From: Subject: Therapeutic Difficulty in a Case of Supratentorial Primitive Neuroectodermal Tumor Diagnosed during Pregnancy Date: Tue, 3 Mar 2009 19:14:49 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C99C34.5260FC50" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2640822 =EF=BB=BF Therapeutic Difficulty in a Case of Supratentorial = Primitive Neuroectodermal Tumor Diagnosed during Pregnancy = <= LINK=20 rel=3Dstylesheet type=3Dtext/css=20 href=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbars-slatebl= ue.css"><= LINK=20 rel=3Dstylesheet type=3Dtext/css=20 href=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcrefs5.css"> =
3D"Journal3DJournal3D"On-line
Journal=20 List > J=20 Korean Neurosurg Soc > v.4= 5(1);=20 Jan 2009
Abstract
"=20 = src=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif">= Full=20 Text
PDF=20 (306K)
Con= tents
Archive

PubMed articles by:
Sarica,=20 F.
Tufan,=20 K.
Sen,=20 O.
Erdogan,=20 B.
J Korean Neurosurg = Soc.=20 2009 January; = 45(1): 39=E2=80=9342.=20
Published online 2009 = January 31.=20 doi:=20 10.3340/jkns.2009.45.1.39.
PMCID:=20 PMC2640822
Copyright<= /A>=20 =C2=A9 2009 The Korean Neurosurgical Society
Therapeutic Difficulty in a Case of = Supratentorial=20 Primitive Neuroectodermal Tumor Diagnosed during Pregnancy
Feyzi Birol Sarica, = M.D.,=20 Kadir Tufan, M.D.,3D"corresponding=20 Orhan Sen, M.D., and Bulent Erdogan, M.D.
Department of Neurosurgery, Baskent = University Faculty=20 of Medicine, Ankara, Turkey.
3D"correspondingCorresponding=20 author.
Address for reprints: Kadir Tufan, M.D. = Department=20 of Neurosurgery, Baskent University Baskent Universitesi Adana = Uygulama ve=20 Arastirma Hastanesi, Dadaloglu Mahallesi. 39. Sokak No: 6, 01250, = Adana -=20 TURKEY. Tel: +90-322-3272727, Fax: +90-322-3271273, Email: kadirtufan/at/hotmail.com
Received June 3, 2008; Accepted December = 29,=20 2008.
"=20 = src=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif">= Abstract
Abstract
We report a supratentorial primitive = neuroectodermal tumor (sPNET) in 17-year-old primipara in the = second=20 trimester her pregnancy. Magnetic resonance imaging revealed a = left=20 frontoparietal mass with solid and cystic component. Gross-total = resection=20 was achieved via a left frontoparietal craniotomy. It was decided = to=20 suspend the radiotherapy and chemotherapy until the 30 weeks of = gestation.=20 But, a sudden uncal herniation was developed due to the = reccurrence of the=20 tumor and bleeding into the tumor at the 25 weeks of gestation and = the=20 patient died after urgent decompressive surgery. sPNETs is an = extremely=20 rare brain tumor in pregnancy and only two cases were reported in = the=20 literature to date. There is no universally agreed treatment = protocol for=20 sPNETs during pregnancy and a multidisciplinary approach is = required in=20 treatment. In the present study, the clinical, histopathological = features=20 and therapeutical difficulties of sPNETs diagnosed during = pregnancy was=20 discussed with the literature review.
Keywords: Multidisciplinary treatment, Pregnancy, = Supratentorial=20 primitive neuroectodermal tumor
"=20 = src=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif">= INTRODUCTION
INTRODUCTION
Primitive neuroectodermal tumors (PNETs) = are poorly=20 differentiated neoplasms with quite aggressive progression, = originating in=20 the germinal matrix cells of the primitive neural tube in the = central=20 nervous system. PNETs comprise 1% of all childhood primary central = nervous=20 system (CNS) tumors and 5% of tumors with supratentorial location. = These=20 usually occur in children before the age of one and follow a = rather=20 aggressive course3,5).=20 Due to rapid growth potential, they present with symptoms related = to=20 increased intracranial pressure (ICP). According to the World = Health=20 Organization (WHO) classification of 1993, PNETs localized in the=20 cerebellum were classified as PNET/Medulloblastoma, while those = with=20 non-cerebellar localization were classified as supratentorial = primitive=20 neuroectodermal tumors (sPNETs). In the 2000 WHO histological=20 classification of tumors of CNS, the terms Neuroblastoma and=20 Ganglioneuroblastoma appear under the sPNETs heading.
In addition to being rarely seen in = adults, sPNETs=20 are extremely rare during pregnancy. Only 2 such cases have been=20 previously reported1,11).=20 Treatment of sPNETs in pregnancy is complicated by the presence of = the=20 fetus. In the present study, the clinical, histopathological = features and=20 therapeutical difficulties of sPNETs during pregnancy are = discussed with=20 the literature review.
"=20 = src=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif">= CASE=20 REPORT
CASE REPORT
A 17-year-old woman, gravida 1 para 0, in = her 20th=20 week of pregnancy, was admitted to hospital with headache and = weakness in=20 the right arm and leg. Confusion, dysphasia and right hemiparesis = (grade=20 1/5) were detected in neurological examination. Magnetic resonance = imaging=20 revealed, a left frontoparietal cystic mass (size : = 5.5=C3=974.5=C3=972.5 cm) with=20 peripheral enhancement (Fig.=20 1). Gross-total resection was achieved via a left = frontoparietal=20 craniotomy (Fig.=20 2). Atypical cells, with a round hyperchromatic nucleus and = narrow=20 cytoplasm, few rosette-like structures occasionally displaying a = diffuse=20 pattern were seen on Hematoxylin & Eosin-stained sections (Fig.=20 3A). It was considered as a small cell malignant tumor. = Postoperative=20 course was uneventful and moderate improvement in her right = hemiparesis=20 (grade 4/5) and dysphasia were noted. Consultation with the = Medical=20 Oncology, Radiation Oncology and Gynecology Departments resulted = in=20 decision to give an adjuvant radiation therapy to the neurocranium = and=20 chemotherapy at 30 weeks of gestation and to deliver the baby at = 34=20 weeks.
Fig.=20 1
A cystic = mass=20 (size: 5.5=C3=974.5=C3=972.5 cm) lying from inferior gyrus = of the left frontal=20 lobe to the temporal lobe causing 1.5 cm subfalcine = herniation,=20 revealing slight contrast and accompanied by a solid = component on=20 the posteolateral is observed=20 (more ...)
Fig.=20 2
Postoperative=20 cerebral magnetic resonance image shows the removal of the = tumor via=20 left frontoparietotemporal craniotomy, postoperative changes = and=20 decrease of subfalcine herniation towards the=20 right.
Fig.=20 3
A : The = arrangement=20 of the tumor cells with pleomorphic and hyperchromatic = nucleus in=20 perivascular rosette formation (HE=C3=97400). B : The = positivity of=20 Synaptophysin in the cytoplasm of tumor cells=20 (=C3=97400).
Light microscopic examination depicted malignant = neoplastic=20 development with the features explained above. Frequent mitosis = was=20 noticed (Fig.=20 3A). Glial Fibrillary Acidic Protein (GFAP), CD-99, Neuron = Specific=20 Enolase (NSE), Chromogranin, Synaptophysin focal positive (Fig.=20 3B), Leukocyte Common Antibody (LCA) and Desmin negative cells = were=20 observed by immunohistochemical staining techniques. It was = reported as a=20 primitive neuroectodermal tumor when evaluated together with the = present=20 morphological and immunohistochemical findings.
At 25 weeks of pregnancy, patient was=20 re-hospitalized by the Gynecology Department due to threatened = abortion=20 and headache. On day 3 of hospitalization, patient developed a = sudden=20 nausea and vomiting and lost her consciousness gradually. On the=20 neurological examination, dilated right pupil, decorticated = rigidity by=20 painful stimuli and Cheyne-Stokes respiration were detected. = Glasgow coma=20 scale score was 5/15. After safeguarding the abdomen, cranial CT = showed=20 recurrence of the both cystic and solid component of the tumor = measuring=20 5.5=C3=974.5 cm and acute hemorrhage in the tumor with brain shift = toward to=20 right side. (Fig.=20 4). After mannitol and steroid infusion, the patient was = urgently=20 taken to the operation room together with the obstetricians. The = cystic=20 mass was aspirated and the craniotomy flap was removed for = decompression=20 (Fig.=20 5). Simultaneously, obstetricians delivered, by caesarian = section, a=20 1,770 g girl with an Apgar score of 7/9. However, no improvement = was=20 observed on the patient's postoperative neurological status = possibly due=20 to uncal herniation, and she died on postoperative day 4.
Fig.=20 4
Cranial = computed=20 tomography before the second operation reveals the = recurrence of=20 both cystic and solid component of the tumor and acute = hemorrhage in=20 the = tumor.
Fig.=20 5
Control = computed=20 tomography after the second operation shows the craniectomy = site.=20 Images verified the adequate decompression of the cystic and = hemorrhagic = mass.
"=20 = src=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif">= DISCUSSION
DISCUSSION
The relationship between brain tumor and = pregnancy=20 are not well known and no detailed studies that explain = pathophysiological=20 behavior of brain tumors during pregnancy are available. Numerous=20 aggravating factors were associated with brain tumors during = pregnancy.=20 Some of these factors include expansion of the tumor vascular bed = in=20 conjunction with the maternal blood changes, vascular engorgement, = angioformative characteristic of the stromal cell and endocrine = changes.=20 Potential reasons for a decreased incidence of brain tumors during = pregnancy may include the antiangiogenic hormonal milieu induced = by=20 progesterone or other growth factors that regulate the maternal = response=20 to the growing fetus2,7,9).=20 However, when reviewing the literature, no reliable causative = factor was=20 found for the development and / or aggravation of a brain tumor = during=20 pregnancy.
The clinical behavior of malignant brain tumors = involves=20 general non-specific and non-characteristic findings in pregnacy. = For=20 instance, nausea and vomiting, common in early pregnancy, are also = present=20 in about 25% of pregnant women with an intracranial neoplasm. = Persistent=20 nausea and emesis have been mistakenly attributed to hyperemesis=20 gravidarum in cases of a brain tumor7,9).=20 Headache may occur in pregnancy, but the new onset of a persistent = headache, particularly associated with nausea, vomiting, or focal=20 neurological signs, mandates neuroimaging. The symptoms are = similar to=20 other malignant supratentorial tumors and occur as a result of = direct=20 effect the tumor and increased intracranial pressure. Focal = neurological=20 findings develop due to mass effect. The initial duration of the = symptoms,=20 which was reported to reach a peak between 1 and 3 months though = it=20 displays a variation between 1 and 12 months, was only 10 days in = our=20 patient5,8,9).
First case of sPNETs during pregnancy was reported = by=20 Bodner-Adler and colleagues in 2006 in Austria. The tumor was = detected in=20 a 26-year-old patient who was 20 weeks pregnant. Patient underwent = gross-total resection of the tumor, followed by neoadjuvant = radiation=20 therapy to the neurocranium and chemotherapy with Temozolomide at = 30 weeks=20 of gestation. The baby was delivered at 34 weeks of gestation by = Caesarian=20 section and then the patient received a complete radiation therapy = to the=20 craniospinal axis. Patient was admitted to the hospital for = follow-up 3=20 months after diagnosis. No evidence of disease was detected1).=20 However, the tolerability of the doses of chemotherapy and RT was = not=20 discussed during the postoperative observation of the baby. The = second=20 case was reported in Italy in 2007 by Ulivieri et al. Tumor was = diagnosed=20 at 20 weeks of gestation in an 18-year old patient who underwent = total=20 resection. When tumor recurrence was detected 3 months later, baby = was=20 delivered by Caesarian section, patient was re-operated and the = tumor was=20 excised, followed by combined chemotherapy and radiotherapy11).=20 It is not possible to comment on mean survival since both cases = were=20 detected very recently. Histopathological and radiological = features and=20 clinical course of sPNETs diagnosed during pregnancy are similar = to sPNETs=20 in normal adults. In this report, we, by taking pregnancy into = account,=20 considered the effects of therapeutic options on the fetus and = used the=20 data gathered from adult sPNET cases as well in outlining the = treatment=20 plan following the delivery of the baby.
Treatment of sPNETs in pregnancy is complicated by = the=20 presence of the fetus. These lesions require diagnostic = intervention and=20 treatment regardless of the gestational age of the fetus. The = patient and=20 her family should be clearly but compassionately informed of the = poor=20 prognosis of these lesions to allow her to guide the medical team = about=20 her priorities for treatment. The first choice in the treatment is = radical=20 surgical resection. The basic approach in surgery should be, as in = other=20 intrinsic neoplasms, the radical removal of the tumor using = internal=20 decompression in a manner to give the least damage to the = surrounding=20 healthy parenchyma and vascular structures1,3,5,6).=20 Kim et al. reported the type of resection being the major = prognostic=20 factor5).
Gestational month is another very important = parameter in=20 pregnant patients with radiosensitive malignant brain tumors. = Radiotherapy=20 during pregnancy might cause harm to the developing fetus. = Generally,=20 pregnant women with malignant diseases are advised to delay = radiotherapy=20 until after delivery. However, this advice is not based on = knowledge of=20 the risks of radiation to the unborn child. In general, the = expected=20 radiation effects, such as mental retardation and organ = malformations=20 probably arise above a threshold dose of 0.1-0.2 Gy. This dose = threshold=20 is generally not enough for curative radiotherapy during = pregnancy4).
Publications regarding the administration of = chemotherapy=20 postoperatively are few in number and the results are = contradictory for=20 sPNETs3,8,10).=20 Information related to pregnancy and cytotoxic treatments are = generally=20 derived from animal studies. Those obtained from human studies are = limited=20 to case reports or small series. The most critical period with = regard to=20 genetic and teratogenic effects of chemotherapeutic agents on = fetus is the=20 active organogenesis stage that takes place between 3-10 weeks of=20 gestation. The frequency of teratogenity during this period was = reported=20 between 10-20%. Therefore, chemotherapeutic agents should be = avoided as=20 much as possible in the first trimester. It is accepted that = chemotherapy=20 does not further increase the risk of fetal malformations even in = the 2nd=20 trimester. Dysfunction of the endocrine system and motor-mental=20 retardation are amongst the late effects that are related to=20 chemotherapeutics and we do not have sufficient knowledge on = them7,9).
sPNETs in adults and children are similar = with=20 regard to the clinical features and prognosis. Type of resection = is the=20 major prognostic factor. Presence of systematic metastasis such as = leptomeningeal metastasis and involvement of the lungs and the = lymph nodes=20 are poor prognostic factors. Prognosis of sPNETs is generally = poor. Mean=20 survival is 24 months in adults although 5-year survival was also = reported=20 in a few patients3,5,6,8).
"=20 = src=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif">= CONCLUSION
CONCLUSION
sPNETs are rarely seen during = pregnancy and=20 only two cases were reported in the literature to date. The = primary choice=20 in treatment is radical surgical resection. Adjuvant treatment = should be=20 planned due to local recurrence and tendency to metastasize within = the=20 neuraxis. There is controversy with regard to chemotherapy. The = most=20 important factor in planning the treatment during gestation is the = time of=20 gestation but there is no general agreement on the timing of RT = and=20 chemotherapy. Since the outcome of sPNETs are poor and these = tumors grow=20 rapidly, we conclude to treat the pregnant patients without taking = account=20 the fetus. There is no universally established treatment protocol = for=20 cases seen during pregnancy and a multidisciplinary treatment = approach is=20 required.
"=20 = src=3D"http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif">= References
References
1.
Bodner-Adler, B; Bodner, K; Zeisler, H. = Primitive=20 neuroectodermal tumor (PNET) of the brain diagnosed during = pregnancy.=20 Anticancer Res. 2006;26:2499=E2=80=932501. [PubMed]
2.
Erdogan, B; Sen, O; Aydin, MV; Bagis, T; = Bavbek, M.=20 Cerebellar hemangioblastoma in pregnancy. A case report. = J Reprod Med. 2002;47:864=E2=80=93866. [PubMed]
3.
Hwang, MJ; Kim, DW; Lee, SY; Kim, IM; Lee, = CY; Yim, BM,=20 et al. Treatment of supratentorial primitive neuroectodermal = tumors=20 (PNETs) in children. J Korean = Neurosurg Soc.=20 2005;37:193=E2=80=93196.
4.
Kal, HB; Struikmans, H. Radiotherapy during = pregnancy :=20 fact and fiction. Lancet Oncol.=20 2005;6:328=E2=80=93333. = [PubMed]
5.
Kim, DG; Lee, DY; Paek, SH; Chi, JG; Choe, G; = Jung, HW.=20 Supratentorial primitive neuroectodermal tumors in adults. = J Neurooncol. 2002;60:43=E2=80=9352. [PubMed]
6.
Kouyialis, AT; Boviatsis, EI; Karampelas, IK; = Korfias,=20 S; Korkolopoulou, P; Sakas, DE. Primitive supratentorial = neuroectodermal=20 tumor in an adult. J Clin = Neurosci.=20 2005;12:492=E2=80=93495. [PubMed]
7.
Oduncu, FS; Kimming, R; Hepp, H; Emmerich, B. = Cancer in=20 pregnancy : maternal-fetal conflict. J=20 Cancer Res Clin Oncol. 2003;129:133=E2=80=93146. [PubMed]
8.
Ohba, S; Yoshida, K; Hirose, Y; Ikeda, E; = Kawase, T. A=20 supratentorial primitive neuroectodermal tumor in an adult : a = case report=20 and review of the literature. J = Neurooncol.=20 2008;86:217=E2=80=93224. [PubMed]
9.
Swensen, R; Kirsch, W. Brain neoplasms in = women : a=20 review. Clin Obstet Gynecol.=20 2002;45:904=E2=80=93927. [PubMed]
10.
Terheggen, F; Troost, D; Majoie, CB; = Leenstra, S;=20 Richel, DJ. Local recurrence and distant metastasis of = supratentorial=20 primitive neuro-ectodermal tumor in an adult patient successfuly = treated=20 with intensive induction chemotherapy and maintenance = temozolomide.=20 J Neurooncol. 2007;82:113=E2=80=93116. [PubMed]
11.
Ulivieri, S; Oliveri, G; Filosomi, F; = Petraglia, F.=20 Supratentorial primitive neuroectodermal tumor during pregnancy. = Case=20 report. Minerva Ginecol. = 2007;59:199=E2=80=93201. [PubMed]
=
Articles=20 from Journal of Korean=20 Neurosurgical Society are provided here courtesy of =
The=20 Korean Neurosurgical Society
------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/pmc3_logo_v5.gif R0lGODlhkQBLAMYAAKm5x+v0+IekvHefv+Tp7liXuQBcknmcuoapxDqGrsXP3yhpmrnEzrzL3FqG qgFmmTp1os7W3YWyysPT4Uh4peHn7Oru88TN1ip7p8nS2Rxjl6zB1ejs8d3k6mmStfP6+6zE2Nrg 5kKLsb7I0bbBy9Lm7sfP2HKlwy9tnLnU4pGswaW+0kyCqpvB1bfJ3GWRs9La4A5YkGGcvOLo7a/N 3dvi57nQ3qLD1s7c5pq1y6+8x5+zxLDG2JK4ztXc45e80cLZ5drq8eXq78vg6rXG1HmrxmGOsMne 6WCKrtnf5ZGyy1mKsDVyoMrT4rvGz3Cau9/l68PM1cDJ0k6Stunt8Rdvn2mhv1N9qNfg6dDX39Pe 6n+uyIe40MHL1OTv9XWoxefr76DG2Nbd4+Lu9J+4zRlflNnj68Xe6pexxu7w8dHa59nd6afJ2uvu 8G6Wtufs8OHo8dTb4urt8MvU2+zv9dLc5evu9ezr8maUtwBPiuzx9P///2aZzDNmmczY5Ozw9CwA AAAAkQBLAEAH/oB7goOEhYaHiImKi4yNjo+Qinx+lJWWl5iZmpuclX+foKGio6SlpqeoqaJ8gpOd lVhbVhJee2NAXC1DjEGyWxWvnqqhEHlLG0t5eTkVBG9UFp88ymBCQs/TMXksFRN52hAVMwRg0KPT edXX5qase66YTywe9EYoGgv5GvP19/ooSzy88LAEn74qCaYonFJFgxJNw0BRKebhghMGDJwgURaj TB4kAvIwUZbHDYOQKEg4yHMFwMoFOnRoIAmBBAkUynDmIcGgS4QkFai0a7XpxA8FE04YuCGkQgUw Mno0aFAgT4+mFYRIAOGiiQgDNmZAgTLDBgikCQy0mAExIigL/nA74IEAQYkFKlTe6H3DAS+Hv33x WuDBwwzew9AQBx4wwM/evnBRuYN3yUoCGQVkMDRAgwCBLwkyY66yFMyME1MKqC7wIAEUpxIuiyYN pK3bT1S0LTHBQNuAYi9MqDCiQoWyC8bzSBmhTACDlShGSNEmwAROI8zzqBgRJYKYDmCinZocrLz5 87dD3W3aIUSSJCFqdOhQo379+fjz068RIr78+fz1199/ZAnBznhEVeJBHwzq4aCDDEYo4YQUVtgH hBZ6cEkoZFiIoYUghjjhhxfqMaKJHkpIRijkVaIABSLGKCOIFEywoURIzKjjjjyCiIRQoLR43pBE 3pjekUgm/hlkgkU2OaSSUEY5jJBOFhHaLnsEcYIIJzgpjJRghrnkO5mgwUIZEDiAhANXoLDAFQ6w ecWcdNZp5510rolCGS8QkcltFhRDUkkM4PTCHCO5QYYyGUShDBo5iBRSMUhshIITOJXBhEduuCFS EovmYYIJGcBQwwxAkkLlJUWwsYYWWzyAQQK00npDE2pURasIIiSAwQRNmDGFARj0SusPE7z6FRub AApGBTX4AIMPIXQARQdJZJHBBVF00cUFJkQB7qgZzDFHBuVmQCq65Z5LLrrmqktuFklAIYR4qjKJ yRc0YNHAF0sR4BRUNkxV1VUD93BEV1+FNd8MKQDRxARp/rXQ7JHe5LFCEjAI0CcR3zwRQwxYgKCM BjPFQICgInlaTF15oDCAMmTMoMzGSXSQVapDkenlz68gScUMNcDQaBfiXsDtCBg54bR0F40wghPS Lef000hHIcVFNvFE9QX0QvFGKqsCbbYlYqYNJpUUPtjggx/CXWKEJM5tt4RG/gEihBjyjaLfdP+N YomAB34i4YPXzaK+Zzfuh9qQK1m240BHbnl6k1Pu5eWcT8n4z7063vnoCPpMpAQFbFFLALi0EAAh eqAmQZPpKcEYYyvAhS8oODAmSu+M4QCX7QPYtfsowLuVeSU9bLFFEIIMEQYbQHwQCSFAfLHFDx1w Amgx/k+IcYEyLyTaQTEDbKAMBRSI1MEKeUAwEhEs5OGBSFmAHIPIJGOhDR46SYIYcjaD8PSMMpVQ AQ6ux8BBNOAKf3JLoOx3AQZ0DSdIGMF1kmPBRxkHBQzwSB508BIdjAQJUhiOCjyFAuEoAyPdAQrP VvE5SmAGAzjEQBUewEMe5hCHO+yhrH4oRB8SsQo4sM0wLECAom3rAhmIQBayMAeLYKRrFvRaRqSG kSzypGlTa9rTwrhFE8AgBEE5YFGOkhQDsCENcpBDGqJisDz8AI5y3ArDDDCDNoABDG1IwVkoppaL SfANQpiBOK7BATAQAAo1eM97BAQf/1hLP/q5ln3u/kMfAcmngAcaxfKMghSl3OCRWaEjVazySCgQ QI9eAUsF5lMBs6ClkEq8TTJiQAYEKGMCzXjG8UahDBD8UZimKKY1yhEZydSQElsowR7SsAU3vmEc crBCLTpQlR/IQQiAnMLr7jAsIGAFDH6wHhy+EgZD3gYdZKiity6QqU2VJFSgUkYcYPCoCxghD2WI wLQ24AYmaMMN/MwDGsp1xgqMzZmmu0QPEmCFihZBBAvAgrV+IIKKVlQEGMBBBaAgg4561FdmmM8P MCCBim5BBFWoTQTTw4E6jIQkByjXAmhCgpDk4SQvJIGgUAAdnugkBsVwgA6awwApzOE7BiwdAjX3 /jMkWeCaNYjDHEa1LneRilTmOldY5xABr4JVimU1gdKiEAWwZuE7qCLbM6laJCjBBS98QYxfAqNX vXJAL3z1C2D5qjvPRdQPIIBRjxY7IQqAABOigEKOGEvZyk4ICVCgYUQN1za3va1vnpXb3OrGoLzt TXCgfRviEJe40A7ubqpdrWgZtLjNxna0grNb4XRrotROKG+KjW3hhtvb1qo2tSSqG3FhS4HaTrUJ AoCAZXcEAQE0YaYSIUNwp8tdGVGADDP8w/Lo+iTSmVezDUyvetfL3vZKgg/wja9850vf+tr3vvjN r373y9/++pe+cyUves5LYPEGWMDlKTCBx4vg/mAo+LwMbnAnHmzeCAfjDUoQgQxK+oWzUZh0Fi7K FE4AvQAM4XV78MJLt7C5D3cuxJYoQgG+UAsvpIALXMCSIbRwggIUwQzldQvLlMECMAgTX+i4CzQG Q5IB/GUm8fvLkkmRZMEMU7NTzcQNkEWDAHzgCC2gARCk+QgvsIEGPbiBg28DPmwpww1GgIAKhDAX JaDjBXlYgAsIYLJixCAEvmwfE/qTg5mgwAZwWcFMkpGHkRYolFjeBGa+AAQH0aAIW6ABHOwgBDh4 +tOgDnWohUAHOgDBCiLocC5TMUEmeGCnedgBTjwghpE8AX6iAlkeXLAoJiTjAGVAAZ5RcAE8/i8h CU9YRqQ0UIFI5SELUswZAa78ickJQAVNaAAPQLABHrigAS4AgbjHTe5ym/vc3vbDACAIWQkWgwVo UMEFPxKFWaNBGVJggDKKEzMAkEQARcWJsF/wAjTgmQlZuHcepAY2NIZ3TFl2AxoasIINWLwBCsh4 xnlg8YtrPOPc7vjHQb6CG5jcBUCILnZVMREKehEnEDiANkDSnAN8A6gpGckCXJJnHbCwUNpROAk2 8tOe/CSNpcicBMKwhwAEoARp6aEBwuD0p3+Fh8QCQtWHIEQDVIEGH/BCAMaQgDxgYdWosIALVkAE EyxHXCY4gBEAoAIB7AAAAsC7AwTAE7yj/oEBeN+BDuoub5u4wQFu6JoOBqIDATiHAVGgF9LzdVhL pKYIJ0hAEXlYgBOcAAMGKGIVZHCCLwRRiBiwwhdOsMMioHPlrBZCB8RQ1jnAYIBiMFoXyEg1p0nh 99+6QBeksHupER9pwgf+PIVftShkIA6neni150pKBSilB2nI/hx78O2qbEH7FdgCVybwFRxoPw00 OIsNKuZOVdzlkfdpRiKhwDFoR0CKU8Q/DG4vBh/4QAz7FAf+938AuH/7FwdikHtTlAW31wEz8AbU ZmCVVwmk1EY3wAGeIQeqdDAYSAByAEsNc062REgWg3ZpdxdvYGRLRgUckEhO4RQzoEgv/jgO1lCD QuAZNniDMbiDnhGDMOgMkBZpmlCBpoRKQrCBrDQWr8QVsWQDs6QzI8h+JqgKOKANJIEH4AQZEfgJ ysADutNMo2ABXXgYYChVa1RKAfMaR/gDddQDApMVIAgWM/AwUYhLsBcRyvAEkDQTCJAEhRYziGYD dKEEI2MXeJATL6ACdbEEEGABA5AyA3AXyrABYzEDQsABWzh9E0gJRXAGadAAShEGWPEGMlACarBK PWAaHigCXqAGTdhKBDABY9AB62eH7ZYe6LACRqNWJoBnRhACyZYDuFYHuEYfNBMB95MHRkAECAAB K3A+efAENUAzDAhX0udcm4ABUyAB/lZiAAXgSARgBhiQOlZAGlPwR2BwA6NXBKb3ACeAFVggA7Nw AhpgAFPQfhHhB8qQA40id2QwEkxAcAWncBGgcOqybyNgKeAyMzFwJnkQHPvWVmHzUGaYCSfABSVw BEOQAmVHA+JgBT0wBBrJkXlwSlAgAmwgkkeQAjxkLRXQAxipkWcAejJ1i7fBAcmWBw6AEzHQBSjR BThRd8owAj6FEcqABCoAHRnRHDtwlPqWBwLgBF3wVOCRiTAmYTbpFlRQAUkwHG4AAOMSd0iQeCTQ eFFplhakA0+ABAewA9d2RR6ABADgloLneDpgdFAlV5uIlUFzJBYge7QXLmylNOEC/nzEt1bBB3fc 4i3ztC7MNzVUgzSlgkYcoJdZxpd9eSRU0BTRsoAM6AP7ZIDT0n8C2H8JKC0wMEX7l4AKaH8MKIA5 kxWZKIGXiZnekyR34UgzSAA6uIPj4BnAyZu9CYM0SAA+uJu8iUyWaZtB5mJlGCZl0wQH0F06cgDX lZV/YAHaRZ3cGSLfNUxU0gDS1Z06AgENkDdUMFnkuZ4W8iPYWAmcBVuWRVp4gzagsF0SQp/UmVyv JSIk0lwQZwn5yZ/HZThxk1tuQ1qm5SHFdVwIalyjZaCvpVwNilsT8p6UwKDyiVwQylkKap+fcFq8 NaIH6qAmGp+3JTeKE6CVMJ2fXHWgMLpbqzWiEnIAedMhAxqjgZOgEApaPJqjPzqjd7MiLFoJDYCf 7EkhFHCeefMHkpWkUMogmCWEzJlgLsY5V8mcV4qlB1alILqlkDMZ/zWmZFqmZnqmaApfexAIADs= ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/logo-jkneurosoc.gif R0lGODlh9AFLAPcAAH+apgBSh7+/tkBykGCAkX+cqTBigU2NtkBtiQBIeIi10wBFcq+2sp+qqkB5 ms/KvXCOnHCMmiJ2rZ+srABLfEBwjCBfhmCGmX+WnzBkhEBshkBpga+1sXCKliBgiEBvilB2i4+g pQBMfX+apEB0kzBqjhBaid/WxI+jqhBQegBCbUB2ljBqjGCLojBoiiBZfDBtkmCClBBOdkBzkkB0 lDBmiDBhfhBIbBBUgBBWgo+foyBafxBSfX+UnHCSoiBcggBAar/DvGCEl1B4jlB6kkBxj5+trhBM dE2KsxBYhmB/j1B5kEB3mCBXeRBMcnCLmK+4thBPeHCJlRBXhBBUflB+lyBbgABWjgBhnwA/aABX jwBUiwBgngBemwBblnerzABdmgBdmQBZkwBalQBcmABXkABcl/7pzwBYkQBYkgBblwBZkkSLuWag xgBSiABTiQBVjO70+QBRhrvV5pnA2QBWjwBZlBFspgBQhMzf7ABPg93q8gBUigBXjqrK3wBTigBd mFWWwDOBswBPggBalABEcQBQhQBNgABIdwBOgQBGcwBWjQBHdb/BuQBEcABRhwBYkL/AuABRhe/f yQBMft/VxABLewBTiABblb/AtwBNfwBOgu/fyr/CugBPhABKeQBKegBGdABSiQBNfgBCbgBDbwBU jABIdgBOgABDbn+YomagxX+XoABWjBFspQBKewBViwBDcABQg7/BuLvV5d/Vw+/gygBMfwBHdkBy jwBVjjOBsgBPgc/Lvn+Yoc/LvwBHdCBhir/Cu3+XoQBXkQBUiSBgh0BuiQBBbH+ZozBpjH+ZpABc lo+ip7/BulWWvwBak0BrhSBjjU2LtEB2lY+hpn+Yo3+WoGCDlgBZkc/MvxBdjn+Vnt/Uwt/Uw5+r rK+2sY+go5+uryBYewBGdTBrjxBbi3CPnkBnfiBolABJeQBJeDBdec/JvJ+vsEBviwBRhCBTdK+0 r6+3swBFcRBLb1BzhgBalp+wsgBfnABgnwBemgBVjQBfnf///wBhoCwAAAAA9AFLAAAI/wD/CRxI sKDBgwgTKlzIsKHDhxAjSpxIsaLFixgzatzIsaPHjyBDihxJsqTJkyhTqlzJsqXLlzBjypxJs6bN mzhz6tzJs6fPn0CDCh1KtKjRo0iTKl3KtKlCf18E3lGwx98eBXcEfvFHcKtAf2DB7mnzdU9WgYG4 DqTjL9BArwkFzYnjL0/Ur2HBzikIdaACf2TZzNHLZmBeq2T/bT189x9bt2j9KSDY1qnly5hd9v03 V0EbBXH2KlarVa0/P21S+/En6B/YyQLbkP5H18/b2QXZ1P3Shq3o06lTF6Z892/UtHNSD4YMXDXr 0cFTtxZYe6BsfxIMJ87Mvbt3jn23Dv//pzsq3NJfG9/pW/f5P9kD07I9e95gaILlXTc+2Nc4ddEC zZXeQOuZh1t8/swXW10AAvbdgxBG6FBfeQAYYB6jdWWaeuy1kcceCw7kRx6COJjhQbqNd6F+T32x 1V0p4udPYZv9U+CJBo1YYmKy7fjVdhIGKSSE7MHmF1f1wdVcG3NlBZgEfcFnY197iFafhgb95Rpq wRlkFVjTXcnikk1CF51UVIoGHx1xOAnkkHDG6VSRBWmZpGmH/UbWVoJIKVt2bGUnJnp1cnUYdnxB tQeGOBoW1aFWHprdn44hCt8de9Dh2ptyduopUF9MR6GFnGFYn5YsRuaWiXnkIeVgeRn/iFCMBM2B YY38aarbZLQKFGONabk1KKxhRSVlWrpx+umyzNpkYngzDpQfsgPZOqCjmwpUYh5cQUlHcFU2WtB9 0rK3n5d3sVUYuQHGce2AYnoL7l5S/uNHVco2q+++LNnam3udfcbuHnHwtty7Y2632Ghn/fOXBFtF p6Judv3727l83YWpWcgpV1mq8AIWnSBbNfxwvRLQlS+/LLcskgSDxbHdVFVd1fAdftCVB2Qg/9Oq azz7zFW4A0HpYp4FyaVzY7iiW66usM4xHq4/L5YXHUQLZHRaBMkWtMtghy322GSXbfbZaKet9tps t+3223DHLffcdNettm7+kFouaVYf/xoWgAsjFPhoftdFh4oFtZEzWHkokF1Cd3wxl+GIE57Q4K4V HtoXDRukOF11KTCdl037eq9Yoi+UVl2Cg2X36x3h/XFurpdW+N+3HZh77rebSJAgVfltZNKg59k5 5gVh3jvjnWvLrfDNZ37uHcQeNrxBbIH1ePK1w+79RbKDaBDeubto/vm87d4632Cx4f77bHwB+sRh XeXianoZdAddcSjgvuRgsY36DqK8BMHPfYHAH6kEATr7fYFNjCPdfu7wvDjQwUUQTFBCiocxy33v gxSRne/2NsCFIE9D7NPdP0qkQamA7lwSeN65thKH7Qkke6M7YQnB0kF7aY9ALyzIHf+ydz0eEgR/ dOgczsDytcjEYTUC5J4KQUjFhOCNLeKTUQodokPblbAgq8li9pRFwR8OhFsdROMXUUiZ0mkLLAqD I0LwZ0Mj+iqACKkKowrCFtSAJXpdrKIgaeeP/TWNfF5sSCAHt8jarec0cXlNGys3GsB1zyAF7KH0 XAhJhDxyP3asVJsQsjobUudJcpTiIFdpRdfRsHOI9CBDGrnF9S3IPXO0Shub+A8JsCGHl1SlYdyI l7tch5J+mQMoawQWTXnSRabEW1a4FcU1spKV5DPkfmIZSGESsHuBZAujsLiQ62yPW3mIHiaDycZh 9hBKHyNnROzIQl4u5C+i+Yu7vHn/zX4iUjY1JGEiZ8nOAXbRkLCh5kLqmTsLtsGU7fzmbEIpxbMo dJ6bWZ06F1KVu6zua93sJwhjWRVnkgecPETf+SK6zloWJBDcCugmF0LR6oWuibRsI8YgJsliSsSO IT0IC7fXTH6KdJWxLOUdU9g7lnqzb36Lw9SIqdPEPS8ve1BRTofZu2pS9KR+q6osH/KXLPpwn9Y8 KhVjyZkWcnN5s9kq4W4nM3cy5KtS6U3w2pfWscJ1Dg37qgjzItagGqQqw1vM6MaqVkGyFW+FeesU jRrRxRzwf8EbzkUjOTuECCJ7lpxiAQ93wECAdiB0ud4dDpjJW0JUISy8oPmI6FSE/8AMdQSCoAUb dtu68OxZ1husP9rUwn+kRZONDQpbfbgXyXKxoAM9KF2cKc+EmFORfxxoS8Xa0scNRm+EFCve7Bmg 5BzpdmY1bIV+Kb/JYKpgbZCfWXoZh7Ek8GObSVB0JHCH1LBFOKOZzqKSq5TlwtN9KJ0sCl8ryr6K 85aLzZEu8YLMRw5nMQxmC1pnahB4QuYvhVRIa/Fyvd/xVSB7LRwwFfwVnilgL4EqmgXtNcoVpYqY V6oaLglslOVWSmoJdgje8lWVKG71kdVMWk//0dGEnHjIeeykTxFCz1Qi5HncXU2NsTfcgTC0IPBs jGH3cJVAbO+JYHTXjPlzFxzjpv9E8jMpj3vMTkNmr69CzN/4QinXMR6kjIgSSBg9m90p5Q1FFMWr XQM03I1ajbt4K/EKi1qaDRMEnXguGrH20BrJFMo1kr7xYbYnJg1vdM5A8fFcXcqQ7MmZPPxrmFxT 9tUYUvQ6r7bRZitVXF/FmrsS9DLjIrxqYMPqXAwc7jl7vWDtJuRxEmgDmWmT5JxtCT9tbvO3unQb /VEV1T9RtSETrFL0EWTcDiRW0AJ5HS1aRQH3wx0YURcINgQCNGA6dwPhDUAmJkqTTbZOWL71v+e1 e9Fa23e8rQzPfLHwLospNzTvuD2uxVhrGsxZw4iW3x4O6tvgpgkWRk5ykuOt5CX/txrJoVo4lO8i xWGJwypQvhiUlxxvuyj5ywunAJtjwRX4O5RUbb5zoc8c5Tz0+chpcRqUr6J4eZE5FrhV8qSX3NZC f0bKweIKpWOhKrQYOcsPw4aRuyIOtFjFLp6Rh7C7gmBfWIV8u56yPKziGUzPORagMvIEreLval+5 P3zOd68b/vCIT7ziF8/4xjv+8ZCPvOSVfnKlB0/wcPX5F5jOuC90neZg8fouGIdyV6yCFqDLAx30 Tnk6cH4PfljF5zXP+d3MvuqF9zn+tF5yV2yef7Tw/MjZgvsv+HwVi/NH8G8/9aZ7PXtdH3teyj7y XXD+iZ8HOv/oMHvrM476ez/6/6H8QPJVDN7m/jj65NfP/va7//3wjz/J9UH/+tv//vjPv/73z//+ +///ABiAAjiABFiABniACJiACriADNiADviAEBiBEjiBFFiBFniBGJiBGriBHNiBHsh/XBCCIjiC JFiCJniCKJiCKriCLNiCLviCMBiDMjiDNFiDNniDOJiDOriDPNiDPjiC/RCEQjiERFiERniESJiE SriETNiETviEUBiFUjiFVFiFVniFWJiFWriFXNiFXviFYBiGYjiGZFiGZniGaJiGariGbNiGbviG cBiHcjiHdFiHTpgPeJiHeriHfNiHfviHgBiIgjiIhFiIhniIiJiIiriIjNiIjv/4iJAYiZI4iZRY iZZ4iZiYiZq4iZzYiZ74iaAYiqIIiF1QiqZ4iqiYiqq4iqzYiq74irAYi7I4i7RYi7Z4i7iYi7q4 i7zYi774i8AYjMJ4ivtQjMZ4jMiYjMq4jMzYjM74jNAYjdI4jdRYjdZ4jdiYjdq4jdzYjd74jeAY juI4juRYjuZ4juiYjuq4juzYju74js0IBvI4j/RYj/Z4j/iYj/o4j2HQj/4YBvsYkPr4j/0okAZ5 kARZkAe5kAMJkAyJjwmpkAb5jwKZkA95kRjZkARZkRGZkRZpjx+5jxQZkBKZkSbJkBGZkiq5kizZ koBABmbgBZiACWZgBoAACC3/mZP/eJMwWZNkcJM6GZQreZM1iQljQJM2iZMpeZNMyZRCyZRkEJU1 aQY/CZRCuZMwKZNI+ZMu+ZJTSZVW2Y9NKZVfWZVXeZZouZReaZRjMAZeAJYqyZNf6ZNOqZNe6QVt eZRgqZRySZdKqZY9WZV/uZNyKZhpeZhnGZWKuZiM2ZiO+ZiQGZlSqQZeYAdpgAZokAZ24AVqMJee +ZmgOZWUOQZ2IAZ2QAicSZWSuZqsmZWWWQawqZmp+ZmUiZen6QWzGZpziZukaQe+eZu5qZufmZWE IAZoUAaZuZm6qZgxWZyYaZpv+ZW1SQi+KQbWaZpuqZo9KZxl2ZreKZk1WZlp/1AGV1CeZZAGqNmZ 3ZmVlSkGaZAG1umW0dmdU7mYzSkGZaAFV6AFZSAGqCmatmma6amb02kH8gmatdmWuKmey/mdDvqg EBqhrBmTdoAGVwAHW7AI53maCoqbHuqhY0AI1Pmb1umbhNCWI+qex8mfsqmd3nkAoPCgakAIFroF f5ChyGmaHIqipbmi5okGOuqbHfqheOmc+XkFi2Ce56mjecmjv5mXI4qanFmZaLAIfPAGf8APWoAG HMqbIiql4WkH5LkFOCoG8ombPaqfi8AP/AAH/HAFGwqieemlv/mbJ5qaEAqjD0qhZcAPfxAAgMoH GgqfT4qnZjAGxomk5XkFmf9JqMDppQfanDX6BlgKB1qgmfLpnFrAD4vAn/6ZotdpmtZ5mcgJn0E6 oqX5npjpqE0aonaKmz4pobK6ndxZq7Zqq8yACVUKA0zABOZQDHCwn1qgBZCABmtgrMeKmZCgBX2w qIvQCq1wBX1ArMs6rBcKC3zQAg5wBZAgBvN5qwfwCbdak7m6BlewDUxADStgDm+wBa2QpNM6rMza CltQDJcAqJfAB8FantNarGtwrMdarYuwBW8QAJIgCQFwCdvgAPAar/Kqn4tKrMMar2gADZgADZAA BwGQBD5QANJwCVsgrJBQrcMKpDMJDVqwBQEAAzAgCcXArciKBlpgpZdwsHj/gAcr0AIJCwtbigYk S60Tu6jSuqVigAlewAzjWpPhmrQxKQZaAAsBMAgkQALlMAguCwfvWp5asAYWK5NroAVw0AJMEADm 4ACw0ApwsK/EqqzyarKYQKOtELXBQALU4LKdCgn/qp+wcAkeGwDAaq2LAAewsAVn+6zQmg4OkLbB 2gcOy7iB2woLm6RDO6zVGrEmywxIy7Sa65lq0Lme+7mgG7qiO7qkW7qjWQd/EARncAYkoAeGIAei ELt/YApwYAq6oAu1awp/4Aa8Kwe+awiv6wazuwWi4AaPYAg3iwdBUAB/oAtpcA+mK7oHoA7RC7p4 WQZbwASrewY0oAd44Lty//AIovAGxnu8epAImnAGM3AIrisHvCu8W2AK/KAL8ouhf/AHcoAHm5C+ M0AJh0ANZ/AI7/sGxYulbgC+AvwHxZvA/EAM7qkLj3AI2vALKKAMh2AI4oulCuwG7aoLDmwHxGAK huABq4sDm+AGtHu7cHDAekACZ0ABMAwAnUAJiYAHKKy7lDq+91u8B4zAb2AK/emW1Qu60zvEnouX ISwHJXAC29sJObAJwPu64gsHdXCeZaALW/AIQQAAh0ADZ/C6wOu78Eu877sFdQCfaXAFbhAM2rC9 tgADwmu7WOwGhpAI6qsJiWAIbiAKx2sIejAI7fu6clAAXxzGjyDAvfsIcv/wutr7vhwsu7sLvigc xJxpxJYcvUSayZq8yZzcyZ78tlrwBrJACWeQCxQgApQQDOVwCLyAB+awAnJAtiuAB4NQAsGgCSWQ A8agDBYwAx7QynoQDDMwA8oACqcsDAUgB1tQBlLqyUR6AOvgzJlMCKE8CDNwBp9gCSLAAsbAAv2L CokwCsYwAwNABetQA2cAAUWAAzhAApowBeUgCytgAr67rpLwxyZAA8YACugMARVABTgwA4nAC6hw COUQDIeQCIngAdzsy6hA0JQwA1QrB/xAnnygB7lwBhFwDLigDiJAAkmACoMwCKo8CDCwDYxqoQEg AhBQC5MAAepwCHjgqwH/IAc0MAWWcA5n8A7vEAq+MAtWsM6ocLO8kATUgAoiPQgHfQgkQAkiMM40 IAnLXLTS/MzRXNW4iQlrsAgBkAgn8As9LQScYATGzMssQAKoIAntyg97KweD0AkjYAk4kAujMApm PQNTwAuyMAijMAV4jQd8wKhlAAuS4A6VEAULkALJUAKDIA0wEMvSUA6U8Ak7XQE/YAmHgAosYAHK kAs/8AnKMAMiMAqowNCjIAKWMMwsMAqaQAneLNrvTAIDfQgGHQwPzQvB0NBJoMxlsAZGi9XAHdzC PdxVDcpvoAcicAYVgAg80AhnYAu/8AMUcM2kfc0iAAqN0Ai2oNyqwAmc/7C6F0ABluDcvXAG1QAM iNAIAADYWtDMWA3Nwk0IV3AJ1nwGiLAO69AI330GnMAD6kAEnFAJ3+0IkbC971ABZzAPZ9AJyT0D msC/IoAD4vDcO13gq3vgZwAKllADlbDd84AI6mAN3r26RAAKPFDelXAGPnAJgesGqODcq+sIQ9Dh Z4ACnwAKy3AC210AsJCfWyAL6/AAOtAAD7AAn5DcaD0Kyh0K23sGpYABk7C9FSDe57DdtnAOoPAJ jfAL210BEHAG5S0MFL0GZ/reV43VukrY12wFoaAIoYANZxAKwBAJ+30Co6AH7hsAtDwKjaAKp4Dg 990IKc7fLmAJ6tAMAf9uCz4gB3AwpngABbMgA6VAD6Fw5AAgDJktw4igCGcQ5WcQCaeQ3oM+CZmw upWACJ+wDI3wCadQ3uXt519e3o2ACEWQ4aBQAYNuBOrwCSK+vVUQAPyABu5N3MTdqsZ+7Mie7Mq+ 7MXJD3KQCKBwBghQCDFQCy8gAw9QDYwA6AmA4IwQCpFQCUuwAynACrUw7dXw4YwwDsiADEpwBqRQ CLMAAIPgBvxgpstu7AeACPlu7GLg7IdQ66HACIwQCQwgAzIwCUOwABzwACqADASADCpwBtGQCrGA AGfQDBnwA+ug3IiACMrNCNjACT/ACB+wA4VA8fF+DGdA8BNw8C9wBgv/fw21YACF8PKhgPEGEAs7 MAOGYKNyoAkIrgIqkAoP8A2OgPE7oAjDwAkX4AHSYMYrrAkZcAbsYA9n0AQLgAvKnQAgjwCxEA1n QPQqwA3eYAOkwAET8O2TEAMLEAOToAiKEAm9QAQpEAUPEAKpEAVEMAh/EMT93qT7HvhQirp6cAFn oAiFsPhVjwCOkAkcgPBnQASpvAIrQAOU8AqzwAoLgPFynwmZ8AKF8AAQEAoxbwMqEAG/kAhvwKZv sAlEMAmTIADhoPW4YA2zngC+EAmFQApn0ANAAAJnMA6FkAkCcAROMAkccAQycAbHEArDEAmKYABn AAKk0AQaEAuTEAIq/+AEILAAH9DyjMAA37AAMZ8BimDuNj8P4qAHb1AH+E748j//9F//+U6daQAH cnAI6gAQZxAU4tCAFKkntQohOFNIEcMFhSINYxSKka9IsQpdi6TIUYduZ0QiczQLgB43/MSMYdnS 5cuWBxDBpPlSDL8AiXKdCdUzEqtCjjJdi9XhzAMd8YAgO6MhVSyGjHAhSnDmmKJCAguB+1ZxAdam qRaeUaRoEoFSKgR8c4RBgEaOC45MmtQghjo9f/7kLNLQ0bgzBg7WilCI1SxQh+TAqWNKDqVm3jZs OKOj1AKBijAjSBXtzMFSbknFwtBxyJkjsY5ojeSrYqEQZwQ8SXHoTf+dlTV1y9Rdk1CdP3oukC1U nKGBWJkwFO+V7BUAkWdEgJrFagHEBcqLZwL6ZJIAAQ/OaHIDh19wUDKeNJh0ZpyiYZG+YsgUS8WZ DUCynC0lgNtB/1JJJTNW5COFLg6UWEoe2aSoB6ozFojiDBBiIeWBagqhTyNfnBkkpdx6E3FE3cQw 8UQUU1RxRRZbdHENNMr4QxZK1tGKAw5UUIGbWhxhKBVHNDjDEYl8QeSUU1SRb4ECFzDgDCluQOcM kkzSIwA40HCRxWlw2XJFNOCQ45CdgGGEkYki4q4UIDboISQn7tPAEUeOOQMRRNZBRKBSBtSglEw4 +OorRZpyZAE7NTv/ixRkBAihrUwKYVK+VOrpgIMzLkjEDTfkGGSGM4BRZIemdCTMsEYsSWSxRd6Q hYJKHgCvG29IcaSpUkrBVchSiGQlk0PpW+A0J1JpIrAFIlHlSEVSIUCHSXqhRA5+tPwyxS6vRXGN K97QY4AzMljg0BiGLES5BZJNhgJKEhkkEUooaGSYhyJUBN3sWHHkiXYm0+CDabcwJbhXmlXBiTMi YDKTXN1KCz/9zngCUAzoVI5OAuUrxdIGzugAmSyUgPaBVLA7KxUVHniUPkk7XNUUa7WVeWaaa6YZ xm5hoGQnK4DBZhIDXqilGkUmHEKGaiJkpJFlKLCEAgAawVOVRhjJ/+AMG+rRYUhgGgHAkDcWiVnm bGlGA6dEQD0lz0aSOXIWVRTBwAYVQDjjhQUqgSCUFCo4gwLAX/mlGUfKRYDJSSpgRIgaEOFkCUX6 PuMURibI5AWGEAjFl1mmbgSXDGIgpZRKztHjjT/eMISGM0DRsxcGZCh3B0asceYQSf644oo/DKni jB2Ke/KYBTAs3CpEz0ghBUao9hwXs5bDoBZFcGGaglfWmWCcVCLgRJMAxK65bJnX0GILSSjRphJs ZBiGkwmAOaWRZRHxWpNBDJHDkEE0ccZtv62NfniiHyNkcAYCkEIGydiUKeDwBzzYQggyOEK5hqAI CNRCBgh4QCbGRf+hHQVGEa1BEtwod4YKIEIVswDdE3T0gAakogFxCkctFvCBM5yJAeDYYLiAsUI8 LaMTskjJ2Gx2RDGsQYlLZGITnfhEKEZRitmARCsCEASRGOETn+CBEUQyjx98Yh1ePEMlzrAOUHQC AINgYwGEMYpRAKATlkBEJERSi8l9ohMFCMAWxCZFKE6DEYB0IhWtSI3o5EIEahzFIkcwxuj44hTr OIdIcgEuXsiif8MpIwoRwYNGiMQWLrAECiy5E0tYogah5IQR1mEJOYpABHJUZXR+kQNJ8GELWwgA E86ACk2IoAi/OAMnVPFKAAhDEm9ohRb6wEt8aMMSW1xHJYxwCmz/iMSMFVjHOk4gElDEMo5z/IQQ zFgJIXyCAsIAAC9QIYJvFvMCgwgbGgjpREHek4mGDMAgLEDML/LAEosEAByFUQA8SOISb7iEJGTB ThGAiwIEbaQaLbEObJjxDCegJxxawQd4QCE6Z2jGJH+g0V7M4oTRGQYi9AgAEYxCjbI8wwBmOcca cEKbOwCGRiexhHWgEhQVYGUzkNmJmAIgCAEoxiIgoU+oQjUNU6VqVa16VaxmVatbjRE/VLeCJBwi EYk4BCVy4AERaOIQh6CABSzwCgocYhOeMMQj7PoIQ+RVD5tIxC1A4QIXqEMdt0iEJx6xBX7UAQ1b zSoSyMFYrBLj/wpbeIQe1poIPeiBrp7YxCbYioMBwPUWa51CCeRqWDfgNRE5mMErXiGCW1BCBB6Y gVrJ6gHTjnWvmqCEB3IQ101kFg+G8MRuKTADC9xCD6IwDz+2IIpH7M8Th7hFCURAiUNoVg5/YEwZ ynCeRxS3s2SlLgVAC7jRHkITJQjGWOdK3MzCSwQzgC1m8SCH6E7XAsqI62EVC9mrOhbAViVGHSi7 CUpYYAA4oIAm5uoJuhoCD48QxRbMA4fnEpezmC2uHvSaWbZSQBkeSMRhdwcHN+jhFjMILQVGewsK LBiusn0FaN/q4ODq1RN48ASH+epZEb81cBZwAVzFitlN3EIEJf/IgQjkKty8HpYxxBhwlauMBixn Wctb5nKXvfxlMENCC1eARafkcOYAyAEPa77vmfGQ2UHoQQ4BcIMud8kHPL/BDQEIgCTexUY9SILO fFjEFbQACTAnWtFbFjMc+JDmM3NqoZfYs5ozqwdZtDmhc3bDFmDBhzfIQRZ6iHNC2cxmOUhizWeW Q6VP3WpOvUHPrtbDmt0Ai91dYRGfxnOnXu2GN/ABDoYuw5gdLetLUDrNkiB1nGt9ZlW3OQCT5pSa T03nYG+BD75+NqEPvWhwJ1rMi3g0Hv4si1YzNNh49iOxjc2HZO/ZDZSus56VfW1va4HcATB3qSVh aTaWut+A5jT/sLc9aTrvmc+WvvSo4YxuPu852qvmlMHxPOxvh1vjivZuxz3+cZCHXOQjJ3mx63AF R6fuD3jmQ+pkzfJZA/sPFm4uP/gBB5xjeAt/4FTCZ26e3WlBCyUnetG9O+abt3zlu8y5tkEda9S1 XNZLt3nSY446Wes561lfuZ1BnXVd5lznUpc5Yq9w8t3ZHMNff7mF+RF0oae96jfXduoqPnW2L13s dee6sJuLYZcHG+NDN3rhR450UPM5ANkWO87fbui4oxznTMdw4wEP9mHn+oEKlznZoa7niGeb5o1n utNdDvW7i36XgWe82B8vdMPHXvazpz3JtYB2m+da97ufe67r/yD029dB+Gi/gtpzv7vfw772sRc6 8Xcv/Fz3XvePP/vt5X784s9d+ryn/vCJr/3qA//21k+77oUvfuCfP/jR3372zQ/96/se/r1P/vJn b33jP9776kd/8NEO/f3DveNLPqTLOezTvqpzvO4LQOSbPgSsut1jP/nzPuCzv+XrPwzMQA3cQA7U wD7ogw4Mwf77wA8UQRM8QRQUuhIUwRUEPhJ8wRZEwRdMQRqMQRUEwQ3EwQy0QRrsQfSDQR/sQB50 JiB0QR0kQhJMwRgcwiBswhOMQCiMQimcQiqsQiu8QizMQi3cQi7sQi/8QjAMQzEcQzIsQzM8QzTk wgdcQzZsQ2Y3fEM4jEM5nEM6rEM7vEM8zEM93EM+7EM//ENADERB5MNdKkRDPERETERFXERGbERH fERIjERJnERKrERLvERMzERN3ERO7ERP/ERQDMVDHERSLEVTPEVUTEVVXEVWbEVXfEUEDAgAOw== ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/square.gif R0lGODlhBQAKAPcAAAAAAIAAAACAAICAAAAAgIAAgACAgMDAwMDcwKbK8EAgAGAgAIAgAKAgAMAg AOAgAABAACBAAEBAAGBAAIBAAKBAAMBAAOBAAABgACBgAEBgAGBgAIBgAKBgAMBgAOBgAACAACCA AECAAGCAAICAAKCAAMCAAOCAAACgACCgAECgAGCgAICgAKCgAMCgAOCgAADAACDAAEDAAGDAAIDA AKDAAMDAAODAAADgACDgAEDgAGDgAIDgAKDgAMDgAODgAAAAQCAAQEAAQGAAQIAAQKAAQMAAQOAA QAAgQCAgQEAgQGAgQIAgQKAgQMAgQOAgQABAQCBAQEBAQGBAQIBAQKBAQMBAQOBAQABgQCBgQEBg QGBgQIBgQKBgQMBgQOBgQACAQCCAQECAQGCAQICAQKCAQMCAQOCAQACgQCCgQECgQGCgQICgQKCg QMCgQOCgQADAQCDAQEDAQGDAQIDAQKDAQMDAQODAQADgQCDgQEDgQGDgQIDgQKDgQMDgQODgQAAA gCAAgEAAgGAAgIAAgKAAgMAAgOAAgAAggCAggEAggGAggIAggKAggMAggOAggABAgCBAgEBAgGBA gIBAgKBAgMBAgOBAgABggCBggEBggGBggIBggKBggMBggOBggACAgCCAgECAgGCAgICAgKCAgMCA gOCAgACggCCggECggGCggICggKCggMCggOCggADAgCDAgEDAgGDAgIDAgKDAgMDAgODAgADggCDg gEDggGDggIDggKDggMDggODggAAAwCAAwEAAwGAAwIAAwKAAwMAAwOAAwAAgwCAgwEAgwGAgwIAg wKAgwMAgwOAgwABAwCBAwEBAwGBAwIBAwKBAwMBAwOBAwABgwCBgwEBgwGBgwIBgwKBgwMBgwOBg wACAwCCAwECAwGCAwICAwKCAwMCAwOCAwACgwCCgwECgwGCgwICgwKCgwMCgwOCgwADAwCDAwEDA wGDAwIDAwKDAwP/78KCgpICAgP8AAAD/AP//AAAA//8A/wD//////yH5BAEAAP8ALAAAAAAFAAoA QAgVAP8JFAipoMGDCBEOJJiwIaSF/wICADs= ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/corrauth.gif R0lGODdhBwAJAPcAAAAAAIAAAACAAICAAAAAgIAAgACAgMDAwMDcwKbK8EAgAGAgAIAgAKAgAMAg AOAgAABAACBAAEBAAGBAAIBAAKBAAMBAAOBAAABgACBgAEBgAGBgAIBgAKBgAMBgAOBgAACAACCA AECAAGCAAICAAKCAAMCAAOCAAACgACCgAECgAGCgAICgAKCgAMCgAOCgAADAACDAAEDAAGDAAIDA AKDAAMDAAODAAADgACDgAEDgAGDgAIDgAKDgAMDgAODgAAAAQCAAQEAAQGAAQIAAQKAAQMAAQOAA QAAgQCAgQEAgQGAgQIAgQKAgQMAgQOAgQABAQCBAQEBAQGBAQIBAQKBAQMBAQOBAQABgQCBgQEBg QGBgQIBgQKBgQMBgQOBgQACAQCCAQECAQGCAQICAQKCAQMCAQOCAQACgQCCgQECgQGCgQICgQKCg QMCgQOCgQADAQCDAQEDAQGDAQIDAQKDAQMDAQODAQADgQCDgQEDgQGDgQIDgQKDgQMDgQODgQAAA gCAAgEAAgGAAgIAAgKAAgMAAgOAAgAAggCAggEAggGAggIAggKAggMAggOAggABAgCBAgEBAgGBA gIBAgKBAgMBAgOBAgABggCBggEBggGBggIBggKBggMBggOBggACAgCCAgECAgGCAgICAgKCAgMCA gOCAgACggCCggECggGCggICggKCggMCggOCggADAgCDAgEDAgGDAgIDAgKDAgMDAgODAgADggCDg gEDggGDggIDggKDggMDggODggAAAwCAAwEAAwGAAwIAAwKAAwMAAwOAAwAAgwCAgwEAgwGAgwIAg wKAgwMAgwOAgwABAwCBAwEBAwGBAwIBAwKBAwMBAwOBAwABgwCBgwEBgwGBgwIBgwKBgwMBgwOBg wACAwCCAwECAwGCAwICAwKCAwMCAwOCAwACgwCCgwECgwGCgwICgwKCgwMCgwOCgwADAwCDAwEDA wGDAwIDAwKDAwP/78KCgpICAgP8AAAD/AP//AAAA//8A/wD//////yH5BAAAAAAALAAAAAAHAAkA QAgoACGRGjgQkkCCpAT++8dv4cB/kCD+exgxYsGFEB9KnEhqYUSOHzMGBAA7 ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2640822&blobname=jkns-45-39-g001.gif R0lGODlhZAA0APcAAAMDAwQEBAUFBQYGBgcHBwgICAoKCgsLCw0NDQ4ODhAQEBERERMTExQUFBUV FRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEhISIiIiMjIyQkJCUlJSYmJicnJygo KCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7 Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdHR0hISElJSUpKSktLS0xMTE1NTU5O Tk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpaWltbW1xcXF1dXV5eXl9fX2BgYGFh YWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1tbW5ubm9vb3BwcHFxcXJycnNzc3R0 dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CAgIGBgYKCgoODg4SEhIWFhYaGhoeH h4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOTk5SUlJWVlZaWlpeXl5iYmJmZmZqa mpubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaampqenp6ioqKmpqaqqqqysrK2tra6u rrOzs7W1tba2tre3t7i4uLm5ubq6ur29vb6+vr+/v8HBwcLCwsPDw8fHx8rKysvLy8zMzNHR0dTU 1NbW1tjY2Nvb293d3eDg4OLi4uPj4+Xl5QAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAALAAAAABkADQA AAj+AAMAABCgoEGBHrq0qODgBI8fEH8M+TEDRxWJEXF4qKDAA5UmBw4WJBjgkBsPHkaMQHmCDMQW EofIjFhkosSHMx9ClJmE4hAeZn6gHJpSpEgcZE5Q8MCjSJEkTaI2SSLzKdQkTp82WVGhiRkFJEUe iqOy7AgyTYo0TcKWbdapWKm2zYrVqlMeaeP8MDtihcGwBYu44UDBotYkVKpUifs0MZWrbrdSGHLH gdGSZFeqrEJG5hCpUdtChWt1qlO2U1OzxUGlyJ0WZk9cDvBDjYcZdlErVs02MVzRaXk4GOLHMmCT ZofEGUKFtVSoVKJ/RA39YxHQcKNPxUtFzYmyso3+rlAz4sRV0FW2VHm8GGr658+hznDQHYFYN2VX 3EH8o0n0q9EpVgVcoa2HHWLYTSWRGlRoFt5BFeSxAg8zIIiYYurVtcUWvW3xkX8CDojVCS100cR9 ZVFhBn/rfaRdYgJq11uLUUnn34dRxXQIbOWJhIAbOAyxQhEwKtbFFiY+VYUZWlGxIYbqDTjdCC3o N8JBY6nUgh8f/RCidE6mp56TNyr2IZhNTETkgE3wMAQZZqj0YEFJmNHCEDMEKGYXR7ZHXRMbHsln jGY20UILOKhhX0GH3PFdFXFYl16LiW1oqZQwjmljTTRdtx5Ph8zQo0Ee3DGDUIhJFyifGZJxIZL+ XZDB55FPhpjEoVvgQFKjNeVh4hAYignrhojF6uSlGHK6006APvZDEXFUMWoACKiRBA8rAIghq2Rk uAWRsMLJKqtPAtrECU3U5gGjcbSwRSBbpEsrrLPyyYNFgg6qXhdU2eTZENd1oZhEXTj6YBJk4IDD CiAiaWm46jFYBZ9kyEruw8EG2UJ3ISUSxwpV5NFaEvnOajG/M/Ag5sS0VvFvVTUNkYTDNVERql8B VKCGtBTkubKRAlORL5KyViyrgFKpaiIHHHQ3RAAet2DGHR9CvG+sRw4RpMIqb+jqv3T5lwTLVPSX x60FIVnFDF2FSemGRczQhMkCkzyrnmHCmJj+B9mGjIBJJ5gRaVTkTkqxrNcmUdHcFFtV12kBEr2F zHkkHAAHcZAR92eVsjnxFjN4sLHa11Iha620zjtmRSSrgQPgVbhRo+pe82kGGUa6iXWsRShWl3sB 1itzHGbgEEDjPlda9ZE4VOABa2qdWm+gRuMOZXcMd6uGxyNswaSX9bpBdPW3qxGrGWacP11a/m1x OtFmbPFsHK4rEMh76H4ZncNDjFDBqSdYAWtmBT8O9cRun+sCyI7kB0644QROG8LhYuU+OKHPaH64 HZyKZiLEsIVlt5tV+iDiBjKsoAV5iBcZRqCGnTXBQELr1q04gCjRAatisZJV3GaAKIxkagb+6+lC HljxwCaoIW5C252s0KeGC25wiUWrWJRYBic3lLCFavgBDtxAhZZUbGwt2I12XkirNnEggEwBlMVk da8WnOonCnuh93gAlVjBgixJiEMScMC4KqaPiegLodFup8Hq4XCJgYQTD3jghiGcIBD7QxfepMMq KgyBAytIyQ9iaDQ8zSBlOKhIHCnYRbRU4RRkKYLIeOC+CZ6vhWZoIvksqIZDzqqJXbigwE51Bx48 8iJbeduYJtat1tzGeczBWrdCWZFmhpKPG6zCCS6yhVE8kDhVKELFNEhIQCYyh4GEJQ5z6b1xyqo5 TcjDDE5wB5f17UlTJGA2jzkCYKUvl3v+/CQzFfbJH+QyflRYQXQ4QZYfJKIL2txdLOOXHlqqwXux xGITLxiubYZwbVXwQwta8hQO7KlPRsKh/Dgwg6X8oJVw0iIzPylKhRXBfeY7weQ+QZYhUIJJuZzo zn6AE++5oYVwgmVEhWpRi4WLB104xAqm2RQcqK5Fu2MeUyrAAaRGcZH75BoOHgIu9P1gj9YcAQ8o cQcJ4rCFZeOB0NQTVCY2sYV3iMNPyYDFWNaLT0MwQx5OgK5PHqtwTjqctE5QhAr8z2F8CpLWnokD iYyGM2pwQxc+OQqyzMARkGRZrHDZyhxaUaILrSWfojLUbh4pCT/l6x5XQL1ueSg9uwv+KB85wDdL xQoHRUDovVxaoyC20A1urOwJcOCIyjWhW4Ms2kJjmYfPNtENlQuhINFHr3ht4Q5d4KtauhelfTks ilvBS0rQ5TU1PKRgVVjkV/uEpKEiiqAnMCj9hlBB6nHzdhMr7UMteM/zjRNJec3cOmtylqnJ1XzU y2GaWnCuFQiQaAxab8K2ypz2RvanbkgZJuIQ3zyYhC00y1S3nALRyE60MyjNpWvDxS+gOnK7ZJCs w2aMNdAprDmLVJl/tfaRls6sC1Q4sBtM9YMNizUOSL4IT3FwqJ/MYMjxWhJ/L8ifz6RlUkQTWBXU 4Ict+HKP7preqixGBRoKtEim2yb+QidSEa7CKpAlDBIm8NMCMjQXyD85FEwoVAQ/MAhh/P0nVdyk uBUseauIGYIb4mcoCGLLcIEac8IqkASP0JW6G8xhenGrIqGaWK4pc6BKZkbMyfHwUBVxw1i+9UQN rhlBjf3kRgWIl1pOrjxdWFgCB6XM9PlvBSPoAix1GsVu2e52loqxG5DsRoKW56uB3WELsLW4OAiM YmaQMlomMjY1CAnVKVsr+rpYHlPlSZmrErYZeEDVAEaUiZ+9Z7KrNyviWbEiNA0gtiYUkWfdSs9b yIPAg5hbDwErTf6JmxsPxcdlm6E55TmBUkdnyPPdbiF8q01kiWeGeKcvSvSmGLb+EWWKBwaQSp97 ilMUBqw7bMENmMiDU56lliZY8Q5qaLShKdJmtgBbTqzwK90gulChiI6ukfVzjA8cwvHR+5zqGS4r yMJX83T8Dh3PObCIl4gMWrEJKWuzGQ5hvjjAqwi47Tcd15mfWJzrpQlWdwvlV6G6kpWuPz3xP7m5 zVo2p0S4IAuDhXiHQziCEojXYxywfodFf5HhdxJ2IgKx+EQ44oVoP6n5+vcdvqKCEiSqXSvRt2gE LzfG5vvtiZP7RFlWwcGf0AWHh3AKPxSeEpxwhCMwcYgqBMIPQc2DH6KF1QqJS4qByAOkAiGwIUcq lEOokhp0sU6SKReQbyXqFmT+qexFB9Lia7wg2HnAi1iQBQcx70IgKIEJSuw+D9ujPM7vkIjKmY+c fjiE7eHU+HdRIhGIRwn3swWWNwOsBQtmEEDmY0Gb1VYLdUjxI2zxxn26lFO1xGR+UAslNwIzkHy+ 137ux3selgc4h0j0gyTOlwfog3P0QwaHlwiYwAkbJhOf4AYOpn61IEDpgT4NZUFGk0O2tSFY9FMX BG91lW0O1gu4hx8MMxUA6H7slweBEAjOl3zbBHb44lqoV0tmEAiOcAi45whqIDWHsBcrwAFNUAuJ MFzYBmHV413wBE6/VYFG81l7cQi6sAWOwGFUMm2JAIOWt4ckyCdxkAhjoU3+T8EcQjNkGWRrbhAI k+cIn5AIY/gYwOYXHBAIv6BFRYBsFnZPriU06WE6t5R9keVaKhYvFREMa5gI+BFAJ+SFmPCHgdBC R4I++sdF1vItraEGAodd1OWLhpgInNB7DvYdfREYrAALLfBSOaRmWaY2LTIp4sIZTBRFFCQktMAK IJElfRFAccB7U9h4lrQkG+IiAuNt2UYGdwB87EUGcaB/+XcHP8BX5ZGMAeAA0+cGigM/p0NM5JIY 2dZeqHiE6dMtMJEHvxAHFQAAY9F5AdQFMecHfrBo1zIxMvMfBdNlvYEwfJJzHxlXUghcVScnBrEC h8ALMSFyWjYsApJzY6b+HkgCVByEGz/wC5jwNJhxjw7WBA5ke4tnScRyXM8lcE3XGp3YBcCyffBI f1tQdZ2HMwWBA5QQC6NkVFAyRdYTJarzULsDETNQC6fQBQrALlXnYDxQg3EVjyaSS93BRXAicBVj Pu0RLSQTCBVzB4VXBMcIbAEkEkU2CoiyJ44BJetBV08SWH2SbXdzKKMAC25QAQLhkB/jYEvVApzg Z754CCpkBjZHP05iRelRBC3EHFwUZIfgH8sWCL60VHzlYCMhEAfwA59wCIgmk9KhP0D2QusRLANZ Ngb4CaZgBusyEo1igFVCIl+4TQNYRfSTB1GBJC/kZ26wZTkHKUeEWrX+aIAOVh6wKRDgGQBDgAl+ gBsyMxVjNCYPJUYe8iLp4iYtMAqUUAUUMBDG+RqWeUJ+cFDpkUKfQ2ZO0SWCASm481pddh1m4AhU UCWu2RdSKRJD8AmOYGg2wVP9MTF38AlfkxZUERETkWeZiQMhcRAO+RoMGkBuQAntGS3S4ZkyeSN0 pBjv4z78+BntyAOzBpEPehAHMASJMApDwBRUwUxq8i1a1GYwcS0/sFFmgAldwAGz0ShVMmsr4IIe 0gRxgJ4vt31J1ERr8lIPxxnVWRNN4Ae5Bhv22BctMBsBcAAzYAb/F6QcUB6IUhExgwMkohFURVJq EHNDABaAcZ+WGUBl05QI64FaVuY93XFlOnRcpiMlS+IUzBEIeLJUP8dXLaAAmrqpnKoAHCBBeSCG beJGJHKiKbECdad/rrICndqqjnAHJ2SpQ5KlV/ZV4PIZjfUZPBYvj6EV6TIRnMFkDrZRrzkDAQEA Ow== ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2640822&blobname=jkns-45-39-g002.gif R0lGODlhZAA0APcAAAQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4ODg8PDxAQEBERERIS EhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEhISIiIiMjIyQkJCUl JSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0NDU1NTY2Njc3Nzg4 ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdHR0hISElJSUpKSktL S0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpaWltbW1xcXF1dXV5e Xl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1tbW5ubm9vb3BwcHFx cXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CAgIGBgYKCgoODg4SE hIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOTk5SUlJWVlZaWlpeX l5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaampqenp6ioqKmpqaqq qqurq6ysrK2tra6urq+vr7CwsLGxsbKysrS0tLW1tba2tre3t7i4uLm5ubq6uru7u7y8vL29vb6+ vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsjIyMnJycrKysvLy8zMzM3Nzc7OztDQ0NLS0tXV1dbW 1tfX19jY2N7e3t/f3+Dg4OHh4eLi4uPj4+Tk5Obm5ufn5+vr6+zs7O7u7vHx8fLy8vf39/n5+fr6 +vv7+wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAALAAAAABkADQA AAj+AAMIJCAwAIEQRyh8+EAhRpMgQaL8iBjkyJEgO4I0aZIkyIsXJEKisLHjQ8GTARyJQXmSAIkf FBxo0NAwBgkHDkJ0hBgEhQQJOD+QIMiyqEGDBAigaPIBxQcbVdCISZKkSpMqYqpQPdIkS5YqUaJY 7RnCRsQmMZImReqozNGBSRfEiLHg6ZEoYsrEgdQRb9YoX+LEQcvwqQOCiAcWXfshyYeyX5N8oROF alc0Y49k+fL1axWvWRy/aIImSpAFiQMkWkn06AIUJDS8yKI3ThWsdOhk4bi7ShkxbMR8DSFBA0y1 rY+qLeigSYgXP0pT/SKVKm00nI8kEe719ufNXxz+kxDM0QHctgURL4gdgkTWq6Xxlsn9RftVsGXC ZoliY+aOF60lp1xSPf0QAx1fgJUEeFRFUcZvoS3IGWidRdEVUyh0IkZlCxyFXnouaSBBCGIcQtld Fn4BnBhfSBREEleVwZuCFFCwgw1ErZXeUSEYSAIdYgQZmliVXSWGVLtV9QVnSyYo1hdloBGEBlmk 8huAAiXiFlIHvbDADsJ9wQYa2iVxV177XaTRkxZZGAUaMTi1ww+HJYZYXEwd8cMeTO62EUe+RRkk jGJlkZdwVUBJxx9/wElCLJCUUYV5KW2ZFAU/SACVZ2I+ZFGMCZpp31j3iZUETSj88MNya6kVwwv+ r+4BSRzChWUhjIkGCWVl16Hx4JJo0HFIIons4VwZvLDBBgkCqYSUAwlpoCRnDnZ0RGBoxOGrGE1Y JCpXnN0WWo8QrfqWQAs4EIUGR8SwiWB00Grrn6Tl5+aRysYRXLB70NEvHWh8NAwkWfyQpaWwaQDV fF9sVF9EbMQBMIuSWmRxogmC1+IOHB0BIHJJoXBECBr9UYZXZbCx30YWPijjbVCiETEgf+Tmr83x JkGCI8jc1qFKSUnb0A9BBodiRYeyoSJnHXt7W7ddeSWGDRNVJIGdBByBAgoxYLufhU1Y+HQUhuoH pV57HAKII8NEg0wnf+wh8RcvVBHNkhJUGsD+Akd88EII2ELZ7adenR3uVmWKapl+TXxk2hEdqrVA FR/EiYaJG3LE8hegOGLVRmiYLFgcf6ydTTfYDNMJJDXrO6cz+THbFgEfBOG3hMGF9iKhKC+5EVXA 61mRmYVmEXCqFg4leRYa/Hfkb2CHHdYfvwwMyi3IUCKGvnHIrQw41kQDCi/DmML6HlXEcIsYR9ig WhkLOPYDCpI2AWUVF8HIssZF/m7m8GHbjFdKE4KuHWFSA1GXBmKwAyZl7jZiwQobhsELZzgDEkpD gwb15QpsWAMaoDDFL1IBCMEk4UBf+MERKgWd2sVAOH+6SJk4UpXPaCUJ8/qTrcDypKy8ACr+P4jC DtSTBBsFgUn5mQxmxFWGTphCGciIw8mytag/SOwPjiiWFQFBCZUApgwaSQkbmkATDSwpehbTX4Ok V5WTAaozNpTeZ0wTA7K94FQG4Ru7bHAkDWaBDXwSINk2wUVXSMpQpKPZH4hFs37twRGQfFBwYKSa ROwgJjGwjf4Gpx2ygQ2HVWGDbsJ2tl9tBk2lMdAR9kC1VRFgAUGgQBNQ4Ig/sOE3e2DDZ5YEo7gt akLzAcQe0gaJYkIyESaSWBQakiCD1ZIhDghSt7aiuCoE53PwMdF+fCOzMQXpUA+SUgx+AIgvkOAI Q9HjD2wgxTH5i0VL8tMX9oAklOVGbnv+iJsxaxklNkRBAiITwwtSEgcNhOAD3NpKRRJXhdJhJ1Fo AMSsOpOtMWnQVzLb1mY4RokfjOaVR5CNDVT2hbXdEp5usuZqEvQZvUQMXowa05KCdAQHwIoOIUgJ GhZIv+1JB4eaqwIXE6EtNkiUErrMlbKWKjE6jOlBQbJBExxBBxRE4ZVFlE0ZlrSofrHoa2QTAyC2 2pklKStuexgrklgkHAn8kA4U0OkH0EkrX/kpMjj8Qyc6cYi0baKLtklUyvSFhj2Agq/a0mBw6AAV W7TvlWQkzm9uQysgTTaCJQISWI0XsWHGTTjZkhkdbPKDP+TNEWwIgXPQ8DUehspCdID+hCkoIVFQ dE6XKtKLU+lwi2XcghJODectbXAE2jKLAI45KOlMJganUgcQSErUXmolXWVJRZS/iddS2aCzINDB PI6IA8leALD66TBsTWBDIg7riE2YwhSoxQq+AGaLbVjDGshwL1Ut2r4oIMOV7ROKigBxiO39ga1N 9VUcNsFaFYmyrzDUDzw3Q6ZzsuFncXgBCsAjs+jNqwx/AEUqHNGJVMCXtb4aLBusAQ5oLAMZjvjF LagaJTS8ZBhoSMoOkhACFHAGxJjZamCuCAhiAXeDsjKFiU1hiz18hZTaKsPWsJIU1M7vZJ7RoZvw EmJTJGITqXAFBsWUr3ixOBrQGMb+IcjHC1Ng0RGNcwUlkkICNDhlV0f6ymSEmZs/UCIWoDgEKAiZ 1kM4AhDuHVPhjhSHLHxgB5vJEho82jAibYSHtgLxexFd4neJsnvDZMMythGNWNQSEiFMxSYcQYk4 oCARtuiQBiijgfSGp0F/4AUo4mZFvZoiFrYARQlF2S9t5fIz39xPCDZTBYKEFyqN1pz0wgKWJojh DyZOKyT2Gi9/8XoPiRhxsRdFYlfE4l0vEMMwXukAfb0Ko9zCi6z+oDY6ZJEO78X3LSAhle3161dB +k1Iq+3sqoqJnlaxTNggKFZXgGKYh6CEsG9G5G7TzGZ72IQrfnEINEh1GQsIOa3+qsAuiW3VQXvQ Cy4zDolDHMLcwZabXmyprR9j5wUa0IjBUvIHEiToSC1imX7w44hYdEJfWFydxECNxb4O6xC9pkMi TOGKAhMX5K+cjJRj8JvAsGiYkMgn3OJACUJ2Qr9XHGZXNhSEifzAOEdgAwoMUssQmPeTl/ZME4Mt xWwdgnX66qwjikkJYtUMn1ikjFR5gRoCBOEQX9CAVZUFCCAVFhKAiIUplrS2P0CCWCdLGxt+8JIX SGABElDIODlGAWcDgkR+WVK1wQKaOKTCFpRgLSIBUXnB5LO9kOT9MLuqLDqU4QdsAEVcXtBqnL/A PtpNpTWtoq+05bJlUYgBBVL+LxMNkOA5/yEBClrPc5/TxuYbEpdX9nALW7QFLPjBOIGBz3sr5vPi 1250PtWigU38IaQ1QhNNIX4/UTdBwEcqoi1TswMykxAOgHooMCc2ACsLEQIhQBDFYgNlkEsbUigs 8h1ZkAi8EAvoIy5igS+l83eUwDqM0oKKlFaUESRHIQGolmELNIEhsH2wQgIcY1BQVWNBAH4xwBAk AR07ECdOYVAmQQCJQAdBkAVAAkEso35V0Am80AmlgTEwcyR0UGSshnn114JQxwY1MxKsQQASEHGJ ABJVEAQk8AEGJVVC1GM78CandDI/YIFb80JNoCqvQgIaRoBVxgYQUULb4iT+EfQZlOAKjrAbUMJs hlJY9AYJf9VXLUhvcVNZQsEGR+EA6nUIs4Q/H4ECQYAVYNEuXGMDZnEjrxIDEXEXTsYRO0ACMZAE R5gpkoYRxiYzjLJNeoZFMtIVW4Vl1OFtg+cIUDdM+YRWKQcITcEG6sEGXcRLHmUDDsEoQpQENiB+ GvYcHwErQSBktbQbEbgguyFedFcGR3hL+XJLGQMaUaIV8hFdtHFFidByL9ht8IIGPPYDZYAcTbA6 /tQEO7BjDURie1AZ81NABjIXFvgShnJtUaIzO9BSYvIBVWZnL8CBugJ/oDEhYhNOeHEbeSExLneS feUv+WRdNgEYyIEClHD+CF+RfTHwB18wdZpHGSckfjfSjYB4QIbSES2CAgsCGFkQBHWSCM5IAst4 MhBUPAK0TZxBJpIiWMqyjIykkrcUkeIXUa1CAWrjFWixA8MEZq6QCgmpjSHxEeJ3UCRgKBtRinSA TkRSBXTwMUxoCu0BIbsUJOrHJOGSKISIZYI1H+SmlO64GVESBR/wA3TQCcjhAFlACfsxP0dQOiAG CamQCARpEz22EDMhFF2xTkHgTx5FbVVwCBTQeI7gCsxjA75CbI0ClTOlmJ2SYsiWMrnRexh1UuqY c3FwC1yiFJ3QMKQnGTIChStIk9/3EijQHltzFz2GEW1HlPdBB43HhGX+12NRYEUKaBURVDieITN9 FxweKFrx8i9jEjHm9AFocAuHADISUHkEWRYSgQJ3FAeJEAWwYgPt0WNbAxs7EFI7QIoF+QI7ZijN 9koE4AjgRjfk5ZSFwkM25BViUWMnV6Exc0uFNSahxoaxUAYxMJzIxRf+iVDPKZpjxDUeEQPPMRHP qYqPlirr9CowkmHLgVpNAAikmAS6Nx9KAzbU5kd4cU0qYhVLkxcbRJ5zSXqm4Gp1ghQBoAGUMIcS UAZ/YwMR2C0aNoEgwZOvsjVCYY2wcoQW8QcPuBZt8QF/R4uxWTN5URmJoh8RkxW/cSQdKChno6S5 cTx+dkkgQxAL0Fz+syhLU8KTVAMbc6Gla/l93eg331iQRoIcleIANgAKIvpCwiQYA3kkFNpcbHVZ 3NRv/ZSe4xQDpsAU2cklAbAz6NQ8pAcSfggSfwia3+c3KBCaOqGKPzBVc4ccs0MBVZAKA0peSwV/ Y4JpZONHUokVKbNVVCQYAhUCn4cCqPEWrbIAY/ICDWGNQQiIfziEBjUTzyl+uaoBj8YtLxJRq1op SREC+CYyDMhSKmJ8f5KkiBKRp+Rc3dNUNoEGptA32EqiL5AIfRMnE/EY4/R95xqab9hjNiAB4kcb hQMJRwAy7vpKLzB4HxGRwQJIMuIm0AOYedEixkMr3WN8BRoFrhD+BRcIIkjReA6QLQVqoCRAAQgR ErERgBXYFCHgACSwHWSFBomgAVJaZWeoKZC0NbQBVfRkaZUhFvYTT9hRj9j1A7dICX3TKiACMjEA CATZq1hrUHlogQuxfej6hs9pI5LBUmPVKmrxIQQhATtQS+J3BH6pLzaEF/sxgZAoJGSzH3PCNYeA i4oBF4HqAHrxA7ehKo76GHAoIhIAh7Fxq8+3MlGQCGlxtO8zIJYqTAUkMpH4VZPBBpATP2wUBOOk KkfYmHSwA5FzJ4erIwbxAtxljSPxmQuRettXI5NLAaGJoB5RkWVgHjnibJaSHnXGBt43iviJnypU oEEhFPgZG3ELkoMfsBkve7gCERAAOw== ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2640822&blobname=jkns-45-39-g003.gif R0lGODlhZAAtAPcAAE4xVWw4VUw4bWY4bnREXFpIek5GeGlGa3VIaXpTa2ZLd3RLcmdSe3dWen9h elUsUYdUa4daeJJZbolje5hneZhhblg1hmk5inc4i3s6kmg0kD1HjktLildMhlxTjVpUiUhMl1NP k0xUnFRUlVtVlFxalVRVmlxbnFZXnGRMh2VThWtUg2NUi2tVi2xajGhZiHNag3tbhHJci3VYh3lG lmRblGpck2NdmmValnhZlXFGkV1jnmtgjHRijXtkjHxliGxknGljl3NjlHxlkntplHJlmnxsmnNq mn1ymn1yjEpWoVdcoWteoFtipWlno3Rronp1poY6lJY8lYc0jag3k4ZZhY1EmYtLm4dIlpNMnJtM nJdDmIhWnJRSnZ1TnZZanIlIj6NNnKtMnKRFmLRMnKtTnqRUnbdTnoNki4RrjItrjIhlhJRrhZtz i5h2i4NslIdrlZRlnIh1mJd5lopwiaR4iaJ8lKZqkYtaopRVoZxco5dYoo9PoKRVoaRcpKxco6tV obNVoLtWoLRbo7tbo4xmpJxjpZhnp4V4o5p2qKRipaxjpqVlqaNrqqtsq6dpprRipbxjprxmqbNr q7tsq7RmqKRzraxzrax8rKR3p7NzrLtzrbh5rax7s6d3sbR2sbR8srt7srt2sMJQncNco8VZodVd o8RjpsRmqMNrqspsqsllp8JzrstzrsV6rsR8ssx8ssd2sNR8s9NvrJiDmYuElqaFl7KLmK+PmYmG qZiJppqUrJeXtI6Ks6eIqLmFraiYq7aZqKqFtbSDs7yDtbyLtbuLubWLt6eds72Tu7iXtralq6ek uLimuLi1upyjvMODtMuDtcOKtsONucyLucuJt9SHuMOUu8yTvMScu8eYudKUvNOcvdmUu8ODrsal vcS3vdKivr/DvrW2xbCrw6aixMqawdWdwsmlw9Snxcq2xNe3yOKryeGfxbzAxcjHyN3I0c7S1NTW 09Xa1tnc19re2tfZ2dHLzt3h3eHj3t/k4OLm4uXp5ejq5/f39+HL0iH5BAAAAAAALAAAAABkAC0A AAj+ADeVWbTJUZdJZbDQONbp2zBHk/p8orRHxyFPVhQRs0LpVyZLWLZ4MdQITJkwp8SMuQNGURUw cWYc27VBRJAgSXgUaMCBRBAkJYB0UNCBxa4j49S945VrFw8OBgQkERdvnlV8Vq3G28p1azQvYLxB u0atrDZ00wo58jMp1iBqr/KgI/QnWqpIZSiFujKI1TBGX/6QKjWrFJlBnHQ8+iLnQjNnPEqUCPJk DpIaHXqkEVKCBYsOHpY4c2bv3b13yGghiSyAGT59r/XJho2vNtas86Z58iXsUDpQsK7puXYMT6dQ eIzxMTeJ0rZY0DRFoWRNj6VChbLhoSbtzKlS1s7+nIGUCEyXHFyEOXv2YwCSJVByzUFUogiLICpm rFBgAwgvZvG8I6AttLyRRC4MQDGPPvvsMxtssM1zW1avJIIHOujgkU4gjlwBCiiHHIIOF+aYo0ce Ychyyh/FcNRFBp4k8s0hmVzjSCVnlLJKJGaU4cUXCmESxzLPQNELMk9A4UQNOAWxBBBBsGADDkU4 cQQz4wj4zAQ/yLGLHAyII1uDDj5oW21ZPVKIOpag88kr5sBizDHHkIPOOed8ckgn5mihCiCLmFMJ N5lcgo4lwhiSjCFaYCGGIIJ0wSgW2tDwyAwyADNOL72Mw0wBCDiBwhM1hHDDEjaoYYMNKLBwhAr+ CSAhhxsOHJFELeLIQyaZ/JiJZlaMMGLJFdAEAogfFBnTSCOXhOJIH4BYIQolsHySxzTmJCOMI70o I8yIUYTyCCGlCCKFFl1kckcmc3CBSTPjBAHFeh8YcEMLc/RwQg6ivkHlDD64wMICtthCgQRu0AJO Pvzws2uZstkm4W3JeOIJHlZ84kcrlBijjjCeHHIJJZOgIskh0ZjjCB/o0HCIOdcUcsg6iYyxBSSa pBTNFlM84ksGNLQUjDLLyMHMPO4oIccIKCwRRCJQrMpGG1FK2UIDPVDQRi27MNxPPw07vE+vvk44 jx+cDHNNH4tQ8pYjIF8iyx7mMELIOXwR0wj+KOngccgxeaiDRzZjlKLHJVmcIUYkinNSyAVYZKKD Msqkpgsz9jiBxg0ooCAvDrroUkcdMQTQQAszvAADLu84Mw/YYffa4INlY9VIyMJ08goxnTjiCTrm +OFIHsbAIssifZyTRx7rwHOMJzR4Ms00WpQxyTSOBELK9qRAoociORSigy+/NMOLEksc0YsJJKiR wwk4nCDCk7bIQcJOLijAAQfPeM0P7LCjHdlkMzGsqKN5whhGJzxhjHSsY295kMIn+hCLf6yDGOY4 hyOM0YlDQGN4XGAENKJBjERoIhWrUAUq9hANLWAiExe4Ria0cAxe2AAEJICCCd4gBBw84Qb+AwiB TRLxhCWgYAQ+YQEJePAOfXwNbLCL3QBnIzF8GAcPycgDI8zRiU/QwBigAAQhWqEKWbADHudYxz9e wYc+iOIhV9BAJ6iRnC44Qgyn0AIqBiEJM3AhDhj4xRikIIxdfAAHaLCBZ3ZwAxY4gQ026EEV7CAH KDzhh0HwwQsk84z/RVGKvZqixOYBM1CYwxjGSIY5vMC75L1CFaroRgZjsQ52oAIQYXAWHo6hiHRE IxmdYEUgthCLVJTiDISIxC++MIwZSOEKlSMBCWSwgyC0AQdOOAEK5rAGGaxBAhHYgRHe4IQllAAG E5hPPL4GSin6amLoSAY6yMEEPuVOOdH+YMQnzDELFQlCEqsgRSxe8Qo/6KETfAAFNDBogUYMIgyq gEUgIhGJRZSBE5owgxji8A1kAAEIRoADCuRQxCGwwQdVyE8bqnCAZjghBy0ggQ1iIAckMKNhn4wd 7WgDzyuEyBPESAcNGOGJPJjjCqmIhSRIsQpH/GEV5hAFICrhCUqI4hWfmMYxlDHUVsACFoMpxSkW 8YhJYOISGBhDNpihBhIIoQcbgMIbbDCDAdxABCyYwRtu4IZesAEXc1DVCDrwgiSMw4nsbKc+Biix qJrjEF/kEzHOYbI/yAIVp+gnKQBKCkAEYhCfwBMoPNGJZHABHYvgRjTwIAhVlKIMjNv+AhgWQQZU XAMZcgDC/BCBhhysAQQ4wAEQilAEO7ThFm2AQAOAgAgcjOAER/jBLsbRTrI1bLERs00jLrKHTgjD HH+gRMrOYQ1YDEIV7ZCFIFAhi1mYFxCA2EMjSvSJKxyDCebAxjWiIAZVpGIaYjiDGVwxiFWcIhvP EAETbrALtxqhCAVAAQ5CgIIaBCMYvpiDD1BgAyfQQgZBIEEJ5BCEZ8wDp+6k3Zn8UF9LJIMG5uiD FgbRjkpEQxVksEZ7JSEJWcRCFa2oRBhEwQdPpAOoysADDRyhjTDkqA8YmOgjoMG4M2jDGSpYARxy gQMTMGGleFUCFIABjFvU4Q5vaEH+EW5QBTbIQQY3OMIHXvCGd/wvbNh1GBVtgwpVDCId6GjEMYyh x1ag4seSYIcsTCGJWFjjDz2OhSiisc9y5GFPeBhGH7AxBkGU4g8ZSEUyIbGFLVRCG+QAAg6GwM00 tIACE2jBEBCBjGAMAQ11iMANfICGCEBADXWYgxzmwAIItMEeYcspxCSWjnOMQhCfCIUfzMFHVKwi FrBAhaJnYQpZ1C0Pu9ODKYXqiVf4phuwiMYYxEAFTXCiD6cowynOANtkAKMHTkBEFeYwBxysoQ6I 4EU5CsGGKuSADRFogQ3goEghFCwBEKDDD2pxjztf97oM2jM+UEGGUVDhXJBgxSv+ABGLc7RCFLNg xyxG0c92mIMd/8DTkddhsTwI4xjWsEYrHjUKK0jDD5EYwxlYQYYzNGMXPkDEJZ8gB3z5Qhm4qMIK EGEDNMjBFvNJhBOcYAQoBKEHBEjAB3qBD4vrVJS1ycIn9mkOYjjiZX0wBxkHY44wCMLlsrAGO8zx CT30gQ+/cYQoKjEMY1TDtYMBhDQ4YQYMlIEVYqBENoBBgiMIgd9zeIIvgqGLH6ChCM1VgxruIOw3 gBQRQ2BCEd4AAQAcIR77yOmYll2baRiDBpMwByj4YAw/8CEMq/DxIMRAClm0gh3tsIYk+NB3OJkj HXyYhCiSAYo/wEJxZ5hWHA7+oQNAaGELZ8gGL4rAcDm8oQ7BAAYijLgEE8RACFGLQBtgKoQWDFtJ NvDAB3gABTub/bplIjGi4AdZYAhGdQ6LsHxbUEaqIAiroGOwIAnmYA3twA59wwjEIAzC8CHmgAeG QB3zVgrR4ApZkAm+MAUZIAVRUDkT0AZ1wAYqgH6+IARLoASglwNBwFsw0AILEAExYAt2oAZKggMp EAIkcAC7EA9OhGd6tg9ngg8asEXPR3PrUFBWwF6yEHwDJQl9Fg3sYA/swAgNlAPmUAga8Ak6QAxa AFarUAqt4AoieAhRMAWDcAbfwAwRUAcF0wZtMB9HUAVo0AYxMAdwsAZvBgf+LbACNnBhbzBNQZAZ LHAAJdAEnfREoeSEDmIbqrQonZAOt1MijOAHsTALgxALfvAKbmQNgEA85rAHxmAO6yAMFqAByOEI W0AJW6A9qkAIqBANNMAzYzAGyrALOCAEMjAHtlAHcHAAM1AFN2AEaIAGp3MEunALwKCHiWALNzAC IcACIxABCoAACwABwRB7YMMwDOOEPAVGjrBFhQBG61Ai5tUHEsgIe0ANnsAHzOcJt4MOnbAOFpAx r6AIYSAFrwB8uygJlBBgJyEIZfANvSAC8CMEy/AGIoUDDPAGTNAEQDADaPBgcAAFtOAGiMBwLuAC DCB1azABCUABthAPYcP+MPyQD/uQD2fiBbvjCObwXZ3Ajp8QC3pACObAB4wQC8ZwCFukB8KwDkww JxngB+eQCn1QMtEgRn8wBqcwCNVTalPwB+DAC/V3A0GwDHYgBG/QfpmHKkfABEYgBFWQAm/ABkdA AjeQA3dwC2ywBkLgBAfgBgmQBvYgk/kwmA5zG/hwLqCAIV/kCIDwCRBxCoAgCfMlCX3wCqTVCRpQ CEJlDlGQB9QgQqyAB5wwCVngB1JACqdwCpEABmCwBVIwBbrACxsgADQVDOBQB25wA03gBHLABCjA BBEQATZgekdwVz/AAg53C7ZwfmxQARBQARTQDGU3mNSZD7SBD7AQBlv+YCKHkAjCEArmkAefoAXn UCKUNQioAA0vIwo7qQPxpAPKYjGXoAW+B2DiMR7zRgaldociAAAN0HUeRQQtcAQjQBlNgAMLgAZD 0AYrEFNuNSpz0AZ0YAu3cAu0QAc9kATSJSHVaZP4UA/4EApEuQ5WIAynZQznMGRaYAwZkAee8AmV oArR4AmSAAidcAzJkAzkkAGgQFRXQAx6YAyUQA2kcAar4AVbEAlisAU0sAjqwAwCAAAMwHmBpQYe 4GZMUBlz0AJLsARPMASY0jk2MAJI4AsUamYswAFz9gIJkATOgA/VeSbmAA27JE8iskWwgIF8t3ad MAjsCQqSIAqNsA7+e7AHXGAB0nMM4eIJfkAIp+BprXAGZKAFSnpR4EALAtABIgABEhAAEEABFOAG umAENmAHc3AqN7ADC6dEImAEKkACJyAHE4BcMKACDLA/DNAAzwCntgEb9VAPhxAK0+AHihAKMUMD 6fAJ0dAHh7AcoNAJezA8jPAKplQJVPBiF2AM15AI0XMFrKAFlUAIqpAjKsEJUqADvwB1B+ACKxCc ChAAfTgERjAHduAGcPAGOcACKTA1HmAC++IZMvAGPiABPxAlDNADLPABHMAAucAMVPEOtkEPghcJ rDAJk9A3ngAKWUAM2GAIoBANjhAKwrAHmkBb1PAHZgAKm5AKxWD+CHigDsbgsX4QBX/AcYRACFJA CZxgATSgBcoADGtAAgxwE0JQA9sYoXQwB3VABG+wAAfAAktgUjPQAiwAA5YnBGwwAQzgAh3QAQfQ AAzwAfWyAWP5DvQwmPQQCpSgCYfwCrBgCdIQClmwCcFiDpewDnzTBSInBSdDA5iQB9LwB8PQCF/Q CMLwC6CQB1NQBqQQBRkwBn/QBX4wAF0gBUdXA3NWAj5QAyWAAyRABG1ABCwQASPQAi2QAkDgAQ3A BnUQhDgAA2swB3RAARHwA+CoAAXAACPAAAVgAEnwDPGQD/RwtuEQChnQCX4wDZ+wB9UQC+iQDpOg Dp2gDlwQDaH+sA6PEAXUUAbScA2iIAzXsAiNgAeLkAd6sAiDYAZWUApSsAVf8Ag08Atc8AUDoAvI oAJ04AaRwQNL4ARAcANwIAcngAYUEAM4ECU1EAOiagdsUAs3sAJEoAIdEAFQMRQRoBO9uwG18A7z cLbDuwWEQAnTEAbUoAiLYAjD4BuxEAqaYL10KgyLoAfUoAp6sAWIQQ2Q6QijMAmDMEy/gAmBcAXT wAmPAAZYEAdxwAXNgAwTQAFrUAAfUKBKgAMRMAdusHBwIAMrIBQsgAgFcwcU8HksEAIm0AEwcAAF AAIcoABgCwAH4LsSMrzDSwmqMAxqOAut0AV4YAnfgAVa8Ar+25AO1cANr1AJ1QINoaAHbFEJjUAR jfBBxMAH7WiaxfAIc3AFvwAHhwAGwaAOwEABL/ADE4ALE3AAAKACbGAHFGAHONACToADalAFLuAG dSADRFAFQtAEg7UELBADH7AAKgAqYZurCQAAyNDBcqwFrLAJqJAFr6ANlZAFgUANezAJ3RALf2AN 3EANrQANWhAKk+AIYQALkRAIleAKG6EFeyAHAjAMVsAHm+ANiZADmTAFmgAMOYAMyBAAH9ABRxAM mBoAaCCEdDABCEcEbPADMNAEQSADMjAEMeACH4ACMdAAHyC0ngoDvMsADtDEBzABziC8wysFnNAI 4ZANA8X+CZBQBtsQBqDwCpTQCucAC9awCVBJzYqgCWpbBuK8CXlwBdAkB99ABkwGv4YgBqPgDVzA BcrACwUgAAsQABNQAQ3wAz6AA1CgBiOwAAqgBlTTBCfwAj4gBDYglguQAAMzAjfwAr7cACzAAAeQ qwyQBMtgtnJsBYaQCdngC9OwDa+QCn6wDY6wDbDQDdwwyCH7CtEACnpACZZwDIfgBZBACIMwDMWA B77gC3+bDa05BlNQkL9gl4UExbDiqR9wkkGgCxRQAwcAzCAwAiJQAi2ABtJkA0FgjFUQASxgAjDA EwYQdgXAAxMADLmCD3JMD2ZAA5GgBV8gDYpgBqngDeH+sA2t0A06d7ItLEJdwAibsAiacA1dgAp+ UAbDEAfFoAxDYAnukgXy9gVlYAfLMAcY4Au8YAAdUAAEUAEVEAABsABpQAsUwAaSUQQ98AEswAZG QATOhQJA8EMSTQIg0AAlcAAI8LQTQAu1QAviUBumwcHe4AqwYAYCdgWuIAqc4AWusIbUEA2K0AWi 0AokdFWeoAlBNQmEAArf8At/gAXqEAecQANcoAmKwAWPQAb04Az+UAXOwAw/0ANnXdABgAANkAYG wwYwkAZXxwYs8AIT0IhAIAREYCVIQAdrAKovACvK5QC4AAxy8KbvIA7OQA/vwAqYoAyRAAmRAA2H 7Q3+mxBeN/atiwAJkOAKimAJxJAFnEAM0OANxUAMxAAG9HkIi5AJxZAJX+Bkf4AB/lAL4JAIwMAL IPABIlADHFAAPQADHfDfPxADWD4HAusDE0AERCADQsAD+hIEQDAHaZAGSYu1FJAACaAAGb4M+ADn ziAP4nANjVAMhy0LrNDCrcAJyQAO3dANrYANwxANZkAN6/ANKEtQWPANl8AJXTAMydAFoYAFF5AJ wzAAYWAGLa4L/QAOVTCMsG0ADHCwPrA/RKALa+AGaVADHgADJ8C5DA0FPLDlL6C7MLAAGWoLuBDx sKYAYScO9IDs4mAa4BAHHTEJ3uANXTAN1PAL8LBzDtSADWKABWAApImw1C1iBp8ACdPgDdeABcJg BVkwCYugBZRgBwJwCJJwBo9gBlXgC7rgC7TAAUpAAg2wADLgAV1rBLvAABHABg3AAyggAjMwAkDQ A6QOdh9QAv1cAL2rAAtAAf+NCw4gARTXwcguD/MQEAA7 ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2640822&blobname=jkns-45-39-g004.gif R0lGODlhZABuAPcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWlpaam pqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5 ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zM zM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f 3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy 8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///yH5BAAAAAAALAAAAABkAG4A AAj+AAEIHEiQIIGCAA4qTMiQgMMFJLJoKlbt3Dl0GDNqzDgOGi9KXnY0cEiypMKTAkumZNgQocuX KQ8abOmwAY9J4/b528mzp8+fO8dpEoNipMmjCR2uXKh0IcynL5UmJbCAhSZ0QLNq7bmv2yEWRpEi pckSatSVZGMSILFo3Na3b/eNoxTkwtGmDZnmNYtQpsykLEk2qFINrmG47jiRWHC3MWC/fPmedPhB Uzy4+/bVO/yWWZQGjB3j3RvZpdO8NpIhPpct27hx8TLXQ2fR3WbO8RSHxtsUZcuyT/8aXLiAybm3 8cZVg1YsGTRmzNB1y1atObRs59y5i1fv8ltoVUb+7lbJ9HTpvmrFuNO6Lx7tasySMWPOrLVz5sB4 LYdWLdv0brdpFc8hG4gmFU3mBRcYSWesB9Q+0lG3XDHAMFMdRdUBQ0uF0DHT3HLwdYNObOyVAsJ4 Jk1F1oGRkbSAF1gBVY9yFkIjHy8aMgMMh7zo8oouzfHSYzLVLGdha+OgE6BP+8zywQJTOQYYcFD9 pZARx/20jzs04rhjMT0CSYtzyfAyy4+60DILMEA6l02H0Lm2JFeH2CXWZHoJd5ZfBNhQmJasWZjM LGkSygstOG6YTH6zoFKKmrN4iaOHO1ZYJGxZuePFAijyqaKeMFlJGS9AxTNdNc4VQ8uqr6wqJC3+ uuB4KC2vcNKooRR6CWtz0F2nE1DQMCFeY3iSdNZwAEBAya89nQPic8XoMkukpbyCSqJsrtmjtZyU goq0vFAIa5pAAkMkM+fMyRM0Wdh5128szrRUQgugoS46NsqXTDLRooLKmaWU8qqGr2gIMCWzlHKm Lvmtiooo5ZKZzDnM+uSOJixwSqyx8aLVGwFIZMnTPufYCGa0O84iSsKvvDLLquP6a60omogiyqNr AnMmrZzowi8wNgKTDToVc8ULD52KpWBMLDDDZDc/9ximLqho8vCZWE+rJieacMLJIzW7/EqPjkqL CqJDAlMMNNCM4450QAFjA6dJp4heTABcIIr+PxW7w2+YasLaMievrGytv9USGvAkmjzyiLfeWuvt tC4j+mV8FbINjbr+iOLuxsLpqdACcMwp16Jaw8pqKV5z8rDNk4jScuGiTPLIJJNQwsnNATv68ssb uqoLw8211k3R/qCDhMZ1d5yXQyhk8xM6lDr8bymUVK27zai4THjCMn+9SOuiUEKzKGfTOq2Z5I5Z DEXZ+PrTKxuABvpAoCbUgCBaegTmobUqhSgWkbtFWA19/3qFJmZ3QAJSomuUoEQpCNgtTUxOTT1S G6X4o6Nu/KQebbDfxgoiKgKwwINc6QYzerQh8NGMEo+IoPkK5zJHqQ+BEbzdIwwoikP8AWz+j0gg 8BAVLSI+h18x6kk2kNa8BPXGDj9xR3NW9TLsvTCHsRPF7qoFqe7RihYP04QDbfaHQyxiERKs4e8O BaRizMc59WHWr3QBFqpIaSYKQQE0fBIPVAmpUJpg3O4CeUbG6c51aaKimqylicYxrmqCeAQeFvGI m8kua616X3OIJJ8kjowTHxihVCazgENUbB8mSxMLUcGJQzbuDw+kZLdWpqbuvYJ1uquVGTkxiTYI woyH6JotAzat/GjIjWxbm3d6gg4xhGUsJEzIDnLSk27kh4WEAmMrG3fGP8Sulbt7mY9struvgU+M Z5wk7sA2CYDVameI2lCFyrS2ou3Dcxr+exdkHHKBV+zkV+dQm+XMRAvs2Q53lFjnJHbXvR5BjnWO shrjarfDR0QyoQ+8mctk57JEMWxRYALG8XwCjR3UDX9RqsIy/REPaQ2vUIy0nTdtJ0kK/otQwLgl KwPWSJqh84GBhKEgtoc+Ylbrfa2iJzNglQy39CQeIdRnX3agC59kw1raSmStbieIM3L1D0P119l4 YVR/0YyVkzCjJiJYvkUE85aREyuaOqo2MMVqYj6ZxYk6tZSaHGJJ9dAF+lols1u2chKLwMM6BcHY 7K2PVja7GQxhaMAdipFxPPwXObvGOptZa1cgNRMwnMqTcwThmcbCGwE2IIqKdWNmC2X+KOwQi9hD 4AGYwYzdj7oXwXLWrqsCRGzX1qqJRolCEGC1gyDwgAY4wOEPeKDEmOqan2JQk298W8QFGDMejwHA T1wBBuS6JUigTuK2eMADWCu6vcPVSrKMC6QYG0c+b4lREF6Ighf2ywT9ZqENXvjDml66L2BUY07d YIIN3qWWM6zUHdXyUaMsGEHbuRW6doCDHTZ8CPRZsHZeI6cBW0mJMi50Eo5i3SHskIX+VuEMWciC F9BwBi/AQRMMc+kmmbFSviUDD6hVCwH0VrGrCulsVdOEbQ9B2z8swg5i8EIbziCI3DHOiqVYICXG 9zUdanFlrYRDG/6QBR5UwQtZgDH+mqOAhEMASUjGFFIyPLmTbngBAuTBnwn32JNkjMtateLEIn7o 1kcc4hFwOEMUeIAENBgQggeMHSUXar6b8XJlmoCDGGiMBCOcoQ0yDvV+OREuu1LIjcxAYbPEgOc8 H+RFIuPbCsEVUU38cJ2OOy8akEACHjQXbNhrZSksvEOfPnCipYDyGc5QBSR8Gg1eCIIYxFCFKohB EzhaFC/ko7lq9LgekyDBWKjCAlHMKRvS0ugsEgpL6JrxEdAlCghIoN8f8pR1iEUj7npY6UYugsbQ FsMZxNCGNlA7v0xggo17tq99PWc+1aCzP3iRMY4l5QJwqEbRxuEjrnVry0wO5CH+mGxbMcwbBCjw AmPJ660Sd1V3w04jJUZ+BmnXGA003vQZ0JCFKGyaCWdYRJso8pznXLe0ZxC3xQkAATSMtCfjIOvi epvrxsXwEJu2AQpYYIQowCHkDyxxGWNYSTFKsBQrPgMTsnBmNWdBDFF4Mdur4PMzUKKu8OlPMrrx bU44kzwE+AAnVpqZahRUZbdjcu5i+MsSw90GLGAB5OHgVkoS8A9tmKh8YX7eGUfB52iwQxTeLob/ lr70XqC2HV7xPmhRKOI/YQYaUGDxBQSBGUWrR043GsH0RtJ2kUQuHLKwAxKAYAYgoPK/0wtvPOxO i2FnJYujwOzREzz1M45ytaP+EIQYp9kOpdjRH4F09J3EYxFiQNEF2lB+fwT0TDdr1MgPEfxJEhAP ZWbBB1iAAjH8AfMZtlyCsEBrFVwqI2b5VXdeUGNVwGmb9mKpxwRIwARiYAe9FUGoIDQ95g+6AAcF 0hQoYBk+UQ+D0lnoUzv0B0tPpniCkAWdhgIksANS9gd2MEm/ND4PE0NcUz6bJnAN2AY+R3d/AAdV 0AZ48Gyl12LWVnBjxgljAntWhQZB0BssoAtF4w4+gj1dwwm/JHxn9HtnJHqRNwMssANnQIN2sAht kIa9s1ZFxQlilgU8J4dpVm12AGNM0HaKhgT7pV9oIHCUx3ptMyfugAZMsBv+EIAEfNYscGVh52VR yPVLt7Nlg1YFH3B8NsAEcJBedvB/f2Ar0GdBWfYIm1aHcphhRtB9f2gEnkZ3Ewh3AgdjbdCA4Zdq DjIy+NVqgWcHpMUT2ZBlD2Ro52V5NziJXCMIVbADLEACKFAFkqRekfQItCJAvYM9f/CHChdlzQVg A0dtSugFCSdj1nZm04ZmeJCByZANt7gTr8AEtJcQLLAI7lAx8cAMSYZOXWg774ZGEcQ6j7cBLFAF gmCEyGU7N4MKCcU6XoN/cphf+TVwCgdg/1UFRhBj++UFzZaHctgGSGAHODY25ZcMRoAEJIEEszAn 6JAMW5VQj0h2v8RkXLP+CDcDB0iAfCSgcovQVZS0QN7zOKXwCJxgBxgZZWznX3xIhNfnBRPYBnCg lPolcJtmhB1GKJujREGwKQTQAF7AC4DFHLRQO4h1g4snCHZgaDFUaX+wAyiAAiDABL/XLQLUMgXF VuYjCDW2X2hQBRQIhNT2lGKgXkE0QI+Ac2gwZmfQidF1O6jgSeOABFVQIBDQBsywJPHQMAq0VrYT S8hFSWkoTD9pBB+AAjPAA3igRQt0K9P4kwulCUJJd28HjlI2cPtFZZMQK7tyKJqAB2solGA1hEz5 CIvoD+5wBkiwYBBgB9mwJOcwTjYTQY0zWRUlCM81gDejCW2gdaIpCGH+JFZnczDNeQg1tnOftl9i BmNoIAg/siODEisUsm5wUJjOpWFryAnBGQ9ZMANTCAE8kAxL0g1qomSZCVSOo0P/R0lgo0VwEAQ2 AAI2EDsqw1GlMDw00y3WQglQ1pR6WYfL5gXgFy44EiRCglS5SWObOGh/UAq9aJ8zgAR5MwNcqURU wzXCxEtWxjW2lZOD9jiicJ0o8AE8ADaiCGgvwzVAWTi25n/MFmV4eWaPUDDhwi/QkB+L8jMDRIN4 gFyH8AqEN3tVEHgzQAsVMw7AwD2+s25VulZYemiTEFxokIozMAPeZDWtcklmggpAqTuosAg7l19v J4fLVptqwz7V1Rz+m1QNOdUokzCEbnZKf0ACZ9AnRlAMFYMOOmNWCYQ+GCVG9EdAqzmYO2AEovkH cqpFLvMylpSp9PeHcshczTUJ7hOl7dMcUvpG/AJG5yUIpMIVlLABTAAAaHAIwLAk6BAtjeIvXcQ1 CUV/h3BsjxOUPMB/M7B6YrMh7vUv3bOF4MlzMwZgeBB+/AIdIQokOgImDqc2+ZFpQvcTnHABTEAA TPaiPOE30tIoD+WGN5NW+kZbOxoEPNCvXgCUYLQq1eIt2nQ169YGPNdoa7gIGXgymLMjDPMqPnNq bsQLXYN7PiEK+rkAUcAEr7Ak7pBT1RJZFOotZ8OFVYZGjcQJWQD+eTbAA17AsAGbNa8yO8WaqPmF BsDmMuwZHx4iJHDmI8OzY2Q1C9DQY4uwAShwAVEQj54UD35mqt0iW56FkLkWQ/7CBCCgtDaQBTKp MDc1OT2STQSbp3ZQBXjQKj/pL+GqIeInlw/zLfFhJmfCC7EWD1EAAQ3wAWLwAXDgSfVQDNPyO8OG Ygx1PcOIRgpUBTPwAcy4A4KAPtJiPd/yR6siLYx0W6syQGJEoT/CC99itVtULUCzLyFVlTsBDKE0 ZFGwAYKwjvFAt7+jMl6DgZBDCReVPYtQfDagoDNwjmPDQgoDtBoyr6XaSI30k4yHPmu0O+fFZObj LdvmHPBBNaL+wJ/7YAeh0QB1IQiAqzOtMo1hxDUPszsseUiCEAXIt5Y8wLDp8zIsFKKXKzNZBoyl QIPjUzn9oqmYGUO9c7mqUlBwQAvd8agkURR/ALhLNTwyAzDg1JyOsz1ihATLGAQzsAOHQEwtMzzF pDbaNgs7iEtd40OH0D3f4iONJEhnGVsWVFCIwh8OEg9iYEertQBnEGv1AA306i+E0zIBUzjmI0YH Kgp4gHxkKHnOB39n48NDuygaMli1Qlux8y+Q0jJrZSvgNGyVJDOxUg0OohPx0KV2AQCMwQN/shP1 wAwBY2kWZMJzar7xlVBNO4aQ5wW20jK2VDWNsiHvIy3eYjP+z3lJhtUtbNudM5Nl5lswe9c3JLlg JLEBtPBPfAMN6nMm26RRYJRlQ+VvcIB8kreWOyAGu9MykstKhSMwDZMwJos9YGdAaDRWppbKYvMt bkQxUGcDEHAGu9EApjQy1eDHxYqsniVZkdRIeOAFNrADO8ADjcsCZ7CFgxQrkvMoEmY2CYNYkOhD YPMjtAAN//HNy1Em4WIhdFYN/EeSLhIFy7QPzFAoYNScXbWFCbXJksR9vcsCM4ACNnAG6DNLa6oh X+k6eywkhUOkO+RWQwUxFZIdGBEP2qEd0pEMbeLFPgEM/ccCakEC0vNPlPwtYJSDtAU2XXWWFooE FCx5/Gf+BCW8RVuULQxlLdJcQ4j1NS/JsMyQJCOiHfHAHd0RD+dQJj6TDStVD7QwA3ViEg0wC/+0 D9UAaHicZWj6khZ1aJmWjDNAApHXazraj45CrI7CSgwFPK8QdvT3e6jQDRexHTvNHWyNDm9SXb3I UpoQBIswEoBBOvUAUIeSNbdSOwaKXE6mp1lgBDbQu1tXBWfnNZATLTVEYQYEMzzzNSZGCa+Qjmnt 0NvhDufQDSYjJNHhE+dgB+DJMQ5hA6RFglRDKC0zLdfaSvTnOGW0awqKBCgQBdHlW9VSMMWKvDCE SAW12jO3Q950LdUwDhdhESrERk+6NkuyD7pwBrPAAnf+AQFKjV3+iSbF+tXcNGgp+2SuqKAqZzWt 08OLgqzDRVwKEykTZkAFWTkT+zfdMwvv8zPZMKlEiAq6WBL1ktc7EbJiPbKtNNXwRnaYB3RpJmVo dGn+UlwEzTudhZmFQyu6wEtrBUM1EznnczNMdWpN5RPVEAS6uXRUET3YtQ/ZEDiNQuHIK1NDlajo Z6XLyksJ5ToIuStUk8cTCoouI0Ba1C1mOVwy6SqXUyZz5hPFAAfMwAON0QAQwAm/AiEBhMi1WzPB 6E2Wp6wPFGI76Ci2ot5/7C8ZJTuTw0hmyjW5o0WRUl2Kokk81hMQ5jIXsCCv9gFRMI//xAxwFU4B Uy3+JOY4+yhLuwOUDMXj3wIMAi1z0Ys9q1ydwRhDtBK8sVJdk1J+0BAFmtClqVUSbBnJ2HUOD3o1 O1U4Luk4koiZ2GwrjvJlPqMmmKsy5tM9A/s65JQ7ueQjsCJO71Mh5Xd+YqCxeDIVJDADVXCL+6CS kaM+Alu7B+04nKq44atNXjMme/wyeMxKtPIwPANihMNK6RMraWIu88F3XPEKIMAJmO4bLsIDKMAJ JT4OPgwpg4sKa3pYiidTiV63p0y6gkVY1VIzHBVZ3FJJrmMmfxS8hLp3CGYDSFAKY5wnCrEBRsAD pBUPgtsqL2U2CqNFaLdDIAdz08IwCvTVEg058Qf+6ycIUV8NUUR0wubCL260jnwjCBvwCm2QIk5B EiwAApqgE5lxDkIyRLOCVSi4Q/P3ONI8PIejJqoC6+FErzYjQIRTvxtcqgVTV3cVazvBCx9QBckA AjePIF46A4WRGSTjEfEUJqy9bodmRl4lO4Hj7REepQ/zKIYjO2e1MiBcpKVKKNFCIU5c3xZTBf2E Bq72PEOWBRCAB3I0IxoCZ+IUUULlNUElOz5iQ1i1KCb8ld5CyDeTJi1juPH3Mv9TKZP5EwwvBryw AY+xIgfRAB6IAsUgyXwzDnaVY2fSSDJ0r4cGlLPQU9nkM7wAaJs/oQnjhPE9M90JLh46PHHtD93+ oO68QPi8AS9JoZdauR5PnsZsojq3JEMPfoGPxrzixyYKRMghBld4TwsUusexIis44jM9tg+TAAGC MAv5Pf0fAwKUMAMXsCySTDIAUYzWq1mzSonipGmRJlSoSqFCOOkQJ126XpXSxSsjL4OPRM1CdXGW KEqTMA6kpQvkLI3AeGmkBSzbPn81a1azMYMXEgIACPT0CSBo0J4/CbQRtIBFNZs162XTVaoUwVec RGnihIrWwFevRD2a2rArKl3FioHUZLAUrZCoNFEqxasYzIEqZ80FlhfYuab+6sG5QCmpT6BECQ81 umFSkAZ/6vmjSdNdMYelDGqSavLg1MtWRZX+Spg27yuHFyuOdMjp1UvWs2jxel1Ml8tkM5vu0wUC CTAUP4kWFQrcqFEjkzYE3kfTpjtgIAdeFSUKFSewlmmVgjvp0STpZEfSAjmbM0hUrnklA6ZLK6/0 LZmdU25znJEPnMQsOAy0qHDEPqv8uQCFYpKzaZ9zUAKJk6ke4sQq8LZyi7tXwJNLOoJ0oQUzywia pSKXTANmLl2SYaab+JxaBAI4BGmgP9+Ac5GwBuywAwIk0KlJuX26sWggy2ahCqQJM6LlqrYyAqah jyw66LPVinGJvfDmmqsadE6siRYSquCktxdjjNEoACA4wwsIDklOx32q4aWhhzIyiKO4VGL+SxOG pjKroJCAnM61CdkDJiXYAK3tsb52NCIIUWx4UTj9hIL0y/0WQIKJDWYhUMds2BoSytcuEoVIiEQh jZZqmHFNoNJYYs0l2cpir5hk4OurpnG8uMAOIxo1jL/CeiVsAS+MmCEZyArcB51ssqlGL40a4uS1 qP58rZpqCsoLJbmYYQZWEmXlNpt4ToxsnCw2yIKJBSQFFsbCfCVgATF42IGZY++FzEBm0itSJI3C wrYaHlGRC8OtzMIrGWgEjqceQ2v1x502PkBj1+GGyq+/SNsloIEzbLCBKXzjcycZ8FzLCE7SXimL mWZnAcZklfKSKxm8bIN4OTxQqMJL3zL+Dg5jSIN+dL8LzmCBiW6OxTLifTd6KSUiaXG5m2bPkzVK aYuBZpx4craJGTQ+2OECMdl91zCMiz5szJ6DGLDpHOtx5xxUCTqZl/fc4Rsdv7N5OuauxwXbqVJQ uCCID4bbr1e2NyYabQiYAIEEVHQEu55xgLmKk2Lgkzuec9Cph8DCbYXjODEWZ5xjjX/9lejDGpgB ggvgwDHHWnWs+8rTf7+NlhkW+IAJEr6UHfaMYxc6Uv067riKakzfXW7gT4+HEhAaCCIIsxl/dGNH h2YeRsd/gmABFB7hS3frrz+9HmCquIAFJFg3f/mhkw+a/P2Da5xRGnABHszia2B7H/z5xoEKJGwA AiwgQQPGJybxuYh5zeNPBeMFghmAgAd/4AWtMAe/WtWjGqVAQ+3w8zPkKe9/anth8/zXOABuAAU2 uMAFZoAGXriDhLepBzqgUQovfECC8SIM2voHucgtMYZOfOHPfOJBG3xgARvYARxKkYxuuENNpaOJ 6LLBC1HgwQtM2AEILiDBK1oxgMDSX/ku+MQZvk4oCwBBFexQhR1A8AMk4MEZaCSGLBSyDW1Awg5Q sIHKsSALeIjC95AIQHcBbX+OCh8M6fi/ohWFeEZAwyEo8Yg/oOEMhzwDIaMQhTaggQmsfMR2JnGG DfwGAAvATxOZmL8KAiAgADs= ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2640822&blobname=jkns-45-39-g005.gif R0lGODlhZABiAPcAAAAAAAEBAQICAgMDAwQEBAUFBQYGBgcHBwgICAkJCQoKCgsLCwwMDA0NDQ4O Dg8PDxAQEBERERISEhMTExQUFBUVFRYWFhcXFxgYGBkZGRoaGhsbGxwcHB0dHR4eHh8fHyAgICEh ISIiIiMjIyQkJCUlJSYmJicnJygoKCkpKSoqKisrKywsLC0tLS4uLi8vLzAwMDExMTIyMjMzMzQ0 NDU1NTY2Njc3Nzg4ODk5OTo6Ojs7Ozw8PD09PT4+Pj8/P0BAQEFBQUJCQkNDQ0REREVFRUZGRkdH R0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZWVpa WltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xsbG1t bW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CA gIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKSkpOT k5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKampqen p6ioqKmpqaqqqqysrK2tra+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4uLm5ubq6uru7u7y8 vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvLy8zMzM3Nzc7Ozs/P z9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e3t/f3+Dg4OHh4eLi 4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx8fLy8vPz8/T09PX1 9fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///wAAAAAAAAAAACH5BAAAAAAALAAAAABkAGIA AAj+AAEIHEiwoMGDCBMqXMgwIQEADyEKjJggAcGIFx9iHEigY8OPGSFWxOiRo8aTHjcaPAmy5UIC E3aIYURq1jFq15ztSmXJzZcdEy6anOiyqNGXAE6cmYUunr6nUKM+vRcP3TFQYlioPMq160UfqdDd k0q2LNR0v+6MEJjggkWvcBtGRPEpndm7d+99A1WjI4EEExgweDghaNGtEuMymPMNL7pdkBhRG4s3 ajpQLEQSuICihhI1OxDHdfkQRiunZdG1uuNDwwUGHT5RFUeNWCttlMuKmzMhIoMRNYj02SJ6NEgi 13JPZWapDxMWI1DAmM4CBqM7O1igGOFDzy5t1Kj+uZN6TxWKiQQ0wFASRchb4y07fhGnXN83Qj6m 74AhxAeLHUrUgEJ/J1S3H39C7IACEbbUd40SAyUwwg4KnmBUcfGJYVdU1DASBQs1TKeED0T050OC JNaQHQtE+EBhdihoMMIsZKHzBVET1hBYSR9h+FECamz4VDytCHFCDUIk6YMSSSZIBIVCEBGcfzsQ wUR/CbIAYiv1pXPjRCfkd8IJPDLko5lBRnUNayqemGSLJfqgYolKKAFgfzv4wESdV54onR6/KIcO EwNNAAMRWnYQX1cEfCGkPsQIMWCVSV6ZYA0h1rCkEEzAOaKmCbIXRYsCjknIeFNpk5lAE7AgBHf+ hsl1lHyPRsqCm052SiEMt5YY5RZEEMEkhW6y1ykT+bEw5iCo6nOPLRewpYEQAmp1kF8J/HWmQ0Q8 +o0VKiqxJ59R2KkikkwKEcW6TIyKZZPsjuiflif0gdpTkDAgEAMo7HDCBYoW9JcPBJ+4w4VJXRNV PPgJIa4SwrZb7g5RBtupuESUW2eSdnLKxJ5xuqgsCqks/IVv/12gQcAKEXHUBLZEdc8nVVopbqfB fqonyHuOurHPQhwaRbvCUlylnAuiE5U4NUA0AWcsMMDCBRgKcSEjUbljCYV8tktwifvdyvPFDpfY aYImsgcxwe1+nJ0qUs3SWwKw+XACAzDom5D+y6QR0ew9fWCa5NBWjGhif5ryyeeSQ9uMJYnCQkxx p1YAW0MUSkPlDhMX7FARCvlNMIJoBFjt0gXOUHYPKLwu+XG7n+5XcIk5i1q4FR+XW/CJLnKMu5VR yEnIvfp8AgM1USQwIBMocGaQ8iwQGt8iUTHTJgw+RIH7iHnCoCK1BG/8usSwu0lwkyPWCbylPlgB CTFjUXOGNvEcQwgRVhAxggYaCNzBCHz7CAOY0Kx4fKhJJ7qSlJCEpzxxbURM2ELljDW0iqXLYJxS QuEkpyIYjGAEW0iOTZw1CND8hwEAO0gAG9IBhUFlEx0AkLAqGCxQ5QmDJGLSFobGwyUJq3f+aIPS x6wQJRjsQFMEO5Qb3OGOVDRGH7aQmnYmgILeFMR0QrmWG6Iyi36Va13qIwJ/SHTEExnOSkyoXLmI tjaOOSlJd2oRGYlVMSKQ4hd2ooY+xOEfJXgwAXe7CBZfggJmQEUcMFhQ/vR0oh8GjVQUw1W7vrCF StZpccFqkcOUdMMklrGREftQAraQjnscwwqzgEQNTpAAGFhEI4NUCAG2gJp7uCFMONsYxwyHIiBC TF1WINwl9RSlKNXMRbuDUpXyZDOb1WAEFziVKY/hDj2s8gKZSUClPtIBUjhLH7uIYbBM1EgFjkiT QfvPpsTFQ4hdsmzh456cHMg7YTmMnV/+yB+1dtAKy0AibyNg2QoRUhElaOMpTDsBk5DlsN7V6Xwn MqJ2tKQnYwnroi7K09os1SZ5LjRdGUvjuogYPWaI45A76AAB8vaQgR6kAzXQA2VakQBKXRROF31X fvzVgQ4U6En9+Viw5OS9H9IuPyWywvlyFrH84c8K2xNjHx7VxcCEBgCxPMgEtkCjp6TiAuVk4z2t JEdqPfNpGpDOJmuWyFtFMmS5YtI6IYbGOkF1Cz3DnzOytoUqwsBCWRUYC8TwRH2oogMOG6kCI8ee /vhqlU/r6Qj4Mx3qdKZKIIsTM+2ZvRlWNLFR2AIlJRggPUhFFRDTQFakl5AJRGEQUfn+hAYyti7t KdBjwdulfwTzNGzWQDsouKxn1DWuGzLJZlCt06iulEYJWuELXxDDDpkgBlDcKx6pUANiSbQQpRAD KoA7AW0lpr1RQbVPOQuaBhiQgP91IJGSXSYaG+fQNWrPWG6LXDCfe4YzqGGHCdorVHaxhR1coD0k uUgConCqsyg1gvZlVxrHZbb8aec1F3iasvjXr4hN112VGlrPNFgx7DnsY19QgxrOIAYxWIFCc6DP U2zBAj8K4UuJ4UgHzrAL8EIilCJukeLaFSX24NU/rsGwB1FYVO2d12cJHCnG4Pik4AxRDCzOp2iR 5oZrOOUaoYXBBYhzrQT4YBHNihT+cXdYwShBWLlm2+GT7laYC8CgAwxQT8bwKsGPiatsGiycr6Jw NB9IULRb6C+Lpaug6nwCHcTYxByCeWCEEGCAMRvSF8QGVe1tQX3t2iDsKqnPDrhGdCxIcnBCG1q8 aoxJ4grmUDf4yxRLVwxuUIOLLVnkmUDCCtJ1QxTUgBAUnuGkT2GGGYEMu1gfd4iiLZzd3MIvFNwN m2nEnRguhlGR5m6kQ+OzdPP5hTOIFrqUJNoX5oBXdl/O0iggBHgXEbGc9WmNsBMWsNZ1biO1BaYe nEBalbDD6YIaYqGFXavLZQU3nCG6EvyCG25NyS9EYQQnWJd0DT0HdR2kIjXo51P+vkEi3MHuxPuV 4BoLF8HnvrgDE/jXdDoAMP5EweI81OckR3XRllvhDHfogxqiW+6JFxzLFgKAIsXwBSLM4QysJQjd lOBCfYACQBpkV4m0R0l8kzfiSoja/3I0AoEvz7ld4/oWCnYzdrmhD3dg+hkmHl0XD/sMayFAnmqw BaanOAoHEYwVUOOOArfdyTPkIfDAiLsobPsEAj9Bv3wQ0CMF2tkPWyOWcicGT7fYxUzfgorp7uKg WWEQUdCAxHXthi08D4V9gAo1SLSuDNK2cs5leeM+1nfm/e8EN7wziIRcW5ZnvWKcEi2WfVLuFT88 umrQw8PP0DghzOELopP4w13+XxD2TsCbT1HFekQVLLwmP+LAIv+eiTiCW2EvZyj4D3FvHky6CnWf REixoisphv9G2w13oAd9cH19lz9u4AYZlmISh2MDoQHtpUdPYQme4XiKlTGNx3VaBzHPtQUehD0s wilS4li4M1o9w2pXgilK8Hmd13+hV3cS1weLEHcsJnoT54B6IH0TZxA7wABCICSLMEmVdHMQx2/P FSyNM1IAFiJ2UiKf1ib4Q0mVczaOMydMQEktyGZ+h2Vq4AZzMAdqcAdnoAQAKAQTkACEIHRgKDA1 kABWoDp3gF+451xOFl3sNEPicgZxkiTrgT8LRCJV2GkmdyVyhTgUZAX/pYX+/adi6zYIejAHfaAH iigEHQAkK+YTBdEWAKAGmiMG+KNyamQlpFY5vxNrUMWJOfNAnYIkSxJMVuhqwYMz+xRHjpeIXahr lPR2jagGhDAIbpA/GkAAZzAHb8eARGFaT5EOT0JehFM5FqcGJjdOENNyFLZsulQlKQhsfQZGD2VE wVdy/oVrd3CA/bWFwphig3AHO+Q5c3AHXUiMHgFbx6hUysVndzVhpPVt2RYgS1IwH+MxCYJZfSda DpM/1kgt3vOPIfVclDR3YAh0d6Brc0AIc9B5UdABegCA/7USAGAJUPENUbKBQQhunRdtQhBMofZi 1og957UD9/ck+RdxpXj+Seh0Q/hjW8zofNrjBoPQB2LAji7XKXoQgNsmMB0BfvpADVFSWzyURlrG f9s2LhIUIiDoWAknWreFP/snYpf0bMDTeKJohUOXf48YkXPQNkrwBXrACH0QJR8HN8kmLCl3aHw2 NNBlcrjzaSCCJ2bEZhuoVCwJbBD3aQ+1QeyCVwoJcUQHbGfQB5AAiXdARGg0B63gDHoQQQIDESXz FL+QPVwnUtEWepW0Q8GEl3lJLTfjYmnkYlH4Mf1XSV/wTtEYjSDjlKIXkGegB5AACotwgFbAK8Hy Bc4gDmIwAVEHEQ8BCgNWknWZRqQIVU92M+DSfkckHfpmWwSXbTwXfQ7+FzzuJFTdKV3KB139JV1z xwiW0IhiECBGRASMgA7XkBmx5Bcc+RS7oC4tFloWR1sVt18SUwMrUx13xpJt45ydpnJEgIjBlJTj 0p1K+XPgqXxzAAmfwIhfkCD90gfjYQtB4VIPAY/60AqG1pRRaFd9Ni7Bsz8+FVwnEGoJ13hfMC7N pYiNtUsmGS8351xQuENnAAnaIA6pgCi8AgOwdQ9z8BBZ9RBbFH5Wgo01inDA8zBS8jRH8le0R4Si mFxfVHStBzLR2HgSA4hQBYXBFAVYow+/0AGdMR0xgw4wwD8Q0n0AEAWUAQmcsoH0RzSRkztPUnYy kkgocJK8Z5WsZnH+BMd0I7lcr4N7+bQ9ENZ5IOMDXbULgOQic+AUrTBZMFCcANAbMIAqoBBr0BVB pDYuZVMiHnQCplYgjANsuFdef2iT6NdsPaNlqElwonhfiLIDB/WhrYQkexUPfbAWE+BSZagBEOgM SaJlUGhuQ8MeTCUgGBdQNeCZziVa9LeoBMqUu9d2LDqazMhyiKIGlPEJDCAg1KMP2nAHVdQpBiFw BOCW6AAsFZd7Julmo3IiY6JOb4afUeBflaQGDFdbAypSTMJw4lKi3tqsCiJy+qAHGgB83yUOgyAG 00JEBgEbmTgW98AIegKFe3IsOWNySVIglFJ8TOd4bqAHVthcCUf+fyo3LoKWdXj1op22bf7iA8jm Dj4wAR1ABL+gDT2hBBNACNyxEmtRAxtCDFUSheelLozlrAmCPeICXaIpWgDIi/tVOKElaJ2ytW2T MXAZQba6qFdyAuL6FNrwiyygBqAACnpgBcrDCJxyEL94AcdwjGIwf10bjeVSV1S2lPj5eYMwsXiV M+VVj1c6ph/baUwZmlfCAkZJCpuxBZCwCT2xXn1gBQTgUpuqLx5KCjswpl6JjT6DMRQSOfnkc/13 js/VHrbVLpVEBIeWbhEkiPl3Vzc6NEuSOfFgBQDgA4xguYugFeJipB8XLTWAKuJwO315aBlTZKTq ZwXIiubYi4f+W3CE42QQVqBK2VznVlufIHsy4muL8AXtpTcAwLkEMDoT0GP6EA8d16rMqHLc2jOp mYWUpAZ90Is7pEGhBpfrQm6hZX8DepfnhjsCpg/5wgRzsAiLMAcO2DQDwbkAgGcAcAZQsTVq55qB CWexqX+JmWL7q4GVw6xtU3zQNZLVKmIR1JRbkDnpkB1fcAeEwAhMsFIs0FMrQ8F5BgAawAxjcQ3h 0nwQ93znJYj3u2ItVm7CCLCikmXSpbhQZW53xZdE6IlKQAiUoQoaoEFf0AeDkGH+UVmZmhAooC93 ABWzUCWJ1mJ9l2XlUpLNenNY9nQsxmJxF1q6RpGoyTP8FoT+oleXTiaXMPBd+uAOVrCi2gYDBCC0 BUHBAPAbSVFY2lCWVRhdP+dqx8IpoTWOSgxdW5hPnuasohyIfTmS4MmiUFgDYoAq0HI5Q6MVrSIU kAwAIzAY54pQuPNcLfZwRFRbD4NooqVoK0aAXKdB0HleolhwTjlazDqCT7Q5HSAqfUEAa2gQtSw6 Sods+CIEfYduwAKEudO15dZ//nWA6amQxZen3quYUKhxbpw7CQwKE+AD/eU5BOAGX1UmgcURjEwA m1A9jBN6y3VziFcic8eCdWxu7DFuFpc/dWKtO2SooUe9+ekGCfwN/qkE1BcU7buxFJGUC2Ftv1tA akAiiMb+txyMV9S1f+t2BxZXhUMTxYS5vbv8xuW2n0ywCJnjLHNQU+0SLR3wBZ+APBhREbW8qT4A AAkACRwyIiPlpRKkmvY7yPqbnmB0oCOZbQdsmCy2YkQHLFMVFaqgMvwRLQmwCPGQDm+6EUlNAFVk y4X1LK3GdKLaZ67ZvZ3sBkP0otd4kgtZrYCJZffJ0bv6FNeQN0cSLQRwAjCwCKTwHgQByb7RFwBg jM5yD5tAlxZHdA8Nx+1Cffqne8aSuvzmd56of24cWlX3vidTIPqyuZlxaTkWEbUcEabmwxB4jHNw lrT5onT8cAR3x+XmaeEGbrCrmoqKZXVZJ0b5FOTKs6/+BFWk8zRv+hKjAwBfoBzaoECdPINQpWIG 3F+C6qUt12rkfdPDLF1XYgU9fQ/OsBbZIhBKoAeSrWCYsio5FnhrwQDPbaYuWYqzq4j8lr/CNpqf FsChGcVL7GTOSERCYMjHqAR+ARE7sAgqJSv7rVVB0QEJPHKgkLlY+q+6xopDl7Kw63KjFZoBiW7j 5mLscbdQEQ9uUBIrpQZJtyiyFBSN/Ciydwetdm4PF7hbEI5VTJ5UXK0nG5JXcgaTEVuCMREqgr7w cRFfIBZkoQ0/AZI0i263CYZ1KZ79RUmxJl2IemOMwM2a2T9sISDbEheOUhbOwG7WOr/PFYBCF2pW SLX+bGaVT7IDXwAKah4/5wEma3EYs6IGzSIzkNYHdHXa4SiMUV3OVK1BKStdm1BY4EUMhQ4RbvEy s5KJiy4V8TALXyC1Z0AIkbEIgzBpIkWC5eUGQFwfUXGmhTI6b17lBBAFak4W7sAMv8AM781E2vAJ 20a1p7cJu9Dr5EEK0QIRYZLrVT4QO7DblWEW8eAMPaoNuFEZRELhrPJi0j7tE3EBkEA8157uZoGU E1FTX0AmcDHuDiEEsxAPtK7ulXEP7rAJ/fMX0WMt5O4V2pQKo47vdxEPtiAEGhEm2R3wo9FKg7AL PW3wUvENm+AeENEvGa7rAf8XI8AEfdAKzPANPm45FvdwDa3QB0Twi5u6MoPh8LLkFRqRZzzLkomm aOsYlP+lIxrRFhlW4R3vEDC/Eh4BGDTHXkNPEAEBADs= ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/go.gif R0lGODlhJwAUAOYAAKPE1v////b4+ff5+szd5naQnqS2v7PJ2Pj6+5Oyw8ra5XOMnPb3+NPj7OXq 7ZytuO3z9+/y9H2bsd3p8N/p7rbDy9zi5pqrtoGcq4eisb3U4Y+sva3E0aW0v5ayx5e1xpOzxZaw voimt5u5yuPn64+tw+3x86TF1+fs73+YrNDc5env9Ku9x6a4waa/zePr8bDG03eSpOTt8rLF0tji 6N/m6Z2ywXWQobHM24qpvYKftLfQ3qzCzoWkvN3k6LrHzoShtIqeq63I15utusXX4aC2xeLq8HuX qNvh5YWkt/L1967G1LnFzerw9NDa39Hd5rDAyb7J0XSOob/T3e7099Hh6q3L3L7L0Yyswoenv5W2 y5q7zpCxxqfI2p/A067P4HqasqvM3X+gt4Oku3yctbDR4jd3fkSRpAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAAAnABQAAAf/gGeCg4SFhoeIhGaLjI2Oj5CRZoJmZZaXmJmam5uTZ5WcoaKdlF+m p6ipqqurnmZhsLGys7S1ta5dubq5JyFOAwFKDbojLBEBCBNWu8xdrgDQ0dAZNQhTPFcBVQAfLQEU MFADVNLlAK5e6epeCQYBO+kbRDheGCgQ6e0BGuv9rlsAA24R8SPAFhAuOCwRsqVAAAIBHUIUKNCV losYtQBhEkDLEQsBAsjQsiCAAowlT2bM6IqLy5dccgQJcMBlDB8vuNxw0MRlkgc0YQp1haWo0aJS kAyYYaOCACNYdFwIQKNIBwErjmrF4iqL169ee6SIwiCACRUevEoYQiKAgCclOMDKzeJqjN27ePPq 3bvXlZi/gAMLHkyYsCsyiBMrXsy4cWNXYCJLnky5smXLriRp3vwokefPngMBADs= ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/pmcgifs/wm-jkneurosoc.gif R0lGODlhFAAsAYAAAAAzmZnM/yH5BAAAAAAALAAAAAAUACwBAAL/jI+py+0Po5y02ouz3rz7D4bi SJbmiabqyrbuC8fyTNf2jef6zvf+DwwKh8Si8YhMKpfMpvMJjSIAgErVcrViqFyutNQNS7JaLRmS PTfOakW73RFH2PME3I6fd3VhKnZrIodmcHU3RYg4GFA4tujHx1i3mPgQaXgYWSl403e54MkA6qa3 9xXYKXpI8TiRSug6aYWKs+lgKZlpmyha5QVZWnkBS7nal9P5J3zqq3gAStdMbAtM+9oY+7yLK72W y1kbqpwsCz6DXDYOUkgdDr0W6xwM/3xuSvLI/E55mRavuy9vHhp8w06U+5QnIDeEqgbm+/ZQnz+F 8AIWtIcx45ACADs= ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcstatic.css BODY.pmc-body { MARGIN: 1px } BODY.pmc-body-table { MARGIN: auto auto auto 1px } BODY.pmc-body-figure { MARGIN: auto auto auto 1px } .span-content { =09 } .front-matter-section { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .section-content { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .section-title { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .toc-section-title { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .back-matter-section { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .footer-section { MARGIN-TOP: 0em; WIDTH: 650px; MARGIN-BOTTOM: 1.2em } .back-matter-section { FONT-SIZE: 80% } .section-content { LINE-HEIGHT: 1.31em; MARGIN-TOP: 0px } .section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .toc-section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .banner-color1 { BACKGROUND-COLOR: #3c78bc } .banner-color2 { BACKGROUND-COLOR: #a0c0e0 } .banner-text { TEXT-ALIGN: right; FONT-STYLE: italic; PADDING-RIGHT: 0.3em; COLOR: = #ffffff; FONT-SIZE: 135%; FONT-WEIGHT: bold } .banner-text-sans { TEXT-ALIGN: right; FONT-FAMILY: sans-serif; COLOR: #ffffff; FONT-SIZE: = 120%; FONT-WEIGHT: bold } .banner-generic-logo-background { BACKGROUND-IMAGE: url(../pmcgifs/logo-generic.png); BACKGROUND-COLOR: = silver; WIDTH: 500px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 75px } .banner-journal-publisher-over-image { MARGIN-LEFT: 84px; MARGIN-RIGHT: 20px } .banner-journal-name { TEXT-ALIGN: left; FONT-FAMILY: sans-serif; HEIGHT: 50px; COLOR: white; = FONT-SIZE: 20px; FONT-WEIGHT: bold; PADDING-TOP: 3px } .banner-logo-with-journal-title-over { HEIGHT: 75px } .banner-logo-with-journal-title-over-placeholder { Z-INDEX: 1000; POSITION: relative; WIDTH: 390px; FONT-SIZE: 20px; TOP: = -75px; LEFT: 105px } .banner-logo-with-journal-title-over-placeholder-content { TEXT-ALIGN: center; FONT-FAMILY: Calibri, "Trebushet MS", Arial, = sans-serif; HEIGHT: 50px; FONT-WEIGHT: bold; PADDING-TOP: 3px } .over-logo-journal-title-sageopen { COLOR: #0055a5 } .over-logo-journal-title-sfesd { COLOR: #ffffff } .banner-publisher-name { COLOR: #0032c8; FONT-SIZE: 12px; FONT-WEIGHT: bold } .menu-link { TEXT-ALIGN: center; FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: = #0000c0; FONT-SIZE: 13px; FONT-WEIGHT: bold; TEXT-DECORATION: none } A.menu-link:visited { TEXT-ALIGN: center; FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: = #0000c0; FONT-SIZE: 13px; FONT-WEIGHT: bold; TEXT-DECORATION: none } .menu-curr-page { TEXT-ALIGN: center; FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: = #ffffff; FONT-SIZE: 13px; FONT-WEIGHT: bold } A.menu-link:hover { COLOR: #ffffff; TEXT-DECORATION: none } .header-link { FONT-FAMILY: Arial, sans-serif; COLOR: #0055aa; FONT-SIZE: 110%; = FONT-WEIGHT: bold } .inpage-link { COLOR: #004080 } .sans75 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .sans80 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80% } .sans80b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .sans90 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 90% } .sans90b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 90%; FONT-WEIGHT: bold } .sans { FONT-FAMILY: Arial, sans-serif } .sans105b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 105%; FONT-WEIGHT: bold } .sans125b { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 125%; FONT-WEIGHT: bold } .msg-error { BACKGROUND: yellow; COLOR: red; FONT-WEIGHT: bold } .msg-warning { BACKGROUND: yellow; COLOR: brown; FONT-WEIGHT: bold } .eqn-image { MARGIN: 5px } A.navlink { COLOR: #0055aa; TEXT-DECORATION: none } A.navlink:hover { BACKGROUND-COLOR: #ccd8e4; COLOR: #0055aa; TEXT-DECORATION: none } .navlink-box { BORDER-BOTTOM: #cccccc 6px solid; PADDING-BOTTOM: 2px; WIDTH: 675px; = FONT-FAMILY: tahoma, verdana, Arial, sans-serif; FONT-SIZE: 80%; = FONT-WEIGHT: bold; PADDING-TOP: 2px } .navlink-box-black { BORDER-BOTTOM: #000000 6px solid } .navlink-box-brtblue { BORDER-BOTTOM: #649afc 6px solid } .navlink-box-dkgreen { BORDER-BOTTOM: #006666 6px solid } .navlink-box-gray { BORDER-BOTTOM: #cccecc 6px solid } .navlink-box-green { BORDER-BOTTOM: #dce6e4 6px solid } .navlink-box-ltblue { BORDER-BOTTOM: #9ccefc 6px solid } .navlink-box-slateblue { BORDER-BOTTOM: #6c9acc 6px solid } .navlink-box-teal { BORDER-BOTTOM: #9ccecc 6px solid } .navlink-box-navy { BORDER-BOTTOM: #003399 6px solid } .navlink-box-bcwm-combo-blue { BORDER-BOTTOM: #639ace 3px solid } .fm-related-articles { BORDER-BOTTOM: #666699 1px solid; BORDER-LEFT: #666699 1px solid; = PADDING-BOTTOM: 5px; LINE-HEIGHT: 140%; PADDING-LEFT: 5px; = PADDING-RIGHT: 5px; MARGIN-LEFT: 10px; BORDER-TOP: #ccd8e4 1px solid; = MARGIN-RIGHT: 15px; BORDER-RIGHT: #ccd8e4 1px solid; PADDING-TOP: 5px } .nihms-highlight { TEXT-ALIGN: center; MARGIN: 0px 0.2em 0px 0px; WIDTH: 4em; BACKGROUND: = yellow; FLOAT: left; COLOR: #990000; FONT-SIZE: 0.8em; FONT-WEIGHT: bold } .retraction-notice { COLOR: red; FONT-SIZE: 1.2em; FONT-WEIGHT: bold } .retraction-notice A { COLOR: red } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TR[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TD[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TABLE.rendered TD { PADDING-BOTTOM: 0.2em; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0.2em } TABLE.rendered TH { PADDING-BOTTOM: 0.2em; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 0.2em } TABLE.rendered TD { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'top'] { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'middle'] { VERTICAL-ALIGN: middle } TABLE.rendered TD[valign=3D'bottom'] { VERTICAL-ALIGN: bottom } .head1 { FONT-SIZE: 120% } .head2 { FONT-SIZE: 110% } .head3 { FONT-SIZE: 105% } .head4 { FONT-SIZE: 99% } .head5 { FONT-SIZE: 90% } .acknowledgment-journal-title { FONT-STYLE: italic } DIV.exception-box { BORDER-BOTTOM: silver 1px dashed; BORDER-LEFT: silver 1px dashed; = PADDING-BOTTOM: 0.3em; PADDING-LEFT: 0.3em; PADDING-RIGHT: 0.3em; = MARGIN-BOTTOM: 1.31em; FONT-SIZE: 0.87em; BORDER-TOP: silver 1px dashed; = BORDER-RIGHT: silver 1px dashed; PADDING-TOP: 0.3em } DIV.exception-box .front-matter-section { FONT-SIZE: 1.14em } DIV.p { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.sec-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em } DIV.p-first { MARGIN-TOP: 0px } DIV.sec-first { MARGIN-TOP: 0px } DIV.p-last { MARGIN-BOTTOM: 0px } DIV.sec-last { MARGIN-BOTTOM: 0px } DIV.p-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } DIV.sec-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } SUP { LINE-HEIGHT: 0.8em; WHITE-SPACE: nowrap; FONT-SIZE: 0.8em } SUB { LINE-HEIGHT: 0.8em; WHITE-SPACE: nowrap; FONT-SIZE: 0.8em } .footnote-char { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-ec { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.3em } ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbase1.css BODY { BACKGROUND-COLOR: #f8f8f8 } .small-caps { FONT-VARIANT: small-caps; FONT-SIZE: 80% } .monospace { FONT-FAMILY: monospace } .pmctop-bg { BACKGROUND-COLOR: #fffeee } A.pmctop { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 12px; = TEXT-DECORATION: none } .pmc-body A:active { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-table A:active { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-table A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-figure A:active { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body-figure A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body A:hover { COLOR: #0080ff; TEXT-DECORATION: underline } .pmc-body A:hover { BACKGROUND-COLOR: #ccd8e4 } .pmc-body-table A:hover { BACKGROUND-COLOR: #ccd8e4 } .pmc-body-figure A:hover { BACKGROUND-COLOR: #ccd8e4 } HR { COLOR: #0072a8 } .base-highlight1 { BACKGROUND-COLOR: #ebebeb } .base-highlight2 { BACKGROUND-COLOR: #cccccc } .controls { FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: #000000; FONT-SIZE: = 75%; FONT-WEIGHT: bold; TEXT-DECORATION: none } .formtext { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80% } .link { COLOR: #0055aa; TEXT-DECORATION: none } .footer-link { TEXT-ALIGN: center; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80% } .side-head { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 90%; FONT-WEIGHT: bold } .side-subhead { MARGIN-TOP: 10px; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75%; = FONT-WEIGHT: bold } .side-item { BORDER-BOTTOM: #c0c0c0 1px solid; PADDING-BOTTOM: 2px; MARGIN: 2px 1px = 2px 4px; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .side-curr-item { BORDER-BOTTOM: #c0c0c0 1px solid; PADDING-BOTTOM: 2px; MARGIN: 2px 1px = 2px 4px; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .side-item A { COLOR: #0055aa; TEXT-DECORATION: none } .side-curr-item { COLOR: #808080 } .toc-header-vid { LINE-HEIGHT: 1.1em; MARGIN-TOP: 1.1em; FONT-FAMILY: Arial, sans-serif; = MARGIN-BOTTOM: 1.1em; FONT-SIZE: 120%; FONT-WEIGHT: bold } .more-iss-text { MARGIN-TOP: 1.35em; FONT-FAMILY: Arial, sans-serif; MARGIN-BOTTOM: = 1.35em; FONT-WEIGHT: bold } .more-iss-link { COLOR: #0055aa; TEXT-DECORATION: none } .arc-issue { TEXT-ALIGN: center; FONT-FAMILY: Arial, sans-serif; COLOR: #004080; = FONT-SIZE: 80%; TEXT-DECORATION: none } .toc-entry { LINE-HEIGHT: 1.12em } .toc-comment { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 70% } .toc-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .toc-author { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-cit-jour { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif; COLOR: #666666; = FONT-SIZE: 75% } .toc-cit-vol { FONT-FAMILY: Arial, sans-serif; COLOR: #666666; FONT-SIZE: 75% } .toc-cit-page { FONT-FAMILY: Arial, sans-serif; COLOR: #666666; FONT-SIZE: 75%; = FONT-WEIGHT: bold } .toc-cit-date { FONT-FAMILY: Arial, sans-serif; WHITE-SPACE: nowrap; COLOR: #666666; = FONT-SIZE: 75% } .toc-pmcid { FONT-FAMILY: Arial, sans-serif; WHITE-SPACE: nowrap; COLOR: #666666; = FONT-SIZE: 75% } .toc-link { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .toc-divider { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75%; TEXT-DECORATION: none } .toc-corrected-citation { MARGIN-LEFT: 1em } .toc-corrected-prefix { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-1st-author-etal { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-citation-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-prefix { FONT-WEIGHT: 600 } .toc-corrected-citation-info { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .toc-corrected-citation-info .citation-abbreviation { FONT-STYLE: italic } .toc-entry-abstract-toc { PADDING-BOTTOM: 0px; PADDING-LEFT: 2em; PADDING-RIGHT: 2em; = FONT-FAMILY: Arial, san-serif; COLOR: #333; FONT-SIZE: 75%; PADDING-TOP: = 0px } .cited-article-fm { BORDER-BOTTOM: 1px solid; BORDER-LEFT: 1px solid; BACKGROUND-COLOR: = #ebebeb; PADDING-LEFT: 8px; PADDING-RIGHT: 8px; MARGIN-LEFT: 0px; = BORDER-TOP: 1px solid; BORDER-RIGHT: 1px solid } .citing-article-fm { PADDING-LEFT: 8px; PADDING-RIGHT: 8px; MARGIN-LEFT: 0px } .sidefm-pmchead { FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: #0055aa; FONT-SIZE: = 85%; FONT-WEIGHT: bold; TEXT-DECORATION: none } .sidefm-pmhead { FONT-FAMILY: Verdana, Arial, sans-serif; COLOR: #0055aa; FONT-SIZE: = 85%; FONT-WEIGHT: bold; TEXT-DECORATION: none } .sidefm-pmsubhead { MARGIN-TOP: 10px; FONT-FAMILY: Arial, sans-serif; COLOR: #000000; = FONT-SIZE: 75%; FONT-WEIGHT: bold } .sidefm-pmclink { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .sidefm-pmart { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .side-section { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .side-caption { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .figure-table-caption-in-article { FONT-FAMILY: Arial, sans-serif; COLOR: #004080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .figure-table-caption-in-article { LINE-HEIGHT: 1.5em; COLOR: #000000 } .sidefm-pmclink-item { PADDING-LEFT: 10px } .sidefm-pmclink-item A { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmccurrent-item A { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmclink-item A:hover { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmccurrent-item A:hover { BORDER-BOTTOM: #c0c0c0 1px dotted; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; PADDING-LEFT: 5px; DISPLAY: block; TEXT-DECORATION: none } .sidefm-pmclink-item A { COLOR: #004080 } .sidefm-pmclink-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A { COLOR: #808080; CURSOR: default } .sidefm-pmccurrent-item A:hover { COLOR: #808080; CURSOR: default } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #dcdcdc } .side-section-curr { FONT-FAMILY: Arial, sans-serif; COLOR: #808080; FONT-SIZE: 75%; = TEXT-DECORATION: none } .sidebar-cell .sidefm-supplink { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .sidebar-cell .side-supplink { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } A.sidefm-supplink { COLOR: #b55a00; TEXT-DECORATION: none } A.side-supplink { COLOR: #b55a00; TEXT-DECORATION: none } .side-section-group { LINE-HEIGHT: 100%; PADDING-LEFT: 3px; PADDING-RIGHT: 3px; BORDER-TOP: = #0077aa 1px solid; TEXT-DECORATION: none } .head-separate { MARGIN-BOTTOM: 1.2em } .links-box { BORDER-BOTTOM: #666699 1px solid; BORDER-LEFT: #666699 1px solid; = PADDING-BOTTOM: 5px; MARGIN: 1.5em 15px 1.5em 10px; PADDING-LEFT: 5px; = PADDING-RIGHT: 5px; BORDER-TOP: #ccd8e4 1px solid; BORDER-RIGHT: #ccd8e4 = 1px solid; PADDING-TOP: 5px } :unknown { BORDER-BOTTOM: #336699 1px dotted; BORDER-LEFT: #336699 1px dotted; = BORDER-TOP: #336699 1px dotted; BORDER-RIGHT: #336699 1px dotted } .main-table-content { MARGIN-LEFT: 9px } .main-figure-content { MARGIN-LEFT: 9px } .fm-copyright { MARGIN-TOP: 16px; MARGIN-BOTTOM: 16px } .fm-author { MARGIN-TOP: 16px; MARGIN-BOTTOM: 16px } .fm-affl { MARGIN-TOP: 16px; MARGIN-BOTTOM: 12px; FONT-WEIGHT: normal } .fm-footnote { MARGIN-TOP: 12px; MARGIN-BOTTOM: 12px } .fm-pubdate { MARGIN-TOP: 12px; MARGIN-BOTTOM: 12px } .fm-citation { MARGIN-TOP: 0px } .fm-citation-ids { TEXT-ALIGN: right; PADDING-LEFT: 1em; FONT-FAMILY: Arial,sans-serif; = WHITE-SPACE: nowrap; FONT-SIZE: 85% } .fm-citation-ids-label { COLOR: #666 } .fm-citation-pmcid { =09 } .fm-citation-manuscriptid { =09 } .fm-copyright { MARGIN-TOP: 6px } .links-box .fm-footnote { MARGIN: 0px } .tocentry { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-LEFT: 2.5em } .toc-entry-alt-lang-msg { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .portal-tocentry { MARGIN-TOP: 1.6ex; MARGIN-BOTTOM: 2ex; MARGIN-RIGHT: 1em } .button-elsevierwt { BORDER-RIGHT-WIDTH: 0px; BORDER-TOP-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-LEFT-WIDTH: 0px } .elsevierwt-sponsored-label { COLOR: #f8f8f8; FONT-WEIGHT: 600 } .banner-journal-publisher-over-image-elsevierwt { POSITION: relative; LINE-HEIGHT: 1.5em; FONT-FAMILY: Georgia, "Times = New Roman", Times, serif; HEIGHT: 75px; COLOR: #9a7947; MARGIN-LEFT: = 20px; OVERFLOW: hidden; TOP: -30px; MARGIN-RIGHT: 145px } .banner-journal-name-elsevierwt { COLOR: #954a4a; MARGIN-LEFT: 1em; FONT-SIZE: 1.2em; FONT-WEIGHT: 600 } A.elsevierwt-button-link { POSITION: relative; TOP: 40px; LEFT: 360px } A.elsevierwt-button-link:hover { BACKGROUND-COLOR: #f1e8ce } .fm-elsevierwt-disclaimer { MARGIN-TOP: 12px; FONT-FAMILY: Arial, sans-serif; MARGIN-BOTTOM: 12px; = FONT-SIZE: 0.68em } .ref-cit-blk { LINE-HEIGHT: 1.4em; MARGIN-TOP: 1.4em } .back-ref-list-1st-line-shifted LI { LINE-HEIGHT: 1.4em; MARGIN-TOP: 1.4em } .back-ref-list LI { LINE-HEIGHT: 1.4em; MARGIN-TOP: 1.4em } DIV.ref-label { BORDER-BOTTOM: #f8f8f8 1px solid; TEXT-ALIGN: right; BORDER-LEFT: = #f8f8f8 1px solid; WIDTH: 45px; FLOAT: left; BORDER-TOP: #f8f8f8 1px = solid; BORDER-RIGHT: #f8f8f8 1px solid } DIV.ref-cit { MARGIN-LEFT: 55px } SPAN.ref-label { FONT-STYLE: italic } SPAN.ref-cit { =09 } .back-ref-list-1st-line-shifted LI { LIST-STYLE-TYPE: none; TEXT-INDENT: -1.5em; PADDING-LEFT: 1.5em; = MARGIN-LEFT: 2em } .array-table { LINE-HEIGHT: 1.31em; BACKGROUND-COLOR: #f4f4f4; MARGIN-TOP: 1em; WIDTH: = 100%; MARGIN-BOTTOM: 1em } .array-table-inline { LINE-HEIGHT: 1.31em; BACKGROUND-COLOR: #f4f4f4; MARGIN-TOP: 1em; WIDTH: = 100%; MARGIN-BOTTOM: 1em } .array-table TD { PADDING-BOTTOM: 0em; PADDING-LEFT: 0.5em; PADDING-RIGHT: 0.5em; = PADDING-TOP: 0em } .array-table-inline { DISPLAY: inline } .list-item-w-pw { BORDER-BOTTOM: #f8f8f8 1px solid; BORDER-LEFT: #f8f8f8 1px solid; = BORDER-TOP: #f8f8f8 1px solid; BORDER-RIGHT: #f8f8f8 1px solid } .list-item-w-pw-prefix-word { POSITION: relative; TEXT-ALIGN: right; DISPLAY: inline-block } .list-item-w-pw-content { POSITION: relative; TOP: -1.35em } .list-item-p-question { FONT-WEIGHT: bold } SPAN.underline { BORDER-BOTTOM: black 1px solid } SPAN.double-underline { BORDER-BOTTOM: black 3px double } SPAN.bold-double-underline { BORDER-BOTTOM: black 3px double } .verse-group { LINE-HEIGHT: 1.16em; MARGIN: 1.31em 2em; FONT-FAMILY: "Monotype = Corsiva", "Apple Chancery", "URW Chancery L", cursive; FONT-SIZE: 1.12em } .internal-control { PADDING-BOTTOM: 0.5em; BACKGROUND-COLOR: #f0f0f0; MARGIN: 1.5em auto; = PADDING-LEFT: 0.5em; WIDTH: 95%; PADDING-RIGHT: 0.5em; FONT-WEIGHT: = bold; PADDING-TOP: 0.5em } .sidebar-menu-square-image-holder { PADDING-RIGHT: 0.35em; VERTICAL-ALIGN: middle; _padding-top: 0.35em } DIV.figure-role { MARGIN: 1em 0px } DIV.signature { MARGIN: 1.8em 0px; FONT-FAMILY: "Monotype Corsiva", "Apple Chancery", = "URW Chancery L", cursive } DIV.simple-list-item-w-label { TEXT-INDENT: -2em; FLOAT: left } .selective-deposit-msg { BORDER-BOTTOM: #f4f4f4 0.5em solid; BORDER-LEFT: #f4f4f4 0.5em solid; = BACKGROUND-COLOR: #f4f4f4; FONT-FAMILY: Arial,sans-serif; FONT-SIZE: = 80%; BORDER-TOP: #f4f4f4 0.5em solid; BORDER-RIGHT: #f4f4f4 0.5em solid } .fm-title { MARGIN-TOP: 16px } .fm-trans-title { MARGIN-TOP: 16px } .ukpmc-tocentry-icon { BORDER-RIGHT-WIDTH: 0px; BORDER-TOP-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: text-bottom; BORDER-LEFT-WIDTH: 0px; MARGIN-RIGHT: = 0.25em } .i18n-debug { BACKGROUND-COLOR: #fff0df } .i18n-debug * { BACKGROUND-COLOR: #fff0df } .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffe2bf } .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffe2bf } .i18n-debug .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffd39f } .i18n-debug .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffd39f } .i18n-debug .i18n-debug .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffc47f } .i18n-debug .i18n-debug .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffc47f } A.i18n-switcher { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 0.75em; FONT-WEIGHT: normal; = TEXT-DECORATION: none } A.i18n-switcher:hover { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 0.75em; FONT-WEIGHT: normal; = TEXT-DECORATION: none } A.i18n-switcher-current { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 0.75em; FONT-WEIGHT: bold; = TEXT-DECORATION: none } A.i18n-switcher-current:hover { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 0.75em; FONT-WEIGHT: bold; = TEXT-DECORATION: none } IMG.i18n-switcher { BORDER-BOTTOM-STYLE: none; BORDER-RIGHT-STYLE: none; WIDTH: 11px; = BORDER-TOP-STYLE: none; HEIGHT: 8px; VERTICAL-ALIGN: super; = BORDER-LEFT-STYLE: none; MARGIN-RIGHT: 2px } ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbars-slateblue.css .doc-group1 { BACKGROUND-COLOR: #0072a8; FONT-FAMILY: Verdana, sans-serif; COLOR: = white; FONT-SIZE: 110%; FONT-WEIGHT: bold } .doc-group2 { TEXT-ALIGN: center; BACKGROUND-COLOR: #cccccc; FONT-FAMILY: Arial, = sans-serif; COLOR: #004080; FONT-WEIGHT: bold } .doc-group3 { TEXT-ALIGN: center; BACKGROUND-COLOR: #cccccc; FONT-FAMILY: Arial, = sans-serif; COLOR: #000000; FONT-WEIGHT: bold } .doc-group4 { =09 } .toc-supp-link { FONT-FAMILY: Arial, sans-serif; COLOR: #e64a00; FONT-SIZE: 75%; = TEXT-DECORATION: none } .toc-highlight1 { BACKGROUND-COLOR: #ffffd0 } .toc-highlight2 { BACKGROUND-COLOR: #ace4ff } .head1 { BORDER-BOTTOM: #0072a8 1pt solid; TEXT-ALIGN: center; BORDER-LEFT: = #0072a8 1pt solid; BACKGROUND-COLOR: #0072a8; FONT-FAMILY: Verdana, = sans-serif; COLOR: white; FONT-SIZE: 110%; BORDER-TOP: #0072a8 1pt = solid; FONT-WEIGHT: bold; BORDER-RIGHT: #0072a8 1pt solid } .head1A { BACKGROUND-COLOR: #cccccc; FONT-FAMILY: Arial, sans-serif; COLOR: = #004080; FONT-WEIGHT: bold } .append-head1 { TEXT-ALIGN: center; FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .colorbar-link { COLOR: #ffffff } .head1 A:link { COLOR: white } .head1 A:visited { COLOR: white } .head1A A:link { COLOR: white } .head1A A:visited { COLOR: white } ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcbody4.css .fm-vol-iss-date { TEXT-ALIGN: left; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-citation { TEXT-ALIGN: left; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-citation-ids { FONT-SIZE: 75% } .fm-citation .fm-vol-iss-date { FONT-SIZE: 100% } .pubnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75%; FONT-WEIGHT: bold } .pubnote-hilite { BACKGROUND-COLOR: #ebebeb; FONT-FAMILY: Arial, sans-serif; FONT-SIZE: = 75% } .fm-dochead { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .fm-doctopic { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-docsubject { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-ser-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .fm-supp-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 80%; FONT-WEIGHT: bold } .fm-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 125%; FONT-WEIGHT: bold } .fm-subtitle { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .fm-trans-title { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 120% } .fm-trans-subtitle { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 105% } .fm-author { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 110% } .fm-affl { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-pubdate { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-editor { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-footnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .fm-author .fm-footnote { FONT-SIZE: 68.5% } .fm-author .fm-affl { FONT-SIZE: 68.5% } .fm-author .fm-footnote .fm-affl { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 100% } .fm-editor .fm-footnote .fm-affl { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 100% } .fm-editor .fm-footnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 100% } .fm-role { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif } .fm-copyright { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .pmcnote { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 85% } .abs-head2 { =09 } .abs-head2 { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .kwd-label { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .abs-head3 { FONT-FAMILY: Arial, sans-serif } .head2 { FONT-FAMILY: Arial, sans-serif; FONT-WEIGHT: bold } .head3 { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif } .head4 { FONT-FAMILY: Arial, sans-serif } .head5 { =09 } .kwd-text { FONT-SIZE: 85% } .eqn-image { TEXT-ALIGN: center } .eqn-id { TEXT-ALIGN: right; FONT-WEIGHT: bold } .box { BORDER-BOTTOM: #607080 1px solid; BORDER-LEFT: #607080 1px solid; = BACKGROUND-COLOR: #e4e8ec; OVERFLOW: auto; BORDER-TOP: #607080 1px = solid; BORDER-RIGHT: #607080 1px solid } .boxhead1 { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 105%; FONT-WEIGHT: bold } .boxhead2 { FONT-WEIGHT: bold } A.cite-reflink { COLOR: #0050a0 } .fig-table-link { COLOR: #0050a0 } A.int-reflink { COLOR: #0050a0 } A.ext-reflink { COLOR: #0050a0 } .figwind-cite { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .figwind-copyrt { FONT-FAMILY: Arial, sans-serif; FONT-SIZE: 75% } .product-source { FONT-STYLE: italic } .signature-group { FONT-STYLE: italic; MARGIN-LEFT: 2em; FONT-WEIGHT: bold } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/css/pmcrefs5.css .ref-id { } .ref-title { } .ref-author { } .ref-journal { } .ref-pubdate { } .ref-vol { } .ref-iss { } .ref-page { } .ref-edition { } .ref-editor { } .ref-pubname { } .ref-publoc { } .ref-extlink { COLOR: #0050a0 } ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/jsutils/css/tileshop_pmc.1/tileshop_pmc.1.css .viewport { -moz-user-select: none; -khtml-user-select: none; user-select: none } .viewport-static-image { -moz-user-select: none; -khtml-user-select: none; user-select: none } .panorama { -moz-user-select: none; -khtml-user-select: none; user-select: none } .scale-pmc { -moz-user-select: none; -khtml-user-select: none; user-select: none } .viewport { FLOAT: left } .viewport-static-image { FLOAT: left } .viewport { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif); = OVERFLOW: hidden } .viewport .dnd { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif) } .dnd { MARGIN-LEFT: auto; CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/grab.cur), move; = MARGIN-RIGHT: auto } .moving { CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/grabbing.cur), move } .viewport-static-image { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc; OVERFLOW: hidden } .viewport-static-image IMG { CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/zoomin.cur), auto } .tileshop { BACKGROUND-COLOR: #fff; FLOAT: left; CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/zoomin.cur), auto } .nodrag { CURSOR: default } .static { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc; CURSOR: default } .static IMG { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc; CURSOR: default } .half-static { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc } .half-static IMG { BACKGROUND-IMAGE: none; BACKGROUND-COLOR: #ccc } .tile-fill { BACKGROUND-COLOR: #f0f } .panorama { BORDER-BOTTOM-STYLE: none; BORDER-LEFT: black 1px solid; = BACKGROUND-COLOR: #ecf0f4; BORDER-TOP: black 1px solid; BORDER-RIGHT: = #f0ffff 3px solid } .panorama DIV { OVERFLOW: hidden } .panorama IMG { CURSOR: pointer } .pan-switcher { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/pan_close.gif); = BORDER-BOTTOM: #000 1px solid; BORDER-LEFT: #000 1px solid; = BACKGROUND-COLOR: #fff; WIDTH: 10px; BACKGROUND-REPEAT: no-repeat; = HEIGHT: 10px; BORDER-TOP: #000 1px solid; CURSOR: pointer; BORDER-RIGHT: = #000 1px solid; _background-color: transparent; _border: none } .pan-switcher-close { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/pan_open.gif) } .pan { BORDER-BOTTOM: #000 2px dotted; FILTER: alpha(opacity=3D70); = BORDER-LEFT: #000 2px dotted; BACKGROUND-COLOR: #dce0e4; FONT-SIZE: 1px; = BORDER-TOP: #000 2px dotted; CURSOR: move; BORDER-RIGHT: #000 2px = dotted; opacity: 0.7 } DIV.panel { BORDER-BOTTOM: gray 1px solid; BORDER-LEFT: gray 1px solid; = PADDING-BOTTOM: 0px; BACKGROUND-COLOR: #ecf0f4; MARGIN: 0px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: left; BORDER-TOP: gray 1px = solid; BORDER-RIGHT: gray 1px solid; PADDING-TOP: 0px } DIV.panel P { TEXT-ALIGN: center; PADDING-BOTTOM: 0.2em; BACKGROUND-COLOR: #ecf0f4; = MARGIN: 0px; MIN-HEIGHT: 21px; PADDING-LEFT: 0px; WIDTH: 100%; = PADDING-RIGHT: 0px; FLOAT: left; PADDING-TOP: 0.1em } DIV.panel P SPAN { MARGIN: 0px; PADDING-LEFT: 25px; WIDTH: 85%; FLOAT: left } DIV.panel P A { MIN-HEIGHT: 21px; DISPLAY: none; TEXT-DECORATION: none } DIV.panel P A.active { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/toolbar.png); MARGIN: = 0px 9px 0px 0px; WIDTH: 36px; DISPLAY: block; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 13px 0px; FLOAT: right; HEIGHT: 21px; = _background-image: url(../../img/tileshop_pmc.1/toolbar.gif); = _margin-right: 5px } DIV.panel P A.active:hover { BACKGROUND-COLOR: #ecf0f4; BACKGROUND-REPEAT: no-repeat; = BACKGROUND-POSITION: -67px 0px; TEXT-DECORATION: none } DIV.panel DL { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DD { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DT { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DT IMG { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } DIV.panel DL { WIDTH: 100%; FLOAT: left } DIV.panel DL DD { FLOAT: right } DIV.panel DL DT { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/loading_bg.gif); FLOAT: = left } .scale-pmc { MARGIN: auto; WIDTH: 32px; PADDING-TOP: 0em } .scale-pmc A { BACKGROUND-IMAGE: url(../../img/tileshop_pmc.1/toolbar.png); = PADDING-BOTTOM: 1px; MARGIN: 0px; PADDING-LEFT: 1px; PADDING-RIGHT: 1px; = DISPLAY: block; BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; FONT-SIZE: = 3px; TEXT-DECORATION: none; PADDING-TOP: 1px; _background-image: = url(../../img/tileshop_pmc.1/toolbar.gif) } .scale-pmc A:hover { BACKGROUND-COLOR: transparent; BACKGROUND-REPEAT: no-repeat; = TEXT-DECORATION: none } .scale-pmc A.scale-up { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-up-disabled { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-down-disabled { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-down { MARGIN: 2px auto; WIDTH: 22px; HEIGHT: 22px } .scale-pmc A.scale-up { BACKGROUND-POSITION: 4px -26px } .scale-pmc A.scale-up:hover { BACKGROUND-POSITION: -76px -26px } .scale-pmc A.scale-up-disabled { BACKGROUND-POSITION: -36px -26px; CURSOR: default } .scale-pmc A.scale-down { BACKGROUND-POSITION: 4px -226px } .scale-pmc A.scale-down:hover { BACKGROUND-POSITION: -76px -226px } .scale-pmc A.scale-down-disabled { BACKGROUND-POSITION: -36px -226px; CURSOR: default } .scale-pmc A.scale-1 { BACKGROUND-POSITION: 3px -57px } .scale-pmc A.scale-1:hover { BACKGROUND-POSITION: -77px -57px } .scale-pmc A.selected-1 { BACKGROUND-POSITION: -37px -57px; CURSOR: default } .scale-pmc A.selected-1:hover { BACKGROUND-POSITION: -37px -57px; CURSOR: default } .scale-pmc A.scale-2 { BACKGROUND-POSITION: 3px -77px } .scale-pmc A.scale-2:hover { BACKGROUND-POSITION: -77px -77px } .scale-pmc A.selected-2 { BACKGROUND-POSITION: -37px -77px; CURSOR: default } .scale-pmc A.selected-2:hover { BACKGROUND-POSITION: -37px -77px; CURSOR: default } .scale-pmc A.scale-3 { BACKGROUND-POSITION: 3px -97px } .scale-pmc A.scale-3:hover { BACKGROUND-POSITION: -77px -97px } .scale-pmc A.selected-3 { BACKGROUND-POSITION: -37px -97px; CURSOR: default } .scale-pmc A.selected-3:hover { BACKGROUND-POSITION: -37px -97px; CURSOR: default } .scale-pmc A.scale-4 { BACKGROUND-POSITION: 3px -117px } .scale-pmc A.scale-4:hover { BACKGROUND-POSITION: -77px -117px } .scale-pmc A.selected-4 { BACKGROUND-POSITION: -37px -117px; CURSOR: default } .scale-pmc A.selected-4:hover { BACKGROUND-POSITION: -37px -117px; CURSOR: default } .scale-pmc A.scale-5 { BACKGROUND-POSITION: 3px -137px } .scale-pmc A.scale-5:hover { BACKGROUND-POSITION: -77px -137px } .scale-pmc A.selected-5 { BACKGROUND-POSITION: -37px -137px; CURSOR: default } .scale-pmc A.selected-5:hover { BACKGROUND-POSITION: -37px -137px; CURSOR: default } .scale-pmc A.scale-6 { BACKGROUND-POSITION: 3px -157px } .scale-pmc A.scale-6:hover { BACKGROUND-POSITION: -77px -157px } .scale-pmc A.selected-6 { BACKGROUND-POSITION: -37px -157px; CURSOR: default } .scale-pmc A.selected-6:hover { BACKGROUND-POSITION: -37px -157px; CURSOR: default } .scale-pmc A.scale-7 { BACKGROUND-POSITION: 3px -177px } .scale-pmc A.scale-7:hover { BACKGROUND-POSITION: -77px -177px } .scale-pmc A.selected-7 { BACKGROUND-POSITION: -37px -177px; CURSOR: default } .scale-pmc A.selected-7:hover { BACKGROUND-POSITION: -37px -177px; CURSOR: default } .scale-pmc A.scale-8 { BACKGROUND-POSITION: 3px -207px } .scale-pmc A.scale-8:hover { BACKGROUND-POSITION: -77px -207px } .scale-pmc A.selected-8 { BACKGROUND-POSITION: -37px -207px; CURSOR: default } .scale-pmc A.selected-8:hover { BACKGROUND-POSITION: -37px -207px; CURSOR: default } ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pubmedcentral.nih.gov/corehtml/pmc/js/common.js // Called from many places to handle links.=0A= // Params:=0A= // link: URL. 'this' to reuse same window, else ""=0A= // windowname: Reference name for window=0A= // additional: Attributes for window.open, from:=0A= // width, height, resizable, scrollbars, toolbar, location, = directories,=0A= // status, menubar, copyhistory.=0A= // Notes: Book version always provides menubar, toolbar, etc.=0A= //=0A= function startTargetBook(link,windowname,width,height,additional)=0A= {=0A= startTarget(link,windowname,width,height,additional)=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function startTarget(link,windowname,width,height, additional)=0A= {=0A= if(! window.focus)=0A= return;=0A= =0A= var sizestring =3D ",width=3D" + width + ",height=3D" + height;=0A= var opt =3D = "menubar=3Dno,toolbar=3Dno,status=3Dno,scrollbars=3Dyes,resizable=3Dyes,d= ependent=3Dyes,location=3Dno";=0A= var allOptions =3D opt + sizestring;=0A= if (additional) { allOptions =3D allOptions + ',' + additional; }=0A= =0A= windowname =3D String(windowname).replace(/-/g, "_")=0A= var moveToXDefault =3D 75=0A= var moveToYDefault =3D 50=0A= =0A= var moveToX =3D moveToXDefault=0A= var moveToY =3D moveToYDefault=0A= var yAdj =3D 50=0A= var yAdjDelta =3D 25=0A= =0A= var barNames =3D ['menubar', 'toolbar', 'statusbar']=0A= for (var idx in barNames)=0A= { =0A= if (String(allOptions).lastIndexOf(barNames[idx] + '=3Dyes') > =0A= String(allOptions).lastIndexOf(barNames[idx] + '=3Dno'))=0A= yAdj +=3D yAdjDelta=0A= }=0A= =0A= try {=0A= if (window.screen.width && width > 0)=0A= moveToX =3D Math.ceil((window.screen.width - width)) - 15=0A= moveToX =3D (moveToX > 0 ? moveToX : moveToXDefault)=0A= =0A= if (window.screen.height && height > 0)=0A= moveToY =3D Math.ceil((window.screen.height - height)) - yAdj=0A= moveToY =3D (moveToY > 0 ? moveToY : moveToYDefault)=0A= }=0A= catch (e) {}=0A= =0A= var wLeftTopCornerOptions =3D ',left=3D' + moveToX + ',top=3D' + = moveToY + ',screenX=3D' + moveToX + ',screenY=3D' + moveToY=0A= =0A= allOptions =3D allOptions + wLeftTopCornerOptions=0A= =0A= w =3D window.open ("", windowname, allOptions)=0A= w.focus()=0A= =0A= link.target=3Dwindowname=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function focuswin(windowname)=0A= {=0A= windowname =3D String(windowname).replace(/-/g, "_")=0A= w =3D = window.open("",windowname,"menubar=3Dyes,scrollbars=3Dyes,toolbar=3Dyes,l= ocation=3Dyes,status=3Dyes,directories=3Dyes,resizable=3Dyes");=0A= w.focus();=0A= =0A= return true;=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function reverseString (inStr)=0A= {=0A= var outStr =3D ''=0A= =0A= for (i =3D0; i <=3D inStr.length; i++)=0A= {=0A= outStr =3D inStr.charAt(i) + outStr=0A= }=0A= =0A= return outStr=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function reverseAndReplaceString (inStr, findStr, newStr)=0A= {=0A= return reverseString(inStr).replace(findStr, newStr)=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function initUnObscureEmail (className, innerHTML)=0A= {=0A= =0A= try{=0A= if (window.addEventListener)=0A= window.addEventListener('load', function() {unObscureEmail = (className, innerHTML)}, false)=0A= else if (window.attachEvent)=0A= window.attachEvent('onload', function() {unObscureEmail = (className, innerHTML)})=0A= }catch(e){=0A= }=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function unObscureEmail (className, innerHTML)=0A= {=0A= try {=0A= if (typeof(unObscuredEmails) =3D=3D 'undefined')=0A= unObscuredEmails =3D new Array()=0A= =0A= if (! unObscuredEmails[className])=0A= {=0A= =0A= var elmnts =3D document.getElementsByTagName("span")=0A= for (var i =3D 0, len =3D elmnts.length; i < len; i++)=0A= {=0A= if (elmnts.item(i).className.indexOf(className, " ") = !=3D -1)=0A= {=0A= elmnts.item(i).innerHTML =3D innerHTML;=0A= unObscuredEmails[className] =3D true=0A= =0A= }=0A= }=0A= }=0A= }=0A= catch(e){=0A= }=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function pubMedDbLinkSubmit(control) {=0A= try{=0A= if (control.pubmedOption)=0A= control =3D control.pubmedOption=0A= if (control.options)=0A= location.href =3D = control.options[control.options.selectedIndex].value;=0A= }=0A= catch(e){}=0A= return false;=0A= }=0A= ------=_NextPart_000_0000_01C99C34.5260FC50 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/jsutils/utils.1.js // = /web/private/htdocs/staff/sponomar/TEST/corehtml/jsutils/utils.1.js.orig=0A= =0A= var = utils=3D{KeyCode_TAB:9,KeyCode_DELETE:46,KeyCode_BACKSPACE:8,KeyCode_LEFT= _ARROW:37,KeyCode_RIGHT_ARROW:39,KeyCode_HOME:36,KeyCode_END:35,KeyCode_P= AGE_UP:33,KeyCode_PAGE_DOWN:34,KeyCode_UP_ARROW:38,KeyCode_DOWN_ARROW:40,= KeyCode_ESC:27,KeyCode_ENTER:13,KeyCode_SPACE:32,KeyCode_SHIFT_KEY:16,Key= Code_CTRL_KEY:17,KeyCode_ALT_KEY:18,KeyCode_LEFT_MS_WINDOWS_KEY:91,KeyCod= e_RIGHT_MS_WINDOWS_KEY:92,KeyCode_MS_MENU_KEY:93,bIsIe:0/*@cc_on+1@*/,isO= bject:function(a){return(a&&typeof = a=3D=3D'object');},isArray:function(a){return = this.isObject(a)&&a.constructor=3D=3DArray;},getParent:function(obj){if(o= bj){var = result=3Dobj.parentNode;while(result&&result.nodeType!=3D1)result=3Dresul= t.nextSibling;if(result)return result;}=0A= return null;},getFirstChild:function(obj){if(obj){var = result=3Dobj.firstChild;while(result&&result.nodeType!=3D1)result=3Dresul= t.nextSibling;if(result)return result;}=0A= return null;},getNextSibling:function(obj,tagName){if(obj){var = result=3Dobj.nextSibling;if(tagName){var = tn=3DtagName.toUpperCase();while(result&&result.tagName!=3Dtn)result=3Dre= sult.nextSibling;}else{while(result&&result.nodeType!=3D1)result=3Dresult= .nextSibling;}=0A= return result;}=0A= return null;},getPreviousSibling:function(obj,tagName){if(obj){var = result=3Dobj.previousSibling;if(tagName){var = tn=3DtagName.toUpperCase();while(result&&result.tagName!=3Dtn)result=3Dre= sult.previousSibling;}else{while(result&&result.nodeType!=3D1)result=3Dre= sult.previousSibling;}=0A= return result;}=0A= return null;},nextItem:function(item,nodeName){if(item=3D=3Dnull)return = null;var = next=3Ditem.nextSibling;while(next!=3Dnull){if(next.nodeName=3D=3DnodeNam= e)return next;next=3Dnext.nextSibling;}=0A= return null;},previousItem:function(item,nodeName){var = previous=3Ditem.previousSibling;while(previous!=3Dnull){if(previous.nodeN= ame=3D=3DnodeName)return previous;previous=3Dprevious.previousSibling;}=0A= return null},moveBefore:function(item1,item2){var = parent=3Ditem1.parentNode;parent.removeChild(item1);parent.insertBefore(i= tem1,item2);},moveAfter:function(item1,item2){var = parent=3Ditem1.parentNode;parent.removeChild(item1);parent.insertBefore(i= tem1,item2?item2.nextSibling:null);},insertAfter:function(parent,node,ref= erenceNode){parent.insertBefore(node,referenceNode.nextSibling);},removeC= hildren:function(oObj){if(!oObj||typeof = oObj!=3D"object")return;while(oObj&&oObj.hasChildNodes()){this.removeAllC= hildren(oObj.firstChild);oObj.removeChild(oObj.firstChild);}},removeAllCh= ildren:function(oObj){this.removeChildren(oObj);},getTextContent:function= (x){/*@cc_on return x.text;@*/return = x.textContent;},createCookie:function(name,value,days,path){if(days){var = date=3Dnew Date();date.setTime(date.getTime()+(days*24*60*60*1000));var = expires=3D'; expires=3D'+date.toGMTString();}else = expires=3D'';document.cookie=3Dname+'=3D'+value+expires+'; = path=3D'+(path?path:"/");},readCookie:function(name){var = nameEQ=3Dname+'=3D';var ca=3Ddocument.cookie.split(';');for(var = i=3D0;itest2){dim.w=3DparseInt(x.scrol= lWidth);dim.h=3Dtest1;}else{dim.w=3DparseInt(x.offsetWidth);dim.h=3Dtest2= ;}=0A= return dim;},getStyle:function(oObj,styleProp){var = res;if(oObj.currentStyle){res=3DoObj.currentStyle[styleProp];}=0A= if(typeof(res)!=3D"string"){if(oObj.style){res=3DoObj.style[styleProp];}=0A= if(typeof(res)!=3D"string"){if(document.defaultView){res=3Ddocument.defau= ltView.getComputedStyle(oObj,null).getPropertyValue(styleProp);}=0A= if(typeof(res)!=3D"string"){return null;}}}=0A= return res;},drawText:function(sText,sId,add){if(!sId)sId=3D"debug";var = obj=3Ddocument.getElementById(sId);if(obj){if(add)=0A= obj.innerHTML=3D"
"+sText;else=0A= obj.innerHTML+=3DsText;}},selectRange:function(oObj,iStart,iLength){if(!(= oObj&&oObj.value))return;if(oObj.createTextRange){var = oRange=3DoObj.createTextRange();oRange.moveStart("character",iStart);oRan= ge.moveEnd("character",iLength-oObj.value.length);oRange.select();}else = if(oObj.setSelectionRange){oObj.setSelectionRange(iStart,iLength);}=0A= oObj.focus();},getSelection:function(){var = text=3D"";if(window.getSelection){text+=3Dwindow.getSelection();}else = if(document.getSelection){text+=3Ddocument.getSelection();}else = if(document.selection){text+=3Ddocument.selection.createRange().text;}=0A= return text;},getPlural:function = x_Plural(iN,sSuffix){if(undefined=3D=3DsSuffix){return(iN>1?"s":"");}else= = if("y"=3D=3DsSuffix){return(iN>1?"ies":"");}else{return(iN>1?sSuffix+"s":= sSuffix);}},getPeriodToString:function(iDelta){var x=3D"Error, cannot = convert '"+iDelta+"'";var = sDir;iDelta=3DparseInt(iDelta);if(iDelta<0){sDir=3D" = before";iDelta=3D-iDelta;}else=0A= sDir=3D" ago";var iS=3DparseInt(iDelta/1000);var = iM,iH,iD;if(iS<60){x=3DiS+" = second"+this.getPlural(iS);}else{iM=3DparseInt(iS/60);if(iM<60){x=3DiM+" = minute"+this.getPlural(iM);}else{iH=3DparseInt(iM/60);if(iH<24){iM=3DiM-i= H*60;x=3DiH+" hour"+this.getPlural(iH)+" and "+iM+" = minute"+this.getPlural(iM);}else{iD=3DparseInt(iH/24);iH-=3DiD*24;x=3DiD+= " day"+this.getPlural(iD)+" and "+iH+" hour"+this.getPlural(iH);}}}=0A= return x+sDir;},isEmail:function(s){var = filter=3D/^([\w-]+(?:\.[\w-]+)*)@((?:[\w-]+\.)*\w[\w-]{0,66})\.([a-z]{2,6= }(?:\.[a-z]{2})?)$/i;return(filter.test(s))},addEvent_guid:1,addEvent:fun= ction(element,type,handler){if(!handler.$$guid)handler.$$guid=3Dthis.addE= vent_guid++;if(!element.events)element.events=3D{};var = handlers=3Delement.events[type];if(!handlers){handlers=3Delement.events[t= ype]=3D{};if(element["on"+type]){handlers[0]=3Delement["on"+type];}}=0A= handlers[handler.$$guid]=3Dhandler;element["on"+type]=3DhandleEvent;funct= ion handleEvent(event){var = returnValue=3Dtrue;event=3Devent||fixEvent(window.event);var = handlers=3Dthis.events[event.type];for(var i in = handlers){this.$$handleEvent=3Dhandlers[i];if(this.$$handleEvent(event)=3D= =3D=3Dfalse){returnValue=3Dfalse;}}=0A= return returnValue;};function = fixEvent(event){event.preventDefault=3DfixEvent.preventDefault;event.stop= Propagation=3DfixEvent.stopPropagation;return = event;};fixEvent.preventDefault=3Dfunction(){this.returnValue=3Dfalse;};f= ixEvent.stopPropagation=3Dfunction(){this.cancelBubble=3Dtrue;};return = handler.$$guid;},removeEvent:function(element,type,handler){if(element.ev= ents&&element.events[type]){delete = element.events[type][handler.$$guid];return handler.$$guid;}=0A= return = null;},preventDefault:function(e){if(e.preventDefault)e.preventDefault();= else = window.event.returnValue=3Dfalse;},getRelatedTarget:function(e){if(!e)var= e=3Dwindow.event;if(e.relatedTarget)return e.relatedTarget;else = if(e.toElement)return e.toElement;else if(e.fromElement)return = e.fromElement;},getTargetObj:function(eEvent){var oTarget;var = e=3DeEvent||window.event;if(e=3D=3Dnull)return = null;if(e.srcElement=3D=3Dnull)oTarget=3De.target;else = oTarget=3De.srcElement;while(oTarget&&oTarget.nodeType!=3D1)oTarget=3DoTa= rget.parentNode;return oTarget;},printObj:function(oObj,iLevel){var = s=3D"";var sIdent=3D"";if(!iLevel)iLevel=3D0;for(var = i=3D0;i";}=0A= return s;},jsLoader:{oLoaded:[],sBase:"",load:function(aScripts){var = oS=3Ddocument.getElementsByTagName("script");for(var = j=3D0;j");this.oLoaded.push(sNewSrc);}}}},inse= rtInHtml:function(text,obj){if(document.all){obj.innerHTML+=3Dtext;}else{= var range=3Ddocument.createRange();range.setStartAfter(obj);var = docFrag=3Drange.createContextualFragment(text);obj.appendChild(docFrag);}= },replaceInHtml:function(text,obj){if(document.all){obj.innerHTML=3Dtext;= }else{while(obj.hasChildNodes())obj.removeChild(obj.firstChild);var = range=3Ddocument.createRange();range.setStartAfter(obj);var = docFrag=3Drange.createContextualFragment(text);obj.appendChild(docFrag);}= }};String.prototype.trimSpaces=3Dfunction(trimMode){var = targetString=3Dthis;var = iPos=3D0;if(!trimMode)trimMode=3D0;if(trimMode=3D=3D0||trimMode=3D=3D1){i= f(targetString.charAt(iPos)=3D=3D" = "){while(targetString.charAt(iPos)=3D=3D" = ")iPos++;targetString=3DtargetString.substr(iPos);}}=0A= iPos=3DtargetString.length-1;if(trimMode=3D=3D0||trimMode=3D=3D2){if(targ= etString.charAt(iPos)=3D=3D" "){while(targetString.charAt(iPos)=3D=3D" = ")iPos--;targetString=3DtargetString.substr(0,iPos+1);}}=0A= return targetString;}=0A= function $(){var elements=3Dnew Array();for(var = i=3D0;i0) {=0A= var W=3DoMetadata.aView[0].W * oThis.fScale;=0A= for = (oThis.iScaleIndex=3D0;oThis.iScaleIndex