From: Subject: ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target Date: Sat, 3 Apr 2010 18:53:51 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01CAD35F.003A3910" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817685/?tool=pubmed =EF=BB=BF ASPM-associated stem cell = proliferation is involved in malignant progression of gliomas and = constitutes an attractive therapeutic target
3D"BioMed
<= !-- something -->
","
Journal List > = Cancer Cell Int = >=20 v.10; 2010

Formats:

  • Abstract=20 |=20
  • Full Text |=20
  • PDF=20 (2.9M)
Cancer Cell Int. 2010; 10: 1.=20
Published online 2010 = January 11.=20 doi:=20 10.1186/1475-2867-10-1.
PMCID:=20 = PMC2817685
Copyright=20 =C2=A92010 Bikeye et al; licensee BioMed Central Ltd.
ASPM-associated stem cell proliferation is = involved in=20 malignant progression of gliomas and constitutes an attractive = therapeutic=20 target
Sandra-Nadia Ngwabyt=20 Bikeye,1 Carole Colin,2 Yannick = Marie,1=20 Rapha=C3=ABl Vampouille,4 Philippe = Ravassard,4 Audrey=20 Rousseau,5 Blandine Boisselier,1 Ahmed=20 Idbaih,1,3 Charles F=C3=A9lix = Calvo,1 Pascal=20 Leuraud,6 Myriam Lassalle,6 Soufiane El=20 Hallani,1 Jean-Yves Delattre,1,3 = and Marc=20 Sanson3D"corresponding1,3
1UMR975 INSERM-UPMC, GH = Piti=C3=A9- Salp=C3=AAtri=C3=A8re,=20 Paris
2UMR911-CRO2, Facult=C3=A9 de = M=C3=A9decine Timone,=20 Universit=C3=A9 de la M=C3=A9diterran=C3=A9e, Marseille
3Service de Neurologie Mazarin, GH = Piti=C3=A9-=20 Salp=C3=AAtri=C3=A8re, APHP, Paris
4Biotechnology & Biotherapy = laboratory,=20 Centre de Recherche de l'Institut du Cerveau et de la Moelle, CNRS = UMR9225, INSERM UMRS 975 Universit=C3=A9 Pierre et Marie Curie, = H=C3=B4pital de la=20 Salp=C3=AAtri=C3=A8re, Paris
5Service de Neuropathologie = Raymond=20 Escourolle, GH Piti=C3=A9- Salp=C3=AAtri=C3=A8re, Paris
6XenTech, Evry, France
3D"correspondingCorresponding=20 author.
Sandra-Nadia=20 Ngwabyt Bikeye: nmjfr/at/yahoo.fr ; Carole Colin: carole.colin/at/univmed.fr ; Yannick Marie: yannick.marie/at/upmc.fr ; Rapha=C3=ABl = Vampouille: raphael.vampouille/at/upmc.fr ; Philippe Ravassard: = ravassar/at/chups.jussieu.fr ; Audrey Rousseau: = audrey.rousseau/at/psl.aphp.fr ; Blandine Boisselier: = boisselierblandine/at/yahoo.fr ; Ahmed Idbaih: ahmed.idbaih/at/gmail.com ; Charles F=C3=A9lix = Calvo: charles-felix.calvo/at/college-de-france.fr ; Pascal Leuraud: = Pascal.leuraud/at/hotmail.com ; Myriam Lassalle: = myriam.lassalle/at/hotmail.com ; Soufiane El Hallani: = elhallanisoufiane/at/yahoo.fr ; Jean-Yves Delattre: = jean-yves.delattre/at/psl.aphp.fr ; Marc Sanson: marc.sanson/at/psl.aphp.fr
Received September 13, 2009; Accepted = January 11,=20 2010.
This is an Open Access article = distributed under=20 the terms of the Creative Commons Attribution License (http://creativecommons.org/lice= nses/by/2.0),=20 which permits unrestricted use, distribution, and reproduction in = any=20 medium, provided the original work is properly cited.
Abstract
Background
ASPM (Abnormal = Spindle-like=20 Microcephaly associated) over-expression was recently = implicated in=20 the development of malignant gliomas.
Results
To better = characterize the=20 involvement of ASPM in gliomas, we investigated the mRNA = expression in 175=20 samples, including 8 WHO Grade II, 75 WHO Grade III and 92 WHO = Grade IV=20 tumors. Aspm expression was strongly correlated with = tumor grade=20 and increased at recurrence when compared to the initial lesion, = whatever=20 the initial grade of the primary tumor. ASPM expression also = increased=20 over serial passages in gliomaspheres in vitro and in = mouse=20 xenografts in vivo. Lentivirus-mediated shRNA silencing = of ASPM=20 resulted in dramatic proliferation arrest and cell death in two = different=20 gliomasphere models.
Conclusion
These data suggest = that ASPM is=20 involved in the malignant progression of gliomas, possibly through = expansion of a cancer stem cell compartment, and is an attractive=20 therapeutic target in glioblastoma = multiforme.
Introduction
Gliomas are the most = common type of=20 primary tumors in the central nervous system (CNS), and their = usual fate=20 is to recur, either as a similar or more frequently as a higher = grade=20 lesion, explaining their grim prognosis. The cellular origin of = gliomas=20 remains unknown, but accumulating data suggest that transformed, = stem-like=20 precursors (CSC) may represent the cells that drive their growth = [1,2].
The product of ASPM gene=20 (Abnormal Spindle-like Microcephaly associated) localizes = to=20 centrosomes, spindle poles, and the midbody [3]. By promoting neuroblast proliferation and = driving the=20 orientation of mitotic cleavage, it allows for symmetric, = proliferative=20 division of neuroepithelial cells during brain development, and=20 consequently brain surface expansion [3]. Mutations within this gene produce primary = microcephaly=20 [4]. In addition to its role in embryonic = development, ASPM is=20 highly expressed in many tumor cell lines [5], suggesting an important involvement of this = gene during=20 tumorigenesis. Recent evidence suggests that ASPM is also = overexpressed in=20 malignant gliomas and that its knockdown inhibits tumor = proliferation [6,7].
In this study, we report = that ASPM=20 expression is correlated with tumor grade and increases at = recurrence or=20 after consecutive passages in vitro and in vivo. = Furthermore, we found that shRNA-mediated inhibition of ASPM = results in=20 dramatic growth inhibition and extensive cell death in=20 gliomaspheres.
Materials and methods
Patients and tissue = samples
Tumor samples = frozen in liquid=20 nitrogen were obtained from patients who underwent surgery for a = glioma at=20 our institution and gave informed consent for molecular research = studies.=20 Histological diagnoses were made according to the World Health=20 Organization (WHO). BAC-array-based Comparative Genomic = Hybridization=20 analysis (CGH-array) was performed as previously described [8]. Non-tumoral (NT) control brain (cerebellum and = white=20 matter) was obtained from injured or epileptic patients = (cryptogenetic=20 epilepsy) who underwent surgery.
Total RNA isolation, reverse=20 transcription (RT) and quantitative real-time PCR (qPCR)
Total RNA extraction was = performed=20 using RNAble blue solution (Eurobio, France) according to the=20 manufacturer's instructions. Total RNA was systematically analyzed = on both=20 a spectrophotometer and an Agilent 2100 bioanalyzer (Agilent = Technologies,=20 FRANCE). cDNA was prepared from 1 =CE=BCg RNA using a combination = of random=20 primers (48190-011; Invitrogen, France) and MMLV reverse = transcriptase=20 (28025-013; Invitrogen, France).
Gene expression was = quantified by=20 Syber Green real-time qPCR analysis (Absolute solute Syber Green = Rox Mix,=20 Abgene, Paris, France). Real-time qPCR cycles were as follows: = initial=20 denaturation at 95=C2=B0C for 15 minutes, 95=C2=B0C for 30 seconds = and annealing at=20 60=C2=B0C for 1 min. Cycles were repeated 40 times. Primers were = as follows:=20 ASPM, Quantitect Primers Assay (ref: QT00020209 Qiagen). The = amount of=20 cDNA was normalized to the amount of the ALAS = housekeeping gene=20 (Human Erythroid 5-Aminolevulinate Synthase) using primers F:=20 5'-TGCAGTCCTCAGCGCAGTCT-3' and R: 5'-TGGCCCCAACTTCCATCAT-3'. The=20 2-=CE=94=CE=94CT equation was applied to calculate the = relative copy=20 number of tumor samples versus non-neoplastic=20 tissues.
Cell Isolation and = culture
Briefly, tumors were = immediately=20 collected after surgery in HBSS (14175, Invitrogen) and dissected = after=20 removal of gross necrosis, subjected to a trypsin digestion (5 = mg/mL) for=20 10 min at 37=C2=B0C, and then trituration and filtering. The cell = suspension=20 obtained was then plated at a density of 5.105 cells/75 = cm2 flask (Corning, FRANCE) in 10 mL of DMEM/F12 medium = supplemented with Insulin (5 mg/mL), Penicillin - Streptomycin (50 = mg/mL)=20 and growth factor (bFGF; 20 ng/mL), epidermal growth factor (EGF; = 20=20 ng/mL) and B27 (1/50) as a stem cell-permissive medium and = maintained in a=20 5.0% CO2/95% O2 atmosphere with 100% humidity. Cultures were fed = every=20 three days by changing half of the medium. Primary gliomaspheres = were=20 obtained after 5-10 days.
The U87 and U251 = glioblastoma cell=20 lines and the HEK293T kidney cell line were purchased from ATCC = (American=20 Type Culture Collection, USA), grown on DMEM 10% FCS- 1%=20 Penicillin-Streptomycin, and used as controls for in vitro=20 experiments.
LV-shRNA transduction and = viability=20 Fluorescence-activated cell sorter analysis of Gliomaspheres
We used pGIPZ (RHS4287, = Biovalley=20 FRANCE) lentiviral vectors expressing a short hairpin RNA (LV- = shRNAmir,=20 Biovalley, FRANCE) for ASPM silencing (sequence:=20 = TGCTGTTGACAGTGAGCGCGGCATTGGCGTGCTTATTTAATAGTGAAGCCACAGATGTATTAAATAAGCACGC= CAATGCCTTGCCTACTGCCTCGGA=20 or a scrambled non-targeted shRNA (RHS 4346; Biovalley FRANCE.) as = a=20 control.
Lentiviral vector stocks were = produced by=20 transient transfection of HEK293T cells with the p8.91 = encapsidation=20 plasmid [9], the VSV glycoprotein-G-encoding pHCMV-G plasmid = [10], and the lentiviral recombinant vector as = previously=20 described [11]. Supernatants were treated with DNAse I (Roche = Diagnostic) prior to ultracentrifugation, and the resulting pellet = was=20 resuspended in Phosphate Buffered Saline, separated into aliquots = and=20 frozen at -80=C2=B0C until use. The transduction efficiency of = each vector=20 stock was determined by FACS analysis as previously described [12].
Gliomasphere cultures = were=20 mechanically disaggregated in order to increase the efficiency and = uniformity of infection and then transduced at 3-5.106 = cell/mL=20 with LV-sh-miR of ASPM and non-targeted shRNA at a multiplicity of = infection of 2.5 (MOI: number of transducing units per cell) = supplemented=20 with DEAE dextran (20 =CE=BCg/mL). After expansion of the culture, = GFP-positive=20 viable cells were separated by cell sorting and flow cytometry = FACS (FACS=20 Aria=E2=84=A2 PQ1300010, BD Biosciences) to ensure knockdown = efficiency. After 7=20 days, ASPM RNA expression was measured in glioma stem cells = infected with=20 lentiviruses by real-time qPCR.
Proliferation and cell death=20 quantification
Proliferation was = assessed by=20 EDU incorporation (Click iT=E2=84=A2 EdU Flow Cytometry Assay = Kits, A10202=20 Invitrogen), and cell death by 7-AAD+cell staining. The = percentage of labeled cells was quantified by cell sorting on flow = cytometry FACS (FACS Aria=E2=84=A2 PQ1300010, BD = Biosciences).
Subcutaneous Xenograft = formation=20 assay
2 to 5 =C3=97 = 105 cells=20 suspended in 100 =CE=BCl of HBSS medium were injected = subcutaneously into=20 nude mice. Before xenograft establishment, tumors were = passed=20 four times and genomic stability was checked by CGH array=20 analysis.
ASPM Immunofluorescence
To detect the = endogenous ASPM=20 protein, cultured cells were fixed for 15 min in 4% = paraformaldehyde,=20 washed twice in PBS, treated for 30 min with 0.1 Triton X-100 -5% = FCS, and=20 incubated for 30 minutes at room temperature with Rabbit-anti-ASPM = (IHC=20 Antibody Affinity purified Cat IHC_00058 BETHYL, dilution 1:50) in = 0.1=20 Triton X-100 -1% FCS. After two washes in 0.1 Triton X-100 -1% = FCS,=20 samples were incubated for 30 minutes at room temperature with = goat=20 anti-rabbit IgG-FITC (dilution 1:1000) in 0.1 Triton X-100 -1% = FCS. After=20 two washes, samples were stained with Hoechst solution and rinsed = with=20 PBS. Samples were mounted with Fluoromount=C2=AE = (0100-01,=20 SouthernBiotech, France). Images were captured with a Zeiss = microscope=20 (Axiophoto) equipped with a cooled CCD camera (Cool SNAP HQ, = Photometrics,=20 Tucson, AZ, USA and analyzed by IPLab software).
Protein extraction and ASPM = Western=20 blot
Total protein, = obtained by=20 lysing tumor tissue or cells with RIPA 1=C3=97 buffer (SDS 20%, = NP-40 20%,=20 Deoxycholate acid 10%, Tris-HCl 2 M pH: 8, NaCl 5 M for 10=C3=97 = buffer) was=20 quantified using a Pierce BCA=E2=84=A2 Protein Assay Kit (ref = 23225 Pierce, USA),=20 separated on Nu-Page 3-8% Tris-acetate polyacrylamide gels = (Invitrogen),=20 and electro-transferred to nitrocellulose membranes (Bio-Rad = Laboratories,=20 Inc.) in 25 mM Tris, 192 mM glycine, 20% ethanol, and 0.01% SDS = for 2.5 -=20 3 hours at 80-150 volts. After blocking in 5% milk solution, the = membranes=20 were probed with anti- ASPM (K-17 sc-48883) and anti- GAPDH (V-18=20 sc-20357) both from Santa Cruz Biotechnology, Inc., U.S.A. = Antibodies were=20 diluted 1:500 for ASPM and 1:700 for GAPDH in TBST (50 mM Tris = Base, 150=20 mM NaCl, 0.1% (v/v) Tween-20) containing 5% milk powder. After = washing in=20 TBST, the membrane was incubated with appropriate horseradish = peroxidase=20 (HRP)-conjugated secondary antibodies diluted 1:5000 in TBST. The=20 immunoreactive signals were detected using an ECL reagent Advance = Western=20 Blotting Detection Kit (GE Healthcare) and an Image Reader = LAS-1000=20 Pro ver. 2 (KODAK PHOTO FILM 4000 mm, FRANCE).
Statistical analysis
The =CF=872 = test was used=20 to compare qualitative variable distribution, and the Mann-Whitney = test=20 was used for continuous variables. A two-sided p-value < 0.05 = was=20 considered to be significant.
Results
1. ASPM expression increases = with glioma=20 grade
We measured ASPM = expression via=20 qRT-PCR in 175 gliomas (8 Grade II, 75 Grade III and 92 Grade IV) = and in=20 three non-neoplastic brain tissues (NT). ASPM expression level = increased=20 between NT tissue and Grade II gliomas (p < 0.05), between = Grade II and=20 Grade III (p < 0.005), and between Grade III and Grade IV (p = =3D 0.0001).=20 ASPM expression did not differ between astrocytic (2 AII, 36 = AIII),=20 oligodendroglial (1 OII, 13 OIII) or mixed glioma samples (5 OAII, = 26 OA=20 III) (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure1a1a3D"Figure).
Preliminary results with = western blot=20 analysis showed that ASPM was also expressed at the protein level = in=20 gliomas and overexpressed in Grade IV gliomas as compared to = Grades III=20 and II (additional file 1, Figure S1).
2. ASPM is upregulated in = recurrent=20 gliomas relative to the initial tumor
ASPM mRNA = expression was=20 measured in 11 recurrent tumors and compared to the initial tumor = (3 Grade=20 II, 1 Grade III and 7 Grade IV). As shown in Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8BFigure1b,1b3D"Figure,=20 increased malignancy at recurrence was identified in all 4=20 non-glioblastoma patients with concomitant increase of ASPM = expression in=20 all of them. In the 7 patients whose initial tumor was a GBM = (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure1c),1c3D"Figure),=20 ASPM expression was 3.5-fold higher in the recurrent tumor = although the=20 grade did not change (p < 0.005).
3. ASPM expression increases = with the=20 number of passages in gliomaspheres and in xenografted = tumors
Because ASPM expression = increases=20 with the recurrence of glioma, and because ASPM is involved in = tumor stem=20 cells, we investigated ASPM expression over time in vitro = in=20 spheroid cultures and in vivo on xenografts
We generated three gliomaspheres = cultures,=20 GBM1, GBM2, GBM3, all characterized by EGFR amplification and 10q = loss on=20 CGH-array analysis; this genetic profile remained stable = throughout the=20 passages (as shown in additional file 2, Figure S2 for GBM1). We also verified the = capacity of=20 gliomaspheres to differentiate in the presence of fetal bovine = serum and=20 to express multilineage markers (additional file 2, Figure S2). = After=20 dissociation of gliomaspheres, ASPM was detected during mitosis = and=20 located at the spindle poles of dividing cells (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure2a).2a3D"Figure).=20 ASPM transcript expression significantly increased throughout the = passages=20 for all gliomaspheres studied (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure2b).2b3D"Figure).=20 For example, in GBM1 gliomaspheres, we observed a 6.5-fold = increase in=20 ASPM mRNA level between passages 8 and 28.
3D"Figure
<= STRONG>Figure=20 1
Aspm=20 expression correlates with glioma grade and increases = at=20 recurrence. (a) Aspm is=20 up-regulated in gliomas compared to non-tumor brain and = increases=20 with the tumor grade;(b) ASPM expression = increases=20 between the initial tumor and recurrence at a = higher = (more ...)
After four passages and = after=20 checking genomic stability via CGH-a (not shown), 500,000 = dissociated=20 cells from GBM1 gliomaspheres were injected subcutaneously into=20 immunodeficient nude mice. ASPM mRNA, measured by RT-PCR, = increased=20 progressively with successive tumor passages (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure2c2c3D"Figure).
4. ASPM silencing inhibits cell = proliferation/gliomasphere formation and promotes cell death
To determine the = role of ASPM,=20 we infected gliomaspheres with lentivirus expressing a sh-miR-RNA = that=20 specifically target Aspm. In GBM1, GBM2 and GBM3 = gliomasphere=20 models, ~80% of cells were successfully transduced with the = sh-miR-RNA=20 specific to Aspm. In transduced cells, ASPM expression = measured=20 by RT-PCR was dramatically reduced to less than 5% in GBM2 and = less than=20 0.02% in GBM1 and GBM3 (additional file 3, Figure S3). We then analyzed cell kinetics in = three=20 different groups: non-transduced cells, cells transduced with the=20 non-targeted sh-miR-RNA, and cells transduced with = sh-miR-Aspm.=20 After day 5, cells transduced with the non-silencing sh-miR-RNA=20 proliferated again while the sh-miR-Aspm cells died = (Figure <= SPAN=20 style=3D"TEXT-DECORATION: underline">3a-b3D"Figure).=20 The morphology of the cells is shown at day 33 in Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8BFigure3c3c3D"Figure=20 and <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8Band3d.3d3D"Figure.=20 We then quantified the effects of Aspm silencing on = proliferation=20 (assessed by 5-Ethyl -2'-Deoxyuridine (EdU) incorporation) and = cell death=20 (assessed by 7-AAD+ labeling). We noted an accumulation = of dead=20 cells in sh-miR-Aspm populations (80% of = 7-AAD+GBM1,=20 as shown in Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8BFigure4b,4b3D"Figure,=20 and 85% of 7-AAD+ GBM2) compared to control (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure4a).4a3D"Figure).=20 In addition to cell death, ASPM inhibition resulted in a decrease = in=20 proliferation: in sh-miR-Aspm GBM1 gliomaspheres, only = 25% of the=20 viable cells (i.e., 5% of total cells) were EdU+ cells (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure4d),4d3D"Figure),=20 compared to 64% in the non-silenced cell population (Figure <= SPAN=20 style=3D"POSITION: relative; TEXT-DECORATION: none">=E2=80=8B(Figure4c).4c3D"Figure).=20 For GBM2, the results were similar: 4% of 15% of viable cells were = EDU+ in=20 sh-miR-Aspm GBM2 gliomaspheres vs. 81% in = control GBM2=20 (data not shown).
3D"Figure
<= STRONG>Figure=20 2
ASPM=20 expression in gliomaspheres increases with successive = passages=20 in vitro and in vivo. (a) = Metaphase staining of ASPM protein at both poles of = the=20 spindle. ASPM protein (green) is detected in gliomaspheres = (arrow).=20 Nuclei are stained with DAPI (blue); = (more ...)
3D"Figure
<= STRONG>Figure=20 3
ASPM=20 knockdown in glioblastoma gliomaspheres. Cell = kinetics of=20 GBM1 (a) and GBM2 (b)=20 gliomaspheres. The data were generated from three=20 independent experiments. Gliomaspheres treated with = sh-miR-Aspm=20 do not grow as compared to non-transduced=20 gliomaspheres = (more ...)
5. ASPM silencing inhibited = gliomasphere=20 formation of GBM cancer stems cells
In order to = evaluate more=20 specifically the impact of Aspm silencing on GBM cancer = stem=20 cells, we conducted a secondary gliomasphere-forming assay in = GBM1. Seven=20 days after silencing, GFP+ cells were sorted and = re-incubated=20 at 1,000 cell/10 mL. We observed a dramatic decrease in cell = number in=20 GBM1 sh-miR-Aspm compared to the non-silenced control = (1000 cells=20 vs. 2.8.105 cells at day 9 and 500 cells = vs.=20 3.7.106 cells at day 15). At D15, no gliomaspheres were = observed (vs. 91 gliomaspheres in the control), = indicating that=20 the knockdown of Aspm completely abrogated the = development of=20 secondary gliomaspheres.
Discussion
This study indicates = that ASPM is=20 tightly associated with the malignant progression of gliomas and = that its=20 knockdown produces extensive death of glioma cells in=20 vitro.
As previously described [7], we found that ASPM expression was strongly = correlated=20 with the grade of gliomas. In recurrent tumors, ASPM expression = increased=20 not only in patients who progressed to a higher grade, but also in = recurrent glioblastomas, suggesting that a progressive increase in = ASPM=20 mRNA expression is a marker for the inexorable malignant = progression and=20 aggressiveness of gliomas, continuing even when the tumors have = already=20 reached their most anaplastic histological stage (Grade IV). = Experimental=20 evidence supports this finding since we found a progressive = increase in=20 ASPM mRNA expression in serial passages of gliomaspheres in = vitro=20 and in mouse glioma xenografts in vivo. To explain = such a=20 tight correlation between ASPM expression and the malignant = progression of=20 tumors, an attractive hypothesis is that symmetric division of=20 CSC-expressing ASPM leads to progressive proliferative expansion = of this=20 undifferentiated compartment. Although we found that ASPM was also = expressed at the protein level in all glioma grades and = overexpressed in=20 Grade IV gliomas, it is worth noting that the results were less = striking.=20 This finding has been previously noted and led to the suggestion = that ASPM=20 could be in part regulated at the translational level [7]. However, the dramatic inhibition of = gliomasphere=20 proliferation obtained with shRNA-mediated ASPM knockdown = highlights the=20 potential importance of this gene in malignant gliomas. Sphere = formation=20 is a key behavior of neural and brain tumor stem cells and is used = to test=20 stem cell capacity for self-renewal. A previous study also showed = that=20 siRNA-mediated inhibition of ASPM resulted in cell proliferation=20 inhibition, thought to be mediated by a G1-phase cell cycle arrest = [6]. The effect that we observed here by stable = transduction=20 of shRNA expression in CSC-enriched cells appears even more = drastic,=20 possibly because of a more efficient and longer lasting inhibition = of=20 ASPM. Whereas siRNA transfection results in a transient = effect,=20 lentiviral-mediated expression of shRNA allows the transgene to = integrate=20 into the genome of the host cell, resulting in long-term = expression.=20 Production of secondary spheres was also inhibited after ASPM = knockdown, a=20 finding compatible with a sustained inhibition of CSC = proliferation.=20 Interestingly, stable inhibition of ASPM not only prevented = further growth=20 but also produced rapid and extensive cellular apoptotic death in = our=20 model. This finding may indicate that, following ASPM inhibition, = CSC=20 underwent active maturation and differentiation but could not = survive in=20 our experimental setting (serum-free medium without appropriate = growth=20 factors). However, experiments by Horvath et al. = conducted in a=20 similar serum-free medium resulted in growth inhibition and not = massive=20 cell death. On the other hand, the function of ASPM in = neoplastic=20 cells, particularly gliomas, has not been completely elucidated. = In=20 particular, the links between ASPM and key molecular alterations = of=20 malignant gliomas, such as EGFR amplification or mutation = (EGFRvIII) (an=20 almost constant feature in gliomaspheres - 80% in our experience), = remain=20 to be investigated. Nevertheless, some data suggest that these = alterations=20 are closely related. ASPM mRNA expression was increased in an=20 EGFRvIII-expressing U87 glioblatoma cell line as compared to an = isogenic=20 U87 line, while ASPM expression was inhibited following the = addition of=20 erlotinib (an EGFR tyrosine kinase inhibitor) to the = EGFRvIII-expressing=20 U87 line. This observation led Horvath et al to suggest = that ASPM=20 (and genes from the same module) is involved downstream of the = mutant=20 EGFR. Thus, inhibition of ASPM could prove lethal by severely = hampering=20 one of the key signaling pathways of glioblastomas.
Because ASPM is absent or = expressed=20 at very low levels in normal brain, the considerable differential=20 expression levels between GBM and normal parenchyma and the = extreme in=20 vitro sensitivity of tumor cells to ASPM knockdown support = continued=20 research to specifically target ASPM from a therapeutic = perspective,=20 focusing on in vivo studies.
Competing interests
The authors declare = that they=20 have no competing interests.
Authors' contributions
SNNB, CC and YM = carried out=20 most of the in vitro work. RV and PR produced the lentivirus. = SNNB. AR and=20 BB performed the immunohistochemistry experiments. AI performed = the=20 CGH-array experiments. PL and ML did the in vivo experiments. SEH=20 contributed to the in vitro experiments. MS conceived the study. = JYD and=20 MS wrote the manuscript. All authors read and approved the final=20 manuscript.
Supplementary=20 Material
Additional file 1
Figure S1 - ASPM protein=20 expression. ASPM western blot analysis of grade II, III = and IV=20 gliomas (n =3D 4 in each group). Relative protein expression is = presented as=20 the ratio of density value for ASPM over GAPDH signal (mean +/-=20 SEM).
Click=20 here for file(185K, PPT)
Additional file 2
Figure S2 - Tumor spheroid = characterization. Genomic stability was examined with = CGHa=20 analysis (left =3D DNA profile from initial tumor; right =3D DNA = profile from=20 gliomasphere at passage p28). The chromosomes are indicated on the = x axis=20 and copy number is on y axis. Yellow indicates the normal genomic = copy=20 number, while green indicates a loss and red indicates a gain in = copy=20 number. As shown here, GBM1 carries EGFR amplification and loss of = chromosome 10q. After CSC isolation in stem cell-permissive = medium,=20 gliomaspheres were differentiated in presence of fetal bovine = serum and=20 stained by Sox2 and O4 for stemness markers and by GFAP and Tuji1 = to=20 characterize the potential of multi lineage differentiation of = GBM1.
Click=20 here for file(889K, PPT)
Additional file 3
Figure S3 - Knock-down of = Aspm=20 gene. Tumor spheroids (GBM1, GBM2, GBM3) were transfected = either=20 with non silencing (scrambled ShRNA) or with ASPM ShRNA expressing = lentivirus, resulting in a dramatic drop of ASPM RNA in GBM1, GBM3 = and to=20 a lesser extent GBM2.
Click=20 here for file(109K, PPT)
Acknowledgements
This work was = supported by the=20 Institut National du Cancer (PL 046) and the Ligue Nationale = contre le=20 Cancer. SNNB is supported by a grant from the ARTC (Association = pour la=20 Recherche des Tumeurs C=C3=A9r=C3=A9brales).
References
  • Galli=20 R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, = Fiocco R,=20 Foroni C, Dimeco F, Vescovi A. Isolation and characterization of = tumorigenic, stem-like neural precursors from human = glioblastoma.=20 Cancer Res. 2004;64(19):7011=E2=80=937021. doi:=20 10.1158/0008-5472.CAN-04-1364. [PubMed]
  • Singh=20 SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman = RM,=20 Cusimano MD, Dirks PB. Identification of human brain tumour = initiating=20 cells. Nature. 2004;432(7015):396=E2=80=93401. doi: = 10.1038/nature03128.=20 [PubMed]
  • Fish=20 JL, Kosodo Y, Enard W, Paabo S, Huttner WB. Aspm specifically = maintains=20 symmetric proliferative divisions of neuroepithelial cells. = Proc Natl Acad Sci USA. 2006;103(27):10438=E2=80=9310443. doi:=20 10.1073/pnas.0604066103. [PubMed]
  • Bond J,=20 Roberts E, Mochida GH, Hampshire DJ, Scott S, Askham JM, = Springell K,=20 Mahadevan M, Crow YJ, Markham AF. ASPM is a major determinant of = cerebral cortical size. Nat = Genet.=20 2002;32(2):316=E2=80=93320. = doi:=20 10.1038/ng995. [PubMed]
  • Kouprina N, Pavlicek A, Collins = NK, Nakano=20 M, Noskov VN, Ohzeki J, Mochida GH, Risinger JI, Goldsmith P, = Gunsior M.=20 The microcephaly ASPM gene is expressed in proliferating tissues = and=20 encodes for a mitotic spindle protein. Hum=20 Mol Genet. 2005;14(15):2155=E2=80=932165. doi:=20 10.1093/hmg/ddi220. [PubMed]
  • Horvath=20 S, Zhang B, Carlson M, Lu KV, Zhu S, Felciano RM, Laurance MF, = Zhao W,=20 Qi S, Chen Z. Analysis of oncogenic signaling networks in = glioblastoma=20 identifies ASPM as a molecular target. Proc Natl Acad Sci USA. 2006;103(46):17402=E2=80=9317407. doi:=20 10.1073/pnas.0608396103. [PubMed]
  • Hagemann C, Anacker J, Gerngras S, = Kuhnel S,=20 Said HM, Patel R, Kammerer U, Vordermark D, Roosen K, Vince GH.=20 Expression analysis of the autosomal recessive primary = microcephaly=20 genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal = spindle-like,=20 microcephaly associated) in human malignant gliomas. Oncol Rep. 2008;20(2):301=E2=80=93308. [PubMed]
  • Idbaih=20 A, Marie Y, Lucchesi C, Pierron G, Manie E, Raynal V, Mosseri V, = Hoang-Xuan K, Kujas M, Brito I. BAC array CGH distinguishes = mutually=20 exclusive alterations that define clinicogenetic subtypes of = gliomas.=20 Int J Cancer. 2008;122(8):1778=E2=80=931786. doi: = 10.1002/ijc.23270.=20 [PubMed]
  • Zufferey R, Nagy D, Mandel RJ, = Naldini L,=20 Trono D. Multiply attenuated lentiviral vector achieves = efficient gene=20 delivery in vivo. Nat = Biotechnol.=20 1997;15(9):871=E2=80=93875. = doi:=20 10.1038/nbt0997-871. [PubMed]
  • Yee=20 JK, Miyanohara A, LaPorte P, Bouic K, Burns JC, Friedmann T. A = general=20 method for the generation of high-titer, pantropic retroviral = vectors:=20 highly efficient infection of primary hepatocytes. Proc Natl Acad Sci USA. 1994;91(20):9564=E2=80=939568. doi:=20 10.1073/pnas.91.20.9564. [PubMed]
  • Zennou=20 V, Petit C, Guetard D, Nerhbass U, Montagnier L, Charneau P. = HIV-1=20 genome nuclear import is mediated by a central DNA flap. = Cell. 2000;101(2):173=E2=80=93185. doi:=20 10.1016/S0092-8674(00)80828-4. [PubMed]
  • Castaing M, Guerci A, Mallet J, = Czernichow=20 P, Ravassard P, Scharfmann R. Efficient restricted gene = expression in=20 beta cells by lentivirus-mediated gene transfer into pancreatic=20 stem/progenitor cells. Diabetologia.=20 2005;48(4):709=E2=80=93719. = doi:=20 10.1007/s00125-005-1694-6. [PubMed]
Articles from Cancer Cell=20 International are provided here courtesy of
BioMed Central
3D"Figure
<= STRONG>Figure=20 4
Cell death=20 and proliferation inhibition induced by ASPM silencing, = evaluated by=20 7-Actinomycin D (7-AAD) labeling and 5- Ethyl -2'- = Deoxyuridine=20 (EdU) incorporation. Compared to control = (a),=20 transduction of GBM1 with sh-miR-Aspm = results in=20 massive cell = (more ...)

PubMed articles by these = authors

  • Bikeye,=20 S.
  • Colin,=20 C.
  • Marie,=20 Y.
  • Sanson,=20 M.

PubMed related articles

  • Expression=20 analysis of the autosomal recessive primary microcephaly genes = MCPH1=20 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, = microcephaly=20 associated) in human malignant gliomas.=20

    Oncol Rep. 2008 Aug; = 20(2):301-8.

    [Oncol Rep. 2008]

  • ASPM=20 is a novel marker for vascular invasion, early recurrence, and = poor=20 prognosis of hepatocellular carcinoma.=20

    Clin Cancer Res. 2008 Aug 1; = 14(15):4814-20.=20

    [Clin Cancer Res. 2008]

  • miR-124=20 and miR-137 inhibit proliferation of glioblastoma multiforme = cells and=20 induce differentiation of brain tumor stem cells.=20

    BMC Med. 2008 Jun 24; 6:14. Epub = 2008 Jun=20 24.

    [BMC Med. 2008]

  • ReviewMolecular biology of malignant=20 gliomas.=20

    Clin Transl Oncol. 2006 Sep; = 8(9):635-41.=20

    [Clin Transl Oncol. 2006]

  • ReviewPresent and potential future = adjuvant=20 issues in high-grade astrocytic glioma treatment.=20

    Adv Tech Stand Neurosurg. 2009; = 34:3-35.=20

    [Adv Tech Stand Neurosurg. 2009]

  • =C2=BB See=20 reviews... | =C2=BB See=20 all...

Recent Activity

=20
Clear=20 Turn=20 Off Turn=20 On

Your browsing activity is empty.

Activity recording is turned off.

Turn=20 recording back on

Links

  • PubMed=20
  • Taxonomy=20
  • Taxonomy=20 Tree
See=20 more articles cited in this paragraph
See=20 more articles cited in this paragraph
See=20 more articles cited in this paragraph
See=20 more articles cited in this paragraph
See=20 more articles cited in this paragraph
You are here: NCBI > Literature = > PubMed=20 Central
Write to the Help Desk =20

Simple NCBI Directory

Copyright = | Dis= claimer=20 | Privacy | Accessibili= ty |=20 Conta= ct=20

National Center for Biotechnology=20 Information, U.S. National Library of = Medicine=20 8600 Rockville = Pike, Bethesda MD, 20894 USA=20

------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/pmc3_logo_v5.gif R0lGODlhkQBLAMYAAKm5x+v0+IekvHefv+Tp7liXuQBcknmcuoapxDqGrsXP3yhpmrnEzrzL3FqG qgFmmTp1os7W3YWyysPT4Uh4peHn7Oru88TN1ip7p8nS2Rxjl6zB1ejs8d3k6mmStfP6+6zE2Nrg 5kKLsb7I0bbBy9Lm7sfP2HKlwy9tnLnU4pGswaW+0kyCqpvB1bfJ3GWRs9La4A5YkGGcvOLo7a/N 3dvi57nQ3qLD1s7c5pq1y6+8x5+zxLDG2JK4ztXc45e80cLZ5drq8eXq78vg6rXG1HmrxmGOsMne 6WCKrtnf5ZGyy1mKsDVyoMrT4rvGz3Cau9/l68PM1cDJ0k6Stunt8Rdvn2mhv1N9qNfg6dDX39Pe 6n+uyIe40MHL1OTv9XWoxefr76DG2Nbd4+Lu9J+4zRlflNnj68Xe6pexxu7w8dHa59nd6afJ2uvu 8G6Wtufs8OHo8dTb4urt8MvU2+zv9dLc5evu9ezr8maUtwBPiuzx9P///2aZzDNmmczY5Ozw9CwA AAAAkQBLAEAH/oB7goOEhYaHiImKi4yNjo+Qinx+lJWWl5iZmpuclX+foKGio6SlpqeoqaJ8gpOd lVhbVhJee2NAXC1DjEGyWxWvnqqhEHlLG0t5eTkVBG9UFp88ymBCQs/TMXksFRN52hAVMwRg0KPT edXX5qase66YTywe9EYoGgv5GvP19/ooSzy88LAEn74qCaYonFJFgxJNw0BRKebhghMGDJwgURaj TB4kAvIwUZbHDYOQKEg4yHMFwMoFOnRoIAmBBAkUynDmIcGgS4QkFai0a7XpxA8FE04YuCGkQgUw Mno0aFAgT4+mFYRIAOGiiQgDNmZAgTLDBgikCQy0mAExIigL/nA74IEAQYkFKlTe6H3DAS+Hv33x WuDBwwzew9AQBx4wwM/evnBRuYN3yUoCGQVkMDRAgwCBLwkyY66yFMyME1MKqC7wIAEUpxIuiyYN pK3bT1S0LTHBQNuAYi9MqDCiQoWyC8bzSBmhTACDlShGSNEmwAROI8zzqBgRJYKYDmCinZocrLz5 87dD3W3aIUSSJCFqdOhQo379+fjz068RIr78+fz1199/ZAnBznhEVeJBHwzq4aCDDEYo4YQUVtgH hBZ6cEkoZFiIoYUghjjhhxfqMaKJHkpIRijkVaIABSLGKCOIFEywoURIzKjjjjyCiIRQoLR43pBE 3pjekUgm/hlkgkU2OaSSUEY5jJBOFhHaLnsEcYIIJzgpjJRghrnkO5mgwUIZEDiAhANXoLDAFQ6w ecWcdNZp5510rolCGS8QkcltFhRDUkkM4PTCHCO5QYYyGUShDBo5iBRSMUhshIITOJXBhEduuCFS EovmYYIJGcBQwwxAkkLlJUWwsYYWWzyAQQK00npDE2pURasIIiSAwQRNmDGFARj0SusPE7z6FRub AApGBTX4AIMPIXQARQdJZJHBBVF00cUFJkQB7qgZzDFHBuVmQCq65Z5LLrrmqktuFklAIYR4qjKJ yRc0YNHAF0sR4BRUNkxV1VUD93BEV1+FNd8MKQDRxARp/rXQ7JHe5LFCEjAI0CcR3zwRQwxYgKCM BjPFQICgInlaTF15oDCAMmTMoMzGSXSQVapDkenlz68gScUMNcDQaBfiXsDtCBg54bR0F40wghPS Lef000hHIcVFNvFE9QX0QvFGKqsCbbYlYqYNJpUUPtjggx/CXWKEJM5tt4RG/gEihBjyjaLfdP+N YomAB34i4YPXzaK+Zzfuh9qQK1m240BHbnl6k1Pu5eWcT8n4z7063vnoCPpMpAQFbFFLALi0EAAh eqAmQZPpKcEYYyvAhS8oODAmSu+M4QCX7QPYtfsowLuVeSU9bLFFEIIMEQYbQHwQCSFAfLHFDx1w Amgx/k+IcYEyLyTaQTEDbKAMBRSI1MEKeUAwEhEs5OGBSFmAHIPIJGOhDR46SYIYcjaD8PSMMpVQ AQ6ux8BBNOAKf3JLoOx3AQZ0DSdIGMF1kmPBRxkHBQzwSB508BIdjAQJUhiOCjyFAuEoAyPdAQrP VvE5SmAGAzjEQBUewEMe5hCHO+yhrH4oRB8SsQo4sM0wLECAom3rAhmIQBayMAeLYKRrFvRaRqSG kSzypGlTa9rTwrhFE8AgBEE5YFGOkhQDsCENcpBDGqJisDz8AI5y3ArDDDCDNoABDG1IwVkoppaL SfANQpiBOK7BATAQAAo1eM97BAQf/1hLP/q5ln3u/kMfAcmngAcaxfKMghSl3OCRWaEjVazySCgQ QI9eAUsF5lMBs6ClkEq8TTJiQAYEKGMCzXjG8UahDBD8UZimKKY1yhEZydSQElsowR7SsAU3vmEc crBCLTpQlR/IQQiAnMLr7jAsIGAFDH6wHhy+EgZD3gYdZKiity6QqU2VJFSgUkYcYPCoCxghD2WI wLQ24AYmaMMN/MwDGsp1xgqMzZmmu0QPEmCFihZBBAvAgrV+IIKKVlQEGMBBBaAgg4561FdmmM8P MCCBim5BBFWoTQTTw4E6jIQkByjXAmhCgpDk4SQvJIGgUAAdnugkBsVwgA6awwApzOE7BiwdAjX3 /jMkWeCaNYjDHEa1LneRilTmOldY5xABr4JVimU1gdKiEAWwZuE7qCLbM6laJCjBBS98QYxfAqNX vXJAL3z1C2D5qjvPRdQPIIBRjxY7IQqAABOigEKOGEvZyk4ICVCgYUQN1za3va1vnpXb3OrGoLzt TXCgfRviEJe40A7ubqpdrWgZtLjNxna0grNb4XRrotROKG+KjW3hhtvb1qo2tSSqG3FhS4HaTrUJ AoCAZXcEAQE0YaYSIUNwp8tdGVGADDP8w/Lo+iTSmVezDUyvetfL3vZKgg/wja9850vf+tr3vvjN r373y9/++pe+cyUves5LYPEGWMDlKTCBx4vg/mAo+LwMbnAnHmzeCAfjDUoQgQxK+oWzUZh0Fi7K FE4AvQAM4XV78MJLt7C5D3cuxJYoQgG+UAsvpIALXMCSIbRwggIUwQzldQvLlMECMAgTX+i4CzQG Q5IB/GUm8fvLkkmRZMEMU7NTzcQNkEWDAHzgCC2gARCk+QgvsIEGPbiBg28DPmwpww1GgIAKhDAX JaDjBXlYgAsIYLJixCAEvmwfE/qTg5mgwAZwWcFMkpGHkRYolFjeBGa+AAQH0aAIW6ABHOwgBDh4 +tOgDnWohUAHOgDBCiLocC5TMUEmeGCnedgBTjwghpE8AX6iAlkeXLAoJiTjAGVAAZ5RcAE8/i8h CU9YRqQ0UIFI5SELUswZAa78ickJQAVNaAAPQLABHrigAS4AgbjHTe5ym/vc3vbDACAIWQkWgwVo UMEFPxKFWaNBGVJggDKKEzMAkEQARcWJsF/wAjTgmQlZuHcepAY2NIZ3TFl2AxoasIINWLwBCsh4 xnlg8YtrPOPc7vjHQb6CG5jcBUCILnZVMREKehEnEDiANkDSnAN8A6gpGckCXJJnHbCwUNpROAk2 8tOe/CSNpcicBMKwhwAEoARp6aEBwuD0p3+Fh8QCQtWHIEQDVIEGH/BCAMaQgDxgYdWosIALVkAE EyxHXCY4gBEAoAIB7AAAAsC7AwTAE7yj/oEBeN+BDuoub5u4wQFu6JoOBqIDATiHAVGgF9LzdVhL pKYIJ0hAEXlYgBOcAAMGKGIVZHCCLwRRiBiwwhdOsMMioHPlrBZCB8RQ1jnAYIBiMFoXyEg1p0nh 99+6QBeksHupER9pwgf+PIVftShkIA6neni150pKBSilB2nI/hx78O2qbEH7FdgCVybwFRxoPw00 OIsNKuZOVdzlkfdpRiKhwDFoR0CKU8Q/DG4vBh/4QAz7FAf+938AuH/7FwdikHtTlAW31wEz8AbU ZmCVVwmk1EY3wAGeIQeqdDAYSAByAEsNc062REgWg3ZpdxdvYGRLRgUckEhO4RQzoEgv/jgO1lCD QuAZNniDMbiDnhGDMOgMkBZpmlCBpoRKQrCBrDQWr8QVsWQDs6QzI8h+JqgKOKANJIEH4AQZEfgJ ysADutNMo2ABXXgYYChVa1RKAfMaR/gDddQDApMVIAgWM/AwUYhLsBcRyvAEkDQTCJAEhRYziGYD dKEEI2MXeJATL6ACdbEEEGABA5AyA3AXyrABYzEDQsABWzh9E0gJRXAGadAAShEGWPEGMlACarBK PWAaHigCXqAGTdhKBDABY9AB62eH7ZYe6LACRqNWJoBnRhACyZYDuFYHuEYfNBMB95MHRkAECAAB K3A+efAENUAzDAhX0udcm4ABUyAB/lZiAAXgSARgBhiQOlZAGlPwR2BwA6NXBKb3ACeAFVggA7Nw AhpgAFPQfhHhB8qQA40id2QwEkxAcAWncBGgcOqybyNgKeAyMzFwJnkQHPvWVmHzUGaYCSfABSVw BEOQAmVHA+JgBT0wBBrJkXlwSlAgAmwgkkeQAjxkLRXQAxipkWcAejJ1i7fBAcmWBw6AEzHQBSjR BThRd8owAj6FEcqABCoAHRnRHDtwlPqWBwLgBF3wVOCRiTAmYTbpFlRQAUkwHG4AAOMSd0iQeCTQ eFFplhakA0+ABAewA9d2RR6ABADgloLneDpgdFAlV5uIlUFzJBYge7QXLmylNOEC/nzEt1bBB3fc 4i3ztC7MNzVUgzSlgkYcoJdZxpd9eSRU0BTRsoAM6AP7ZIDT0n8C2H8JKC0wMEX7l4AKaH8MKIA5 kxWZKIGXiZnekyR34UgzSAA6uIPj4BnAyZu9CYM0SAA+uJu8iUyWaZtB5mJlGCZl0wQH0F06cgDX lZV/YAHaRZ3cGSLfNUxU0gDS1Z06AgENkDdUMFnkuZ4W8iPYWAmcBVuWRVp4gzagsF0SQp/UmVyv JSIk0lwQZwn5yZ/HZThxk1tuQ1qm5SHFdVwIalyjZaCvpVwNilsT8p6UwKDyiVwQylkKap+fcFq8 NaIH6qAmGp+3JTeKE6CVMJ2fXHWgMLpbqzWiEnIAedMhAxqjgZOgEApaPJqjPzqjd7MiLFoJDYCf 7EkhFHCeefMHkpWkUMogmCWEzJlgLsY5V8mcV4qlB1alILqlkDMZ/zWmZFqmZnqmaApfexAIADs= ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/logo-cancell.gif R0lGODlh4AFLAPcAAAAAAP///8zMzJmZmWZmZjMzM/z3/PHp97Kj29XN64J1saif2EtCsGhgvbq2 4j00q6yo3Kun2+Lh89zb8t7d8gIAmjIxpzw7rT49sENCsEVEsmhnwHBvxG9uw359yoyLz7Kx3wEA nAEAmgAAmQAAlwAAlQAAkgAAkQAAjgAAjQAAiwMDmQMDlQMDkAYFmQYGlgcHjwsKlQoKkA0MmRAQ nxAQmBMTnBUVnRYWmhgYnhwcnyAipiAgoSUloigopCsrpS0tpzAwqTIyrTExqDc3qz8/rkJCs0pK s09PuVhYuWZmzF5evGJiwGVlv2pqw2pqwHNzxXZ2xpmZ/3l5yHh4x3x8y3x8yH5/yYGBy4WFzY+P 0pWV05qa15mZ1Zyc1pub1aCg2JmZzKWl2qio26+v38zM/7S04Lq65Lm54r295L+/5b2948bG6MnJ 6c/P7NPT7djY793d8t3d8d/f8t7e8eTk9Onp9u/v+fX1+/n5/fv7/f39/gAFlQQJlSQnpKqr3MLD 5sfI6c3O6svN6m12xAseoHR+y7O54wAYnj5OtGp2twgdhgEiogYwlAs7qzNmzD1nsgFPsSVvvDZ5 vzNmmWaZzJnM/wBoxyl/xVGVzgCBwxWNyQSKxVq55HjE6dDs+QCMxgCMxQCJxQKPxwaMxg+UygCV ygCUyQCQyACSyACSxwCRxwCPxgOVygORxwSTyAeVyhCazBedzhyh0CKi0Cqm0i+n0jSq1Dqr1UCu 1kiz2U202VG221m53GC93mnA4XHC4XzJ5IfU8YLL5Z/X66/h88bo9Nnv9/L6/QCZywCXygCWyQGY zAGazAGayweZyz6w10Ox11W63Fu83WTA33XG4nnI4ojO5pHS6JfV6qTa7Knc7bDf77bi8b7k8d/y +OT0+fX7/fr9/vn8/QCfzQqlz0q73E/A387s9ej2+u34+wGn0GrL49Tv9vn9/vf9/uv9/wBmZgAz MzOZmTNmZmaZmZnMzMz///n///v///z+/pnMmcz/zP///v7+/v///yH5BAEAAP8ALAAAAADgAUsA AAj/AAMIHEiwoMGDCBMqXMiwocOHECNKnEixosWLGDNq3Mixo8ePIEOKHEmypMmTKFOqXMmypcuX MGPKnEmzps2bOHPq3Mmzp8+fFPfgkcBGzAcrH0BQyINwjztk6pCJA0q1qtWrWG3ieQNmA5EbLsKu mBGkA5o7AsWpQ8cNG7Beu3oF29YuXNa7ePPq3dvwzpknPkygOFGChOESJlKoiLFkULtsvGi1QkUZ FStWqWoBMza1H9/PoEPfvTdAgE5/gprYGExCxAjEL2bUmD3jhAo/mMixGqUsmTJTpk6lYhVK1Cxs yEQrX84cp7149EzfxOOlR4oTI0KIKFGiR5IrW7yA/1lgyBEiFHwurUsWPBatWrdu2aIVSxSrask9 e27Ov79/kfXEA509Nt0RxQsotBbCCCbc0AEbTA0EDzvlaBJJH4iIQo4s0mRjTDvffHOMMdr4Ikso wejjz38stugiQveUUYYlUtRoiYwC3UOPgAISGJNndzxxggkhaDfCCRaQYRA6uaxCzjrkXMKHI+Zw M05C3dyCyjYB7Pfil2AqN2MlZIYhhSVoWhLGmmWEwSOPPsKEBxQolFCkayhcIAhBnqFzCyvKKMMM OeREEsMhDLVjiy3phOnoo3m1+cgjldhzz0ExWjLPm3DCtMcWMdgpwqgoEPFGlwR9k0soyjTjDHvO /P/yQAMCrYhlLNhAquuuP4XxyCVKlNHQPfZQwml0LwWiAwqjVhDCCT0EYhAy1IBiSjLYJoMKMMhk kYMcDIXTCy7q8GruuTOVUcklj4QR0T0BvjnPpSzhsUQKImgXQgkz/IEqQdrAkkq2ybDCS7lo3CBG Q8TI4g26EEecUhm/PmIJRfHyWA9L/pgRgwkVOEvCCVREmOqq2TaDii3tCATHD1A0ZAwt12ykhhNG GFGFkgRx4QZBanBhUBXgCnSHFkgYwYQW4KpRxdNVCC0H1D8nxAUTRiBRxc9TQ11FAFMXFLTEZHtE 8aTuVuTmm3GidEcSKIww6rMXTGCQPti8ssyrzpz/Aos2e3hmBxFJeHmQZ9/c4otGTNCghRo300CQ HCMgQVAVIwhN0AhqCOQGDUiQEbTOAVSxA9RCqzFCFU7Q8LVBdwghBBdqkIF1AKp7jfsIBVVhRNnA Z3RPJZNWglHG8cyzEiA2iBqCCTGMYStB4OQCSrbMsOJLfgHYgUEReiTUjzjGALMJL+9gVAUNaA3U vkDrj1B06TRkvnnnd7heEFq+i817AGSQnEFytr/d+a93vwueAilCvEcECyP32FSnUKKHLGBnVCNA QRLscBBuwOIU2ULFLIzxrzscgQh4SIg+iiEJSEwiE+DACA00h5AZ7oAJA/Fd46oWAM4FQAs7QEj/ /4D2PzL8jyBukN9BVHfAyyVwgVB0iCUmZTGNPEdjKTHhCbQjAhP06yDhAAYrsqWMVeCHIHkAxBn2 kJB3dKIRClCEJD5xkSS+zyBcYB8XRtC+/u1QID5EghOEKATIqeFnqqudEHBYEC0IASGJNKQBnRjF SjKkgcbbiASTRy+TwIEHRHLNCY5Qh4OkAxeraEYynJEKWaBDIvgQRiQW0YhMNMoiTEzIIgWiv9L9 LnZCQIsPSXeQ9eXMCINUnRFosIM7wu+J/jvm73KZQ2ha8poDmeKkLraRKwpIOiZJwwtasx0WaAEh 6IjFtbDFCmokRyLw8MQL6dgQO3DwIJTjof9GwP/PEQhwiMC8gw+ZYLliWpOJd9jBIAuSR0geUSDU fCY2JzqQBj5CWBsRwI56hJIvmGBUXeQBGw7ij22AkBnJ8BuXDNeQ/cCjMywtCB7UEAUQ6JKRBmEC TgMwQ18O5HNI8KER50dJIkLUhwQRKA2NytRqUnSiZ6OURza5sZN44KOuMcER7lkQdwxjFdhyBits cYx/QaQf6sjGw2KKRCwk4QMSSMjnzmm0KqiBcp3LYRCH6Ln65ZUJQpjfzXzaVMDikQZ5BZvlIjpJ pz71mlHNJEcyVlWTPAGrDILC9AbSj3D8AhXZYsU0ykWRb0iDGAaZXh26sIQojHQhblhmzkYQWNP/ FQSvfBXIHhO7PiEYYQf6w1w/eUdNyr2OIGTYwQ6MIITK7W64kBsu54Tbz8dCUZvt8og353WSJYSS BCbIAkKQMQ1VYKuMKarIN3zBJT7VigwbcAIZIsTW20LOmbg8pEbcADnr+nchFk0bR7xZ2ZIk4bvh HS8vwMoeVdRMvew9iCCgsAQwcPW/GG5OgLWLxe4i2AOHQ8aCz6uKYWw2It+Yhja6tB87fOCtcMiw jPmz4Y54s20k2QBmSxCzgyBDGgxG71RK24sVeyYPYkgCB9qQhxPP+Ml8sahkN5IxHI9kCpg1QRPC Z5BwUGNgvlkFMOxC5BUHABBNSAIZ7mk4f/Sj/76la9pS4SeHrnnNrqXzGri48DQuvI92tz2ubqvm tDsTLWwDkQPOkDk/RPcssbjjWQ6JCmX/+IqKGNWkgJB1ki1g9gRJwG8AxmEN87JzexU5Ri+KcYAp IGELEnByANwM5x52DnNz5pydR8CEp3WO11ADV858xz6BLFOfEaVcQQvNhNU9TQ7U1MIInAA5J4yA rqrbaQCIKRDgFgSplf5PVC/KEY0KqMAlAUEJ5NbFIsThIPrIhqkLtotbTkTV20AAFNxgsoK8OQDH 6EZCfBi/pYLb1vcrCDGFQNdl0oCHEY0fUSOaS9XpM4mdUx0NdsptjRsc0uHmz7injJEbp2QQzf/T jgl4AAiEdKM3yVDZLcoqkT3o4Ri7IIYBUvhvg+wBHNmoxsMQQnClPXwgB086yBf+OmTKrn0RteFO Kf4/JGg7AATd3R5pyG2rMyGISAd5yDVMRXILT4LoLsngtridF3gBIceYxSlepYpYDB0idxADBHBu ZoToIx3aoMY17H2QomP96AgP++Yed99tM8FpStx2FQLa2DzeYY/vozogJT0QIxpw68Z+HV4pJ+mD j7059ii7gC/iTXCeBA9PQIGRTPCEFBpEHbtgxauUkQpsyBohdzDDEooQgW/oArUIScc2qEENEprV IIanvNI359uc/ey3zaWr5APwORxSc5c8Pa7/5hNv1Fz+kZhOAHvSFH/6/ozb7BYxdzysXBJ/jIEF JNDOCYgQY4OI4xqswAyqtArSQFoLgQdrwARBAAVzAHDRgHwFoQ7dQA1FNmTP9223lkABNX3sNxCk owU0UDTE1H0VJ10C1FiTtAPaNxBA1Fg7RDr5I11VY3rttxyXVjyZNhERdG4tQQdBsEX7EgNvdxDe EAsD0wynIAvOlxB7MAhO8ANJkFjtkAsQKBDjUD66MHgPYXh9FVSQxoEe2HQJxG17FFQCoVME0VMo mEu2VRCn01ixswNC8DVcAHYCYXWAJHY1qBwW5UA5GBHxknYokQdYEDekUgRxdXu8EAohVA35/yBX VOADGfAHXCYQU1iF6GAN0QAMLVMrDcGFfQWG5Bd6AkF62zcQe8Q7eHU5YDd+CYUE7XMHSBBMKBg7 qxMAbzgQqgMuNLiHovF+D/QugQgTb9ADshcCJNACWCBrxPBB2NJKS0gQcHAFPjAEWtA+09MOuIB8 xzAM0eALd5daA5eBDCWK0vU13NY4d8BtZ8g7bZhoPjR+AXAHzTZbTAB1D8V9rrOLbvg15+iLNlh2 2wQRGiUP9EB/KdEPe5AFCaJ/OGAG/hYA6aALoOAqyQAKu2CAAUABWTAEFoAFifhmK+IZ2rgN6XAN 0cAL2qAPBWEr4NAN36Acd9B4AKlAfVg8nf+UEAIQiK73EnWQASogN8/iAy3nXtwQC6jgDM1gCqNg DY9YBx9gAT9ABadyOAEADrjAC9OgC9lwSycmDtvwC8MQQzVZljQxPAJZKftgDwIgAPdAL/cgAPZQ D/RAD/XQky7xb4DAA8coAifwAxA5a/oxDtXACiCUDORQDsOwAAwABFAwCLXmDtgQC7dADDTnXgHg DdSgYulQa2b5mShRBkpQdhfDD/YwAPWQmqqpmmyJE/aHAycAUiagAx9gewORDryQCk9yCpFQCDtA CAnQbwLhJeNADNMADc9QDcPJWQLxDdUADcPQiaA5nTAhmpOiBAURl225nT2xB2KQA3GjcjH/gAQg Bw/nYCGIwAiRoAnmIJ23lw26kHPdMAu0IHAFgQzYcAu94A1kRp3+6RKieQmrlxV7kAZEQBhyQwIl kANL8AFeIAZg8AGJUAjqCQrk4AzPMAvV0A7u8A7i4A7hgA4oyQvE8A36AA62YBzYoA764A7qoA24 UJka+Z80uhLq8od3UQdTAEomwB0l0AIwIAMyEAM80AAOMAyzsAymECjL8AqzAA27wAu6EB+9YJIs GQDq0AuiYArPcAvSsAu0IAvUcAwWWKNmik2eoQdugAUa0AM3MAMzkANEwAResBQBgA/GMA2z8Aqu 8AqnwAqcQAqlgAvVYAzhMJJuFgDcIAuj/2AKqBCouMAN6dMPv3emlrpAelAHgWAGYjAGajABeMBG A6EPyOAN1+ALugAN0TANw9AN6VCmBOEO3ACmtcAL2AAOnnmpurqrvNqrvvqrwBqswjqsxFqsxnqs yCoa27mszNqszvqs0Bqt0jqt1BqtAjEA2Jqt2rqt3Nqt3vqt4Bqu4jqu5Fqu5nqu6Jqu6rqu7Nqu 7vqu8Bqv8jqv9Dqu1woA+Jqv+rqv/Nqv/vqvABuwAjuwBFuwBnuwCJuwCruwDNuwDvuwEBuxALAr AwAABXCxGJuxGruxHNuxHvuxIBuyIjuyJFuyJnuyKJuyKruyLNuyLvuyMEuxFguzNFuzNv97szib szq7szzbsy4rsz4btEI7tERbtEZ7tEgrEDOSJmgiLNrETQYhl/YwtZcytVabkwchAAKiPAYxAARQ AAPAEQCAl/casgHAs2dbsmm7s2vrsW17sm+LtEYbt3Jbt0ErENhVdjMykAfhTfMXAJsUD2RLEFqb PAZxsQQwAAXgEAIQtgsxtghRsR27tgEwsxdLt2aLsXFbuWpruTnLuR8LuigruqG7uHbLsXSLuRpL uqO7sap7unaLtwOJSTFSBvSytBh1RTuyMZwiHVIrHcQytVtbEF+btQXRlgOhuITruwMBuQchuag7 s6zruSMrutTLuiCLvTarvRnLvSLrvRr/O7HUC7vjC76XO74ne73oC7uxGwDaFAbWaTFPGwCjqbdX FC+FK0GmEbiWwimGSxDOm7wzG7YA8LWXWwD5KgADbMCQG8AFAb2rOxCLK8GmO8FvS8FnWxAVLMGc S8Ghu76aKxCXK8IjnLYZXMIWrLrmy8Gam8IlnMEirMHdS8IhHMMkjMEY3MIWjMInDMM2TMOTi74n vMMvvMGHS8RDzL5EK7tp6b7bdGmVcGlKcEX3Gw/1oL9UXMXJc0VcKxAKfLyQKwCLW8ACAQBhq7yV SwDEq8YOTBAQvLr5Wrn4msETi8D4Gr51LMLiO8d1HMd9XMcfXLpxbMdrO8cTjMBn68eG/xy9gszH 5yvHeTzIc1y5kIzHbQvJiQzIhozJY/zIdvzHE5vIlDzIley2QizKhGy6fEzJn8zJm5zISrzETkwp llC/aLJNDXQjVHRFhdsj+itB8wDMPZK/hBvKyQu22Dq2zgu2AYDGzuu1mtvGAhzE5/vIFgvEL7zH nTzGokvJABzIoWvC3wzAcrzN26y9K2zC0iu+1lzNE8zOEVzG0ezO3lzGoDvK1XzDllvO+MzNIDzP rnvHBQHP+KzPLzzK/xzLOMvEFxNVT5vLUcXLGSMA+huIVot2xEwQzHzMy1q50sHMzmwaCmwayivN ZcvI5wzPgHzAq7zO7WzN+grOHxvJ+v+ayf3czS4d0CEbyS9909Lbzy3syPT804RM0EZ9sTw91PcM zzLdvetc0+sMukkNyUKt0ELLxJRCmtuEXQ0UBrzsTYD7TVzclsK7tcPrxmbsxSMNwB99xu9M0hNc vCbdzCAcw1FtzAg8w/a8z3S8wx3swdTstnrswinM1Byc03AczrBMzhJ81O98yHqN00rdvEtd2I3t 11F92dis05xN2OSM19csznZt1UOL1VRUCXtbRXnrLrxcuBujvwHgt8ojQVzctTUNvWzc1gGgwGAb xhgr14P7xht7x5ZrscZ9x3hM3Bmr3J+c15/8z+abrxgb08/t3EjN3Nbt1CAr3ddN3NzLXdzTPbPI Hd7jbd3gHdPgXd3c3dzFTdXh3dTLvdzfzc7HXdziLd0JTdo1KxE4IhHc6cUNgbwDIeA6GbWD+8D5 rdDm67MLrt8xm+CJbbKX7eBWDbQUzrEQzrMZfuEru+HTjbLrzeHsa+EiXuImfuIoDrsySwAs3uIu /uIwHuMyPuM0XuM2fuM4nuM6vuM83uM+/uNAHuRCPuREXuTVeuRInuRKruRqveRO/uRQHuVSPuVU XuVWfuVYnuVa/uTJ2uVe/uVgHuZiPuYcERAAOw== ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/corrauth.gif R0lGODdhBwAJAPcAAAAAAIAAAACAAICAAAAAgIAAgACAgMDAwMDcwKbK8EAgAGAgAIAgAKAgAMAg AOAgAABAACBAAEBAAGBAAIBAAKBAAMBAAOBAAABgACBgAEBgAGBgAIBgAKBgAMBgAOBgAACAACCA AECAAGCAAICAAKCAAMCAAOCAAACgACCgAECgAGCgAICgAKCgAMCgAOCgAADAACDAAEDAAGDAAIDA AKDAAMDAAODAAADgACDgAEDgAGDgAIDgAKDgAMDgAODgAAAAQCAAQEAAQGAAQIAAQKAAQMAAQOAA QAAgQCAgQEAgQGAgQIAgQKAgQMAgQOAgQABAQCBAQEBAQGBAQIBAQKBAQMBAQOBAQABgQCBgQEBg QGBgQIBgQKBgQMBgQOBgQACAQCCAQECAQGCAQICAQKCAQMCAQOCAQACgQCCgQECgQGCgQICgQKCg QMCgQOCgQADAQCDAQEDAQGDAQIDAQKDAQMDAQODAQADgQCDgQEDgQGDgQIDgQKDgQMDgQODgQAAA gCAAgEAAgGAAgIAAgKAAgMAAgOAAgAAggCAggEAggGAggIAggKAggMAggOAggABAgCBAgEBAgGBA gIBAgKBAgMBAgOBAgABggCBggEBggGBggIBggKBggMBggOBggACAgCCAgECAgGCAgICAgKCAgMCA gOCAgACggCCggECggGCggICggKCggMCggOCggADAgCDAgEDAgGDAgIDAgKDAgMDAgODAgADggCDg gEDggGDggIDggKDggMDggODggAAAwCAAwEAAwGAAwIAAwKAAwMAAwOAAwAAgwCAgwEAgwGAgwIAg wKAgwMAgwOAgwABAwCBAwEBAwGBAwIBAwKBAwMBAwOBAwABgwCBgwEBgwGBgwIBgwKBgwMBgwOBg wACAwCCAwECAwGCAwICAwKCAwMCAwOCAwACgwCCgwECgwGCgwICgwKCgwMCgwOCgwADAwCDAwEDA wGDAwIDAwKDAwP/78KCgpICAgP8AAAD/AP//AAAA//8A/wD//////yH5BAAAAAAALAAAAAAHAAkA QAgoACGRGjgQkkCCpAT++8dv4cB/kCD+exgxYsGFEB9KnEhqYUSOHzMGBAA7 ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817685/bin/1475-2867-10-1-1.gif R0lGODlhZABxAPemAAAAAAICAisrKy0tLTIyMjU1NTo6OklJSVFRUVRUVFVVVVdXV15eXl9fX2Bg YGJiYmNjY2RkZGZmZmdnZ2hoaGlpaWpqamxsbG1tbW5ubnBwcHFxcXJycnNzc3R0dHV1dXZ2dnd3 d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/f4CAgIGBgYKCgoSEhIWFhYaGhoeHh4mJiYqKiouLi4yM jI2NjY6Ojo+Pj5CQkJGRkZKSkpOTk5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enqCg oKGhoaKioqOjo6SkpKWlpaampqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOz s7S0tLW1tba2tre3t7i4uLm5ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbG xsfHx8jIyMnJycrKysvLy8zMzM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ 2dra2tvb29zc3N3d3d7e3t/f3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs 7O3t7e7u7u/v7/Dw8PHx8fLy8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v// /wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAALAAAAABkAHEA AAj+AE0JHEiwoMGDCBMqXMiwocOHECNKnPgwE0VHgQQJ2kMxoaM8dDpSzIQgy8RATYaIadJGpEBE Azk5cjSQUSiXDRm5IDORUyafkgLhVBOoqFGjZG7iXNpQqEulB6EynSqJDk2CTqcWpCNI61REQTgV zOr1pdSyHQV9OEu2LKKzaCfScWGwrVdBcONGrCrJFKe/nOwuhREgAIDDAZ7onYhoiClHT5JwScKz rIvDmAEoXhwx1AZOoYzmEYwTRubDmzk/DGWibkGxBveISQiboOnTqVU7jFBbYFs6R4MLN8qx4O3M uXUvRJTcVNurEKEPPI65uXKEocKORXsZ9/WcD9j+oqWO+nvDFL2d49wD0/ZpzeYXOvqAyJEYMWq4 VBZplzz8+AmFQoMpoYjBRRtckAZRf+9ZB6BAobiQnoIMcfHBBhN8oGFIpvjn4IOhNDBhR0k08MCJ DTSghkAePohdCuJR1ESKNKrIYoMuRnWBRViRWKOJK5rSHXI5GhRKCTFONGOKD6QY5JDVFVkQIzQk KVETTTJpo5A4SjlQKJsJEkgeiFC4UIk/BtmilxBOcBMZQwTRxn5X1tjkk12yGQoMvYXm44+Vrann BW2ZqRCWJtKoZp5eRjgiRWjWuKh3bJpCB5LbyUgjinhSWilchiYUqaICQVlepQiFitCMTWbZKZH+ qBZkkZmM5JGHZHvk0ZcpJWbp5I2exipQEJYGQocaapBBBrKjBaKGG9BG20ZRWfDAQxDW8kBGUU1c 4O23CQo7EB214VVQXuIuNUQKODQRyBBu0MBDEjhUkYIpXARBBhc0VCFJCQI9EYQY1TbhBg558Kpv FUM8ocYTs6XriCBqICKJI3sARwdXbpiyBxd0PDFEFpJUIRCCZDyRRRMUM2KKGlmo0QQXTzjLY7o4 S6nUTEYKtIdUSmUyGkF0SMLIscXlTBAOjpCBSJADuaHGaENIx3IWmZBhMoRkGB1ye0obCZdS6UmV Xthop6322my37fbbcMct99x01213zowkDaD+C1tLuccGSbjIQxNsClLCh3cnrvjijDfu+OOQR64X IntkdLPkBrURRBZVJHE25gRmIjojlzO0h94jcTGZ6mq4XCQjn2eSFyOuH7TrQlwgPCe0jKi6GOkH CdLsUZUPR1xDbpiU6XeIiHEz8AaBJlHpCCXBg2toVaHhhQXl0QRU0OOUdyC1I0QHDo+WlQIB7Asg 1R40CELZE3RQ35EktycEUih7uNEGV76LiAvYRwD3EUQMJXiaG8QQPpw4In/mc8zDRoaRuKyvfQUR BBegA7upOMJ+BQFLbCxIQAMOJBB0aqBLHsgQOvTthBPhAQ1myAWEXLCAU3oAQTpIEUEo64f+VcjC D5XVlYJk4V7Lg4gBCPgBG5ZQKpkYUE1A2JASvOc9rTnXVTKBCJsEcCBLZF8TDzJADO4QB6FgBCK6 SEWGWPGKmUEiQQ4mkJTtqy1kICABoFaQMBJgjAa5oQl9BoM2DEENSXDD5xzyRjgeJosEyQIMBMKJ LvqJIHkkIJ0I4scNOLF9ZkuKGtnYkUY6EpJR40HphBIKwHBBj5sEIxM/iUOC7OECO2zjQkwJR1QK ZDKuccEGhqkAWCLEj4AMRRCzwIUHPJEgiKBLTRZZRUdiRo7jiliPaJACE5igAcY8CDK/dIFupuAA JSzIHiZQOxVChJdX9KVzpGiKlVDOFDT+cEEKUgBOAvKRk7Ok5Af2ec5nDsQRyhMIDycCz/dgUyB0 cMxLViQUbu7TmZo8ZkAJtAGCotOMNTFBKA4EMl0qpKGnkWdEXWPRb4bTIOOEUEf3+VECDEAqjEhg FdRQBXc+5APWPMxDTeGGF/oGnwTtJ/tiKZBOxqSj+qzpAAriCMJNsZRBBYA8xUCs7ViUny/t40Y5 MdOCglQgjphALrEa1KEeKybk40hLlUoAppoipn6ZqQlqOkhTMMKqCqUmQ0yQVXm2IaEeUw8OkhpW gIrxqR41KERxOU22WtOt9IQhN/WJ0aUSJBStDAVePWMCmqbTSPhzhE+NFYg2ojQz8sz+Aw1GNNeX imGYG7jAAMZaVr5KxRH+okwS6pcqN2Z1qIHoao9gwNiM1pGgKdjtY2WagqieNqSS0Aj5QGio12JG ntZDKyf6IpTFdpOu+yFDafcpXQJ4krrd5OuUPnNVpFZ3nwMlqD7BJhDvCjV4ED1W7wJxulzZamN5 KN5GCpwxOoBkeGM6na0ODJxAwMYR6KmsKSKgpRN52EQPQJ1/taqQB6ZHEi0RA+qIxogsrPiEG3SD YHK6Q9hEIEu++pGICysRQfAgEB9AbEGakIQkZLYgYrhAFXjQEoO4Qbl+5dEEctzhFO24rWiLq8Uc ceNEMQnHD2jDTGYiiQ1k9QNkfkjk/QIhiY4tpHwdccMexiuJTOAPf3a2c53vLLo66/nPft5znuss WHX27p4HYcQTBEGHJh9kg3sQU0csTAfSFTEhmfAXaEPxE59IRyuthFBC6MDpUEAQIi7AwQNwsAFt IgQREyhBCVJAgw/AYAM0cLVInOcR5aALEWdTCro6oroNwMAEG2DEA4IwAR5EwASAVU4g2jAaUl9n vI6QSV+eUEnV4s88dhbIqR/HhTmHQpGmeEIeMiEInwDGpHIT5q0V8AE6BOECiFi2AlTtggtcenGS +EsmPkigm+DZ1KYGncIXzvCGry0gADs= ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817685/bin/1475-2867-10-1-2.gif R0lGODlhZACFAPcAAAAAAQACCwAKBQALCwoKCgACFAACHAAKEwALHAATBQATCwAaBQ8WDwAVEgAU GAAcEgAfHBEREhMTGBMcExkbHAADIwADKwAKIgAJKgAEMwAEOwAJMwAKOwAUJAARKgAdIAASMgAV PAAcNQAbPxMTIhMcKxkZIxgaKhMUORkcNRgcOwAjAgEkCQAtBgIoCQAkEQEhHAMxCQA6BwE8CwAy FwA/ExknGQAkJAAmKgAsJAA0IwE0KgA7KQA1MwA6MhMmIhMhKBkrLRkiMhghOhkoPxkxOyMkJCEj KyMoKCwsLCIjOygqNCUwJzIyMjM1PDw8PAAFRAAESgAJQAAKSgIFUwEFWwAKUwAKXAAdTAAbVwAa WxkcRRgfTAIHcQEFeAAdYQAcbAArRgAsTAAiVhgiRBghVRghXhkjYzM1QQRBDABODwBBFwdWCghS CwlYDBNHHgFPJQBKLglhDABpGwF5Cwt7DQF2OwBDRUNDQ01NTU1NUE1NXU1WTVRVWF5eXk5NYl5e ZlprWmRkZGtra3Nzc3h+d319fQAKgQKHBguFDgGlDwGqCICAgIyMjJOTk5ubm6SkpKKlqqurq6Km sqKkuKuvt7S0tLW1uLy8vKKkwcTExMzMzNTU1N3d3ePj4+zs7PT09P7+/gAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAAIf4aU29mdHdh cmU6IE1pY3Jvc29mdCBPZmZpY2UALAAAAABkAIUAAAj+AEMJHEiwoMGDCBMqXMiwocOHECNKnEix osWLGDNq3MgRY6A3QCZIiECyJEkJKCOglECiRIkfTmLKnOmkicxLHXOG4vOAxQoAQIMKDQA0gFED FRwoMCIAaFMBTQM8NQpJ50BJmzDmkcqAgtCvQQMYCFDAQIIFQIpGBQD1KduqVkMRYqQVQBNHhAaB /UqAaAAEBxIYYcsWqlqoUuFa3eSpLgEkT54Q2Bu0aVGpgwUQLdxWc1PFcetSBrtAQVsARm08bTug c2HQoS3mGS20QIE1EARAeDHAKFPUbRMoSJCgM+zYFGfTvvzCgYAcM3oDGMz5gIMHaWQUR30cuUTl y7/+DifMtK0CEVl4KFq0oG137xDBj94MloCAzFAbjAAjJo6a4lTBJ9tyRtFXFFIDMCVVAg/0MMYX YbyQwAADGPCegA3JR5mBRRVQwQVpsZVAC3P0oIUWDbR2wAaRYJhceHuRZcABvwkwIh1riBDCAa0N oEGLLn5X32QEFhBAeQIMkIALLDwwnGcIXBhkQhoGcASMYgWQVgEHQBVYAgT0lmQAUk55kIYFKMEh WEaVxRQVVXgxRRcCuNFGInXg2UKZZhZU5ZUEFjhYBhbACYUAbbghRxoxtOECn30OpGEfT8BYVgAm GGEEEEccoSmnnRohhBGSROqQhoUkgWUGBXRogJH+ZFVggAEIVCAApKbKJwAiPiBgWYytGtVXm0Zq hoABFlRQgABAmrqQrnDcgUNQByywAGpAXQqrkajRJ0CtBgyAwCTOMqScBUZiYQcNTSVwgw4/BTWr WEa+GpZUAFRoAQIOkFuuQue2igAECaC2AA0iFFxUBmPNOy9QFWjQl4cWjNXsv2duuKwCXRbVLWrL FlCxURVYAACyyRaAwMUY+zmfbU5ROBTJGoxVls0WZFBBBRj427JBGn7FrWZG1UYUsrJWkIHOKFuA Qc8/Zxwjtvn6NfPJyqK8dLJIOe1z1JKyWbRTY98L8lgBlLy0Buh6WAHLYFdZdtqy0le0jFAwnCz+ CjmjSxaZYLt8L7dAHVBBra0ChXZZO0cRhaxKWKABq5fiGql8ZBHepqwGYFvgq0ZaYIFRR6i9c7Jw R4152UInnu2rR40FgCBLIKV0BhtQEjhBW9HWOWoPH4Vuh0AVgsQAIi8dRSa7h011m7LTN6ttrxqg s1+Ju9BbARuwvcHXgQdtm7JhGXlzBWSJjv5mCOzgQQEYaADFBhmAHzebFDvsd8mjx9r97xawghWe poEo5M1+UfuDgVYAgyjQC3Qe6MD5ulWBKhxCCkW5AQielgENaIADCPzZH9BGFARcgQOb+RsIPnCs AjGOA1bYQIEOwIEaLo0DGghhy/4wvrFoAAP+LegWUpC1AcO1BgFI/FDKToYBDkzBChzYQA11iDFA mOAEKlBBCkxgAxtQIAVDGEIWt1CGMAohCEUgghCEIEYVmMAEKdgCF8pwhjOUwQxkqERsstI8DAni EX0UkCDoEshCGvKQkfKEJjjRCU904hOI7AgmJCEJTUgCEpv4hOU6AopOgmJKm4AEKD7xiU6GwhIu AsUjNoEJSGAyFJL4pIAg0QiDoBJDoGgEJj7ByMZoApIC4oQoC3JLAamyEwX5pVU60QlZDmQTmrCl TkDRyIOAwhHRJIgyrdKYgmyilsRcZkI4AcxnljMnyCyIJ45TKp2k0yCgYAQfB7JNjXiyk5z+uKdA NtFOgmBCnAhxxDsFUs+MOIIySBAIJhyxiYYyBhT9zIgTCEDRilK0mwKRBCeS6UyDUiYJAvkEPy2p UVBskiGq2gtGQ/GIjTbSl+fEyEH3AtJQaMIRBokoRlIKFoyCwhKf0MQjILFRR3RUph9VKE7DuRGe fmWljIjmKCFZUKTuJaE2JURMi5kRpwplpY3YqDZjepGZgqWmrJRmUymz0qEmk6wWMetX0HocrmKk CWwdyDHfKpGgwlWuQsHqN9WqEa8GZaVY4ehEBkoQwAalppyw6yk5YligrJShfNUrYxjC2IE4FiiQ NURDMYEJcgIyIp7I5EEqCwCwZpOeMe3+7EFW2tik2tQSqSXtRnWaEFW68hGOcKUrCcJaxHoitZvY aFVlGwpPNOK5jWAEdBuB0c8CoKaSWKo/HfKJQhiCEYz4rniJm9eBNGKRlMzKIyDZUE6wMrnJxagn wgte8H6XEdVFqEDcS9iFfEK89bUveVVKEKLydZGcSLCCEzyQTgQ4wIZ4p3Vr2sr+KuQThLgvfcM7 4J4WmLbKLO2CF9xgDds3vPml6X7ryl3vPtgQhujwUwkiT76KeMQMFoiDN1xfQ6T4rPs0xFHtmtqj huK/MD4xhwdS3MaKlZ6fRDCOn7zjHtv3x18RrHYHgkpOkPbLpNXEa7tr4vDGmMnlzSj+bJQpZRw3 2L5llrBtJXFagnR5yvwNaSEgLOCB4JXAnn0tQSF5Yzfr2MQaxnJgD+LeTzTCEpB4hKQnLWlHWOLS kRjEIPLC6U1f+tJ4QEISRD3qUVMSkqAQBIijjGcqPzjAin7sQao5peOGYpTqlQQmGhFpSUe612GG hB+GTWxiQyLMetmLEUgLEdrGRaS3vqcnPSHtaneS2taWdin12ZBQ8pYgCV4kQjrBCUmAcyImLYSR CQLRRqxbIBC1RI4hktwnH4TOnrC3NklaEVBcAq7sxsq7bw0JW+sE4HqNJEVc6QdGEEISCA/NJhzx XOluWUCThASdyVlrjdNZEydVuMj+R07ykjMEE3U2OUYgYVSVu/zlMI+5zJ+Z3G2nUtfMHHhsPiFP Xcv7E98ODUQ1ukhPSBY5mhT0ZHEZ1kd+8ug7Z8RWUxlWOwfpmv+0Oi4tkXWBQD02zeTEcZ9+cNXC 0xID/XpcQGEITmiCn4wMOkUkYQm6P4KSly7IebV+EVCIWecEoa7YS7n0jICCMgQoCFagScqQW3OU D3kEbdUekcPvJQIFkTwzqS33yuu7t1XnO0YsDxbM6zWqor+IsxECCrNzeSOk/4rpB0Lt1Ftk9Qhh hJd1LXbHsx7xBWEEVynfkEs81xDP1awmjgoKQpAzwZAk/kNiL5TZC6SltpeIIZr+wH3u6zXnBtE4 Uw1PJNnrHaeylP5Ctt/9JhCU4oxwRETjOXnYU8b6EHV7fH1PkEK03/2h0Ag1wX2CQEz6pn4NQX1B YX2wRE6eEH0YwX7c5wQC0QjtV4A05l7QdFydV3n3p3iChoAJIYHeF4AXGHyMxErNJIICkW9GpoBA wYCM0HWFVxEkCIAW2H0YeBX1JxGyBYMAkHj+ZG8saFOCdoMVeIIZOH4LAQrH1Uia8FLlBIQMqEvZ p1nwNFBIaII6WBCOcIAOsQniBWNJpl1UWBCv1Ew1SBCpZUnJ9UmOgAdyKIeQtIWOoIRXAUmMRHbd xmP1VWdAKITm9U9F9x532H7+kMQI3ZcETfBJW5iDBBh8yER3cReGGqZhZviB4NZRljBKqUVKAnGI 3dcYioiIofCIeCgQPgZvXsdujHQQm2Bl9JVymjgQomVnkPB/RfV/pPh/ddh+FBgKotgEOygQkGBX XSZmrCRmYvZksVhm8adXtWiMRJiL3ecEu2iKkMh9jvh/SdiFgadv/1RvU/ZMYxhggDiNAQgadfd/ yDSMTdCLpoiK4NiCfgBMwFQqreaMrwZj6bgXgphRw2eN3ZeN3ZeIvniK3siFTZAExdhcwBRfd6dx rnRJlORKn0ZL0wVdlnZpkuAHgiAIIDmSg3BpssRsm9BIjFAIRoAEmmIEdze9CC7pkkZwjH4wky5J d37wkkiABJcmCD3pknnQibP1boRnFc23UWLXPJWkdAVRbp13ap/XhNZUlfB0EBGnEGgXcbqlEAXn hBAhVLSFCVJXEGRJW49wZo1VCAqnhgXhdG9pZPlkEHOZE5jASgk2TzPHEEBHCNFlCC3nHeRGThrF GPyXESk5eFNpFaTUSZnEGHq5l5KJmNlFS48gb5Dwdm8XZnc3maHwTRonT8klCTN4mYZAZ49Ag545 TqsZGwEBADs= ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817685/bin/1475-2867-10-1-3.gif R0lGODlhZACFAPfHACsrKzIyMjMzMzQ0NDU1NTY2Njg4ODs7Oz09PT4+PkBAQEJCQkREREVFRUZG RkdHR0hISElJSUpKSktLS0xMTE1NTU5OTk9PT1BQUFFRUVJSUlNTU1RUVFVVVVZWVldXV1hYWFlZ WVpaWltbW1xcXF1dXV5eXl9fX2BgYGFhYWJiYmNjY2RkZGVlZWZmZmdnZ2hoaGlpaWpqamtra2xs bG1tbW5ubm9vb3BwcHFxcXJycnNzc3R0dHV1dXZ2dnd3d3h4eHl5eXp6ent7e3x8fH19fX5+fn9/ f4CAgIGBgYKCgoODg4SEhIWFhYaGhoeHh4iIiImJiYqKiouLi4yMjI2NjY6Ojo+Pj5CQkJGRkZKS kpOTk5SUlJWVlZaWlpeXl5iYmJmZmZqampubm5ycnJ2dnZ6enp+fn6CgoKGhoaKioqOjo6SkpKWl paampqenp6ioqKmpqaqqqqurq6ysrK2tra6urq+vr7CwsLGxsbKysrOzs7S0tLW1tba2tre3t7i4 uLm5ubq6uru7u7y8vL29vb6+vr+/v8DAwMHBwcLCwsPDw8TExMXFxcbGxsfHx8jIyMnJycrKysvL y8zMzM3Nzc7Ozs/Pz9DQ0NHR0dLS0tPT09TU1NXV1dbW1tfX19jY2NnZ2dra2tvb29zc3N3d3d7e 3t/f3+Dg4OHh4eLi4uPj4+Tk5OXl5ebm5ufn5+jo6Onp6erq6uvr6+zs7O3t7e7u7u/v7/Dw8PHx 8fLy8vPz8/T09PX19fb29vf39/j4+Pn5+fr6+vv7+/z8/P39/f7+/v///wAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAAAAIf4aU29mdHdh cmU6IE1pY3Jvc29mdCBPZmZpY2UALAAAAABkAIUAAAj+AI8JHEiwoMGDCBMqXMiwocOHECNKnEix osWLGDNq3Mixo8ePIEOKHEmy5J84JSeuSjlwhwyWENfE4QVTli2YDzVZoYmzp8+Hujwt+tnw1Bov dfIkzaOUqdOndQ5pWlRoaVOmfSwZ/DWmUKE+CD2tFHjzVyiyAk+BtLQhAIIgcOPKhWskyBqmh/IU YrOkrl8jS+oc1DXqGMpjQb1ooilGzBoofSTlGbNEDJsxULKsASmpRIcNIUqIHj0aRQkUKOKMYVJ3 yZo1NEyjRsFijMLDBkdRlTTq1Cihlg4JX3QI5KIQGy5sWN7hc/LlGzqUYFGHCYoLHWjIGBOkOXMU Ym7+95TF8PgF5cqTn1+ePjn3DhIQhOARZwn06CW8iD9YR1OoVafwckofo6wySiin/HcWRL/wUB5y 7Kl33oTpXVCfDDR0wAIUXqBw3wb57RdUEJ7QlAcTdSwhVYpiMFFVHH8YIZhDv5wiyYIKmUfhjhRu sEAQLe6wgxVsyHAfdiEKZMlYtvxhGEK62OKJLbrw8l+BQVFpCRsNaXWIbVottEgJEvLY4wYSBDFG HWNYwcNn6C0XIi+F+JYWFH9s1tAvFrFhiSw28cBTQmMmJwGFh15waKLp0bBDB/V1sB50IeinyyI3 DUQTbrrIwgufh/h5TBaLeLEGZlAUtYomrOZxjC3+hYQSZo4hKCrBrbfamuuE0DXXAYTtgabfMWMV dBgvo/xxCp9jiLGIJ3uNkYcubTIkSRbkCaTJMX+4OiihkkrwwAO3jotrooc+92GFyiXJyyG6GOuR J6fES5AtOJYn6bj8kpvruYryqu6HSVJViLwc/WmQJ5JAtAh84y5g7gUs2BowrgFL+JxylQo0Sh9q EYRbRpZkWhAT3+orrsT+diDDmQDvGKGwA9l7jCxgjWyRLId8ywurmsz40HHimrtrj4hiHOdzSRrm iUCeiFGInhORFwqrcRRriRU4FuZwrYfW+oCZ6yEaMK/tDiuLJE6KTJEtPCxmkCYhV/RwCVY01uL+ 2EdCV/a/ZS/XMdTFCqSzQ/4VdBMvi6Q80XF1WCGDDEBaIcG6fpeJtpzDHjPGUARxCZEuktg8EL3b ZnRIEFmwsAEKMhBJ5oeZsyez4MOuIkbDmloBUR1PH2RFcRodsgR30wVhRRxifOZrdL56F930zIGY OxSgD8SEQ7JmTxAvkniPkST0eSEDE1bkscZs7KMQAguohfDAabKJ1pwM4QkEBfHH1CFLEAjhk0Bk 5TiBrOoYBayIJ5iApz/0oQ5i8AIUlrAEJlTQPgf4DAE2QAAZEGABbVmABABALqGxASzHOAUbHoaQ LGiiD1lI4C884bWO2II4hQhfIQ5BHB7yEIf+fzhEIf7whx0S8StE7MMQceQ4JuRrDZLQxMF+IcMO mKwjv7CFLFbBxS0CiotgBNApfDNGMo7ijGg8Y6ZWYYS2DYQGxTmFJTRhOoPYSxaz+ggvoLChPhSx iEPsVh+cUoc4xKEOhYwDG17DhkUusg68O8Ya+CcQFBhBE1dMyLY8ka+P6GINPOCBTAy5BjYo8jVj OJXevMBKK1gBCrCEJQOlJhBZqKggrjzISk5ByalkUo+F8EIWrJDKMXhBDM0SJiuzwExXytKCQaAB XHZgBCu4cQ0HExkAF3aMvQBNEyxICZ3WIIYsNKsxy2QmFNAHhVeukwnQ5EEQeOAoHkBGIEL+9Jou 2CAJNuxAE2PxmidkUUOoifMPbTqmF5ggTA5lwQvuXGcsLViXUGrHUfc8RkFtEYd9ruEUeJyKtiI5 EJKKRBcItUIWIshKYQ5zmK+Ep0xZM08h2XQHTHBVQuJgCzkKxAqF0ISDtpISlLLhoeVkZjNd6U4K wpOCdaGBVG+a0/0cQxKrOASf3OgTo7oUlkt15jsBY4S61FQ7GHIUE1CIkJGp0KBEMWoEYapUd8aU gkEoa00nl1YMVXWnBTmEJYRCFMTsZa44XUIzJwrVvOaVBzuYqlT9qlM7PuleCISCJgTYE178gQ1i yAxTYypRikZVnvSUqmpZIIPAHMQTdSj+xA4MSVvaWmYHLCCrBb0wBlLWdpS0BW4cRikT4dZ2JgJB KWV4wASYRrSCrNmBY6cZWak+gK+uNQisuMUQrhIkW9zSBWezSJBV/IEXNwFvQRZhL+VKcAdLeOUr +0LBvlQULpCNbGQnx9ogVFa7Jl3YgRQyCknk0SCn0AQlX5tNXfShnGKgL3xj+c6+yDMukFWtDFjb 2v8WxBLiM8giFhFggoxihQqRhRc8XBBNeCEO5NFFHBhY1/hagYHtpKh0HXtT7bCAtdk9SI0Wwgtd FC43vVGIkTtpxwXpgk3CHK1EAbPOJdDFrCwQ0mR/LAMZeYSg4x0UZyuC0jhAFKbtdOb+jctq33kG occb/rGXPbKIUq5hFJbwwl68cmCJeFWpS8hMFtJM0SXQoKyhDGV145zbw2VEFprAc1AOAa3BFnQi Dj6KMuPbzCBY0L47uLCjbOpj2AXB0YVtiINBq7dAZwF9cKEvVMtqhFDOM7WTm7NHdliHIIbYIrp4 USob2ayVRjmpwwwCC6TJ2jTJYDolwB9IWsQCK6BAaBnhRXC+4hWvJHGQfXggU14dAiNId3JL2IGH YmMbT6KXimMWCZ/mLcBfjPcY9EZMqvfNb5FYQjI71AR5eIGsUXzKFlQaRbwSnM1+Z0Q151YiL5yq vD7sYBFQwKkXTjGGLDhcI+itV5X+4kWlIo9cF1FaFRXr+PGWu/zlMI+5zGdO85rbHCR56PNINCGG BBKl47/2d8db7oksMHkkujv6zZfO9KY7XSOyMjDQ5qgJqhfoat/UhCc8ofWub/0/8a55FhZwgRDM FJ5EsgpdlarMh7Z0DedtOhNKcB7a/PjHNGADD2SQBTZkPNSovXBcqNzRg8jiFEd2eBA8E70QOJ5y MphPHaAAu7RK9qY8cM0vjxGZP3SuIEU22U1WIUCebB4ji3cOc5oTghtDoUWo4bJqp2rTIGje8GPE DS8JlEJh9iEOXG/TGD4HSwd+JAghaE4JHJ98x5fALl4wgmjsbvlR4zSva2C52wb+QsVaeqIrWxdK EHkYW8F+xAjNR83yQzN9Lv/Y7qylvXRDeTztDwTbLDn9QBbffNLQz+7SZQQbNoCqJSSJ5hr2ZzgI YQv+UWQItAqhUCW/YGQEF3YLYUsLwX/MN33UJwPzt198lVY3ZXtroH+XlUKTURin4AVBUAdscAhx YAVL8GJGYAlLwAZ1wFYMISACtxBL8GyhIRvUxwNSIwZGMHsaFmpMcIDZRxB1c0aoVmRRBChcFwqL IAtcB1BrEHTfpRZGcGkIcYSwUwJMAD98ZQR58AdioERHiIT6lWiexgb2Ygt5cEYCcRI7UBLmBWKI gQI+yAL/R30sEARqyEChUl3+syckrCFPTCCH2tJwN8NRBSFAumAJa0BQoaIJa5AFkkA1CTEKWcQq fxBJlmCBBPGDs3F3MhBKaFhIa6AJY1BdiCgktSZPCDgQiad7VFEYo6BnhaA+fcAGK+YF3iU8lhAy EJhcSneKccZolteIOZgF0aRl1Jho9FeCmpJJqIYY84ZA3WiKA/EsjmMJOmcQP+h+HMZX0iSN+tWO 1pdfmdeEAjF8V7SNdmOKbJB4B8EEfMVad8dh8ndTAhlqBnh7AvF7Y2aPEvELXLgKVgCOBMGPXNaP 6ugowjSQBgh49OeItUQQoTAK+GcRpxB0PxMKJbaPIfiP8Ychp8YmBIl5Ghn+hzazCnkgQHkQB3lI ERNILKxiBOVlb6HwffnjEFCAVuk4OYkYW17AA66EedYok6dzCGNBcAqpEJ5wSb+kCzxAaRCZEBmn YRhieTbFA7WIXwYIh3DRiDbDS/VIEZYwCuolENoWCrLQlQohjdZ4lrbmZqHWFzswH3SRV7WmPHVg MyBpOhz5EGsTdougdRmBKhQWS2omOQgQHRcwLihQmReAAB2QQR2AAH1gM33ABKbjBSZYELxUNwTh CX6oEX9QSLCJSLKpFDnogrRlSopkSKbUSEkhCZx1CF6QkMHDEJ4QB0yGZz4Hc5LABJnCgHGQOlZp CSkDPiXjETaCVQACIL3+cSBldEZByXVbxyrkOJ5zVFBsky2H+GuhkAdC5ZsHAYsg4QkskG5fx3X/ JgkGBmJxkAdK5G2EJJs56J4C8QsHJgbeJRVKdAxKhyAhIUd8xirhQxy+JkTgNkhsskinkkrIxAaF 8JtZYDrGJAu6UHVVxxBJFhKjwCpZIQnCMUSx1W05xRSNhKHnhE5ewAZchXH1aARQsIy5oZofIUf/ RmIjRkQO9ItrEJuFdBmrxFKmwlUnYTrMM5QMYScjYYUs+hVA1G0ItSaIdEqr5FIPhU2ctQhjUI9f UZ0LsTwlgWcUOn7eJm5EckikNHwttVCuNgZc5RUCFAqHIAahQBNyJF7+ByErtpCcG2EjQhQVQuQV jRRuSnGbi5RMyySD5vQHnIVVAyEcTDAKWdCnrSkQzyKdMKEblwF3h0REaehAtomhGcpSrwRTeroQ h/GW2pI6urADp/kRKZonN/qLSgQjCCWMx/QaquRS8ANRTAB3EIkbtiAJzyoLowqGJWEji3CTLooU DhRuRyVMzQIFyaROzeVKs6oQ+BcK4TE1RKEbvZYHkNEsTIFINxl9QdBOK4VOdUWumGpVA5EHi7AK cVmqIOZHOSgtg5QHl2FPOyAGr3SnzhVLY9AHzYoQQ+QJbMAq9LKrGuGmhWAFD9RrbCIGiLRILKhY TopmE8RQEosQh/D+B0xgYDD7b/d5n/hZCMyESqtxKq+hGWsyXEq0CEMaPuRIYjQrs17DsZ+1BoO0 n5YRss1zTA+lVM9kZVlQkwjxb2KARr5xRmO0nXlwCGbEtV3bG1m7tWZ7RlznLGe0CFqbRnqCZ1TR B8QkSKpxSOHaca42aIVGQVkQkgURCqepcgpxIyZIQ0A6iaFwFlYoRB67rU5xSI1EThF0YzFlWoDR txCJnwsRRNB5EEV0klCzO7fxsgrKQy/iR9u6JpOhSMMHq3d1hNQEBWwAkYC7ELZQigoRVCaodYf7 t4q7bb0Wp8FITn2rSnMlVjQFF0TidFY4RN42RPxZSn0XuTcWZRLFRZZxIbt2ORFRkYZ1ACs3uQhB dBEmuUNf620OdJNMIQZmhkx2OkxLyAQ0kHnmtL0SMUYGxl7kB3w6OBFRB7PhE6Ew6BXhlqSR1yEv gwJMgB0h8GxWy3RaNEZghHhbS0MHgnW9VQi9BbnkZASXQa1PN3NpOAY4+AcBG8ISIY34MyQaazeF 4Bhr8ge3u56HUDrhEwp1MFi6oD4o7LnxlRkiawuLFBhLUHTh9npQYAtr4Ds9jBEg3MRQHMVSPMVU XMVWfMUPERAAOw== ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817685/bin/1475-2867-10-1-4.gif R0lGODlhZABgAPcAACddf19fX0hISGxsbGNjY3V1dXt7e3d3fWhzbyg8zjpxiDdKzjdd5iZO43lE unt8jE5o2FRu10hr60py6VNs5Fd86Wd62Gt76BKcKA2kIw6pJBOoKBi0Kh60MSu2Oy+3PDG3Qz7K Q1ezXknCU1nKWUXHSFrOaGbNZnfXeWrRdXGAgGOQoXaK23qR2GaF6m+R63qH63eX633YgJEcs5A1 rKA8vakbyLIbxrgcy7Up07c21awozoF6h6ZVwZBe5MIr1MNJ1shS4shz3cpn4tZ65tBu5IKAd4Td fYOEhIyLjIiFiouLlYiLmI+QkJOMlZSUlJKVnZubnJSZlJqZpZGavp67jp6ipJ6jqaGdnaWdpqiE uaOknKSkpKOjq6aqrKysrKmmpaWmsaass62rtKapvKyxuLCurbKstLKzrbO0tLS0vLa5u7q2vLu7 vLm2toab2Y+KxoSa7IiN642h2pWn3Y2k6Zav6p668JKu6qWc7Ke2x6a63r28wra4xb2806Wowqa4 6LG/6Kqy7IXaiIPig5njm5flj7/Av63NqqbmpqnmtLXpsb/AxL3CzLrD2q/A5q3F8bXE5r3M8bPF 8bzR8r7swcS+vsG/t8S7r9iK5tyV6sK/w8m9yNS23M2+0tGs7OOt7OWg6ui57cXCu8PDxMXFysbI xMbJzsvFxcrHy8rKxcvLzM3N0s3P2cjK1M3Tzc7S1MrV2dLNzNHJx9LO09TSztrXztPT1NPU2tTa 1dbZ2trV1NnW2tva1tvb3MLR48ra6Mza88XU89Lb49zc4tfa5tPd89DP4sfsydHvzt3j39rz3M7q 0d7h49rk7Nfg4tvk9N3o9Nfl8+Pc1OHe3ejF7e3M8uDe4ena7OnY8vLc9ePg1uTi3Ojk2+D02uTj 5OXl6ebo5+bp6+rl5enm6evp5Ovr6+Hl8+Ts9Ozu8ujv+OP04+n15ez07O757u3y9ezz+vPs5vLu 7PPk9fPs9PTy7fj27PH57/P09PT1+fT69Pb5+vj29vj0+fn69f7+/iH5BAAAAAAALAAAAABkAGAA AAj+AP8JHEiwoMGDCBMqXMiwocOHECNKnEixokWB4i5q/Hfry0aNBaJ8rPiFwEiLBpSUOykxFReE 8cyZK0dT3Lhx4Ih9A9eMZ7NvO8GFC1dOnLhy5r6VA8c0HDhz5MANvHVoID6ZMo3m9EVs1bdd3Lj5 Gjvs2jWgPJ3xFCfTF7+JuHC9w/duLr5++fLm27d3H1+/gPP5+6evsL/Bb/3t89cGoSyWAonVg8it 1z9+3xqaodWq87HOsWLBCh0rl2lYvnDxIkZsTEGx/zJD/vYOojlGjFZda1jKYmOC+UitcgP5Hzh5 EX09U+Or4SrfBomlwwK5Xzl6E9c0Z/i84u+C/lz+L7x1a9euW7ZS+7pVq317WvDbMJ24i5fAfuD/ 7RPYneL3gmcwxI1A+hDmjz7esOOOPu4QNtAq5kglkTi35PMPfv30M48ooYhiDX7P7TfRfwTZN5CI Be32Dzv3eJNMMokkaNhgAt1ijooO4YPcM43888489FiTSRFBEAEKdv/0N2JB+KyEC0O+rMPOMoug QAIKR1RSiDfLNDjYPqvIs51D4IRxSzl85INNJkLokIMORXw4UG8V8cEkKbs8dqJ++/mFzyvsIJNC CBx0UMIRhiSCzD1fDhamiQ/dcooSWggBxA034JBDJtpgKFAqFpFikC7NLMEnPxb6JRA02IiRCAn+ HMRaKAmIeiPQPQPRks+TDb2jkkBr0IBppkBogl9BdFIk6kBZbOcRYPuhA080xuQhCBMndKBBBhlo sEEJKCSyjqoP9nPLQ4yYI9AzNOSAww9E0HNsQcsihI8q04i1DSqj1CaQnQP5MmA/bcADT1/5RENJ HHHIcYECHXSrgQYcbEBCFYio0g03s6j7Dy37nNuQOWYK5IsDPvjwCYoG1XvQKksowcQpYTwABaT/ tSFyG/kcDI800uDhggtyVAABABgkza0HH4iAgApMlDJFF92dS4tD5iihpy9w5BHJOeS2zBCKLP8D sEBggPpPHwZHEwwlE0ggQQwxuCCBAhhksIH+BxyYEMIJiv5DY679XD1yEmakMc4/fgTjb0IkRvRf FmO0YQ4v/kh7RwwSuPDCC3FUcLcHIIwwQgcogCBDM+scBKqSC9W2yhdKkIHOO2UXdPZEjBg0SxsP oArNHXXE8HkMm8ewggkpKCIDCIWMoEiBroMZ0WCp/IEOOhYm5LJEuxP0Us+QQIKHJJAEI0ww0uiB zDrtKIJCJYsskzt//ogc0Sp9NNR7nQhRQ5/8Eg1V7YMf+7CPP96hD2ZcQQrhMAMYVuGLVBziFmkg hZ1g5xBucPAg34tIsgoSOYNASiCkSIIKniAFM7ThhQPIghFe8kGGfINXCwkhRNRmkPAdhBj+5KEF ecizi1rIYhWzWAUrUrEKJvaDFRD5xrLGpBAdliIVbUiDKdYQjn98wRerMMV2eCiQcKTCH1Q8ieEe 4oszcKKGJDzIIdDQBCUMIApZkEcSkmAAKRhAICOskRm2UJwkRSQd5LhECQ3CCFwMcYi5qAUscrEL WhRRFudxJCxq8ZKC7GUKhYSjQnghSoug6H8GWaRGSokQXiTrMP7ohz/4AUt72PKW8cilLrtRjpt8 oxsb48Y2tjENMCCED7o0xzg2NsxpTMM8RSxiEmeRxFY0MRWjGAUmUDELTpDxIfvgwhea4AQe8IAV rMhCK67ghSVA4QBRuIUaVtGFLoxhCk7+WAIuhlGGPjQiDGKAwgCe8Y0+SMgg9OgDGaAAhSwUoxWu 4IQfyLBQgxUjLpwoRRgGwxqgoMIJ2GnGRjCjioPgQyQGsYcqvvkPfGDwIf7YBQ4Fkr9TMIka38RH LXxYkVJE4aBWgYL+CLKGNByEFl54i0PkqdSB8EINBpFHG5oqEHyoYV4bud8/zLGLVfBDFv7gBT/S WJxdWGIcsijHJepB1kImZBVtUMItuuAEKKiBBxlx6z9SMQZSsGEKYFiDDvW6kC4S1qSHTaxiC8my x4GHqizpiDl8YYpVRMEN7+DCWCg7VMjgAwxJSEUangCGAGwhg2v4QhRG+4QmfKGzG3n+BwG+8IQo JEEJSLBtSgbwhAF0spD4eIIFSZGGDL6QCxlEgkvQIE7YHrati42udKdL3epa97rYza52t8vd7nr3 uxehzXWToMropmEA0E0sPgpQ3sUawAADsm448KFdfKQXvNQdXEHMwZa6wKM2h8GHPuxRD3m8Yybx GMc1RCqRcNwEHN+IClN6iZOcjGMoOLkwU8BRFKik48PvMFg++oGj/fIiLsqwxYlLYwuZtuIVr9gF a56hDG5goxjOEEc6RLwYgTQDSRApcSGhe8KGlGMLphhFEsBgBOf+YxztgEgvxpHXhLwjFUOkRVyE KAtUYOGFTgDsEx55C1wEUiCHsIz+QvZDo37IgxHNaAYjbKGKbcSkHMJ85i1I4bGH8IGnBJFHnw3y DTXgwhdjYMQpzizkGl1BIbdYxSpgIelVtOIWrziFpXERi2EMoxnnOIe08vGNQTuEpUyqMkUMaxCb JsTJWDN1Q3SxkKtcBKgEofWrLcJfiRBjIfyQ0GL6oQ16yAvICmF1QWD9j/sy5B2LS05CEJgPcQiG 2KAQhYc61RDZgOcW+i2IsxciD283xMEHLdt+MPOOamQiE0EoQiasMQ8yybEW+iEIPPSDD1rfZSLv MHdD2gDVfP8FVSM+RycyoYOG62AIR3pIo//RC1PxSSD5oAs6aJGhefADqw3Rh7L+F9IPdZXiLQP0 BzzwgY5JxKEGNoj5DoZQjXo/5NcF8apRabqPdIhjGJH4xSmwQY5+QLYhwX4IOM61iv0YjOXnMEYg BMGABszABg/XhDYkQtbe2XQv6XCGIwDBgjnQgQqdkLXSJX4uYvAjGuiQRjCkbocKNKABDOhBJkIx j+5FpMj/AIM+VuGPdAD9DRZYAARYsAcxzGMe/aBvg9kIKrf/42DSmEQMLsCAoUnCE5APG2UMEoV8 rKIdv9hDCxaQgAi0YA6P0AM+/n0haTvkG2kwx45nTy3ixQAPk5DGOWY6EZwTFQ2+GEYxYLCABVjA AnTYAzAaEfmj3z4iYyh4z6D+QYlJBGN7BwO87ZedBEfMwQKLtwMdIkEJZ5gilgXRjuIyswZYPAMM aRR4Q0C1mH3gIx1wdzt8MSYg5xDGVxBq4AzAAAjAAAyx8AiR4Az9wAwH8QS31UfXsAVS0AQGMABU pX/cIRAish9+12wXAV2uMBi4Q4Iisgtsxmb6cCAxqCPywA7lABTfsA2+wAu5MG6EBiUIwQVcIFdf kApfcAhrUABu0FTi9w+6oFX/0A6aFkaVVgqlsApxcQy64AzZAHfwABj80IQKAYLihhCHUApSkAaq 8A6HkAZbIIRV1oS5YH0f4YMDYROO1UoneBBtQIYfwWwH0VcMwUS3QGmVtgr+snBpkgYLtwAf8NEK jHgLPOULSkA9xQGIB3FmkHGABNFeexgRa+RW0KULdGgQ4UYYLDMYs7QYxOcc5nFiq/BInIELlHZo xFAMuqAL6zELsqATsmALtzALprAJfJALsGAKqPYPynCFptAGaCBpjKAKpfAFbgAGXFAKpuAGbrAG a2AFXNAGq1B/aqAGZfAFVrAejCB5EJEPEYILz7AJ6hKP6WAOxLAel6EjdQFtdIIPFnJg5qALmXGK BDEXM3ELlkFf/GAO+pAOXzBAIiIPOvQF6ngRsgCC4aCJ/5AGAtkGebgQahBfBMEPZpBvuaZqA6En sYUQB7RVuBAOaqdXnGSjCiiZXa6EhNL1j6bwDPi1k3pVijy5EXtWAN9gjVwgANP4Qqm1WkhAWh2p EWvABeSRBmCgBE3ADwXQVWnQBsakV77ABWBwC2sABmqQBrNzWW0QBWBwlmDwBC+JEsUVBXFVXFxQ WyERBb/1k3rVlni5l3zZl375l4AZmOClM2mQCrLwDE0pmBGBD1KgBAVQAAIABrugmBqBJ2vwDbJg DhNJmX8ZEAA7 ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://www.ncbi.nlm.nih.gov/stat?jsdisabled=true&ncbi_app=pmc&ncbi_db=pmc&ncbi_pdid=article&ncbi_phid=84DA6863BB76E7E100000000011BEF32 R0lGODlhAgACAIAAAP///wAAACH5BAEAAAAALAAAAAACAAIAAAIChFEAOw== ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcstatic.css BODY.pmc-body { MARGIN: 1px } BODY.pmc-body-table { MARGIN: auto auto auto 1px } BODY.pmc-body-figure { MARGIN: auto auto auto 1px } .span-content { =09 } .search-reference-note-section { MARGIN: 8px 0px; WIDTH: 675px } .search-reference { FONT-SIZE: 80%; LINE-HEIGHT: 1.75em; FONT-FAMILY: arial, sans-serif; = BACKGROUND-COLOR: #e8e8c0 } .front-matter-section { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .section-content { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .section-title { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .toc-section-title { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .back-matter-section { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .footer-section { MARGIN-TOP: 0em; MARGIN-BOTTOM: 1.2em; WIDTH: 650px; WORD-WRAP: = break-word } .back-matter-section { FONT-SIZE: 80% } .section-content { MARGIN-TOP: 0px; LINE-HEIGHT: 1.31em } .section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .toc-section-title { PADDING-BOTTOM: 0.1em; PADDING-TOP: 0.1em } .banner-color1 { BACKGROUND-COLOR: #3c78bc } .banner-color2 { BACKGROUND-COLOR: #a0c0e0 } .banner-text { PADDING-RIGHT: 0.3em; FONT-WEIGHT: bold; FONT-SIZE: 135%; COLOR: = #ffffff; FONT-STYLE: italic; TEXT-ALIGN: right } .banner-text-sans { FONT-WEIGHT: bold; FONT-SIZE: 120%; COLOR: #ffffff; FONT-FAMILY: = sans-serif; TEXT-ALIGN: right } .banner-generic-logo-background { BACKGROUND-IMAGE: url(../pmcgifs/logo-generic.png); WIDTH: 500px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 75px; BACKGROUND-COLOR: silver } .banner-journal-publisher-over-image { MARGIN-LEFT: 84px; MARGIN-RIGHT: 10px } .banner-journal-name { FONT-WEIGHT: bold; FONT-SIZE: 20px; COLOR: white; PADDING-TOP: 5px; = FONT-FAMILY: Calibri, "Trebushet MS", Arial, sans-serif; HEIGHT: 48px; = TEXT-ALIGN: left } .banner-publisher-name { FONT-WEIGHT: bold; FONT-SIZE: 0.8em; COLOR: #a11; FONT-FAMILY: Calibri, = "Trebushet MS", Arial, sans-serif; TEXT-ALIGN: right } .banner-logo-with-journal-title-over { HEIGHT: 75px } .banner-logo-with-journal-title-over-placeholder { FONT-SIZE: 20px; Z-INDEX: 1000; LEFT: 105px; WIDTH: 390px; POSITION: = relative; TOP: -75px } .banner-logo-with-journal-title-over-placeholder-content { FONT-WEIGHT: bold; COLOR: black; PADDING-TOP: 5px; FONT-FAMILY: = Calibri, "Trebushet MS", Arial, sans-serif; HEIGHT: 48px; TEXT-ALIGN: = center } .over-logo-journal-title-sageopen { COLOR: #0055a5 } .over-logo-journal-title-sfesd { COLOR: #ffffff } .over-logo-journal-title-acssd { COLOR: #1e73b3 } .over-logo-journal-title-apasd { COLOR: #1e73b3 } .over-logo-journal-title-esesd { LINE-HEIGHT: 45px } .over-logo-journal-title-srfsd { LINE-HEIGHT: 45px } .over-logo-journal-title-tea { COLOR: #861316; TEXT-ALIGN: right } .over-logo-journal-title-rcpsychsd { COLOR: #44448a } .over-logo-journal-title-npgopen { COLOR: #ffffff } .menu-link { FONT-WEIGHT: bold; FONT-SIZE: 13px; COLOR: #0000c0; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-ALIGN: center; TEXT-DECORATION: none } A.menu-link:visited { FONT-WEIGHT: bold; FONT-SIZE: 13px; COLOR: #0000c0; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-ALIGN: center; TEXT-DECORATION: none } .menu-curr-page { FONT-WEIGHT: bold; FONT-SIZE: 13px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-ALIGN: center } A.menu-link:hover { COLOR: #ffffff; TEXT-DECORATION: none } .header-link { FONT-WEIGHT: bold; FONT-SIZE: 110%; COLOR: #0055aa; FONT-FAMILY: Arial, = sans-serif } .inpage-link { COLOR: #004080 } .sans75 { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .sans80 { FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .sans80b { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .sans90 { FONT-SIZE: 90%; FONT-FAMILY: Arial, sans-serif } .sans90b { FONT-WEIGHT: bold; FONT-SIZE: 90%; FONT-FAMILY: Arial, sans-serif } .sans { FONT-FAMILY: Arial, sans-serif } .sans105b { FONT-WEIGHT: bold; FONT-SIZE: 105%; FONT-FAMILY: Arial, sans-serif } .sans125b { FONT-WEIGHT: bold; FONT-SIZE: 125%; FONT-FAMILY: Arial, sans-serif } .msg-error { FONT-WEIGHT: bold; BACKGROUND: yellow; COLOR: red } .msg-warning { FONT-WEIGHT: bold; BACKGROUND: yellow; COLOR: brown } .eqn-image { MARGIN: 5px } A.navlink { COLOR: #0055aa; TEXT-DECORATION: none } A.navlink:hover { TEXT-DECORATION: underline } .navlink-box { FONT-WEIGHT: bold; FONT-SIZE: 80%; PADDING-BOTTOM: 2px; WIDTH: 683px; = PADDING-TOP: 2px; BORDER-BOTTOM: #cccccc 6px solid; FONT-FAMILY: tahoma, = verdana, Arial, sans-serif } .navlink-box-black { BORDER-BOTTOM: #000000 6px solid } .navlink-box-brtblue { BORDER-BOTTOM: #649afc 6px solid } .navlink-box-dkgreen { BORDER-BOTTOM: #006666 6px solid } .navlink-box-gray { BORDER-BOTTOM: #cccecc 6px solid } .navlink-box-green { BORDER-BOTTOM: #dce6e4 6px solid } .navlink-box-ltblue { BORDER-BOTTOM: #9ccefc 6px solid } .navlink-box-slateblue { BORDER-BOTTOM: #6c9acc 6px solid } .navlink-box-teal { BORDER-BOTTOM: #9ccecc 6px solid } .navlink-box-navy { BORDER-BOTTOM: #003399 6px solid } .navlink-box-bcwm-combo-blue { BORDER-BOTTOM: #639ace 3px solid } .fm-related-articles { BORDER-RIGHT: #ccd8e4 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #ccd8e4 1px solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN-LEFT: = 10px; BORDER-LEFT: #666699 1px solid; LINE-HEIGHT: 140%; MARGIN-RIGHT: = 15px; PADDING-TOP: 5px; BORDER-BOTTOM: #666699 1px solid } .nihms-highlight { FONT-WEIGHT: bold; FONT-SIZE: 0.8em; BACKGROUND: yellow; FLOAT: left; = MARGIN: 0px 0.2em 0px 0px; WIDTH: 4em; COLOR: #990000; TEXT-ALIGN: = center } .retraction-notice { FONT-WEIGHT: bold; FONT-SIZE: 1.2em; COLOR: red } .retraction-notice A { COLOR: red } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TR[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TD[content-type=3D'nowrap'] { WHITE-SPACE: nowrap } TABLE.rendered TD { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0.2em; = PADDING-TOP: 0.2em } TABLE.rendered TH { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0.2em; = PADDING-TOP: 0.2em } TABLE.rendered TD { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'top'] { VERTICAL-ALIGN: top } TABLE.rendered TD[valign=3D'middle'] { VERTICAL-ALIGN: middle } TABLE.rendered TD[valign=3D'bottom'] { VERTICAL-ALIGN: bottom } .head1 { FONT-SIZE: 120% } .head2 { FONT-SIZE: 110% } .head3 { FONT-SIZE: 105% } .head4 { FONT-SIZE: 99% } .head5 { FONT-SIZE: 90% } .acknowledgment-journal-title { FONT-STYLE: italic } DIV.exception-box { BORDER-RIGHT: silver 1px dashed; PADDING-RIGHT: 0.3em; BORDER-TOP: = silver 1px dashed; PADDING-LEFT: 0.3em; FONT-SIZE: 0.87em; = MARGIN-BOTTOM: 1.31em; PADDING-BOTTOM: 0.3em; BORDER-LEFT: silver 1px = dashed; PADDING-TOP: 0.3em; BORDER-BOTTOM: silver 1px dashed } DIV.exception-box .front-matter-section { FONT-SIZE: 1.14em } .exception-book-link-block .book-link { =09 } .exception-book-link-block .book-thumb { VERTICAL-ALIGN: middle; BORDER-TOP-STYLE: none; MARGIN-RIGHT: 0.5em; = BORDER-RIGHT-STYLE: none; BORDER-LEFT-STYLE: none; BORDER-BOTTOM-STYLE: = none } .exception-book-link-block .book-title { =09 } .box { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } DIV.p { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec-first { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.sec-first-last { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } .box { MARGIN-TOP: 1.31em; MARGIN-BOTTOM: 1.31em; WORD-WRAP: break-word } DIV.p-first { MARGIN-TOP: 0px } DIV.sec-first { MARGIN-TOP: 0px } DIV.p-last { MARGIN-BOTTOM: 0px } DIV.sec-last { MARGIN-BOTTOM: 0px } DIV.p-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } DIV.sec-first-last { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px } SUP { FONT-SIZE: 0.8em; LINE-HEIGHT: 0.8em } SUB { FONT-SIZE: 0.8em; LINE-HEIGHT: 0.8em } .footnote-char { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-ec { MARGIN: 0px 0.1em; WIDTH: 1em; HEIGHT: 1em } .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-irp { WIDTH: 1.5em; HEIGHT: 1.1em } .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.1em } .tocentry .footnote-char-ec { WIDTH: 1.5em; HEIGHT: 1.3em } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcbase1.css BODY { BACKGROUND-COLOR: #f8f8f8 } .small-caps { FONT-SIZE: 80%; FONT-VARIANT: small-caps } .monospace { FONT-FAMILY: monospace } .pmctop-bg { BACKGROUND-COLOR: #fffeee } A.pmctop { FONT-SIZE: 12px; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .pmc-body A:active { TEXT-DECORATION: underline } .pmc-body A:hover { TEXT-DECORATION: underline } .pmc-body-table A:active { TEXT-DECORATION: underline } .pmc-body-table A:hover { TEXT-DECORATION: underline } .pmc-body-figure A:active { TEXT-DECORATION: underline } .pmc-body-figure A:hover { TEXT-DECORATION: underline } .pmc-body A:hover { TEXT-DECORATION: underline } .pmc-body A:hover { =09 } .pmc-body-table A:hover { =09 } .pmc-body-figure A:hover { =09 } HR { COLOR: #0072a8 } .base-highlight1 { BACKGROUND-COLOR: #ebebeb } .base-highlight2 { BACKGROUND-COLOR: #cccccc } .controls { FONT-WEIGHT: bold; FONT-SIZE: 75%; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-DECORATION: none } .formtext { FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .link { COLOR: #0055aa; TEXT-DECORATION: none } .footer-link { FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: center } .side-head { FONT-WEIGHT: bold; FONT-SIZE: 90%; FONT-FAMILY: Arial, sans-serif } .side-subhead { MARGIN-TOP: 10px; FONT-WEIGHT: bold; FONT-SIZE: 75%; FONT-FAMILY: = Arial, sans-serif } .side-item { FONT-SIZE: 75%; PADDING-BOTTOM: 2px; MARGIN: 2px 1px 2px 4px; = BORDER-BOTTOM: #c0c0c0 1px solid; FONT-FAMILY: Arial, sans-serif } .side-curr-item { FONT-SIZE: 75%; PADDING-BOTTOM: 2px; MARGIN: 2px 1px 2px 4px; = BORDER-BOTTOM: #c0c0c0 1px solid; FONT-FAMILY: Arial, sans-serif } .side-item A { COLOR: #0055aa; TEXT-DECORATION: none } .side-curr-item { COLOR: #808080 } .toc-header-vid { MARGIN-TOP: 1.1em; FONT-WEIGHT: bold; FONT-SIZE: 120%; MARGIN-BOTTOM: = 1.1em; LINE-HEIGHT: 1.1em; FONT-FAMILY: Arial, sans-serif } .more-iss-text { MARGIN-TOP: 1.35em; FONT-WEIGHT: bold; MARGIN-BOTTOM: 1.35em; = FONT-FAMILY: Arial, sans-serif } .more-iss-link { COLOR: #0055aa; TEXT-DECORATION: none } .arc-issue { FONT-SIZE: 80%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-ALIGN: center; TEXT-DECORATION: none } .toc-entry { LINE-HEIGHT: 1.12em } .portal-tocentry { LINE-HEIGHT: 1.12em } .toc-comment { FONT-SIZE: 70%; FONT-FAMILY: Arial, sans-serif } .toc-title { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .toc-author { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-cit-ver { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif } .toc-cit-jour { FONT-SIZE: 75%; COLOR: #666666; FONT-STYLE: italic; FONT-FAMILY: Arial, = sans-serif } .toc-cit-vol { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif } .toc-cit-page { FONT-WEIGHT: bold; FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, = sans-serif } .toc-cit-date { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif; = WHITE-SPACE: nowrap } .toc-pmcid { FONT-SIZE: 75%; COLOR: #666666; FONT-FAMILY: Arial, sans-serif; = WHITE-SPACE: nowrap } .toc-link { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-DECORATION: none } A.toc-link { COLOR: #004080 } .toc-divider { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-DECORATION: none } .toc-corrected-citation { MARGIN-LEFT: 1em } .toc-corrected-prefix { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-1st-author-etal { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-citation-title { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-prefix { FONT-WEIGHT: 600 } .toc-corrected-citation-info { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .toc-corrected-citation-info .citation-abbreviation { FONT-STYLE: italic } .toc-entry-abstract-toc { PADDING-RIGHT: 2em; PADDING-LEFT: 2em; FONT-SIZE: 75%; PADDING-BOTTOM: = 0px; COLOR: #333; PADDING-TOP: 0px; FONT-FAMILY: Arial, san-serif } .cited-article-fm { BORDER-RIGHT: 1px solid; PADDING-RIGHT: 8px; BORDER-TOP: 1px solid; = PADDING-LEFT: 8px; MARGIN-LEFT: 0px; BORDER-LEFT: 1px solid; = BORDER-BOTTOM: 1px solid; BACKGROUND-COLOR: #ebebeb } .citing-article-fm { PADDING-RIGHT: 8px; PADDING-LEFT: 8px; MARGIN-LEFT: 0px } .sidefm-pmchead { FONT-WEIGHT: bold; FONT-SIZE: 85%; COLOR: #0055aa; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-DECORATION: none } .sidefm-pmhead { FONT-WEIGHT: bold; FONT-SIZE: 85%; COLOR: #0055aa; FONT-FAMILY: = Verdana, Arial, sans-serif; TEXT-DECORATION: none } .sidefm-pmsubhead { MARGIN-TOP: 10px; FONT-WEIGHT: bold; FONT-SIZE: 75%; COLOR: #000000; = FONT-FAMILY: Arial, sans-serif } .sidefm-pmclink { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .sidefm-pmart { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .side-section { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .side-caption { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .figure-table-caption-in-article { FONT-SIZE: 75%; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } SELECT.sidefm-pmart { WIDTH: 145px } .figure-table-caption-in-article { COLOR: #000000; LINE-HEIGHT: 1.5em } .sidefm-pmclink-item { PADDING-LEFT: 10px } .sidefm-pmclink-item A { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmccurrent-item A { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmclink-item A:hover { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmccurrent-item A:hover { DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: 2px; LINE-HEIGHT: = 1.5em; BORDER-BOTTOM: #c0c0c0 1px dotted; TEXT-DECORATION: none } .sidefm-pmclink-item A { COLOR: #004080 } .sidefm-pmclink-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #b8c8d8 } .sidefm-pmccurrent-item A { CURSOR: default; COLOR: #808080 } .sidefm-pmccurrent-item A:hover { CURSOR: default; COLOR: #808080 } .sidefm-pmccurrent-item A:hover { BACKGROUND-COLOR: #dcdcdc } .side-section-curr { FONT-SIZE: 75%; COLOR: #808080; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .sidebar-cell .sidefm-supplink { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .sidebar-cell .side-supplink { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } A.sidefm-supplink { COLOR: #b55a00; TEXT-DECORATION: none } A.side-supplink { COLOR: #b55a00; TEXT-DECORATION: none } .side-section-group { PADDING-RIGHT: 3px; BORDER-TOP: #0077aa 1px solid; PADDING-LEFT: 3px; = LINE-HEIGHT: 100%; TEXT-DECORATION: none } .head-separate { MARGIN-BOTTOM: 1.2em } .links-box { BORDER-RIGHT: #ccd8e4 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #ccd8e4 1px solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: 1em = 0px; BORDER-LEFT: #666699 1px solid; PADDING-TOP: 5px; BORDER-BOTTOM: = #666699 1px solid } :unknown { BORDER-RIGHT: #336699 1px dotted; BORDER-TOP: #336699 1px dotted; = BORDER-LEFT: #336699 1px dotted; BORDER-BOTTOM: #336699 1px dotted } .main-table-content { MARGIN-LEFT: 9px } .main-figure-content { MARGIN-LEFT: 9px } DIV.fm-author { MARGIN-TOP: 16px! important; MARGIN-BOTTOM: 16px! important } .fm-affl { FONT-WEIGHT: normal; COLOR: #5e5e5e! important } .fm-footnote { FONT-WEIGHT: normal; COLOR: #5e5e5e! important } .fm-editor { FONT-WEIGHT: normal; COLOR: #5e5e5e! important } DIV.fm-affl { MARGIN: 0px } DIV.fm-footnote { MARGIN: 0px } .fm-footnote .fm-affl { FONT-SIZE: 1em } .fm-footnote .fm-footnote { FONT-SIZE: 1em } .fm-affl .fm-affl { FONT-SIZE: 1em } DIV.fm-copyright { MARGIN-TOP: 12px! important; MARGIN-BOTTOM: 12px! important } DIV.fm-pubdate { MARGIN-TOP: 12px! important; MARGIN-BOTTOM: 12px! important } DIV.fm-citation { MARGIN-TOP: 0px! important } .fm-citation-ids { PADDING-LEFT: 1em; FONT-SIZE: 85%; FONT-FAMILY: Arial,sans-serif; = WHITE-SPACE: nowrap; TEXT-ALIGN: right } .fm-citation-ids-label { COLOR: #666 } .fm-citation-pmcid { =09 } .fm-citation-manuscriptid { =09 } .fm-citation-other-versions-label { CURSOR: hand; COLOR: #0050a0 } .fm-citation-this-version-label { COLOR: #666666 } .fm-citation-versions { POSITION: relative } .fm-citation-versions .fm-citation-verions-list-canvas { BORDER-RIGHT: #444 1em solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #444 = 1em solid; DISPLAY: none; PADDING-LEFT: 0.5em; RIGHT: 0px; = PADDING-BOTTOM: 0.5em; BORDER-LEFT: #444 1em solid; PADDING-TOP: 0.5em; = BORDER-BOTTOM: #444 1em solid; POSITION: absolute; TOP: 1.1em; = BACKGROUND-COLOR: #444 } .fm-citation-versions:hover .fm-citation-verions-list-canvas { DISPLAY: block } .show-hover .fm-citation-verions-list-canvas { DISPLAY: block } .fm-citation-versions .fm-citation-verions-list { BORDER-RIGHT: #639ace 3px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: = #639ace 3px solid; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = BORDER-LEFT: #639ace 3px solid; PADDING-TOP: 0.5em; BORDER-BOTTOM: = #639ace 3px solid; BACKGROUND-COLOR: #f8f8f8; TEXT-ALIGN: left } .fm-citation-verions-list .version { MARGIN-LEFT: 15px } .fm-copyright { MARGIN-TOP: 6px } .links-box .fm-footnote { MARGIN: 0px } .tocentry { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-TOP: 1.12em; MARGIN-BOTTOM: 1.12em } .toc-entry-alt-lang { MARGIN-LEFT: 2.5em } .toc-entry-alt-lang-msg { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .portal-tocentry { MARGIN-TOP: 1.6ex; MARGIN-BOTTOM: 2ex; MARGIN-RIGHT: 1em } .button-elsevierwt { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .elsevierwt-sponsored-label { FONT-WEIGHT: 600; COLOR: #f8f8f8 } .banner-journal-publisher-over-image-elsevierwt { MARGIN-LEFT: 20px; OVERFLOW: hidden; COLOR: #9a7947; LINE-HEIGHT: = 1.5em; MARGIN-RIGHT: 145px; FONT-FAMILY: Georgia, "Times New Roman", = Times, serif; POSITION: relative; TOP: -30px; HEIGHT: 75px } .banner-journal-name-elsevierwt { FONT-WEIGHT: 600; FONT-SIZE: 1.2em; MARGIN-LEFT: 1em; COLOR: #954a4a } A.elsevierwt-button-link { LEFT: 360px; POSITION: relative; TOP: 40px } A.elsevierwt-button-link:hover { BACKGROUND-COLOR: #f1e8ce } .fm-elsevierwt-disclaimer { MARGIN-TOP: 12px; FONT-SIZE: 0.68em; MARGIN-BOTTOM: 12px; FONT-FAMILY: = Arial, sans-serif } UL.back-ref-list-1st-line-shifted { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .ref-cit-blk { MARGIN-TOP: 1.4em; LINE-HEIGHT: 1.4em } .back-ref-list-1st-line-shifted LI { MARGIN-TOP: 1.4em; LINE-HEIGHT: 1.4em } .back-ref-list LI { MARGIN-TOP: 1.4em; LINE-HEIGHT: 1.4em } DIV.ref-label { BORDER-RIGHT: #f8f8f8 1px solid; BORDER-TOP: #f8f8f8 1px solid; FLOAT: = left; BORDER-LEFT: #f8f8f8 1px solid; WIDTH: 45px; BORDER-BOTTOM: = #f8f8f8 1px solid; TEXT-ALIGN: right } DIV.ref-cit { MARGIN-LEFT: 55px } SPAN.ref-label { FONT-STYLE: italic } SPAN.ref-cit { =09 } .back-ref-list-1st-line-shifted LI { MARGIN-LEFT: 2em; TEXT-INDENT: -1.5em; LIST-STYLE-TYPE: none } .array-table { MARGIN-TOP: 1em; MARGIN-BOTTOM: 1em; WIDTH: 100%; LINE-HEIGHT: 1.31em; = BACKGROUND-COLOR: #f4f4f4 } .array-table-inline { MARGIN-TOP: 1em; MARGIN-BOTTOM: 1em; WIDTH: 100%; LINE-HEIGHT: 1.31em; = BACKGROUND-COLOR: #f4f4f4 } .array-table TD { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0em; = PADDING-TOP: 0em } .array-table-inline { DISPLAY: inline } .list-item-w-pw { BORDER-RIGHT: #f8f8f8 1px solid; BORDER-TOP: #f8f8f8 1px solid; = BORDER-LEFT: #f8f8f8 1px solid; BORDER-BOTTOM: #f8f8f8 1px solid } .list-item-w-pw-prefix-word { DISPLAY: inline-block; POSITION: relative; TEXT-ALIGN: right } .list-item-w-pw-content { POSITION: relative; TOP: -1.35em } .list-item-p-question { FONT-WEIGHT: bold } SPAN.underline { BORDER-BOTTOM: black 1px solid } SPAN.double-underline { BORDER-BOTTOM: black 3px double } SPAN.bold-double-underline { BORDER-BOTTOM: black 3px double } .verse-group { FONT-SIZE: 1.12em; MARGIN: 1.31em 2em; LINE-HEIGHT: 1.16em; = FONT-FAMILY: "Monotype Corsiva", "Apple Chancery", "URW Chancery L", = cursive } .internal-control { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0.5em; MARGIN: 1.5em auto; WIDTH: 95%; PADDING-TOP: = 0.5em; BACKGROUND-COLOR: #f0f0f0 } .sidebar-menu-square-image-holder { PADDING-RIGHT: 0.35em; VERTICAL-ALIGN: middle; _padding-top: 0.35em } .figure-role { DISPLAY: block; MARGIN: 1em 0px } DIV.signature { MARGIN: 1.8em 0px; FONT-FAMILY: "Monotype Corsiva", "Apple Chancery", = "URW Chancery L", cursive } DIV.simple-list-item-w-label { FLOAT: left; TEXT-INDENT: -2em } .selective-deposit-msg { BORDER-RIGHT: #f4f4f4 0.5em solid; BORDER-TOP: #f4f4f4 0.5em solid; = FONT-SIZE: 80%; BORDER-LEFT: #f4f4f4 0.5em solid; BORDER-BOTTOM: #f4f4f4 = 0.5em solid; FONT-FAMILY: Arial,sans-serif; BACKGROUND-COLOR: #f4f4f4 } .fm-title { MARGIN-TOP: 16px } .fm-trans-title { MARGIN-TOP: 16px } .ukpmc-tocentry-icon { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: text-bottom; MARGIN-RIGHT: 0.25em; = BORDER-RIGHT-WIDTH: 0px } .holding-tocentry-icon { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; VERTICAL-ALIGN: text-bottom; MARGIN-RIGHT: 0.25em; = BORDER-RIGHT-WIDTH: 0px } .i18n-debug { BACKGROUND-COLOR: #fff0df } .i18n-debug * { BACKGROUND-COLOR: #fff0df } .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffe2bf } .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffe2bf } .i18n-debug .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffd39f } .i18n-debug .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffd39f } .i18n-debug .i18n-debug .i18n-debug .i18n-debug { BACKGROUND-COLOR: #ffc47f } .i18n-debug .i18n-debug .i18n-debug .i18n-debug * { BACKGROUND-COLOR: #ffc47f } A.i18n-switcher { FONT-WEIGHT: normal; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } A.i18n-switcher:hover { FONT-WEIGHT: normal; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } A.i18n-switcher-current { FONT-WEIGHT: bold; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } A.i18n-switcher-current:hover { FONT-WEIGHT: bold; FONT-SIZE: 0.75em; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } IMG.i18n-switcher { VERTICAL-ALIGN: super; WIDTH: 11px; BORDER-TOP-STYLE: none; = MARGIN-RIGHT: 2px; BORDER-RIGHT-STYLE: none; BORDER-LEFT-STYLE: none; = HEIGHT: 8px; BORDER-BOTTOM-STYLE: none } TD.content-cell { PADDING-LEFT: 0.5em } TD.thumb-cell { WIDTH: 110px } TD.caption-cell { TEXT-ALIGN: left } A.icon-reflink { DISPLAY: block } DIV.thumb-ph { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = PADDING-TOP: 0.5em } DIV.caption-ph { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = PADDING-TOP: 0.5em } DIV.thumb-ph { PADDING-RIGHT: 0px } .figpopup { CURSOR: hand; WHITE-SPACE: nowrap; POSITION: relative } .figpopup > DIV { CURSOR: hand; WHITE-SPACE: nowrap; POSITION: relative } A.fig-table-link:hover { Z-INDEX: 10; COLOR: #444 } .figpopup:hover { Z-INDEX: 10; COLOR: #444 } .figpopup:hover .large-thumb-canvas { Z-INDEX: 10; COLOR: #444 } .large-thumb-canvas { BORDER-RIGHT: #444 1em solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #444 = 1em solid; DISPLAY: none; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = MARGIN: 0.5em; BORDER-LEFT: #444 1em solid; COLOR: #444; PADDING-TOP: = 0.5em; BORDER-BOTTOM: #444 1em solid; POSITION: absolute; = BACKGROUND-COLOR: #444 } .large-thumb-canvas-1 { BORDER-RIGHT: #eee 0.25em solid; BORDER-TOP: #eee 0.25em solid; = DISPLAY: block; BORDER-LEFT: #eee 0.25em solid; BORDER-BOTTOM: #eee = 0.25em solid } IMG.large-thumb { WIDTH: 450px } DIV.small-thumb-canvas { BORDER-RIGHT: #444 1px solid; BORDER-TOP: #444 1px solid; MAX-WIDTH: = 104px; BORDER-LEFT: #444 1px solid; WIDTH: 104px; BORDER-BOTTOM: #444 = 1px solid; WHITE-SPACE: normal; WORD-WRAP: break-word } DIV.small-thumb-canvas-1 { BORDER-RIGHT: white 1px solid; BORDER-TOP: white 1px solid; = BORDER-LEFT: white 1px solid; BORDER-BOTTOM: white 1px solid } IMG.small-thumb { BORDER-RIGHT: #444 1px solid; BORDER-TOP: #444 1px solid; BORDER-LEFT: = #444 1px solid; WIDTH: 100px; BORDER-BOTTOM: #444 1px solid } .canvas-figure-ref-outer { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; MARGIN: = 1.31em 0.5em; BORDER-LEFT: #aaaaaa 1px solid; BORDER-BOTTOM: #aaaaaa 1px = solid } .canvas-table-ref-outer { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; MARGIN: = 1.31em 0.5em; BORDER-LEFT: #aaaaaa 1px solid; BORDER-BOTTOM: #aaaaaa 1px = solid } .canvas-media-ref-outer { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; MARGIN: = 1.31em 0.5em; BORDER-LEFT: #aaaaaa 1px solid; BORDER-BOTTOM: #aaaaaa 1px = solid } .canvas-figure-ref-inner { BORDER-RIGHT: #f0f0f0 3px solid; BORDER-TOP: #f0f0f0 3px solid; = BORDER-LEFT: #f0f0f0 3px solid; BORDER-BOTTOM: #f0f0f0 3px solid } .canvas-table-ref-inner { BORDER-RIGHT: #f0f0f0 3px solid; BORDER-TOP: #f0f0f0 3px solid; = BORDER-LEFT: #f0f0f0 3px solid; BORDER-BOTTOM: #f0f0f0 3px solid } .canvas-media-ref-inner { BORDER-RIGHT: #f0f0f0 3px solid; BORDER-TOP: #f0f0f0 3px solid; = BORDER-LEFT: #f0f0f0 3px solid; BORDER-BOTTOM: #f0f0f0 3px solid } DIV.fig-label { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .figpopup-sensitive-area { FILTER: alpha(opacity=3D0); CURSOR: hand; COLOR: transparent; POSITION: = absolute; TOP: 0px; BACKGROUND-COLOR: transparent; TEXT-DECORATION: = none; opacity: 0 } .canvas-media-player-outer { BORDER-RIGHT: #4a4a4a 2px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #4a4a4a 2px solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; MARGIN: auto; = BORDER-LEFT: #4a4a4a 2px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #4a4a4a = 2px solid } .canvas-media-player-inner { BORDER-RIGHT: #4a4a4a 2px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #4a4a4a 2px solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; BORDER-LEFT: = #4a4a4a 2px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #4a4a4a 2px solid; = BACKGROUND-COLOR: #4a4a4a; TEXT-ALIGN: center } .canvas-player-screen { DISPLAY: block; MARGIN: auto; CURSOR: hand; POSITION: relative; = BACKGROUND-COLOR: #4a4a4a; TEXT-ALIGN: center; TEXT-DECORATION: none } .splash-ph { MAX-WIDTH: 100%; MARGIN: auto; HEIGHT: 100% } .player-play-btn { VERTICAL-ALIGN: middle; POSITION: relative } IMG.player-splash { LEFT: 0px; WIDTH: 100%; POSITION: absolute; TOP: 0px; HEIGHT: 100% } .supplementary-material-media-label-caption { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; = PADDING-TOP: 0.5em; BACKGROUND-COLOR: #f4f4f4 } DIV.tileshop-panel-canvas { BORDER-RIGHT: gray 1px solid; BORDER-TOP: gray 1px solid; DISPLAY: = block; MAX-WIDTH: 100%; MARGIN: auto; BORDER-LEFT: gray 1px solid; ; = WIDTH: expression( (this._w =3D this.clientWidth), (this._max_width && = this._w > this._max_width ? this.style.width =3D this._max_width + 'px' = : 0), "auto"); BORDER-BOTTOM: gray 1px solid; ZOOM: 1 } .tileshop-panel-canvas A { DISPLAY: block; ZOOM: 1 } .tileshop-panel-bar { MAX-WIDTH: 100%; MARGIN: auto; LINE-HEIGHT: 2em; BACKGROUND-COLOR: = #ecf0f4; TEXT-ALIGN: center } IMG.tileshop-image { MAX-WIDTH: 100%; ; WIDTH: expression( (this._w =3D this.clientWidth), = (this.style.width =3D 1 + 'px'), (this._w > this.parentNode.clientWidth = ? this.style.width =3D this.parentNode.clientWidth + 'px' : = this.style.width =3D this._w + 'px'), "auto" ); CURSOR: = url(http://www.ncbi.nlm.nih.gov/corehtml/jsutils/cur/zoomin.cur), = pointer; BORDER-TOP-STYLE: none; ZOOM: 1; BORDER-RIGHT-STYLE: none; = BORDER-LEFT-STYLE: none; BORDER-BOTTOM-STYLE: none } UL.ui-ncbiautocomplete-options { BORDER-RIGHT: #336699 1px solid; BORDER-TOP: #336699 1px solid; = FONT-SIZE: 12px; MIN-HEIGHT: 1em; BORDER-LEFT: #336699 1px solid; = MAX-HEIGHT: 218px; BORDER-BOTTOM: #336699 1px solid; HEIGHT: auto; = BACKGROUND-COLOR: #f6f8fc } UL.ui-ncbiautocomplete-options LI SPAN { FONT-WEIGHT: bolder; COLOR: #ff6d30 } DIV.ui-ncbiautocomplete-holder { MIN-HEIGHT: 1em; MAX-HEIGHT: 218px; HEIGHT: auto } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcbars-slateblue.css .doc-group1 { FONT-WEIGHT: bold; FONT-SIZE: 110%; COLOR: white; FONT-FAMILY: Verdana, = sans-serif; BACKGROUND-COLOR: #0072a8 } .doc-group2 { FONT-WEIGHT: bold; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = BACKGROUND-COLOR: #cccccc; TEXT-ALIGN: center } .doc-group3 { FONT-WEIGHT: bold; COLOR: #000000; FONT-FAMILY: Arial, sans-serif; = BACKGROUND-COLOR: #cccccc; TEXT-ALIGN: center } .doc-group4 { =09 } .toc-supp-link { FONT-SIZE: 75%; COLOR: #e64a00; FONT-FAMILY: Arial, sans-serif; = TEXT-DECORATION: none } .toc-highlight1 { BACKGROUND-COLOR: #ffffd0 } .toc-highlight2 { BACKGROUND-COLOR: #ace4ff } .head1 { BORDER-RIGHT: #0072a8 1pt solid; BORDER-TOP: #0072a8 1pt solid; = FONT-WEIGHT: bold; FONT-SIZE: 110%; BORDER-LEFT: #0072a8 1pt solid; = COLOR: white; BORDER-BOTTOM: #0072a8 1pt solid; FONT-FAMILY: Verdana, = sans-serif; BACKGROUND-COLOR: #0072a8; TEXT-ALIGN: center } .head1A { FONT-WEIGHT: bold; COLOR: #004080; FONT-FAMILY: Arial, sans-serif; = BACKGROUND-COLOR: #cccccc } .append-head1 { FONT-WEIGHT: bold; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: center } .colorbar-link { COLOR: #ffffff } .head1 A:link { COLOR: white } .head1 A:visited { COLOR: white } .head1A A:link { COLOR: white } .head1A A:visited { COLOR: white } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcbody4.css .fm-vol-iss-date { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: left } .fm-citation { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; TEXT-ALIGN: left } .fm-citation-ids { FONT-SIZE: 75% } .fm-citation .fm-vol-iss-date { FONT-SIZE: 100% } .pubnote { FONT-WEIGHT: bold; FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .pubnote-hilite { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif; BACKGROUND-COLOR: = #ebebeb } .fm-dochead { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .fm-doctopic { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-docsubject { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-ser-title { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .fm-supp-title { FONT-WEIGHT: bold; FONT-SIZE: 80%; FONT-FAMILY: Arial, sans-serif } .fm-title { FONT-WEIGHT: bold; FONT-SIZE: 125%; FONT-FAMILY: Arial, sans-serif } .fm-subtitle { FONT-WEIGHT: bold; FONT-FAMILY: Arial, sans-serif } .fm-trans-title { FONT-SIZE: 120%; FONT-FAMILY: Arial, sans-serif } .fm-trans-subtitle { FONT-SIZE: 105%; FONT-FAMILY: Arial, sans-serif } .fm-author { FONT-SIZE: 110%; FONT-FAMILY: Arial, sans-serif } .fm-affl { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-pubdate { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-footnote { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-editor { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .fm-author .fm-footnote { FONT-SIZE: 68.5% } .fm-author .fm-affl { FONT-SIZE: 68.5% } .fm-author .fm-footnote .fm-affl { FONT-SIZE: 100%; FONT-FAMILY: Arial, sans-serif } .fm-editor .fm-footnote .fm-affl { FONT-SIZE: 100%; FONT-FAMILY: Arial, sans-serif } .fm-editor .fm-footnote { FONT-SIZE: 100%; FONT-FAMILY: Arial, sans-serif } .fm-role { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif } .fm-copyright { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .pmcnote { FONT-SIZE: 85%; FONT-FAMILY: Arial, sans-serif } .abs-head2 { FONT-FAMILY: Arial, sans-serif } .abs-head2 { FONT-WEIGHT: bold } .kwd-label { FONT-WEIGHT: bold } .abs-head3 { FONT-FAMILY: Arial, sans-serif } .head2 { FONT-WEIGHT: bold; FONT-FAMILY: Arial, sans-serif } .head3 { FONT-STYLE: italic; FONT-FAMILY: Arial, sans-serif } .head4 { FONT-FAMILY: Arial, sans-serif } .head5 { =09 } .kwd-text { FONT-SIZE: 85% } .eqn-image { TEXT-ALIGN: center } .eqn-id { FONT-WEIGHT: bold; TEXT-ALIGN: right } .box { BORDER-RIGHT: #607080 1px solid; BORDER-TOP: #607080 1px solid; = OVERFLOW: auto; BORDER-LEFT: #607080 1px solid; BORDER-BOTTOM: #607080 = 1px solid; BACKGROUND-COLOR: #e4e8ec } .boxhead1 { FONT-WEIGHT: bold; FONT-SIZE: 105%; FONT-FAMILY: Arial, sans-serif } .boxhead2 { FONT-WEIGHT: bold } A.cite-reflink { COLOR: #0050a0 } .fig-table-link { COLOR: #0050a0 } A.int-reflink { COLOR: #0050a0 } A.ext-reflink { COLOR: #0050a0 } .figwind-cite { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .figwind-copyrt { FONT-SIZE: 75%; FONT-FAMILY: Arial, sans-serif } .product-source { FONT-STYLE: italic } .signature-group { FONT-WEIGHT: bold; MARGIN-LEFT: 2em; FONT-STYLE: italic } TR[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TD[content-type=3D'shaded-medium'] { BACKGROUND-COLOR: #cccccc } TR[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TD[content-type=3D'shaded-light'] { BACKGROUND-COLOR: #e2e2e2 } TR[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } TD[content-type=3D'shaded-dark'] { BACKGROUND-COLOR: #aaaaaa } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: 7bit Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/pmcrefs3.css .ref-id { } .ref-title { FONT-WEIGHT: bold } .ref-author { } .ref-journal { FONT-STYLE: italic } .ref-pubdate { } .ref-vol { FONT-WEIGHT: bold } .ref-iss { } .ref-page { } .ref-edition { FONT-STYLE: italic } .ref-editor { FONT-STYLE: italic } .ref-pubname { FONT-STYLE: italic } .ref-publoc { FONT-STYLE: italic } .ref-extlink { COLOR: #0050a0 } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/css/noext-menu.css DIV.sec DIV.other-sections { PADDING-RIGHT: 0.25em; PADDING-LEFT: 0.25em; FLOAT: right; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; POSITION: relative } DIV.other-sections UL { LINE-HEIGHT: 1.2em } .noext-menu UL { DISPLAY: none } .noext-menu { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } .noext-menu UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } .noext-menu A { DISPLAY: block; CURSOR: pointer; TEXT-DECORATION: underline; _display: = inline; outline: none } .noext-menu LI { =09 } .noext-menu A.first-link { FONT-SIZE: 0.65em; TEXT-TRANSFORM: none; WHITE-SPACE: nowrap; = TEXT-DECORATION: none } .noext-menu A.first-link:hover { TEXT-DECORATION: none! important } UL.noext-menu LI SPAN.delta { =09 } .noext-menu LI UL.submenu { DISPLAY: none; FONT-SIZE: 0.75em; POSITION: absolute } .noext-menu LI UL UL { MARGIN: -1em 0px 0px 10em } UL.noext-menu LI.submenu-item UL { DISPLAY: none; POSITION: absolute } UL.noext-menu LI.active-item UL { LEFT: 3px } UL.noext-menu LI UL.opened { BORDER-RIGHT: transparent 1px solid; PADDING-RIGHT: 0.25em; BORDER-TOP: = transparent 1px solid; MARGIN-TOP: 0.25em; MIN-WIDTH: 200px; DISPLAY: = block; PADDING-LEFT: 0.25em; Z-INDEX: 5; RIGHT: -0.1em; MAX-WIDTH: = 300px; PADDING-BOTTOM: 0.25em; BORDER-LEFT: transparent 1px solid; ; = WIDTH: expression(this.clientWidth > 300 ? "300px" : "200px"); = PADDING-TOP: 0.25em; BORDER-BOTTOM: transparent 1px solid; TOP: 1.4em; = _top: 1.6em } UL.noext-menu LI UL.opened LI { MARGIN-BOTTOM: 3px } UL.noext-menu LI UL.opened LI.active-item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BACKGROUND-COLOR: #aaaaaa } UL.opened LI.active-item A { COLOR: #ffffff } UL.noext-menu LI UL A { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: 0px = 3px; COLOR: #222222; PADDING-TOP: 2px; TEXT-DECORATION: none } .noext-menu-hidden { COLOR: transparent! important; BACKGROUND-COLOR: transparent! important } .noext-menu-hidden A.first-link { COLOR: transparent! important; BACKGROUND-COLOR: transparent! important } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/core/extjs/ext-2.2/resources/css/panel.css .x-panel { BORDER-RIGHT: #99bbe8 0px solid; BORDER-TOP: #99bbe8 0px solid; = BORDER-LEFT: #99bbe8 0px solid; BORDER-BOTTOM: #99bbe8 0px solid } .x-panel-header { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #99bbe8 1px solid; PADDING-LEFT: 5px; BACKGROUND: = url(../images/default/panel/white-top-bottom.gif) repeat-x 0px -1px; = PADDING-BOTTOM: 4px; FONT: bold 11px/15px = tahoma,arial,verdana,sans-serif; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: #99bbe8 1px = solid; ZOOM: 1 } .x-panel-body { BORDER-RIGHT: #99bbe8 1px solid; BORDER-TOP: #99bbe8 0px; BACKGROUND: = white; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 1px solid; BORDER-BOTTOM: = #99bbe8 1px solid; POSITION: relative } .x-panel-bbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar-noheader .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-body-noheader { BORDER-TOP: #99bbe8 1px solid } .x-panel-mc .x-panel-body { BORDER-TOP: #99bbe8 1px solid } .x-panel-header { OVERFLOW: hidden; ZOOM: 1 } .x-panel-tl .x-panel-header { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: none transparent scroll repeat 0% 0%; PADDING-BOTTOM: = 4px; FONT: bold 11px tahoma,arial,verdana,sans-serif; BORDER-LEFT: 0px; = COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: 0px } .x-panel-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-window-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-panel-inline-icon { BACKGROUND-POSITION: 0px 0px; MARGIN-TOP: -1px; MARGIN-BOTTOM: -1px; = VERTICAL-ALIGN: middle; WIDTH: 16px; MARGIN-RIGHT: 4px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px } .x-panel-tc { BACKGROUND: url(../images/default/panel/top-bottom.gif) repeat-x 0px = 0px; OVERFLOW: hidden } .ext-strict .ext-ie7 .x-panel-tc { OVERFLOW: visible } .x-panel-tl { PADDING-LEFT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat 0px 0px; = BORDER-BOTTOM: #99bbe8 1px solid; ZOOM: 1 } .x-panel-tr { PADDING-RIGHT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat right 0px; = ZOOM: 1 } .x-panel-bc { BACKGROUND: url(../images/default/panel/top-bottom.gif) repeat-x 0px = bottom; ZOOM: 1 } .x-panel-bc .x-panel-footer { ZOOM: 1 } .x-panel-bl { PADDING-LEFT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat 0px bottom; = ZOOM: 1 } .x-panel-br { PADDING-RIGHT: 6px; BACKGROUND: = url(../images/default/panel/corners-sprite.gif) no-repeat right bottom; = ZOOM: 1 } .x-panel-mc { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: #dfe8f6; PADDING-BOTTOM: 0px; MARGIN: 0px; FONT: 11px = tahoma,arial,helvetica,sans-serif; BORDER-LEFT: 0px; PADDING-TOP: 6px; = BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { PADDING-LEFT: 6px; BACKGROUND: = url(../images/default/panel/left-right.gif) #fff repeat-y 0px 0px; ZOOM: = 1 } .x-panel-mr { PADDING-RIGHT: 6px; BACKGROUND: = url(../images/default/panel/left-right.gif) repeat-y right 0px; ZOOM: 1 } .x-panel-bc .x-panel-footer { PADDING-BOTTOM: 6px } .x-panel-nofooter .x-panel-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-nofooter .x-window-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-bwrap { LEFT: 0px; OVERFLOW: hidden; ZOOM: 1; TOP: 0px } .x-panel-body { OVERFLOW: hidden; ZOOM: 1 } .x-panel-collapsed .x-resizable-handle { DISPLAY: none } .ext-gecko .x-panel-animated DIV { OVERFLOW: hidden! important } .x-plain-body { OVERFLOW: hidden } .x-plain-bbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-tbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-bwrap { OVERFLOW: hidden; ZOOM: 1 } .x-plain { OVERFLOW: hidden } .x-tool { BACKGROUND: url(../images/default/panel/tool-sprites.gif) no-repeat; = FLOAT: right; MARGIN-LEFT: 2px; OVERFLOW: hidden; WIDTH: 15px; CURSOR: = pointer; HEIGHT: 15px } .x-tool-toggle { BACKGROUND-POSITION: 0px -60px } .x-tool-toggle-over { BACKGROUND-POSITION: -15px -60px } .x-panel-collapsed .x-tool-toggle { BACKGROUND-POSITION: 0px -75px } .x-panel-collapsed .x-tool-toggle-over { BACKGROUND-POSITION: -15px -75px } .x-tool-close { BACKGROUND-POSITION: 0px 0px } .x-tool-close-over { BACKGROUND-POSITION: -15px 0px } .x-tool-minimize { BACKGROUND-POSITION: 0px -15px } .x-tool-minimize-over { BACKGROUND-POSITION: -15px -15px } .x-tool-maximize { BACKGROUND-POSITION: 0px -30px } .x-tool-maximize-over { BACKGROUND-POSITION: -15px -30px } .x-tool-restore { BACKGROUND-POSITION: 0px -45px } .x-tool-restore-over { BACKGROUND-POSITION: -15px -45px } .x-tool-gear { BACKGROUND-POSITION: 0px -90px } .x-tool-gear-over { BACKGROUND-POSITION: -15px -90px } .x-tool-pin { BACKGROUND-POSITION: 0px -135px } .x-tool-pin-over { BACKGROUND-POSITION: -15px -135px } .x-tool-unpin { BACKGROUND-POSITION: 0px -150px } .x-tool-unpin-over { BACKGROUND-POSITION: -15px -150px } .x-tool-right { BACKGROUND-POSITION: 0px -165px } .x-tool-right-over { BACKGROUND-POSITION: -15px -165px } .x-tool-left { BACKGROUND-POSITION: 0px -180px } .x-tool-left-over { BACKGROUND-POSITION: -15px -180px } .x-tool-up { BACKGROUND-POSITION: 0px -210px } .x-tool-up-over { BACKGROUND-POSITION: -15px -210px } .x-tool-down { BACKGROUND-POSITION: 0px -195px } .x-tool-down-over { BACKGROUND-POSITION: -15px -195px } .x-tool-refresh { BACKGROUND-POSITION: 0px -225px } .x-tool-refresh-over { BACKGROUND-POSITION: -15px -225px } .x-tool-minus { BACKGROUND-POSITION: 0px -255px } .x-tool-minus-over { BACKGROUND-POSITION: -15px -255px } .x-tool-plus { BACKGROUND-POSITION: 0px -240px } .x-tool-plus-over { BACKGROUND-POSITION: -15px -240px } .x-tool-search { BACKGROUND-POSITION: 0px -270px } .x-tool-search-over { BACKGROUND-POSITION: -15px -270px } .x-tool-save { BACKGROUND-POSITION: 0px -285px } .x-tool-save-over { BACKGROUND-POSITION: -15px -285px } .x-tool-help { BACKGROUND-POSITION: 0px -300px } .x-tool-help-over { BACKGROUND-POSITION: -15px -300px } .x-tool-print { BACKGROUND-POSITION: 0px -315px } .x-tool-print-over { BACKGROUND-POSITION: -15px -315px } .x-panel-ghost { Z-INDEX: 12000; BACKGROUND: #cbddf3; FILTER: alpha(opacity=3D65); LEFT: = 0px; OVERFLOW: hidden; POSITION: absolute; TOP: 0px; opacity: .65; = -moz-opacity: .65 } .x-panel-ghost UL { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #99bbe8 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; LINE-HEIGHT: 0; PADDING-TOP: 0px; BORDER-BOTTOM: #99bbe8 1px = solid } .x-panel-ghost * { CURSOR: move! important } .x-panel-dd-spacer { BORDER-RIGHT: #99bbe8 2px dashed; BORDER-TOP: #99bbe8 2px dashed; = BORDER-LEFT: #99bbe8 2px dashed; BORDER-BOTTOM: #99bbe8 2px dashed } .x-panel-btns-ct { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } .x-panel-btns-ct .x-btn { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns TD { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-btns-ct .x-panel-btns-right TABLE { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns-left TABLE { CLEAR: none; FLOAT: left } .x-panel-btns-ct .x-panel-btns-center { TEXT-ALIGN: center } .x-panel-btns-ct .x-panel-btns-center TABLE { MARGIN: 0px auto } .x-panel-btns-ct TABLE TD.x-panel-btn-td { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } .x-panel-btns-ct .x-btn-focus .x-btn-left { BACKGROUND-POSITION: 0px -147px } .x-panel-btns-ct .x-btn-focus .x-btn-right { BACKGROUND-POSITION: 0px -168px } .x-panel-btns-ct .x-btn-focus .x-btn-center { BACKGROUND-POSITION: 0px -189px } .x-panel-btns-ct .x-btn-over .x-btn-left { BACKGROUND-POSITION: 0px -63px } .x-panel-btns-ct .x-btn-over .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-over .x-btn-center { BACKGROUND-POSITION: 0px -105px } .x-panel-btns-ct .x-btn-click .x-btn-center { BACKGROUND-POSITION: 0px -126px } .x-panel-btns-ct .x-btn-click .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-click .x-btn-left { BACKGROUND-POSITION: 0px -63px } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/core/ext.ncbi/1/css/themes/xtheme-oldentrez.css .x-panel { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-STYLE: solid; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-STYLE: = solid; BORDER-LEFT-STYLE: solid; BORDER-RIGHT-COLOR: #d0d0d0; = BORDER-BOTTOM-STYLE: solid } .x-panel-header { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND-IMAGE: url(../../img/oldentrez/panel/white-top-bottom.gif); = BORDER-LEFT: #d0d0d0 1px solid; COLOR: #333; BORDER-BOTTOM: #d0d0d0 1px = solid } .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar-noheader .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-body-noheader { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tl .x-panel-header { COLOR: #333 } .x-panel-tc { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/top-bottom.gif) } .x-panel-tl { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(../../img/oldentrez/panel/corners-sprite.gif); BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tr { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/corners-sprite.gif) } .x-panel-bc { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/top-bottom.gif) } .x-panel-bl { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/corners-sprite.gif) } .x-panel-br { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/corners-sprite.gif) } .x-panel-mc { BACKGROUND: #f1f1f1 } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/left-right.gif) } .x-panel-mr { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/left-right.gif) } .x-tool { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/tool-sprites.gif) } .x-panel-ghost { BACKGROUND: #e0e0e0 } .x-panel-ghost UL { BORDER-LEFT-COLOR: #b0b0b0; BORDER-BOTTOM-COLOR: #b0b0b0; = BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-grid-panel .x-panel-mc .x-panel-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #d0d0d0 1px solid } .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/button/btn-sprite.gif) } .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/button/btn-sprite.gif) } .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/button/btn-sprite.gif) } .x-border-layout-ct { BACKGROUND: #f0f0f0 } .x-accordion-hd { BACKGROUND-IMAGE: url(../../img/oldentrez/panel/light-hd.gif) } .x-layout-collapsed { BORDER-LEFT-COLOR: #e0e0e0; BORDER-BOTTOM-COLOR: #e0e0e0; = BORDER-TOP-COLOR: #e0e0e0; BACKGROUND-COLOR: #eee; BORDER-RIGHT-COLOR: = #e0e0e0 } .x-layout-collapsed-over { BACKGROUND-COLOR: #fbfbfb } .x-tip .x-tip-top { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-left { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-right { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-left { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-right { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-left { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-right { BACKGROUND-IMAGE: url(../../img/oldentrez/qtip/tip-sprite.gif) } .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(../../img/oldentrez/toolbar/bg.gif) #f0f4f5 repeat-x left top; = BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-toolbar BUTTON { COLOR: #444 } .x-toolbar .x-btn-menu-arrow-wrap .x-btn-center BUTTON { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-text-icon .x-btn-menu-arrow-wrap .x-btn-center BUTTON = { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-over .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over BUTTON { COLOR: #111 } .x-toolbar .x-btn-click .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-left { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-right { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-center { BACKGROUND-IMAGE: url(../../img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .ytb-sep { BACKGROUND-IMAGE: url(../images/default/grid/grid-split.gif) } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-top { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(../../img/oldentrez/tabs/tab-strip-bg.gif) #dbdbdb repeat-x left = top; BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = PADDING-TOP: 2px; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-bottom { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/tab-strip-btm-bg.gif); BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-strip SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-over SPAN.x-tab-strip-text { COLOR: #111 } .x-tab-strip-active SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-disabled .x-tabs-text { COLOR: #aaaaaa } .x-tab-strip-top .x-tab-right { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-left { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-strip-inner { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-bottom .x-tab-right { BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/tab-btm-inactive-right-bg.gif) } .x-tab-strip-bottom .x-tab-left { BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/tab-btm-inactive-left-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-right { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-btm-right-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-left { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-btm-left-bg.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-close.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close:hover { BACKGROUND-IMAGE: url(../../img/oldentrez/tabs/tab-close.gif) } .x-tab-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #fff; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header-plain .x-tab-strip-spacer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-scroller-left { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/scroll-left.gif); BORDER-BOTTOM-COLOR: = #aeaeae; BORDER-TOP-COLOR: #aeaeae; BORDER-RIGHT-COLOR: #aeaeae } .x-tab-scroller-right { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(../../img/oldentrez/tabs/scroll-right.gif); BORDER-BOTTOM-COLOR: = #aeaeae; BORDER-TOP-COLOR: #aeaeae; BORDER-RIGHT-COLOR: #aeaeae } .x-window-proxy { BORDER-LEFT-COLOR: #b0b0b0; BACKGROUND: #e0e0e0; BORDER-BOTTOM-COLOR: = #b0b0b0; BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-window-tl .x-window-header { COLOR: #555 } .x-window-tc { BACKGROUND-IMAGE: url(../../img/oldentrez/window/top-bottom.png) } .x-window-tl { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-corners.png) } .x-window-tr { BACKGROUND-IMAGE: url(../../img/oldentrez/window/right-corners.png) } .x-window-bc { BACKGROUND-IMAGE: url(../../img/oldentrez/window/top-bottom.png) } .x-window-bl { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-corners.png) } .x-window-br { BACKGROUND-IMAGE: url(../../img/oldentrez/window/right-corners.png) } .x-window-mc { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: = #d0d0d0 1px solid } .x-window-ml { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-right.png) } .x-window-mr { BACKGROUND-IMAGE: url(../../img/oldentrez/window/left-right.png) } .x-panel-ghost .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-collapsed .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-window-plain .x-window-mc { BORDER-RIGHT: #eee 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #eee = 1px solid } .x-window-plain .x-window-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #eee 1px solid; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-LEFT: #eee 1px = solid; BORDER-BOTTOM: #d0d0d0 1px solid } BODY.x-body-masked .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } BODY.x-body-masked .x-window-plain .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } .x-html-editor-wrap { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-noborder .x-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-noborder .x-window-mc { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-plain .x-window-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-footer-noborder { BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: = 0px } .x-tab-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-header { FONT-SIZE: 90%; FONT-FAMILY: Arial, Verdana, Sans-Serif; = BACKGROUND-COLOR: #e3e3e3; xbackground: none } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/portal/portalrc.fcgi/40468/css/40126/37583.css .footer { CLEAR: both } .dynamic_footer { FONT-SIZE: 62.5% } #footer { LINE-HEIGHT: 1.8em; FONT-FAMILY: "Helvetica Neue", GillSans, helvetica, = "lucida sans", arial, sans-serif } #NCBIFooter_dynamic { LINE-HEIGHT: 1.8em; FONT-FAMILY: "Helvetica Neue", GillSans, helvetica, = "lucida sans", arial, sans-serif } #footer H3 { FONT-SIZE: 1.1em; COLOR: #505050 } .foot_list H3 { FONT-SIZE: 1.1em } #footer { FONT-SIZE: 1.1em } #NCBIFooter_dynamic { CLEAR: both; FONT-SIZE: 1.1em; Z-INDEX: 10; COLOR: #505050; POSITION: = relative; TOP: 2.5em; _top: -1.5em } .breadcrumbs { LEFT: 1.6em; POSITION: absolute; TOP: 1.1em } .help_desk { RIGHT: 1em; POSITION: absolute; TOP: 1.1em } #NCBIFooter_dynamic A { COLOR: #14376c; TEXT-DECORATION: none } #footer A { COLOR: #14376c; TEXT-DECORATION: none } #NCBIFooter_dynamic A:hover { TEXT-DECORATION: underline; BORDER-BOTTOM-STYLE: none } #footer A:hover { TEXT-DECORATION: underline; BORDER-BOTTOM-STYLE: none } .contact_info A:hover { TEXT-DECORATION: underline; BORDER-BOTTOM-STYLE: none } #footer-contents-right { FLOAT: right; TEXT-ALIGN: right; _margin-top: 1em } #footer-contents-right A { PADDING-LEFT: 2px; FLOAT: left; OVERFLOW: hidden; WIDTH: 50px; = TEXT-INDENT: 10em; PADDING-TOP: 14px; HEIGHT: 41px } #footer-contents-right A.nih_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/nih_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 48px } #footer-contents-right A.nlm_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/nlm_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 50px } #footer-contents-right A.dhhs_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/dhhs_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 49px } #footer-contents-right A.usagov_img_link { BACKGROUND: url(/coreweb/images/ncbi/footer/usagov_logo_footer.gif) = no-repeat 0pt 100%; WIDTH: 94px } #footer-contents-left { =09 } #footer-contents-left P.address { MARGIN: 0px; PADDING-TOP: 1px } #footer-contents-left P.updateinfo { MARGIN: 1px; PADDING-TOP: 12px; TEXT-ALIGN: right } #footer-contents-left A { FONT-WEIGHT: bold } #footer-contents-left P.address .adr { DISPLAY: block } #footer-contents-left P.address .url { FONT-WEIGHT: normal; MARGIN: 0px } #footer { CLEAR: both; Z-INDEX: 1; BACKGROUND: = url(/portal/portalrc.fcgi/40468/img/38528) #e5e5e5 repeat-x left top; = ZOOM: 1; POSITION: relative; TOP: 2.5em; _margin-top: -4em } .crest { BACKGROUND: url(/portal/portalrc.fcgi/40468/img/31299) no-repeat left = top; LEFT: 46.8%; WIDTH: 50px; POSITION: absolute; TOP: -2.3em; HEIGHT: = 50px; _background-image: none } #footer { OVERFLOW: visible; COLOR: #14376c; BACKGROUND-COLOR: #fff; TEXT-ALIGN: = center } .contact_info { OVERFLOW: visible; COLOR: #14376c; BACKGROUND-COLOR: #fff; TEXT-ALIGN: = center } .foot_list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4em 0px 0px; WIDTH: 19%; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } .foot_list LI H3 { MARGIN: 0px 0px 0.05em; TEXT-TRANSFORM: uppercase } .contact_info { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 1.6em; BACKGROUND: = url(/portal/portalrc.fcgi/40468/img/31297) repeat-y left top; = PADDING-BOTTOM: 0.6em; PADDING-TOP: 0.3em; ZOOM: 1; POSITION: relative; = TOP: 0.6em; TEXT-ALIGN: left; _padding-bottom: 5em } .subfooter { MARGIN-LEFT: 1.6em } #footer-contents-left SPAN.url A { FONT-WEIGHT: normal } .offscreen_noflow { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; TEXT-INDENT: -9999em; PADDING-TOP: 0px; HEIGHT: 0px } #footer { MARGIN-BOTTOM: 6em } .universal_header .inline_list LI A { FONT-SIZE: 1.2em } .myncbi A { FONT-SIZE: 1.2em } .universal_header { FONT-FAMILY: "Helvetica Neue", GillSans, helvetica, "lucida sans", = arial, sans-serif; HEIGHT: 2.7em; BACKGROUND-COLOR: #369; _font-size: = 1em } UL.resources_list { MARGIN-LEFT: 1.3em } .myncbi A { COLOR: #fff; TEXT-DECORATION: none } .myncbi A:hover { TEXT-DECORATION: underline } #ncbihome:focus { BACKGROUND: none transparent scroll repeat 0% 0% } .myncbi { RIGHT: 1em; FLOAT: right; COLOR: #fff; POSITION: relative; TOP: 0.3em } .myncbi A { MARGIN-LEFT: 0.6em } #ncbihome { PADDING-RIGHT: 0.8em; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #fff; PADDING-TOP: 0.25em } BODY UL.jig-ncbimenu A:focus { =09 } UL.jig-ncbimenu A.topanchor { COLOR: #fff } UL.jig-ncbimenu A:hover { TEXT-DECORATION: none } .ui-ncbimenu-item-no-hlt { =09 } DIV.universal_header UL.jig-ncbimenu LI A { FONT-SIZE: 1.09em } .ui-ncbimenu-item { BORDER-BOTTOM: #e5e5e5 1px dotted; BACKGROUND-COLOR: #fcfcfc } .ui-ncbimenu LI.ui-ncbimenu-item-first = A.ui-ncbimenu-first-link-has-submenu { PADDING-RIGHT: 20px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0.2em; = PADDING-TOP: 0.5em } BODY UL.ui-ncbimenu-submenu { BORDER-RIGHT: #aaa 1px solid; BORDER-TOP: #ddd 1px solid; BORDER-LEFT: = #ddd 1px solid; BORDER-BOTTOM: #aaa 1px solid; box-shadow: .4em .4em = .5em #bbb; -webkit-box-shadow: .4em .4em .5em #bbb; -moz-box-shadow: = .4em .4em .5em #bbb } BODY .ui-ncbimenu-item-first-active { COLOR: #fff; BACKGROUND-COLOR: #4c96df } BODY UL LI A.ui-ncbimenu-item-active { COLOR: #fff; BACKGROUND-COLOR: #4c96df } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/portal/portalrc.fcgi/40595/css/39335/37572/25667/26519/22392/22398/25875/17551/22162/22394/28890/29899/17591/26330/25569/29286/38787/37650/27687/38781.css BODY { =09 } #pagewrap { MARGIN: auto; WIDTH: 960px; xborder: solid 1px red } #page { FONT-SIZE: 11pt; MARGIN: 1em } #footer { CLEAR: both; MIN-WIDTH: 800px; FONT-SIZE: 70%; PADDING-TOP: 1em } #NCBIFooter_dynamic { FONT-SIZE: 1.12em } #pmc-home-hdr { HEIGHT: 73px } #pmc-home-hdr #homelink { FLOAT: left } #pmc-home-hdr #homelink IMG { BORDER-TOP-STYLE: none; BORDER-RIGHT-STYLE: none; BORDER-LEFT-STYLE: = none; BORDER-BOTTOM-STYLE: none } #pmc-home-hdr H1 { MARGIN: 0px 0px 0px 144px; ZOOM: 1; FONT-FAMILY: Arial, Verdana, = Sans-Serif; POSITION: relative; TOP: -1px; BACKGROUND-COLOR: #3c78bc } #pmc-home-hdr UL { MARGIN: 0px 0px 0px 144px; ZOOM: 1; FONT-FAMILY: Arial, Verdana, = Sans-Serif; POSITION: relative; TOP: -1px; BACKGROUND-COLOR: #3c78bc } #pmc-home-hdr H1 { PADDING-RIGHT: 2em; BORDER-TOP: transparent 2px solid; FONT-SIZE: 2em; = COLOR: white; LINE-HEIGHT: 52px; TEXT-ALIGN: right } #pmc-home-hdr UL { BORDER-RIGHT: #3c78bc 1px solid; BORDER-BOTTOM: #3c78bc 3px solid; = HEIGHT: 18px; BACKGROUND-COLOR: #a0c0e0 } #pmc-home-hdr UL LI { PADDING-RIGHT: 40px; DISPLAY: inline; PADDING-LEFT: 40px; FONT-SIZE: = 1.3em; PADDING-BOTTOM: 0px; MARGIN: 0px; LINE-HEIGHT: 18px; PADDING-TOP: = 0px; LIST-STYLE-TYPE: none } #pmc-home-hdr UL LI A { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 2px; = PADDING-TOP: 2px; TEXT-DECORATION: none } #pmc-home-hdr UL LI A:hover { TEXT-DECORATION: underline } A:visited { COLOR: #7119b4 } #pmc-home-hdr UL LI.sel A { FONT-WEIGHT: bold; COLOR: white; BACKGROUND-COLOR: #3c78bc; = TEXT-DECORATION: none } #pmc-home-hdr UL LI.sel A:visited { FONT-WEIGHT: bold; COLOR: white; BACKGROUND-COLOR: #3c78bc; = TEXT-DECORATION: none } #pmc-home-hdr UL LI.sel A:hover { FONT-WEIGHT: bold; COLOR: white; BACKGROUND-COLOR: #3c78bc; = TEXT-DECORATION: none } .footer-section { MARGIN: 0px 1em 1em; TEXT-ALIGN: center } BODY #cols { BORDER-RIGHT: transparent 1px solid; BORDER-TOP: transparent 1px solid; = BORDER-LEFT: transparent 1px solid; BORDER-BOTTOM: transparent 1px solid } @media Print =20 { .footer { DISPLAY: none } TD.pmc-watermark { MIN-WIDTH: 0px; WIDTH: 0px } .issue-block { BORDER-COLLAPSE: collapse } .iss-cell { BORDER-RIGHT: black 1px solid; BORDER-TOP: black 1px solid; = BORDER-LEFT: black 1px solid; BORDER-BOTTOM: black 1px solid } .vol-cell { BORDER-RIGHT: black 1px solid; BORDER-TOP: black 1px solid; = BORDER-LEFT: black 1px solid; BORDER-BOTTOM: black 1px solid } } .nopagesectioncontent { DISPLAY: none } .port { FONT-SIZE: 1em } .port { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port OL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H5 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port H6 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port PRE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port FIELDSET { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port INPUT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port BLOCKQUOTE { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port TH { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port TD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .port IMG { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .port OL { LIST-STYLE-TYPE: none } .port UL { LIST-STYLE-TYPE: none } .x-unselectable { -moz-user-select: none; -khtml-user-select: none } .x-unselectable * { -moz-user-select: none; -khtml-user-select: none } .x-panel { BORDER-RIGHT: #99bbe8 0px solid; BORDER-TOP: #99bbe8 0px solid; = BORDER-LEFT: #99bbe8 0px solid; BORDER-BOTTOM: #99bbe8 0px solid } .x-panel-header { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #99bbe8 1px solid; PADDING-LEFT: 5px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/white-top-bottom.g= if) repeat-x 0px -1px; PADDING-BOTTOM: 4px; FONT: bold 11px/15px = tahoma,arial,verdana,sans-serif; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: #99bbe8 1px = solid; ZOOM: 1 } .x-panel-body { BORDER-RIGHT: #99bbe8 1px solid; BORDER-TOP: #99bbe8 0px; BACKGROUND: = white; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 1px solid; BORDER-BOTTOM: = #99bbe8 1px solid; POSITION: relative } .x-panel-bbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar .x-toolbar { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #99bbe8 0px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = BORDER-LEFT: #99bbe8 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #99bbe8 = 1px solid } .x-panel-tbar-noheader .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-TOP: #99bbe8 1px solid; BORDER-BOTTOM: 0px } .x-panel-body-noheader { BORDER-TOP: #99bbe8 1px solid } .x-panel-mc .x-panel-body { BORDER-TOP: #99bbe8 1px solid } .x-panel-header { OVERFLOW: hidden; ZOOM: 1 } .x-panel-tl .x-panel-header { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: none transparent scroll repeat 0% 0%; PADDING-BOTTOM: = 4px; FONT: bold 11px tahoma,arial,verdana,sans-serif; BORDER-LEFT: 0px; = COLOR: #15428b; PADDING-TOP: 5px; BORDER-BOTTOM: 0px } .x-panel-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-window-tl .x-panel-icon { BACKGROUND-POSITION: 0px 4px; PADDING-LEFT: 20px! important; = BACKGROUND-REPEAT: no-repeat; ZOOM: 1 } .x-panel-inline-icon { BACKGROUND-POSITION: 0px 0px; MARGIN-TOP: -1px; MARGIN-BOTTOM: -1px; = VERTICAL-ALIGN: middle; WIDTH: 16px; MARGIN-RIGHT: 4px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px } .x-panel-tc { BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/top-bottom.gif) = repeat-x 0px 0px; OVERFLOW: hidden } .ext-strict .ext-ie7 .x-panel-tc { OVERFLOW: visible } .x-panel-tl { PADDING-LEFT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat 0px 0px; BORDER-BOTTOM: #99bbe8 1px solid; ZOOM: 1 } .x-panel-tr { PADDING-RIGHT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat right 0px; ZOOM: 1 } .x-panel-bc { BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/top-bottom.gif) = repeat-x 0px bottom; ZOOM: 1 } .x-panel-bc .x-panel-footer { ZOOM: 1 } .x-panel-bl { PADDING-LEFT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat 0px bottom; ZOOM: 1 } .x-panel-br { PADDING-RIGHT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/corners-sprite.gif= ) no-repeat right bottom; ZOOM: 1 } .x-panel-mc { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; BACKGROUND: #dfe8f6; PADDING-BOTTOM: 0px; MARGIN: 0px; FONT: 11px = tahoma,arial,helvetica,sans-serif; BORDER-LEFT: 0px; PADDING-TOP: 6px; = BORDER-BOTTOM: 0px } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { PADDING-LEFT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/left-right.gif) = #fff repeat-y 0px 0px; ZOOM: 1 } .x-panel-mr { PADDING-RIGHT: 6px; BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/left-right.gif) = repeat-y right 0px; ZOOM: 1 } .x-panel-bc .x-panel-footer { PADDING-BOTTOM: 6px } .x-panel-nofooter .x-panel-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-nofooter .x-window-bc { FONT-SIZE: 0px; LINE-HEIGHT: 0; HEIGHT: 6px } .x-panel-bwrap { OVERFLOW: hidden; ZOOM: 1 } .x-panel-body { OVERFLOW: hidden; ZOOM: 1 } .x-panel-collapsed .x-resizable-handle { DISPLAY: none } .ext-gecko .x-panel-animated DIV { OVERFLOW: hidden! important } .x-plain-body { OVERFLOW: hidden } .x-plain-bbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-tbar .x-toolbar { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = hidden; PADDING-TOP: 2px } .x-plain-bwrap { OVERFLOW: hidden; ZOOM: 1 } .x-plain { OVERFLOW: hidden } .x-tool { BACKGROUND: = url(/core/extjs/ext-2.1/resources/images/default/panel/tool-sprites.gif) = no-repeat; FLOAT: right; MARGIN-LEFT: 2px; OVERFLOW: hidden; WIDTH: = 15px; CURSOR: pointer; HEIGHT: 15px } .x-tool-toggle { BACKGROUND-POSITION: 0px -60px } .x-tool-toggle-over { BACKGROUND-POSITION: -15px -60px } .x-panel-collapsed .x-tool-toggle { BACKGROUND-POSITION: 0px -75px } .x-panel-collapsed .x-tool-toggle-over { BACKGROUND-POSITION: -15px -75px } .x-tool-close { BACKGROUND-POSITION: 0px 0px } .x-tool-close-over { BACKGROUND-POSITION: -15px 0px } .x-tool-minimize { BACKGROUND-POSITION: 0px -15px } .x-tool-minimize-over { BACKGROUND-POSITION: -15px 50% } .x-tool-maximize { BACKGROUND-POSITION: 0px -30px } .x-tool-maximize-over { BACKGROUND-POSITION: -15px -30px } .x-tool-restore { BACKGROUND-POSITION: 0px -45px } .x-tool-restore-over { BACKGROUND-POSITION: -15px -45px } .x-tool-gear { BACKGROUND-POSITION: 0px -90px } .x-tool-gear-over { BACKGROUND-POSITION: -15px -90px } .x-tool-pin { BACKGROUND-POSITION: 0px -135px } .x-tool-pin-over { BACKGROUND-POSITION: -15px -135px } .x-tool-unpin { BACKGROUND-POSITION: 0px -150px } .x-tool-unpin-over { BACKGROUND-POSITION: -15px -150px } .x-tool-right { BACKGROUND-POSITION: 0px -165px } .x-tool-right-over { BACKGROUND-POSITION: -15px -165px } .x-tool-left { BACKGROUND-POSITION: 0px -180px } .x-tool-left-over { BACKGROUND-POSITION: -15px -180px } .x-tool-up { BACKGROUND-POSITION: 0px -210px } .x-tool-up-over { BACKGROUND-POSITION: -15px -210px } .x-tool-down { BACKGROUND-POSITION: 0px -195px } .x-tool-down-over { BACKGROUND-POSITION: -15px -195px } .x-tool-refresh { BACKGROUND-POSITION: 0px -225px } .x-tool-refresh-over { BACKGROUND-POSITION: -15px -225px } .x-tool-minus { BACKGROUND-POSITION: 0px -255px } .x-tool-minus-over { BACKGROUND-POSITION: -15px -255px } .x-tool-plus { BACKGROUND-POSITION: 0px -240px } .x-tool-plus-over { BACKGROUND-POSITION: -15px -240px } .x-tool-search { BACKGROUND-POSITION: 0px -270px } .x-tool-search-over { BACKGROUND-POSITION: -15px -270px } .x-tool-save { BACKGROUND-POSITION: 0px -285px } .x-tool-save-over { BACKGROUND-POSITION: -15px -285px } .x-tool-help { BACKGROUND-POSITION: 0px -300px } .x-tool-help-over { BACKGROUND-POSITION: -15px -300px } .x-tool-print { BACKGROUND-POSITION: 0px -315px } .x-tool-print-over { BACKGROUND-POSITION: -15px -315px } .x-panel-ghost { Z-INDEX: 12000; BACKGROUND: #cbddf3; FILTER: alpha(opacity=3D65); LEFT: = 0px; OVERFLOW: hidden; POSITION: absolute; TOP: 0px; opacity: .65; = -moz-opacity: .65 } .x-panel-ghost UL { BORDER-RIGHT: #99bbe8 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #99bbe8 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; OVERFLOW: hidden; BORDER-LEFT: #99bbe8 = 1px solid; LINE-HEIGHT: 0; PADDING-TOP: 0px; BORDER-BOTTOM: #99bbe8 1px = solid } .x-panel-ghost * { CURSOR: move! important } .x-panel-dd-spacer { BORDER-RIGHT: #99bbe8 2px dashed; BORDER-TOP: #99bbe8 2px dashed; = BORDER-LEFT: #99bbe8 2px dashed; BORDER-BOTTOM: #99bbe8 2px dashed } .x-panel-btns-ct { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } .x-panel-btns-ct .x-btn { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns TD { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-btns-ct .x-panel-btns-right TABLE { CLEAR: none; FLOAT: right } .x-panel-btns-ct .x-panel-btns-left TABLE { CLEAR: none; FLOAT: left } .x-panel-btns-ct .x-panel-btns-center { TEXT-ALIGN: center } .x-panel-btns-ct .x-panel-btns-center TABLE { MARGIN: 0px auto } .x-panel-btns-ct TABLE TD.x-panel-btn-td { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } .x-panel-btns-ct .x-btn-focus .x-btn-left { BACKGROUND-POSITION: 0px -147px } .x-panel-btns-ct .x-btn-focus .x-btn-right { BACKGROUND-POSITION: 0px -168px } .x-panel-btns-ct .x-btn-focus .x-btn-center { BACKGROUND-POSITION: 0px -189px } .x-panel-btns-ct .x-btn-over .x-btn-left { BACKGROUND-POSITION: 0px -63px } .x-panel-btns-ct .x-btn-over .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-over .x-btn-center { BACKGROUND-POSITION: 0px -105px } .x-panel-btns-ct .x-btn-click .x-btn-center { BACKGROUND-POSITION: 0px -126px } .x-panel-btns-ct .x-btn-click .x-btn-right { BACKGROUND-POSITION: 0px -84px } .x-panel-btns-ct .x-btn-click .x-btn-left { BACKGROUND-POSITION: 0px -63px } .x-btn-menu-wrap { WIDTH: 0px! important } .x-menu { BACKGROUND: #f0f0f0 0px 0px } .x-menu-list-item IMG { DISPLAY: none } .x-menu-list-item A.x-menu-item { PADDING-LEFT: 8px } .port H1.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H2.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H3.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H4.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H5.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } .port H6.x-panel-header-text { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } DIV.x-panel-body { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px } .port .x-panel-header { PADDING-RIGHT: 3px; PADDING-LEFT: 5px; PADDING-BOTTOM: 4px; = PADDING-TOP: 5px } .x-panel { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-STYLE: solid; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-STYLE: = solid; BORDER-LEFT-STYLE: solid; BORDER-RIGHT-COLOR: #d0d0d0; = BORDER-BOTTOM-STYLE: solid } .x-panel-header { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/white-top-bottom.gif); = BORDER-LEFT: #d0d0d0 1px solid; COLOR: #333; BORDER-BOTTOM: #d0d0d0 1px = solid } .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tbar-noheader .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-body-noheader { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-mc .x-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tl .x-panel-header { COLOR: #333 } .x-panel-tc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/top-bottom.gif) } .x-panel-tl { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif); = BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-tr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif) } .x-panel-bc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/top-bottom.gif) } .x-panel-bl { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif) } .x-panel-br { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/corners-sprite.gif) } .x-panel-mc { BACKGROUND: #f1f1f1 } .x-panel-mc .x-panel-body { BORDER-RIGHT: 0px; BORDER-TOP: 0px; BACKGROUND: none transparent scroll = repeat 0% 0%; BORDER-LEFT: 0px; BORDER-BOTTOM: 0px } .x-panel-ml { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/left-right.gif) } .x-panel-mr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/left-right.gif) } .x-tool { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/tool-sprites.gif) } .x-panel-ghost { BACKGROUND: #e0e0e0 } .x-panel-ghost UL { BORDER-LEFT-COLOR: #b0b0b0; BORDER-BOTTOM-COLOR: #b0b0b0; = BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-grid-panel .x-panel-mc .x-panel-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #d0d0d0 1px solid } .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/button/btn-sprite.gif) } .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/button/btn-sprite.gif) } .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/button/btn-sprite.gif) } .x-border-layout-ct { BACKGROUND: #f0f0f0 } .x-accordion-hd { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/panel/light-hd.gif) } .x-layout-collapsed { BORDER-LEFT-COLOR: #e0e0e0; BORDER-BOTTOM-COLOR: #e0e0e0; = BORDER-TOP-COLOR: #e0e0e0; BACKGROUND-COLOR: #eee; BORDER-RIGHT-COLOR: = #e0e0e0 } .x-layout-collapsed-over { BACKGROUND-COLOR: #fbfbfb } .x-tip .x-tip-top { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-top-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-ft-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-tip .x-tip-bd-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/qtip/tip-sprite.gif) } .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/bg.gif) #f0f4f5 repeat-x left = top; BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-toolbar BUTTON { COLOR: #444 } .x-toolbar .x-btn-menu-arrow-wrap .x-btn-center BUTTON { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-text-icon .x-btn-menu-arrow-wrap .x-btn-center BUTTON = { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/btn-arrow.gif) } .x-toolbar .x-btn-over .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-over BUTTON { COLOR: #111 } .x-toolbar .x-btn-click .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-click .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-pressed .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .x-btn-menu-active .x-btn-center { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/toolbar/tb-btn-sprite.gif) } .x-toolbar .ytb-sep { BACKGROUND-IMAGE: = url(/core/extjs/ext-2.1/resources/images/default/grid/grid-split.gif) } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-footer { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-top { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-strip-bg.gif) #dbdbdb = repeat-x left top; BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: = #d0d0d0; PADDING-TOP: 2px; BORDER-RIGHT-COLOR: #d0d0d0 } UL.x-tab-strip-bottom { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-strip-btm-bg.gif); = BORDER-BOTTOM-COLOR: #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; = BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-strip SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-over SPAN.x-tab-strip-text { COLOR: #111 } .x-tab-strip-active SPAN.x-tab-strip-text { COLOR: #333 } .x-tab-strip-disabled .x-tabs-text { COLOR: #aaaaaa } .x-tab-strip-top .x-tab-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-top .x-tab-strip-inner { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tabs-sprite.gif) } .x-tab-strip-bottom .x-tab-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-inactive-right-bg.gif) } .x-tab-strip-bottom .x-tab-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-inactive-left-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-right { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-right-bg.gif) } .x-tab-strip-bottom .x-tab-strip-active .x-tab-left { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-btm-left-bg.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-close.gif) } .x-tab-strip .x-tab-strip-closable A.x-tab-strip-close:hover { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/tab-close.gif) } .x-tab-panel-body { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #fff; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-bbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-tbar .x-toolbar { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-panel-header-plain .x-tab-strip-spacer { BORDER-LEFT-COLOR: #d0d0d0; BACKGROUND: #eaeaea; BORDER-BOTTOM-COLOR: = #d0d0d0; BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-tab-scroller-left { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/scroll-left.gif); = BORDER-BOTTOM-COLOR: #aeaeae; BORDER-TOP-COLOR: #aeaeae; = BORDER-RIGHT-COLOR: #aeaeae } .x-tab-scroller-right { BORDER-LEFT-COLOR: #aeaeae; BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/tabs/scroll-right.gif); = BORDER-BOTTOM-COLOR: #aeaeae; BORDER-TOP-COLOR: #aeaeae; = BORDER-RIGHT-COLOR: #aeaeae } .x-window-proxy { BORDER-LEFT-COLOR: #b0b0b0; BACKGROUND: #e0e0e0; BORDER-BOTTOM-COLOR: = #b0b0b0; BORDER-TOP-COLOR: #b0b0b0; BORDER-RIGHT-COLOR: #b0b0b0 } .x-window-tl .x-window-header { COLOR: #555 } .x-window-tc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/top-bottom.png) } .x-window-tl { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-corners.png) } .x-window-tr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/right-corners.png) } .x-window-bc { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/top-bottom.png) } .x-window-bl { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-corners.png) } .x-window-br { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/right-corners.png) } .x-window-mc { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: = #d0d0d0 1px solid } .x-window-ml { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-right.png) } .x-window-mr { BACKGROUND-IMAGE: = url(/core/ext.ncbi/1/img/oldentrez/window/left-right.png) } .x-panel-ghost .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-collapsed .x-window-tl { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-window-plain .x-window-mc { BORDER-RIGHT: #eee 1px solid; BORDER-TOP: #d0d0d0 1px solid; = BACKGROUND: #e8e8e8; BORDER-LEFT: #d0d0d0 1px solid; BORDER-BOTTOM: #eee = 1px solid } .x-window-plain .x-window-body { BORDER-RIGHT: #d0d0d0 1px solid; BORDER-TOP: #eee 1px solid; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-LEFT: #eee 1px = solid; BORDER-BOTTOM: #d0d0d0 1px solid } BODY.x-body-masked .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } BODY.x-body-masked .x-window-plain .x-window-mc { BACKGROUND-COLOR: #e4e4e4 } .x-html-editor-wrap { BORDER-LEFT-COLOR: #d0d0d0; BORDER-BOTTOM-COLOR: #d0d0d0; = BORDER-TOP-COLOR: #d0d0d0; BORDER-RIGHT-COLOR: #d0d0d0 } .x-panel-noborder .x-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-noborder .x-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-noborder .x-window-mc { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-window-plain .x-window-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-body-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-header-noborder { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-noborder .x-tab-panel-footer-noborder { BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: = 0px } .x-tab-panel-bbar-noborder .x-toolbar { BORDER-TOP: #d0d0d0 1px solid; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px } .x-tab-panel-tbar-noborder .x-toolbar { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM: #d0d0d0 = 1px solid; BORDER-RIGHT-WIDTH: 0px } .x-panel-header { FONT-SIZE: 90%; FONT-FAMILY: Arial, Verdana, Sans-Serif; = BACKGROUND-COLOR: #e3e3e3; xbackground: none } DIV.section.port { MARGIN-TOP: 0.5em; PADDING-TOP: 0.5em; FONT-FAMILY: = Arial,Helvetica,Sans-Serif } DIV.x-panel-body DIV.section.port { MARGIN-TOP: 0px; PADDING-TOP: 0px } DIV.section.port DIV.window { PADDING-LEFT: 0.5em; MARGIN-BOTTOM: 0.5em } DIV.port LI.item EM.error.linklist { FONT-SIZE: 1.2em; COLOR: #cc0000; BACKGROUND-COLOR: #eaebc8 } DIV.norender.port { FONT-FAMILY: Arial,Lucida Sans,Trebuchet,Sans-Serif } DIV.brieflink { MARGIN-TOP: 0.5em; PADDING-TOP: 0.5em; FONT-FAMILY: Arial, Lucida Sans, = Trebuchet, Sans-Serif } DIV.brieflink H2 { FONT-WEIGHT: bold; FONT-SIZE: 0.8em; PADDING-BOTTOM: 0.3em; = MARGIN-LEFT: 0.2em; COLOR: #000000 } DIV.brieflink DIV { BORDER-TOP: #bdbdbd 1px solid } DIV.brieflink UL { FONT-SIZE: 0.8em; COLOR: #212121 } DIV.brieflink UL LI.item { BACKGROUND-POSITION: 0px 0.35em; PADDING-LEFT: 1.2em; MIN-HEIGHT: = 1.25em; BACKGROUND-IMAGE: url(/portal/portalrc.fcgi/40595/img/28247); = MARGIN: 0.25em 0px 0px; OVERFLOW: hidden; MAX-HEIGHT: 2.5em; = LINE-HEIGHT: 1.25em; PADDING-TOP: 0.1em; BACKGROUND-REPEAT: no-repeat; = ZOOM: 1; POSITION: relative } DIV.brieflink UL LI.note.item { HEIGHT: 2.5em } DIV.brieflink UL LI.more { MARGIN-TOP: 0.5em; PADDING-TOP: 0.1em; WHITE-SPACE: nowrap; TEXT-ALIGN: = right; BORDER-BOTTOM-STYLE: none } DIV.brieflink UL LI.item A { FLOAT: left; OVERFLOW: hidden; COLOR: #212121; MAX-HEIGHT: 2.5em; = TEXT-DECORATION: none; BORDER-BOTTOM-STYLE: none } DIV.brieflink UL LI.more A { COLOR: #212121; TEXT-DECORATION: none; BORDER-BOTTOM-STYLE: none } DIV.brieflink UL LI A:hover { TEXT-DECORATION: underline; _border-bottom: none } DIV.brieflink LI.item P.desc { LEFT: 1000px; BOTTOM: 1000px; LINE-HEIGHT: 0; POSITION: relative; = HEIGHT: 0px } DIV.brieflink UL LI.item P.note { DISPLAY: inline; PADDING-LEFT: 0.2em; RIGHT: 0px; OVERFLOW: hidden; = COLOR: #666666; WHITE-SPACE: nowrap; POSITION: absolute; TOP: 1.3em; = BACKGROUND-COLOR: white } DIV.brieflink LI.footer { BORDER-TOP: #bdbdbd 1px solid; MARGIN-TOP: 0.4em; FONT-SIZE: 0.9em; = MARGIN-LEFT: 1.5em; COLOR: #666666; LINE-HEIGHT: 1.5em; TEXT-ALIGN: = right } .poptext { DISPLAY: none } .popper { DISPLAY: none; Z-INDEX: 1000; MARGIN: 0px; WIDTH: 300px; ZOOM: 1; = POSITION: absolute } .pop-getxy { DISPLAY: none; Z-INDEX: 1000; MARGIN: 0px; WIDTH: 300px; ZOOM: 1; = POSITION: absolute } .port { ZOOM: 1! important } .pop-getxy { VISIBILITY: hidden } .popped.popper { DISPLAY: block; BACKGROUND-COLOR: #fff } DIV.pop-left.popped.popper DIV.popperInnerDiv { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 0px } DIV.pop-right.popped.popper DIV.popperInnerDiv { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; MARGIN-RIGHT: 0px } DIV.pop-above.popped.popper DIV.popperInnerDiv { MARGIN-TOP: 0px; MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } DIV.pop-below.popped.popper DIV.popperInnerDiv { MARGIN-BOTTOM: 0px; MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } .popper { FONT-SIZE: 0.8em; WIDTH: 30em; COLOR: #222; FONT-FAMILY: Arial, Lucida = Sans, Trebuchet, Sans-Serif } .popped.popper { BACKGROUND: url(/portal/portalrc.fcgi/40595/img/17684) no-repeat center = center; xbackground: transparent = url(http://iwebdev/staff/mjohnson/proj/components/popper/pop2.png) = no-repeat center center } .popped.popper DIV.popperInnerDiv { BORDER-RIGHT: #369 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #369 = 1px solid; PADDING-LEFT: 0.5em; PADDING-BOTTOM: 0.5em; MARGIN: 15px; = BORDER-LEFT: #369 1px solid; PADDING-TOP: 0.5em; BORDER-BOTTOM: #369 1px = solid; BACKGROUND-COLOR: #f0f8ff } DIV#popContent DIV.popperInnerDiv { PADDING-RIGHT: 0.5em; PADDING-LEFT: 0.5em; FONT-SIZE: 80%; Z-INDEX: 5; = PADDING-BOTTOM: 0.5em; COLOR: #444444; PADDING-TOP: 0.5em; FONT-FAMILY: = Verdana, Arial, sans-serif; BACKGROUND-COLOR: #f0f8ff; opacity: 1 } DIV.pop-left.popped.popper { BACKGROUND-POSITION: 100% -12px } DIV.pop-right.popped.popper { BACKGROUND-POSITION: 0px -12px } DIV.pop-above.popped.popper { BACKGROUND-POSITION: -12px 100% } DIV.pop-below.popped.popper { BACKGROUND-POSITION: -12px 0px } DIV.section DIV.window.brieflink { MARGIN-TOP: 0.75em; PADDING-TOP: 0px } DIV.window.brieflink UL LI.item { HEIGHT: auto } DIV#HTDisplay { FONT-FAMILY: Arial,sans-serif } DIV#HTDisplay A { COLOR: #232323; BORDER-TOP-STYLE: none; BORDER-RIGHT-STYLE: none; = BORDER-LEFT-STYLE: none; TEXT-DECORATION: underline; = BORDER-BOTTOM-STYLE: none } DIV#HTDisplay UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 80%; PADDING-BOTTOM: = 0px; MARGIN: 1.3em 0em 1em; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = _padding-top: 1.3em } DIV#HTDisplay UL LI { PADDING-RIGHT: 0.2em; PADDING-LEFT: 1.8em; MARGIN: 0.8em 0.3em 0.8em = 0.7em; OVERFLOW: hidden; COLOR: #232323; MAX-HEIGHT: 2.6em; POSITION: = relative; HEIGHT: auto } DIV#HTDisplay UL LI.query { MIN-HEIGHT: 15px; BACKGROUND: = url(/portal/portalrc.fcgi/40595/img/16134) no-repeat 0px 0px } DIV#HTDisplay UL LI.query DIV.textwrapper { MAX-WIDTH: 85% } DIV#HTDisplay UL LI.record { BACKGROUND: url(/portal/portalrc.fcgi/40595/img/16133) no-repeat 0px = 20%; LINE-HEIGHT: 1.3 } DIV#HTDisplay UL LI.bottomline { PADDING-BOTTOM: 0.3em; BORDER-BOTTOM: #999999 1px solid } DIV#HTDisplay UL LI A.hidden { DISPLAY: none } DIV#HTDisplay UL LI.record A { TEXT-DECORATION: none } DIV#HTDisplay UL LI.record A:hover { TEXT-DECORATION: underline } DIV#HTDisplay UL .count { LEFT: 0.3em; POSITION: relative; TOP: 1px } DIV#HTDisplay DIV.action { OVERFLOW: hidden } DIV#HTDisplay DIV.action A { FONT-SIZE: 75%; FLOAT: right; MARGIN: 0em 0.5em 0.25em } DIV#HTDisplay P { CLEAR: both; FONT-SIZE: 85%; MARGIN: 1.2em 0em 0.6em 0.5em } DIV#HTDisplay UL LI .thumb { RIGHT: 0px; PADDING-TOP: 0.4em; POSITION: absolute; BACKGROUND-COLOR: = white; _padding-right: 0.4em } DIV#HTDisplay P { DISPLAY: none } DIV#HTDisplay .action A.HTOff { DISPLAY: none } DIV.HTOff#HTDisplay .action A.HTOn { DISPLAY: none } DIV.HTOff#HTDisplay P.HTOff { DISPLAY: block } DIV.HTOn#HTDisplay P.HTOn { DISPLAY: block } DIV.HTOff#HTDisplay .action A.HTOff { DISPLAY: block } DIV.HTOn#HTDisplay .action A.HTOn { DISPLAY: block } DIV#HTDisplay UL.hide { DISPLAY: none } IMG.htbpoparrow { Z-INDEX: 4; BACKGROUND: url(/corehtml/query/PubMed/right.jpg) no-repeat = right top; LEFT: 22px; FLOAT: right; ZOOM: 1; POSITION: relative; TOP: = -7px; _left: 25px } DIV#htbpopper { BORDER-RIGHT: #369 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #369 = 1px solid; DISPLAY: block; PADDING-LEFT: 0.5em; FONT-SIZE: 80%; Z-INDEX: = 5; PADDING-BOTTOM: 0.5em; BORDER-LEFT: #369 1px solid; WIDTH: 32em; = COLOR: #444; PADDING-TOP: 0.5em; BORDER-BOTTOM: #369 1px solid; ZOOM: 1; = FONT-FAMILY: Verdana; POSITION: absolute; BACKGROUND-COLOR: #f0f8ff; = opacity: 100 } DIV.popper P { MARGIN: 0px 0px 0.25em } P#htbpcit { DISPLAY: block; FONT-SIZE: 85% } P.pmid { DISPLAY: block; FONT-SIZE: 85% } P#htbpcit { FONT-STYLE: italic } .hidden#htbpopper { DISPLAY: none } DIV#HTDisplay UL LI SPAN.thumb { BACKGROUND-COLOR: #f8f8f8 } #content UL.DiscoverySection { =09 } #content LI.DiscoverySectionTitle { FONT-WEIGHT: bold; PADDING-BOTTOM: 0.2em; COLOR: #1356d8; PADDING-TOP: = 1em; BORDER-BOTTOM: #cccccc 1px solid } #content LI.DiscoveryItem { PADDING-LEFT: 1.2em; FONT-SIZE: 0.9em; BACKGROUND: = url(/portal/portalrc.fcgi/15049/img/15679) no-repeat left top; = PADDING-BOTTOM: 0.3em } #content LI.DiscoveryItem A { COLOR: #232323; BORDER-BOTTOM-STYLE: none } UNKNOWN { TEXT-DECORATION: underline } #content LI.DiscoveryAllLinks { FONT-SIZE: 0.9em; PADDING-BOTTOM: 0.3em; BORDER-BOTTOM: #cccccc 1px = solid; TEXT-ALIGN: right } #content LI.DiscoveryAllLinks A { COLOR: #cc0000; TEXT-DECORATION: underline } DIV.popper EM.cit { MARGIN-TOP: 0.5em; DISPLAY: block; FONT-SIZE: 0.85em; FONT-STYLE: = italic } DIV.popper EM.author { MARGIN-TOP: 0.5em; DISPLAY: block; FONT-SIZE: 0.85em; MARGIN-BOTTOM: = -0.3em; FONT-STYLE: normal } DIV.Pubmed_Discovery_RA SPAN.reviewflag { PADDING-RIGHT: 0.1em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; FONT-SIZE: 0.9em; FLOAT: left; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: middle; COLOR: white; MARGIN-RIGHT: 0.5em; PADDING-TOP: = 0px; FONT-STYLE: italic; BACKGROUND-COLOR: #a81b0e } DIV.popper SPAN.reviewflag { DISPLAY: none } DIV.PPMCPubmedRA SPAN.reviewflag { PADDING-RIGHT: 0.1em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; FONT-SIZE: 0.9em; FLOAT: left; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: middle; COLOR: white; MARGIN-RIGHT: 0.5em; PADDING-TOP: = 0px; FONT-STYLE: italic; BACKGROUND-COLOR: #a81b0e } DIV.popper SPAN.reviewflag { DISPLAY: none } BODY #col1 { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #col2 { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #subheader { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #subfooter { BORDER-RIGHT: #00c 1px solid; BORDER-TOP: #00c 1px solid; BORDER-LEFT: = #00c 1px solid; BORDER-BOTTOM: #00c 1px solid } BODY #subfooter { TEXT-ALIGN: center } #Table2 { WIDTH: 100%; BACKGROUND-COLOR: #ecf0f4 } TD.pmc-watermark { MIN-WIDTH: 20px; MIN-HEIGHT: auto } TD.format-menu { PADDING-RIGHT: 0px; PADDING-LEFT: 0.75em; FONT-SIZE: 80%; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } TD.format-menu UL { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0.25em; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 0.2em; PADDING-TOP: 0px } TD.format-menu H2 { DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 1em; COLOR: #000 } TD.format-menu UL LI { DISPLAY: inline; MARGIN: 0px 0.1em 0px 0px } TD.format-menu UL LI A { COLOR: #000000 } TD.format-menu UL LI.selected { COLOR: #5e5e5e } TD.content-cell > DIV TD.content-cell > DIV > DIV { ZOOM: 1 } TD.sidebar-cell { MIN-WIDTH: 250px; MAX-WIDTH: 350px; WIDTH: 350px } BODY.pmc-body #Table3 DIV.navlink-box { FONT-WEIGHT: normal; WIDTH: auto; BORDER-BOTTOM: #5e5e5e 1px solid } DIV.cited-ref { MIN-WIDTH: 250px; MAX-WIDTH: 350px; MARGIN: 0.3em 0.75em; WIDTH: 350px; = POSITION: absolute } DIV.section-content > DIV.p { WIDTH: 550px; WORD-WRAP: break-word } IMG.equation { MAX-WIDTH: 502px; ; WIDTH: expression(this.clientWidth - 2 < 500? = "auto" : "502px") } DIV.section-content DIV.figure-table-caption-in-article DIV.p { WIDTH: auto } DIV.ArticleRefDocsums { =09 } DIV.pmlinks UL.links { PADDING-RIGHT: 0px; LIST-STYLE: none none outside; BORDER-TOP: #cccccc = 1px solid; DISPLAY: block; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; FONT-FAMILY: Arial,Helvetica,sans-serif } DIV.cited-ref UL { PADDING-RIGHT: 0px; LIST-STYLE: none none outside; BORDER-TOP: #cccccc = 1px solid; DISPLAY: block; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; FONT-FAMILY: Arial,Helvetica,sans-serif } DIV.pmlinks UL.links LI.ovfl { DISPLAY: block; FONT-SIZE: 80%; BACKGROUND: = url(/portal/portalrc.fcgi/40595/img/28247) no-repeat left top; MARGIN: = 0.75em 0.2em 0px 0px; OVERFLOW: hidden; WIDTH: 100%; LINE-HEIGHT: 1.2em; = ZOOM: 1; POSITION: relative } DIV.cited-ref LI.ovfl { DISPLAY: block; FONT-SIZE: 80%; BACKGROUND: = url(/portal/portalrc.fcgi/40595/img/28247) no-repeat left top; MARGIN: = 0.75em 0.2em 0px 0px; OVERFLOW: hidden; WIDTH: 100%; LINE-HEIGHT: 1.2em; = ZOOM: 1; POSITION: relative } DIV.pmlinks UL.links LI.ovfl A.pl { DISPLAY: block; PADDING-LEFT: 1.5em; OVERFLOW: hidden; COLOR: = rgb(35,35,35); HEIGHT: 2.4em; TEXT-DECORATION: none } DIV.cited-ref LI.ovfl A.pl { DISPLAY: block; PADDING-LEFT: 1.5em; OVERFLOW: hidden; COLOR: = rgb(35,35,35); HEIGHT: 2.4em; TEXT-DECORATION: none } DIV.pmlinks UL.links LI.ovfl A.pl:hover { TEXT-DECORATION: underline } DIV.cited-ref LI.ovfl A.pl:hover { TEXT-DECORATION: underline } DIV.pmlinks UL.links LI.ovfl SPAN.pub { PADDING-RIGHT: 0.5em; MARGIN-TOP: 0.2em; DISPLAY: block; PADDING-LEFT: = 0.5em; Z-INDEX: 4; RIGHT: 0px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = COLOR: #666; BOTTOM: -0.2em; PADDING-TOP: 0px; ZOOM: 1; FONT-FAMILY: = Verdana,Arial,Sans-Serif; WHITE-SPACE: nowrap; LETTER-SPACING: -1px; = POSITION: absolute; BACKGROUND-COLOR: #f8f8f8 } DIV.cited-ref LI.ovfl SPAN.pub { PADDING-RIGHT: 0.5em; MARGIN-TOP: 0.2em; DISPLAY: block; PADDING-LEFT: = 0.5em; Z-INDEX: 4; RIGHT: 0px; PADDING-BOTTOM: 2px; OVERFLOW: hidden; = COLOR: #666; BOTTOM: -0.2em; PADDING-TOP: 0px; ZOOM: 1; FONT-FAMILY: = Verdana,Arial,Sans-Serif; WHITE-SPACE: nowrap; LETTER-SPACING: -1px; = POSITION: absolute; BACKGROUND-COLOR: #f8f8f8 } DIV.pmlinks UL.links LI.ovfl SPAN.flag { PADDING-RIGHT: 0.3em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; PADDING-BOTTOM: 0px; VERTICAL-ALIGN: middle; COLOR: = white; MARGIN-RIGHT: 0.5em; PADDING-TOP: 0px; FONT-STYLE: italic; = BACKGROUND-COLOR: #a81b0e } DIV.cited-ref LI.ovfl SPAN.flag { PADDING-RIGHT: 0.3em; MARGIN-TOP: -0.1em; PADDING-LEFT: 0.2em; = FONT-WEIGHT: 500; PADDING-BOTTOM: 0px; VERTICAL-ALIGN: middle; COLOR: = white; MARGIN-RIGHT: 0.5em; PADDING-TOP: 0px; FONT-STYLE: italic; = BACKGROUND-COLOR: #a81b0e } P.desc { DISPLAY: none } DIV.brieflink DIV.PPMCPubmedRA UL LI.item P.note { BACKGROUND-COLOR: #f8f8f8 } DIV.cited-ref { LEFT: -1000px; TEXT-ALIGN: right } DIV.cited-ref UL { PADDING-TOP: 0.55em; TEXT-ALIGN: left } DIV.cited-ref A.all-articles { MARGIN-TOP: 0.5em; DISPLAY: block; FONT-SIZE: 80%; COLOR: = rgb(35,35,35); TEXT-DECORATION: none } DIV.cited-ref A.all-articles:hover { TEXT-DECORATION: underline } DIV.port { MIN-WIDTH: 250px; MAX-WIDTH: 350px; MARGIN-LEFT: 0.75em; WIDTH: 350px } DIV.x-panel-body { BACKGROUND-COLOR: transparent } DIV.sameauthor-seemore { FONT-SIZE: 75%; TEXT-ALIGN: right } DIV.x-panel-body SPAN.separator-bar { MARGIN: 0px 0.5em; COLOR: #ccc } SPAN.review { PADDING-RIGHT: 0.1em; PADDING-LEFT: 0.1em; FONT-SIZE: 85%; = PADDING-BOTTOM: 0.1em; COLOR: #fff; PADDING-TOP: 0.1em; FONT-STYLE: = italic; BACKGROUND-COLOR: #a81b0e } @media Print =20 { HTML BODY.pmc-body { MIN-WIDTH: 0px } TD.sidebar-cell DIV.port { DISPLAY: none } #ArticleRefDocsums { DISPLAY: none } .format-menu { DISPLAY: none } .other-sections { DISPLAY: none } TD.content-cell { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } DIV.section-content > DIV.p { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } DIV.sec { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } #Table3 TD.sidebar-cell { MIN-WIDTH: 0px; MAX-WIDTH: none; WIDTH: auto } TD.content-cell { PADDING-LEFT: 0px } .canvas-media-player-outer .splash-ph { DISPLAY: none } } .mb { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .mb UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; LINE-HEIGHT: 1; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .mb A { DISPLAY: block; WIDTH: 10em; CURSOR: pointer; TEXT-DECORATION: = underline; outline: none } .mb LI { FLOAT: left; WIDTH: 10em } .mb A.first-link { COLOR: #336699; TEXT-DECORATION: none } UL.mb LI SPAN.delta { COLOR: #336699 } .mb LI UL.submenu { LEFT: -999em; WIDTH: 10em; POSITION: absolute } .mb LI UL UL { MARGIN: -1em 0px 0px 10em } UL.mb LI.submenu-item UL { BORDER-RIGHT: red 1px solid; BORDER-TOP: red 1px solid; LEFT: -999em; = BORDER-LEFT: red 1px solid; BORDER-BOTTOM: red 1px solid; POSITION: = absolute } UL.mb LI.active-item UL { LEFT: 3px } UL.mb LI UL.opened { BORDER-RIGHT: #ffffff 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #ffffff 1px solid; MARGIN-TOP: 4px; PADDING-LEFT: 2px; LEFT: auto; = PADDING-BOTTOM: 2px; BORDER-LEFT: #ffffff 1px solid; PADDING-TOP: 2px; = BORDER-BOTTOM: #ffffff 1px solid; BACKGROUND-COLOR: #ffffff } UL.mb LI UL.opened LI { MARGIN-BOTTOM: 3px } UL.mb LI UL.opened LI.active-item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: #336699; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } UL.opened LI.active-item A { COLOR: #ffffff } UL.mb LI UL A { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 2px; MARGIN: 0px = 3px; COLOR: #222222; PADDING-TOP: 2px; TEXT-DECORATION: none } TD.content-cell { MIN-WIDTH: 550px; WIDTH: 550px } #Table3 { TABLE-LAYOUT: fixed } .col-watermark { MIN-WIDTH: 20px; WIDTH: 20px } .col-content { MIN-WIDTH: 570px; WIDTH: 570px } .col-sidebar { MIN-WIDTH: 370px; WIDTH: 370px } ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/js/jquery-1.3.2.min.js /*=0A= * jQuery JavaScript Library v1.3.2=0A= * http://jquery.com/=0A= *=0A= * Copyright (c) 2009 John Resig=0A= * Dual licensed under the MIT and GPL licenses.=0A= * http://docs.jquery.com/License=0A= *=0A= * Date: 2009-02-19 17:34:21 -0500 (Thu, 19 Feb 2009)=0A= * Revision: 6246=0A= */=0A= (function(){var = l=3Dthis,g,y=3Dl.jQuery,p=3Dl.$,o=3Dl.jQuery=3Dl.$=3Dfunction(E,F){return= new = o.fn.init(E,F)},D=3D/^[^<]*(<(.|\s)+>)[^>]*$|^#([\w-]+)$/,f=3D/^.[^:#\[\.= ,]*$/;o.fn=3Do.prototype=3D{init:function(E,H){E=3DE||document;if(E.nodeT= ype){this[0]=3DE;this.length=3D1;this.context=3DE;return this}if(typeof = E=3D=3D=3D"string"){var = G=3DD.exec(E);if(G&&(G[1]||!H)){if(G[1]){E=3Do.clean([G[1]],H)}else{var = I=3Ddocument.getElementById(G[3]);if(I&&I.id!=3DG[3]){return = o().find(E)}var F=3Do(I||[]);F.context=3Ddocument;F.selector=3DE;return = F}}else{return o(H).find(E)}}else{if(o.isFunction(E)){return = o(document).ready(E)}}if(E.selector&&E.context){this.selector=3DE.selecto= r;this.context=3DE.context}return = this.setArray(o.isArray(E)?E:o.makeArray(E))},selector:"",jquery:"1.3.2",= size:function(){return this.length},get:function(E){return = E=3D=3D=3Dg?Array.prototype.slice.call(this):this[E]},pushStack:function(= F,H,E){var = G=3Do(F);G.prevObject=3Dthis;G.context=3Dthis.context;if(H=3D=3D=3D"find"= ){G.selector=3Dthis.selector+(this.selector?" = ":"")+E}else{if(H){G.selector=3Dthis.selector+"."+H+"("+E+")"}}return = G},setArray:function(E){this.length=3D0;Array.prototype.push.apply(this,E= );return this},each:function(F,E){return = o.each(this,F,E)},index:function(E){return = o.inArray(E&&E.jquery?E[0]:E,this)},attr:function(F,H,G){var = E=3DF;if(typeof F=3D=3D=3D"string"){if(H=3D=3D=3Dg){return = this[0]&&o[G||"attr"](this[0],F)}else{E=3D{};E[F]=3DH}}return = this.each(function(I){for(F in = E){o.attr(G?this.style:this,F,o.prop(this,E[F],G,I,F))}})},css:function(E= ,F){if((E=3D=3D"width"||E=3D=3D"height")&&parseFloat(F)<0){F=3Dg}return = this.attr(E,F,"curCSS")},text:function(F){if(typeof = F!=3D=3D"object"&&F!=3Dnull){return = this.empty().append((this[0]&&this[0].ownerDocument||document).createText= Node(F))}var = E=3D"";o.each(F||this,function(){o.each(this.childNodes,function(){if(thi= s.nodeType!=3D8){E+=3Dthis.nodeType!=3D1?this.nodeValue:o.fn.text([this])= }})});return E},wrapAll:function(E){if(this[0]){var = F=3Do(E,this[0].ownerDocument).clone();if(this[0].parentNode){F.insertBef= ore(this[0])}F.map(function(){var = G=3Dthis;while(G.firstChild){G=3DG.firstChild}return = G}).append(this)}return this},wrapInner:function(E){return = this.each(function(){o(this).contents().wrapAll(E)})},wrap:function(E){re= turn this.each(function(){o(this).wrapAll(E)})},append:function(){return = this.domManip(arguments,true,function(E){if(this.nodeType=3D=3D1){this.ap= pendChild(E)}})},prepend:function(){return = this.domManip(arguments,true,function(E){if(this.nodeType=3D=3D1){this.in= sertBefore(E,this.firstChild)}})},before:function(){return = this.domManip(arguments,false,function(E){this.parentNode.insertBefore(E,= this)})},after:function(){return = this.domManip(arguments,false,function(E){this.parentNode.insertBefore(E,= this.nextSibling)})},end:function(){return = this.prevObject||o([])},push:[].push,sort:[].sort,splice:[].splice,find:f= unction(E){if(this.length=3D=3D=3D1){var = F=3Dthis.pushStack([],"find",E);F.length=3D0;o.find(E,this[0],F);return = F}else{return this.pushStack(o.unique(o.map(this,function(G){return = o.find(E,G)})),"find",E)}},clone:function(G){var = E=3Dthis.map(function(){if(!o.support.noCloneEvent&&!o.isXMLDoc(this)){va= r I=3Dthis.outerHTML;if(!I){var = J=3Dthis.ownerDocument.createElement("div");J.appendChild(this.cloneNode(= true));I=3DJ.innerHTML}return o.clean([I.replace(/ = jQuery\d+=3D"(?:\d+|null)"/g,"").replace(/^\s*/,"")])[0]}else{return = this.cloneNode(true)}});if(G=3D=3D=3Dtrue){var = H=3Dthis.find("*").andSelf(),F=3D0;E.find("*").andSelf().each(function(){= if(this.nodeName!=3D=3DH[F].nodeName){return}var = I=3Do.data(H[F],"events");for(var K in I){for(var J in = I[K]){o.event.add(this,K,I[K][J],I[K][J].data)}}F++})}return = E},filter:function(E){return = this.pushStack(o.isFunction(E)&&o.grep(this,function(G,F){return = E.call(G,F)})||o.multiFilter(E,o.grep(this,function(F){return = F.nodeType=3D=3D=3D1})),"filter",E)},closest:function(E){var = G=3Do.expr.match.POS.test(E)?o(E):null,F=3D0;return = this.map(function(){var = H=3Dthis;while(H&&H.ownerDocument){if(G?G.index(H)>-1:o(H).is(E)){o.data(= H,"closest",F);return = H}H=3DH.parentNode;F++}})},not:function(E){if(typeof = E=3D=3D=3D"string"){if(f.test(E)){return = this.pushStack(o.multiFilter(E,this,true),"not",E)}else{E=3Do.multiFilter= (E,this)}}var F=3DE.length&&E[E.length-1]!=3D=3Dg&&!E.nodeType;return = this.filter(function(){return = F?o.inArray(this,E)<0:this!=3DE})},add:function(E){return = this.pushStack(o.unique(o.merge(this.get(),typeof = E=3D=3D=3D"string"?o(E):o.makeArray(E))))},is:function(E){return = !!E&&o.multiFilter(E,this).length>0},hasClass:function(E){return = !!E&&this.is("."+E)},val:function(K){if(K=3D=3D=3Dg){var = E=3Dthis[0];if(E){if(o.nodeName(E,"option")){return(E.attributes.value||{= }).specified?E.value:E.text}if(o.nodeName(E,"select")){var = I=3DE.selectedIndex,L=3D[],M=3DE.options,H=3DE.type=3D=3D"select-one";if(= I<0){return null}for(var F=3DH?I:0,J=3DH?I+1:M.length;F=3D0= ||o.inArray(this.name,K)>=3D0)}else{if(o.nodeName(this,"select")){var = N=3Do.makeArray(K);o("option",this).each(function(){this.selected=3D(o.in= Array(this.value,N)>=3D0||o.inArray(this.text,N)>=3D0)});if(!N.length){th= is.selectedIndex=3D-1}}else{this.value=3DK}}})},html:function(E){return = E=3D=3D=3Dg?(this[0]?this[0].innerHTML.replace(/ = jQuery\d+=3D"(?:\d+|null)"/g,""):null):this.empty().append(E)},replaceWit= h:function(E){return this.after(E).remove()},eq:function(E){return = this.slice(E,+E+1)},slice:function(){return = this.pushStack(Array.prototype.slice.apply(this,arguments),"slice",Array.= prototype.slice.call(arguments).join(","))},map:function(E){return = this.pushStack(o.map(this,function(G,F){return = E.call(G,F,G)}))},andSelf:function(){return = this.add(this.prevObject)},domManip:function(J,M,L){if(this[0]){var = I=3D(this[0].ownerDocument||this[0]).createDocumentFragment(),F=3Do.clean= (J,(this[0].ownerDocument||this[0]),I),H=3DI.firstChild;if(H){for(var = G=3D0,E=3Dthis.length;G1||G>0?I.c= loneNode(true):I)}}if(F){o.each(F,z)}}return this;function K(N,O){return = M&&o.nodeName(N,"table")&&o.nodeName(O,"tr")?(N.getElementsByTagName("tbo= dy")[0]||N.appendChild(N.ownerDocument.createElement("tbody"))):N}}};o.fn= .init.prototype=3Do.fn;function = z(E,F){if(F.src){o.ajax({url:F.src,async:false,dataType:"script"})}else{o= .globalEval(F.text||F.textContent||F.innerHTML||"")}if(F.parentNode){F.pa= rentNode.removeChild(F)}}function e(){return +new = Date}o.extend=3Do.fn.extend=3Dfunction(){var = J=3Darguments[0]||{},H=3D1,I=3Darguments.length,E=3Dfalse,G;if(typeof = J=3D=3D=3D"boolean"){E=3DJ;J=3Darguments[1]||{};H=3D2}if(typeof = J!=3D=3D"object"&&!o.isFunction(J)){J=3D{}}if(I=3D=3DH){J=3Dthis;--H}for(= ;H-1}},swap:functi= on(H,G,I){var E=3D{};for(var F in = G){E[F]=3DH.style[F];H.style[F]=3DG[F]}I.call(H);for(var F in = G){H.style[F]=3DE[F]}},css:function(H,F,J,E){if(F=3D=3D"width"||F=3D=3D"h= eight"){var = L,G=3D{position:"absolute",visibility:"hidden",display:"block"},K=3DF=3D=3D= "width"?["Left","Right"]:["Top","Bottom"];function = I(){L=3DF=3D=3D"width"?H.offsetWidth:H.offsetHeight;if(E=3D=3D=3D"border"= ){return}o.each(K,function(){if(!E){L-=3DparseFloat(o.curCSS(H,"padding"+= this,true))||0}if(E=3D=3D=3D"margin"){L+=3DparseFloat(o.curCSS(H,"margin"= +this,true))||0}else{L-=3DparseFloat(o.curCSS(H,"border"+this+"Width",tru= e))||0}})}if(H.offsetWidth!=3D=3D0){I()}else{o.swap(H,G,I)}return = Math.max(0,Math.round(L))}return = o.curCSS(H,F,J)},curCSS:function(I,F,G){var = L,E=3DI.style;if(F=3D=3D"opacity"&&!o.support.opacity){L=3Do.attr(E,"opac= ity");return = L=3D=3D""?"1":L}if(F.match(/float/i)){F=3Dw}if(!G&&E&&E[F]){L=3DE[F]}else= {if(q.getComputedStyle){if(F.match(/float/i)){F=3D"float"}F=3DF.replace(/= ([A-Z])/g,"-$1").toLowerCase();var = M=3Dq.getComputedStyle(I,null);if(M){L=3DM.getPropertyValue(F)}if(F=3D=3D= "opacity"&&L=3D=3D""){L=3D"1"}}else{if(I.currentStyle){var = J=3DF.replace(/\-(\w)/g,function(N,O){return = O.toUpperCase()});L=3DI.currentStyle[F]||I.currentStyle[J];if(!/^\d+(px)?= $/i.test(L)&&/^\d/.test(L)){var = H=3DE.left,K=3DI.runtimeStyle.left;I.runtimeStyle.left=3DI.currentStyle.l= eft;E.left=3DL||0;L=3DE.pixelLeft+"px";E.left=3DH;I.runtimeStyle.left=3DK= }}}}return L},clean:function(F,K,I){K=3DK||document;if(typeof = K.createElement=3D=3D=3D"undefined"){K=3DK.ownerDocument||K[0]&&K[0].owne= rDocument||document}if(!I&&F.length=3D=3D=3D1&&typeof = F[0]=3D=3D=3D"string"){var = H=3D/^<(\w+)\s*\/?>$/.exec(F[0]);if(H){return[K.createElement(H[1])]}}var= = G=3D[],E=3D[],L=3DK.createElement("div");o.each(F,function(P,S){if(typeof= S=3D=3D=3D"number"){S+=3D""}if(!S){return}if(typeof = S=3D=3D=3D"string"){S=3DS.replace(/(<(\w+)[^>]*?)\/>/g,function(U,V,T){re= turn = T.match(/^(abbr|br|col|img|input|link|meta|param|hr|area|embed)$/i)?U:V+"= >"});var = O=3DS.replace(/^\s+/,"").substring(0,10).toLowerCase();var = Q=3D!O.indexOf("",""]||!O.indexOf(""= ,""]||O.match(/^<(thead|tbody|tfoot|colg|cap)/)&&[1,"",= "
"]||!O.indexOf("
"]||= (!O.indexOf("",""]||!O.indexOf("= ",""]||!o.support.htmlSerialize&&[1,"div
","
= "]||[0,"",""];L.innerHTML=3DQ[1]+S+Q[2];while(Q[0]--){L=3DL.lastChild}if(= !o.support.tbody){var = R=3D/"&&!R?L.childNodes:[];for(var = M=3DN.length-1;M>=3D0;--M){if(o.nodeName(N[M],"tbody")&&!N[M].childNodes.= length){N[M].parentNode.removeChild(N[M])}}}if(!o.support.leadingWhitespa= ce&&/^\s/.test(S)){L.insertBefore(K.createTextNode(S.match(/^\s*/)[0]),L.= firstChild)}S=3Do.makeArray(L.childNodes)}if(S.nodeType){G.push(S)}else{G= =3Do.merge(G,S)}});if(I){for(var = J=3D0;G[J];J++){if(o.nodeName(G[J],"script")&&(!G[J].type||G[J].type.toLo= werCase()=3D=3D=3D"text/javascript")){E.push(G[J].parentNode?G[J].parentN= ode.removeChild(G[J]):G[J])}else{if(G[J].nodeType=3D=3D=3D1){G.splice.app= ly(G,[J+1,0].concat(o.makeArray(G[J].getElementsByTagName("script"))))}I.= appendChild(G[J])}}return E}return = G},attr:function(J,G,K){if(!J||J.nodeType=3D=3D3||J.nodeType=3D=3D8){retu= rn g}var = H=3D!o.isXMLDoc(J),L=3DK!=3D=3Dg;G=3DH&&o.props[G]||G;if(J.tagName){var = F=3D/href|src|style/.test(G);if(G=3D=3D"selected"&&J.parentNode){J.parent= Node.selectedIndex}if(G in = J&&H&&!F){if(L){if(G=3D=3D"type"&&o.nodeName(J,"input")&&J.parentNode){th= row"type property can't be = changed"}J[G]=3DK}if(o.nodeName(J,"form")&&J.getAttributeNode(G)){return = J.getAttributeNode(G).nodeValue}if(G=3D=3D"tabIndex"){var = I=3DJ.getAttributeNode("tabIndex");return = I&&I.specified?I.value:J.nodeName.match(/(button|input|object|select|text= area)/i)?0:J.nodeName.match(/^(a|area)$/i)&&J.href?0:g}return = J[G]}if(!o.support.style&&H&&G=3D=3D"style"){return = o.attr(J.style,"cssText",K)}if(L){J.setAttribute(G,""+K)}var = E=3D!o.support.hrefNormalized&&H&&F?J.getAttribute(G,2):J.getAttribute(G)= ;return = E=3D=3D=3Dnull?g:E}if(!o.support.opacity&&G=3D=3D"opacity"){if(L){J.zoom=3D= 1;J.filter=3D(J.filter||"").replace(/alpha\([^)]*\)/,"")+(parseInt(K)+""=3D= =3D"NaN"?"":"alpha(opacity=3D"+K*100+")")}return = J.filter&&J.filter.indexOf("opacity=3D")>=3D0?(parseFloat(J.filter.match(= /opacity=3D([^)]*)/)[1])/100)+"":""}G=3DG.replace(/-([a-z])/ig,function(M= ,N){return N.toUpperCase()});if(L){J[G]=3DK}return = J[G]},trim:function(E){return(E||"").replace(/^\s+|\s+$/g,"")},makeArray:= function(G){var E=3D[];if(G!=3Dnull){var = F=3DG.length;if(F=3D=3Dnull||typeof = G=3D=3D=3D"string"||o.isFunction(G)||G.setInterval){E[0]=3DG}else{while(F= ){E[--F]=3DG[F]}}}return E},inArray:function(G,H){for(var = E=3D0,F=3DH.length;E0?this.clone(true):this).get();o.fn[F].apply(o(L[K]),I);J=3DJ.conc= at(I)}return = this.pushStack(J,E,G)}});o.each({removeAttr:function(E){o.attr(this,E,"")= ;if(this.nodeType=3D=3D1){this.removeAttribute(E)}},addClass:function(E){= o.className.add(this,E)},removeClass:function(E){o.className.remove(this,= E)},toggleClass:function(F,E){if(typeof = E!=3D=3D"boolean"){E=3D!o.className.has(this,F)}o.className[E?"add":"remo= ve"](this,F)},remove:function(E){if(!E||o.filter(E,[this]).length){o("*",= this).add([this]).each(function(){o.event.remove(this);o.removeData(this)= });if(this.parentNode){this.parentNode.removeChild(this)}}},empty:functio= n(){o(this).children().remove();while(this.firstChild){this.removeChild(t= his.firstChild)}}},function(E,F){o.fn[E]=3Dfunction(){return = this.each(F,arguments)}});function j(E,F){return = E[0]&&parseInt(o.curCSS(E[0],F,true),10)||0}var = h=3D"jQuery"+e(),v=3D0,A=3D{};o.extend({cache:{},data:function(F,E,G){F=3D= F=3D=3Dl?A:F;var = H=3DF[h];if(!H){H=3DF[h]=3D++v}if(E&&!o.cache[H]){o.cache[H]=3D{}}if(G!=3D= =3Dg){o.cache[H][E]=3DG}return = E?o.cache[H][E]:H},removeData:function(F,E){F=3DF=3D=3Dl?A:F;var = H=3DF[h];if(E){if(o.cache[H]){delete o.cache[H][E];E=3D"";for(E in = o.cache[H]){break}if(!E){o.removeData(F)}}}else{try{delete = F[h]}catch(G){if(F.removeAttribute){F.removeAttribute(h)}}delete = o.cache[H]}},queue:function(F,E,H){if(F){E=3D(E||"fx")+"queue";var = G=3Do.data(F,E);if(!G||o.isArray(H)){G=3Do.data(F,E,o.makeArray(H))}else{= if(H){G.push(H)}}}return G},dequeue:function(H,G){var = E=3Do.queue(H,G),F=3DE.shift();if(!G||G=3D=3D=3D"fx"){F=3DE[0]}if(F!=3D=3D= g){F.call(H)}}});o.fn.extend({data:function(E,G){var = H=3DE.split(".");H[1]=3DH[1]?"."+H[1]:"";if(G=3D=3D=3Dg){var = F=3Dthis.triggerHandler("getData"+H[1]+"!",[H[0]]);if(F=3D=3D=3Dg&&this.l= ength){F=3Do.data(this[0],E)}return = F=3D=3D=3Dg&&H[1]?this.data(H[0]):F}else{return = this.trigger("setData"+H[1]+"!",[H[0],G]).each(function(){o.data(this,E,G= )})}},removeData:function(E){return = this.each(function(){o.removeData(this,E)})},queue:function(E,F){if(typeo= f E!=3D=3D"string"){F=3DE;E=3D"fx"}if(F=3D=3D=3Dg){return = o.queue(this[0],E)}return this.each(function(){var = G=3Do.queue(this,E,F);if(E=3D=3D"fx"&&G.length=3D=3D1){G[0].call(this)}})= },dequeue:function(E){return this.each(function(){o.dequeue(this,E)})}});=0A= /*=0A= * Sizzle CSS Selector Engine - v0.9.3=0A= * Copyright 2009, The Dojo Foundation=0A= * Released under the MIT, BSD, and GPL Licenses.=0A= * More information: http://sizzlejs.com/=0A= */=0A= (function(){var = R=3D/((?:\((?:\([^()]+\)|[^()]+)+\)|\[(?:\[[^[\]]*\]|['"][^'"]*['"]|[^[\]= '"]+)+\]|\\.|[^ = >+~,(\[\\]+)+|[>+~])(\s*,\s*)?/g,L=3D0,H=3DObject.prototype.toString;var = F=3Dfunction(Y,U,ab,ac){ab=3Dab||[];U=3DU||document;if(U.nodeType!=3D=3D1= &&U.nodeType!=3D=3D9){return[]}if(!Y||typeof Y!=3D=3D"string"){return = ab}var = Z=3D[],W,af,ai,T,ad,V,X=3Dtrue;R.lastIndex=3D0;while((W=3DR.exec(Y))!=3D=3D= null){Z.push(W[1]);if(W[2]){V=3DRegExp.rightContext;break}}if(Z.length>1&= &M.exec(Y)){if(Z.length=3D=3D=3D2&&I.relative[Z[0]]){af=3DJ(Z[0]+Z[1],U)}= else{af=3DI.relative[Z[0]]?[U]:F(Z.shift(),U);while(Z.length){Y=3DZ.shift= ();if(I.relative[Y]){Y+=3DZ.shift()}af=3DJ(Y,af)}}}else{var = ae=3Dac?{expr:Z.pop(),set:E(ac)}:F.find(Z.pop(),Z.length=3D=3D=3D1&&U.par= entNode?U.parentNode:U,Q(U));af=3DF.filter(ae.expr,ae.set);if(Z.length>0)= {ai=3DE(af)}else{X=3Dfalse}while(Z.length){var = ah=3DZ.pop(),ag=3Dah;if(!I.relative[ah]){ah=3D""}else{ag=3DZ.pop()}if(ag=3D= =3Dnull){ag=3DU}I.relative[ah](ai,ag,Q(U))}}if(!ai){ai=3Daf}if(!ai){throw= "Syntax error, unrecognized expression: = "+(ah||Y)}if(H.call(ai)=3D=3D=3D"[object = Array]"){if(!X){ab.push.apply(ab,ai)}else{if(U.nodeType=3D=3D=3D1){for(va= r = aa=3D0;ai[aa]!=3Dnull;aa++){if(ai[aa]&&(ai[aa]=3D=3D=3Dtrue||ai[aa].nodeT= ype=3D=3D=3D1&&K(U,ai[aa]))){ab.push(af[aa])}}}else{for(var = aa=3D0;ai[aa]!=3Dnull;aa++){if(ai[aa]&&ai[aa].nodeType=3D=3D=3D1){ab.push= (af[aa])}}}}}else{E(ai,ab)}if(V){F(V,U,ab,ac);if(G){hasDuplicate=3Dfalse;= ab.sort(G);if(hasDuplicate){for(var = aa=3D1;aa":function(Z,U,aa){var X=3Dtypeof = U=3D=3D=3D"string";if(X&&!/\W/.test(U)){U=3Daa?U:U.toUpperCase();for(var = V=3D0,T=3DZ.length;V1||/^\w/.test(X[3])){X[3]=3DF(X[3],null,null,U)}else{var = W=3DF.filter(X[3],U,V,true^Y);if(!V){T.push.apply(T,W)}return = false}}else{if(I.match.POS.test(X[0])||I.match.CHILD.test(X[0])){return = true}}return X},POS:function(T){T.unshift(true);return = T}},filters:{enabled:function(T){return = T.disabled=3D=3D=3Dfalse&&T.type!=3D=3D"hidden"},disabled:function(T){ret= urn T.disabled=3D=3D=3Dtrue},checked:function(T){return = T.checked=3D=3D=3Dtrue},selected:function(T){T.parentNode.selectedIndex;r= eturn T.selected=3D=3D=3Dtrue},parent:function(T){return = !!T.firstChild},empty:function(T){return = !T.firstChild},has:function(V,U,T){return = !!F(T[3],V).length},header:function(T){return/h\d/i.test(T.nodeName)},tex= t:function(T){return"text"=3D=3D=3DT.type},radio:function(T){return"radio= "=3D=3D=3DT.type},checkbox:function(T){return"checkbox"=3D=3D=3DT.type},f= ile:function(T){return"file"=3D=3D=3DT.type},password:function(T){return"= password"=3D=3D=3DT.type},submit:function(T){return"submit"=3D=3D=3DT.typ= e},image:function(T){return"image"=3D=3D=3DT.type},reset:function(T){retu= rn"reset"=3D=3D=3DT.type},button:function(T){return"button"=3D=3D=3DT.typ= e||T.nodeName.toUpperCase()=3D=3D=3D"BUTTON"},input:function(T){return/in= put|select|textarea|button/i.test(T.nodeName)}},setFilters:{first:functio= n(U,T){return T=3D=3D=3D0},last:function(V,U,T,W){return = U=3D=3D=3DW.length-1},even:function(U,T){return = T%2=3D=3D=3D0},odd:function(U,T){return = T%2=3D=3D=3D1},lt:function(V,U,T){return = UT[3]-0},nth:function(V,U,T){return = T[3]-0=3D=3DU},eq:function(V,U,T){return = T[3]-0=3D=3DU}},filter:{PSEUDO:function(Z,V,W,aa){var = U=3DV[1],X=3DI.filters[U];if(X){return = X(Z,W,V,aa)}else{if(U=3D=3D=3D"contains"){return(Z.textContent||Z.innerTe= xt||"").indexOf(V[3])>=3D0}else{if(U=3D=3D=3D"not"){var Y=3DV[3];for(var = W=3D0,T=3DY.length;W=3D0)}}},ID:function(U,T){return = U.nodeType=3D=3D=3D1&&U.getAttribute("id")=3D=3D=3DT},TAG:function(U,T){r= eturn(T=3D=3D=3D"*"&&U.nodeType=3D=3D=3D1)||U.nodeName=3D=3D=3DT},CLASS:f= unction(U,T){return(" "+(U.className||U.getAttribute("class"))+" = ").indexOf(T)>-1},ATTR:function(Y,W){var = V=3DW[1],T=3DI.attrHandle[V]?I.attrHandle[V](Y):Y[V]!=3Dnull?Y[V]:Y.getAt= tribute(V),Z=3DT+"",X=3DW[2],U=3DW[4];return = T=3D=3Dnull?X=3D=3D=3D"!=3D":X=3D=3D=3D"=3D"?Z=3D=3D=3DU:X=3D=3D=3D"*=3D"= ?Z.indexOf(U)>=3D0:X=3D=3D=3D"~=3D"?(" "+Z+" = ").indexOf(U)>=3D0:!U?Z&&T!=3D=3Dfalse:X=3D=3D=3D"!=3D"?Z!=3DU:X=3D=3D=3D= "^=3D"?Z.indexOf(U)=3D=3D=3D0:X=3D=3D=3D"$=3D"?Z.substr(Z.length-U.length= )=3D=3D=3DU:X=3D=3D=3D"|=3D"?Z=3D=3D=3DU||Z.substr(0,U.length+1)=3D=3D=3D= U+"-":false},POS:function(X,U,V,Y){var = T=3DU[2],W=3DI.setFilters[T];if(W){return W(X,V,U,Y)}}}};var = M=3DI.match.POS;for(var O in = I.match){I.match[O]=3DRegExp(I.match[O].source+/(?![^\[]*\])(?![^\(]*\))/= .source)}var = E=3Dfunction(U,T){U=3DArray.prototype.slice.call(U);if(T){T.push.apply(T,= U);return T}return = U};try{Array.prototype.slice.call(document.documentElement.childNodes)}ca= tch(N){E=3Dfunction(X,W){var U=3DW||[];if(H.call(X)=3D=3D=3D"[object = Array]"){Array.prototype.push.apply(U,X)}else{if(typeof = X.length=3D=3D=3D"number"){for(var = V=3D0,T=3DX.length;V";var = T=3Ddocument.documentElement;T.insertBefore(U,T.firstChild);if(!!document= .getElementById(V)){I.find.ID=3Dfunction(X,Y,Z){if(typeof = Y.getElementById!=3D=3D"undefined"&&!Z){var = W=3DY.getElementById(X[1]);return W?W.id=3D=3D=3DX[1]||typeof = W.getAttributeNode!=3D=3D"undefined"&&W.getAttributeNode("id").nodeValue=3D= =3D=3DX[1]?[W]:g:[]}};I.filter.ID=3Dfunction(Y,W){var X=3Dtypeof = Y.getAttributeNode!=3D=3D"undefined"&&Y.getAttributeNode("id");return = Y.nodeType=3D=3D=3D1&&X&&X.nodeValue=3D=3D=3DW}}T.removeChild(U)})();(fun= ction(){var = T=3Ddocument.createElement("div");T.appendChild(document.createComment(""= ));if(T.getElementsByTagName("*").length>0){I.find.TAG=3Dfunction(U,Y){va= r X=3DY.getElementsByTagName(U[1]);if(U[1]=3D=3D=3D"*"){var = W=3D[];for(var = V=3D0;X[V];V++){if(X[V].nodeType=3D=3D=3D1){W.push(X[V])}}X=3DW}return = X}}T.innerHTML=3D"";if(T.firstChild&&typeof = T.firstChild.getAttribute!=3D=3D"undefined"&&T.firstChild.getAttribute("h= ref")!=3D=3D"#"){I.attrHandle.href=3Dfunction(U){return = U.getAttribute("href",2)}}})();if(document.querySelectorAll){(function(){= var T=3DF,U=3Ddocument.createElement("div");U.innerHTML=3D"

";if(U.querySelectorAll&&U.querySelectorAll(".TEST").l= ength=3D=3D=3D0){return}F=3Dfunction(Y,X,V,W){X=3DX||document;if(!W&&X.no= deType=3D=3D=3D9&&!Q(X)){try{return = E(X.querySelectorAll(Y),V)}catch(Z){}}return = T(Y,X,V,W)};F.find=3DT.find;F.filter=3DT.filter;F.selectors=3DT.selectors= ;F.matches=3DT.matches})()}if(document.getElementsByClassName&&document.d= ocumentElement.getElementsByClassName){(function(){var = T=3Ddocument.createElement("div");T.innerHTML=3D"
";if(T.getElementsByClassName("e").length=3D=3D=3D0)= {return}T.lastChild.className=3D"e";if(T.getElementsByClassName("e").leng= th=3D=3D=3D1){return}I.order.splice(1,0,"CLASS");I.find.CLASS=3Dfunction(= U,V,W){if(typeof V.getElementsByClassName!=3D=3D"undefined"&&!W){return = V.getElementsByClassName(U[1])}}})()}function P(U,Z,Y,ad,aa,ac){var = ab=3DU=3D=3D"previousSibling"&&!ac;for(var = W=3D0,V=3Dad.length;W0){X=3DT;break}}}T=3DT[U]}ad[W]=3DX}}}var = K=3Ddocument.compareDocumentPosition?function(U,T){return = U.compareDocumentPosition(T)&16}:function(U,T){return = U!=3D=3DT&&(U.contains?U.contains(T):true)};var Q=3Dfunction(T){return = T.nodeType=3D=3D=3D9&&T.documentElement.nodeName!=3D=3D"HTML"||!!T.ownerD= ocument&&Q(T.ownerDocument)};var J=3Dfunction(T,aa){var = W=3D[],X=3D"",Y,V=3Daa.nodeType?[aa]:aa;while((Y=3DI.match.PSEUDO.exec(T)= )){X+=3DY[0];T=3DT.replace(I.match.PSEUDO,"")}T=3DI.relative[T]?T+"*":T;f= or(var Z=3D0,U=3DV.length;Z0||T.offsetHeight>0};F.selectors.filters.animated=3Dfunctio= n(T){return o.grep(o.timers,function(U){return = T=3D=3D=3DU.elem}).length};o.multiFilter=3Dfunction(V,T,U){if(U){V=3D":no= t("+V+")"}return F.matches(V,T)};o.dir=3Dfunction(V,U){var = T=3D[],W=3DV[U];while(W&&W!=3Ddocument){if(W.nodeType=3D=3D1){T.push(W)}W= =3DW[U]}return T};o.nth=3Dfunction(X,T,V,W){T=3DT||1;var = U=3D0;for(;X;X=3DX[V]){if(X.nodeType=3D=3D1&&++U=3D=3DT){break}}return = X};o.sibling=3Dfunction(V,U){var = T=3D[];for(;V;V=3DV.nextSibling){if(V.nodeType=3D=3D1&&V!=3DU){T.push(V)}= }return = T};return;l.Sizzle=3DF})();o.event=3D{add:function(I,F,H,K){if(I.nodeType= =3D=3D3||I.nodeType=3D=3D8){return}if(I.setInterval&&I!=3Dl){I=3Dl}if(!H.= guid){H.guid=3Dthis.guid++}if(K!=3D=3Dg){var = G=3DH;H=3Dthis.proxy(G);H.data=3DK}var = E=3Do.data(I,"events")||o.data(I,"events",{}),J=3Do.data(I,"handle")||o.d= ata(I,"handle",function(){return typeof = o!=3D=3D"undefined"&&!o.event.triggered?o.event.handle.apply(arguments.ca= llee.elem,arguments):g});J.elem=3DI;o.each(F.split(/\s+/),function(M,N){v= ar = O=3DN.split(".");N=3DO.shift();H.type=3DO.slice().sort().join(".");var = L=3DE[N];if(o.event.specialAll[N]){o.event.specialAll[N].setup.call(I,K,O= )}if(!L){L=3DE[N]=3D{};if(!o.event.special[N]||o.event.special[N].setup.c= all(I,K,O)=3D=3D=3Dfalse){if(I.addEventListener){I.addEventListener(N,J,f= alse)}else{if(I.attachEvent){I.attachEvent("on"+N,J)}}}}L[H.guid]=3DH;o.e= vent.global[N]=3Dtrue});I=3Dnull},guid:1,global:{},remove:function(K,H,J)= {if(K.nodeType=3D=3D3||K.nodeType=3D=3D8){return}var = G=3Do.data(K,"events"),F,E;if(G){if(H=3D=3D=3Dg||(typeof = H=3D=3D=3D"string"&&H.charAt(0)=3D=3D".")){for(var I in = G){this.remove(K,I+(H||""))}}else{if(H.type){J=3DH.handler;H=3DH.type}o.e= ach(H.split(/\s+/),function(M,O){var Q=3DO.split(".");O=3DQ.shift();var = N=3DRegExp("(^|\\.)"+Q.slice().sort().join(".*\\.")+"(\\.|$)");if(G[O]){i= f(J){delete G[O][J.guid]}else{for(var P in = G[O]){if(N.test(G[O][P].type)){delete = G[O][P]}}}if(o.event.specialAll[O]){o.event.specialAll[O].teardown.call(K= ,Q)}for(F in = G[O]){break}if(!F){if(!o.event.special[O]||o.event.special[O].teardown.ca= ll(K,Q)=3D=3D=3Dfalse){if(K.removeEventListener){K.removeEventListener(O,= o.data(K,"handle"),false)}else{if(K.detachEvent){K.detachEvent("on"+O,o.d= ata(K,"handle"))}}}F=3Dnull;delete G[O]}}})}for(F in G){break}if(!F){var = L=3Do.data(K,"handle");if(L){L.elem=3Dnull}o.removeData(K,"events");o.rem= oveData(K,"handle")}}},trigger:function(I,K,H,E){var = G=3DI.type||I;if(!E){I=3Dtypeof = I=3D=3D=3D"object"?I[h]?I:o.extend(o.Event(G),I):o.Event(G);if(G.indexOf(= "!")>=3D0){I.type=3DG=3DG.slice(0,-1);I.exclusive=3Dtrue}if(!H){I.stopPro= pagation();if(this.global[G]){o.each(o.cache,function(){if(this.events&&t= his.events[G]){o.event.trigger(I,K,this.handle.elem)}})}}if(!H||H.nodeTyp= e=3D=3D3||H.nodeType=3D=3D8){return = g}I.result=3Dg;I.target=3DH;K=3Do.makeArray(K);K.unshift(I)}I.currentTarg= et=3DH;var = J=3Do.data(H,"handle");if(J){J.apply(H,K)}if((!H[G]||(o.nodeName(H,"a")&&= G=3D=3D"click"))&&H["on"+G]&&H["on"+G].apply(H,K)=3D=3D=3Dfalse){I.result= =3Dfalse}if(!E&&H[G]&&!I.isDefaultPrevented()&&!(o.nodeName(H,"a")&&G=3D=3D= "click")){this.triggered=3Dtrue;try{H[G]()}catch(L){}}this.triggered=3Dfa= lse;if(!I.isPropagationStopped()){var = F=3DH.parentNode||H.ownerDocument;if(F){o.event.trigger(I,K,F,true)}}},ha= ndle:function(K){var = J,E;K=3Darguments[0]=3Do.event.fix(K||l.event);K.currentTarget=3Dthis;var= = L=3DK.type.split(".");K.type=3DL.shift();J=3D!L.length&&!K.exclusive;var = I=3DRegExp("(^|\\.)"+L.slice().sort().join(".*\\.")+"(\\.|$)");E=3D(o.dat= a(this,"events")||{})[K.type];for(var G in E){var = H=3DE[G];if(J||I.test(H.type)){K.handler=3DH;K.data=3DH.data;var = F=3DH.apply(this,arguments);if(F!=3D=3Dg){K.result=3DF;if(F=3D=3D=3Dfalse= ){K.preventDefault();K.stopPropagation()}}if(K.isImmediatePropagationStop= ped()){break}}}},props:"altKey attrChange attrName bubbles button = cancelable charCode clientX clientY ctrlKey currentTarget data detail = eventPhase fromElement handler keyCode metaKey newValue originalTarget = pageX pageY prevValue relatedNode relatedTarget screenX screenY shiftKey = srcElement target toElement view wheelDelta which".split(" = "),fix:function(H){if(H[h]){return H}var F=3DH;H=3Do.Event(F);for(var = G=3Dthis.props.length,J;G;){J=3Dthis.props[--G];H[J]=3DF[J]}if(!H.target)= {H.target=3DH.srcElement||document}if(H.target.nodeType=3D=3D3){H.target=3D= H.target.parentNode}if(!H.relatedTarget&&H.fromElement){H.relatedTarget=3D= H.fromElement=3D=3DH.target?H.toElement:H.fromElement}if(H.pageX=3D=3Dnul= l&&H.clientX!=3Dnull){var = I=3Ddocument.documentElement,E=3Ddocument.body;H.pageX=3DH.clientX+(I&&I.= scrollLeft||E&&E.scrollLeft||0)-(I.clientLeft||0);H.pageY=3DH.clientY+(I&= &I.scrollTop||E&&E.scrollTop||0)-(I.clientTop||0)}if(!H.which&&((H.charCo= de||H.charCode=3D=3D=3D0)?H.charCode:H.keyCode)){H.which=3DH.charCode||H.= keyCode}if(!H.metaKey&&H.ctrlKey){H.metaKey=3DH.ctrlKey}if(!H.which&&H.bu= tton){H.which=3D(H.button&1?1:(H.button&2?3:(H.button&4?2:0)))}return = H},proxy:function(F,E){E=3DE||function(){return = F.apply(this,arguments)};E.guid=3DF.guid=3DF.guid||E.guid||this.guid++;re= turn = E},special:{ready:{setup:B,teardown:function(){}}},specialAll:{live:{setu= p:function(E,F){o.event.add(this,F[0],c)},teardown:function(G){if(G.lengt= h){var = E=3D0,F=3DRegExp("(^|\\.)"+G[0]+"(\\.|$)");o.each((o.data(this,"events").= live||{}),function(){if(F.test(this.type)){E++}});if(E<1){o.event.remove(= this,G[0],c)}}}}}};o.Event=3Dfunction(E){if(!this.preventDefault){return = new = o.Event(E)}if(E&&E.type){this.originalEvent=3DE;this.type=3DE.type}else{t= his.type=3DE}this.timeStamp=3De();this[h]=3Dtrue};function k(){return = false}function u(){return = true}o.Event.prototype=3D{preventDefault:function(){this.isDefaultPrevent= ed=3Du;var = E=3Dthis.originalEvent;if(!E){return}if(E.preventDefault){E.preventDefaul= t()}E.returnValue=3Dfalse},stopPropagation:function(){this.isPropagationS= topped=3Du;var = E=3Dthis.originalEvent;if(!E){return}if(E.stopPropagation){E.stopPropagat= ion()}E.cancelBubble=3Dtrue},stopImmediatePropagation:function(){this.isI= mmediatePropagationStopped=3Du;this.stopPropagation()},isDefaultPrevented= :k,isPropagationStopped:k,isImmediatePropagationStopped:k};var = a=3Dfunction(F){var = E=3DF.relatedTarget;while(E&&E!=3Dthis){try{E=3DE.parentNode}catch(G){E=3D= this}}if(E!=3Dthis){F.type=3DF.data;o.event.handle.apply(this,arguments)}= };o.each({mouseover:"mouseenter",mouseout:"mouseleave"},function(F,E){o.e= vent.special[E]=3D{setup:function(){o.event.add(this,F,a,E)},teardown:fun= ction(){o.event.remove(this,F,a)}}});o.fn.extend({bind:function(F,G,E){re= turn = F=3D=3D"unload"?this.one(F,G,E):this.each(function(){o.event.add(this,F,E= ||G,E&&G)})},one:function(G,H,F){var = E=3Do.event.proxy(F||H,function(I){o(this).unbind(I,E);return(F||H).apply= (this,arguments)});return = this.each(function(){o.event.add(this,G,E,F&&H)})},unbind:function(F,E){r= eturn = this.each(function(){o.event.remove(this,F,E)})},trigger:function(E,F){re= turn = this.each(function(){o.event.trigger(E,F,this)})},triggerHandler:function= (E,G){if(this[0]){var = F=3Do.Event(E);F.preventDefault();F.stopPropagation();o.event.trigger(F,G= ,this[0]);return F.result}},toggle:function(G){var = E=3Darguments,F=3D1;while(F
a';var = H=3DK.getElementsByTagName("*"),E=3DK.getElementsByTagName("a")[0];if(!H|= |!H.length||!E){return}o.support=3D{leadingWhitespace:K.firstChild.nodeTy= pe=3D=3D3,tbody:!K.getElementsByTagName("tbody").length,objectAll:!!K.get= ElementsByTagName("object")[0].getElementsByTagName("*").length,htmlSeria= lize:!!K.getElementsByTagName("link").length,style:/red/.test(E.getAttrib= ute("style")),hrefNormalized:E.getAttribute("href")=3D=3D=3D"/a",opacity:= E.style.opacity=3D=3D=3D"0.5",cssFloat:!!E.style.cssFloat,scriptEval:fals= e,noCloneEvent:true,boxModel:null};G.type=3D"text/javascript";try{G.appen= dChild(document.createTextNode("window."+J+"=3D1;"))}catch(I){}F.insertBe= fore(G,F.firstChild);if(l[J]){o.support.scriptEval=3Dtrue;delete = l[J]}F.removeChild(G);if(K.attachEvent&&K.fireEvent){K.attachEvent("oncli= ck",function(){o.support.noCloneEvent=3Dfalse;K.detachEvent("onclick",arg= uments.callee)});K.cloneNode(true).fireEvent("onclick")}o(function(){var = L=3Ddocument.createElement("div");L.style.width=3DL.style.paddingLeft=3D"= 1px";document.body.appendChild(L);o.boxModel=3Do.support.boxModel=3DL.off= setWidth=3D=3D=3D2;document.body.removeChild(L).style.display=3D"none"})}= )();var = w=3Do.support.cssFloat?"cssFloat":"styleFloat";o.props=3D{"for":"htmlFor"= ,"class":"className","float":w,cssFloat:w,styleFloat:w,readonly:"readOnly= ",maxlength:"maxLength",cellspacing:"cellSpacing",rowspan:"rowSpan",tabin= dex:"tabIndex"};o.fn.extend({_load:o.fn.load,load:function(G,J,K){if(type= of G!=3D=3D"string"){return this._load(G)}var I=3DG.indexOf(" = ");if(I>=3D0){var E=3DG.slice(I,G.length);G=3DG.slice(0,I)}var = H=3D"GET";if(J){if(o.isFunction(J)){K=3DJ;J=3Dnull}else{if(typeof = J=3D=3D=3D"object"){J=3Do.param(J);H=3D"POST"}}}var = F=3Dthis;o.ajax({url:G,type:H,dataType:"html",data:J,complete:function(M,= L){if(L=3D=3D"success"||L=3D=3D"notmodified"){F.html(E?o("
").append= (M.responseText.replace(//g,"")).find(E):M.respon= seText)}if(K){F.each(K,[M.responseText,L,M])}}});return = this},serialize:function(){return = o.param(this.serializeArray())},serializeArray:function(){return = this.map(function(){return = this.elements?o.makeArray(this.elements):this}).filter(function(){return = this.name&&!this.disabled&&(this.checked||/select|textarea/i.test(this.no= deName)||/text|hidden|password|search/i.test(this.type))}).map(function(E= ,F){var G=3Do(this).val();return = G=3D=3Dnull?null:o.isArray(G)?o.map(G,function(I,H){return{name:F.name,va= lue:I}}):{name:F.name,value:G}}).get()}});o.each("ajaxStart,ajaxStop,ajax= Complete,ajaxError,ajaxSuccess,ajaxSend".split(","),function(E,F){o.fn[F]= =3Dfunction(G){return this.bind(F,G)}});var = r=3De();o.extend({get:function(E,G,H,F){if(o.isFunction(G)){H=3DG;G=3Dnul= l}return = o.ajax({type:"GET",url:E,data:G,success:H,dataType:F})},getScript:functio= n(E,F){return o.get(E,null,F,"script")},getJSON:function(E,F,G){return = o.get(E,F,G,"json")},post:function(E,G,H,F){if(o.isFunction(G)){H=3DG;G=3D= {}}return = o.ajax({type:"POST",url:E,data:G,success:H,dataType:F})},ajaxSetup:functi= on(E){o.extend(o.ajaxSettings,E)},ajaxSettings:{url:location.href,global:= true,type:"GET",contentType:"application/x-www-form-urlencoded",processDa= ta:true,async:true,xhr:function(){return l.ActiveXObject?new = ActiveXObject("Microsoft.XMLHTTP"):new = XMLHttpRequest()},accepts:{xml:"application/xml, = text/xml",html:"text/html",script:"text/javascript, = application/javascript",json:"application/json, = text/javascript",text:"text/plain",_default:"*/*"}},lastModified:{},ajax:= function(M){M=3Do.extend(true,M,o.extend(true,{},o.ajaxSettings,M));var = W,F=3D/=3D\?(&|$)/g,R,V,G=3DM.type.toUpperCase();if(M.data&&M.processData= &&typeof = M.data!=3D=3D"string"){M.data=3Do.param(M.data)}if(M.dataType=3D=3D"jsonp= "){if(G=3D=3D"GET"){if(!M.url.match(F)){M.url+=3D(M.url.match(/\?/)?"&":"= ?")+(M.jsonp||"callback")+"=3D?"}}else{if(!M.data||!M.data.match(F)){M.da= ta=3D(M.data?M.data+"&":"")+(M.jsonp||"callback")+"=3D?"}}M.dataType=3D"j= son"}if(M.dataType=3D=3D"json"&&(M.data&&M.data.match(F)||M.url.match(F))= ){W=3D"jsonp"+r++;if(M.data){M.data=3D(M.data+"").replace(F,"=3D"+W+"$1")= }M.url=3DM.url.replace(F,"=3D"+W+"$1");M.dataType=3D"script";l[W]=3Dfunct= ion(X){V=3DX;I();L();l[W]=3Dg;try{delete = l[W]}catch(Y){}if(H){H.removeChild(T)}}}if(M.dataType=3D=3D"script"&&M.ca= che=3D=3Dnull){M.cache=3Dfalse}if(M.cache=3D=3D=3Dfalse&&G=3D=3D"GET"){va= r E=3De();var = U=3DM.url.replace(/(\?|&)_=3D.*?(&|$)/,"$1_=3D"+E+"$2");M.url=3DU+((U=3D=3D= M.url)?(M.url.match(/\?/)?"&":"?")+"_=3D"+E:"")}if(M.data&&G=3D=3D"GET"){= M.url+=3D(M.url.match(/\?/)?"&":"?")+M.data;M.data=3Dnull}if(M.global&&!o= .active++){o.event.trigger("ajaxStart")}var = Q=3D/^(\w+:)?\/\/([^\/?#]+)/.exec(M.url);if(M.dataType=3D=3D"script"&&G=3D= =3D"GET"&&Q&&(Q[1]&&Q[1]!=3Dlocation.protocol||Q[2]!=3Dlocation.host)){va= r H=3Ddocument.getElementsByTagName("head")[0];var = T=3Ddocument.createElement("script");T.src=3DM.url;if(M.scriptCharset){T.= charset=3DM.scriptCharset}if(!W){var = O=3Dfalse;T.onload=3DT.onreadystatechange=3Dfunction(){if(!O&&(!this.read= yState||this.readyState=3D=3D"loaded"||this.readyState=3D=3D"complete")){= O=3Dtrue;I();L();T.onload=3DT.onreadystatechange=3Dnull;H.removeChild(T)}= }}H.appendChild(T);return g}var K=3Dfalse;var = J=3DM.xhr();if(M.username){J.open(G,M.url,M.async,M.username,M.password)}= else{J.open(G,M.url,M.async)}try{if(M.data){J.setRequestHeader("Content-T= ype",M.contentType)}if(M.ifModified){J.setRequestHeader("If-Modified-Sinc= e",o.lastModified[M.url]||"Thu, 01 Jan 1970 00:00:00 = GMT")}J.setRequestHeader("X-Requested-With","XMLHttpRequest");J.setReques= tHeader("Accept",M.dataType&&M.accepts[M.dataType]?M.accepts[M.dataType]+= ", = */*":M.accepts._default)}catch(S){}if(M.beforeSend&&M.beforeSend(J,M)=3D=3D= =3Dfalse){if(M.global&&!--o.active){o.event.trigger("ajaxStop")}J.abort()= ;return false}if(M.global){o.event.trigger("ajaxSend",[J,M])}var = N=3Dfunction(X){if(J.readyState=3D=3D0){if(P){clearInterval(P);P=3Dnull;i= f(M.global&&!--o.active){o.event.trigger("ajaxStop")}}}else{if(!K&&J&&(J.= readyState=3D=3D4||X=3D=3D"timeout")){K=3Dtrue;if(P){clearInterval(P);P=3D= null}R=3DX=3D=3D"timeout"?"timeout":!o.httpSuccess(J)?"error":M.ifModifie= d&&o.httpNotModified(J,M.url)?"notmodified":"success";if(R=3D=3D"success"= ){try{V=3Do.httpData(J,M.dataType,M)}catch(Z){R=3D"parsererror"}}if(R=3D=3D= "success"){var = Y;try{Y=3DJ.getResponseHeader("Last-Modified")}catch(Z){}if(M.ifModified&= &Y){o.lastModified[M.url]=3DY}if(!W){I()}}else{o.handleError(M,J,R)}L();i= f(X){J.abort()}if(M.async){J=3Dnull}}}};if(M.async){var = P=3DsetInterval(N,13);if(M.timeout>0){setTimeout(function(){if(J&&!K){N("= timeout")}},M.timeout)}}try{J.send(M.data)}catch(S){o.handleError(M,J,nul= l,S)}if(!M.async){N()}function = I(){if(M.success){M.success(V,R)}if(M.global){o.event.trigger("ajaxSucces= s",[J,M])}}function = L(){if(M.complete){M.complete(J,R)}if(M.global){o.event.trigger("ajaxComp= lete",[J,M])}if(M.global&&!--o.active){o.event.trigger("ajaxStop")}}retur= n = J},handleError:function(F,H,E,G){if(F.error){F.error(H,E,G)}if(F.global){= o.event.trigger("ajaxError",[H,F,G])}},active:0,httpSuccess:function(F){t= ry{return = !F.status&&location.protocol=3D=3D"file:"||(F.status>=3D200&&F.status<300= )||F.status=3D=3D304||F.status=3D=3D1223}catch(E){}return = false},httpNotModified:function(G,E){try{var = H=3DG.getResponseHeader("Last-Modified");return = G.status=3D=3D304||H=3D=3Do.lastModified[E]}catch(F){}return = false},httpData:function(J,H,G){var = F=3DJ.getResponseHeader("content-type"),E=3DH=3D=3D"xml"||!H&&F&&F.indexO= f("xml")>=3D0,I=3DE?J.responseXML:J.responseText;if(E&&I.documentElement.= tagName=3D=3D"parsererror"){throw"parsererror"}if(G&&G.dataFilter){I=3DG.= dataFilter(I,H)}if(typeof = I=3D=3D=3D"string"){if(H=3D=3D"script"){o.globalEval(I)}if(H=3D=3D"json")= {I=3Dl["eval"]("("+I+")")}}return I},param:function(E){var = G=3D[];function = H(I,J){G[G.length]=3DencodeURIComponent(I)+"=3D"+encodeURIComponent(J)}if= (o.isArray(E)||E.jquery){o.each(E,function(){H(this.name,this.value)})}el= se{for(var F in = E){if(o.isArray(E[F])){o.each(E[F],function(){H(F,this)})}else{H(F,o.isFu= nction(E[F])?E[F]():E[F])}}}return = G.join("&").replace(/%20/g,"+")}});var = m=3D{},n,d=3D[["height","marginTop","marginBottom","paddingTop","paddingB= ottom"],["width","marginLeft","marginRight","paddingLeft","paddingRight"]= ,["opacity"]];function t(F,E){var = G=3D{};o.each(d.concat.apply([],d.slice(0,E)),function(){G[this]=3DF});re= turn G}o.fn.extend({show:function(J,L){if(J){return = this.animate(t("show",3),J,L)}else{for(var = H=3D0,F=3Dthis.length;H").appendTo("body");K=3DI.css("display");if(K=3D=3D=3D"none"){K=3D"bloc= k"}I.remove();m[G]=3DK}o.data(this[H],"olddisplay",K)}}for(var = H=3D0,F=3Dthis.length;H=3D0;H--){if(G[H].elem=3D=3Dthis){if(E){G[H](true)}G.spl= ice(H,1)}}});if(!E){this.dequeue()}return = this}});o.each({slideDown:t("show",1),slideUp:t("hide",1),slideToggle:t("= toggle",1),fadeIn:{opacity:"show"},fadeOut:{opacity:"hide"}},function(E,F= ){o.fn[E]=3Dfunction(G,H){return = this.animate(F,G,H)}});o.extend({speed:function(G,H,F){var E=3Dtypeof = G=3D=3D=3D"object"?G:{complete:F||!F&&H||o.isFunction(G)&&G,duration:G,ea= sing:F&&H||H&&!o.isFunction(H)&&H};E.duration=3Do.fx.off?0:typeof = E.duration=3D=3D=3D"number"?E.duration:o.fx.speeds[E.duration]||o.fx.spee= ds._default;E.old=3DE.complete;E.complete=3Dfunction(){if(E.queue!=3D=3Df= alse){o(this).dequeue()}if(o.isFunction(E.old)){E.old.call(this)}};return= E},easing:{linear:function(G,H,E,F){return = E+F*G},swing:function(G,H,E,F){return((-Math.cos(G*Math.PI)/2)+0.5)*F+E}}= ,timers:[],fx:function(F,E,G){this.options=3DE;this.elem=3DF;this.prop=3D= G;if(!E.orig){E.orig=3D{}}}});o.fx.prototype=3D{update:function(){if(this= .options.step){this.options.step.call(this.elem,this.now,this)}(o.fx.step= [this.prop]||o.fx.step._default)(this);if((this.prop=3D=3D"height"||this.= prop=3D=3D"width")&&this.elem.style){this.elem.style.display=3D"block"}},= cur:function(F){if(this.elem[this.prop]!=3Dnull&&(!this.elem.style||this.= elem.style[this.prop]=3D=3Dnull)){return this.elem[this.prop]}var = E=3DparseFloat(o.css(this.elem,this.prop,F));return = E&&E>-10000?E:parseFloat(o.curCSS(this.elem,this.prop))||0},custom:functi= on(I,H,G){this.startTime=3De();this.start=3DI;this.end=3DH;this.unit=3DG|= |this.unit||"px";this.now=3Dthis.start;this.pos=3Dthis.state=3D0;var = E=3Dthis;function F(J){return = E.step(J)}F.elem=3Dthis.elem;if(F()&&o.timers.push(F)&&!n){n=3DsetInterva= l(function(){var K=3Do.timers;for(var = J=3D0;J=3Dthis.options.duration+this.startTime){this.now=3Dthis.= end;this.pos=3Dthis.state=3D1;this.update();this.options.curAnim[this.pro= p]=3Dtrue;var E=3Dtrue;for(var F in = this.options.curAnim){if(this.options.curAnim[F]!=3D=3Dtrue){E=3Dfalse}}i= f(E){if(this.options.display!=3Dnull){this.elem.style.overflow=3Dthis.opt= ions.overflow;this.elem.style.display=3Dthis.options.display;if(o.css(thi= s.elem,"display")=3D=3D"none"){this.elem.style.display=3D"block"}}if(this= .options.hide){o(this.elem).hide()}if(this.options.hide||this.options.sho= w){for(var I in = this.options.curAnim){o.attr(this.elem.style,I,this.options.orig[I])}}thi= s.options.complete.call(this.elem)}return false}else{var = J=3DG-this.startTime;this.state=3DJ/this.options.duration;this.pos=3Do.ea= sing[this.options.easing||(o.easing.swing?"swing":"linear")](this.state,J= ,0,1,this.options.duration);this.now=3Dthis.start+((this.end-this.start)*= this.pos);this.update()}return = true}};o.extend(o.fx,{speeds:{slow:600,fast:200,_default:400},step:{opaci= ty:function(E){o.attr(E.elem.style,"opacity",E.now)},_default:function(E)= {if(E.elem.style&&E.elem.style[E.prop]!=3Dnull){E.elem.style[E.prop]=3DE.= now+E.unit}else{E.elem[E.prop]=3DE.now}}}});if(document.documentElement.g= etBoundingClientRect){o.fn.offset=3Dfunction(){if(!this[0]){return{top:0,= left:0}}if(this[0]=3D=3D=3Dthis[0].ownerDocument.body){return = o.offset.bodyOffset(this[0])}var = G=3Dthis[0].getBoundingClientRect(),J=3Dthis[0].ownerDocument,F=3DJ.body,= E=3DJ.documentElement,L=3DE.clientTop||F.clientTop||0,K=3DE.clientLeft||F= .clientLeft||0,I=3DG.top+(self.pageYOffset||o.boxModel&&E.scrollTop||F.sc= rollTop)-L,H=3DG.left+(self.pageXOffset||o.boxModel&&E.scrollLeft||F.scro= llLeft)-K;return{top:I,left:H}}}else{o.fn.offset=3Dfunction(){if(!this[0]= ){return{top:0,left:0}}if(this[0]=3D=3D=3Dthis[0].ownerDocument.body){ret= urn = o.offset.bodyOffset(this[0])}o.offset.initialized||o.offset.initialize();= var = J=3Dthis[0],G=3DJ.offsetParent,F=3DJ,O=3DJ.ownerDocument,M,H=3DO.document= Element,K=3DO.body,L=3DO.defaultView,E=3DL.getComputedStyle(J,null),N=3DJ= .offsetTop,I=3DJ.offsetLeft;while((J=3DJ.parentNode)&&J!=3D=3DK&&J!=3D=3D= H){M=3DL.getComputedStyle(J,null);N-=3DJ.scrollTop,I-=3DJ.scrollLeft;if(J= =3D=3D=3DG){N+=3DJ.offsetTop,I+=3DJ.offsetLeft;if(o.offset.doesNotAddBord= er&&!(o.offset.doesAddBorderForTableAndCells&&/^t(able|d|h)$/i.test(J.tag= Name))){N+=3DparseInt(M.borderTopWidth,10)||0,I+=3DparseInt(M.borderLeftW= idth,10)||0}F=3DG,G=3DJ.offsetParent}if(o.offset.subtractsBorderForOverfl= owNotVisible&&M.overflow!=3D=3D"visible"){N+=3DparseInt(M.borderTopWidth,= 10)||0,I+=3DparseInt(M.borderLeftWidth,10)||0}E=3DM}if(E.position=3D=3D=3D= "relative"||E.position=3D=3D=3D"static"){N+=3DK.offsetTop,I+=3DK.offsetLe= ft}if(E.position=3D=3D=3D"fixed"){N+=3DMath.max(H.scrollTop,K.scrollTop),= I+=3DMath.max(H.scrollLeft,K.scrollLeft)}return{top:N,left:I}}}o.offset=3D= {initialize:function(){if(this.initialized){return}var = L=3Ddocument.body,F=3Ddocument.createElement("div"),H,G,N,I,M,E,J=3DL.sty= le.marginTop,K=3D'
';M=3D{position:"absolute",to= p:0,left:0,margin:0,border:0,width:"1px",height:"1px",visibility:"hidden"= };for(E in = M){F.style[E]=3DM[E]}F.innerHTML=3DK;L.insertBefore(F,L.firstChild);H=3DF= .firstChild,G=3DH.firstChild,I=3DH.nextSibling.firstChild.firstChild;this= .doesNotAddBorder=3D(G.offsetTop!=3D=3D5);this.doesAddBorderForTableAndCe= lls=3D(I.offsetTop=3D=3D=3D5);H.style.overflow=3D"hidden",H.style.positio= n=3D"relative";this.subtractsBorderForOverflowNotVisible=3D(G.offsetTop=3D= =3D=3D-5);L.style.marginTop=3D"1px";this.doesNotIncludeMarginInBodyOffset= =3D(L.offsetTop=3D=3D=3D0);L.style.marginTop=3DJ;L.removeChild(F);this.in= itialized=3Dtrue},bodyOffset:function(E){o.offset.initialized||o.offset.i= nitialize();var = G=3DE.offsetTop,F=3DE.offsetLeft;if(o.offset.doesNotIncludeMarginInBodyOf= fset){G+=3DparseInt(o.curCSS(E,"marginTop",true),10)||0,F+=3DparseInt(o.c= urCSS(E,"marginLeft",true),10)||0}return{top:G,left:F}}};o.fn.extend({pos= ition:function(){var I=3D0,H=3D0,F;if(this[0]){var = G=3Dthis.offsetParent(),J=3Dthis.offset(),E=3D/^body|html$/i.test(G[0].ta= gName)?{top:0,left:0}:G.offset();J.top-=3Dj(this,"marginTop");J.left-=3Dj= (this,"marginLeft");E.top+=3Dj(G,"borderTopWidth");E.left+=3Dj(G,"borderL= eftWidth");F=3D{top:J.top-E.top,left:J.left-E.left}}return = F},offsetParent:function(){var = E=3Dthis[0].offsetParent||document.body;while(E&&(!/^body|html$/i.test(E.= tagName)&&o.css(E,"position")=3D=3D"static")){E=3DE.offsetParent}return = o(E)}});o.each(["Left","Top"],function(F,E){var = G=3D"scroll"+E;o.fn[G]=3Dfunction(H){if(!this[0]){return null}return = H!=3D=3Dg?this.each(function(){this=3D=3Dl||this=3D=3Ddocument?l.scrollTo= (!F?H:o(l).scrollLeft(),F?H:o(l).scrollTop()):this[G]=3DH}):this[0]=3D=3D= l||this[0]=3D=3Ddocument?self[F?"pageYOffset":"pageXOffset"]||o.boxModel&= &document.documentElement[G]||document.body[G]:this[0][G]}});o.each(["Hei= ght","Width"],function(I,G){var = E=3DI?"Left":"Top",H=3DI?"Right":"Bottom",F=3DG.toLowerCase();o.fn["inner= "+G]=3Dfunction(){return = this[0]?o.css(this[0],F,false,"padding"):null};o.fn["outer"+G]=3Dfunction= (K){return this[0]?o.css(this[0],F,false,K?"margin":"border"):null};var = J=3DG.toLowerCase();o.fn[J]=3Dfunction(K){return = this[0]=3D=3Dl?document.compatMode=3D=3D"CSS1Compat"&&document.documentEl= ement["client"+G]||document.body["client"+G]:this[0]=3D=3Ddocument?Math.m= ax(document.documentElement["client"+G],document.body["scroll"+G],documen= t.documentElement["scroll"+G],document.body["offset"+G],document.document= Element["offset"+G]):K=3D=3D=3Dg?(this.length?o.css(this[0],J):null):this= .css(J,typeof K=3D=3D=3D"string"?K:K+"px")}})})(); ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/js/jquery.hoverIntent.min.js /**=0A= * hoverIntent r5 // 2007.03.27 // jQuery 1.1.2+=0A= * =0A= *=0A= */=0A= /*=0A= * modified on 2009.07.01 by Andrey Kolotev=0A= * to support "onclick" event.=0A= * When this event is taking place, the tooltip will be automatically=0A= * hidden after preset timeout, the way it is if=0A= * the mouse moved out of the hovered object.=0A= */=0A= (function(a){a.fn.hoverIntent=3Dfunction(k,j){var = l=3D{sensitivity:7,interval:100,timeout:0};l=3Da.extend(l,j?{over:k,out:j= }:k);var n,m,h,d;var e=3Dfunction(f){n=3Df.pageX;m=3Df.pageY};var = c=3Dfunction(g,f){f.hoverIntent_t=3DclearTimeout(f.hoverIntent_t);if((Mat= h.abs(h-n)+Math.abs(d-m))=0A= String(allOptions).lastIndexOf(barNames[idx] + '=3Dno'))=0A= yAdj +=3D yAdjDelta=0A= }=0A= =0A= try {=0A= if (window.screen.width && width > 0)=0A= moveToX =3D Math.ceil((window.screen.width - width)) - 15=0A= moveToX =3D (moveToX > 0 ? moveToX : moveToXDefault)=0A= =0A= if (window.screen.height && height > 0)=0A= moveToY =3D Math.ceil((window.screen.height - height)) - yAdj=0A= moveToY =3D (moveToY > 0 ? moveToY : moveToYDefault)=0A= }=0A= catch (e) {}=0A= =0A= var wLeftTopCornerOptions =3D ',left=3D' + moveToX + ',top=3D' + = moveToY + ',screenX=3D' + moveToX + ',screenY=3D' + moveToY=0A= =0A= allOptions =3D allOptions + wLeftTopCornerOptions=0A= =0A= w =3D window.open (link, windowname, allOptions)=0A= w.focus()=0A= =0A= link.target=3Dwindowname=0A= =0A= return false;=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function focuswin(windowname)=0A= {=0A= windowname =3D String(windowname).replace(/-/g, "_")=0A= w =3D = window.open("",windowname,"menubar=3Dyes,scrollbars=3Dyes,toolbar=3Dyes,l= ocation=3Dyes,status=3Dyes,directories=3Dyes,resizable=3Dyes");=0A= w.focus();=0A= =0A= return true;=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function reverseString (inStr)=0A= {=0A= var outStr =3D ''=0A= =0A= for (i =3D0; i <=3D inStr.length; i++)=0A= {=0A= outStr =3D inStr.charAt(i) + outStr=0A= }=0A= =0A= return outStr=0A= }=0A= =0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function reverseAndReplaceString (inStr, findStr, newStr)=0A= {=0A= return reverseString(inStr).replace(findStr, newStr)=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function initUnObscureEmail (className, innerHTML)=0A= {=0A= =0A= try{=0A= if (window.addEventListener)=0A= window.addEventListener('load', function() {unObscureEmail = (className, innerHTML)}, false)=0A= else if (window.attachEvent)=0A= window.attachEvent('onload', function() {unObscureEmail = (className, innerHTML)})=0A= }catch(e){=0A= }=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function unObscureEmail (className, innerHTML)=0A= {=0A= try {=0A= if (typeof(unObscuredEmails) =3D=3D 'undefined')=0A= unObscuredEmails =3D new Array()=0A= =0A= if (! unObscuredEmails[className])=0A= {=0A= =0A= var elmnts =3D document.getElementsByTagName("span")=0A= for (var i =3D 0, len =3D elmnts.length; i < len; i++)=0A= {=0A= if (elmnts.item(i).className.indexOf(className, " ") = !=3D -1)=0A= {=0A= elmnts.item(i).innerHTML =3D innerHTML;=0A= unObscuredEmails[className] =3D true=0A= =0A= }=0A= }=0A= }=0A= }=0A= catch(e){=0A= }=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function pubMedDbLinkSubmit(control) {=0A= try{=0A= if (control.pubmedOption)=0A= control =3D control.pubmedOption=0A= if (control.options)=0A= location.href =3D = control.options[control.options.selectedIndex].value;=0A= }=0A= catch(e){}=0A= return false;=0A= }=0A= =0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= // elements "a", "area" with "ref" attribute report to redirect utility = before dereferencing link=0A= //=0A= function initRedirectClicks(report_url) {=0A= =0A= if (report_url && typeof jQuery !=3D 'undefined')=0A= jQuery(document).click(function(e) {=0A= =0A= //=0A= if (!e) return true;=0A= //=0A= if (e.shiftKey || e.altKey || e.ctrlKey) return true;=0A= //=0A= var target =3D jQuery(e.target).closest("a[ref], area[ref]");=0A= if (!target || target.length =3D=3D 0) return true;=0A= //=0A= var ref =3D target.attr("ref");=0A= var href =3D target.attr("href")=0A= =0A= // special processing of href element for pubmed's authors=0A= if (typeof (href) !=3D 'undefined' && = href.indexOf('sites/entrez') && href.indexOf('%5Bauth%5D'))=0A= {=0A= var newHref =3D replacePubMedUnsupportedChars(href);=0A= if (newHref !=3D href)=0A= target.attr("href", newHref)=0A= }=0A= =0A= // append ref with value of href if 'redirect-to-url' is = missing in ref.=0A= if (typeof (ref) !=3D 'undefined' && = ref.indexOf('redirect-to-url') =3D=3D -1)=0A= {=0A= ref =3D ref + '&redirect-to-url=3D' + = encodeURIComponent(href)=0A= //=0A= jQuery.ajax({=0A= type: "HEAD",=0A= url: report_url + '?' + ref,=0A= timeout: 1000,=0A= async: false=0A= });=0A= }=0A= =0A= return true;=0A= });=0A= };=0A= =0A= // function to replace unsupported charachters in author names to be = searchable in PubMed database.=0A= function replacePubMedUnsupportedChars (str)=0A= {=0A= // replace low 128 chars automatically=0A= str =3D str.replace(/%26%23(x000[0-7][0-9a-f])%3b/ig,=0A= function($0, $1){=0A= return (String.fromCharCode('0' + $1))=0A= }=0A= )=0A= // replace others based on map and if it is not in the map replace = with empty string.=0A= str =3D = str.replace(/%26%23(x[0-9a-f][0-9a-f][0-9a-f][0-9a-f][0-9a-f])%3b/ig,=0A= function($0, $1){=0A= return (pubmedUnsupportedCharMap[$1] ? = pubmedUnsupportedCharMap[$1] : '')=0A= }=0A= )=0A= return str;=0A= }=0A= //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= // Based on script written by Dean Edwards, 2005=0A= // http://dean.edwards.name/=0A= =0A= var pmc_script =3D {=0A= addEvent: function(element, type, handler) {=0A= // assign each event handler a unique ID=0A= if (!handler.$$guid) handler.$$guid =3D this.addEvent_guid++;=0A= // create a hash table of event types for the element=0A= if (!element.events) element.events =3D {};=0A= // create a hash table of event handlers for each element/event pair=0A= var handlers =3D element.events[type];=0A= if (!handlers) {=0A= handlers =3D element.events[type] =3D {};=0A= // store the existing event handler (if there is one)=0A= if (element["on" + type]) {=0A= handlers[0] =3D element["on" + type];=0A= }=0A= }=0A= // store the event handler in the hash table=0A= handlers[handler.$$guid] =3D handler;=0A= // assign a global event handler to do all the work=0A= element["on" + type] =3D handleEvent;=0A= =0A= =0A= function handleEvent(event) {=0A= var returnValue =3D true;=0A= // grab the event object (IE uses a global event object)=0A= event =3D event || fixEvent(window.event);=0A= // get a reference to the hash table of event handlers=0A= var handlers =3D this.events[event.type];=0A= // execute each event handler=0A= for (var i in handlers) {=0A= this.$$handleEvent =3D handlers[i];=0A= if (this.$$handleEvent(event) =3D=3D=3D false) {=0A= returnValue =3D false;=0A= }=0A= }=0A= return returnValue;=0A= };=0A= =0A= function fixEvent(event) {=0A= // add W3C standard event methods=0A= event.preventDefault =3D fixEvent.preventDefault;=0A= event.stopPropagation =3D fixEvent.stopPropagation;=0A= return event;=0A= };=0A= =0A= fixEvent.preventDefault =3D function() {=0A= this.returnValue =3D false;=0A= };=0A= =0A= fixEvent.stopPropagation =3D function() {=0A= this.cancelBubble =3D true;=0A= };=0A= },=0A= =0A= // a counter used to create unique IDs=0A= addEvent_guid: 1,=0A= =0A= removeEvent: function(element, type, handler) {=0A= // delete the event handler from the hash table=0A= if (element.events && element.events[type]) {=0A= delete element.events[type][handler.$$guid];=0A= }=0A= }=0A= }=0A= =0A= =0A= // = *************************************************************************= ***=0A= // implementation of figure's popup using jQuery and = jQuery.fn.hoverIntent lib=0A= // it set appropriate handlers for all "a" elements with "figpopup" = class name.=0A= // = *************************************************************************= ***=0A= if (typeof jQuery !=3D 'undefined' && typeof jQuery.fn.hoverIntent !=3D = 'undefined') {=0A= (function($j) {=0A= // = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D hoverHandlers = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=0A= var hoverHandlers =3D function (opts) {=0A= this.config =3D {}=0A= this.self =3D this;=0A= this.__init(opts)=0A= }=0A= =0A= $j.fn.extend(hoverHandlers.prototype, {=0A= //=0A= __init: function(opts) {=0A= $j.fn.extend(this.config, opts)=0A= },=0A= //=0A= over: function (el) {=0A= var canvas =3D $j('.large-thumb-canvas', el)=0A= var prnt =3D canvas.parent();=0A= var win =3D $j(window)=0A= =0A= //=0A= if (canvas && prnt && win)=0A= {=0A= =0A= // collect necessary coordinates from all = intresting objects=0A= canvas.coords =3D this._x_coords(canvas, = 'canvas')=0A= prnt.coords =3D this._x_coords(prnt, = 'parent')=0A= win.coords =3D this._x_coords(win, = 'window')=0A= =0A= // replace @src with value of @hires, because = href hold high resolution image and src low one.=0A= $j('img', canvas).attr('src',=0A= function(){=0A= var hires =3D $j(this).attr("hires");=0A= return (typeof (hires) !=3D = 'undefined' && hires !=3D this.src)=0A= ? hires : this.src=0A= }=0A= )=0A= =0A= // make arrangement of canvas in the view port = nearby parent element.=0A= var cnvsRltvToPrnt =3D = this._x_arrange_canvas(canvas.coords, prnt.coords, win.coords)=0A= =0A= // visualize the canvas with images.=0A= canvas.css('top', cnvsRltvToPrnt.top + 'px')=0A= canvas.css('left', cnvsRltvToPrnt.left + 'px')=0A= canvas.css('display', 'block')=0A= } // canvas=0A= }, // over=0A= //=0A= out: function (el) {=0A= var canvas =3D $j('.large-thumb-canvas', el)=0A= canvas.css('display', 'none')=0A= },=0A= //=0A= _x_offset: function(el, elname) {=0A= var c =3D {}=0A= if (el[0] =3D=3D window )=0A= c =3D this._x_scroll(el, elname)=0A= else=0A= c =3D el.offset()=0A= //console.info('%s.offset {top,left} =3D {%s, %s}', = elname, c.top, c.left)=0A= return c=0A= },=0A= _x_scroll: function(el, elname) {=0A= var c =3D {top: el.scrollTop(), left: = el.scrollLeft()}=0A= //console.info('%s.scroll {top,left} =3D {%s, %s}', = elname, c.top, c.left)=0A= return c=0A= },=0A= _x_width: function(el, elname) {=0A= var w =3D el.outerWidth() || el.width()=0A= //console.info('%s.width =3D %s; outerWidth =3D = %s; width =3D %s', elname, w, el.outerWidth(), el.width())=0A= //IE: alert(elname + '.width =3D ' + w + '; = outerWidth =3D ' + el.outerWidth() + 'width =3D ' + el.width())=0A= return w=0A= },=0A= _x_height: function(el, elname) {=0A= var h =3D el.outerHeight() || el.height()=0A= // console.info('%s.height =3D %s', elname, h)=0A= return h=0A= },=0A= _x_coords: function(el, elname) {=0A= var size =3D { width: this._x_width (el, elname), = height: this._x_height(el, elname)}=0A= var coords =3D {=0A= scroll: this._x_scroll(el, elname),=0A= width: size.width,=0A= height: size.height,=0A= offset: this._x_offset(el, elname),=0A= size: size=0A= }=0A= return coords=0A= },=0A= _x_get_rltv_coord: function(trgtObj, baseObj, = label) {=0A= var c =3D {top: trgtObj.top - baseObj.top, left: = trgtObj.left - baseObj.left}=0A= //console.info("%s {top: %s, left: %s}", label, = c.top, c.left)=0A= return c=0A= },=0A= //=0A= _x_get_empty_space: function(objCoords, = objSize, viewPortCoords, viewPortSize, label) {=0A= var objRelToViewPort =3D = this._x_get_rltv_coord(objCoords, viewPortCoords, '_x_get_empty_space: = for ' + label);=0A= var c =3D {above: objRelToViewPort.top,=0A= below: viewPortSize.height - = (objRelToViewPort.top + objSize.height),=0A= left: objRelToViewPort.left,=0A= right: viewPortSize.width - = (objRelToViewPort.left + objSize.width)}=0A= $j.each(c, function(k, v){c[k] =3D (v < 0 ? 0 : v)})=0A= //console.info("%s {above: %s, below: %s, left: %s, = right: %s}", label, c.above, c.below, c.left, c.right)=0A= return c=0A= },=0A= //=0A= _x_get_bigest_space_area_name: function(spaces, label) {=0A= var sArr =3D [];=0A= for (k in spaces){ sArr[sArr.length] =3D {k: k, v: = spaces[k]} }=0A= // sort in reverse order=0A= sArr.sort (function(a,b){return ( a.v < b.v ? 1 : ( = a.v > b.v ? - 1 : 0 ) )})=0A= // console.info('%s: %s', label, sArr[0].k)=0A= return sArr[0].k=0A= },=0A= //=0A= _x_get_space_ratios: function(spaces, = viewPortSize, label) {=0A= var ratios =3D {above: 0, left: 0}=0A= if (viewPortSize.height > 0)=0A= ratios.above =3D spaces.above / = viewPortSize.height=0A= if (viewPortSize.width > 0)=0A= ratios.left =3D spaces.left / viewPortSize.width=0A= // console.info('ratio: %s {above: %s, left: %s}', = label, ratios.above, ratios.left)=0A= return ratios=0A= },=0A= _x_arrange_canvas: function(c_c, prnt_c, = viewp_c) {=0A= // then calculate empty space areas around parent = element of the canvas, which is ususally an anchor ("a" element)=0A= var emptySpacesArndPrntInViewPort =3D = this._x_get_empty_space (prnt_c.offset, prnt_c.size, viewp_c.offset, = viewp_c.size, 'emptySpacesArndPrntInWinPort')=0A= =0A= // get the area name, where the most linear space = avaiable=0A= var areaName =3D = this._x_get_bigest_space_area_name(emptySpacesArndPrntInViewPort, = viewp_c.size, 'spacios areaName')=0A= =0A= // calculate the proportions of area to be taken by = canvas in empty space area=0A= // relativly to the parent element.=0A= var ratios =3D = this._x_get_space_ratios(emptySpacesArndPrntInViewPort, viewp_c.size, = 'ratios')=0A= =0A= // calculate parent's coordinates relative to view = port=0A= var prntRltvToViewPort =3D = this._x_get_rltv_coord(prnt_c.offset, viewp_c.offset, = 'prntRltvToViewPort')=0A= =0A= // declare canvas relative coordinates=0A= var cnvsRltvToPrnt =3D {top: 0, left: 0}=0A= =0A= // choose appropriate location for placing canvas.=0A= // and choose the 1st element of an array as the one = with the biggest area around parent of canvas.=0A= // console.info ('place it at the %s', = bigestEmptySpaceAreaName)=0A= // calculations are relative to the left corner of = the parent element of canvas. (it has to have the css property = position:relative)=0A= switch (areaName)=0A= {=0A= case 'above':=0A= cnvsRltvToPrnt.top =3D - c_c.height=0A= cnvsRltvToPrnt.left =3D prnt_c.width * 0.5 - = c_c.width * ratios.left=0A= break;=0A= case 'below':=0A= cnvsRltvToPrnt.top =3D prnt_c.height=0A= cnvsRltvToPrnt.left =3D prnt_c.width * 0.5 - = c_c.width * ratios.left=0A= break;=0A= case 'left':=0A= cnvsRltvToPrnt.left =3D - c_c.width=0A= cnvsRltvToPrnt.top =3D prnt_c.height * 0.5 = - c_c.height * ratios.above=0A= break;=0A= case 'right':=0A= cnvsRltvToPrnt.left =3D prnt_c.width=0A= cnvsRltvToPrnt.top =3D prnt_c.height * 0.5 = - c_c.height * ratios.above=0A= break;=0A= }=0A= =0A= // recalculate canvas' coordinates relative to = parent into coordinates relative to view port.=0A= var cnvsRltvToViewPort =3D {=0A= top: prntRltvToViewPort.top + = cnvsRltvToPrnt.top,=0A= left: prntRltvToViewPort.left + = cnvsRltvToPrnt.left=0A= }=0A= //console.info("cnvsRltvToPrnt {top:%s, left: %s}", = cnvsRltvToPrnt.top, cnvsRltvToPrnt.left)=0A= //console.info("cnvsRltvToViewPort {top:%s, left: = %s}", cnvsRltvToViewPort.top, cnvsRltvToViewPort.left)=0A= =0A= // adjust relative position of canvas to the window = if calculated values=0A= // are forcing canvas go out of view port=0A= // next order should be preserved to keep left top = corner visible always=0A= =0A= // adjust right side and move a bit to the left=0A= if (cnvsRltvToViewPort.left + c_c.width > = viewp_c.width)=0A= {=0A= var horAdj =3D c_c.width - (viewp_c.width - = cnvsRltvToViewPort.left)=0A= cnvsRltvToPrnt.left -=3D horAdj=0A= cnvsRltvToViewPort.left -=3D horAdj=0A= //console.log('adjust right side and move to = the left %spx', horizontalAdjustment)=0A= }=0A= =0A= // adjust below side and move to the top=0A= if (cnvsRltvToViewPort.top + c_c.height > = viewp_c.height)=0A= {=0A= var vertAdj =3D c_c.height - (viewp_c.height - = cnvsRltvToViewPort.top)=0A= cnvsRltvToPrnt.top -=3D vertAdj=0A= cnvsRltvToViewPort.top -=3D vertAdj=0A= // console.log('adjust below side and move to = the top %spx', verticalAdjustment)=0A= }=0A= =0A= // adjust left side and move to the right=0A= if (cnvsRltvToViewPort.left < 0)=0A= {=0A= // console.log('adjust left side and move to the = right %spx', -(cnvsLeftRelativeToWindowPort))=0A= cnvsRltvToPrnt.left -=3D = cnvsRltvToViewPort.left=0A= cnvsRltvToViewPort.left =3D 0=0A= }=0A= // adjust above side and move to the bottom=0A= if (cnvsRltvToViewPort.top < 0)=0A= {=0A= // console.log('adjust above side and move to = the bottom %spx', -(cnvsTopRelativeToWindowPort))=0A= cnvsRltvToPrnt.top -=3D = cnvsRltvToViewPort.top=0A= cnvsRltvToViewPort.top =3D 0=0A= }=0A= // console.info("cnvsRltvToPrnt adjusted {top: %s, = left: %s}", cnvsRltvToPrnt.top, cnvsRltvToPrnt.left)=0A= // console.info("cnvsRltvToViewPort adjusted {top: = %s, left: %s}", cnvsRltvToViewPort.top, cnvsRltvToViewPort.left)=0A= return cnvsRltvToPrnt=0A= }=0A= })=0A= // = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D end of hoverHandlers = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= =0A= // = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D $j.fn.figPopup = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=0A= function hoverOverHandler () {=0A= var h =3D new hoverHandlers();=0A= h.over(this)=0A= }=0A= =0A= function hoverOutHandler () {=0A= var h =3D new hoverHandlers();=0A= h.out(this)=0A= }=0A= =0A= $j.fn.figPopup =3D function(opts){=0A= var config =3D {=0A= interval: 500,=0A= timeout: 0,=0A= over: hoverOverHandler, // handler onMouseOver=0A= out: hoverOutHandler // handler onMouseOut=0A= }=0A= $j.extend(config, opts)=0A= return config=0A= }=0A= =0A= // = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D end of $j.fn.figPopup = =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= }) (jQuery) // end of extention of jQuery with figPopup=0A= =0A= =0A= =0A= jQuery(document).ready( function () {=0A= var fp_cfg =3D new jQuery.fn.figPopup()=0A= jQuery('a.figpopup').hoverIntent(fp_cfg)=0A= });=0A= }=0A= =0A= // end of hoverIntent routines for figures' popups=0A= // = *************************************************************************= ***=0A= // implementation of ....=0A= // = *************************************************************************= ***=0A= ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/corehtml/pmc/js/noext.menu.js if (typeof(noext) =3D=3D=3D 'undefined') { noext =3D {};=20 } if (typeof jQuery =3D=3D=3D 'undefined') { throw new Error('noext.Menu: jQuery must be present'); } // Constructor noext.Menu =3D function (n, subMenuStyle) { this.n =3D n; this.subMenuStyle =3D (subMenuStyle =3D=3D=3D 'ext') ? 'opened-ext' = : 'opened'; this.firstLi =3D this.n.children('li'); this.subMenu =3D this.firstLi.find('ul'); this.subMenuItems =3D this.subMenu.find('li'); this.init(); noext.Menu.menuInstances.push(this); }; noext.Menu.menuInstances =3D []; noext.Menu.prototype =3D { init: function () { // add events to what we need var that =3D this; this.subMenuItems.mouseover( this.hover); // do mouseovers for = ie6 this.subMenuItems.mouseout( this.unHover); this.n.click( function (event) { that.update(event);}); // = update the menu =20 jQuery(document).click( function (event) { = that.closeAllSubMenus(event); }); // close other menus when we click one }, update: function (e) { var t =3D jQuery(e.target); =20 // don't follow link if first item, whose target is '' if (t.hasClass('first-link') ) { e.preventDefault(); } var sm =3D this.subMenu; // close other menus this.closeOtherSubMenus(sm); =20 var subMenuStyle =3D this.subMenuStyle; =20 if ( !sm.hasClass(subMenuStyle)) { sm.addClass(subMenuStyle); } else { sm.removeClass(subMenuStyle); } e.stopPropagation(); // don't let default event occur = (removeMenus from document.click) =20 }, hover: function () { jQuery(this).addClass('active-item'); }, unHover: function () { jQuery(this).removeClass('active-item'); }, closeOtherSubMenus: function (currentSubMenu) { // close all menu's submenus, that are different than currently = clicked menu's submenu var subMenuStyle =3D this.subMenuStyle; currentSubMenu =3D this.subMenu; var menuInstances =3D noext.Menu.menuInstances; for (var i =3D 0; i < menuInstances.length; i++) { var menuInstance =3D menuInstances[i]; =20 if (currentSubMenu !=3D=3D menuInstance.subMenu && = menuInstance.subMenu.hasClass(subMenuStyle)) { menuInstance.subMenu.removeClass(subMenuStyle); }=20 } }, closeAllSubMenus: function (event) { // for when user clicks on document var menuInstances =3D noext.Menu.menuInstances; for (var i =3D 0; i < menuInstances.length; i++) { var subMenu =3D this.subMenu; subMenu.removeClass(this.subMenuStyle); } } }; // end of menu objecta jQuery(document).ready( function () { jQuery('ul.noext-menu').removeClass('noext-menu-hidden').each( = function () { noext.Menu.menuInstances.push( new noext.Menu( jQuery(this) ) ); }); }); ------=_NextPart_000_0000_01CAD35F.003A3910 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.ncbi.nlm.nih.gov/portal/js/portal.js =0A= (function(){var = names=3D["log","debug","info","warn","error","assert","dir","dirxml","gro= up","groupEnd","time","timeEnd","count","trace","profile","profileEnd"];t= ry{window.console=3D{};}=0A= catch(e){}=0A= for(var = i=3D0;i+~]/;var = $$STREAM=3D/[\s#.:>+~()@]|[^\s#.:>+~()@]+/g;function = _toStream($selector){if($STANDARD_SELECT.test($selector))$selector=3D" = "+$selector;return $selector.match($$STREAM)||[];};var = $WHITESPACE=3D/\s*([\s>+~(),]|^|$)\s*/g;var = $IMPLIED_ALL=3D/([\s>+~,]|[^(]\+|^)([#.:@])/g;var = parseSelector=3Dfunction($selector){return = $selector.replace($WHITESPACE,"$1").replace($IMPLIED_ALL,"$1*$2");};var = Quote=3D{toString:function(){return"'"},match:/^('[^']*')|("[^"]*")$/,tes= t:function($string){return = this.match.test($string);},add:function($string){return = this.test($string)?$string:this+$string+this;},remove:function($string){r= eturn this.test($string)?$string.slice(1,-1):$string;}};var = getText=3Dfunction($text){return Quote.remove($text);};var = $ESCAPE=3D/([\/()[\]?{}|*+-])/g;function regEscape($string){return = $string.replace($ESCAPE,"\\$1");};loaded=3Dtrue;return = cssQuery;}();function = RemoteDataProvider(sUrl){this.sUrl=3DsUrl;this.bAsync=3Dtrue;this.iTimeou= t=3D0;}=0A= RemoteDataProvider.prototype.x_GetHttpObj=3Dfunction(){var = oHttpObj=3Dnull;try{oHttpObj=3Dnew = ActiveXObject("Msxml2.XMLHTTP");}catch(e){try{oHttpObj=3Dnew = ActiveXObject("Microsoft.XMLHTTP");}catch(oc){oHttpObj=3Dnull;}}=0A= if(!oHttpObj&&typeof XMLHttpRequest!=3D"undefined"){oHttpObj=3Dnew = XMLHttpRequest();}=0A= return = oHttpObj;};RemoteDataProvider.prototype.x_onChange=3Dfunction(oHttpObj,oT= imer){if(oTimer.bTimeout){return;}=0A= if(oHttpObj.readyState=3D=3D4&&oHttpObj.status=3D=3D200){if(oTimer.oTimer= ){clearTimeout(oTimer.oTimer);}=0A= this.onSuccess(oHttpObj);this.onStop();}else = if(oHttpObj.readyState=3D=3D4&&oHttpObj.status!=3D200){if(oTimer.oTimer){= clearTimeout(oTimer.oTimer);}=0A= this.onError(oHttpObj);this.onStop();}};RemoteDataProvider.prototype.x_In= it=3Dfunction(oTimer){var = oHttpObj=3Dthis.x_GetHttpObj();if(null=3D=3DoHttpObj){return null;}=0A= if(oHttpObj.readyState!=3D=3D0){oHttpObj.abort();}=0A= var = oThis=3Dthis;if(this.bAsync){oHttpObj.onreadystatechange=3Dfunction(){oTh= is.x_onChange(oHttpObj,oTimer);};}=0A= this.iActiveRequests++;this.onStart();if(this.iTimeout>0){oTimer.bTimeout= =3Dfalse;oTimer.oTimer=3DsetTimeout(function(){oTimer.bTimeout=3Dtrue;oHt= tpObj.abort();oThis.onTimeout(oThis.iTimeout);},this.iTimeout);}=0A= return = oHttpObj;};RemoteDataProvider.prototype.Get=3Dfunction(sRequest){var = sUrl=3Dthis.sUrl+(sRequest?sRequest:"");var oTimer=3D{};var = oHttpObj=3Dthis.x_Init(oTimer);if(oHttpObj){oHttpObj.open("get",sUrl,this= .bAsync);oHttpObj.send(null);if(!this.bAsync){this.x_onChange(oHttpObj,oT= imer);}}};RemoteDataProvider.prototype.Post=3Dfunction(sRequest){this.Req= uest(null,sRequest);};RemoteDataProvider.prototype.Request=3Dfunction(sGe= tRequest,sPostRequest){var = sUrl=3Dthis.sUrl+(sGetRequest?sGetRequest:"");var oTimer=3D{};var = oHttpObj=3Dthis.x_Init(oTimer);if(oHttpObj){if(typeof = sPostRequest!=3D"string"||sPostRequest=3D=3D=3D""){sPostRequest=3D"";}=0A= oHttpObj.open("post",sUrl,this.bAsync);oHttpObj.setRequestHeader("Content= -type","application/x-www-form-urlencoded");oHttpObj.setRequestHeader("Co= ntent-length",sPostRequest.length);oHttpObj.send(sPostRequest);if(!this.b= Async){this.x_onChange(oHttpObj,oTimer);}}};RemoteDataProvider.prototype.= onSuccess=3Dfunction(obj){alert(["succes:",obj.responseText]);};RemoteDat= aProvider.prototype.onStart=3Dfunction(){};RemoteDataProvider.prototype.o= nStop=3Dfunction(){};RemoteDataProvider.prototype.onError=3Dfunction(obj)= {alert(["error:",obj.status]);};RemoteDataProvider.prototype.onTimeout=3D= function(iTime){alert(["timeout:",iTime+" = ms"]);};xmlHttpCall=3Dfunction(siteName,portletPath,actionName,args,callb= ack,userArgs,oThis){var = xhrArgs=3D{'p$site':siteName,'p$rq':portletPath+":"+actionName};for(var = arg in args){xhrArgs[arg]=3Dargs[arg];}=0A= var query_string=3D"";var hasValue=3Dfalse;for(var arg in xhrArgs){var = sep=3D(hasValue)?"&":"";query_string+=3Dsep+encodeURIComponent(arg);if(xh= rArgs[arg]!=3Dnull){query_string+=3D"=3D"+encodeURIComponent(xhrArgs[arg]= );}=0A= hasValue=3Dtrue;}=0A= var rdp=3Dnew = RemoteDataProvider(window.location.href.replace(/\?.*/,''));rdp.bAsync=3D= (callback!=3Dnull);if(rdp.bAsync){xmlHttpCall._addCall(rdp);}=0A= rdp.iTimeout=3D10000;rdp.onSuccess=3Drdp.onError=3Dfunction(obj){xmlHttpC= all._removeCall(rdp);if(callback&&typeof(callback)=3D=3D'function'){if(oT= his!=3Dnull){callback.call(oThis,obj,userArgs);}else{callback(obj,userArg= s);}}else{throw"xmlHttpCall: callback not defined or not a = function";}};rdp.onTimeout=3Dfunction(obj){xmlHttpCall._removeCall(rdp);v= ar = fakeHttpResponse=3D{'iTimeout':obj,'responseText':null,'responseXML':null= ,'status':408,'statusText':'Request = Timeout'};if(oThis!=3Dnull){if(callback&&typeof(callback)=3D=3D'function'= ){if(oThis!=3Dnull){callback.call(oThis,fakeHttpResponse,userArgs);}else{= callback(fakeHttpResponse,userArgs);}}else{throw"xmlHttpCall: callback = not defined or not a function = (timeout)";}}};rdp.Post(query_string);};xmlHttpCall._activeCalls=3D[];xml= HttpCall._addCall=3Dfunction(xhrObj){xmlHttpCall._activeCalls.push(xhrObj= );};xmlHttpCall._removeCall=3Dfunction(xhrObj){for(var = i=3D0;itest2){dim.w=3DparseInt(x.scrol= lWidth);dim.h=3Dtest1;}else{dim.w=3DparseInt(x.offsetWidth);dim.h=3Dtest2= ;}=0A= return dim;},getWindowDim:function(){var = dim=3D{w:0,h:0};if(self.innerHeight){dim.w=3Dself.innerWidth;dim.h=3Dself= .innerHeight;}else = if(document.documentElement&&document.documentElement.clientHeight){dim.w= =3Ddocument.documentElement.clientWidth;dim.h=3Ddocument.documentElement.= clientHeight;}else = if(document.body){dim.w=3Ddocument.body.clientWidth;dim.h=3Ddocument.body= .clientHeight;}=0A= dim.w=3DparseInt(dim.w);dim.h=3DparseInt(dim.h);return = dim;},getXY:function(oEl,oParent){var = dim=3D{x:0,y:0,w:oEl.offsetWidth,h:oEl.offsetHeight};if(oEl.offsetParent)= {while(oEl&&oEl!=3DoParent){dim.x+=3DoEl.offsetLeft;dim.y+=3DoEl.offsetTo= p;oEl=3DoEl.offsetParent;}}else if(oEl.x){dim.x=3DoEl.x;dim.y=3DoEl.y;}=0A= return dim;},getBorders:function(oEl){var = res=3D{t:0,b:0,l:0,r:0,isInner:false};res.t=3Dthis.getStyle(oEl,"borderTo= pWidth");if(typeof(res.t)=3D=3D"string"&&res.t!=3D""){res.b=3Dthis.getSty= le(oEl,"borderBottomWidth");res.l=3Dthis.getStyle(oEl,"borderLeftWidth");= res.r=3Dthis.getStyle(oEl,"borderRightWidth");}else{res.t=3Dthis.getStyle= (oEl,"border-top-width");res.b=3Dthis.getStyle(oEl,"border-bottom-width")= ;res.l=3Dthis.getStyle(oEl,"border-left-width");res.r=3Dthis.getStyle(oEl= ,"border-right-width");}=0A= if(oEl.currentStyle){res.isInner=3Dtrue;}=0A= res.b=3DparseInt(res.b);if(isNaN(res.b))res.b=3D0;res.t=3DparseInt(res.t)= ;if(isNaN(res.t))res.t=3D0;res.l=3DparseInt(res.l);if(isNaN(res.l))res.l=3D= 0;res.r=3DparseInt(res.r);if(isNaN(res.r))res.r=3D0;return = res;},getPaddings:function(oEl){var = res=3D{t:0,b:0,l:0,r:0};res.t=3Dthis.getStyle(oEl,"paddingTop");if(typeof= (res.t)=3D=3D"string"&&res.t!=3D""){res.b=3Dthis.getStyle(oEl,"paddingBot= tom");res.l=3Dthis.getStyle(oEl,"paddingLeft");res.r=3Dthis.getStyle(oEl,= "paddingRight");}else{res.t=3Dthis.getStyle(oEl,"padding-top");res.b=3Dth= is.getStyle(oEl,"padding-bottom");res.l=3Dthis.getStyle(oEl,"padding-left= ");res.r=3Dthis.getStyle(oEl,"padding-right");}=0A= res.b=3DparseInt(res.b);if(isNaN(res.b))res.b=3D0;res.t=3DparseInt(res.t)= ;if(isNaN(res.t))res.t=3D0;res.l=3DparseInt(res.l);if(isNaN(res.l))res.l=3D= 0;res.r=3DparseInt(res.r);if(isNaN(res.r))res.r=3D0;return = res;},getMargins:function(oEl){var = res=3D{t:0,b:0,l:0,r:0};res.t=3Dthis.getStyle(oEl,"marginTop");if(typeof(= res.t)=3D=3D"string"&&res.t!=3D""){res.b=3Dthis.getStyle(oEl,"marginBotto= m");res.l=3Dthis.getStyle(oEl,"marginLeft");res.r=3Dthis.getStyle(oEl,"ma= rginRight");}else{res.t=3Dthis.getStyle(oEl,"margin-top");res.b=3Dthis.ge= tStyle(oEl,"margin-bottom");res.l=3Dthis.getStyle(oEl,"margin-left");res.= r=3Dthis.getStyle(oEl,"margin-right");}=0A= res.b=3DparseInt(res.b);if(isNaN(res.b))res.b=3D0;res.t=3DparseInt(res.t)= ;if(isNaN(res.t))res.t=3D0;res.l=3DparseInt(res.l);if(isNaN(res.l))res.l=3D= 0;res.r=3DparseInt(res.r);if(isNaN(res.r))res.r=3D0;return = res;},getScrolls:function(){var = dim=3D{x:0,y:0};if(self.pageYOffset){dim.x=3Dself.pageXOffset;dim.y=3Dsel= f.pageYOffset;}else = if(document.documentElement){dim.x=3Ddocument.documentElement.scrollLeft;= dim.y=3Ddocument.documentElement.scrollTop;}else = if(document.body){dim.x=3Ddocument.body.scrollLeft;dim.y=3Ddocument.body.= scrollTop;}=0A= dim.x=3DparseInt(dim.x);dim.y=3DparseInt(dim.y);return = dim;},insertAfter:function(parent,node,referenceNode){parent.insertBefore= (node,referenceNode.nextSibling);},moveAfter:function(item1,item2){var = parent=3Ditem1.parentNode;parent.removeChild(item1);parent.insertBefore(i= tem1,item2?item2.nextSibling:null);},moveBefore:function(item1,item2){var= = parent=3Ditem1.parentNode;parent.removeChild(item1);parent.insertBefore(i= tem1,item2);},removeChildren:function(oObj){if(!oObj||typeof = oObj!=3D"object")return;while(oObj&&oObj.hasChildNodes()){oObj.removeChil= d(oObj.firstChild);}},removeAllChildren:function(oObj){this.removeChildre= n(oObj);},getParent:function(oEl){if(oEl){var = result=3DoEl.parentNode;while(result&&result.nodeType!=3D1)result=3Dresul= t.nextSibling;if(result)return result;}=0A= return null;},getFirstChild:function(oEl){if(oEl){var = result=3DoEl.firstChild;while(result&&result.nodeType!=3D1)result=3Dresul= t.nextSibling;if(result)return result;}=0A= return null;},getNextSibling:function(oEl,sTagName){if(oEl){var = result=3DoEl.nextSibling;if(sTagName){var = tn=3DsTagName.toUpperCase();while(result&&result.tagName!=3Dtn)result=3Dr= esult.nextSibling;}else{while(result&&result.nodeType!=3D1)result=3Dresul= t.nextSibling;}=0A= return result;}=0A= return null;},getPreviousSibling:function(oEl,sTagName){if(oEl){var = result=3DoEl.previousSibling;if(sTagName){var = tn=3DsTagName.toUpperCase();while(result&&result.tagName!=3Dtn)result=3Dr= esult.previousSibling;}else{while(result&&result.nodeType!=3D1)result=3Dr= esult.previousSibling;}=0A= return result;}=0A= return null;},nextItem:function(oEl,sNodeName){if(oEl=3D=3Dnull)return = null;var = next=3DoEl.nextSibling;while(next!=3Dnull){if(next.nodeName=3D=3DsNodeNam= e)return next;next=3Dnext.nextSibling;}=0A= return null;},previousItem:function(oEl,sNodeName){var = previous=3DoEl.previousSibling;while(previous!=3Dnull){if(previous.nodeNa= me=3D=3DsNodeName)return previous;previous=3Dprevious.previousSibling;}=0A= return null},containsNode:function(oEl,oContainer){if(oEl=3D=3Dnull)=0A= return false;if(oEl=3D=3DoContainer)=0A= return true;else=0A= return = this.containsNode(this.getParent(oEl));},getStyle:function(oEl,sStyleProp= ){if(oEl.currentStyle){return oEl.currentStyle[sStyleProp];}else = if(document.defaultView&&document.defaultView.getComputedStyle){return = document.defaultView.getComputedStyle(oEl,'').getPropertyValue(sStyleProp= );}},getSelection:function(){var = text=3D"";if(window.getSelection){text+=3Dwindow.getSelection();}else = if(document.getSelection){text+=3Ddocument.getSelection();}else = if(document.selection){text+=3Ddocument.selection.createRange().text;}=0A= return = text;},selectRange:function(oEl,iStart,iLength){if(!(oEl&&oEl.value))retu= rn;if(oEl.createTextRange){var = oRange=3DoEl.createTextRange();oRange.moveStart("character",iStart);oRang= e.moveEnd("character",iLength-oEl.value.length);oRange.select();}else = if(oEl.setSelectionRange){oEl.setSelectionRange(iStart,iLength);}=0A= oEl.focus();},getTextContent:function(oEl){return = oEl.textContent;},getPlural:function(iN,sSuffix){if(undefined=3D=3DsSuffi= x){return(iN>1?"s":"");}else = if("y"=3D=3DsSuffix){return(iN>1?"ies":"y");}else{return(iN>1?sSuffix+"s"= :sSuffix);}},getPeriodToString:function(iDelta){var x=3D"Error, cannot = convert '"+iDelta+"'";var = sDir;iDelta=3DparseInt(iDelta);if(iDelta<0){sDir=3D" = before";iDelta=3D-iDelta;}else=0A= sDir=3D" ago";var iS=3DparseInt(iDelta/1000);var = iM,iH,iD;if(iS<60){x=3DiS+" = second"+this.getPlural(iS);}else{iM=3DparseInt(iS/60);if(iM<60){x=3DiM+" = minute"+this.getPlural(iM);}else{iH=3DparseInt(iM/60);if(iH<24){iM=3DiM-i= H*60;x=3DiH+" hour"+this.getPlural(iH)+" and "+iM+" = minute"+this.getPlural(iM);}else{iD=3DparseInt(iH/24);iH-=3DiD*24;x=3DiD+= " day"+this.getPlural(iD)+" and "+iH+" hour"+this.getPlural(iH);}}}=0A= return x+sDir;},isEmail:function(sAddress){var = filter=3D/^([\w-]+(?:\.[\w-]+)*)@((?:[\w-]+\.)*\w[\w-]{0,66})\.([a-z]{2,6= }(?:\.[a-z]{2})?)$/i;return(filter.test(sAddress))},getParams:function(sS= tr,sDelim){var res=3D{};if(undefined=3D=3DsStr)return res;var = a;if(sDelim){a=3DsStr.split(sDelim);}else{if(sStr.indexOf("&")=3D=3D-= 1){a=3DsStr.split("&");}else{a=3DsStr.split("&");}}=0A= for(var i=3D0;i");this.oLoaded.push(sNewSrc);}}},sBase= :"",oLoaded:[]},insertInHtml:function(text,obj){if(document.all){obj.inne= rHTML+=3Dtext;}else{var = range=3Ddocument.createRange();range.setStartAfter(obj);var = docFrag=3Drange.createContextualFragment(text);obj.appendChild(docFrag);}= },replaceInHtml:function(text,obj){if(document.all){obj.innerHTML=3Dtext;= }else{while(obj.hasChildNodes())obj.removeChild(obj.firstChild);var = range=3Ddocument.createRange();range.setStartAfter(obj);var = docFrag=3Drange.createContextualFragment(text);obj.appendChild(docFrag);}= },drawText:function(sText,sId,add){if(!sId)sId=3D"debug";var = obj=3Ddocument.getElementById(sId);if(obj){if(add)=0A= obj.innerHTML=3D"
"+sText;else=0A= obj.innerHTML+=3DsText;}},createNewId:function(){var = newid=3Dnull;while(!newid||document.getElementById(newid)){newid=3D"XID"+= Math.round(Math.random()*65536).toString(16);}=0A= return newid;}};String.prototype.trimSpaces=3Dfunction(trimMode){var = targetString=3Dthis;var = iPos=3D0;if(!trimMode)trimMode=3D0;if(trimMode=3D=3D0||trimMode=3D=3D1){i= f(targetString.charAt(iPos)=3D=3D" = "){while(targetString.charAt(iPos)=3D=3D" = ")iPos++;targetString=3DtargetString.substr(iPos);}}=0A= iPos=3DtargetString.length-1;if(trimMode=3D=3D0||trimMode=3D=3D2){if(targ= etString.charAt(iPos)=3D=3D" "){while(targetString.charAt(iPos)=3D=3D" = ")iPos--;targetString=3DtargetString.substr(0,iPos+1);}}=0A= return targetString;}=0A= function $(){var elements=3Dnew Array();for(var = i=3D0;i""){oElements[oElements.length]=3Dels[i];}}=0A= return oElements;}=0A= function $N(name,node){var = oElements=3D[];if(node=3D=3Dnull)node=3Ddocument;var = els=3Dnode.getElementsByName(name);for(i=3D0;i""){if(rule= hash[thisName]){oThis.addRule(oThis,sActionEvent,thisName,oThis.doDataExc= hange,rulehash[thisName]);}=0A= if(activenames[thisName]){oThis.addRule(oThis,sActionEvent,thisName,oThis= .doSubmitAttribute,null);}=0A= oThis.listenForEvents(domCtrl,sActionEvent);}}finally{}};},addRule:functi= on(oThis,sEvent,sName,fFunc,oArg){var rules=3Dthis._rules;var = ename=3DsName+"$"+sEvent;var = i;if(typeof(rules[ename])!=3D'undefined'){for(i=3D0;i0)){el[0].value=3DdomTarget.get= Attribute("href");}}=0A= Dispatcher.getInstance().requestSubmit();},handleAction:function(e){var = d=3DDispatcher.getInstance();var t=3Dthis;var = i;if(t.tagName&&t.tagName.toLowerCase()=3D=3D'a'){e.preventDefault();e.st= opPropagation();}=0A= var = realname=3Dthis.getAttributeNode("realname");realname=3Drealname?realname= .value:null;if(this.name||realname){d.setSubmitSource(realname||this.name= );}=0A= d.submitCheckBegin();try{console&&console.info("Executing rule = "+t.name+"."+e.type);var = rules=3Dd.getRulesFor(t.name,e.type);for(i=3D0;rules&&(i0)){if(typeof(sourceName)=3D=3D'undefined'){console&&console.war= n("Warning: Can't identify submitter: using = p$a=3D''");}else{el[0].value=3DsourceName;}}},getSrcDst:function(oRule,oN= otifierObj){function x_FindObj(name,sid){var oResult=3D[];var = oControls=3D$N(name);for(var = i=3D0;i""?", = ":"")+oSrcDst.src[i].value;}}},SetValue:function(oListener,oRule,sMessage= ,oNotifierObj){var dispatcher=3DoListener;var = oSrcDst=3Ddispatcher.getSrcDst(oRule,oNotifierObj);for(var = j=3D0;j=3D0){dstItems.splice(position,1);}}=0A= dst.value=3DdstItems.join(", = ");}},PropertyToValue:function(oListener,oRule,sMessage,oNotifierObj){var= dispatcher=3DoListener;var = oSrcDst=3Ddispatcher.getSrcDst(oRule,oNotifierObj);for(var = j=3D0;j=3D0){prop=3Dattr.substring(ix+1);attr=3Dattr= .substring(0,ix);}=0A= var inp=3Dthis.getInputs(attr);if(!inp){return null;}=0A= if(inp.length=3D=3D1){inp=3Dinp[0];return(prop&&prop.toLowerCase()!=3D=3D= "value")?inp.getAttribute(prop):htmlutils.getValue(inp);}=0A= var result=3D[];for(var = i=3D0;i=3D0){prop=3Dattr.substring(ix+1)= ;attr=3Dattr.substring(0,ix);}=0A= if(prop){throw"UNIMPLEMENTED: Component.getList: Getting list by = property";}=0A= var inp=3Dthis.getInputs(attr);if(!inp){return null;}=0A= if(inp.length=3D=3D1){inp=3Dinp[0];return htmlutils.getList(inp);}=0A= var result=3D[];for(var = i=3D0;i=3D0){prop=3Dattr.substring(ix+1);attr=3Da= ttr.substring(0,ix);}=0A= var = inp=3Dthis.getInputs(attr);if(inp.length=3D=3D1){inp=3Dinp[0];if(prop){if= (typeof(inp[prop])!=3D'undefined'){inp[prop]=3Dvalue;}else{inp.setAttribu= te(prop,value);}}else{inp.value=3Dvalue;}}else{throw"UNIMPLEMENTED: = Cannot (yet) set vector values from = scalar";}},getInputs:function(name){var = inp=3Ddocument.getElementsByName(this.path+"."+name);if(!inp||inp.length=3D= =3D=3D0){inp=3Dnull;}=0A= return inp;},getInput:function(name){var = inp=3Dthis.getInputs(name);return((inp&&inp.length>0)?inp[0]:null);},has:= function(attrname){var = inp=3Ddocument.getElementsByName(this.path+"."+attrname);return(inp&&(inp= .length>0));},addEvent:function(inputName,eventName,f,flag){var = inputs;var = oThis=3Dthis;if(typeof(inputName)=3D=3D'string'){inputs=3Dthis.getInputs(= inputName);}else = if(utils.isArray(inputName)){inputs=3DinputName;}else{inputs=3D[inputName= ];}=0A= if(!inputs){console&&console.warn("Can't find: "+inputName);return;}=0A= var = d=3DDispatcher.getInstance();for(i=3D0;i