=20

Sk= ip to=20 main page content

=C2=A9 2010 by American = Society of Clinical=20 Oncology

Cancer Vaccines in Glioma: How to Balance the = Challenges=20 of Small Trials, Efficiency, and Potential Adverse Events

Pedro=20 R. Lowenstein

Gene Therapeutics Research Institute; Cedars-Sinai Medical = Center;=20 and David Geffen School of Medicine, University of California Los = Angeles, Los=20 Angeles, CA

High-grade glioma tumors (glioblastoma multiforme WHO grade = 4)=20 continue to carry a dire prognosis, although median survival is slowly=20 increasing. In the most recent clinical trials in high-complexity US = centers,=20 median survival is inching toward 18 to 21 months, up from 15 months in = earlier=20 trendsetting trials that showed temozolomide to be an effective addition = to the=20 standard of care of surgical resection followed by radiotherapy.^{1=E2=80=
=938=20
Nevertheless, even with optimized use of temozolomide, complete surgical =

resection, and radiotherapy, long-term survival remains elusive. Thus, =
novel=20
therapeutic approaches are being explored, and Sampson et al^{9 report=20
in this issue of Journal of Clinical Oncology that a vaccine =
against a=20
glioma antigen provides a survival advantage in a phase II trial when =
compared=20
with a cohort of contemporaneous patients.}}

The difficulties of performing large-scale clinical trials = with=20 high-grade glioma were recently highlighted by a large, multicentric,=20 randomized, controlled, double-blind phase III European trial testing = the=20 effectiveness of gene therapy by using adenoviral vectors that expressed = herpes=20 simplex virus 1 thymidine kinase followed by ganciclovir to kill = dividing glioma=20 cells as an addition to standard of care conducted by Ark Therapeutics = (London,=20 United Kingdom).^{10,11=20
Because the trial was performed at many European clinical centers, =
differences=20
in the standard of care across different countries made the assessment =
of any=20
potential benefits of the addition of gene therapy extremely =
complicated. When=20
presented with all the clinical data, the European Medicines Agency's =
Scientific=20
Advisory Group on Oncology did not approve commercialization of this =
otherwise=20
promising therapy at this stage. The reasons given were that the agency =
did not=20
consider the current study to provide sufficient evidence of clinical =
benefit,=20
and the company was advised that it must conduct a further study to show =
a=20
benefit for an end point that is clinically and statistically =
robust.^{12=E2=
=80=9314}}

Because of the spread of metastatic tumors, there remains = high=20 enthusiasm for stimulating the immune system to seek and destroy target = tumor=20 cells and improve median survival. Thus, excitement for tumor = vaccination=20 approaches received a recent boost with the US Food and Drug = Administration's=20 approval of sipuleucel-T (Provenge; Dendreon, Seattle, WA) immunotherapy = for the=20 treatment of castration-resistant prostate cancer.^{15 The=20
improved survival of 4 months for those receiving the active =
immunization=20
compared with controls was not accompanied by a measurable antitumor =
effect;=20
only one of 341 patients had a partial tumor response, and 10 patients =
had a 50%=20
reduction in prostate specific antigen values. At an estimated total =
cost of=20
$93,000 (or $23,000 per month of survival advantage with a 4-month =
median=20
increased survival) compared with conventional standard of care costs of =
$1,800=20
per month, the treatment is more likely to be used in the United States =
than in=20
other health systems. The essential challenge in evaluating ongoing =
vaccination=20
trials is that the numbers of patients receiving treatment is small, the =
results=20
are limited, and objective responses are unavailable, even when a =
statistically=20
significant survival improvement is detected. Nevertheless, the =
importance of=20
the sipuleucel-T trial was that it achieved a statistically significant=20
improvement in a randomized phase III trial=E2=80=94the gold standard of =
clinical=20
trials.^{16 Its=20
true clinical impact in the long-term treatment of castration-resistant =
prostate=20
cancer will be revealed with continued clinical use and experience.}}

The panorama of immune strategies for the treatment of = high-grade=20 glioma tumors is not much simpler to evaluate. Different = immune-therapeutic=20 approaches have been tested preclinically and are currently in = evaluation in=20 early phase I and II trials. Approaches vary from the use of autologous=20 dendritic cells loaded with tumor peptides removed from the patients' = own=20 tumors^{17=E2=
=80=9322 to=20
autologous dendritic cells loaded with synthetized potential tumor =
antigenic=20
peptides^{23=E2=
=80=9330 to=20
the use of autologous and/or allogeneic T cells engineered or selected =
to=20
recognize potential glioma antigens.^{31=E2=
=80=9336=20
Dendritic cells are usually given as vaccines to a peripheral site, =
whereas T=20
cells are either delivered systemically or into the resection cavity of =
the=20
brain tumor.}}}

Results from these trials vary, but the overall increased = survival=20 benefit obtained so far has been limited. Interestingly, although there = is a=20 potential to stimulate brain autoimmune responses as normal brain = antigens are=20 likely to be present among the peptides used to load dendritic cells, no = such=20 autoimmune responses or brain inflammation has been detected in most=20 trials.^{37=E2=
=80=9339 The=20
lack of autoimmune adverse effects has usually been taken to indicate =
the safety=20
of the dendritic cell vaccination approach. Conversely, it could also =
mean a=20
lack of efficient immunization in patients with high-grade glioma, a =
population=20
of patients already known to display systemic immune suppression. In =
comparison,=20
when patients with Alzheimer's were immunized systemically against =
=CE=B2-amyloid=20
peptides, 10% to 15% developed clinically significant brain =
inflammation, which=20
led to a suspension of the ongoing trial.^{40 Given=20
that systemic immunization against brain antigens ought to lead to =
significant=20
brain autoimmunity in at least a percentage of patients, the absence of =
such=20
responses from glioma immunotherapy trials requires further examination. =}}

Existing tumor antigens have been proposed to serve as = targets for=20 immunotherapies. A percentage of glioma tumors express a truncated = variant of=20 EGFR, known as EGFRvIII,^{26,41,42 which=20
promotes ligand-independent signaling. If EGFRvIII is indeed a driver of =

gliomas, directly attacking EGFRvIII and destroying glioma cells that =
express=20
EGFRvIII ought to provide a therapeutic benefit. To this end, Sampson et =

al^{9 report=20
the use of vaccination against a peptide derived from the mutated EGFR. =
They=20
describe the results of a phase II nonrandomized multicenter trial in =
which a=20
group of 18 patients who received treatment was compared with a =
contemporaneous=20
group of patients who did not receive treatment. The authors report an =
improved=20
progression-free survival of 6 months and improved overall survival =
(OS); the=20
median OS was 15 months in a contemporaneous, matched cohort compared =
with 26=20
months in the immunized cohort.}}

To understand the mechanisms of action in their trial, = Sampson et al=20 studied a variety of immunologic measures. Their results indicate that, = in=20 patients whose tumors are EGFRvIII positive at initial resection, an = immune=20 response can be stimulated by using the techniques described by the = authors in=20 approximately 50% of tumors. Of 17 patients who were immunized, six = developed=20 EGFRvIII antibodies, and three developed evidence of a T-cell response = against=20 EGFRvIII. Interestingly, the development of either a humoral or a = cellular=20 response to the EGFRvIII peptide appeared to be associated with = increased OS,=20 although the small numbers did not allow detailed statistical analysis. =

In addition, the authors examined EGFRvIII expression at = tumor=20 recurrence. In 11 patients who could have tumor samples evaluated both = before=20 and after vaccination, 82% of tumors lacked EGFRvIII immunoreactivity at = recurrence. The authors favor the interpretation that this indicates = tumor=20 escape, although it is impossible, at this stage, to differentiate tumor = escape=20 from loss of immunoreactivity as a result of the blocking of endogenous = EGFRvIII=20 immunoreactivity by the induced anti-EGFRvIII antibodies or = downregulation of=20 EGFRvIII expression. Although the clinical progression of the disease = would=20 support an interpretation of effective tumor control by the immunization = followed by tumor mutation and escape, the absence of more detailed = molecular=20 studies and the low number of subjects involved preclude drawing = definitive=20 conclusions. One would prefer to analyze results from large-scale, = randomized,=20 double-blind, phase III trials; however, it could be challenging to = recruit a=20 sufficient number of patients with brain tumors immunoreactive for = EGFRvIII. In=20 any case, the studies warrant future immunizations against a combination = of=20 tumor peptides to avoid or reduce the potential of tumor antigenic = escape.

Sampson et al^{9=20
demonstrate that 33% of patients who were immunized developed humoral =
responses,=20
whereas 16% developed cellular responses. Should the next step be a =
phase III=20
trial, or would it be possible to increase the response to immunization =
to=20
larger than 50% of patients preceding a larger, phase III trial? Why did =
only=20
50% of patients respond? Could this be a result of the general=20
immune-suppression of patients with gliomas or of technical details of=20
immunization procedures? Are the strongest results from this trial the =
increase=20
in OS in a nonrandomized trial or the induction of immune responses in =
50% of=20
patients? It would be important to understand the mechanisms underlying =
a=20
significant increase in OS, even if immune responses were only detected =
in 50%=20
of patients. Alternatively, the assessment of immune responses could be =
delayed=20
until a treatment is found that provides a significant OS benefit in a=20
randomized phase III trial, such as the sipuleucel-T trial for=20
castration-resistant prostate cancer. How are we to interpret that =
increased OS=20
in the sipuleucel-T trial was seen in the absence of effects on tumor=20
progression or even without stimulation of immune responses? In the case =
of=20
brain tumors, would it be worth repeating a small trial but with an =
attempt to=20
obtain direct evidence of intracranial antitumor immune reactivity, =
possibly by=20
using positron emission tomography imaging? What should be the way =
forward for=20
immunotherapies to cross the bar of generalized clinical implementation? =
The=20
field of cancer immunotherapies needs to urgently address what to look =
for in=20
such small, early, yet promising, clinical trials.}

There appear to be at least two possible ways forward. One = would be=20 to concentrate on achieving increased OS without paying too much = attention to=20 progression-free survival, tumor shrinkage, or other surrogate markers = of=20 treatment efficacy=E2=80=94all of which have their own complex = shortcomings. Once a new=20 therapy has demonstrated a clinically significant increase in OS, then = one could=20 perform further studies on how the treatment works. The second = possibility would=20 be to simultaneously look for increases in OS and examine surrogate = markers of=20 treatment efficacy. The challenge to clinical oncology is knowing how to = interpret a treatment that provides a small, yet statistically = significant=20 survival increase in the absence of compelling indications that the = treatment is=20 indeed working as expected. In the sipuleucel-T trial, the 4-month = increase in=20 survival was statistically significant, even if less than 4% of patients = showed=20 reduction in markers of tumor growth. Are such small, yet statistically=20 significant changes of true long-term clinical relevance?

Sampson et al^{9 report=20
an increased OS of 9 months compared with contemporaneous controls. If a =

comparable difference could be maintained in a larger randomized trial, =
the use=20
of the EGFRvIII vaccine in suitable patients would be amply justified. =
The=20
challenge remains how to determine the rational use of EGFRvIII vaccine =
in the=20
absence of a large, randomized, double-blind, controlled, phase III =
trial. Thus,=20
it is important to explore alternatives to study small clinical trials =
in=20
detail. For example, it would be feasible to perform further small =
clinical=20
trials that would compare various immunotherapeutic approaches against =
each=20
other and to analyze these trials by using either adaptive trial designs =
or=20
Bayesian designs that simultaneously evaluate efficacy and toxicity. =}

The clinical challenge remains how to assess whether small = survival=20 benefits are indeed clinically significant to reassure all stakeholders = that the=20 benefit is not a result of inadvertent bias. In other cases (eg, at the = early=20 stages of treatment for childhood leukemias), it was possible to = determine=20 whether, even in the absence of long-term remissions, anticancer agents=20 displayed temporary reductions in the proliferation of neoplastic cells. = Such=20 small, yet clinically significant, effects led to further improvements, = which=20 led to the ultimate reduction in the morbidity and mortality of diseases = such as=20 childhood leukemias after years of continued research. It remains the=20 responsibility of clinicians, oncologists, neurosurgeons, = neuroradiologists, and=20 basic scientists involved in glioma research to advance our statistical, = oncologic, and clinical assessment of small clinical trials to achieve = large=20 therapeutic-effect sizes that will benefit the patient community as a = whole by=20 extracting as much clinically relevant information as possible to = separate true=20 treatment effects from inadvertent experimental bias and = artifacts.⁴³

Next= =20 Section

AUTHOR'S DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

The author(s) indicated no potential conflicts of = interest.

Prev= ious=20 Section Next=20 Section

Acknowledgment

Supported by the National Institutes of Health (Bethesda, = MD), the=20 Board of Governors at Cedars-Sinai Medical Center (Los Angeles, CA), the = Joseph=20 Drown Foundation (Los Angeles, CA), and the Bram and Elaine Goldsmith = Chair in=20 Gene Therapeutics. I thank Kurt Kroeger and Maria Castro for editorial = comments.=20

Prev= ious=20 Section Next=20 Section

Footnotes

See accompanying article on page 4722=

Previous=20 Section

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What's=20 this?

ORIGINAL=20 REPORTS - Neurooncology: Immunologic Escape After Prolonged Progression-Free = Survival=20 With Epidermal Growth Factor Receptor Variant III Peptide Vaccination = in=20 Patients With Newly Diagnosed Glioblastoma

John H.=20 Sampson,
Amy B.=20 Heimberger,
Gary E. = Archer,
Kenneth D.=20 Aldape,
Allan H.=20 Friedman,
Henry S.=20 Friedman,
Mark R. = Gilbert,
James E. Herndon=20 II,
Roger E.=20 McLendon,
Duane A.=20 Mitchell,
David A. = Reardon,
Raymond = Sawaya,
Robert J.=20 Schmittling, =
Weiming = Shi,
James J.=20 Vredenburgh, =
and=20 Darell D. = Bigner=20

JCO Nov=20 1, 2010:4722-4729; published = online on=20 October 4, 2010;=20

[Abstract]=20
[Full=20 Text]=20
[PDF]=20

=C2=AB = Previous | Next Article = =C2=BBTable of = Contents=20

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Published=20 online before print October 4,=20 2010, doi: 10.1200/JCO.2010.32.1117=20 JCO=20 November 1, 2010 vol. 28 no. 31 4670-4673=20

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$(this).attr("id");=0A= /* allow em-link or em{\d+} */=0A= if ((spanClass !=3D undefined) && = (spanClass.match(/em((\d+)|(-link))/)) ||=0A= (spanId !=3D undefined) && (spanId.match(/em\d+/)))=0A= {=0A= var addr;=0A= var addrEl =3D $(this).children(".em-addr");=0A= if (addrEl.length) {=0A= addr =3D addrEl.text().replace(/{at}/,'@');=0A= }=0A= else {=0A= addr =3D $(this).text().replace(/{at}/,'@');=0A= }=0A= var link =3D 'mailto:' + addr;=0A= var linkContents =3D $(this).attr("title");=0A= var newHtml =3D '';=0A= if ((linkContents =3D=3D undefined) || !(linkContents.length)) {=0A= if ($(this).children("span.mail2-orig-content").length) {=0A= var tempSpan =3D $(this).children("span.mail2-orig-content");=0A= var classStr =3D '';=0A= =0A= var tempClassArr =3D tempSpan.attr("class").split(' ');=0A= if (tempClassArr.length > 1) {=0A= for (var i =3D 0; i < tempClassArr.length; i++) {=0A= if (tempClassArr[i] !=3D 'mail2-orig-content') {=0A= classStr +=3D (' ' + tempClassArr[i].replace(/^x-/,''));=0A= }=0A= }=0A= }=0A= linkContents =3D tempSpan.html().replace(/{at}/,'@');=0A= newHtml =3D '' + linkContents + '';=0A= }=0A= else {=0A= linkContents =3D addr;=0A= }=0A= }=0A= if (newHtml =3D=3D '') {=0A= newHtml =3D '' + linkContents + '';=0A= }=0A= $(this).replaceWith(newHtml);=0A= }=0A= }=0A= );=0A= =0A= /* make links with rel=3D"external-nw" target a new window */=0A= $("a[rel*=3Dexternal-nw]").each(=0A= function(i) {=0A= linkNewWin($(this), this);=0A= }=0A= );=0A= =0A= /* attach onFocus handlers to quick-search fields, to clear the=0A= field when it receives focus IF it contains the default=0A= value (such as "Search the site") */=0A= updateFormInput("#header-qs-search-label", "#header-qs-input", '', '');=0A= =0A= /* handle collapsing content-box areas, with user prefs */=0A= setupCollapsibles();=0A= =0A= /* handle "most" boxes */=0A= handleMostBoxes();=0A= });=0A= =0A= =0A= function linkNewWin(jQEl) {=0A= var id =3D jQEl.attr("id");=0A= var targetName =3D "_blank";=0A= var config =3D null;=0A= if ((id !=3D undefined) && id && !(id =3D=3D '') &&=0A= !(gSiteOptions.openWindowDetails =3D=3D undefined)) {=0A= var newLinkOptions =3D gSiteOptions.openWindowDetails[id];=0A= if ((newLinkOptions !=3D undefined) && newLinkOptions) {=0A= var overrideTarget =3D newLinkOptions.target;=0A= var overrideConfig =3D newLinkOptions.config;=0A= if ((overrideTarget !=3D undefined) && overrideTarget && = (overrideTarget.length > 0)) {=0A= targetName =3D overrideTarget;=0A= }=0A= if ((overrideConfig !=3D undefined) && overrideConfig && = (overrideConfig.length > 0)) {=0A= config =3D overrideConfig;=0A= }=0A= }=0A= }=0A= var origTitle =3D jQEl.attr("title");=0A= var newTitle =3D '';=0A= if ((origTitle =3D=3D undefined) || (!origTitle)) {=0A= origTitle =3D '';=0A= }=0A= else {=0A= newTitle =3D origTitle + ' ';=0A= }=0A= newTitle +=3D '[opens in a new window]';=0A= jQEl.attr("target", targetName).attr("title", newTitle);=0A= if (config !=3D null) {=0A= jQEl.click(function() {=0A= window.open(jQEl.attr("href"), targetName, config);=0A= return false;=0A= });=0A= }=0A= }=0A= =0A= function setupCollapsibles() {=0A= // sites can override this if they want to target different elements=0A= prepCollapsibles("div.content-box div.collapsible");=0A= }=0A= =0A= /* handle collapsing content-box areas, with optional user prefs */=0A= function prepCollapsibles(parentJQueryEl, setPrefs) {=0A= if (typeof(setPrefs) =3D=3D "undefined") {=0A= setPrefs =3D true;=0A= }=0A= var expandStr, contractStr;=0A= if (gSiteOptions =3D=3D undefined) {=0A= expandStr =3D '+';=0A= contractStr =3D '-';=0A= }=0A= else {=0A= if (gSiteOptions.cbExpandString !=3D undefined) {=0A= expandStr =3D gSiteOptions.cbExpandString;=0A= }=0A= else if (gSiteOptions.expandString !=3D undefined) {=0A= expandStr =3D gSiteOptions.expandString;=0A= }=0A= else { expandStr =3D '+'; }=0A= if (gSiteOptions.cbContractString !=3D undefined) {=0A= contractStr =3D gSiteOptions.cbContractString;=0A= }=0A= else if (gSiteOptions.contractString !=3D undefined) {=0A= contractStr =3D gSiteOptions.contractString;=0A= }=0A= else { contractStr =3D '-'; }=0A= }=0A= $(parentJQueryEl).each(=0A= function(i) {=0A= var $this =3D $(this);=0A= var id =3D $this.attr("id");=0A= if (id !=3D null) {=0A= var $labelElement, $label;=0A= for (var i =3D 0; i < gSiteOptions.collapsibleLabels.length; i++) {=0A= $labelElement =3D gSiteOptions.collapsibleLabels[i];=0A= $label =3D $this.find($labelElement);=0A= if ($label.length) {=0A= // get first one=0A= if ($label.length > 1) {=0A= $label =3D $label.eq(0);=0A= }=0A= break;=0A= }=0A= }=0A= =0A= // if there's already a toggle leave this as is=0A= var alreadyHasToggle =3D ($label.length && = $label.find("a.collapse-toggle").length);=0A= if ($label.length) {=0A= if (!(alreadyHasToggle)) {=0A= var labelText =3D $label.html();=0A= $label.empty().append('' + contractStr + = ' ' + labelText + '');=0A= }=0A= }=0A= =0A= var isOpen =3D true;=0A= if (setPrefs) {=0A= var statePref =3D getPrefValue(id + "-state");=0A= if (statePref && ((statePref =3D=3D 'open') || (statePref =3D=3D = 'closed'))) {=0A= if (statePref =3D=3D 'closed') {=0A= isOpen =3D false;=0A= }=0A= }=0A= else {=0A= // no pref, or unknown value=0A= if ($this.hasClass('default-closed')) {=0A= isOpen =3D false;=0A= }=0A= }=0A= }=0A= var childListType;=0A= if ($this.children("ol").length) {=0A= childListType =3D "ol";=0A= }=0A= else {=0A= childListType =3D "ul";=0A= }=0A= if (!isOpen && !(alreadyHasToggle)) {=0A= toggleCollapse($this, childListType, ($labelElement + " a = span.view-more"), expandStr, contractStr);=0A= }=0A= $this.find("a.collapse-toggle").click(=0A= function(e) {=0A= // need to find first parent that is in either state...=0A= // $(this).parents(".collapsible, .collapsed").each(=0A= $(this).parents().each(=0A= function(i) {=0A= if ($(this).hasClass('collapsible') || = $(this).hasClass('collapsed')) {=0A= var isCollapsed =3D $this.hasClass('collapsed');=0A= if (setPrefs) {=0A= var prefName =3D id + "-state";=0A= if (isCollapsed) {=0A= setPref(prefName, "open");=0A= }=0A= else {=0A= setPref(prefName, "closed");=0A= }=0A= }=0A= toggleCollapse($(this), childListType, ($labelElement + " a = span.view-more"), expandStr, contractStr);=0A= fixColHeights(-1);=0A= return false;=0A= }=0A= }=0A= );=0A= e.preventDefault();=0A= }=0A= );=0A= }=0A= }=0A= );=0A= }=0A= =0A= function handleMostBoxes() {=0A= var hadMostBoxes =3D false;=0A= $("div.most-links-box").each(=0A= function(i) {=0A= var $this =3D $(this);=0A= modClass($this, '', 'js-marker');=0A= hadMostBoxes =3D true;=0A= // 1) get the

child:=0A= var hasSelected =3D false;=0A= var mostHdrList =3D null;=0A= if ($mostlist.length) {=0A= var hasItems =3D false;=0A= var hdrList =3D '
';=0A= var $mostli =3D $mostlist.children("li");=0A= if ($mostli.length) {=0A= hasItems =3D true;=0A= $mostli.each(=0A= function(i) {=0A= var $hdr =3D $(this).children("h4").html();=0A= if ($(this).hasClass("most-cur-sel")) {=0A= hasSelected =3D true;=0A= hdrList +=3D '
' + $hdr + '
';=0A= }=0A= else {=0A= hdrList +=3D '
' + $hdr + '
';=0A= }=0A= }=0A= );=0A= }=0A= hdrList +=3D '
';=0A= if (hasItems) {=0A= var header =3D $this.find("div.most-header h3");=0A= if (header.length) {=0A= header.after(hdrList);=0A= }=0A= }=0A= mostHdrList =3D $this.find("div.most-header ul");=0A= }=0A= // 3) if none of the items are selected, make the first one be=0A= if (((mostHdrList !=3D null) && mostHdrList.length) && = (!hasSelected)) {=0A= modClass(mostHdrList.find("li:first"), "most-cur-sel", "");=0A= modClass($this.children("ul").children("li:first"), "most-cur-sel", = "");=0A= }=0A= // 4) bind a handler to each heading li a to toggle = class=3D"most-cur-sel" for =0A= // that item and its corresponding item in the list below=0A= if (((mostHdrList !=3D null) && mostHdrList.length)) {=0A= mostHdrList.find("li a").click(=0A= function(e) {=0A= var curA =3D $(this);=0A= toggleMostSelection(e, $this, curA.text());=0A= }=0A= );=0A= }=0A= }=0A= );=0A= if (hadMostBoxes) {=0A= fixColHeights(-1);=0A= }=0A= }=0A= =0A= function toggleMostSelection(e, mostItemDiv, groupName) {=0A= if (mostItemDiv.length) {=0A= var hdrItems =3D mostItemDiv.find("div.most-header ul li");=0A= if (hdrItems.length) {=0A= hdrItems.each(=0A= function() {=0A= var hdrName =3D $(this).text();=0A= var isChoice =3D (hdrName =3D=3D groupName);=0A= if (isChoice) {=0A= modClass($(this), 'most-cur-sel', '');=0A= }=0A= else {=0A= modClass($(this), '', 'most-cur-sel');=0A= }=0A= }=0A= );=0A= }=0A= var listItems =3D mostItemDiv.children("ul").find("li");=0A= if (listItems.length) {=0A= listItems.each(=0A= function() {=0A= var itemName =3D $(this).children("h4").text();=0A= var isChoice =3D (itemName =3D=3D groupName);=0A= if (isChoice) {=0A= modClass($(this), 'most-cur-sel', '');=0A= }=0A= else {=0A= modClass($(this), '', 'most-cur-sel');=0A= }=0A= }=0A= );=0A= }=0A= }=0A= fixColHeights(-1);=0A= e.preventDefault();=0A= }=0A= =0A= function toggleCollapse(collapsibleEl, hideTagExpr, modTextTagExpr, = expandStr, contractStr) {=0A= if (typeof(expandStr) =3D=3D "undefined") {=0A= expandStr =3D getSiteOption('expandString','+');=0A= }=0A= if (typeof(contractStr) =3D=3D "undefined") {=0A= contractStr =3D getSiteOption('contractString','-');=0A= }=0A= =0A= var $this =3D collapsibleEl;=0A= if ($this.hasClass('collapsed')) {=0A= modClass($this, 'collapsible', 'collapsed');=0A= }=0A= else if ($this.hasClass('collapsible')) {=0A= modClass($this, 'collapsed', 'collapsible');=0A= }=0A= var $toToggle =3D $this.find(hideTagExpr);=0A= if ($toToggle.length) {=0A= $toToggle.toggle();=0A= }=0A= var $rewrite =3D $this.find(modTextTagExpr);=0A= if ($rewrite.length) {=0A= $rewrite.each(=0A= function(i, e) {=0A= var txt =3D $(e).text();=0A= if (txt =3D=3D expandStr) {=0A= $(e).empty().append(contractStr);=0A= }=0A= else if (txt =3D=3D contractStr) {=0A= $(e).empty().append(expandStr);=0A= }=0A= }=0A= );=0A= }=0A= }=0A= =0A= function setupDockBlock(col, dockId, dockClass, contentRules) {=0A= if ((col =3D=3D 2) || (col =3D=3D 3)) {=0A= var navOrigHeight =3D ((col =3D=3D 2) ? gColOrigHeights.col2 : = gColOrigHeights.col3);=0A= var gColNum =3D col;=0A= var gNav =3D ((col =3D=3D 2) ? gCol2 : gCol3);=0A= var gNavHeight =3D ((gNav.length) ? navOrigHeight : 0);=0A= var gNavTopOffset =3D (gNavHeight > 0 ? gNav.offset().top : 0);=0A= var gScrollPos =3D 0;=0A= var gNavDocked =3D false;=0A= /* this won't work in IE 6, so skip it /=0A= / article navigation docking block /=0A= $(window).scroll(function () {=0A= if (gNavHeight > 0 && !isIE6) {=0A= var offsets =3D getPageOffset();=0A= var origHeight =3D ((gColNum =3D=3D 2) ? gColOrigHeights.col2 : = gColOrigHeights.col3);=0A= var navBottom =3D (gNavTopOffset + origHeight) - offsets.y;=0A= if (gScrollPos !=3D offsets.y) {=0A= gScrollPos =3D offsets.y;=0A= if ((navBottom <=3D 0) && !gNavDocked) {=0A= / dock the nav /=0A= gNavDocked =3D true;=0A= addDockBlock(col, dockId, dockClass, contentRules);=0A= addDockBlockCallback(dockId);=0A= }=0A= else if (gNavDocked && (navBottom > 0)) {=0A= / undock the nav /=0A= gNavDocked =3D false;=0A= removeDockBlock(col, dockId);=0A= removeDockBlockCallback(dockId);=0A= }=0A= }=0A= }=0A= });=0A= }=0A= }=0A= function addDockBlock(col, dockId, dockClass, contentRules) {=0A= // get direct children li elements only=0A= var colId =3D ("col-" + col);=0A= var newDiv =3D ' 1) {=0A= for (var i =3D 0; i < (contentRules.length - 1); i =3D i + 2) {=0A= var addTo =3D processDockingRule(contentRules[i]);=0A= var add =3D processDockingRule(contentRules[i + 1]);=0A= var addTarget, addVal;=0A= if (addTo.ruleType =3D=3D 'empty') {=0A= addTarget =3D newDivJQuery;=0A= }=0A= else if (addTo.ruleType =3D=3D 'jQuery') {=0A= addTarget =3D $(addTo.rule);=0A= }=0A= if (add.ruleType =3D 'jQuery') {=0A= var addJQEl =3D $(add.rule);=0A= if (addJQEl.length) {=0A= addVal =3D addJQEl.clone();=0A= }=0A= else {=0A= addVal =3D '';=0A= }=0A= }=0A= else if (add.ruleType =3D 'html') {=0A= addVal =3D add.rule;=0A= }=0A= if (addTarget.length && !(addVal =3D=3D '')) {=0A= addTarget.append(addVal);=0A= }=0A= else {=0A= }=0A= }=0A= }=0A= var newDockJQrule =3D "#" + colId + " #" + dockId;=0A= var newDock =3D $(newDockJQrule);=0A= if (newDock.length) {=0A= prepCollapsibles(newDockJQrule + " div.collapsible, " + newDockJQrule = + " div.collapsed", false);=0A= newDock.fadeIn(250);=0A= }=0A= }=0A= =0A= function processDockingRule(rule) {=0A= var retObj =3D new Object();=0A= retObj.empty =3D (((rule !=3D undefined) && (!(rule =3D=3D ''))) ? = false : true);=0A= if (rule =3D=3D '') {=0A= retObj.ruleType =3D 'empty';=0A= }=0A= else if (/^\$$.+$$/.test(rule)) {=0A= retObj.ruleType =3D 'jQuery';=0A= retObj.rule =3D rule.replace(/^\$$(.+)$$/,"$1");=0A= }=0A= else {=0A= retObj.ruleType =3D 'html';=0A= retObj.rule =3D rule;=0A= }=0A= return retObj;=0A= }=0A= =0A= function removeDockBlock(col, dockId) {=0A= var dockedNav =3D $("div#" + dockId);=0A= if(dockedNav.length) {=0A= dockedNav.fadeOut(250, function() { dockedNav.remove(); });=0A= }=0A= }=0A= // custom implementations can override this function to do something = when a dockBlock is added=0A= // they should return false if they want to stop any additional default = handling=0A= function customAddDockBlockCallback(dockId) {=0A= return true;=0A= }=0A= // this function should not be overridden=0A= function addDockBlockCallback(dockId) {=0A= if (customAddDockBlockCallback(dockId) !=3D false) {=0A= // no default handling, currently=0A= }=0A= }=0A= // custom implementations can override this function to do something = when a dockBlock is removed=0A= // they should return false if they want to stop any additional default = handling=0A= function customRemoveDockBlockCallback(dockId) {=0A= return true;=0A= }=0A= // this function should not be overridden=0A= function removeDockBlockCallback(dockId) {=0A= if (customRemoveDockBlockCallback(dockId) !=3D false) {=0A= // no default handling, currently=0A= }=0A= }=0A= =0A= function updateFormInput(labelMatchString, inputMatchString, = defaultColorString, textColorString) {=0A= if ((defaultColorString =3D=3D null) || (defaultColorString =3D=3D '')) = {=0A= defaultColorString =3D "#A0A0A0";=0A= }=0A= if ((textColorString =3D=3D null) || (textColorString =3D=3D '')) {=0A= textColorString =3D "black";=0A= }=0A= var label =3D $(labelMatchString);=0A= var input =3D $(inputMatchString);=0A= if (input.length) {=0A= if ((label.length) && (input.val() =3D=3D '')) {=0A= input.val(label.text()).css("color",defaultColorString);=0A= }=0A= input.focus(=0A= function(e) {=0A= if ((label.length) && ($(this).val() =3D=3D label.text())) {=0A= $(this).val('').css("color",textColorString);=0A= }=0A= }=0A= );=0A= input.blur(=0A= function(e) {=0A= if ((label.length) && ($(this).val() =3D=3D '')) {=0A= $(this).val(label.text()).css("color",defaultColorString);=0A= }=0A= }=0A= );=0A= }=0A= var parentForm =3D label.parents("form").eq(0);=0A= if (parentForm.length) {=0A= parentForm.submit(=0A= function() {=0A= if ((label.length) && (input.length) && (input.val() =3D=3D = label.text())) {=0A= input.val('');=0A= }=0A= return true;=0A= }=0A= );=0A= }=0A= }=0A= =0A= function checkUnloadedImgs(lookupRule) {=0A= if (lookupRule =3D=3D null) {=0A= lookupRule =3D "img";=0A= }=0A= var imageNum =3D -1;=0A= var images =3D $(lookupRule);=0A= if (images.length) {=0A= imageNum =3D 0;=0A= images.each(=0A= function() {=0A= //if ($(this).height() =3D=3D 0) {=0A= if (this.offsetHeight =3D=3D 0) {=0A= imageNum++;=0A= }=0A= }=0A= );=0A= }=0A= return imageNum;=0A= }=0A= =0A= function fixHeightForImages(iter, numImagesToLoad, lookupRule) {=0A= if (lookupRule =3D=3D null) {=0A= lookupRule =3D "img";=0A= }=0A= if (numImagesToLoad > 0) {=0A= var lastNumImagesToLoad =3D numImagesToLoad;=0A= var newNumImagesToLoad =3D checkUnloadedImgs(lookupRule);=0A= if (newNumImagesToLoad < lastNumImagesToLoad) {=0A= fixColHeights(1);=0A= if ((newNumImagesToLoad > 0) && (iter < 10)) {=0A= setTimeout("fixHeightForImages(" + (iter+1) + "," + = newNumImagesToLoad + ",'" + lookupRule + "')", 1000);=0A= }=0A= }=0A= }=0A= }=0A= function getColInfo(colJQEl) {=0A= var colInfo =3D { valid: false, height: 0, bottom: 0, lastElBottom: 0, = extra: 0, fix: false };=0A= if (colJQEl.length) {=0A= var c =3D colJQEl.children();=0A= if (c.length) {=0A= colInfo.height =3D getObjHeight(colJQEl);=0A= colInfo.bottom =3D colJQEl.offset().top + colInfo.height;=0A= var last =3D c.eq(c.length - 1);=0A= colInfo.lastElBottom =3D last.offset().top + getObjHeight(last);=0A= colInfo.extra =3D colInfo.bottom - colInfo.lastElBottom;=0A= colInfo.valid =3D true;=0A= }=0A= }=0A= return colInfo;=0A= }=0A= function checkColHeights() {=0A= var colToFix =3D 0;=0A= if ((gIsMultiCol || gColTempResize) && ((gColOrigHeights.main + = gColOrigHeights.col2 + gColOrigHeights.col3) > 0)) {=0A= var colMainInfo =3D getColInfo(gColMain);=0A= var col2Info =3D getColInfo(gCol2);=0A= var col3Info =3D getColInfo(gCol3);=0A= if (colMainInfo.valid && (gColLows.main =3D=3D 0)) { gColLows.main =3D = colMainInfo.lastElBottom; }=0A= if (col2Info.valid && (gColLows.col2 =3D=3D 0)) { gColLows.col2 =3D = col2Info.lastElBottom; }=0A= if (col3Info.valid && (gColLows.col3 =3D=3D 0)) { gColLows.col3 =3D = col3Info.lastElBottom; }=0A= // check if low point in any column has changed=0A= if ((colMainInfo.valid) && (colMainInfo.lastElBottom !=3D = gColLows.main)) {=0A= colMainInfo.fix =3D true;=0A= }=0A= if ((col2Info.valid) && (col2Info.lastElBottom !=3D gColLows.col2)) {=0A= col2Info.fix =3D true;=0A= }=0A= if ((col3Info.valid) && (col3Info.lastElBottom !=3D gColLows.col3)) {=0A= col3Info.fix =3D true;=0A= }=0A= // check for columns not having same bottom points=0A= if ((colMainInfo.valid) &&=0A= (((col2Info.valid) && (colMainInfo.height < col2Info.height)) ||=0A= ((col3Info.valid) && (colMainInfo.height < col3Info.height)))) {=0A= colMainInfo.fix =3D true;=0A= }=0A= if ((col2Info.valid) &&=0A= (((colMainInfo.valid) && (col2Info.height < colMainInfo.height)) ||=0A= ((col3Info.valid) && (col2Info.height < col3Info.height)))) {=0A= col2Info.fix =3D true;=0A= }=0A= if ((col3Info.valid) &&=0A= (((colMainInfo.valid) && (col3Info.height < colMainInfo.height)) ||=0A= ((col2Info.valid) && (col3Info.height < col2Info.height)))) {=0A= col3Info.fix =3D true;=0A= }=0A= =0A= if (colToFix > -1) {=0A= if (colMainInfo.valid && colMainInfo.fix) {=0A= if ((col2Info.valid && col2Info.fix) || (col3Info.valid && = col3Info.fix)) {=0A= colToFix =3D -1;=0A= }=0A= else { colToFix =3D 1; }=0A= }=0A= else if (col2Info.valid && col2Info.fix) {=0A= if (col3Info.valid && col3Info.fix) {=0A= colToFix =3D -1;=0A= }=0A= else { colToFix =3D 2; }=0A= }=0A= else if (col3Info.valid && col3Info.fix) {=0A= colToFix =3D 3;=0A= }=0A= }=0A= =0A= if (colToFix !=3D 0) {=0A= fixColHeights(colToFix);=0A= }=0A= if (colMainInfo.valid) { gColLows.main =3D colMainInfo.lastElBottom; }=0A= if (col2Info.valid) { gColLows.col2 =3D col2Info.lastElBottom; }=0A= if (col3Info.valid) { gColLows.col3 =3D col3Info.lastElBottom; }=0A= }=0A= setTimeout("checkColHeights()", 5000);=0A= }=0A= function fixColHeights(colChanged) {=0A= if ((gIsMultiCol || gColTempResize) && getSiteOption('setColSizes', = true)) {=0A= var setAll =3D false;=0A= if (colChanged =3D=3D 1) {=0A= if (gColMain.length) {=0A= setObjHeight(gColMain,'auto');=0A= gColOrigHeights.main =3D getObjHeight(gColMain);=0A= }=0A= }=0A= else if (colChanged =3D=3D 2) {=0A= if (gCol2.length) {=0A= setObjHeight(gCol2,'auto');=0A= gColOrigHeights.col2 =3D getObjHeight(gCol2);=0A= }=0A= }=0A= else if (colChanged =3D=3D 3) {=0A= if (gCol3.length) {=0A= setObjHeight(gCol3,'auto');=0A= gColOrigHeights.col3 =3D getObjHeight(gCol3);=0A= }=0A= }=0A= else {=0A= if (colChanged =3D=3D -1) {=0A= // force resize all 3=0A= if (gColMain.length) { setObjHeight(gColMain,'auto'); }=0A= if (gCol2.length) { setObjHeight(gCol2,'auto'); }=0A= if (gCol3.length) { setObjHeight(gCol3,'auto'); }=0A= }=0A= gColOrigHeights.main =3D ((gColMain.length) ? = (getObjHeight(gColMain)) : 0);=0A= gColOrigHeights.col2 =3D ((gCol2.length) ? (getObjHeight(gCol2)) : 0);=0A= gColOrigHeights.col3 =3D ((gCol3.length) ? (getObjHeight(gCol3)) : 0);=0A= setAll =3D true;=0A= }=0A= if ((gColOrigHeights.main + gColOrigHeights.col2 + = gColOrigHeights.col3) > 0) {=0A= var colInfo;=0A= var maxH =3D Math.max(Math.max(gColOrigHeights.main, = gColOrigHeights.col2), gColOrigHeights.col3);=0A= if ((gColMain.length) && ((gColOrigHeights.main < maxH) || = (getObjHeight(gColMain) > maxH) || setAll)) {=0A= setObjHeight(gColMain, maxH);=0A= colInfo =3D getColInfo(gColMain);=0A= if (colInfo.valid) { gColLows.main =3D colInfo.lastElBottom; }=0A= }=0A= if ((gCol2.length) && ((gColOrigHeights.col2 < maxH) || = (getObjHeight(gCol2) > maxH) || setAll)) {=0A= setObjHeight(gCol2, maxH);=0A= colInfo =3D getColInfo(gCol2);=0A= if (colInfo.valid) { gColLows.col2 =3D colInfo.lastElBottom; }=0A= }=0A= if ((gCol3.length) && ((gColOrigHeights.col3 < maxH) || = (getObjHeight(gCol3) > maxH) || setAll)) {=0A= setObjHeight(gCol3, maxH);=0A= colInfo =3D getColInfo(gCol3);=0A= if (colInfo.valid) { gColLows.col3 =3D colInfo.lastElBottom; }=0A= }=0A= }=0A= }=0A= }=0A= =0A= function getObjHeight(obj) {=0A= if (obj instanceof jQuery) {=0A= return obj.get(0).offsetHeight;=0A= }=0A= else if (obj instanceof Array) {=0A= return obj[0].offsetHeight;=0A= }=0A= else {=0A= return obj.offsetHeight;=0A= }=0A= }=0A= function getObjWidth(obj) {=0A= if (obj instanceof jQuery) {=0A= return obj.get(0).offsetWidth;=0A= }=0A= else if (obj instanceof Array) {=0A= return obj[0].offsetWidth;=0A= }=0A= else {=0A= return obj.offsetWidth;=0A= }=0A= }=0A= function setObjHeight(obj, h) {=0A= if (typeof(h) =3D=3D 'number') {=0A= h =3D "" + h + "px";=0A= }=0A= if (obj instanceof jQuery) {=0A= obj.get(0).style.height =3D h;=0A= }=0A= else if (obj instanceof Array) {=0A= obj[0].style.height =3D h;=0A= }=0A= else {=0A= obj.style.height =3D h;=0A= }=0A= }=0A= function setObjWidth(obj, w) {=0A= if (typeof(w) =3D=3D 'number') {=0A= w =3D "" + w + "px";=0A= }=0A= if (obj instanceof jQuery) {=0A= obj.get(0).style.width =3D w;=0A= }=0A= else if (obj instanceof Array) {=0A= obj[0].style.width =3D w;=0A= }=0A= else {=0A= obj.style.width =3D w;=0A= }=0A= }=0A= =0A= / num pixels top of page has been scrolled offscreen /=0A= function getPageOffset() {=0A= var offset =3D new Object();=0A= if( typeof( window.pageXOffset ) =3D=3D 'number' ) {=0A= offset.x =3D window.pageXOffset;=0A= offset.y =3D window.pageYOffset;=0A= } else if( document.body && ( document.body.scrollTop ) ) {=0A= offset.x =3D document.body.scrollLeft;=0A= offset.y =3D document.body.scrollTop;=0A= } else if( document.documentElement && ( = document.documentElement.scrollTop ) ) {=0A= offset.x =3D document.documentElement.scrollLeft;=0A= offset.y =3D document.documentElement.scrollTop;=0A= }=0A= if (typeof(offset.x)=3D=3D"undefined") { offset.x =3D 0; }=0A= if (typeof(offset.y)=3D=3D"undefined") { offset.y =3D 0; }=0A= return offset;=0A= }=0A= function getViewportDim() {=0A= var dim =3D new Object();=0A= // non-IE=0A= if (typeof window.innerWidth !=3D 'undefined') {=0A= dim.x =3D window.innerWidth;=0A= dim.y =3D window.innerHeight;=0A= }=0A= // IE6 in standards compliant mode=0A= else if (typeof document.documentElement !=3D 'undefined'=0A= && typeof document.documentElement.clientWidth !=3D=0A= 'undefined' && document.documentElement.clientWidth !=3D 0) {=0A= dim.x =3D document.documentElement.clientWidth;=0A= dim.y =3D document.documentElement.clientHeight;=0A= }=0A= // older versions of IE=0A= else {=0A= dim.x =3D document.getElementsByTagName('body')[0].clientWidth;=0A= dim.y =3D document.getElementsByTagName('body')[0].clientHeight;=0A= }=0A= return dim;=0A= }=0A= =0A= function newWindowTargets() {=0A= var newWins =3D $("a.in-nw");=0A= if (newWins.length) {=0A= newWins.each(=0A= function() {=0A= var $this =3D $(this);=0A= $this.attr("target", "_blank");=0A= modClass($this, 'in-nw-vis', 'in-nw');=0A= }=0A= );=0A= }=0A= }=0A= =0A= function getSiteOption(optionName, defaultVal) {=0A= if (typeof(defaultVal) =3D=3D "undefined") {=0A= defaultVal =3D gSiteOptionUnknown;=0A= }=0A= if (gSiteOptions =3D=3D undefined) {=0A= return defaultVal;=0A= }=0A= else if (gSiteOptions[optionName] =3D=3D undefined) {=0A= return defaultVal;=0A= }=0A= else {=0A= return gSiteOptions[optionName];=0A= }=0A= }=0A= =0A= function addPartHeaders(req) {=0A= req.setRequestHeader('Accept', 'application/xhtml+xml');=0A= req.setRequestHeader('Range', 'part=3Dvariant-contents');=0A= }=0A= function addCommonHeaders(req) {=0A= if (typeof(callbackToken) !=3D 'undefined') {=0A= req.setRequestHeader('X-Token', callbackToken);=0A= }=0A= }=0A= function allowsCookies() {=0A= if (hasTestCookie()) {=0A= return true;=0A= }=0A= else {=0A= setTestCookie();=0A= return hasTestCookie();=0A= }=0A= }=0A= function setTestCookie() {=0A= setCookie('cks','allowed',7,'/',null,null);=0A= }=0A= function hasTestCookie() {=0A= var ckVal =3D getCookie('cks');=0A= if ((ckVal !=3D null) && (ckVal =3D=3D 'allowed')) {=0A= return true;=0A= }=0A= else {=0A= return false;=0A= }=0A= }=0A= =0A= var UIPrefsCk=3D{=0A= name: "UIPrefs",=0A= expDays: 3652,=0A= path: '/'=0A= };=0A= =0A= function prefDefined(name) {=0A= var val =3D getPrefValue(name);=0A= if (val =3D=3D null) {=0A= return false;=0A= }=0A= else {=0A= return true;=0A= }=0A= }=0A= function getPrefValue(name) {=0A= var prefArray =3D getPrefArray();=0A= if (prefArray) {=0A= name =3D convertPrefString(name);=0A= var match =3D name + ":";=0A= for (var i =3D 0; i < prefArray.length; i++) {=0A= if (prefArray[i].indexOf(match) =3D=3D 0) {=0A= return prefArray[i].substring(match.length);=0A= }=0A= else if (prefArray[i] =3D=3D name) {=0A= // name only, no value, return boolean true=0A= return true;=0A= }=0A= }=0A= }=0A= return null;=0A= }=0A= function convertPrefString(str) {=0A= if (str) {=0A= return str.replace(/[,:=3D]/g,"");=0A= }=0A= return str;=0A= }=0A= function removePref(name) {=0A= var prefArray =3D getPrefArray();=0A= name =3D convertPrefString(name);=0A= if (prefDefined(name)) {=0A= var newArray =3D new Array(prefArray.length - 1);=0A= var match =3D name + ":";=0A= var newArrIndex =3D 0;=0A= for (var i =3D 0; i < prefArray.length; i++) {=0A= if (!((prefArray[i].indexOf(match) =3D=3D 0) || (prefArray[i] =3D=3D = name))) {=0A= newArray[newArrIndex++] =3D prefArray[i];=0A= }=0A= }=0A= setPrefCookie(newArray);=0A= if (prefArray.length =3D=3D 1) {=0A= return null;=0A= }=0A= else {=0A= return newArray;=0A= }=0A= }=0A= else {=0A= return prefArray;=0A= }=0A= }=0A= =0A= function setPref(name, value) {=0A= if (typeof(value) =3D=3D "undefined") {=0A= value =3D null;=0A= }=0A= if (name) {=0A= name =3D convertPrefString(name);=0A= var prefArray =3D removePref(name);=0A= if (prefArray =3D=3D null) {=0A= prefArray =3D new Array;=0A= }=0A= var newArray =3D new Array(prefArray.length + 1);=0A= var newPref =3D name + (((value !=3D null) && (value !=3D '')) ? (':' = + value) : '');=0A= newArray[0] =3D newPref;=0A= for (var i =3D 0; i < prefArray.length; i++) {=0A= newArray[i+1] =3D prefArray[i];=0A= }=0A= setPrefCookie(newArray);=0A= return newArray;=0A= }=0A= else {=0A= return getPrefArray();=0A= }=0A= }=0A= function setPrefCookie(prefs) {=0A= if (prefs && (prefs.length > 0)) {=0A= var prefString;=0A= if (typeof(prefs) =3D=3D 'string') {=0A= prefString =3D prefs;=0A= }=0A= else {=0A= if (prefs.length =3D=3D 1) {=0A= prefString =3D prefs[0];=0A= }=0A= else {=0A= prefString =3D prefs.join(',');=0A= }=0A= }=0A= setCookie(UIPrefsCk.name, prefString, UIPrefsCk.expDays, = UIPrefsCk.path, false, false);=0A= }=0A= else {=0A= deleteCookie(UIPrefsCk.name, UIPrefsCk.path, false);=0A= }=0A= }=0A= // individual pref items in the cookie are separated by ',' and=0A= // nv pref pairs are joined by ':', i.e. n1:v1,n2:v2,n3:v3,etc.=0A= // values are optional. (i.e. "n1,n2:v2,n3" is ok)=0A= function getPrefArray() {=0A= var cookieVal =3D getCookie(UIPrefsCk.name);=0A= if (cookieVal !=3D null) {=0A= return cookieVal.split(',');=0A= }=0A= return null;=0A= }=0A= =0A= // http://www.dustindiaz.com/top-ten-javascript/=0A= function getCookie( name ) {=0A= var start =3D document.cookie.indexOf( name + "=3D" );=0A= var len =3D start + name.length + 1;=0A= if (((!start ) && (name !=3D document.cookie.substring( 0, name.length = ))) || (start =3D=3D -1)) {=0A= return null;=0A= }=0A= var end =3D document.cookie.indexOf( ';', len );=0A= if ( end =3D=3D -1 ) end =3D document.cookie.length;=0A= return unescape( document.cookie.substring( len, end ) );=0A= }=0A= function setCookie( name, value, expires, path, domain, secure ) {=0A= var today =3D new Date();=0A= today.setTime( today.getTime() );=0A= if ( expires ) {=0A= expires =3D expires 1000 * 60 * 60 * 24;=0A= }=0A= var expires_date =3D new Date( today.getTime() + (expires) );=0A= document.cookie =3D name+'=3D'+escape( value ) +=0A= ( ( expires ) ? ';expires=3D'+expires_date.toGMTString() : '' ) +=0A= ( ( path ) ? ';path=3D' + path : '' ) +=0A= ( ( domain ) ? ';domain=3D' + domain : '' ) +=0A= ( ( secure ) ? ';secure' : '' );=0A= }=0A= =0A= function deleteCookie( name, path, domain ) {=0A= if ( getCookie( name ) ) document.cookie =3D name + '=3D' +=0A= ( ( path ) ? ';path=3D' + path : '') +=0A= ( ( domain ) ? ';domain=3D' + domain : '' ) +=0A= ';expires=3DThu, 01-Jan-1970 00:00:01 GMT';=0A= }=0A= function modClass(jQueryEl, addClass, removeClass) {=0A= if (jQueryEl.length) {=0A= var exClass =3D jQueryEl.attr("class");=0A= var classArr =3D new Array;=0A= if ((exClass !=3D undefined) && (exClass !=3D '')) {=0A= classArr =3D exClass.split(' ');=0A= }=0A= var newClass =3D '';=0A= var addClassExisted =3D false;=0A= for (var i =3D 0; i < classArr.length; i++) {=0A= var classPart =3D classArr[i];=0A= if (classPart !=3D '') { =0A= if (classPart !=3D removeClass) {=0A= if (classPart =3D=3D addClass) {=0A= addClassExisted =3D true;=0A= }=0A= newClass =3D addToDelimString(newClass, classPart, ' ');=0A= }=0A= }=0A= }=0A= if (!addClassExisted) {=0A= newClass =3D addToDelimString(newClass, addClass, ' ');=0A= }=0A= jQueryEl.attr("class",newClass);=0A= }=0A= }=0A= function addToDelimString(origString, newPart, delim) {=0A= var newString;=0A= if ((origString =3D=3D undefined) || (origString =3D=3D '')) {=0A= newString =3D newPart;=0A= }=0A= else {=0A= newString =3D origString + delim + newPart;=0A= }=0A= return newString;=0A= }=0A= function debugOut(msg) {=0A= if(window.console) {=0A= window.console.log(msg);=0A= } =0A= /=0A= else {=0A= alert(msg);=0A= }=0A= /=0A= } ------=_NextPart_000_0000_01CB7AB8.6C428120 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jco.ascopubs.org/shared/js/design/hw-design1.js $(document).ready(function() {=0A= // updateFormInput(labelMatchString, inputMatchString, = defaultColorString, textColorString) {=0A= var inputSuggColor=3D"#A0A0A0"=0A= $("#hdr-login input").css("color",inputSuggColor);=0A= $("#hdr-login input").each( function(){=0A= var myid =3D $(this).attr("id");=0A= var labelmatch =3D "#hdr-login label[for=3D'"+myid+"']";=0A= var mylabel =3D $(labelmatch);=0A= if (mylabel.length) {=0A= $(this).val(mylabel.text()).css("color",inputSuggColor);=0A= }=0A= })=0A= $("#hdr-login input").focus(=0A= function(e) {=0A= var myid =3D $(this).attr("id");=0A= var labelmatch =3D "#hdr-login label[for=3D'"+myid+"']";=0A= var mylabel =3D $(labelmatch);=0A= if (mylabel.length && $(this).val() =3D=3D mylabel.text()) {=0A= $(this).val('').css("color","black");=0A= }=0A= }=0A= );=0A= $("#hdr-login input").blur(=0A= function(e) {=0A= if ($(this).val() =3D=3D '') {=0A= var myid =3D $(this).attr("id");=0A= var labelmatch =3D "#hdr-login label[for=3D'"+myid+"']";=0A= var mylabel =3D $(labelmatch);=0A= if (mylabel.length) {=0A= $(this).val(mylabel.text()).css("color",inputSuggColor);=0A= }=0A= }=0A= }=0A= );=0A= $("#hdr-login-signin-label").wrap('').click(=0A= function(e) {=0A= $("#hdr-login form").submit();=0A= }=0A= );=0A= =0A= // moved to hw-shared=0A= // updateFormInput("#header-qs-search-label", "#header-qs-input", '', = '');=0A= =0A= $("#header div.header-qs label[for=3D'header-qs-search']").wrap('').click(=0A= function(e) {=0A= $("#header div.header-qs form").submit();=0A= }=0A= );=0A= =0A= });=0A= ------=_NextPart_000_0000_01CB7AB8.6C428120 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jco.ascopubs.org/shared/js/pages/hw-content.js /* jQuery javascript functions for content page /=0A= var gIsFrameset =3D false;=0A= var gIsOMContent;=0A= var gAuthorAffilparam1 =3D "div.article div.contributors = p.affiliation-list-reveal a.view-more";=0A= var gAuthorAffilparam2 =3D "div.article div.contributors = ol.contributor-list a[href^=3D'#aff']";=0A= =0A= $(document).ready(function() {=0A= =0A= var pgDiv =3D $("div#pageid-content");=0A= gIsOMContent =3D (pgDiv.length && = pgDiv.hasClass("hwp-metaport-content"));=0A= =0A= if (!(getSiteOption("noAuthAffilCollapse") =3D=3D true)) {=0A= handleAuthAffil(gAuthorAffilparam1,gAuthorAffilparam2);=0A= }=0A= =0A= fixWackyReflinksMarkup();=0A= =0A= var defaultDockedNavRules =3D [=0A= '', '
This Article
',=0A= '$(#col-2 #docked-nav-views)', '$(#article-cb-main .cb-section = ol:has(li a[rel^=3D"view-"]) > li)',=0A= '$(#col-2 #docked-nav #docked-slug li)', '$(#col-2 #slugline)',=0A= '', '$(#article-dyn-nav)'=0A= ];=0A= =0A= if (!(getSiteOption("suppressDockedNav") =3D=3D true)) {=0A= setupDockBlock(2, 'docked-nav', 'dockblock', defaultDockedNavRules);=0A= }=0A= =0A= if (!(getSiteOption("noPDFExtractExpand") =3D=3D true)) {=0A= linkPDFExtImg();=0A= }=0A= =0A= var unloadedImgLookupRule =3D "div.article div.fig img";=0A= var numImagesToLoad =3D checkUnloadedImgs(unloadedImgLookupRule);=0A= =0A= / ref rollover /=0A= if (!(getSiteOption("suppressRefPopups") =3D=3D true)) {=0A= setTimeout("addRefPops()", 25);=0A= }=0A= =0A= / fig-expansion in page /=0A= if (!(getSiteOption("noInlineFigExpand") =3D=3D true) && (!gIsOMContent = || (gIsOMContent && (getSiteOption("inlineFigExpandOMContent") =3D=3D = true)))) {=0A= setTimeout("figExpandInline()", 10);=0A= }=0A= =0A= / if configured, open ref links in new windows /=0A= if (getSiteOption("refLinksNewWindow") =3D=3D true) {=0A= setTimeout("refLinksNewWindowTarget()", 25);=0A= }=0A= =0A= / 'new window' fig expansions /=0A= setTimeout("newWindowTargets()", 25);=0A= =0A= / AJAX related article callbacks /=0A= setTimeout("getISIRelated()", 50);=0A= =0A= / AJAX citing article callbacks /=0A= setTimeout("getHWCiting()", 50);=0A= setTimeout("getCiting('isi','Loading Web of Science citing article = data...', '', " + addISICiting + ")", 50);=0A= setTimeout("getCiting('scopus','Loading Scopus citing article data...', = 'callback/'," + addScopusCiting + ")", 50);=0A= =0A= / AJAX Entrez Links callbacks /=0A= setTimeout("getEntrezLinks()", 50);=0A= =0A= / Related content /=0A= setTimeout("getHWRelatedURLs()", 50);=0A= setTimeout("getPatientInformData()", 50);=0A= =0A= / Fix col heights for images /=0A= setTimeout("fixHeightForImages(1" + "," + numImagesToLoad + ", '" + = unloadedImgLookupRule + "')",1000);=0A= =0A= / Social Bookmarking enhancement /=0A= setTimeout("updateSBLinks()", 100);=0A= =0A= });=0A= =0A= function handleAuthAffil(authorAffilDivparam1,authorAffilDivparam2) {=0A= var authAffilMatch =3D getSiteOption('authAffilMatch','div.article = div.contributors ol.affiliation-list'); =0A= var authAffil =3D (authAffilMatch !=3D undefined) ? $(authAffilMatch) : = '';=0A= var disableIfMultAffils =3D = getSiteOption('authAffilDisableMultipleMatches',false);=0A= if (authAffil.length && ((authAffil.length <=3D 1) || = (!disableIfMultAffils))) {=0A= var expandStr =3D getSiteOption('authExpandString', null);=0A= if (expandStr =3D=3D null) {=0A= expandStr =3D getSiteOption('expandString', '+');=0A= }=0A= var contractStr =3D getSiteOption('authContractString', null);=0A= if (contractStr =3D=3D null) {=0A= contractStr =3D getSiteOption('contractString', '-');=0A= }=0A= var newP =3D '
' + expandStr + ' Author Affiliations
';=0A= / add auth affil show/hide p /=0A= var contribLists =3D $("div.article div.contributors = ol.contributor-list");=0A= if (contribLists.length) {=0A= contribLists.after(newP);=0A= }=0A= / hide author affiliations until requested /=0A= if (authAffil.length) {=0A= authAffil.each(=0A= function (i) {=0A= modClass(authAffil.eq(i),'hideaffil','showaffil');=0A= }=0A= );=0A= }=0A= $(authorAffilDivparam1).click(=0A= function(e) {=0A= = AuthClickOne(authorAffilDivparam1,authAffilMatch,expandStr,contractStr,e)= ;=0A= }=0A= );=0A= / show author affiliations when affil link is selected /=0A= $(authorAffilDivparam2).click(=0A= function(e) {=0A= = AuthClickTwo(authorAffilDivparam2,authAffilMatch,expandStr,contractStr,e)= ;=0A= }=0A= );=0A= fixColHeights(1);=0A= }=0A= }=0A= =0A= function figExpandInline() {=0A= var figlinks =3D $("div.fig-inline:not(.video-inline) = a[href=3D'expansion']");=0A= if (figlinks.length) {=0A= figlinks.each(=0A= function() {=0A= var $this =3D $(this);=0A= var classAttr =3D $this.attr("class");=0A= if (!(classAttr && ((classAttr =3D=3D 'in-nw') || (classAttr =3D=3D = 'ppt-landing')))) {=0A= if ($this.text().indexOf('n this window') >=3D 0) {=0A= $this.text("In this page");=0A= }=0A= var parentDiv =3D $this.parents("div.fig-inline");=0A= var href =3D $this.attr("href");=0A= $(this).click(=0A= function(e) {=0A= swapFig(e, href, parentDiv);=0A= }=0A= );=0A= }=0A= }=0A= );=0A= }=0A= }=0A= =0A= function swapFig(e, href, figWrapperEl) {=0A= var host =3D document.location.protocol + "//" + document.location.host;=0A= var path =3D document.location.pathname;=0A= var pathseg =3D path.substring(0, path.lastIndexOf('/'));=0A= //var baseAjaxUrl =3D host + pathseg + '/' + href;=0A= var baseAjaxUrl;=0A= if (href.indexOf('http:' =3D=3D 0)) {=0A= baseAjaxUrl =3D href;=0A= }=0A= else {=0A= baseAjaxUrl =3D host + pathseg + '/' + href;=0A= }=0A= var ajaxUrl =3D baseAjaxUrl + ((href.indexOf('?') >=3D 0) ? '&' : '?') = + 'baseURI=3D' + ((baseAjaxUrl.indexOf('?') > 0) ? = baseAjaxUrl.substring(0, baseAjaxUrl.indexOf('?')): baseAjaxUrl);=0A= //var ajaxUrl =3D baseAjaxUrl + ((href.indexOf('?') >=3D 0) ? '&' : = '?') + 'baseURI=3D' + baseAjaxUrl;=0A= $.ajax({=0A= url: ajaxUrl,=0A= dataType: "html",=0A= type: "GET",=0A= error: ajaxErr,=0A= beforeSend: addFigHeaders,=0A= success: function(xhtml) {=0A= addFig(xhtml, figWrapperEl);=0A= },=0A= complete: ajaxComplete=0A= });=0A= e.preventDefault();=0A= }=0A= function addFigHeaders(req) {=0A= addCommonHeaders(req);=0A= addPartHeaders(req);=0A= }=0A= =0A= function addFig(xhtmlData, figWrapperEl) {=0A= if (xhtmlData && !(xhtmlData.indexOf('=3D 0)) {=0A= figWrapperEl.replaceWith(xhtmlData);=0A= newWindowTargets();=0A= var lookupRule =3D "div.article div.fig img";=0A= var numImagesToLoad =3D checkUnloadedImgs(lookupRule);=0A= setTimeout("fixHeightForImages(1" + "," + numImagesToLoad + ",'" + = lookupRule + "')", 1000);=0A= fixColHeights(1);=0A= }=0A= }=0A= =0A= function refLinksNewWindowTarget() {=0A= $("div.ref-list div.cit-extra a").each(=0A= function(i) {=0A= var origTitle =3D $(this).attr("title");=0A= var newTitle =3D '';=0A= if ((origTitle =3D=3D undefined) || (!origTitle)) {=0A= origTitle =3D '';=0A= }=0A= else {=0A= newTitle =3D origTitle + ' ';=0A= }=0A= newTitle +=3D '[opens in a new window]';=0A= $(this).attr("target", "_blank").attr("title", newTitle);=0A= }=0A= );=0A= }=0A= =0A= function addRefPops() {=0A= var numMissed =3D 0;=0A= var maxToSkip =3D getSiteOption('refPopsMaxToSkip', 10);=0A= var i =3D 1;=0A= var idroot =3D "#xref-ref-";=0A= var el =3D $(idroot + i + '-1');=0A= /* not all refs appear in text; compensate /=0A= while (numMissed < maxToSkip) {=0A= if (el.length) {=0A= numMissed =3D 0;=0A= el.hover(dispRef, hideRef);=0A= if ((getSiteOption("isIosRefPops") =3D=3D true)) {=0A= //Also set the ios version of the function=0A= el.hover(iosdispRef, hideRef);=0A= }=0A= var j =3D 2;=0A= var el2 =3D $(idroot + i + "-" + j);=0A= while (el2.length) {=0A= el.hover(dispRef, hideRef);=0A= if ((getSiteOption("isIosRefPops") =3D=3D true)) {=0A= //Also set the ios version of the function=0A= el.hover(iosdispRef, hideRef);=0A= }=0A= j++;=0A= el2 =3D $(idroot + i + "-" + j);=0A= }=0A= }=0A= else {=0A= numMissed++;=0A= }=0A= i++;=0A= el =3D $(idroot + i + "-1");=0A= }=0A= }=0A= =0A= function dispRef(e) {=0A= var link =3D $(this).attr("href");=0A= if($("div#hovering-ref").length) {=0A= $("div#hovering-ref").remove();=0A= //alert("hovering-ref div removed on new hover!");=0A= }=0A= var linkEl =3D $(link);=0A= if (linkEl.length) {=0A= var citHtml =3D linkEl.next("div").children("div.cit-metadata");=0A= if (!(citHtml.length)) {=0A= citHtml =3D linkEl.parent().next("div").children("div.cit-metadata");=0A= }=0A= if (citHtml.length) {=0A= var newDiv =3D '
' + (citHtml.clone().html()) = + '
';=0A= $("body").append(newDiv);=0A= var elH =3D getObjHeight($("div#hovering-ref"));=0A= if ((getSiteOption("isIosRefPops") =3D=3D true)) {=0A= $("div#hovering-ref").css("left", 10).css("top", = e.pageY-elH).css("position", "absolute");=0A= }=0A= else {=0A= $("div#hovering-ref").css("left", e.pageX+10).css("top", = e.pageY-elH).css("position", "absolute");=0A= }=0A= }=0A= }=0A= }=0A= =0A= function hideRef(e) {=0A= if($("div#hovering-ref").length) {=0A= $("div#hovering-ref").remove();=0A= }=0A= }=0A= =0A= function getHWCiting() {=0A= var citingA =3D $("#cb-hw-citing-articles");=0A= if (citingA.length) {=0A= var newA =3D 'Loading citing = article data...';=0A= citingA.replaceWith(newA);=0A= var href =3D citingA.attr("href");=0A= var id =3D '';=0A= if (href && (href.indexOf('?') > 0)) {=0A= var args =3D href.substring(href.indexOf('?') + 1).split('&');=0A= for (var i =3D 0; i < args.length; i++) {=0A= if (args[i].toLowerCase().indexOf('legid=3D') =3D=3D 0) {=0A= id =3D args[i].substring(args[i].indexOf('=3D') + 1);=0A= if (id.indexOf('#') > 0) {=0A= id =3D id.substring(0, id.indexOf('#'));=0A= }=0A= }=0A= }=0A= if (!(id =3D=3D '')) {=0A= var host =3D document.location.protocol + "//" + = document.location.host;=0A= var ajaxUrl =3D host + '/cited-by/' + id.replace(/;/,'/');=0A= $.ajax({=0A= url: ajaxUrl,=0A= dataType: "html",=0A= type: "GET",=0A= error: ajaxErr,=0A= success: addHWCiting,=0A= complete: ajaxComplete=0A= });=0A= =0A= }=0A= }=0A= }=0A= }=0A= function getHWRelatedURLs() {=0A= var relatedURLsA =3D $("#cb-related-urls");=0A= var relatedURLsMsg =3D = getSiteOption('relatedWebPageLoadingText','Loading related web page = data...'); =0A= if (relatedURLsA.length) {=0A= var newA =3D '' + = relatedURLsMsg + '';=0A= relatedURLsA.replaceWith(newA);=0A= var href =3D relatedURLsA.attr("href");=0A= var id =3D '';=0A= if (href && (href.indexOf('?') > 0)) {=0A= var args =3D href.substring(href.indexOf('?') + 1).split('&');=0A= for (var i =3D 0; i < args.length; i++) {=0A= if (args[i].toLowerCase().indexOf('legid=3D') =3D=3D 0) {=0A= id =3D args[i].substring(args[i].indexOf('=3D') + 1);=0A= if (id.indexOf('#') > 0) {=0A= id =3D id.substring(0, id.indexOf('#'));=0A= }=0A= }=0A= }=0A= if (!(id =3D=3D '')) {=0A= var host =3D document.location.protocol + "//" + = document.location.host;=0A= var ajaxUrl =3D host + '/related-web-pages/' + id.replace(/;/,'/');=0A= $.ajax({=0A= url: ajaxUrl,=0A= dataType: "html",=0A= type: "GET",=0A= error: ajaxErr,=0A= success: addRelatedURLs,=0A= complete: ajaxComplete=0A= });=0A= =0A= }=0A= }=0A= }=0A= }=0A= function getPatientInformData() {=0A= var pInformA =3D $("#cb-patientinform");=0A= if (pInformA.length) {=0A= var newA =3D 'Loading = patientINFORMation...';=0A= pInformA.replaceWith(newA);=0A= var href =3D pInformA.attr("href");=0A= var id =3D '';=0A= if (href && (href.indexOf('?') > 0)) {=0A= var args =3D href.substring(href.indexOf('?') + 1).split('&');=0A= for (var i =3D 0; i < args.length; i++) {=0A= if (args[i].toLowerCase().indexOf('legid=3D') =3D=3D 0) {=0A= id =3D args[i].substring(args[i].indexOf('=3D') + 1);=0A= if (id.indexOf('#') > 0) {=0A= id =3D id.substring(0, id.indexOf('#'));=0A= }=0A= }=0A= }=0A= if (!(id =3D=3D '')) {=0A= var host =3D document.location.protocol + "//" + = document.location.host;=0A= var ajaxUrl =3D host + '/related-web-pages/patientinform/' + = id.replace(/;/,'/');=0A= $.ajax({=0A= url: ajaxUrl,=0A= dataType: "html",=0A= type: "GET",=0A= error: ajaxErr,=0A= success: addPatientInform,=0A= complete: ajaxComplete=0A= });=0A= =0A= }=0A= }=0A= }=0A= }=0A= function getISIRelated() {=0A= var relatedA =3D $("#cb-isi-similar-articles");=0A= if (relatedA.length) {=0A= var newA =3D 'Loading Web = of Science article data...';=0A= relatedA.replaceWith(newA);=0A= var href =3D relatedA.attr("href");=0A= var id =3D '';=0A= if (href) {=0A= var hrefDec =3D decodeURI(href);=0A= if ((hrefDec.indexOf('?') > 0)) {=0A= var args =3D hrefDec.substring(hrefDec.indexOf('?') + 1).split('&');=0A= for (var i =3D 0; i < args.length; i++) {=0A= var argDec =3D decodeURIComponent(args[i]);=0A= if (argDec.toLowerCase().indexOf('access_num=3D') =3D=3D 0) {=0A= id =3D argDec.substring(argDec.indexOf('=3D') + 1);=0A= if (id.indexOf('#') > 0) {=0A= id =3D id.substring(0, id.indexOf('#'));=0A= }=0A= }=0A= }=0A= if (!(id =3D=3D '')) {=0A= var host =3D document.location.protocol + "//" + = document.location.host;=0A= var ajaxUrl =3D host + '/isi-links/has-related/' + = id.replace(/;/,'/');=0A= $.ajax({=0A= url: ajaxUrl,=0A= dataType: "html",=0A= type: "GET",=0A= error: ajaxErr,=0A= success: addISIRelated,=0A= complete: ajaxComplete=0A= });=0A= }=0A= }=0A= }=0A= }=0A= }=0A= function getCiting(service, msg, pathseg, successFn) {=0A= var citingA =3D $("#cb-" + service + "-citing-articles");=0A= if (citingA.length) {=0A= var newA =3D '' = + msg + '';=0A= citingA.replaceWith(newA);=0A= var href =3D citingA.attr("href");=0A= var id =3D '';=0A= if (href) {=0A= var hrefDec =3D decodeURI(href);=0A= if ((hrefDec.indexOf('?') > 0)) {=0A= var args =3D hrefDec.substring(hrefDec.indexOf('?') + 1).split('&');=0A= for (var i =3D 0; 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i < args.length; i++) {=0A= var argDec =3D decodeURIComponent(args[i]);=0A= if (argDec.toLowerCase().indexOf('access_num=3D') =3D=3D 0) {=0A= id =3D argDec.substring(argDec.indexOf('=3D') + 1);=0A= if (id.indexOf('#') > 0) {=0A= id =3D id.substring(0, id.indexOf('#'));=0A= }=0A= }=0A= }=0A= if (!(id =3D=3D '')) {=0A= var host =3D document.location.protocol + "//" + = document.location.host;=0A= var ajaxUrl =3D host + '/isi-links/' + id.replace(/;/,'/');=0A= $.ajax({=0A= url: ajaxUrl,=0A= dataType: "html",=0A= type: "GET",=0A= error: ajaxErr,=0A= success: addISICiting,=0A= complete: ajaxComplete=0A= });=0A= }=0A= }=0A= }=0A= }=0A= }=0A= function getEntrezLinks() {=0A= var entrezDiv =3D $("#cb-entrez-links-placeholder");=0A= if (entrezDiv.length) {=0A= var entrezA =3D entrezDiv.children("a");=0A= if (entrezA) {=0A= var host =3D document.location.protocol + "//" + = document.location.host;=0A= var ajaxUrl =3D host + entrezA.attr("href");=0A= $.ajax({=0A= url: ajaxUrl,=0A= dataType: "html",=0A= type: "GET",=0A= error: ajaxErr,=0A= success: addEntrezLinks,=0A= complete: ajaxComplete=0A= });=0A= }=0A= }=0A= }=0A= =0A= function ajaxErr(req, msg, e) {=0A= }=0A= function ajaxComplete(req, msg) {=0A= }=0A= function updateCBItem(cbItem, newHTML, hasData) {=0A= var parentItem =3D cbItem.parents("li").eq(0);=0A= cbItem.replaceWith(newHTML);=0A= if (!hasData) {=0A= // hide the parent li=0A= if (parentItem.length) {=0A= modClass(parentItem,"nodata","");=0A= // check if there are any siblings still being displayed=0A= var otherItems =3D parentItem.siblings();=0A= var allItemsEmpty;=0A= if (otherItems.length) {=0A= if (otherItems.length =3D=3D otherItems.filter(".nodata").length) {=0A= allItemsEmpty =3D true=0A= }=0A= else {=0A= allItemsEmpty =3D false;=0A= }=0A= }=0A= else {=0A= allItemsEmpty =3D true;=0A= }=0A= if (allItemsEmpty) {=0A= var cbsection =3D parentItem.parents("div.cb-section").eq(0);=0A= if (cbsection.length) {=0A= modClass(cbsection,"nodata","");=0A= }=0A= }=0A= }=0A= }=0A= // in frameset fix targets on child links, forms=0A= fixFrameLinks(parentItem.find("a,form"));=0A= fixColHeights(2);=0A= }=0A= function fixFrameLinks(jqItems) {=0A= if ((gIsFrameset !=3D null) && gIsFrameset) {=0A= jqItems.each(=0A= function(i) {=0A= var href =3D $(this).attr("href");=0A= var action =3D $(this).attr("action"); // if form=0A= if ((href !=3D null) || (action !=3D null)) {=0A= var inFrameAnchor =3D ((href !=3D null) && = (((/frameset=3D/.test(href)) && (/#/.test(href))) || = (href.substring(0,1) =3D=3D '#')));=0A= if ((!inFrameAnchor) || (action !=3D null)) {=0A= $(this).attr("target", "_top");=0A= }=0A= }=0A= }=0A= );=0A= }=0A= }=0A= function addRelatedURLs(xhtmlData) {=0A= var cbA =3D $("#cb-loading-related-urls");=0A= if (gIsFrameset) {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
Not = available in this view
', false);=0A= }=0A= }=0A= else if (xhtmlData && !(xhtmlData.indexOf('=3D 0)) {=0A= $("#related-urls").replaceWith(xhtmlData);=0A= var relatedWebPagesLabel =3D getSiteOption('relatedWebPagesLabel', = 'Related Web Pages');=0A= fixColHeights(1);=0A= if (cbA.length) {=0A= updateCBItem(cbA, '' + relatedWebPagesLabel = + '', true);=0A= }=0A= }=0A= else {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
No related = web pages
', false);=0A= }=0A= }=0A= }=0A= function addPatientInform(xhtmlData) {=0A= var cbA =3D $("#cb-loading-patientinform");=0A= if (gIsFrameset) {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
Not = available in this view
', false);=0A= }=0A= }=0A= else if (xhtmlData && !(xhtmlData.indexOf('=3D 0)) {=0A= $("#patientinform-links").replaceWith(xhtmlData);=0A= fixColHeights(1);=0A= if (cbA.length) {=0A= updateCBItem(cbA, 'patientINFORMation', true);=0A= }=0A= }=0A= else {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
No = patientINFORMation available for this article
', false);=0A= }=0A= }=0A= }=0A= function addHWCiting(xhtmlData) {=0A= var cbA =3D $("#cb-loading-hw-cited");=0A= if (gIsFrameset) {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
Not available = in this view
', false);=0A= }=0A= }=0A= else if (xhtmlData) {=0A= $("#content-block").append(xhtmlData);=0A= var hwCitingLabel =3D getSiteOption('hwCitingLabel', 'View citing = article information');=0A= fixColHeights(1);=0A= if (cbA.length) {=0A= updateCBItem(cbA, '' + hwCitingLabel + '', = true);=0A= }=0A= }=0A= else {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
No citing = articles
', false);=0A= }=0A= }=0A= }=0A= function addISIRelated(xhtmlData) {=0A= var cbA =3D $("#cb-isi-similar-articles");=0A= if (xhtmlData && !(xhtmlData.indexOf('=3D 0)) {=0A= if (cbA.length) {=0A= updateCBItem(cbA, xhtmlData, true);=0A= }=0A= }=0A= else {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
No Web of = Science related articles
', false);=0A= }=0A= }=0A= }=0A= function addISICiting(xhtmlData) {=0A= var cbA =3D $("#cb-loading-isi-cited");=0A= if (xhtmlData && !(xhtmlData.indexOf('=3D 0)) {=0A= if (cbA.length) {=0A= updateCBItem(cbA, xhtmlData, true);=0A= }=0A= }=0A= else {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
No Web of = Science citing articles
', false);=0A= }=0A= }=0A= }=0A= function addScopusCiting(xhtmlData) {=0A= var cbA =3D $("#cb-loading-scopus-cited");=0A= if (xhtmlData && (xhtmlData.indexOf('=3D 0)) {=0A= if (cbA.length) {=0A= updateCBItem(cbA, xhtmlData, true);=0A= }=0A= }=0A= else {=0A= if (cbA.length) {=0A= updateCBItem(cbA, '
No Scopus = citing articles
', false);=0A= }=0A= }=0A= }=0A= function addEntrezLinks(xhtmlData) {=0A= var entrezDiv =3D $("#cb-entrez-links-placeholder");=0A= =0A= if (xhtmlData && (xhtmlData.indexOf('=3D 0)) {=0A= if (entrezDiv.length) {=0A= updateCBItem(entrezDiv, xhtmlData, true);=0A= }=0A= }=0A= else {=0A= if (entrezDiv.length) {=0A= updateCBItem(entrezDiv, '
No NCBI = links
', false);=0A= }=0A= }=0A= }=0A= =0A= function updateSBLinks() {=0A= var fbLink =3D $("a.sb-facebook");=0A= if (fbLink.length) {=0A= fbLink.click(=0A= function(e) {=0A= window.open(this.href, 'sharer', = 'toolbar=3D0,status=3D0,width=3D626,height=3D436');=0A= e.preventDefault();=0A= }=0A= );=0A= }=0A= }=0A= =0A= function addDockedNav() {=0A= var slugEl =3D $("#col-2 #slugline");=0A= // get direct children li elements only=0A= var artViews =3D $("#article-cb-main .cb-section ol:has(li = a[rel^=3D'view-']) > li").clone();=0A= var newDiv =3D '
';=0A= $("#col-2").append(newDiv);=0A= $("#col-2 #docked-nav").hide();=0A= var newDivJQuery =3D $("#docked-nav");=0A= newDivJQuery.append('
This Article
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tags, need to remove to avoid = ugly spaces between words.=0A= =0A= =0A= $("div.ref-list ol.cit-auth-list,div.ref-list ol.cit-ed-list").each(=0A= function(i) {=0A= var original_html =3D $(this).html();=0A= var whitespace_stripped_html;=0A= =0A= //Multiple spaces into one, remove trailing spaces after =
=0A= whitespace_stripped_html =3D original_html.replace(/\s+/g,' = ');=0A= whitespace_stripped_html =3D = whitespace_stripped_html.replace(/<\/li>\s+/gi,'');=0A= whitespace_stripped_html =3D = whitespace_stripped_html.replace(/<\/span>\s+<\/li>/gi,'');=0A= $(this).html(whitespace_stripped_html);=0A= }=0A= );=0A= =0A= }=0A= =0A= function linkPDFExtImg() {=0A= var pdfExtImg =3D $("#content-block div.extract-view = img.pdf-extract-img");=0A= if (pdfExtImg.length) {=0A= pdfExtImg.before(=0A= '
' +=0A= getSiteOption('pdfExtractExpandText','Click image below to view at = full size.') +=0A= '<\/p>'=0A= );=0A= pdfExtImg.wrap('');=0A= var clickA =3D $("#content-block div.extract-view = a.pdf-extract-click");=0A= clickA.click(=0A= function(e) {=0A= var wasExpanded =3D $(this).hasClass("expanded");=0A= if (wasExpanded) {=0A= $(this).removeClass("expanded");=0A= }=0A= else {=0A= $(this).addClass("expanded");=0A= }=0A= $("#content-option-box #content-toggle a").trigger("click");=0A= $("#content-block div.extract-view p.pdf-extract-click-text").text(=0A= =0A= (wasExpanded ? getSiteOption('pdfExtractExpandText','Click image = below to view at full size.') : = getSiteOption('pdfExtractContractText','Click image below to return to = normal size.'))=0A= );=0A= e.preventDefault();=0A= }=0A= );=0A= }=0A= }=0A= function = AuthClickOne(authorAffilDivparam1,authAffilMatch,expandStr,contractStr,e)=0A= {=0A= var allViewMores =3D $(authorAffilDivparam1);=0A= var authAffils =3D $(authAffilMatch);=0A= if ($(authorAffilDivparam1).text() =3D=3D contractStr) {=0A= / hide the affil list /=0A= allViewMores.empty().append(expandStr);=0A= authAffils.each(=0A= function(i) {=0A= modClass(authAffils.eq(i),'hideaffil','showaffil');=0A= }=0A= );=0A= }=0A= else {=0A= allViewMores.empty().append(contractStr);=0A= authAffils.each(=0A= function(i) {=0A= modClass(authAffils.eq(i),'showaffil','hideaffil');=0A= }=0A= );=0A= }=0A= fixColHeights(1);=0A= e.preventDefault();=0A= }=0A= function = AuthClickTwo(authorAffilDivparam2,authAffilMatch,expandStr,contractStr,e)=0A= {=0A= $(authorAffilDivparam1).each(=0A= function() {=0A= if ($(authorAffilDivparam2).text() =3D=3D expandStr) {=0A= $(this).empty().append(contractStr);=0A= var authAffils =3D $(authAffilMatch);=0A= if (authAffils.length) {=0A= authAffils.each(=0A= function(i) {=0A= modClass(authAffils.eq(i),'showaffil','hideaffil');=0A= }=0A= );=0A= }=0A= fixColHeights(1);=0A= }=0A= }=0A= );=0A= }=0A= ------=_NextPart_000_0000_01CB7AB8.6C428120 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jco.ascopubs.org/shared/js/util/hw-col-expand.js var gViewportW =3D 0;=0A= var gDockedBoxLeft =3D 515;=0A= var gDockedBoxNoColsLeft =3D 950;=0A= var gColExpandDocked =3D false;=0A= var gHeaderScrollPos =3D 0;=0A= var gSuppressColExpand =3D false;=0A= =0A= $(document).ready(function() {=0A= if (!(gSuppressColExpand)) {=0A= var isIE6 =3D ($.browser.msie && ($.browser.version.substr(0,2) =3D=3D = '6.'));=0A= =0A= $("div#content-block").prepend('
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';=0A= for (var i=3D3; i>=3D2; i--) {=0A= var col =3D $("div#col-" + i);=0A= if (col.length) {=0A= colDivs =3D colDivs + '
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x
";=0A= if (parentid !=3D null) {=0A= var colstr =3D "div#" + = parentid.substring(0,parentid.indexOf('-min'));=0A= var col =3D $(colstr);=0A= if (col.length) {=0A= //col.prepend(closebox);=0A= var header =3D $("#header");=0A= var headerHeight =3D (header.length ? getObjHeight(header) : = 0);=0A= col.css("top", '' + headerHeight + "px");=0A= modClass(col,"palette","");=0A= col.css("height","auto");=0A= /=0A= $("#col-hover-close a").click(=0A= function(e) {=0A= var ancestors =3D $(this).parents();=0A= modClass(ancestors.eq(1), "", "palette");=0A= $("#col-hover-close").remove();=0A= e.preventDefault();=0A= }=0A= );=0A= /=0A= col.hover(=0A= function() {},=0A= function() {=0A= modClass($(this),"","palette");=0A= //$("#col-hover-close").remove();=0A= $(this).css("top",'');=0A= =0A= }=0A= );=0A= }=0A= }=0A= },=0A= function() {}=0A= );=0A= }=0A= else {=0A= }=0A= }=0A= gColTempResize =3D true;=0A= fixColHeights(-1);=0A= gColTempResize =3D false;=0A= }=0A= }=0A= e.preventDefault();=0A= }=0A= );=0A= =0A= / article navigation docking block /=0A= / this won't work in IE 6, so skip it /=0A= if (!isIE6) {=0A= gViewportW =3D getViewportDim().x;=0A= checkDockedColExpandLoc(true, 2000);=0A= checkColExpandDocking();=0A= $(window).scroll(function() { checkColExpandDocking(); });=0A= }=0A= }=0A= });=0A= =0A= function checkColExpandDocking() {=0A= var header =3D $("#header");=0A= var headerTopOffset =3D (header.length ? header.offset().top : 0);=0A= var headerHeight =3D (header.length ? getObjHeight(header) : 0);=0A= if (headerHeight > 0) {=0A= var offsets =3D getPageOffset();=0A= var headerBottom =3D (headerTopOffset + headerHeight) - offsets.y + 50;=0A= if (gHeaderScrollPos !=3D offsets.y) {=0A= gHeaderScrollPos =3D offsets.y;=0A= if ((headerBottom <=3D 0) && !gColExpandDocked) {=0A= / dock the col expand button /=0A= gColExpandDocked =3D true;=0A= addDockedColExpand();=0A= checkDockedColExpandLoc(true, 0);=0A= }=0A= else if (gColExpandDocked && (headerBottom > 0)) {=0A= / undock the col expand button /=0A= gColExpandDocked =3D false;=0A= removeDockedColExpand();=0A= }=0A= }=0A= }=0A= }=0A= function addDockedColExpand() {=0A= var optionbox =3D $("div#content-option-box");=0A= if (optionbox.length) {=0A= optionbox.hide().addClass('option-box-docked').fadeIn(250);=0A= }=0A= }=0A= function checkDockedColExpandLoc(forceLocate, timerLen) {=0A= if (gColExpandDocked) {=0A= var newViewportW =3D getViewportDim().x;=0A= if (forceLocate || (newViewportW !=3D gViewportW)) {=0A= var dockedExpand =3D $("div#content-option-box");=0A= if (dockedExpand.length) {=0A= var newLeft =3D $("#content-block").offset().left +=0A= (gIsMultiCol ? gDockedBoxLeft : gDockedBoxNoColsLeft);=0A= if ((newViewportW - 50) < newLeft) {=0A= newLeft =3D (newViewportW - 50);=0A= }=0A= dockedExpand.css("left", ('' + newLeft + 'px'));=0A= }=0A= gViewportW =3D newViewportW;=0A= }=0A= }=0A= if (timerLen && (timerLen > 0)) {=0A= checkColExpandDocking();=0A= setTimeout("checkDockedColExpandLoc("+ forceLocate + "," + timerLen + = ")", timerLen);=0A= }=0A= }=0A= =0A= function removeDockedColExpand() {=0A= var optionbox =3D $("div#content-option-box");=0A= if (optionbox.length) {=0A= optionbox.removeClass('option-box-docked');=0A= }=0A= }=0A= ------=_NextPart_000_0000_01CB7AB8.6C428120 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jco.ascopubs.org/shared/js/util/hw-glossaryterm.js / jQuery and other javascript functions /=0A= =0A= $(document).ready(function() {=0A= =0A= var glossaryTermLinks =3D $("a.glossary-term");=0A= if (glossaryTermLinks.length) {=0A= glossaryTermLinks.each(=0A= function(i) {=0A= var href =3D $(this).attr("href");=0A= if (href.length) {=0A= $(this).click(function(e) {=0A= = window.open(href,'glossaryTermWindow','width=3D400,height=3D300,scrollbar= s=3Dyes,resizable=3Dyes');=0A= e.preventDefault();=0A= });=0A= }=0A= }=0A= );=0A= }=0A= =0A= =0A= });=0A= =0A= ------=_NextPart_000_0000_01CB7AB8.6C428120 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jco.ascopubs.org/local/js/hw-local-content.js $(document).ready(function() {=0A= var transPdfs =3D $("#col-2 #article-cb-main = li.full-text-pdf-alt-lang");=0A= if (transPdfs.length) {=0A= var defaultOpen =3D transPdfs.find("span.variant-indicator").length ? = true : false;=0A= var parentOl =3D transPdfs.eq(0).parent("ol");=0A= var listClass =3D "trans-pdfs trans-pdf-" + (defaultOpen ? "open" : = "closed") +"-folder";=0A= parentOl.append('
Translated = PDFs<\/a><\/span>
<\/ul><\/li>');=0A= var transPdfList =3D $("#trans-pdf-list");=0A= for (var i =3D (transPdfs.length - 1); i >=3D 0; i--) {=0A= transPdfList.prepend(transPdfs.eq(i).clone());=0A= transPdfs.eq(i).remove();=0A= }=0A= $("a#trans-pdf-toggle").click(function(e) {=0A= var liparent =3D $(this).parents("li.trans-pdfs");=0A= if (liparent.length) {=0A= liparent =3D liparent.eq(0);=0A= if (liparent.hasClass("trans-pdf-open-folder")) {=0A= modClass(liparent, "trans-pdf-closed-folder", = "trans-pdf-open-folder");=0A= }=0A= else {=0A= modClass(liparent, "trans-pdf-open-folder", = "trans-pdf-closed-folder");=0A= }=0A= }=0A= e.preventDefault();=0A= });=0A= }=0A= });=0A= =0A= function customAddDockBlockCallback(dockId) {=0A= if (dockId =3D=3D 'docked-nav') {=0A= // custom dockblock- do translated pdf folder click handling=0A= $("#docked-nav a#trans-pdf-toggle").click(function(e) {=0A= var liparent =3D $(this).parents("li.trans-pdfs");=0A= if (liparent.length) {=0A= liparent =3D liparent.eq(0);=0A= if (liparent.hasClass("trans-pdf-open-folder")) {=0A= modClass(liparent, "trans-pdf-closed-folder", = "trans-pdf-open-folder");=0A= }=0A= else {=0A= modClass(liparent, "trans-pdf-open-folder", = "trans-pdf-closed-folder");=0A= }=0A= }=0A= e.preventDefault();=0A= });=0A= return false;=0A= }=0A= return true;=0A= }=0A= ------=_NextPart_000_0000_01CB7AB8.6C428120 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://jco.ascopubs.org/local/js/oas_advertising.js var OAS_url =3D 'http://oascentral.jco.ascopubs.org/RealMedia/ads/';=0A= =0A= OAS_listpos =3D 'Top,Right,TopRight';=0A= =0A= OAS_target =3D '_blank';=0A= //end of configuration=0A= var OAS_version =3D 10;=0A= var OAS_rn =3D '001234567890'; OAS_rns =3D '1234567890';=0A= var OAS_rn =3D new String (Math.random()); =0A= OAS_rns =3D OAS_rn.substring (2, 11);=0A= =0A= document.write('');=0A= function OAS_AD(pos) {=0A= if (OAS_version >=3D 11)=0A= OAS_RICH(pos);=0A= else=0A= OAS_NORMAL(pos);=0A= }=0A= =0A= OAS_version =3D 11;=0A= if ((navigator.userAgent.indexOf('Mozilla/3') !=3D -1) || = (navigator.userAgent.indexOf('Mozilla/4.0 WebTV') !=3D -1))=0A= OAS_version =3D 10;=0A= if (OAS_version >=3D 11)=0A= document.write('<\/SCRIPT>');=0A= =0A= function OAS_NORMAL(pos) {=0A= document.write('');=0A= document.write('');=0A= }=0A= ------=_NextPart_000_0000_01CB7AB8.6C428120 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.asco.org/ASCOv2/javascript/site_catalyst_code.js / Version as of 9-27-10 for ASCO - Updated for page tracking by domain, = version H.22 update / / SiteCatalyst code version: H.22. Copyright 1997-2010 Omniture, Inc. More info available at http://www.omniture.com / / ADDITIONAL FEATURES Plugins / var s=3Ds_gi(s_account) / CONFIG SECTION / /* You may add or alter any code config here. / / Conversion Config / s.currencyCode=3D"USD" / Link Tracking Config / s.trackDownloadLinks=3Dtrue s.trackExternalLinks=3Dtrue s.trackInlineStats=3Dtrue s.linkDownloadFileTypes=3D"exe,zip,wav,mp3,mp4,asx,mov,mpg,avi,wmv,pdf,do= c,docx,xls,xlsx,ppt,pptx,pps,xml,cab,prc,jad" s.linkInternalFilters=3Ds_linkInternalFilters; s.linkLeaveQueryString=3Dfalse s.linkTrackVars=3D"None" s.linkTrackEvents=3D"None" / Plugin Config / / Page Name Plugin Config / s.siteID=3D"" // leftmost value in pagename s.defaultPage=3D"" // filename to add when none exists s.queryVarsList=3D"" // query parameters to keep s.pathExcludeDelim=3D";" // portion of the path to exclude s.pathConcatDelim=3D"/" // page name component separator s.pathExcludeList=3D"" // elements to exclude from the path s.usePlugins=3Dtrue function s_doPlugins(s) { var domain =3D document.domain; //make sure domain list exists if ( typeof domainlist !=3D null && typeof domainlist !=3D "undefined" = ) { =09 //loop through domain list for ( var i=3D0 ; i < domainlist.length; i++) { //if domain name matches if ( domain.toLowerCase().indexOf( domainlist[i].domainname ) !=3D = -1 ) { //grab prefix and prefix to pageName s.pageName =3D domainlist[i].prefix + ":" + s.pageName; break; } } } =09 =09 / External Campaigns / if(!s.campaign) s.campaign=3Ds.getQueryParam('cmpid'); =09 / Internal Campaigns / if(!s.eVar4) s.eVar4=3Ds.getQueryParam('intcmp'); =20 /Exact Target Code/ if(!s.eVar20)=20 s.eVar20=3Ds.getQueryParam('et_cid'); =20 s.eVar20=3Ds.getValOnce(s.eVar20,'s_ev20',0);=09 =09 if(!s.eVar21)=20 s.eVar21=3Ds.getQueryParam('et_rid'); =20 s.eVar21=3Ds.getValOnce(s.eVar21,'s_ev21',0); =09 / Site Search / var prevPage=3Ds.getPreviousValue(s.pageName,'gpv_p11'); if(s.prop5){ s.prop5=3Ds.eVar5=3Ds.prop5.toLowerCase(); var t_search=3Ds.getValOnce(s.eVar5,'ev5',0); if(t_search){ s.events=3Ds.apl(s.events,"event5",",",2); 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s.p_fo=3Dnew Function("n","" +"var s=3Dthis;if(!s.fo){s.fo=3Dnew = Object;}if(!s.fo[n]){s.fo[n]=3D" +"new Object;return 1;}else {return 0;}"); / * Plugin: getPageName v2.1 - parse URL and return / s.getPageName=3Dnew Function("u","" +"var = s=3Dthis,v=3Du?u:''+s.wd.location,x=3Dv.indexOf(':'),y=3Dv.indexOf('/'," +"x+4),z=3Dv.indexOf('?'),c=3Ds.pathConcatDelim,e=3Ds.pathExcludeDelim,g=3D= s." +"queryVarsList,d=3Ds.siteID,n=3Dd?d:'',q=3Dz<0?'':v.substring(z+1),p=3Dv= .sub" +"string(y+1,q?z:v.length);z=3Dp.indexOf('#');p=3Dz<0?p:s.fl(p,z);x=3De?p= .i" +"ndexOf(e):-1;p=3Dx<0?p:s.fl(p,x);p+=3D!p||p.charAt(p.length-1)=3D=3D'/'= ?s.d" +"efaultPage:'';y=3Dc?c:'/';while(p){x=3Dp.indexOf('/');x=3Dx<0?p.length:= x;" +"z=3Ds.fl(p,x);if(!s.pt(s.pathExcludeList,',','p_c',z))n+=3Dn?y+z:z;p=3D= p." +"substring(x+1)}y=3Dc?c:'?';while(g){x=3Dg.indexOf(',');x=3Dx<0?g.length= :x" +";z=3Ds.fl(g,x);z=3Ds.pt(q,'&','p_c',z);if(z){n+=3Dn?y+z:z;y=3Dc?c:'&'}g= =3Dg.s" +"ubstring(x+1)}return n"); / * Utility Function: p_c / s.p_c=3Dnew Function("v","c","" +"var x=3Dv.indexOf('=3D');return = c.toLowerCase()=3D=3Dv.substring(0,x<0?v.le" +"ngth:x).toLowerCase()?v:0"); / Configure Modules and Plugins / s.loadModule("Media") s.Media.autoTrack=3Dfalse s.Media.trackWhilePlaying=3Dtrue s.Media.trackVars=3D"None" s.Media.trackEvents=3D"None" / WARNING: Changing any of the below variables will cause drastic changes to how your visitor data is collected. 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s=3Dthis;"+c);return new = s_c(un,pg,ss)}else s=3Dnew Function("un","pg","ss","var s=3Dnew = Object;"+s_ft(c)+";return s");return s(un,pg,ss)} ------=_NextPart_000_0000_01CB7AB8.6C428120--

Cancer Vaccines in Glioma: How to Balance the = Challenges=20 of Small Trials, Efficiency, and Potential Adverse Events

AUTHOR'S DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

Acknowledgment

Footnotes

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