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Subject: Current concepts in the pathology and genetics of gliomas Sarkar C, Jain A, Suri V - Indian J Cancer
Date: Sat, 9 May 2009 13:51:13 +0200
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Arial, Helvetica, sans-serif
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.PrePublication {
	BORDER-RIGHT: #eaead7 1px solid; BORDER-TOP: #eaead7 1px solid; =
FONT-SIZE: 11px; BORDER-LEFT: #eaead7 1px solid; COLOR: #464646; =
BORDER-BOTTOM: #eaead7 1px solid; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; BACKGROUND-COLOR: #e1e3ed
}
.sitethis {
	BORDER-RIGHT: #eaead1 1px solid; BORDER-TOP: #eaead1 1px solid; =
FONT-SIZE: 11px; BORDER-LEFT: #eaead1 1px solid; LINE-HEIGHT: 135%; =
BORDER-BOTTOM: #eaead1 1px solid; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; BACKGROUND-COLOR: #eaead7
}
.topBand1 {
	FONT-SIZE: 12px; COLOR: #ffffff; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; BACKGROUND-COLOR: #eaead7
}
.topBand11 {
	FONT-SIZE: 12px; FONT-FAMILY: Arial, Verdana, Helvetica, sans-serif; =
BACKGROUND-COLOR: #9bb4cb
}
.topBand1MO {
	FONT-SIZE: 12px; COLOR: #ffffff; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; BACKGROUND-COLOR: #c5c1bd
}
.topBand2MO {
	BORDER-RIGHT: #ffffff 1px solid; BORDER-TOP: #ffffff 1px solid; =
FONT-WEIGHT: bold; FONT-SIZE: 1px; BORDER-LEFT: #ffffff 1px solid; =
COLOR: #ffffff; BORDER-BOTTOM: #ffffff 1px solid; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif; BACKGROUND-COLOR: #9bb4cb
}
.buttonCell {
	BACKGROUND-COLOR: #eaead7
}
.leftnavover {
	BORDER-RIGHT: #ffffff 1px solid; BORDER-TOP: #ffffff 1px solid; =
FONT-WEIGHT: bold; FONT-SIZE: 8pt; BORDER-LEFT: #ffffff 1px solid; =
COLOR: #ffffff; BORDER-BOTTOM: #ffffff 1px solid; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif; BACKGROUND-COLOR: #fcf7e9
}
.sublinkFont {
	FONT-WEIGHT: bold; FONT-SIZE: 8pt; COLOR: #ffffff; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.topTable {
	FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; TEXT-DECORATION: none
}
.topBand2 {
	FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; BACKGROUND-COLOR: #757373; TEXT-DECORATION: none
}
.rightTopCorner {
	BORDER-RIGHT: #e1c876 1px solid; BORDER-TOP: #e1c876 1px solid; =
FONT-SIZE: 12px; BORDER-LEFT: #e1c876 1px solid; COLOR: #000000; =
BORDER-BOTTOM: #e1c876 1px solid; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; BACKGROUND-COLOR: #ffffff
}
.Highlight {
	FONT-WEIGHT: bold; FONT-SIZE: 12pt; COLOR: #194d78; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.HighlightArticleTitle {
	FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #ff6600; FONT-FAMILY: =
verdana ,Arial , Helvetica, sans-serif
}
.toctab {
	PADDING-RIGHT: 5px; BORDER-TOP: #eaead7 5px solid; PADDING-LEFT: 5px; =
FONT-SIZE: 9pt; BORDER-BOTTOM-COLOR: #ffffff; BORDER-LEFT: #f3f0ed 1px =
solid; LINE-HEIGHT: 135%; FONT-FAMILY: Verdana, Arial, Helvetica, =
sans-serif; BACKGROUND-COLOR: white; BORDER-RIGHT-COLOR: #ffffff
}
.tochead {
	BORDER-TOP: #cccccc 1px solid; FONT-WEIGHT: bold; FONT-SIZE: 14px; =
COLOR: #ac3232; BORDER-BOTTOM: #cccccc 1px solid; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.tocAT {
	FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #ac3232; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.line {
	BACKGROUND-COLOR: #eaead7
}
.HighlightVol {
	FONT-SIZE: 12px; COLOR: #194d78; FONT-FAMILY: Arial,Verdana,Helvetica, =
sans-serif
}
.HighlightAbstract {
	FONT-SIZE: 12px; COLOR: #222222; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif
}
.textBox {
	BORDER-RIGHT: #c0c0c0 1px solid; BORDER-TOP: #c0c0c0 1px solid; =
FONT-SIZE: 8pt; BORDER-LEFT: #c0c0c0 1px solid; BORDER-BOTTOM: #c0c0c0 =
1px solid; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif
}
.searchtable {
	BORDER-RIGHT: #e4e4de 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: =
#e4e4de 6px solid; PADDING-LEFT: 5px; FONT-SIZE: 10pt; BORDER-LEFT: =
#e4e4de 1px solid; LINE-HEIGHT: 125%; BORDER-BOTTOM: #e4e4de 1px solid; =
FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif
}
.articlepage {
	PADDING-RIGHT: 5px; BORDER-TOP: #eaead7 5px solid; PADDING-LEFT: 5px; =
FONT-SIZE: 9pt; BORDER-BOTTOM-COLOR: #ffffff; BORDER-LEFT: #f3f0ed 1px =
solid; LINE-HEIGHT: 135%; FONT-FAMILY: Verdana, Arial, Helvetica, =
sans-serif; BACKGROUND-COLOR: white; BORDER-RIGHT-COLOR: #ffffff
}
.parameter {
	FONT-SIZE: 12px; COLOR: #113452; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif
}
.parameterhead {
	FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #113452; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.parametertext {
	FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #113452; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.pageHead {
	FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #113452; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.other {
	FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #1f1f3f; FONT-FAMILY: =
Arial, Verdana, Helvetica, sans-serif
}
.sTitle {
	FONT-SIZE: 18px; COLOR: #ff6600; LINE-HEIGHT: 110%; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.ref {
	FONT-SIZE: 11px; COLOR: #cc6601; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif
}
.empty {
	PADDING-RIGHT: 2px; PADDING-LEFT: 2px; FONT-SIZE: 9pt; PADDING-TOP: =
2px; FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif; =
BACKGROUND-COLOR: white
}
.footer {
	COLOR: #ffffff; LINE-HEIGHT: 110%; BACKGROUND-COLOR: #d0dbe5
}
.menu {
	BORDER-RIGHT: #a1a1a1 10px solid; BORDER-TOP: #a1a1a1 10px solid; =
BORDER-LEFT: #a1a1a1 10px solid; BORDER-BOTTOM: #a1a1a1 10px solid
}
.sj {
	FONT-SIZE: 11px; BORDER-BOTTOM-COLOR: #f8c301; BORDER-LEFT: #757373 3px =
solid; COLOR: #333333; BORDER-TOP-COLOR: #f8c301; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif; BACKGROUND-COLOR: #eaead7; =
BORDER-RIGHT-COLOR: #f8c301
}
.menutable {
	BORDER-TOP: #dfd9da 1px solid; BACKGROUND-COLOR: #ffffff
}
.Footertab {
	FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana, Arial, =
Helvetica, sans-serif; BACKGROUND-COLOR: #d9e1e8
}
.foot {
	FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: Verdana,  Arial, =
Helvetica, sans-serif
}
.medknow {
	FONT-SIZE: 10px; COLOR: #444444; FONT-FAMILY: Verdana, Arial, =
Helvetica, sans-serif
}
.adlink {
	FONT-SIZE: 9px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, Helvetica, =
sans-serif
}
.hban {
	FONT-SIZE: 12px; COLOR: #000000; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif
}
.rtcm {
	BORDER-RIGHT: #ffffff 1px solid; FONT-WEIGHT: bold; FONT-SIZE: 11px; =
COLOR: #ffffff; BORDER-BOTTOM: #a2a2a1 2px solid; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif; BACKGROUND-COLOR: #eaead7
}
.w3c {
	FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #000000; FONT-FAMILY: Arial, =
Verdana, Helvetica, sans-serif
}
.vld {
	FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: =
Arial, Verdana, Helvetica, sans-serif
}
.ftl {
	CURSOR: hand
}
.bl {
	FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #000000; FONT-FAMILY: =
Arial, Verdana, Helvetica, sans-serif; BACKGROUND-COLOR: #ffffff
}
.spl {
	BORDER-RIGHT: #ffffff 3px dotted; BORDER-TOP: #ffffff 3px dotted; =
FONT-SIZE: 12px; MARGIN-LEFT: 2px; BORDER-LEFT: #ffffff 3px dotted; =
COLOR: #000000; MARGIN-RIGHT: 2px; BORDER-BOTTOM: #ffffff 3px dotted; =
FONT-STYLE: italic; FONT-FAMILY: Arial, verdana Helvetica, sans-serif; =
BACKGROUND-COLOR: #cdd8ba
}
.splnote {
	BORDER-RIGHT: #a6adc4 1px solid; BORDER-TOP: #a6adc4 1px solid; =
FONT-SIZE: 11px; BORDER-LEFT: #a6adc4 1px solid; LINE-HEIGHT: 135%; =
BORDER-BOTTOM: #a6adc4 1px solid; FONT-FAMILY: Arial, Verdana, =
Helvetica, sans-serif; BACKGROUND-COLOR: #e1f3ef
}
.jh {
	BACKGROUND-COLOR: #ffffff
}
.btm {
	BORDER-TOP: #eaead7 1px solid; BACKGROUND: =
url(http://www.indianjcancer.com/images/btm.gif) #eaead7 no-repeat right =
top; COLOR: #555555
}
.ft {
	BACKGROUND: url(http://www.indianjcancer.com/images/ft.gif)
}

------=_NextPart_000_0000_01C9D0AD.379E4A50
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.indianjcancer.com/templates/layer.js

var link=3Dnew Array()
var delay_hide=3D500
var menuobj;
var menu;
var default_menu_item;



function lib_bwcheck(){ //Browsercheck (needed)
	this.ver=3Dnavigator.appVersion
	this.agent=3Dnavigator.userAgent
	this.dom=3Ddocument.getElementById?1:0
	this.opera5=3Dthis.agent.indexOf("Opera 5")>-1
	this.ie5=3D(this.ver.indexOf("MSIE 5")>-1 && this.dom && =
!this.opera5)?1:0;=20
	this.ie6=3D(this.ver.indexOf("MSIE 6")>-1 && this.dom && =
!this.opera5)?1:0;
	this.ie4=3D(document.all && !this.dom && !this.opera5)?1:0;
	this.ie=3Dthis.ie4||this.ie5||this.ie6
	this.mac=3Dthis.agent.indexOf("Mac")>-1
	this.ns6=3D(this.dom && parseInt(this.ver) >=3D 5) ?1:0;=20
	this.ns4=3D(document.layers && !this.dom)?1:0;
	this.bw=3D(this.ie6 || this.ie5 || this.ie4 || this.ns4 || this.ns6 || =
this.opera5)
	return this
}
var bw=3Dnew lib_bwcheck();

function  x(obj,visible)
{	this.evnt=3Dbw.dom? 	=
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;

	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	this.css.visibility =3D visible;
	this.css.width=3D'100%';

}

function showHideLayer(obj,visible){							=09
   	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;

	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	this.css.visibility =3D visible;
	this.css.top=3D'94px';
	bw.ns4||bw.ns6?this.css.left=3D'-8px':
	this.css.left=3D'0px';
	this.css.width=3D'100%';
	this.css.position=3D"absolute";
}


function writeSubmenu(obj,item){							=09
   /*	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	thecontent=3D(item=3D=3D-1)? "" : link[item]
	this.wref.innerHTML=3Dthecontent;*/

}


function clearContent(obj){=09
					=09
   	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	thecontent=3D(item=3D=3D-1)? "" : link[item]
	this.wref.innerHTML=3D"";

}


function clear_delayhide()
{
	alert("asdASD");
	if (window.delayhide)
	{onlpgld(default_menu_item)
	clearTimeout(delayhide)
}
}

function contains_ns6(a, b)=20
{
	while (b.parentNode)
	if ((b =3D b.parentNode) =3D=3D a)
		return true;
	return false;
}



////


function navleftMouseOver(src)
{=20

	src.className=3D"leftnavcellover"
}=20



function navleftMouseOut(src)
{=20
	src.className=3D"leftnavcell"
}

function navtabMouseOver(src)
{=20

		src.className=3D"topBand1MO"
}=20



function navtabMouseOut(src)
{=20
	src.className=3D"topBand2"
}

////



function navMouseOver(src,item)
{=20

	src.className=3D"topBand1MO"
	//writeSubmenu("submenu",item);
	//showHideLayer("submenu","visible");=09
=09

}=20



function navMouseOut(src,lyr)
{=20
	src.className=3D"topBand1";
//	onlpgld(default_menu_item);
=09
}

function onload(item)
{
//	writeSubmenu("submenu",item);
//	showHideLayer("submenu","visible");
	=09
}

function onlpgld(item)
{
	default_menu_item=3Ditem;=09
	writeSubmenu("submenu",item);
	showHideLayer("submenu","visible");

	=09
}

function navMouseOversUB(src)
{=20
	src.className=3D"topBand2MO"

}=20
function navMouseOutsUB(src)
{=20
	src.className=3D"topBand2"
}
function navMouseBotOut(src)
{
	src.className=3D"leftnavcell"
}
function navMouseBotOver(src)
{
	src.className=3D"leftnavcellover"
}

function loadMenu(index)
{
	writeMenu("menu",item);
	showHideLayer("menu","visible");=09
	if (index >=3D 0)
	{
		onload(index)	=09
	}
}


function showMenu(e,f)
{
	var ie4=3Ddocument.all&&navigator.userAgent.indexOf("Opera")=3D=3D-1
	var ns6=3Ddocument.getElementById&&!document.all
	var ns4=3Ddocument.layers
	eventX=3Die4? event.clientX : ns6? e.clientX : e.x
	eventY=3Die4? event.clientY : ns6? e.clientY : e.y
	var rightedge=3Die4? document.body.clientWidth-eventX : =
window.innerWidth-eventX
	var bottomedge=3Die4? document.body.clientHeight-eventY : =
window.innerHeight-eventY

	var obj=3D"floatmenu";
	this.evnt=3Dbw.dom? 	=
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	this.css.visibility =3D "visible";
	this.css.left=3Die4? document.body.scrollLeft+eventX : ns6? =
window.pageXOffset+eventX : eventX
	 if (bottomedge<this.css.contentheight)
		this.css.top=3Die4? =
document.body.scrollTop+eventY-this.css.contentheight : ns6? =
window.pageYOffset+eventY-this.css.contentheight : =
eventY-this.css.contentheight;
	 else
		 this.css.top=3Die4? document.body.scrollTop+event.clientY : ns6? =
window.pageYOffset+eventY : eventY=20

	this.css.visibility=3D"visible";
	this.css.top=3DeventX;

	alert(eventX);

}


function writeMenu(obj,item)
{
  	this.evnt=3Dbw.dom? =
document.getElementById(obj):bw.ie4?document.all[obj]:bw.ns4?document.lay=
ers[obj]:0;
	if(!this.evnt) return false
	this.css=3Dbw.dom||bw.ie4?this.evnt.style:bw.ns4?this.evnt:0;=09
   	this.wref=3Dbw.dom||bw.ie4?this.evnt:bw.ns4?this.css.document:0;=09
	thecontent=3D(item=3D=3D-1)? "" : menu;
	this.wref.innerHTML=3Dthecontent;

}

function setCSS(typ)
{=20
	var i, a, main;
  for(i=3D0; (a =3D document.getElementsByTagName("link")[i]); i++)=20
	{

	    if(a.getAttribute("rel").indexOf("style") !=3D -1 && 	=
a.getAttribute("title")) {
      	    a.disabled =3D true;
            if(a.getAttribute("title") =3D=3D typ) a.disabled =3D false;
    }
  }
=09
}



function getActiveStyleSheet() {
  var i, a;
  for(i=3D0; (a =3D document.getElementsByTagName("link")[i]); i++) {
    if(a.getAttribute("rel").indexOf("style") !=3D -1 && =
a.getAttribute("title") && !a.disabled) return a.getAttribute("title");
  }
  return null;
}
function openWin(pg)
{

if (pg.indexOf('special') >=3D 0 || pg.indexOf('changeaddress') >=3D 0 )
{
var attributes =3D 'toolbar=3D0,location=3D0,directories=3D0,status=3D0, =
menubar=3D0,scrollbars=3DYes,resizable=3D1,width=3D800,height=3D600,left=3D=
0,top=3D0';
}
else
{
var attributes =3D 'toolbar=3D0,location=3D0,directories=3D0,status=3D0, =
menubar=3D0,scrollbars=3D1,resizable=3D1,width=3D600,height=3D400,left=3D=
0,top=3D0';
}

sealWin=3Dwindow.open(pg ,'',attributes);=20
self.name =3D pg;=20
}
function valfld(field)
{

	var valid =3D "0123456789"; // these are allowed values
	var ok =3D "yes";
	var temp;
	if (field.value.length =3D=3D 0 )
	{
		//alert("Invalid entry! please enter number");
		field.value =3D ""
		field.focus();
		field.select();
		return false;=09
	}
	for (var i=3D0; i<field.value.length; i++)
	{
		temp =3D "" + field.value.substring(i, i+1);
		if (valid.indexOf(temp) =3D=3D "-1")=20
		ok =3D "no";
	}
	if (ok =3D=3D "no")=20
	{
		alert("Invalid entry! Only numbers are allowed!");
		field.value =3D ""
		field.focus();
		field.select();

		return false;
	}
	else
		return true;
	}


function chkvldemail(email_address)
   {
         //Assumes that valid email addresses consist of =
user_name@domain.tld
         at =3D email_address.indexOf('@');
         dot =3D email_address.indexOf('.');
        =20
         if(at =3D=3D -1 ||=20
            dot =3D=3D -1 ||        =20
            dot =3D=3D 0 )
		{=09
			alert("Please enter valid email address 1.");
            return(false);
		}
           =20
         user_name =3D email_address.substr(0, at);
         domain_name =3D email_address.substr(at + 1, =
email_address.length);                 =20

         if(Validate_String(user_name) =3D=3D=3D false || =
Validate_String(domain_name) =3D=3D=3D false)
		{=09
			alert("Please enter valid email address.");
	            return(false);=20
                }
         else
		 return(true);
}

function Validate_String(string, return_invalid_chars)
         {
         valid_chars =3D =
'1234567890-_.^~abcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZ';
         invalid_chars =3D '';
        =20
         if(string =3D=3D null || string =3D=3D '')
            return(true);
        =20
         //For every character on the string.  =20
         for(index =3D 0; index < string.length; index++)
            {
            charx =3D string.substr(index, 1);                       =20
           =20
            //Is it a valid character?
            if(valid_chars.indexOf(charx) =3D=3D -1)
              {
              //If not, is it already on the list of invalid characters?
              if(invalid_chars.indexOf(charx) =3D=3D -1)
                {
                //If it's not, add it.
                if(invalid_chars =3D=3D '')
                   invalid_chars +=3D charx;
                else
                   invalid_chars +=3D ', ' + charx;
                }
              }
            }                    =20
           =20
         //If the string does not contain invalid characters, the =
function will return true.
         //If it does, it will either return false or a list of the =
invalid characters used
         //in the string, depending on the value of the second =
parameter.
         if(return_invalid_chars =3D=3D true && invalid_chars !=3D '')
           {
           last_comma =3D invalid_chars.lastIndexOf(',');
          =20
           if(last_comma !=3D -1)
              invalid_chars =3D invalid_chars.substr(0, $last_comma) +=20
              ' and ' + invalid_chars.substr(last_comma + 1, =
invalid_chars.length);
                     =20
           return(invalid_chars);
           }
         else
           return(invalid_chars =3D=3D '');=20
         }

function trimstr(par)
{

while (par.charAt(0)=3D=3D" "){
par=3Dpar.replace(" ","")
}
i=3Dpar.length-1
while(par.charAt(i)=3D=3D" "){
par=3Dpar.slice(0,i)
i=3Di-1
}
return par
}

// var xyz =3D createBar(
// total_width,
// total_height,
// background_color,
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<META=20
content=3D"Glioma, oligodendroglioma, astrocytoma, glioblastoma, 1p/19q =
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<META=20
content=3D"In recent years, there has been a marked improvement in our =
understanding of molecular genetics of gliomas. These advancements offer =
hope for development of tailored therapies targeting a tumor's unique =
molecular profile, and may also translate into improved classification =
and identification of newer prognostic markers. This review focuses on =
the neuropathological features of different types of glial neoplasms =
according to the World Health Organization classification, and the =
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mechanisms underlying tumor progression, diagnostic and prognostic =
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                <TD width=3D"100%" colSpan=3D3><FONT=20
                  class=3DtocAT><B>SYMPOSIUM</B></FONT></TD></TR>
              <TR>
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                <TD width=3D"34%" height=3D5></TD></TR>
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                <TD class=3Dother width=3D"100%" colSpan=3D3><B>Year =
</B>:=20
                  2009&nbsp; |&nbsp; <B>Volume</B> : 46&nbsp; |&nbsp;=20
                  <B>Issue</B> : 2&nbsp; |&nbsp; <B>Page</B> : =
108-119</TD></TR>
              <TR>
                <TD class=3Dother width=3D"100%"=20
            colSpan=3D3>&nbsp;</TD></TR></TBODY></TABLE>
            <P><FONT class=3DsTitle>Current concepts in the pathology =
and genetics=20
            of gliomas</FONT><BR><BR><FONT class=3DarticleAuthor>C =
Sarkar, A Jain,=20
            V Suri</FONT><BR><FONT class=3DAuthorAff>&nbsp;Department of =

            Pathology, All India Institute of Medical Sciences, New =
Delhi,=20
            India<BR></FONT><BR></P>
            <P><FONT class=3DCorrsAdd><B>Correspondence =
Address</B>:<BR>C=20
            Sarkar<BR>Department of Pathology, All India Institute of =
Medical=20
            Sciences, New Delhi <BR>India<BR><A=20
            =
href=3D"http://www.indianjcancer.com/login.asp?rd=3Darticle.asp?issn=3D00=
19-509X;year=3D2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3D=
Sarkar"><IMG=20
            alt=3D"Login to access the Email id"=20
            src=3D"http://www.medknow.com/images/email.gif" =
border=3D0></A>
            <P><B>Source of Support:</B> None, <B>Conflict of =
Interest:</B>=20
            None</P><B>DOI</B>:&nbsp;10.4103/0019-509X.49148<BR></FONT>
            <P></P>
            <TABLE cellSpacing=3D0 cellPadding=3D0 width=3D"100%" =
border=3D0>
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            border=3D0>
              <TBODY>
              <TR>
                <TD class=3DpageSub width=3D"85%" =
height=3D15>&nbsp;=BB<A=20
                  name=3Dabstract></A>&nbsp;Abstract</TD>
                <TD class=3Dinthis align=3Dright>&nbsp;</TD>
                <TD width=3D"15%" height=3D15></TD></TR></TBODY></TABLE>
            <P class=3Dabst>In recent years, there has been a marked =
improvement=20
            in our understanding of molecular genetics of gliomas. These =

            advancements offer hope for development of tailored =
therapies=20
            targeting a tumor's unique molecular profile, and may also =
translate=20
            into improved classification and identification of newer =
prognostic=20
            markers. This review focuses on the neuropathological =
features of=20
            different types of glial neoplasms according to the World =
Health=20
            Organization classification, and the recent advances in =
their=20
            molecular biology with emphasis on the genetic mechanisms =
underlying=20
            tumor progression, diagnostic and prognostic markers and =
potential=20
            therapeutic targets.</P><BR>
            <P class=3Dkyds><B>Keywords:</B>&nbsp;Glioma, =
oligodendroglioma,=20
            astrocytoma, glioblastoma, 1p/19q deletion</P><BR>
            <TABLE class=3Dsitethis width=3D"100%" border=3D0>
              <TBODY>
              <TR>
                <TD class=3Dother><B>How to cite this =
article:</B><BR>Sarkar C,=20
                  Jain A, Suri V. Current concepts in the pathology and =
genetics=20
                  of gliomas. Indian J Cancer=20
            2009;46:108-19</TD></TR></TBODY></TABLE><BR>
            <TABLE class=3Dsitethis width=3D"100%" border=3D0>
              <TBODY>
              <TR>
                <TD class=3Dother><B>How to cite this URL:</B><BR>Sarkar =
C, Jain=20
                  A, Suri V. Current concepts in the pathology and =
genetics of=20
                  gliomas. Indian J Cancer [serial online] 2009 =
[cited&nbsp;2009=20
                  May 9];46:108-19. Available from:&nbsp;<A=20
                  =
href=3D"http://www.indianjcancer.com/text.asp?2009/46/2/108/49148">http:/=
/www.indianjcancer.com/text.asp?2009/46/2/108/49148</A></TD></TR></TBODY>=
</TABLE><BR><BR><BR>
            <TABLE class=3DleftNav cellSpacing=3D0 cellPadding=3D0 =
width=3D"100%"=20
            border=3D0>
              <TBODY>
              <TR>
                <TD class=3DpageSub><A=20
                  =
name=3DIntroduction></A>&nbsp;=BB&nbsp;Introduction</TD>
                <TD class=3Dinthis align=3Dright>&nbsp;</TD>
                <TD align=3Dright width=3D"15%"><A=20
                  =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#top"><=
IMG=20
                  alt=3DTop=20
                  =
src=3D"http://www.indianjcancer.com/images/arrow_top.gif"=20
                  =
border=3D0></A></TD></TR></TBODY></TABLE><BR><BR>Gliomas are the most=20
            common primary brain tumors of adults. Gliomas are =
classified by the=20
            World Health Organization (WHO), according to their =
morphological=20
            characteristics, into astrocytic, oligodendroglial, and =
mixed=20
            tumors.<B> </B>The first WHO classification of tumors of the =
nervous=20
            system was published in 1979,<SUP> <A class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref1" =

            name=3Dft1>[1]</A></SUP> followed by revisions in 1993,<SUP> =
<A=20
            class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref2" =

            name=3Dft2>[2]</A></SUP> 2000,<SUP> <A class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref3" =

            name=3Dft3>[3]</A></SUP> and 2007.<SUP> <A class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref4" =

            name=3Dft4>[4]</A></SUP> The present WHO classification is =
considered=20
            the gold standard for prognostication. <A class=3Dref=20
            =
onmouseover=3D"omovimg('viewimaget.asp?img=3DIndianJournalofCancer_2009_4=
6_2_108_49148_b1.jpg')"=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#">[Tab=
le=20
            1]</A> gives the classification of glial tumors with their=20
            incidence, age, and sex distribution. <BR><BR>It is unclear =
whether=20
            these tumors result from the transformation of an immature =
precursor=20
            or from the dedifferentiation of a mature glial cell.<SUP> =
<A=20
            class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref5" =

            name=3Dft5>[5]</A></SUP> A number of prognostic and =
predictive factors=20
            are proposed for estimating the behavior of gliomas, =
including,=20
            clinical parameters, histological grading, proliferation =
indices,=20
            and molecular markers. Over the past 20 years, a number of=20
            chromosomal, genetic, and epigenetic alterations have been =
found to=20
            be associated with different histological types and =
malignancy=20
            grades of gliomas. <BR><BR>Genotype/phenotype correlation =
studies=20
            have identified early and late genetic alterations related =
either to=20
            astrocytic or oligodendroglial phenotype. They complement =
the=20
            existing WHO morphological classification and provide =
additional=20
            prognostic markers such as 1p/19q deletion in =
oligodendrogliomas.=20
            <BR><BR><BR>
            <TABLE class=3DleftNav cellSpacing=3D0 cellPadding=3D0 =
width=3D"100%"=20
            border=3D0>
              <TBODY>
              <TR>
                <TD class=3DpageSub><A=20
                  name=3D"Neuropathology of astrocytic =
tumors"></A>&nbsp;=BB&nbsp;Neuropathology=20
                  of astrocytic tumors</TD>
                <TD class=3Dinthis align=3Dright>&nbsp;</TD>
                <TD align=3Dright width=3D"15%"><A=20
                  =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#top"><=
IMG=20
                  alt=3DTop=20
                  =
src=3D"http://www.indianjcancer.com/images/arrow_top.gif"=20
                  =
border=3D0></A></TD></TR></TBODY></TABLE><BR><BR><B>Pilocytic=20
            astrocytoma (WHO grade I)</B><BR><BR>Pilocytic astrocytomas =
are=20
            relatively circumscribed, slow growing, often cystic =
neoplasms,=20
            occurring in children and young adults, most commonly =
affecting the=20
            cerebellum followed by optic nerve and optic chiasma, =
hypothalamus,=20
            thalamus, basal ganglia, and brainstem.<SUP> <A class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref4" =

            name=3Dft4>[4]</A>,<A class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref6" =

            name=3Dft6>[6]</A></SUP> Histologically they are =
characterized by a=20
            biphasic pattern consisting of piloid areas with bipolar =
cells=20
            associated with Rosenthal fibers, and protoplasmic areas =
comprising=20
            of loosely textured multipolar cells with microcysts and=20
            eosinophilic granular bodies. Sometimes glomeruloid vascular =

            proliferation may be observed, but it is not a sign of =
malignancy.=20
            These cells are strongly glial fibrillary acidic protein =
(GFAP)=20
            immunopositive. Proliferation indices are low with the MIB-1 =

            labeling index (MIB-1 LI) ranging from 0-3.9% (mean =
1.1%),<SUP> <A=20
            class=3Dref=20
            =
href=3D"http://www.indianjcancer.com/article.asp?issn=3D0019-509X;year=3D=
2009;volume=3D46;issue=3D2;spage=3D108;epage=3D119;aulast=3DSarkar#ref7" =

            name=3Dft7>[7]</A></SUP> however, due to overlap of this =
range with=20
            diffuse astrocytomas grade II (mean 2.3%), it is of little =
use in=20
            diagnosis.<BR><BR><I>Genetics</I> : Relatively little is =
known about=20
            chromosomal and genetic a