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Subject: Tumors show enhanced dependency on glucose and glycolytic pathway Dwarakanath BS, Huilgol NG - J Can Res Ther
Date: Fri, 2 Apr 2010 18:39:35 +0200
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                <TD width=3D"100%" colSpan=3D3><FONT=20
                  class=3DtocAT><B>EDITORIAL</B></FONT></TD></TR>
              <TR>
                <TD width=3D"33%" height=3D5></TD>
                <TD width=3D"33%" height=3D5></TD>
                <TD width=3D"34%" height=3D5></TD></TR>
              <TR>
                <TD class=3Dother width=3D"100%" colSpan=3D3><B>Year =
</B>:=20
                  2009&nbsp; |&nbsp; <B>Volume</B> : 5&nbsp; |&nbsp;=20
                  <B>Issue</B> : 9&nbsp; |&nbsp; <B>Page</B> : =
1</TD></TR>
              <TR>
                <TD class=3Dother width=3D"100%"=20
            colSpan=3D3>&nbsp;</TD></TR></TBODY></TABLE>
            <P><FONT class=3DsTitle>Tumors show enhanced dependency on =
glucose and=20
            glycolytic pathway</FONT><BR><BR><FONT =
class=3DarticleAuthor>BS=20
            Dwarakanath<SUP>1</SUP>, Nagraj G=20
            Huilgol<SUP>2</SUP></FONT><BR><FONT=20
            class=3DAuthorAff><SUP>1</SUP>&nbsp;Institute of Nuclear =
Medicine and=20
            Allied Sciences, New Delhi, =
India<BR><SUP>2</SUP>&nbsp;Nanavati=20
            Hospital and MRC, Mumbai, India<BR></FONT><BR>
            <TABLE class=3DPrePublication width=3D"40%" border=3D0>
              <TBODY>
              <TR>
                <TD height=3D1>Date of Web Publication</TD>
                <TD>21-Aug-2009</TD></TR></TBODY></TABLE></P>
            <P><FONT class=3DCorrsAdd><B>Correspondence =
Address</B>:<BR>Nagraj G=20
            Huilgol<BR>Chief Radiation Oncologist, Dr. Balabhai Nanavati =

            Hospital, Mumbai-400 056 <BR>India<BR><A=20
            =
href=3D"http://www.cancerjournal.net/login.asp?rd=3Darticle.asp?issn=3D09=
73-1482;year=3D2009;volume=3D5;issue=3D9;spage=3D1;epage=3D1;aulast=3DDwa=
rakanath"><IMG=20
            alt=3D"Login to access the Email id"=20
            src=3D"http://www.medknow.com/images/email.gif" =
border=3D0></A>
            <P><B>Source of Support:</B> None, <B>Conflict of =
Interest:</B>=20
            None</P><B>DOI:</B>&nbsp;10.4103/0973-1482.55132<BR><BR><A=20
            =
href=3D"http://www.copyright.com/ccc/openurl.do?sid=3DMedknow&amp;issn=3D=
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            <TABLE class=3Dsitethis width=3D"100%" border=3D0>
              <TBODY>
              <TR>
                <TD class=3Dother><B>How to cite this=20
                  article:</B><BR>Dwarakanath BS, Huilgol NG. Tumors =
show=20
                  enhanced dependency on glucose and glycolytic pathway. =
J Can=20
                  Res Ther 2009;5:1</TD></TR></TBODY></TABLE><BR>
            <TABLE class=3Dsitethis width=3D"100%" border=3D0>
              <TBODY>
              <TR>
                <TD class=3Dother><B>How to cite this =
URL:</B><BR>Dwarakanath=20
                  BS, Huilgol NG. Tumors show enhanced dependency on =
glucose and=20
                  glycolytic pathway. J Can Res Ther [serial online] =
2009=20
                  [cited&nbsp;2010 Apr 2];5:1. Available from:&nbsp;<A=20
                  =
href=3D"http://www.cancerjournal.net/text.asp?2009/5/9/1/55132">http://ww=
w.cancerjournal.net/text.asp?2009/5/9/1/55132</A></TD></TR></TBODY></TABL=
E><BR><BR>Tumors=20
            show enhanced dependency on glucose and glycolytic pathway =
(even in=20
            the presence of oxygen) to generate metabolic energy (ATP) =
and=20
            macromolecular synthesis to sustain rapid cell =
proliferation. This=20
            phenomenon of altered metabolic state first described by the =
Nobel=20
            Laureate Otto Warburg almost 80 years ago is considered as a =

            hallmark of cancer, emerging concomitantly with malignant=20
            transformation, mitochondrial malfunction (linked to or =
independent=20
            of mutations), microregional hypoxia, and the evolution of =
aerobic=20
            glycolysis in most types of human tumors. While the enhanced =
glucose=20
            uptake is being increasingly exploited for the noninvasive =
detection=20
            and grading of tumors by positron emission tomography using =
the=20
            F-18-labeled glucose analog 2-deoxy-D-glucose (FDG), the =
development=20
            of therapeutic strategies based on this metabolic shift =
still=20
            remains a challenge. Recent studies to unravel the intricate =

            relationships between oncogenic transformation, enhanced =
glucose=20
            usage, degree of malignancy, and therapeutic resistance of =
tumors=20
            have rekindled interest to identify and develop new =
therapeutic=20
            strategies. <BR><BR>Although a number of pharmacological =
agents that=20
            target glucose transport and/or specific glycolytic enzymes=20
            overexpressed in tumors are currently under various stages =
of=20
            preclinical studies and clinical trials, the glucose analog, =

            2-deoxy-D-glucose (2-DG), has been most widely investigated =
in=20
            experimental and clinical oncology. While inhibitors of =
glycolysis=20
            have not been established as primary therapeutic agents in =
the=20
            treatment of cancer so far, there are compelling =
experimental as=20
            well as clinical evidences that have unequivocally =
established the=20
            potential of the glycolytic inhibitor, 2-deoxy-D-glucose, as =
an=20
            ideal adjuvant in enhancing the efficacy of radiotherapy and =

            chemotherapy of tumors. <BR><BR>The International Symposium =
on=20
            <I>Applications of 2-Deoxy-D-Glucose in the Management of =
Cancer</I>=20
            held in Delhi, India, during November, 2006, brought =
together many=20
            basic and clinical scientists across the world working in =
this=20
            important area of oncology. This issue of <I>Journal of =
Cancer=20
            Research and Therapeutics</I> briefly summarizes the current =
status=20
            of knowledge in this area through some updated manuscripts =
of=20
            selected presentations made during the symposium. It is =
clear that=20
            more research is required to elucidate further the =
mechanisms=20
            underlying the enhanced glucose metabolism in tumors and its =

            relationship with treatment resistance. However, what is =
more=20
            apparent is that the success of therapies using 2-DG seems =
to depend=20
            mainly on reducing toxicity to vital organs by optimal =
design of=20
            protocols using novel approaches. This will require a =
concerted=20
            effort of biomedical scientists and clinical oncologists =
working=20
            together closely with a common goal. <BR><BR>We thank all =
authors=20
            who have contributed to this issue and <I>Journal of Cancer =
Research=20
            and Therapeutics</I> for bringing out this special=20
issue.<BR><BR><BR>
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Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cancerjournal.net/templates/layer.js

var link=3Dnew Array()
var delay_hide=3D500
var menuobj;
var menu;
var default_menu_item=3D-1;

var bw=3Dnew lib_bwcheck();

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var  SITE_URL =3D "http://www.jpgmonline.com/";
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link[0]=3D'<table border=3D0 cellpadding=3D0 cellspacing=3D0 =
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link[0]+=3D'<td width=3D"15%" height=3D"20px" class=3D"topBand1Sel" =
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link[1]=3D'<table border=3D0 cellpadding=3D0 cellspacing=3D0 =
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link[1]+=3D'<td width=3D"19%" class=3D"topBand1Sel" =
height=3D"20px">&nbsp;&nbsp;<a class=3D"topmenu" href=3D'+SITE_URL =
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link[2]=3D'<table border=3D0 cellpadding=3D0 cellspacing=3D0 =
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link[2]+=3D'<td width=3D"57%" class=3D"topBand1Sel" =
height=3D"20px">&nbsp;&nbsp;<a class=3D"topmenu" href=3D'+SITE_URL =
+'search.asp>Simple Search</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a =
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href=3D'+SITE_URL +'imagesearch.asp>Image =
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href=3D'+SITE_URL +'backissues.asp>Year wise =
Issues</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a class=3D"topmenu" =
href=3D"backissuesxml.asp">Year wise Issues (XML)</a></td><td =
width=3D"20%" height=3D"20px"></td></tr></table>';

link[3]=3D'<table border=3D0 cellpadding=3D0 cellspacing=3D0 =
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link[3]+=3D'<td width=3D"16%" class=3D"topBand1Sel" =
height=3D"20px">&nbsp;&nbsp;<a  class=3D"topmenu" href=3D'+SITE_URL =
+'contributors.asp>Instructions</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a =
class=3D"topmenu" href=3D'+SITE_URL +'submitarticle.asp>Online =
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link[4]=3D'<table border=3D0 cellpadding=3D0 cellspacing=3D0 =
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link[4]+=3D'<td width=3D"19%" class=3D"topBand1Sel" =
height=3D"20px">&nbsp;&nbsp;<a class=3D"topmenu" href=3D'+SITE_URL =
+'refereeResource.asp>For Reviewers</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a =
class=3D"topmenu" href=3D'+SITE_URL +'contributors.asp>For =
Contributors</a></td><td width=3D"23%" =
height=3D"20px">&nbsp;</td></tr></table>';

link[5]=3D'<table border=3D0 cellpadding=3D0 cellspacing=3D0 =
class=3D"topBand2" width=3D"100%"><tr><td width=3D"55%" =
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link[5]+=3D'<td width=3D"24%" class=3D"topBand1Sel" =
height=3D"20px">&nbsp;&nbsp;<a class=3D"topmenu"  href=3D'+SITE_URL =
+'sections.asp?id=3D1;sid=3D>Images</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a  =
class=3D"topmenu" href=3D'+SITE_URL =
+'sections.asp?id=3D2;sid=3D>Reviews</a>&nbsp;&nbsp;|&nbsp;&nbsp;&nbsp;|&=
nbsp;&nbsp;<a class=3D"topmenu" href=3D'+SITE_URL =
+'sections.asp?id=3D4;sid=3D>Clinical Series</a></td><td =
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link[6]=3D'<table border=3D0 cellpadding=3D"0" cellspacing=3D"0" =
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+'searchmeeting.asp>Conferences</a>&nbsp;&nbsp;</td>';
link[6]+=3D'<td width=3D"10%">&nbsp;</td></tr></table>';

link[7]=3D'<table border=3D0 cellpadding=3D"0" cellspacing=3D"0" =
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link[7]+=3D'<td width=3D"35%" align=3D"right" class=3D"topBand1Sel" =
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+'addresses.asp>Addresses</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a =
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us</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a class=3D"topmenu" href=3D'+SITE_URL =
+'feedback.asp>Feedback</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a class=3D"topmenu" =
href=3D'+SITE_URL +'joinus.asp>Apply as Referee </a>&nbsp;&nbsp;</td>';
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function lib_bwcheck(){ //Browsercheck (needed)
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	this.agent=3Dnavigator.userAgent
	this.dom=3Ddocument.getElementById?1:0
	this.opera5=3Dthis.agent.indexOf("Opera 5")>-1
	this.ie5=3D(this.ver.indexOf("MSIE 5")>-1 && this.dom && =
!this.opera5)?1:0;=20
	this.ie6=3D(this.ver.indexOf("MSIE 6")>-1 && this.dom && =
!this.opera5)?1:0;
	this.ie4=3D(document.all && !this.dom && !this.opera5)?1:0;
	this.ie=3Dthis.ie4||this.ie5||this.ie6
	this.mac=3Dthis.agent.indexOf("Mac")>-1
	this.ns6=3D(this.dom && parseInt(this.ver) >=3D 5) ?1:0;=20
	this.ns4=3D(document.layers && !this.dom)?1:0;
	this.bw=3D(this.ie6 || this.ie5 || this.ie4 || this.ns4 || this.ns6 || =
this.opera5)
	return this;
}




function showHideLayer(obj,visible)
{							=09
	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	this.css.visibility =3D visible;
	this.css.top=3D'100px';
	this.css.left=3D'12px';
	if (bw.ie5 ||bw.ie4 || bw.ie6)
		this.css.width=3D'100%';=09
	else
		this.css.width=3D'98%';=09

	this.css.position=3D"absolute";

}


function writeSubmenu(obj,item)
{							=09
   	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	thecontent=3D(item=3D=3D-1)? "" : link[item]
	this.wref.innerHTML=3Dthecontent;

}


function navleftMouseOver(src)
{=20

	src.className=3D"leftnavcellover";
}=20



function navleftMouseOut(src)
{=20
	src.className=3D"";
}

function navtabMouseOver(src)
{=20
	src.className=3D"topBand1MO";
}=20



function navtabMouseOut(src)
{=20
	src.className=3D"topBand1";
}


function navMouseOver(src,item)
{=20
	if (item !=3D default_menu_item)
	src.className=3D"topBand1MO";=09

}=20



function navMouseOut(src,lyr)
{=20
	if (lyr!=3Ddefault_menu_item)
	src.className=3D"topBand1";=09
}

function onlpgld(item)
{
	default_menu_item=3Ditem;=09
	resetTDs(item);
	writeSubmenu("submenu",item);
	showHideLayer("submenu","visible");
}


function navMouseBotOut(src)
{
	src.className=3D"footer";
}


function navMouseBotOver(src)
{
	src.className=3D"pageSub";
}


function menu(src,item)
{=20

=09
	default_menu_item =3D item;
	writeSubmenu("submenu",item);
	showHideLayer("submenu","visible");=09
	resetTDs(item);

}=20

function resetTDs(item)
{
	var ob;
	for(x=3D0;x<8;x++)
	{
	obj=3D"m" + x;
 	ob=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	ob.className=3D"topBand1";
	if (x =3D=3D item)
		{
		ob.className=3D"topBand1Sel";
		}=09
	}
}


function writehDetail(obj,nm,cate,sing,dble,chkout,webadd)
	{			=09

   	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false;
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09

	var det;
	if (sing=3D=3D0){
		sing=3D"N.A";}
	else{
		sing=3D sing + " INR";}

	if (dble=3D=3D"0")
		dble =3D"N.A"
	else
		dble=3D dble+ " INR";

	if (webadd !=3D '')
	{
		=
det=3D'Hotel&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;:=
 <b>'+nm + '</b><br>Category&nbsp;&nbsp;&nbsp;&nbsp;:<b> '+ cate =
+'</b><br>Singlebed&nbsp;&nbsp;&nbsp;:<b> '+ sing =
+'</b><br>Doublebed&nbsp;&nbsp;:<b> '+ dble + =
'</b><br>Checkout&nbsp;&nbsp;&nbsp;&nbsp;: <b>' + chkout + =
'</b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a target=3D"_blank" =
href=3D"'+webadd+'">More Details >></a>';
	}
	else
	{
		=
det=3D'Hotel&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;:=
 <b>'+nm + '</b><br>Category&nbsp;&nbsp;&nbsp;&nbsp;:<b> '+ cate =
+'</b><br>Singlebed&nbsp;&nbsp;&nbsp;:<b> '+ sing =
+'</b><br>Doublebed&nbsp;&nbsp;:<b> '+ dble + =
'</b><br>Checkout&nbsp;&nbsp;&nbsp;&nbsp;: <b>' + chkout + '</b>';
	}=09

	this.wref.innerHTML=3Ddet;
}


function writetoObj(obj,curr, valu)
	{=09


   	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false;
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	this.wref.innerHTML=3D"<b>"+ curr+ valu + "</b>";
}
function openLogo(ClientID)
{
var attributes =3D 'toolbar=3D0,location=3D0,directories=3D0,status=3D0, =
menubar=3D0,scrollbars=3D1,resizable=3D1,width=3D550,height=3D600,left=3D=
0,top=3D0';
sealWin=3Dwindow.open('http://www.ccavenue.com/verifySeal.jsp?ClientID=3D=
'+ClientID ,'win',attributes);=20
self.name =3D 'mainWin';=20
}
function openWin(pg)
{

	if (pg.indexOf('special') >=3D 0 )
		{
		var attributes =3D =
'toolbar=3D0,location=3D0,directories=3D0,status=3D0, =
menubar=3D0,scrollbars=3D1,resizable=3D1,width=3D800,height=3D600,left=3D=
0,top=3D0';
		}
	else
		{
		var attributes =3D =
'toolbar=3D0,location=3D0,directories=3D0,status=3D0, =
menubar=3D0,scrollbars=3D1,resizable=3D1,width=3D600,height=3D400,left=3D=
0,top=3D0';
		}

	sealWin=3Dwindow.open(pg ,'',attributes);=20
	self.name =3D pg;=20
}

function chkgcform(frm)
{
	if (document.gc_form.gc_login.value=3D=3D'')
	{
		alert("Please enter your Gold Con username");
		return false;
	}
	if (document.gc_form.gc_pswd.value=3D=3D'')
	{
		alert("Please enter your Gold Con password");
		return false;
	}
	return true;
}
function writetCV(obj,cv,photo)
	{=09


   	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false;
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	this.wref.innerHTML=3D"<img src=3D'gc_images/" + photo + "'><br><br>" + =
cv;
}

function valfld(field)
{

	var valid =3D "0123456789"; // these are allowed values
	var ok =3D "yes";
	var temp;
	if (field.value.length =3D=3D 0 )
	{
		//alert("Invalid entry! please enter number");
		field.value =3D ""
		field.focus();
		field.select();
		return false;=09
	}
	for (var i=3D0; i<field.value.length; i++)
	{
		temp =3D "" + field.value.substring(i, i+1);
		if (valid.indexOf(temp) =3D=3D "-1")=20
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function getUACode()
{
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	j_dom=escape(document.domain);
	j_dom = j_dom.toLowerCase();
	j_dom= j_dom.replace(/www./,'');

	j_dom = 'www.'+j_dom;

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function getAdSenseCode()
{
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