrw pages on tomcat = port=0A= if (arguments.length>=3D5 && = arguments[arguments.length-2]=3D=3D'urllink' && = arguments[arguments.length-1]!=3D'')=0A= {=0A= url =3D arguments[arguments.length-1] + url;=0A= }=0A= =0A= if (arguments.length>=3D5 && arguments[3]=3D=3D'currentlink' && = arguments[4]!=3D'')=0A= {=0A= url =3D url + '¤tLink=3D' + arguments[4];=0A= =0A= //processing specific cases=0A= if (arguments[4]=3D=3D'jcatalogjsphdr')=0A= {=0A= //get the issn and pass it the next stage for processing=0A= var currloc =3D location.href;=0A= var issnloc =3D currloc.indexOf("&issn=3D");=0A= if (issnloc !=3D -1)=0A= {=0A= url =3D url + '¤tISSN=3D' + = currloc.substring(issnloc+6);=0A= }=0A= }=0A= // issn is needed for cocoon rendered mrw to form the final url.=0A= else if ( (arguments[4]=3D=3D'cocoonmrwhome') || = (arguments[4]=3D=3D'cocoonmrwarticle') )=0A= {=0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'issn' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tISSN=3D' + arguments[6];=0A= }=0A= //getting the parameters of the currently shown mrw from the = url=0A= //the method used here is a little crude, it extracts the = values from the current url of the page the user is in =0A= //to pass it to the background program to reconstruct the = requred url=0A= if (arguments[4]=3D=3D'cocoonmrwhome')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= var mrwFileParam =3D mrwParamArr[6];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= mrwFileParam =3D = mrwFileParam.substring(0,seploc);=0A= }=0A= seploc =3D mrwFileParam.indexOf("?");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwUrlParam=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= =0A= }=0A= else if (arguments[4]=3D=3D'cocoonmrwarticle')=0A= {=0A= var currloc =3D location.href;=0A= var mrwParamArr =3D currloc.split("/");=0A= if (mrwParamArr.length >=3D 7)=0A= {=0A= url =3D url + '&mrwPath=3D' + mrwParamArr[5];=0A= url =3D url + '&mrwAid=3D' + mrwParamArr[7];=0A= url =3D url + '&mrwVersion=3D' + mrwParamArr[8];=0A= var mrwFileParam =3D mrwParamArr[9];=0A= var seploc =3D mrwFileParam.indexOf("#");=0A= if (seploc !=3D -1)=0A= {=0A= url =3D url + '&mrwSection=3D' + = mrwFileParam.substring(seploc+1);=0A= url =3D url + '&mrwDocType=3D' + = mrwFileParam.substring(0,seploc);=0A= }=0A= else=0A= {=0A= url =3D url + '&mrwDocType=3D' + mrwFileParam;=0A= }=0A= }=0A= }=0A= }=0A= }=0A= =0A= //checking if a html file exists in the url=0A= var tmpfname =3D location.href;=0A= var loc =3D tmpfname.indexOf("?");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(0,loc);=0A= }=0A= loc =3D tmpfname.indexOf(".html");=0A= if (loc !=3D -1)=0A= {=0A= loc =3D tmpfname.lastIndexOf("/");=0A= if (loc !=3D -1)=0A= {=0A= tmpfname =3D tmpfname.substring(loc+1);=0A= url =3D url + '¤tFile=3D' + tmpfname;=0A= }=0A= }=0A= =0A= if (arguments.length>=3D7 && arguments[5]=3D=3D'currentyear' && = arguments[6]!=3D'')=0A= {=0A= url =3D url + '¤tYear=3D' + arguments[6];=0A= }=0A= =0A= eval("wileyMailTool =3D = window.open('"+url+"','MailTool','"+parameters+"')");=0A= =0A= // If object exists ensure has focus=0A= if (eval("wileyMailTool") && window.focus)=0A= eval("wileyMailTool").focus();=0A= }=0A= =0A= =0A= /*=0A= * 1. Find the links we need to alter.=0A= * 2. For each link apply the new styles we need.=0A= */=0A= function fixAbsRefRendering()=0A= { =0A= var table =3D document.getElementById('prerendered');=0A= var anchors =3D table.getElementsByTagName('a');=0A= for (var i =3D 1; i < anchors.length; i++)=0A= {=0A= if(anchors[i].href !=3D"") =0A= { =0A= applyAbsRefStyleCorrection(anchors[i]);=0A= =0A= }=0A= }=0A= }=0A= =0A= function applyAbsRefStyleCorrection(currentLink)=0A= {=0A= currentLink.style["color"] =3D "#369";=0A= currentLink.style["fontWeight"] =3D "normal";=0A= currentLink.style["marginLeft"] =3D "3px";=0A= currentLink.style["marginRight"] =3D "5px";=0A= }=0A= =0A= function populatePage(formName)=0A= {=0A= if (formName.Page.value =3D=3D '')=0A= {=0A= formName.Page.value =3D document.location;=0A= }=0A= }=0A= =0A= function equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= document.writeln(' 3D"blank"

');=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function old_equalizeColumnWidth(numFeatures)=0A= {=0A= var numberOfFeatures =3D numFeatures; =0A= // Percentage width of table to use for each column.=0A= var percentPerFeature =3D Math.floor(100 / numberOfFeatures); =0A= // Number of columns in total. Content cols + seperators. =0A= =0A= if(debug)=0A= {=0A= alert("Number of feature boxes: " + numberOfFeatures + "\nPercent per = feature: " + percentPerFeature);=0A= }=0A= =0A= document.writeln("");=0A= for(var i =3D 0; i < numberOfFeatures; i++)=0A= { =0A= if (netscape4 =3D=3D false)=0A= {=0A= document.writeln(' 3D"blank"

'); =0A= }=0A= }=0A= document.writeln("");=0A= }=0A= =0A= function writeFBoxCell()=0A= {=0A= if(first)=0A= {=0A= document.write('');=0A= }else=0A= {=0A= document.write('');=0A= }=0A= numFeatures ++;=0A= }=0A= =0A= =0A= //=0A= // escape apostrophe characters within a string=0A= //=0A= function encode(str)=0A= {=0A= out =3D '';=0A= =0A= for (a =3D 0; a < str.length; a++)=0A= {=0A= c =3D str.charAt(a);=0A= =0A= if (c =3D=3D "'")=0A= {=0A= out +=3D '\\';=0A= }=0A= =0A= out +=3D c;=0A= }=0A= =0A= return out;=0A= }=0A= =0A= =0A= //=0A= //=0A= //=0A= function escapeEntities(str)=0A= {=0A= while (str.indexOf("'") > -1)=0A= {=0A= pos =3D str.indexOf("'");=0A= str =3D str.substr(0, pos) + '\\\'' + str.substr(pos + 6);=0A= }=0A= =0A= return str;=0A= }=0A= =0A= =0A= // new popup function less intrusive just uses the DOM to pickup links = with an exwin class.=0A= // currently implemented for Figure popups on D&T homepage.=0A= =0A= function exLinks()=0A= {=0A= if (document.getElementById)=0A= {=0A= var aObject =3D document.getElementsByTagName("a");=0A= for (var x=3D0; x=3D 0) { appname =3D "ns"; }=0A= else if (navigator.appName.indexOf("Explorer") >=3D 0) { appname =3D = "ie"; }=0A= if (navigator.userAgent.indexOf("Mozilla/2") >=3D 0) {=0A= version =3D 2;=0A= } else if (navigator.userAgent.indexOf("Mozilla/3") >=3D 0) {=0A= version =3D 3;=0A= } else if (navigator.userAgent.indexOf("Mozilla/4") >=3D 0) {=0A= version =3D 4;=0A= } else if (navigator.userAgent.indexOf("Mozilla/5") >=3D 0) {=0A= version =3D 5;=0A= }=0A= =0A= // Browser detect globals:=0A= var uaStr =3D navigator.userAgent.toLowerCase();=0A= var uaVer =3D parseInt(navigator.appVersion);=0A= // for detecting netscape 4=0A= var netscape =3D (uaStr.indexOf("mozilla") > -1);=0A= var netscape4 =3D (netscape && uaVer < 5);=0A= =0A= // Get the cookies named "REF_LNX and SRC_LNX"... deprecated for now. = Always set.=0A= // Instead set the hypertext for linking.=0A= //var anchorString =3D ' 3D"extended

3D"extended

';=0A= var anchorString =3D 'Links';=0A= var targString =3D ' target=3D_top';=0A= var anchor2 =3D 'links';=0A= =0A= //NEW for special content linking. Anchor string must be taken from SGML.=0A= var contAnchor =3D '';=0A= =0A= // Linking functions=0A= =0A= =0A= //Get the EarlyView flag of the citing article which is needed to ensure = that the link is suitable for ISI WoS.=0A= // The CONTROL details are passed in, in the form -----. only grab the = 2nd of 5 characters which is the EarlyView flag=0A= function setEarlyView(object)=0A= {=0A= if ((version >=3D 3) && (object.substring(1,2) !=3D "Y"))=0A= {=0A= artEarlyView =3D "EVIEW=3DN"; =0A= }=0A= }=0A= =0A= //Get the DOI of the citing article which is needed for the ISI links.=0A= function setDOI(object){=0A= if (version >=3D 3)=0A= {=0A= artDOI =3D object;=0A= }=0A= }=0A= =0A= function setISSN(object)=0A= {=0A= }=0A= =0A= // Print out the reference link. =0A= function print_link(object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= // remove over-escaped ampersands (ref bugzilla 5515)=0A= var overEscapedAmpersandsRemoved =3D object.replace(new = RegExp('&','g'), '&');=0A= =0A= // remove "BIB" prefix from the value of BIBID (for ISI linking)=0A= // note, this could be performed in LNX. Need to reassess where this = should be done.=0A= var re =3D new RegExp ('BIBID=3DBIB', 'i') ;=0A= var paramstring =3D new String();=0A= paramstring =3D overEscapedAmpersandsRemoved.replace(re, 'BIBID=3D');=0A= =0A= var unpCookie =3D '/cgi-bin/reflink?object=3D' + escape(paramstring = + "&" + artDOI + "&" + artEarlyView + "&" + artEnableISI + "&" + = artTurnOnCas + "&" + artEnablePubMed);=0A= if (netscape4 =3D=3D false)=0A= {=0A= document.write ('' + anchorString + ' ');=0A= }=0A= else // protect against inline style application hanging NN4=0A= {=0A= document.write ('' + = anchorString + ' '); =0A= }=0A= }=0A= else=0A= {=0A= document.writeln();=0A= } =0A= }=0A= =0A= //Print out source links (in the citing article)=0A= function print_SRClink(object){=0A= if (version >=3D 3)=0A= {=0A= var unpCookie =3D '/cgi-bin/srclink?object=3D' + escape(object);=0A= var url =3D unpCookie;=0A= document.write ('

Find = other ');=0A= document.write (anchor2.link(url));=0A= document.write (' for this article.

');=0A= }=0A= else=0A= {=0A= document.writeln();=0A= } =0A= }=0A= =0A= // Links for journal citations=0A= function print_JCIT(object)=0A= {=0A= if (object.match(/JTL/) !=3Dnull)=0A= {=0A= print_link(object); =0A= } =0A= }=0A= =0A= // Links for book citations=0A= function print_BKCIT(object){=0A= }=0A= =0A= // Links for electronic path citations=0A= function print_EPATHCIT(object){=0A= }=0A= =0A= // Links for patent citations=0A= function print_PATENTCIT(object){=0A= }=0A= =0A= // Links for standard citations=0A= function print_STANDARDCIT(object){=0A= }=0A= =0A= // Links for other citations, e.g., theses, proceedings, personal = communications=0A= function print_OTHERCIT(object){=0A= }=0A= =0A= //NEW functions for special content linking. (AID Sept 5 2000)=0A= =0A= // print an anchor with the specified text and calling linking program.=0A= =0A= function print_contentlink_start(conttext, object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= if (object.match(/URL/) !=3D null || object.match(/ACC/) !=3D null)=0A= {=0A= object =3D object + "&TEXT=3D" + conttext;=0A= var unpCookie =3D '/cgi-bin/contlink?object=3D' + escape(object);=0A= document.write ('');=0A= }=0A= }=0A= document.writeln();=0A= =0A= }=0A= =0A= function print_contentlink_end(object)=0A= {=0A= if (version >=3D 3)=0A= {=0A= if (object.match(/URL/) !=3D null || object.match(/ACC/) !=3D null)=0A= {=0A= document.write('');=0A= }=0A= } =0A= document.writeln();=0A= =0A= }=0A= =0A= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/freeflow/js/dcs_tag.js var gService =3D false; var gTimeZone =3D -5; // Code section for Enable First-Party Cookie Tracking function dcsCookie(){ if (typeof(dcsOther)=3D=3D"function"){ dcsOther(); } else if (typeof(dcsPlugin)=3D=3D"function"){ dcsPlugin(); } else if (typeof(dcsFPC)=3D=3D"function"){ dcsFPC(gTimeZone); } } function dcsGetCookie(name){ var cookies=3Ddocument.cookie.split("; "); var cmatch=3D[]; var idx=3D0; var i=3D0; var namelen=3Dname.length; var clen=3Dcookies.length; for (i=3D0;i0){ idx=3D0; if ((cmatchCount>1)&&(typeof(gFpc)!=3D"undefined")&&(name=3D=3DgFpc)){ var dLatest=3Dnew Date(0); for (i=3D0;idLatest){ dLatest.setTime(dLst.getTime()); idx=3Di; } } } return unescape(cmatch[idx].substring(namelen+1)); } else{ return null; } } function dcsGetCrumb(cval,crumb){ var aCookie=3Dcval.split(":"); for (var i=3D0;i(dLst.getTime()+1800000))||(dCur.getTime()>(dSes.getTime= ()+28800000))){ WT.vt_f_tlv=3DMath.floor((dSes.getTime()-adj)/1000); dSes.setTime(dCur.getTime()); WT.vt_f_s=3D"1"; } if = ((dCur.getDay()!=3DdLst.getDay())||(dCur.getMonth()!=3DdLst.getMonth())||= (dCur.getYear()!=3DdLst.getYear())){ WT.vt_f_d=3D"1"; } } WT.co_f=3Descape(WT.co_f); WT.vt_sid=3DWT.co_f+"."+(dSes.getTime()-adj); var expiry=3D"; expires=3D"+dExp.toGMTString(); var cur=3DdCur.getTime().toString(); var ses=3DdSes.getTime().toString(); = document.cookie=3Dname+"=3D"+"id=3D"+WT.co_f+":lv=3D"+cur+":ss=3D"+ses+ex= piry+"; = path=3D/"+(((typeof(gFpcDom)!=3D"undefined")&&(gFpcDom!=3D""))?("; = domain=3D"+gFpcDom):("")); var rc=3DdcsIsFpcSet(name,WT.co_f,cur,ses); if (rc!=3D0){ = WT.co_f=3DWT.vt_sid=3DWT.vt_f_s=3DWT.vt_f_d=3DWT.vt_f_tlh=3DWT.vt_f_tlv=3D= ""; WT.vt_f=3DWT.vt_f_a=3Drc; } } // Code section for Use the new first-party cookie generated with this = tag. function dcsAdv(){ dcsFunc("dcsET"); dcsFunc("dcsCookie"); dcsFunc("dcsAdSearch"); dcsFunc("dcsTP"); } var gImages=3Dnew Array; var gIndex=3D0; var DCS=3Dnew Object(); var WT=3Dnew Object(); var DCSext=3Dnew Object(); var gQP=3Dnew Array(); var gI18n=3Dfalse; if (window.RegExp){ var RE=3DgI18n?{"%25":/\%/g}:{"%09":/\t/g,"%20":/ = /g,"%23":/\#/g,"%26":/\&/g,"%2B":/\+/g,"%3F":/\?/g,"%5C":/\\/g,"%22":/\"/= g,"%7F":/\x7F/g,"%A0":/\xA0/g}; if (gI18n){ var = EXRE=3D/dcs(uri)|(ref)|(aut)|(met)|(sta)|(sip)|(pro)|(byt)|(dat)|(p3p)|(c= fg)|(redirect)|(cip)/i; } } // Add customizations here function dcsVar(){ var dCurrent=3Dnew Date(); WT.tz=3DdCurrent.getTimezoneOffset()/60*-1; if (WT.tz=3D=3D0){ WT.tz=3D"0"; } WT.bh=3DdCurrent.getHours(); = WT.ul=3Dnavigator.appName=3D=3D"Netscape"?navigator.language:navigator.us= erLanguage; if (typeof(screen)=3D=3D"object"){ = WT.cd=3Dnavigator.appName=3D=3D"Netscape"?screen.pixelDepth:screen.colorD= epth; WT.sr=3Dscreen.width+"x"+screen.height; } if (typeof(navigator.javaEnabled())=3D=3D"boolean"){ WT.jo=3Dnavigator.javaEnabled()?"Yes":"No"; } if (document.title){ if (window.RegExp){ var tire=3Dnew = RegExp("^"+window.location.protocol+"//"+window.location.hostname+"\\s-\\= s"); WT.ti=3Ddocument.title.replace(tire,""); } else{ WT.ti=3Ddocument.title; } } WT.js=3D"Yes"; WT.jv=3DdcsJV(); if (document.body&&document.body.addBehavior){ document.body.addBehavior("#default#clientCaps"); WT.ct=3Ddocument.body.connectionType||"unknown"; document.body.addBehavior("#default#homePage"); WT.hp=3Ddocument.body.isHomePage(location.href)?"1":"0"; } else{ WT.ct=3D"unknown"; } if (document.all){ = WT.bs=3Ddocument.body?document.body.offsetWidth+"x"+document.body.offsetH= eight:"unknown"; } else{ WT.bs=3Dwindow.innerWidth+"x"+window.innerHeight; } WT.fi=3D"No"; if (window.ActiveXObject){ for(var i=3D10;i>0;i--){ try{ var flash =3D new ActiveXObject("ShockwaveFlash.ShockwaveFlash."+i); WT.fi=3D"Yes"; WT.fv=3Di+".0"; break; } catch(e){ } } } else if (navigator.plugins&&navigator.plugins.length){ for (var i=3D0;i0){ for (var i=3D0;i'); } } function dcsMeta(){ var elems; if (document.all){ elems=3Ddocument.all.tags("meta"); } else if (document.documentElement){ elems=3Ddocument.getElementsByTagName("meta"); } if (typeof(elems)!=3D"undefined"){ var length=3Delems.length; for (var i=3D0;i0){ if (name.indexOf("WT.")=3D=3D0){ WT[name.substring(3)]=3Dcontent; } else if (name.indexOf("DCSext.")=3D=3D0){ DCSext[name.substring(7)]=3Dcontent; } else if (name.indexOf("DCS.")=3D=3D0){ DCS[name.substring(4)]=3Dcontent; } } } } } function dcsTag(){ if (document.cookie.indexOf("WTLOPTOUT=3D")!=3D-1){ return; } var = P=3D"http"+(window.location.protocol.indexOf('https:')=3D=3D0?'s':'')+":/= /"+gDomain+(gDcsId=3D=3D""?'':'/'+gDcsId)+"/dcs.gif?"; if (gI18n){ WT.dep=3D""; } for (var N in DCS){ if (DCS[N]){ P+=3DdcsA(N,DCS[N]); } } var keys=3D["co_f","vt_sid","vt_f_tlv"]; for (var i=3D0;i0)){ P+=3DdcsA("WT.dep",WT.dep); } if (P.length>2048&&navigator.userAgent.indexOf('MSIE')>=3D0){ P=3DP.substring(0,2040)+"&WT.tu=3D1"; } dcsCreateImage(P); } function dcsJV(){ var agt=3Dnavigator.userAgent.toLowerCase(); var major=3DparseInt(navigator.appVersion); var mac=3D(agt.indexOf("mac")!=3D-1); var ff=3D(agt.indexOf("firefox")!=3D-1); var ff0=3D(agt.indexOf("firefox/0.")!=3D-1); var ff10=3D(agt.indexOf("firefox/1.0")!=3D-1); var ff15=3D(agt.indexOf("firefox/1.5")!=3D-1); var ff2up=3D(ff&&!ff0&&!ff10&!ff15); var = nn=3D(!ff&&(agt.indexOf("mozilla")!=3D-1)&&(agt.indexOf("compatible")=3D=3D= -1)); var nn4=3D(nn&&(major=3D=3D4)); var nn6up=3D(nn&&(major>=3D5)); var ie=3D((agt.indexOf("msie")!=3D-1)&&(agt.indexOf("opera")=3D=3D-1)); var ie4=3D(ie&&(major=3D=3D4)&&(agt.indexOf("msie 4")!=3D-1)); var ie5up=3D(ie&&!ie4); var op=3D(agt.indexOf("opera")!=3D-1); var op5=3D(agt.indexOf("opera 5")!=3D-1||agt.indexOf("opera/5")!=3D-1); var op6=3D(agt.indexOf("opera 6")!=3D-1||agt.indexOf("opera/6")!=3D-1); var op7up=3D(op&&!op5&&!op6); var jv=3D"1.1"; if (ff2up){ jv=3D"1.7"; } else if (ff15){ jv=3D"1.6"; } else if (ff0||ff10||nn6up||op7up){ jv=3D"1.5"; } else if ((mac&&ie5up)||op6){ jv=3D"1.4"; } else if (ie5up||nn4||op5){ jv=3D"1.3"; } else if (ie4){ jv=3D"1.2"; } return jv; } function dcsFunc(func){ if (typeof(window[func])=3D=3D"function"){ window[func](); } } dcsVar(); dcsMeta(); dcsFunc("dcsAdv"); dcsTag(); ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/FIGJS =0A= function newfigwin() {var hwnd =3D window.open('', 'Figures', = 'dependent=3D0,toolbar=3D1,location=3D0,status=3D0,menubar=3D0,scrollbars= =3D1,resizable=3D1,width=3D600,height=3D400'); return hwnd; } =0A= function pagetitle() {return 'Brain Pathology Vol. 19, 4 Pages: = 713-723'; } =0A= function dochead(hwnd, spec) {var title =3D pagetitle(); = hwnd.document.open(); = hwnd.document.write(''+spec+title+''); } =0A= function doctail(hwnd) {hwnd.document.write(''); } =0A= function pagehead(hwnd) {hwnd.document.write('

3D"About

Online ISSN: = 1096-9896 Print ISSN: 0022-3417
The Journal of = Pathology
Volume 214, Issue 3, 2008. Pages: 328-336

Copyright =C2=A9 2007 Pathological Society of Great = Britain and Ireland. Published by John Wiley & Sons, Ltd.

'); } =0A= function copyright(hwnd) {var title =3D pagetitle(); = hwnd.document.write(title.bold() + '
Copyright Journal compilation = © 2009 International Society of Neuropathology

'); } =0A= function imagelink(hwnd, iname) {if (iname.indexOf(' ') > -1) {var = images =3D iname.split(' ');for (var i =3D 0; i < images.length; ++i) = {hwnd.document.write('

');}} = else {hwnd.document.write('

');}}=0A= function otherlinks(hwnd, iname, size) { hwnd.document.write('View List of Images = '); hwnd.document.write('

'); } =0A= =0A= =0A= function caption_f1(hwnd) = {hwnd.document.write('Figure 1. Targeting of glioma by = radiolabeled chimeric monoclonal antibody directed against the EGFRvIII = tumor antigen. (A–C) Planar images of the head and neck obtained = on day 0 (A), day 3 (B), and day 7 (C) after infusion of = ¹¹¹In-ch806. Initial blood pool activity is seen on day 0, = and uptake of ¹¹¹In-ch806 in an anaplastic astrocytoma in the = right frontal lobe is evident by day 3 (arrow) and increases by day 7. = (D–F) Tumor-specific uptake of ¹¹¹In-ch806 (arrow) is = demonstrated in a SPECT image of the brain (D), ¹⁸F-FDG (FDG, = Fluorodeoxyglucose) positron emission tomography (E) and MRI (F). Figure = reproduced with permission from reference (90).'); }=0A= function display_f1(size) { var i =3D new Array(); i[0] =3D 'nf1'; i[1] = =3D 'nf1'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f1', size); imagelink(hwnd, i[size]); = caption_f1(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= function caption_f2(hwnd) = {hwnd.document.write('Figure 2. EGFR downstream = signaling in cancer cells. Figure reproduced with permission from = reference (6).'); }=0A= function display_f2(size) { var i =3D new Array(); i[0] =3D 'nf2'; i[1] = =3D 'nf2'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f2', size); imagelink(hwnd, i[size]); = caption_f2(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= function caption_f3(hwnd) = {hwnd.document.write('Figure 3. Schematic diagram of = the EGFR wild-type protein showing the area of in-frame deletion which = forms EGFRvIII. During the deletion, amino acids 6 and 273 are split = forming a novel glycine at the junction of amino acids 5 and 274. = PEPvIII is a 13 amino acid peptide with a terminal cysteine added to = facilitate conjugation to KLH. Figure reproduced with permission from = reference (85).'); }=0A= function display_f3(size) { var i =3D new Array(); i[0] =3D 'nf3'; i[1] = =3D 'nf3'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f3', size); imagelink(hwnd, i[size]); = caption_f3(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= function caption_f4(hwnd) = {hwnd.document.write('Figure 4. A. High-grade = astrocytoma used in subsequent immunohistochemical assays = (hematoxylin–eosin, original magnification ×400). = B. Antiepidermal growth factor receptor (anti-EGFR) wild-type = immunohistochemistry showing strong diffuse cytoplasmic = immunoreactivity, a pattern that is frequently associated with = EGFR genetic amplification (original magnification ×400). = C. Anti-EGFRvIII immunohistochemical reactivity exhibiting strong = cytoplasmic localization. EGFRvIII immunoreactivity is most commonly = encountered in tumors also exhibiting amplification of the EGFR = locus (original magnification ×400). D. Antiphosphatase = and tensin homolog (anti-PTEN) immunoreactivity demonstrating 80% of = tumor cells with cytoplasmic reactivity, a pattern associated with an = intact PTEN status in the tumor (original magnification ×400). = E. Anti-phospho-S6 immunohistochemistry revealing approximately = 20% of tumor cells labeling, indicating this messenger is activated in = this tumor (original magnification ×400). F. = Anti-phospho-Akt immunohistochemistry demonstrating approximately 80% of = tumor cells labeling, indicating this messenger is activated in this = tumor (original magnification ×400). Figure reproduced with = permission from reference (63).'); }=0A= function display_f4(size) { var i =3D new Array(); i[0] =3D 'nf4'; i[1] = =3D 'nf4'; var hwnd =3D newfigwin(); dochead(hwnd, ''); copyright(hwnd); = otherlinks(hwnd, 'f4', size); imagelink(hwnd, i[size]); = caption_f4(hwnd); doctail(hwnd); hwnd.document.close(); hwnd.focus(); }=0A= =0A= =0A= function imagelist() {var hwnd =3D newfigwin(); dochead(hwnd, 'List of = Images - '); copyright(hwnd); =0A= hwnd.document.write('');=0A= =0A= =0A= hwnd.document.write('');=0A= hwnd.document.write('');=0A= hwnd.document.write('');=0A= hwnd.document.write('');hwnd.document.write('

	'); =0A= caption_f1(hwnd); hwnd.document.write(' [Normal View]

	'); =0A= caption_f2(hwnd); hwnd.document.write(' [Normal View]

	'); =0A= caption_f3(hwnd); hwnd.document.write(' [Normal View]

	'); =0A= caption_f4(hwnd); hwnd.document.write(' [Normal View]

'); doctail(hwnd); = hwnd.document.close(); hwnd.focus(); } ------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/122589692/main.html,ftx_abs Wiley InterScience = :: Article Full Text HTML = setDOI("ADOI=3D10.1111/j.1750-3639.2009.00318.x");<= /SCRIPT>

3D""=20

Brain Pathology

What=20 is RSS?

Volume 19, Issue 4, Pages 713-723

Published Online: 4 Sep 2009

3D"Journal

3D"E-Mail

3D""=20

< Previous Article | Next Article=20 >

Save Article to My Profile=20 Download Citation=20

Abstract | References | Full Text: = HTML , PDF (624k)=20

View Full Width

3D""=20

3D""=20

MINI-SYMPOSIUM: Immunotherapy of = Gliomas

EGFRvIII-Targeted Vaccination Therapy = of=20 Malignant Glioma

Bryan=20 D. Choi, AB ^1,2 = ; Gary E. Archer, PhD=20 ^1,2,4 ; Duane A. Mitchell, MD, PhD ^1,4 = ;=20 Amy B. Heimberger, MD=20 ³ ; Roger E. McLendon, MD ^2,4 = ; Darell D. Bigner, MD, = PhD=20 ^2,4 ; John H. Sampson, MD, PhD, MHSc = ^1,2,4=20

¹ Duke Brain = Tumor=20 Immunotherapy Program, Division of Neurosurgery, Department of = Surgery,=20 Duke University Medical Center, Durham, North Carolina = 27710.=20
= ² Department of = Pathology, Duke University Medical Center, Durham, North Carolina=20 27710.
=20 ³ Department of=20 Neurosurgery, The University of Texas M.D. Anderson Cancer Center, = Houston, Texas 77030.
⁴ The Preston = Robert=20 Tisch Brain Tumor Center, Duke University Medical Center, Durham, = North=20 Carolina 27710.

Correspondence to Bryan = D. Choi, AB,=20 Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery,=20 Department of Surgery, Duke University Medical Center, Durham, = North=20 Carolina 27710 (E-mail: bryan.choi@duke.edu)=20

Copyright Journal compilation =A9 2009 = International Society of Neuropathology

KEYWORDS

antigens =95 central nervous system = neoplasms =95=20 epidermal growth factor receptor =95 immunotherapy

ABSTRACT

3DAbstract=20

Given the highly infiltrative growth pattern of = malignant=20 glioma and the lack of specificity associated with currently = available=20 treatment regimens, alternative strategies designed to eradicate = cancer=20 cells while limiting collateral toxicity in normal tissues remain = a high=20 priority. To this end, the development of specific immunotherapies = against=20 targeted neoplastic cells represents a promising approach.

The epidermal growth factor receptor class III = variant=20 (EGFRvIII), a constitutively activated mutant of the wild-type = tyrosine=20 kinase, is present in a substantial proportion of malignant = gliomas and=20 other human cancers, yet completely absent from normal tissues. = This=20 receptor variant consists of an in-frame deletion, the translation = of=20 which produces an extracellular junction with a novel glycine = residue,=20 flanked by amino acid sequences that are not typically adjacent in = the=20 normal protein.

In this review, both preclinical and early = clinical=20 development of a peptide vaccine directed against this portion of = the=20 EGFRvIII antigenic domain are recapitulated. Following = vaccination, our=20 group has demonstrated potent, redirected cellular and humoral = immunity=20 against cancer cells expressing the mutant receptor without = significant=20 toxicity. Additionally, the corresponding therapeutic outcomes = observed in=20 these studies lend credence to the potential role of peptide-based = vaccination strategies among emerging antitumor immunotherapies in = patients with malignant glioma.

Received 30 June 2009; accepted 30 June=20 2009.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1750-3639.2009.00318.x About=20 DOI

=20

=20

=20

INTRODUCTION

Glioblastoma multiforme (GBM) is the most common = primary=20 malignant brain neoplasm, representing over 50% of all tumors in = this=20 category diagnosed each year (15).=20 It is also one of the most aggressive and difficult cancers to = treat;=20 despite standard multimodal therapy, including surgical resection = and=20 radiotherapy plus temozolomide (TMZ), GBM remains uniformly = lethal, with a=20 median survival of less than 15 months from the time of diagnosis = (96).=20 Recurrent tumors exhibit an even poorer prognosis with a = progression-free=20 survival of less than 20 weeks following currently available = salvage=20 therapy (102).=20 Furthermore, although these outcomes represent remarkable = advancements in=20 the treatment of GBM, conventional strategies are ultimately = limited by=20 significant morbidity associated with nonspecific damage to normal = cells=20 and tissues (47).=20 As a result, there is a clear need for more effective therapies = that=20 enable precise targeting of tumor cells while preserving an = otherwise=20 healthy milieu.

To this end, the immune system has emerged as a = particularly=20 promising approach. Over a century ago, Ehrlich first proposed = that the=20 body's natural immune system, with its inherent specificity and = biologic=20 efficiency, could be redirected to eradicate targeted neoplastic = cells=20 while reducing collateral toxicity (27).=20 It has since been established in numerous studies that proper=20 immunological manipulation, namely via vaccination against tumor = antigens,=20 can result in the regression of even bulky and invasive human = cancers (80).=20 While this type of manipulation has been shown to take many=20 forms=97including cellular, humoral and myriad passive, active and = adoptive=20 strategies=97the discussion continues with regard to the precise = interplay=20 necessary to achieve the greatest antitumor response. This = uncertainty=20 notwithstanding, the prospect of harnessing the discriminatingly = potent=20 nature of the human immune system remains a high priority, and the = understanding of its potential role in the treatment of GBM grows=20 accordingly.

=20

=20

CNS IMMUNOPRIVILEGE

Antitumor immunotherapies, in the context of = intracerebral=20 tumors, encounter a distinct set of challenges, one of the most = prominent=20 being that of central nervous system (CNS) immune privilege. The = first=20 studies to suggest the concept of limited immune surveillance in = the CNS=20 and other select tissues were first reported in 1948 by Sir Peter = Medawar,=20 who showed that allogeneic tissue grafts transplanted into the = brains of=20 experimental animals were not rejected (64).=20 Later research in the area of neuro-immunology would support this = finding=20 based on unique characteristics that are now generally associated = with the=20 CNS: the presence of a specialized blood-brain barrier (BBB) and = the=20 absence of conventional draining lymph nodes as well as resident=20 antigen-presenting cells (APCs) within the brain (30,=20 40).

While the CNS certainly exhibits immune privilege = to some=20 degree, a growing body of data suggests that its isolation from = the immune=20 system is not as complete as once believed. For instance, despite = the BBB,=20 immune cells have been shown to traffic to the brain relatively = frequently=20 (29,=20 44, 74), and, contrary to what was previously thought, antigen = egress=20 via cerebrospinal fluid (CSF) compartments and cervical lymphatics = also=20 appears to occur (19,=20 38). Furthermore, it has been proposed that specialized = microglia (35)=20 along with astrocytes (1)=20 and certain cells of the choroid plexus epithelium (92)=20 are able to mediate human leukocyte antigen (HLA) presentation, = thereby=20 functioning as surrogate APCs within the CNS.

=20

=20

CROSSING THE BBB

As previously mentioned, immune cells, = specifically=20 activated T lymphocytes, have the ability to penetrate the BBB = under=20 normal physiological conditions. This was first appreciated when=20 experimental animals were injected intravenously with = radioactively=20 labeled T cell blasts, which were subsequently tracked to the CNS = (29).=20 Na=EFve T lymphocytes, however, are significantly restricted from = entering=20 the CNS, suggesting that penetration past the BBB is possible only = after=20 activation takes place (65).=20 When it does occur, lymphocyte extravasation into the brain = parenchyma is=20 a highly regulated process mediated by several well-characterized = adhesion=20 molecules and chemotactic factors (29).=20 Once inside the CNS compartment, whether T lymphocytes proliferate = and=20 differentiate within the brain microenvironment has yet to be = established,=20 as previous studies differ on this point; nevertheless, it has = been shown=20 that these cells do remain in the CNS for longer periods of time = if given=20 the opportunity to interact with their cognate antigen (25,=20 62).

Central memory T lymphocytes that alternatively = enter the=20 CNS via the choroid plexus (79)=20 flux continuously throughout subarachnoid spaces, and have = purportedly=20 significant roles in routine CNS immunosurveillance. = Subarachnoid-space=20 macrophages and pericytes associated with CNS microvasculature are = both=20 considered to be critical in the presentation of recall antigens = to this T=20 cell population (29).=20 At any given time, T lymphocytes represent over 80% of the = approximately=20 150 000 cells normally found in the CSF of healthy = individuals (29).=20 As an absolute number, this somewhat diminutive quantity of cells = may not=20 be particularly relevant to immune responses within the brain = parenchyma;=20 however, it seems that these cells are relatively CSF enriched, = given that=20 lymphocytes typically compose less than 5% of all leukocytes = present in=20 circulating blood.

In its intact state, the BBB is thought to be = poorly=20 permeable to antibodies. This assumption stems from the = observation that=20 CSF titers in normal individuals are relatively low, especially in = comparison to those measured in peripheral blood. Generally, the = rate of=20 immunoglobulin diffusion into the CNS varies depending on the = molecular=20 weight of a given protein (75);=20 as an example, the physiological CSF/serum ratios for IgM and IgG = have=20 been quoted to range from 0.005% to 0.025% and 0.16% to 0.32%,=20 respectively, reflecting the difference in size between these = molecules (7).=20 Although these limited ratios undoubtedly evidence CNS immune = privilege to=20 some degree, classic animal experiments have verified that, after = both=20 active and passive immunizations, corresponding antibodies can be = detected=20 within the CNS, specifically the brain, spinal cord and CSF (33).=20 However, the reported fraction eventually isolated from these = areas was=20 again notably small=970.1% to 1% of that found in serum.

The theoretical possibility that even small = amounts of=20 antibody can cross the BBB and have physiologically relevant = effector=20 functions in the CNS is supported by the recent development of = promising=20 vaccines for patients with Alzheimer's disease (AD). These = vaccines target=20 amyloid-β (AB), the cleavage product of amyloid precursor = protein (APP);=20 mutations in which have been shown to lead to parenchymal amyloid = plaque=20 accumulation (39,=20 91) in addition to other pathological features and clinical=20 manifestations of AD (53,=20 60). Initial experiments using transgenic mice expressing = mutant APP=20 have shown that active immunization with the AB peptide reduces = plaque=20 burden and improves behavioral end points (13,=20 51, 88). This provided the first evidence that an immune = response can=20 be used as a potential treatment for AD, in theory by preventing = formation=20 of amyloid deposits and mediating clearance of preexisting = plaques.=20 Subsequent studies confirmed that the therapeutic effects of the = vaccine=20 are, at least in part, due to an antibody-mediated mechanism. This = was=20 primarily demonstrated by animal experiments showing that = peripherally=20 administered AB-specific antibody enters the CNS, localizes to = plaques and=20 achieves amyloid clearance mimicking that observed in previous = mouse=20 studies employing active immunization strategies (3,=20 4). Several hypotheses have been offered regarding the = mechanism=20 behind antibody-mediated plaque clearance in AD (26,=20 94). Of these, one prominent theory states that passively = administered=20 antibody sequesters AB peptide in the periphery without crossing = the BBB,=20 thereby generating a concentration gradient favoring efflux out of = the=20 brain (24).=20 Other suggested antibody mechanisms rely on passage of antibody = across the=20 BBB; these include direct plaque disaggregation (93)=20 and Fc receptor-mediated microglial phagocytosis (4).

Given these conclusions, the concept of BBB = permeability in=20 the absence of frank inflammation appears to be garnering support. = However, it has long been asserted and widely accepted that in the = presence of neuro-inflammatory disease states=97including = experimental=20 autoimmune encephalitis, meningitis and cancer=97the BBB undergoes = changes=20 that alter its ability to block the migration of leukocytes and = serum=20 proteins into the CNS (23).=20 Furthermore, by virtue of their existence, paraneoplastic = syndromes=20 clearly demonstrate that such changes in the BBB occur, and that = these=20 changes are in fact clinically significant. Most paraneoplastic=20 neurological disorders (PND) are likely immune mediated (21),=20 as suggested by the demonstration of antineural antibodies in the = CNS of=20 patients with peripheral tumors. These antibodies represent the = body's=20 natural immune reactivity against systemic tumor antigens, and=20 cross-reactivity with neurological structures has been found to = result in=20 significant morbidity. A number of paraneoplastic antibodies have = been=20 cited in the involvement of PND pathogenesis; these include = anti-Hu,=20 anti-Yo, anti-Ri, anti-CV2/CRMP5, anti-Ma and anti-amphiphysin = antibodies=20 (21).

Because pathological antibodies have been shown to = cross the=20 BBB in the context of malignancy, it follows that peripherally=20 administered therapeutic antibodies should also have access to the = intracerebral environment with physiologically relevant outcomes. = The=20 development of radiolabeled monoclonal antibodies (MAbs) for the = diagnosis=20 and treatment of brain tumors was first explored by Day and = coworkers in=20 1965 (22),=20 and since then, numerous studies have supported that MAbs are = capable of=20 localizing to intracerebral malignancies. Using radioiodinated=20 antitenascin MAb 81C6, our group has shown that not only does 81C6 = exhibit=20 therapeutic activity in mice with intracranial human glioma = xenografts,=20 but that selective tumor localization also occurs in patients with = a=20 variety of intracranial malignancies following peripheral = administration=20 of the antibody (109).=20 However, tumor-specific uptake of 81C6 remained quite low at less = than=20 5 =D7 10⁻³% of the = injected dose per gram,=20 and nonspecific antibody accumulation also took place in other = tissues=20 besides the brain including the liver, spleen and bone marrow. In = contrast=20 to what was observed with 81C6, results from later human studies = using=20 radiolabeled chimeric ch806, a MAb specific for the epidermal = growth=20 factor receptor class III variant (EGFRvIII) tumor antigen, = suggest that=20 higher-percentage BBB penetration may be achieved in the absence = of=20 cross-reactivity with systemic antigens, effectively creating an=20 intracerebral antibody sink at the tumor site (90).=20 Using single-photon emission computed tomography, this potential = effect=20 was observed given the physiological localization of = Indium-111-labeled=20 ch806, which was noted to accumulate within intracranial target = lesions=20 without visual evidence of nonspecific, residual binding in normal = tissues=20 (Figure 1).

=20

= Figure 1. Targeting of = glioma by=20 radiolabeled chimeric monoclonal antibody directed against = the=20 EGFRvIII tumor antigen. (A=96C) Planar images of the head = and neck=20 obtained on day 0 (A), day 3 (B), and day 7 (C) after = infusion of=20 ¹¹¹In-ch806. Initial blood pool = activity is=20 seen on day 0, and uptake of = ¹¹¹In-ch806 in=20 an anaplastic astrocytoma in the right frontal lobe is = evident by=20 day 3 (arrow) and increases by day 7. (D=96F) Tumor-specific = uptake of=20 ¹¹¹In-ch806 (arrow) is demonstrated = in a=20 SPECT image of the brain (D), = ¹⁸F-FDG (FDG,=20 Fluorodeoxyglucose) positron emission tomography (E) and MRI = (F).=20 Figure reproduced with permission from reference (90).=20

[Normal View=20 ]

=20

=20

TUMOR-SPECIFIC REJECTION = ANTIGENS

The landmark paper published over two decades ago = by van Pel=20 and Boon rekindled the then waning interest in cancer vaccine = development=20 when it suggested that even nonimmunogenic tumors display = sufficiently=20 "foreign," and therefore immunologically susceptible antigen = profiles (101).=20 Since that time, a great deal of effort has gone toward = characterizing a=20 variety of human tumor antigens, the majority of which can now be = placed=20 into one of two main categories: those consisting of overexpressed = normal=20 gene products or, alternatively, those derived from mutations in = somatic=20 genes (36,=20 37).

Most well-characterized targeted tumor antigens = isolated to=20 date correspond to overexpressed proteins that are also present in = normal=20 cells, two examples of which include CD20 and erbB2, proteins = associated=20 with lymphoma and breast cancer, respectively. The ability of = antigens in=20 this category to mediate optimal tumor rejection, however, is = often=20 compromised by the fact that proteins that are also found on = normal cells=20 have the potential to trigger immunologic tolerance to varying = degrees.=20 Notable exceptions to this limitation include antigens associated = with=20 fetal gene products, such as carcinoembryonic antigen (50),=20 or those expressed solely in immunoprivileged, tissue-specific = sites like=20 the testes. The latter group includes the melanoma MAGE, GAGE(100),=20 and BAGE (11)=20 family antigens, all of which, due to their limited expression, = trigger=20 little to no tolerance and should therefore make ideal tumor = rejection=20 antigens.

Cancer vaccination protocols that effectively = target normal=20 gene products invariably pose the risk of autoimmune toxicity (37).=20 This untoward effect can be avoided to some extent by directing = the immune=20 response against a mutated protein specific only to tumor cells. = As=20 targets, these antigens have the advantage of avoiding central = tolerance=20 mechanisms, in theory, making them more suitable for tumor = rejection.=20 However, a limitation of these antigens is that they are generally = patient=20 specific as they often reflect random mutations associated with = the=20 inherent genetic instability of tumors (56,=20 59). Thus, to the extent that mutated gene products are = incidental to=20 the oncogenic process, they are conceivably restricted in their = use as=20 practical targets of widely applicable cancer vaccines. = Conversely,=20 although the majority of somatic mutations in tumors does appear = to be=20 sporadic (57),=20 recent studies using high-throughput screening have suggested that = several=20 functional mutations associated with, rather than incidental to, = the=20 oncogenic process are, in fact, not random, and that these = variants are=20 consistently shared among patients (98).=20 The challenge, then, is to isolate and target these ideal = antigens:=20 frequent, highly specific, oncogenic mutations that are also = absent from=20 normal tissues, thereby avoiding the risk of autoimmunity. To = date, few=20 such antigens are known, although their discovery represents a = potential=20 boon for the further development of effective antitumor=20 immunotherapies.

=20

=20

EGFRVIII TUMOR-SPECIFIC = ANTIGEN

Among the many antigens that have been shown to be = overexpressed on tumor cells, the type I epidermal growth factor = receptor=20 (EGFR) represents one of the most frequently implicated = cell-surface=20 markers for a wide range of human malignancies. Functionally, the = EGFR has=20 well-characterized roles in oncogenesis and tumor progression, and = as=20 such, amplification and overexpression of the EGFR=20 gene is considered a poor prognostic indicator (72).=20 Regarding intracerebral cancers in particular, the EGFR gene is amplified in up to 50% and = overexpressed in=20 over 90% of GBM specimens (28,=20 49), suggesting significantly augmented cellular activity of = this=20 receptor in these tumors.

The EGFR is a 170-kDa transmembrane glycoprotein, = consisting=20 of an extracellular ligand-binding domain and an intracellular = region with=20 tyrosine kinase functionality (95).=20 Activation via stimulatory interactions with growth = factors=97including=20 epidermal growth factor (EGF) and transforming growth = factor-α=97results in=20 receptor dimerization and subsequent intracellular = autophosphorylation on=20 tyrosine residues, in turn leading to the activation of downstream = molecules associated with cellular mitogenesis and survival (Figure 2)=20 (14).=20 Given the nature of these potentially oncogenic pathways, it was=20 originally believed that the impact of EGFR on neoplastic = processes was=20 exclusively due to amplification of its corresponding gene. = However, it is=20 now clear that many tumors, including GBM, also express = rearranged,=20 aberrant forms of the EGFR gene that have = significant=20 physiological relevance (28,=20 32). Several of these mutations have been reported in the = literature=20 and are typically associated with tumors that also exhibit = extensive=20 wild-type gene amplification (58,=20 107).

=20

= Figure 2. EGFR=20 downstream signaling in cancer cells. Figure reproduced with = permission from reference (6).=20

[Normal View=20 ]

The most common and well-characterized EGFR mutant was first identified in primary human = GBM=20 tumors and is commonly referred to as the EGFR class III variant=20 (EGFRvIII). EGFRvIII is a constitutively active, = ligand-independent form=20 of the EGF wild-type receptor (5,=20 45), the expression of which has been shown to have = tumorigenic=20 effects, both augmenting proliferation and inhibiting apoptosis (5,=20 73). Specifically, EGFRvIII has also been shown to promote = greater=20 cellular motility (12,=20 76) as well as resistance to radiation and chemotherapy (54,=20 55, 68), characteristics often associated with highly = malignant=20 tumors.

A number of molecular mechanisms have been = implicated in the=20 oncogenic pathways coupled with EGFRvIII downstream signaling. In = the=20 absence of ligand binding and dimerization, for example, EGFRvIII = has been=20 observed to constitutively interact with adaptor proteins central = to the=20 Ras cascade (17,=20 77). Similarly, growth advantage in cells expressing EGFRvIII = has been=20 attributed at least in part to elevated phosphatidylinositol (PI) = 3-kinase=20 levels and consequent activation of the c-Jun N-terminal kinase = pathway (2,=20 70). The respective involvement of, and interplay among, these = signals=20 in neoplastic processes have yet to be fully described; however, = it has=20 been shown that malignant cells become dependent on these pathways = to some=20 extent, and that removal of such stimulation results in reduced = cell=20 survival (103).

Structurally, EGFRvIII is an 801 base pair = in-frame deletion=20 of the wild-type receptor that corresponds to mRNA exons 2=967, = the absence=20 of which leads to the translation of a truncated extracellular = domain (Figure 3).=20 A consequence of this deletion=96mutation is the fusion of two = otherwise=20 distant portions of the molecule, which in turn creates an = antigenic=20 junction characterized by a novel glycine residue, flanked by = amino acid=20 sequences that are not typically adjacent in the wild-type = receptor (10,=20 58). This tumor-specific epitope has been shown to be present = on the=20 surface tumor cells, yet completely absent from any normal adult = tissues=20 (46).

=20

= Figure 3. Schematic = diagram of the=20 EGFR wild-type protein showing the area of in-frame deletion = which=20 forms EGFRvIII. During the deletion, amino acids 6 and 273 = are split=20 forming a novel glycine at the junction of amino acids 5 and = 274.=20 PEPvIII is a 13 amino acid peptide with a terminal cysteine = added to=20 facilitate conjugation to KLH. Figure reproduced with = permission=20 from reference (85).=20

[Normal View=20 ]

Immunohistochemical (IHC) analysis represents one = of the=20 most common assays used to identify the EGFRvIII mutant along with = a=20 number of second messenger molecules also expressed in malignant = cells (Figure 4).=20 Alternative approaches to IHC which employ molecular techniques = such as=20 Western blotting and reverse transcription-polymerase chain = reaction=20 assays are currently being explored and have confirmed the = specific=20 expression of EGFRvIII in human GBM specimens; to date, data = derived from=20 IHC studies have been shown to be consistent with results obtained = using=20 other methods (31).=20 As evidenced by IHC, EGFRvIII is consistently expressed in a wide = variety=20 of cancers, and can be found in approximately 20% of GBM specimens = (69).=20 Within such tumor samples, the proportion of EGFRvIII-expressing = cells has=20 been shown to range from 37% to 86% (105),=20 suggesting that cells within EGFRvIII-positive tumors may = translate the=20 variant receptor with at least some level of homogeneity. Thus, = given its=20 oncogenic properties, inherent tumor specificity and frequent = expression=20 in malignancy, the EGFRvIII mutation represents a particularly = attractive=20 tumor-specific target for the development of anticancer = immunotherapies (52,=20 106).

=20

= Figure 4. A. High-grade astrocytoma used in = subsequent=20 immunohistochemical assays (hematoxylin=96eosin, original=20 magnification =D7400). B. = Antiepidermal growth=20 factor receptor (anti-EGFR) wild-type immunohistochemistry = showing=20 strong diffuse cytoplasmic immunoreactivity, a pattern that = is=20 frequently associated with EGFR = genetic=20 amplification (original magnification =D7400). C.=20 Anti-EGFRvIII immunohistochemical reactivity exhibiting = strong=20 cytoplasmic localization. EGFRvIII immunoreactivity is most = commonly=20 encountered in tumors also exhibiting amplification of the = EGFR locus (original magnification =D7400). = D. Antiphosphatase and tensin homolog = (anti-PTEN)=20 immunoreactivity demonstrating 80% of tumor cells with = cytoplasmic=20 reactivity, a pattern associated with an intact PTEN status = in the=20 tumor (original magnification =D7400). E.=20 Anti-phospho-S6 immunohistochemistry revealing approximately = 20% of=20 tumor cells labeling, indicating this messenger is activated = in this=20 tumor (original magnification =D7400). F.=20 Anti-phospho-Akt immunohistochemistry demonstrating = approximately=20 80% of tumor cells labeling, indicating this messenger is = activated=20 in this tumor (original magnification =D7400). Figure = reproduced with=20 permission from reference (63).=20

[Normal View=20 ]

=20

=20

NATURE OF THE PEPTIDE VACCINE

Generally, immunotherapy can be divided into = either active=20 or passive approaches (81).=20 Active immunizations rely on the natural immune system to mount=20 physiological responses against specific antigens that are either=20 inoculated directly into the body or are instead presented on = autologous=20 APCs. Prior to vaccination, APCs are pulsed with the appropriate = antigen,=20 cancer cells or lysates thereof, and are thereby loaded with the=20 immunogenic material of interest. Passive vaccination strategies = involve=20 either the direct infusion of antibodies or, alternatively, the = adoptive=20 transfer of antigen-specific T lymphocytes.

Currently, a number of immunotherapeutic = approaches=20 targeting the unique EGFRvIII antigen are under investigation. = Given the=20 technical difficulty and relatively high cost of dendritic cell = (DC)=20 vaccination therapy, the most promising and practical active = vaccination=20 format to date is a peptide derived from the novel fusion junction = amino=20 acid sequence. PEPvIII=20 (H-Leu-Glu-Glu-Lys-Lys-Gln-Asn-Tyr-Val-Val-Thr-Asp-His-Cys-OH) (71)=20 is a well-characterized, EGFRvIII-specific, 14-mer peptide that = has been=20 shown, when coupled to keyhole limpet hemocyanin (KLH), to elicit = both=20 humoral and cellular immune responses. Our group has extensive = experience=20 with PEPvIII-KLH, and we have clearly demonstrated the induction = of=20 considerable EGFRvIII-specific immune responses in both murine = tumor=20 models and early clinical trials.

=20

=20

EGFRVIII: PRECLINICAL STUDIES

Our group has shown that passive administration of = EGFRvIII-specific antibodies Y10 and L8A4 (unarmed murine=20 IgG_2a and IgG₁,=20 respectively) leads to significant tumor growth inhibition in = subcutaneous=20 murine melanoma models. These studies, which use syngeneic tumors=20 transfected with a murine homolog of the variant receptor = (msEGFRvIII),=20 have shown that while these two MAbs achieve therapeutic efficacy = when=20 given intraperitoneally, only those mice treated with Y10 exhibit = lasting=20 tumor-free survival after treatment is discontinued (83).=20 Evidence from in vitro studies suggests = that Y10 has=20 the ability to mediate a wide range of effector functions when = incubated=20 with cells expressing msEGFRvIII. These functions include the = inhibition=20 of DNA synthesis and cellular proliferation, as well as the = activation of=20 autologous, complement-mediated and antibody-dependent = cell-mediated=20 cytotoxicity.

Active vaccination strategies targeted against = msEGFRvIII in=20 syngeneic murine tumor models have also been proven to be = effective.=20 Following intraperitoneal injection with DCs pulsed with = PEPvIII-KLH, C3H=20 mice that had previously been challenged with intracerebral tumors = demonstrated a significant increase in median survival. = Furthermore, all=20 the mice in this study survived rechallenge with tumor, suggesting = that=20 immunization was sufficient to create long-term immunological = memory=20 against the msEGFRvIII antigen in this model system (42).=20 Following this experiment, we conducted a similar study in which = C3H mice=20 were treated using a one-time vaccination, this time with = PEPvIII-KLH in=20 complete Freund's adjuvant as opposed to the DC vaccine. This = vaccine=20 protocol also resulted in increased median survival and, = ultimately,=20 long-term survival in nearly half of the mice (43).=20 Notably, mice with tumors that failed to exhibit responses to the=20 PEPvIII-KLH vaccine were found to have IHC evidence of = down-regulated or=20 completely absent EGFRvIII expression, suggesting that antigen = escape=20 variants may be associated with failure to adequately treat some=20 tumors.

=

=20

EGFRVIII: CLINICAL STUDIES

Our group has also demonstrated, in clinical = trials,=20 induction of EGFRvIII-specific immunity with vaccines targeted = against the=20 EGFRvIII tumor-specific antigen. A number of EGFRvIII-derived = cytotoxic T=20 lymphocyte epitopes have been characterized to date (108),=20 and previous data have shown that EGFRvIII-specific antibody = titers, while=20 absent in normal volunteers, may be detectable in patients with = tumors=20 expressing the mutant receptor (78).=20 It is still unclear, however, whether cellular or humoral = responses will=20 ultimately provide the critical mediators for specific antitumor=20 eradication using our approach.

Our first clinical study evaluating the toxicity = and=20 potential efficacy of EGFRvIII-based vaccinations began with a = Phase I=20 trial (VICTORI) (86)=20 conducted at Duke University Medical Center (PI: John H. = Sampson).

Fifteen adults with newly diagnosed GBM (WHO grade = III or=20 IV) were enrolled in the study; criteria for eligibility did not = include=20 EGFRvIII expression. Of the 15 patients, three did not ultimately = receive=20 vaccine due to progression of their tumors during external beam=20 radiotherapy (EBRT). Following gross-total tumor resection and = completion=20 of EBRT, 12 patients underwent leukapheresis to obtain peripheral = blood=20 mononuclear cells in preparation for DC generation and immunologic = monitoring. Prior to inoculation, DCs were pulsed for 2 hours with = 500 =B5g PEPvIII peptide (Anaspec, San Jose, CA, USA) = conjugated to KLH=20 (Biosyn, Carlsbad, CA, USA). In total, patients received up to=20 1.1 =D7 10⁸ DCs in three equal = doses,=20 injected intradermally every 2 weeks into the upper thigh, = 10 cm=20 below the inguinal ligament. Patients were followed for toxicity = and=20 evidence of radiographic or clinical progression.

Patients in the VICTORI trial did not suffer = serious adverse=20 events exceeding Grade II toxicity at any DC dose tested (National = Cancer=20 Institute Common Toxicity Criteria). Blood drawn from patients = following=20 vaccination showed ex vivo evidence of=20 antigen-specific cellular and humoral immune responses. Median = survival=20 for the 12 patients was 18.7 months after vaccination=20 (CI₉₅ 14.5, 25.6) and 22.8 months after=20 histological diagnosis (CI₉₅ 17.5, 29). = These=20 outcomes improve on what would have been expected by chance, = according to=20 Curran's recursive partition analysis (20).=20 Eight of the 12 patients in this study belonged to group III, and = the=20 remaining four belonged to group IV, which have estimated = survivals of=20 17.9 and 11.1 months, respectively. While nine of the 12 patients = in our=20 study surpassed these estimates, the increase in survival was not=20 statistically significant (P =3D 0.083;=20 binomial proportions), although these results may be negatively = biased by=20 the fact that EGFRvIII expression was not a criterion for = inclusion in=20 this Phase I toxicity trial.

Nevertheless, the outcomes associated with our = DC-based,=20 PEPvIII-specific vaccine were encouraging and warranted further = testing at=20 different centers; however, the inherent cost and variability = associated=20 with autologous DC manufacturing made this approach impractical on = a large=20 scale. Thus, given the success of our preclinical studies, we = decided to=20 proceed with a Phase II multicenter trial (ACTIVATE) (41)=20 without the use of DCs, instead administering PEPvIII-KLH directly = in=20 combination with granulocyte macrophage-colony stimulating factor=20 (GM-CSF).

ACTIVATE, a Phase II, multicenter clinical trial = conducted=20 at Duke (PI: John H. Sampson) and University of Texas, M.D. = Anderson=20 Cancer Center (PI: Amy B. Heimberger), enrolled 19 adults who all = had=20 EGFRvIII-expressing, newly diagnosed primary GBM (WHO Grade IV). = Prior to=20 receiving the KLH-conjugated peptide vaccines, patients underwent = >95%=20 volumetric tumor resection, along with standard of care radiation = therapy=20 with concurrent TMZ. Vaccinations consisted of intradermal = injections with=20 500 =B5g PEPvIII-KLH (Anaspec) and GM-CSF, administered near = the=20 inguinal region in the upper thigh, on alternating sides. The = first three=20 vaccines were given biweekly, followed by monthly injections until = radiographic evidence of tumor progression or death.

Similar to what was observed in VICTORI, patients=20 participating in ACTIVATE did not experience serious adverse = events aside=20 from local reactions at the injection site. We demonstrated that = this=20 vaccine formulation elicits both humoral (89)=20 and delayed-type hypersensitivity immune responses specific for = PEPvIII=20 and EGFRvIII in a number of patients, and that detection of these=20 responses predicts greater median overall survival (OS). Median=20 time-to-progression (TTP) following surgery in patients who = received the=20 vaccine is 12 months (n =3D 12), exceeding a median TTP = of 7.1=20 months (n =3D 29) calculated from a historical matched=20 unvaccinated control group (P =3D 0.0058). If=20 and when tumors recurred, pathological samples were obtained and = evaluated=20 by IHC to determine EGFRvIII expression. Of the specimens examined = in this=20 trial, none were found to contain cells that display positive = staining for=20 EGFRvIII.

Following ACTIVATE, our lab initiated the ACT II = trial (84),=20 which enrolled a total of 21 patients who essentially followed the = same=20 treatment scheme as those in ACTIVATE, except for the addition of = two=20 different TMZ dosing schedules concurrent with vaccination cycles; = patients either received 200 mg/m²=20 TMZ =D7 5/28 days [ACT IIA (n =3D 13)] or=20 100 mg/m² TMZ =D7 21/28 = days [ACT IIB=20 (n =3D 8)]. While grade 2 TMZ-associated lymphopenia was = observed=20 in the majority of ACT II patients, we found that all immune = responses=20 were unexpectedly either sustained or enhanced with successive TMZ = treatments. The seemingly paradoxical relationship between = TMZ-induced=20 lymphopenia and improved PEPvIII-KLH-specific immunogenicity is = currently=20 under further investigation.

In summary, these trials to date collectively show = that=20 vaccination with a peptide containing the PEPvIII tumor epitope = safely=20 elicits a specific immune response against EGFRvIII, and that this = approach might be effective against cancers bearing the variant = antigen.=20 While our group has demonstrated significantly greater TTP and OS = in GBM=20 patients who have received the PEPvIII-KLH vaccine, definitive = evidence=20 for this promising effect will require confirmation from our = ongoing=20 randomized Phase III clinical trials.

=20

=20

DISCUSSION

While the mechanisms underlying the beneficial = effects of=20 our vaccine in patients with GBM are still unclear, it is our hope = that=20 additional experience with PEPvIII-KLH will elucidate our general=20 understanding of various peptide vaccination strategies and their=20 potential role in eliciting effective antitumor responses. = Previous trials=20 employing peptide vaccines have targeted a wide range of cancers = including=20 those of the colon, prostate, breast, cervix, pancreas and = ovaries. The=20 most convincing evidence in favor of peptide vaccine efficacy = comes from=20 the melanoma literature, in which a number of tumor-associated = antigens=20 have been specifically targeted with relative success, some of = which=20 include MART-1 (16),=20 MAGE-3 (61),=20 tyrosinase (87),=20 and NY-ESO-1 (48).=20 Data from many early clinical vaccine trials for melanoma and = other=20 neoplasms have been fairly encouraging, although some have claimed = that=20 these results have been overly optimistic due to a reliance on = subjective=20 or "soft" end points. In 2004, Rosenberg et al suggested that = criteria for clinical responses to cancer vaccines should only = include=20 objective measurements such as those denoting tumor size and = volume.=20 Taking these new parameters into account, he reassessed 35 = National Cancer=20 Institute trials involving a wide range of cancers and concluded = that=20 overall, there were only seven objective tumor responses out of a = total of=20 175 patients (4%) who had received some form of peptide vaccine. = At that=20 time, the implications of these results could not be understated, = and thus=20 represented a turning point for the field of cancer immunotherapy. = However, the conclusions drawn by Rosenberg and colleagues have = since been=20 challenged as excessively pessimistic and potentially misleading = (67,=20 99). Opposing views suggest that the literature instead = supports more=20 favorable tumor response rates (10%) following treatment with = peptide=20 vaccines, and that this frequency may even be higher when = employing the=20 objective criteria as mandated by Response Evaluation Criteria in = Solid=20 Tumors (97).=20 In addition, it was brought to attention that many patients = receive=20 vaccinations only after completion of standard chemotherapeutic = regimens,=20 conceivably making their tumors more aggressive and resistant to = treatment=20 when compared with those who had not received therapy. Finally, it = has=20 been suggested that a number of immunological variables (eg, = adjuvants,=20 HLA haplotypes) have yet to be explored in the context of peptide=20 vaccines, knowledge of which might ultimately improve efficacy of = existing=20 therapeutic regimens. Regardless of the ongoing discussion on the = future=20 of active cancer vaccination strategies, Rosenberg et al and = other=20 authors agree that, at this stage, it would be unwise to interpret = any=20 lack of clinical evidence as an "investigational dead end," = insofar as=20 present shortcomings may simply reflect the need for further = exploration=20 (82).

As the field of tumor immunology moves forward, in = addition=20 to the standardization of and adherence to objective end points, = there are=20 still a number of issues regarding the specific targeting of = cancer=20 epitopes by peptide vaccines that must be addressed. It is known, = for=20 example, that although a variety of tumors including malignant = glioma have=20 been found to express the EGFRvIII mutation, cells within these = cancers=20 often exhibit significant antigenic heterogeneity (8,=20 9, 104, 105). This confounds immunotherapeutic approaches = designed to=20 target single tumor-specific antigens, as even effective vaccines = will=20 fail to target those cells in the tumor that do not happen to = express a=20 given epitope. We observed the potential consequences of this = issue in=20 both murine studies (43)=20 and clinical trials, in which the majority of recurrent tumors = from=20 vaccinated patients no longer expressed EGFRvIII. Thus, in the = context of=20 cancer vaccines, greater antitumor effects may be achieved with = the=20 development of multiantigenic vaccines that target the various = aberrant=20 biological processes often present in GBM and other tumors (34);=20 the recently characterized expression of human cytomegalovirus = antigens in=20 GBM, for instance, may provide multiple targets for such an = approach (18,=20 66). Alternatively, strategies that enrich EGFRvIII-positive = cell=20 populations prior to treatment may also prove to increase = antitumor=20 efficacy.

GBM is a devastating disease, and despite recent = advances in=20 antitumor therapy, there is still a pressing need for novel and = effective=20 approaches designed to potently eradicate tumor cells while = minimizing=20 toxicity to neighboring tissues. The potential ability to harness = and=20 redirect the cytotoxic power and inherent specificity of the = immune system=20 against neoplastic cells provides one such approach. As reviewed = herein,=20 our lab has shown that peptide vaccines can be employed to safely = generate=20 both B and T cell-mediated immune responses against tumor-specific = epitopes such as the EGFRvIII antigen. Moreover, we have = demonstrated that=20 these responses are efficacious in murine models, and that similar = therapeutic outcomes may be expected in humans with malignant = glioma, even=20 in the context of severe immunosuppression.

=20

=20

=20

REFERENCES

1.
Aloisi F, Ria F, Adorini L (2000)=20 Regulation of T-cell = responses by=20 CNS antigen-presenting cells: different roles for microglia and=20 astrocytes. Immunol = Today 21:141=96147.
2.
Antonyak MA,=20 Moscatello DK, Wong AJ (1998)=20 Constitutive activation = of c-Jun=20 N-terminal kinase by a mutant epidermal growth factor = receptor.=20 J Biol Chem 273:2817=962822.
3.
Bacskai BJ,=20 Kajdasz ST, Christie RH,=20 Carter C, Games D, Seubert P=20 et al (2001) Imaging of amyloid-beta = deposits in=20 brains of living mice permits direct observation of clearance of = plaques=20 with immunotherapy. Nat=20 Med 7:369=96372.
4.
Bard F, Cannon C, Barbour R,=20 Burke RL, Games D, Grajeda H=20 et al (2000) Peripherally administered = antibodies=20 against amyloid beta-peptide enter the central nervous system = and reduce=20 pathology in a mouse model of Alzheimer disease. Nat Med 6:916=96919.
5.
Batra SK, Castelino-Prabhu S, Wikstrand CJ,=20 Zhu X, Humphrey PA,=20 Friedman HS, Bigner DD (1995)=20 Epidermal growth factor=20 ligand-independent, unregulated, cell-transforming potential of = a=20 naturally occurring human mutant EGFRvIII gene. Cell Growth Differ 6:1251=961259.
6.
Bianco R, Gelardi T, Damiano V,=20 Ciardiello F, Tortora G (2007)=20 Rational bases for the = development=20 of EGFR inhibitors for cancer treatment. Int J Biochem Cell Biol = 39:1416=961431.
7.
Bickel U (1995)=20 Antibody delivery through = the=20 blood-brain barrier. Adv Drug=20 Deliv Rev 15:53=9672.
8.
Bigner DD (1981)=20 Biology of gliomas: = potential=20 clinical implications of glioma cellular heterogeneity. = Neurosurgery 9:320=96326. =
9.
Bigner DD,=20 Schold C, Bigner SH,=20 Bullard DE, Wikstrand C=20 (1981) How heterogeneous are = gliomas?=20 Cancer Treat Rep = 65(Suppl. 2):45=9649.
10.
Bigner SH,=20 Humphrey PA, Wong AJ, Vogelstein B, Mark J, Friedman HS, Bigner DD (1990)=20 Characterization of the = epidermal=20 growth factor receptor in human glioma cell lines and = xenografts.=20 Cancer Res 50:8017=968022.
11.
Boel P, Wildmann C, Sensi ML, Brasseur R, Renauld JC,=20 Coulie P=20 et al (1995) BAGE: a new gene encoding an = antigen=20 recognized on human melanomas by cytolytic T lymphocytes. = Immunity 2:167=96175.
12.
Boockvar JA,=20 Kapitonov D, Kapoor G, Schouten J, Counelis GJ,=20 Bogler O=20 et al (2003) Constitutive EGFR signaling = confers a=20 motile phenotype to neural stem cells. Mol Cell Neurosci 24:1116=961130.
13.
Brendza RP,=20 Holtzman DM=20 (2006) Amyloid-beta immunotherapies in = mice and=20 men. Alzheimer Dis = Assoc=20 Disord 20:118=96123.
14.
Carpenter G,=20 Cohen S=20 (1990) Epidermal growth factor. = J Biol Chem 265:7709=967712.
15.
CBTRUS = (2008) Statistical report: primary = brain tumors=20 in The United States, 2000=962004. Published by The Central Brain Tumor Registry of = The United=20 States.
16.
Cebon J, Jager E, Shackleton MJ,=20 Gibbs P, Davis ID, Hopkins W=20 et al (2003) Two phase I studies of low dose = recombinant human IL-12 with Melan-A and influenza peptides in = subjects=20 with advanced malignant melanoma. Cancer Immun 3:7.
17.
Chu CT, Everiss KD, Wikstrand CJ,=20 Batra SK, Kung HJ, Bigner DD=20 (1997) Receptor dimerization is not a = factor in=20 the signalling activity of a transforming variant epidermal = growth=20 factor receptor (EGFRvIII). Biochem J 324:855=96861.
18.
Cobbs CS, Harkins L, Samanta M,=20 Gillespie GY, Bharara S,=20 King PH=20 et al (2002) Human cytomegalovirus infection = and=20 expression in human malignant glioma. Cancer Res 62:3347=963350.
19.
Cserr HF, Knopf PM=20 (1992) Cervical lymphatics, the = blood-brain=20 barrier and the immunoreactivity of the brain: a new = view. Immunol Today 13:507=96512.
20.
Curran WJ = Jr, Scott CB, Horton J, Nelson JS,=20 Weinstein AS, Fischbach AJ=20 et al (1993) Recursive partitioning analysis = of=20 prognostic factors in three Radiation Therapy Oncology Group = malignant=20 glioma trials. J = Natl Cancer=20 Inst 85:704=96710.
21.
Dalmau J, Rosenfeld MR=20 (2008) Paraneoplastic syndromes of the = CNS. Lancet = Neurol=20 7:327=96340.
22.
Day ED, Lassiter S, Woodhall B,=20 Mahaley JL, Mahaley MS = Jr=20 (1965) The localization of = radioantibodies in=20 human brain tumors. I. Preliminary exploration. Cancer Res 25:773=96778.
23.
de Vries HE,=20 Kuiper J, de=20 Boer AG, Van Berkel TJ, Breimer DD (1997)=20 The blood-brain barrier = in=20 neuroinflammatory diseases. Pharmacol Rev 49:143=96155.
24.
DeMattos RB,=20 Bales KR, Cummins DJ,=20 Dodart JC, Paul SM, Holtzman DM=20 (2001) Peripheral anti-A beta antibody = alters=20 CNS and plasma A beta clearance and decreases brain A beta = burden in a=20 mouse model of Alzheimer's disease. Proc Natl Acad Sci USA = 98:8850=968855.
25.
Deshpande SS,=20 Angkeow P, Huang J, Ozaki M, Irani K (2000)=20 Rac1 inhibits = TNF-alpha-induced=20 endothelial cell apoptosis: dual regulation by reactive oxygen=20 species. FASEB = J 14:1705=961714.
26.
Duff K (1999)=20 Curing amyloidosis: will = it work in=20 humans? Trends=20 Neurosci 22:485=96486.
27.
Ehrlich P,=20 Bolduan C=20 (1906) Collected Studies on = Immunity, 1st edn. J. Wiley & Sons: New York.
28.
Ekstrand AJ,=20 James CD, Cavenee WK,=20 Seliger B, Pettersson RF,=20 Collins VP=20 (1991) Genes for epidermal growth = factor=20 receptor, transforming growth factor alpha, and epidermal growth = factor=20 and their expression in human gliomas in=20 vivo. Cancer = Res 51:2164=962172.
29.
Engelhardt B,=20 Ransohoff RM=20 (2005) The ins and outs of = T-lymphocyte=20 trafficking to the CNS: anatomical sites and molecular=20 mechanisms. Trends=20 Immunol 26:485=96495.
30.
Fabry Z, Raine CS, Hart MN (1994)=20 Nervous tissue as an = immune=20 compartment: the dialect of the immune response in the = CNS. Immunol Today 15:218=96224.
31.
Feldkamp MM,=20 Lala P, Lau N, Roncari L, Guha A (1999)=20 Expression of activated = epidermal=20 growth factor receptors, Ras-guanosine triphosphate, and=20 mitogen-activated protein kinase in human glioblastoma = multiforme=20 specimens. Neurosurgery 45:1442=961453.
32.
Frederick L,=20 Wang XY, Eley G, James CD=20 (2000) Diversity and frequency of = epidermal=20 growth factor receptor mutations in human glioblastomas. = Cancer Res 60:1383=961387.
33.
Freund J (1930)=20 Accumulation of = antibodies in the=20 central nervous system. J Exp=20 Med 51:889=96902.
34.
Furnari FB,=20 Fenton T, Bachoo RM,=20 Mukasa A, Stommel JM,=20 Stegh A=20 et al (2007) Malignant astrocytic glioma: = genetics,=20 biology, and paths to treatment. Genes Dev 21:2683=962710.
35.
Gehrmann J,=20 Matsumoto Y, Kreutzberg GW=20 (1995) Microglia: intrinsic = immuneffector cell=20 of the brain. Brain = Res Brain=20 Res Rev 20:269=96287.
36.
Gilboa E (1999)=20 The makings of a tumor = rejection=20 antigen. Immunity=20 11:263=96270.
37.
Gilboa E (2004)=20 The promise of cancer=20 vaccines. Nat Rev=20 Cancer 4:401=96411.
38.
Goldmann J,=20 Kwidzinski E, Brandt C, Mahlo J, Richter D,=20 Bechmann I=20 (2006) T cells traffic from brain to = cervical=20 lymph nodes via the cribroid plate and the nasal mucosa. = J Leukoc Biol 80:797=96801.
39.
Hardy J (1997)=20 Amyloid, the presenilins = and=20 Alzheimer's disease. Trends=20 Neurosci 20:154=96159.
40.
Hart DN, Fabre JW=20 (1981) Demonstration and = characterization of=20 Ia-positive dendritic cells in the interstitial connective = tissues of=20 rat heart and other tissues, but not brain. J Exp Med 154:347=96361.
41.
Heimberger A,=20 Hussain SF, Aldape K, Sawaya R, Archer GA,=20 Friedman H=20 et al (2006) Tumor-specific peptide = vaccination in=20 newly-diagnosed patients with GBM. J Clin Oncol 24: abstr 2529.
42.
Heimberger AB,=20 Archer GE, Crotty LE,=20 McLendon RE, Friedman AH,=20 Friedman HS=20 et al (2002) Dendritic cells pulsed with a=20 tumor-specific peptide induce long-lasting immunity and are = effective=20 against murine intracerebral melanoma. Neurosurgery 50:158=96164;=20 discussion = 64=9666.
43.
Heimberger AB,=20 Crotty LE, Archer GE,=20 Hess KR, Wikstrand CJ,=20 Friedman AH=20 et al (2003) Epidermal growth factor = receptor VIII=20 peptide vaccination is efficacious against established = intracerebral=20 tumors. Clin Cancer = Res 9:4247=964254.
44.
Hickey WF (1991)=20 Migration of hematogenous = cells=20 through the blood-brain barrier and the initiation of CNS=20 inflammation. Brain = Pathol 1:97=96105.
45.
Hou ST, Wang CC, Chu ML (1997)=20 Ribotyping and random = amplification=20 of polymorphic DNA for nosocomial Enterobacter=20 cloacae isolates in a pediatric intensive-care = unit. Infect Control Hosp = Epidemiol 18:769=96771.
46.
Humphrey PA,=20 Wong AJ, Vogelstein B,=20 Zalutsky MR, Fuller GN,=20 Archer GE=20 et al (1990) Anti-synthetic peptide antibody = reacting=20 at the fusion junction of deletion-mutant epidermal growth = factor=20 receptors in human glioblastoma. Proc Natl Acad Sci USA = 87:4207=964211.
47.
Imperato JP,=20 Paleologos NA, Vick NA (1990)=20 Effects of treatment on = long-term=20 survivors with malignant astrocytomas. Ann Neurol 28:818=96822.
48.
Jager E, Gnjatic S, Nagata Y, Stockert E, Jager D, Karbach J=20 et al (2000) Induction of primary NY-ESO-1 = immunity:=20 CD8+ T lymphocyte and antibody responses in peptide-vaccinated = patients=20 with NY-ESO-1+ cancers. Proc=20 Natl Acad Sci USA 97:12198=9612203.
49.
Jaros E, Perry RH, Adam L, Kelly PJ, Crawford PJ,=20 Kalbag RM=20 et al (1992) Prognostic implications of p53 = protein,=20 epidermal growth factor receptor, and Ki-67 labelling in brain=20 tumours. Br J = Cancer=20 66:373=96385.
50.
Kass E, Schlom J, Thompson J,=20 Guadagni F, Graziano P,=20 Greiner JW=20 (1999) Induction of protective host = immunity to=20 carcinoembryonic antigen (CEA), a self-antigen in CEA transgenic = mice,=20 by immunizing with a recombinant vaccinia-CEA virus. = Cancer Res 59:676=96683.
51.
Koller MF,=20 Mohajeri MH, Huber M, Wollmer MA, Roth Z'graggen BV, Sandmeier E=20 et al (2004) Active immunization of mice = with an=20 Abeta-Hsp70 vaccine. Neurodegener Dis 1:20=9628.
52.
Kuan CT, Wikstrand CJ, Bigner DD (2001)=20 EGF mutant receptor vIII = as a=20 molecular target in cancer therapy. Endocr Relat Cancer 8:83=9696.
53.
Lahiri DK,=20 Chen DM, Lahiri P, Bondy S, Greig NH (2005)=20 Amyloid, cholinesterase, = melatonin,=20 and metals and their roles in aging and neurodegenerative=20 diseases. Ann N Y = Acad=20 Sci 1056:430=96449.
54.
Lammering G,=20 Hewit TH, Holmes M, Valerie K, Hawkins W,=20 Lin PS=20 et al (2004) Inhibition of the type III = epidermal=20 growth factor receptor variant mutant receptor by = dominant-negative=20 EGFR-CD533 enhances malignant glioma cell = radiosensitivity. Clin Cancer Res 10:6732=966743.
55.
Lammering G,=20 Valerie K, Lin PS, Hewit TH, Schmidt-Ullrich RK=20 (2004) Radiation-induced activation of = a common=20 variant of EGFR confers enhanced radioresistance. Radiother Oncol 72:267=96273.
56.
Lengauer C,=20 Kinzler KW, Vogelstein B=20 (1998) Genetic instabilities in human=20 cancers. Nature 396:643=96649.
57.
Lennerz V,=20 Fatho M, Gentilini C,=20 Frye RA, Lifke A, Ferel D=20 et al (2005) The response of autologous T = cells to a=20 human melanoma is dominated by mutated neoantigens. Proc Natl Acad Sci USA = 102:16013=9616018.
58.
Libermann TA,=20 Nusbaum HR, Razon N, Kris R, Lax I, Soreq H=20 et al (1985) Amplification, enhanced = expression and=20 possible rearrangement of EGF receptor gene in primary human = brain=20 tumours of glial origin. Nature 313:144=96147.
59.
Loeb LA (2001)=20 A mutator phenotype in=20 cancer. Cancer = Res=20 61:3230=963239.
60.
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L=20 et al (1999) Soluble amyloid beta peptide=20 concentration as a predictor of synaptic change in Alzheimer's=20 disease. Am J = Pathol=20 155:853=96862.
61.
Marchand M,=20 van Baren N, Weynants P,=20 Brichard V, Dreno B, Tessier MH=20 et al (1999) Tumor regressions observed in = patients=20 with metastatic melanoma treated with an antigenic peptide = encoded by=20 gene MAGE-3 and presented by HLA-A1. Int J Cancer 80:219=96230.
62.
Masson F, Calzascia T, Di=20 Berardino-Besson W, = de Tribolet N, Dietrich PY,=20 Walker PR=20 (2007) Brain microenvironment promotes = the final=20 functional maturation of tumor-specific effector CD8+ T = cells.=20 J Immunol 179:845=96853.
63.
McLendon RE,=20 Turner K, Perkinson K,=20 Rich J=20 (2007) Second messenger systems in = human=20 gliomas. Arch = Pathol Lab=20 Med 131:1585=961590.
64.
Medawar PB (1948)=20 Immunity to homologous = grafted=20 skin; the fate of skin homografts transplanted to the brain, to=20 subcutaneous tissue, and to the anterior chamber of the = eye.=20 Br J Exp Pathol = 29:58=9669.
65.
Mitchell DA,=20 Fecci PE, Sampson JH (2008)=20 Immunotherapy of = malignant brain=20 tumors. Immunol = Rev=20 222:70=96100.
66.
Mitchell DA,=20 Xie W, Schmittling R,=20 Learn C, Friedman A,=20 McLendon RE, Sampson JH (2008)=20 Sensitive detection of = human=20 cytomegalovirus in tumors and peripheral blood of patients = diagnosed=20 with glioblastoma. Neurooncol 10:10=9618.
67.
Mocellin S,=20 Mandruzzato = S, Bronte V, Marincola FM=20 (2004) Cancer vaccines: pessimism in=20 check. Nat = Med 10:1278=961279;=20 author reply = 9=9680.
68.
Montgomery RB,=20 Guzman J, O'Rourke DM,=20 Stahl WL=20 (2000) Expression of oncogenic = epidermal growth=20 factor receptor family kinases induces paclitaxel resistance and = alters=20 beta-tubulin isotype expression. J Biol Chem 275:17358=9617363.
69.
Moscatello DK,=20 Holgado-Madruga = M, Godwin AK,=20 Ramirez G, Gunn G, Zoltick PW=20 et al (1995) Frequent expression of a mutant = epidermal=20 growth factor receptor in multiple human tumors. Cancer Res 55:5536=965539.
70.
Moscatello DK,=20 Holgado-Madruga = M, Emlet DR, Montgomery RB, Wong AJ (1998)=20 Constitutive activation = of=20 phosphatidylinositol 3-kinase by a naturally occurring mutant = epidermal=20 growth factor receptor. J=20 Biol Chem 273:200=96206.
71.
Moscatello DK,=20 Ramirez G, Wong AJ (1997)=20 A naturally occurring = mutant human=20 epidermal growth factor receptor as a target for peptide vaccine = immunotherapy of tumors. Cancer Res 57:1419=961424.
72.
Neal DE, Sharples L, Smith K, Fennelly J, Hall RR, Harris AL=20 (1990) The epidermal growth factor = receptor and=20 the prognosis of bladder cancer. Cancer 65:1619=961625.
73.
Nishikawa R,=20 Ji XD, Harmon RC,=20 Lazar CS, Gill GN, Cavenee WK, Huang HJ (1994)=20 A mutant epidermal growth = factor=20 receptor common in human glioma confers enhanced = tumorigenicity.=20 Proc Natl Acad Sci = USA 91:7727=967731.
74.
Owens T, Renno T, Taupin V, Krakowski M=20 (1994) Inflammatory cytokines in the = brain: does=20 the CNS shape immune responses? Immunol Today 15:566=96571.
75.
Pardridge WM=20 (1991) Peptide Drug Delivery to the = Brain.=20 Raven Press: New York.
76.
Pedersen MW,=20 Tkach V, Pedersen N,=20 Berezin V, Poulsen HS (2004)=20 Expression of a naturally = occurring=20 constitutively active variant of the epidermal growth factor = receptor in=20 mouse fibroblasts increases motility. Int J Cancer 108:643=96653.
77.
Prigent SA,=20 Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR=20 et al (1996) Enhanced tumorigenic behavior = of=20 glioblastoma cells expressing a truncated epidermal growth = factor=20 receptor is mediated through the Ras-Shc-Grb2 pathway. = J Biol Chem 271:25639=9625645.
78.
Purev E, Cai D, Miller E, Swoboda R, Mayer T, Klein-Szanto A=20 et al (2004) Immune responses of breast = cancer=20 patients to mutated epidermal growth factor receptor (EGF-RvIII, = Delta=20 EGF-R, and de2-7 EGF-R). J=20 Immunol 173:6472=966480.
79.
Ransohoff RM,=20 Kivisakk P, Kidd G (2003)=20 Three or more routes for = leukocyte=20 migration into the central nervous system. Nat Rev Immunol 3:569=96581.
80.
Rosenberg SA=20 (2001) Progress in human tumour = immunology and=20 immunotherapy. Nature=20 411:380=96384.
81.
Rosenberg SA=20 (2004) Shedding light on immunotherapy = for=20 cancer. N Engl J = Med=20 350:1461=961463.
82.
Rosenberg SA,=20 Yang JC, Restifo NP (2004)=20 Cancer immunotherapy: = moving beyond=20 current vaccines. Nat=20 Med 10:909=96915.
83.
Sampson JH,=20 Crotty LE, Lee S, Archer GE, Ashley DM,=20 Wikstrand CJ=20 et al (2000) Unarmed, tumor-specific = monoclonal=20 antibody effectively treats brain tumors. Proc Natl Acad Sci USA = 97:7503=967508.
84.
Sampson JH,=20 Archer GE, Bigner D, Davis T, Friedman HS,=20 Keler T=20 et al (2008) Effect of EGFRvIII-targeted = vaccine=20 (CDX-110) on immune response and TTP when given with = simultaneous=20 standard and continuous temozolomide in patients with = GBM. J Clin Oncol 26: abstr 2011.
85.
Sampson JH,=20 Archer GE, Mitchell DA,=20 Heimberger AB, Bigner DD (2008)=20 Tumor-specific = immunotherapy=20 targeting the EGFRvIII mutation in patients with malignant=20 glioma. Semin = Immunol=20 20(5):267=96275.
86.
Sampson JH,=20 Archer GE, Mitchell DA,=20 Heimberger A, Herndon JE = 2nd, Lally-Goss D=20 et al (2009) An epidermal growth factor = receptor=20 variant III-targeted vaccine is safe and immunogenic in patients = with=20 glioblastoma multiforme (submitted for = publication).
87.
Scheibenbogen C, Schmittel A,=20 Keilholz U, Allgauer T,=20 Hofmann U, Max R et al (2000) Phase 2 trial of vaccination = with=20 tyrosinase peptides and granulocyte-macrophage = colony-stimulating factor=20 in patients with metastatic melanoma. J Immunother 23:275=96281.
88.
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H,=20 Guido T=20 et al (1999) Immunization with amyloid-beta = attenuates=20 Alzheimer-disease-like pathology in the PDAPP mouse. = Nature 400:173=96177.
89.
Schmittling RJ,=20 Archer GE, Mitchell DA,=20 Heimberger A, Pegram C, Herndon JE=20 et al (2008) Detection of humoral response = in patients=20 with glioblastoma receiving EGFRvIII-KLH vaccines. J Immunol Methods 339:74=9681.
90.
Scott AM, Lee FT, Tebbutt N,=20 Herbertson R, Gill SS, Liu Z=20 et al (2007) A=20 phase I clinical trial with monoclonal antibody ch806 targeting=20 transitional state and mutant epidermal growth factor = receptors.=20 Proc Natl Acad Sci = USA 104:4071=964076.
91.
Selkoe DJ (1999)=20 Translating cell biology = into=20 therapeutic advances in Alzheimer's disease. Nature 399(6738 Suppl.):A23=96A31.
93.
Solomon B,=20 Koppel R, Frankel D,=20 Hanan-Aharon = E=20 (1997) Disaggregation of Alzheimer = beta-amyloid=20 by site-directed mAb. Proc=20 Natl Acad Sci USA 94:4109=964112.
94.
St. George-Hyslop PH, Westaway DA=20 (1999) Alzheimer's disease. Antibody = clears=20 senile plaques. Nature=20 400:116=96117.
95.
Stoscheck CM,=20 King LE Jr (1986)=20 Functional and structural = characteristics of EGF and its receptor and their relationship = to=20 transforming proteins. J Cell=20 Biochem 31:135=96152.
96.
Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ=20 et al (2005) Radiotherapy plus concomitant = and=20 adjuvant temozolomide for glioblastoma. N Engl J Med 352:987=96996.
97.
Therasse P,=20 Arbuck SG, Eisenhauer EA,=20 Wanders J, Kaplan RS,=20 Rubinstein L=20 et al (2000) New guidelines to evaluate the = response=20 to treatment in solid tumors. European Organization for Research = and=20 Treatment of Cancer, National Cancer Institute of the United = States,=20 National Cancer Institute of Canada. J Natl Cancer Inst 92:205=96216.
98.
Thomas RK,=20 Baker AC, Debiasi RM,=20 Winckler W, Laframboise T,=20 Lin WM=20 et al (2007) High-throughput oncogene = mutation=20 profiling in human cancer. Nat Genet 39:347=96351.
99.
Timmerman JM,=20 Levy R=20 (2004) Cancer vaccines: pessimism in=20 check. Nat = Med 10:1279;=20 author reply = 1279=9680.
100.
Van den Eynde B, Peeters O,=20 De Backer O, Gaugler B,=20 Lucas S, Boon T (1995)=20 A new family of genes = coding for an=20 antigen recognized by autologous cytolytic T lymphocytes on a = human=20 melanoma. J Exp = Med=20 182:689=96698.
101.
Van Pel A,=20 Boon T=20 (1982) Protection against a = nonimmunogenic mouse=20 leukemia by an immunogenic variant obtained by = mutagenesis. Proc Natl Acad Sci USA = 79:4718=964722.
102.
Vredenburgh JJ,=20 Desjardins A, Herndon JE = 2nd, Marcello J,=20 Reardon DA, Quinn JA et al (2007) Bevacizumab plus irinotecan in = recurrent=20 glioblastoma multiforme. J=20 Clin Oncol 25:4722=964729.
103.
Weinstein IB=20 (2002) Cancer. Addiction to = oncogenes=97the=20 Achilles heal of cancer. Science 297:63=9664.
104.
Wikstrand CJ,=20 Bigner SH, Bigner DD (1983)=20 Demonstration of complex = antigenic=20 heterogeneity in a human glioma cell line and eight derived = clones by=20 specific monoclonal antibodies. Cancer Res 43:3327=963334.
105.
Wikstrand CJ,=20 McLendon RE, Friedman AH,=20 Bigner DD=20 (1997) Cell surface localization and = density of=20 the tumor-associated variant of the epidermal growth factor = receptor,=20 EGFRvIII. Cancer = Res=20 57:4130=964140.
106.
Wikstrand CJ,=20 Reist CJ, Archer GE,=20 Zalutsky MR, Bigner DD (1998)=20 The class III variant of = the=20 epidermal growth factor receptor (EGFRvIII): characterization = and=20 utilization as an immunotherapeutic target. J Neurovirol 4:148=96158.
107.
Wong AJ, Ruppert JM, Bigner SH,=20 Grzeschik CH, Humphrey PA,=20 Bigner DS, Vogelstein B=20 (1992) Structural alterations of the = epidermal=20 growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA = 89:2965=962969.
108.
Wu AH, Xiao J, Anker L, Hall WA, Gregerson DS,=20 Cavenee WK=20 et al (2006) Identification of = EGFRvIII-derived CTL=20 epitopes restricted by HLA A0201 for dendritic cell based = immunotherapy=20 of gliomas. J=20 Neurooncol 76:23=9630.
109.
Zalutsky MR,=20 Moseley RP, Coakham HB,=20 Coleman RE, Bigner DD (1989)=20 Pharmacokinetics and = tumor=20 localization of 131I-labeled anti-tenascin monoclonal antibody = 81C6 in=20 patients with gliomas and other intracranial = malignancies. Cancer Res 49:2807=962813.

3D""=20

------=_NextPart_000_0000_01CA3DFA.2D78F2E0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www3.interscience.wiley.com/blank.html UNTITLED_PAGE= ------=_NextPart_000_0000_01CA3DFA.2D78F2E0--