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Cancer Cell,=20 Volume=20 17, Issue 5, 497-509, 18 May 2010 | Copyright = 2010 = Elsevier Inc.=20 All rights = reserved. | 10.1016/j.ccr.2010.03.020

PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural = Stem=20 Cells and Gliomas

Hongwu=20 Zheng, Haoqiang Ying, Ruprecht = Wiedemeyer,=20 Haiyan=20 Yan, Steven N. Quayle, Elena V. = Ivanova, Ji-Hye=20 Paik, Hailei Zhang, Yonghong Xiao, = Samuel R.=20 Perry, Jian Hu, Anant Vinjamoori, = Boyi=20 Gan, Ergun Sahin, Milan G. = Chheda,=20 Cameron=20 Brennan, Y. Alan Wang, William C. = Hahn,=20 Lynda Chin, Ronald A.=20 DePinho 3D"send

= See=20 Affiliations

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= Belfer=20 Institute for Applied Cancer Science, Dana-Farber Cancer Institute, = Boston, MA=20 02115, USA = =20 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA = 02115,=20 USA = =20 Department of Medicine, Harvard Medical School, Boston, MA 02115, = USA= =20 Department of Genetics, Harvard Medical School, Boston, MA 02115, = USA= =20 Department of Dermatology, Brigham and Women's Hospital, Boston, MA = 02115,=20 USA= =20 Department of Neuro-oncology, Massachusetts General Hospital, Boston, MA = 02129,=20 USA = Broad=20 Institute of Harvard and Massachusetts Institute of Technology, = Cambridge, MA=20 02142, USA = =20 Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New = York, NY=20 10065, USA = =20 Department of Neurosurgery, Weill-Cornell Medical College, New York, NY = 10065,=20 USA = =20 Corresponding author = These=20 authors contributed equally to this work

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The identification = of=20 tumor-initiating cells with stem cell-like properties in diverse = cancers,=20 including glioblastoma (GBM), represents an important conceptual advance = with=20 therapeutic implications. There is increasing recognition that = elucidation of=20 the molecular factors governing self-renewal and differentiation of the=20 glioma-initiating cells will advance our understanding of glioma = pathogenesis=20 and biology. Such insightsat the intersection of stem cell and cancer biologymay = provide new=20 points for therapeutic intervention. Here, the identification of = PLAGL2=20 as an amplified gene in human GBM with oncogenic activity and capacity = to=20 regulate Wnt signaling highlights the contribution of differentiation = defect in=20 gliomagenesis and points to differentiation pathways as promising = targets for=20 malignant glioma treatment.

Malignant gliomas, the most = common primary=20 brain tumors in adults, are associated with an extremely high rate of = morbidity=20 and mortality (Furnari=20 et al., 2007). In its most aggressive form, glioblastoma (GBM) = has an=20 average survival of 1 year and characteristic features of diffuse = invasion,=20 intense apoptosis resistance and necrosis, robust angiogenesis, and a = varied=20 so-called multiforme histological profile suggestive of developmental=20 plasticity. It is well known that malignant gliomas are heterogeneous = both in=20 their cell composition and in the relative abundance of cells capable of = propagating tumor cells, albeit the underlying mechanism remains poorly=20 understood (Furnari=20 et al., 2007,Rich=20 and Eyler, 2008,Vescovi=20 et al., 2006). The recent identification of a subpopulation of = tumor=20 cells, designated as glioma stem cell or glioma-initiating cells (GICs), = with=20 strong tumor repopulating potential has illuminated a potential basis = for the=20 intense plasticity and heterogeneous nature of this disease (Bao et al., 2006,Calabrese et al., = 2007,Hemmati = et al., 2003,Lee et al., = 2006,Piccirillo = et al.,=20 2006,Singh = et al.,=20 2004,Son = et al.,=20 2009).

These GICs share certain features = of normal=20 neural stem cells (NSCs) including the expression of neural progenitor = markers,=20 long term self-renewal capacity, and partial multi-lineage = differentiation=20 potential. However, unlike the normal NSCs that follow the developmental = hierarchy and differentiate inevitably into replication-arrested mature = cells=20 (Alvarez-Buylla = et al.,=20 2001,Gage, = 2000,Temple, 2001), = the GICs=20 exhibit anomalous developmental programs that enable escape from = terminal=20 differentiation cues and preserve self-renewal state (Jackson et al., = 2006,Ricci-Vitiani et al., = 2007,Sanai et al., = 2005).=20 Notably, restoration of their differentiation capacities can drastically = reduce=20 GIC tumorigenic potential, supporting the idea that maintenance of an = aberrant=20 differentiation state can contribute to glioma pathogenesis (Jackson et al., = 2006,Lee et al., 2008,Ricci-Vitiani et al., = 2007,Zheng et al., = 2008).

GBM possesses a highly rearranged = genome.=20 High-resolution genome-scale analysis of such has uncovered myriad = somatic=20 alterations on the genomic and epigenetic levels, which presumably = harbor=20 GBM-related oncogenes or tumor suppressors. To identify these = events, we=20 previously had performed high resolution, oligo-based array comparative = genomic=20 hybridization (CGH) profiling of 18 pathologically verified primary GBM=20 specimens and 20 established glioma cell lines (Wiedemeyer et al., = 2008). Using=20 the nonheuristic genome topography scan (GTS) algorithm, we further = identified=20 and ranked the signature genomic events known previously for GBM (e.g., = EGFR=20 amplification or CDKN2A deletion) as well as many previously = uncharacterized=20 alterations based on their amplitude, width, and recurrence of a copy = number=20 alteration (Wiedemeyer=20 et al., 2008). Here we carried an in-depth study on one of the=20 uncharacterized amplified/gained regions that is localized at chromosome = 20q11.21.

GTS analysis of the array CGH = profiles of=20 18 pathologically verified primary GBM specimens and 20 glioma cell = lines=20 identified chromosome 20q11.21 as a region of amplification or gain (Figure 1A; Wiedemeyer et al., = 2008). These=20 profiles delimited a 500 Kb minimal common region of amplification = encompassing=20 seven characterized genes (HCK, TM9SF4, TSPYL3, PLAGL2, POFUT1, ASXL1, and KIF3B), two conserved open = reading=20 frames (ORFs) (c20orf120 and c20orf112), and one=20 pseudogene (RPL24P1) (Figure 1B). Regional amplifications/gains were = further=20 confirmed in the primary tumor (#G328) and cell lines (LN229) by = fluorescence=20 in situ hybridization (FISH) using a probe within the 20q11.21 = amplicon (Figure 1C). Subsequent analysis of = the TCGA data=20 confirmed increased copy number of a broad region at 20q11.21 in 35 of = 238=20 (14.7%) human GBM array CGH profiles (http://tcga-data.nci.nih.gov/tcga/findArchives.htm). = The=20 potential cancer relevance of this region was further suggested by its=20 amplification/gain in approximately 40% of primary colorectal cancer = specimens=20 and cells lines (Figure S1, = available=20 online; Martin = et al.,=20 2007).

To determine the oncogenic = potential of all=20 nine genes residing within this amplicon, we first assessed their = ability to=20 promote anchorage-independent growth. In these studies, we used freshly = isolated=20 primary murine astrocytes doubly null for Ink4a/Arf = and Pten, two signature mutations present in human primary = GBM (Cancer Genomes = Atlas Research=20 Network, 2008,Parsons=20 et al., 2008). Notably, these Ink4a/Arf^/ = Pten^/ astrocytes=20 do not exhibit anchorage-independent growth unless transduced with = additional=20 oncogenes such as the mutant epidermal growth factor receptor EGFRvIII = (data not=20 shown). In this sensitized glioma-relevant background, the above nine ORFs were placed = in the=20 pLenti6-V5-DEST expression vector and introduced individually into the = Ink4a/Arf ^/=20 Pten ^/=20 astrocytes. Of the nine cancer gene candidates, only PLAGL2 induced = colony=20 formation in the semisolid media (Figure 1D).=20 Consistent with PLAGL2 as the target in this amplicon, quantitative = real-time=20 reverse transcriptase PCR (qRT-PCR) revealed that PLAGL2 showed gene = copy=20 number-driven expression in the primary GBM specimen (#G328) with the = 20q11.21=20 amplification (Figure 1E). = Together, these=20 data suggest that PLAGL2 functions as an oncogene that = is=20 targeted for amplification/gain and overexpression in a subset of human = GBM and=20 colorectal cancer cases.

PLAGL2 (pleiomorphic adenoma gene = like 2),=20 a putative C₂H₂ zinc finger=20 transcription factor, was initially identified through structural = homology to=20 its family member PLAG1, a protooncogene frequently rearranged and = overexpressed=20 in pleiomorphic salivary gland adenomas and lipoblastomas (Hensen et al., = 2002,Kas et al., 1997,Kas et al., 1998). = Aberrant=20 PLAGL2 expression has recently been implicated in human acute myeloid = leukemia=20 (Landrette = et al.,=20 2005). However, the biological functions of PLAGL2, including = whether and=20 how it is involved in tumorigenesis, still remain largely unknown. To=20 substantiate the cancer relevance of PLAGL2, we assayed the oncogenic = activity=20 of PLAGL2 in several cell-based systems using both gain- and = loss-of-function=20 strategies. Consistent with the murine Ink4a/Arf^/ = Pten^/ astrocytes=20 findings, enforced PLAGL2 expression also conferred markedly increased=20 anchorage-independent growth of murine p53^/ astrocytes=20 (Figure S2A)=20 and human glioma cell lines including LN215, A172, Hs683, LNZ308, SF767, = and=20 U343 (Figure 2A and Figure S2A). In = addition,=20 we assessed the impact of PLAGL2 on invasive activity, a hallmark = feature of=20 malignant gliomas (Furnari=20 et al., 2007). Using the modified Boyden chamber assay, = enforced PLAGL2=20 expression in both human LN215 cells (Figures 2B=20 and 2C) and primary murine Ink4a/Arf^/ = Pten^/ as well as=20 p53^/ astrocytes (Figures S2B and S2C)=20 significantly enhanced their invasive capacity through matrigel. = Conversely,=20 shRNA-mediated suppression of PLAGL2 reduced anchorage-independent = growth of=20 LN340 and U87 cellstwo glioma lines with 20q11.21 amplification and relatively = high PLAGL2=20 expression levels (Figures 2D and 2E). = Of note,=20 suppressing PLAGL2 expression in the LN319 glioma line lacking 20q11.21=20 amplification and with low PLAGL2 expression failed to impact on=20 anchorage-independent growth (Figure 2F),=20 suggesting that PLAGL2 may serve a tumor maintenance role in those = gliomas with=20 PLAGL2 gene amplification and high expression.

In line with the colorectal = cancer genomic=20 observation, PLAGL2-expressing immortalized rat intestinal epithelial = cells=20 (IEC6) exhibited oncogenic properties of (a) growth in an = anchorage-independent=20 manner (Figure S2D), (b) = anoikis=20 resistance on ultra-low cluster plates (Figure S2E), and = (c)=20 robust tumor growth with metastatic potential within 5 weeks after tail = vein=20 injection. In contrast, IEC6 vector control cells failed to produce = illness=20 within 3 months of observation (Figure S2F). On = the basis=20 of these functional studies, we conclude that PLAGL2 = is a potent=20 oncogene that is targeted for amplification/gain in a subset of = colorectal=20 cancers.

While enforced PLAGL2 expression = in human=20 LN215 glioma cells or primary mouse Ink4a/Arf^/ = Pten^/ astrocytes=20 had a notably minimal impact on cellular proliferation, these cells=20 adopted a rounded, less attached, refractile appearance reminiscent = of=20 stem/progenitor cells (Figure S3).=20 Correspondingly, these PLAGL2-expressing LN215 cells showed increased = expression=20 of the neural stem/progenitor marker Nestin (Figure S3C). = These=20 findings prompted us to speculate that PLAGL2 may exert its oncogenic = impact in=20 part via promoting a stem/progenitor cell-like state. To test this = hypothesis,=20 we first used murine p53^/ NSCs as a=20 model system as it affords a primary cell system and allows for analysis = in the=20 context of p53 mutation, one of the most frequent alterations in human = primary=20 GBM (Cancer = Genomes Atlas=20 Research Network, 2008,Parsons et al., 2008). This p53^/ NSC model=20 system (and confirmatory studies in wild-type as well as Ink4a/Arf^/=20 Pten^/ NSCs) was=20 used to explore PLAGL2-directed cellular and molecular activities = analogous to=20 those of our previous studies (Zheng et al., 2008).

When maintained in the serum-free = NSC=20 proliferation media supplemented with growth factors EGF and bFGF, both = vector=20 control and PlagL2-expressing cells registered roughly the same = NSC/progenitor=20 cell marker patterns such as Nestin expression and showed minimal = differences in=20 proliferation as measured by BrdU incorporation rate (data not shown). = Upon=20 exposure to differentiation media (neural basal media with 1% fetal = bovine=20 serum), as expected, the p53^/ NSC vector=20 control cultures rapidly adopted a flattened cell morphology, = drastically=20 diminished Nestin expression, and reciprocally increased GFAP = (astrocytic=20 marker) or Tuj1 (early neuronal lineage marker) positive staining. In = contrast,=20 PlagL2-expressing p53^/ NSCs=20 retained their stem/progenitor-like morphology and showed feeble = expression of=20 mature lineage markers; 70% of PlagL2-expressing cells retained Nestin=20 expression compared with 5% of control cells (Figures=20 3A and 3B). Additionally, we failed to observe cell-cycle exit that=20 accompanies differentiation in the PlagL2-expressing cells as evidenced = by their=20 robust BrdU incorporation following either a 3 or 24 hr BrdU pulse (3 = hr: 1.6=20 = 1.1% versus=20 15.6 5.0%; 24=20 hr: 1.5 1.6%=20 versus 84.0 =20 6.6%) (Figure 3C, p < = 0.001). Similar=20 results were also observed using wild-type and Ink4a/Arf^/ = Pten^/ mouse NSC=20 cultures (Figures S4A and = S4B).

To confirm further the impaired=20 differentiation phenotype, we used additional differentiation protocols. = We=20 first used the bone morphogenetic protein (BMP)-mediated differentiation = assay,=20 which is known for its function to activate SMAD1/5/8 and elicit = astroglial=20 differentiation of NSC cultures (Lim et al., 2000,Panchision and McKay, 2002). As expected, BMP2 = treatment arrested=20 cell proliferation and stimulated rapid differentiation of the majority = of=20 vector control p53^/ NSCs=20 (77%80%) into=20 GFAP- and S-100-positive astroglial lineage cells (Figures 4A and 4B); in contrast, over 70% of = PlagL2-expressing=20 NSCs retained strong Nestin expression and showed minimal increase of = GFAP- and=20 S-100-positive cells. Accordingly, compared to 4% of vector control = cells, which=20 incorporated BrdU following BMP treatment, 61% of PlagL2-expressing = cells were=20 stained for BrdU (Figure 4C). = Analogous=20 differentiation findings were obtained for p53^/ NSC=20 cultures maintained in neural basal media without growth factors (Figure S4C). In = addition,=20 we confirmed that BMP2 induced strong activation of SMAD1/5/8 components = in both=20 vector control and PlagL2-expressing NSCs (Figure 4D), indicating the impaired = differentiation=20 phenotype is not attributable to suboptimal activation of the BMP = signaling=20 pathway in the PlagL2-expressing NSCs.

Progressive differentiation of = normal=20 stem/progenitor cells is associated with loss of self-renewal capacity, = while=20 cancer cells with high tumorigenic potential typically exhibit strong=20 self-renewal activity with impaired differentiation (Beachy et al., = 2004,Buick et al., 1979,Dick, 2008,Reya et al., 2001,Sanai et al., 2005). = We thus=20 tested whether PlagL2 also affects NSC self-renewal activity as measured = by=20 neurosphere formation. When cultured at low density (100 cells/ml) in = the NSC=20 proliferation medium with EGF and bFGF, the PlagL2-expressing p53^/ NSCs yielded only slightly more multipotent = neurospheres=20 (17.0 3.7% for=20 PLAGL2-expressing NSCs versus 13.8 3.1% for = vector=20 control NSCs; p =3D 0.032) and modestly higher proliferation rates to = those of=20 control p53^/ NSCs (data=20 not shown). Following BMP2 treatment, while less than 1% of vector = control p53^/ NSCs formed neurospheres, PlagL2-expressing p53^/ NSCs readily formed neurospheres (0.65 0.7% = versus 12.8=20 = 4.1%; p <=20 0.001) (Figure 4E). Together, = these data=20 establish that enforced PlagL2 expression impedes NSC differentiation = and=20 preserves their stem cell features such as self-renewal potential and=20 proliferation under differentiation induction.

The impact of PLAGL2 on NSC = renewal and=20 differentiation, coupled with its transforming activity on primary = astrocytes as=20 well as immortalized intestinal epithelial cells, prompted us to assess = whether=20 PLAGL2 influences the stem cell-like properties of human glioma cells. = These=20 stem-like properties are thought to reside in the GIC subpopulation, = which=20 manifest by their self-renewal, partial multi-lineage differentiation=20 capacities, and superior tumorigenic potential in orthotopic models (Bao et al., = 2006,Lee et al., = 2006,Piccirillo = et al.,=20 2006,Singh = et al.,=20 2004,Son = et al.,=20 2009). To assess such properties, we used early passage, = patient-derived=20 GICs that, under serum-free conditions, retain phenotypes and genotypes = more=20 closely mirroring primary tumor profiles as compared to serum-cultured=20 established glioma cell lines that have largely lost their developmental = identities (Galli=20 et al., 2004,Lee=20 et al., 2006,Pollard=20 et al., 2009).

Using the GIC model system, we = observed=20 that PLAGL2-transduced GICs (PLAGL2 GBM-1) versus vector-transduced GICs = (control GBM-1) displayed a 4.3-fold increase (8.11% versus 1.89%) of=20 CD133-positive subpopulation; CD133 is a surface progenitor marker=20 associated with human GICs (Bao et al., 2006,Lee et al., 2006,Piccirillo et al., 2006,Singh et al., 2004) = (Figure 5A and Figure S5A). = Similar=20 results were obtained in two other independently derived GIC lines (Figures S5A and S5B). = When=20 cultured under differentiation-inducing conditions, PLAGL2-expressing = GICs=20 retained robust Nestin expression and substantially higher cell = proliferation=20 relative to the control cells as measured by a 1 hr BrdU incorporation = assay=20 (6.8 2.5%=20 versus 23.7 =20 6.7%; p =3D 0.003) (Figures 5B and 5C). = Moreover, the=20 in vivo tumorigenic assay indicated that the PLAGL2-GICs (GBM-1) = displayed=20 enhanced tumorigenic potential. Compared to the control mice grafted=20 intracranially with 5000 vector control GBM-1 that survived about 4 to 5 = months=20 (Figure 5D), the mice injected = with=20 PLAGL2-GBM-1 often developed diffusively infiltrating gliomas within 2 = to 3=20 months and died at a median of 13.2 weeks. Notably, when examined at = early=20 time points after implantation, unlike vector control GICs that = generated=20 well circumscribed lesions with a clear boundary, the PLAGL2-GIC tumors = were=20 substantially more invasive with diffusively infiltrating tumor cells in = the=20 surrounding brain parenchyma (Figure 5E).=20 These in vivo findings are consistent with the above in vitro = Boyden=20 chamber assay indicating that high PLAGL2 expression promotes glioma = cell=20 invasion. Conversely, shRNA-mediated silencing of endogenous PLAGL2 = expression=20 in a human GIC line (GBM-3) with relatively higher PLAGL2 expression=20 substantially decreased its in vivo tumorigenicity (Figure 5F and Figure S5C). = Together,=20 these findings support the hypothesis that PLAGL2 functions to maintain = stemness=20 of the GICs in the context of differentiation cues and enhances their=20 tumorigenicity and cellular invasion potential.

PLAGL2 is a Zinc finger = transcription=20 factor localized in the nucleus (Kas et al., 1998). In an attempt to elucidate the = molecular=20 mechanisms underlying PlagL2's impact on murine p53^/ NSC and=20 human GIC differentiation, we performed transcriptome comparisons of=20 PlagL2-transduced and vector control p53^/ NSCs=20 following the differentiation induction. As early as 24 hr after = induction,=20 approximately 400 genes exhibited significant differential expression. = Ingenuity=20 pathway analysis of the PlagL2-directed transcriptome identified cell-cycle G1/S=20 checkpoint control as the most enriched canonical pathway (Figure 6A), consistent with the higher = proliferation=20 observed in the PlagL2-expressing NSCs and GICs under differentiation = induction.=20 Notably, the Wnt/=CE=B2-catenin cascade emerged as the second most = enriched canonical=20 pathway. qRT-PCR further confirmed that mRNA transcripts of multiple Wnt = pathway=20 components, including the Wnt6 ligand and Fzd9 and Fzd2 receptors, were=20 substantially upregulated in PlagL2-expressing NSCs (Figure 6B). Consistently, upregulation of Wnt6, = Fzd9, and=20 Fzd2 was also observed in PlagL2-expressing astrocytes as well as the = primary=20 GBM clinical sample (G328) with PLAGL2 amplification (Figures S6A and = S6B).

Wnt/=CE=B2-catenin signaling = plays an important=20 role in maintaining stem cells of various lineages including = NSC/progenitor=20 cells, and aberrant activation of the Wnt/=CE=B2-catenin pathway leads=20 to deregulated growth and cancer (Chenn and Walsh, 2002,Clevers, 2006,Kalani et al., 2008). Thus, our unbiased = genome-scale=20 analysis and confirmatory findings raised the possibility that PlagL2's = function=20 of suppressing NSC/progenitor cell differentiation might be mediated in = part=20 through activation of the Wnt/=CE=B2-catenin pathway. A large body of = previous work=20 has established that the canonical Wnt signaling pathway executes its = actions=20 through the regulated degradation of the transcriptional coactivator = =CE=B2-catenin=20 (Clevers, = 2006,He et al., = 2004,Logan and Nusse, = 2004). In=20 the absence of Wnt stimulation, =CE=B2-catenin is phosphorylated by GSK3 = within the=20 Axin complex and then targeted for rapid degradation by the proteasome = (Aberle et al., = 1997,Amit et al., = 2002,Liu et al., = 2002). On=20 the contrary, stimulation by Wnt inhibits =CE=B2-catenin phosphorylation = and promotes=20 stability.

Consistent with PlagL2-induced = activation=20 of Wnt receptors and ligands in NSC/progenitor cells, immunofluorescence = staining revealed a significantly increased =CE=B2-catenin accumulation = within the=20 PlagL2-NSC/progenitor cells as compared to the vector control cells (Figure 6C). In parallel, = immunohistochemistry=20 analysis detected strong =CE=B2-catenin staining in both malignant = glioma patient=20 samples with PLAGL2 amplification (Figure 6D) and the orthotopic transplants of = PLAGL2-GICs (Figure S6C),=20 reinforcing the role of PLAGL2 on Wnt/=CE=B2-catenin pathway activation. = Moreover,=20 introduction of PlagL2 into murine NSC/progenitor cells and astrocytes = enhanced=20 their TCF-dependent TOPflash reporter activity (Figure 6E and Figure S6D). = Similar=20 results were observed using HEK293T and human glioma LN215 cells (Figures S6E and S6F). = Collectively, these data indicate that PLAGL2 can activate the canonical = Wnt/=CE=B2-catenin signaling cascade.

Numerous studies have documented = the=20 importance of Wnt proteins and its canonical signaling surrogates in the = maintenance of stem cells in different tissues (Adachi et al., 2007,Chenn and Walsh, 2002,Grigoryan et al., = 2008,Nusse, 2008,Pinto and Clevers, 2005,Zechner et al., = 2003). Aberrant=20 activation of Wnt/=CE=B2-catenin signaling tips the homeostatic balance = toward=20 pathological states including malignant transformation. Consistently, we = found=20 that introduction of a stabilized form of =CE=B2-catenin into the mouse = p53/ = NSC/progenitor=20 cells attenuates their differentiation capacity while enhancing = proliferation=20 (Figure S7A).=20 This established paradigm, coupled with the above genomic analysis, = prompted us=20 to test whether PlagL2 acts through the Wnt/=CE=B2-catenin pathway to = maintain the=20 progenitor state of normal and neoplastic stem cells under=20 differentiation-inducing conditions.

We first investigated whether = suppression=20 of Wnt/=CE=B2-catenin signaling through Dickkopf-1 (DKK1) can attenuate = PlagL2's=20 function on NSC/progenitor differentiation. DKK1 is a secreted Wnt = inhibitor,=20 which functions through direct binding to the Wnt coreceptor Lrp5/6 and = thus=20 disrupts Wnt-induced canonical Wnt/=CE=B2-catenin pathway activation (Mao et al., 2001,Semenov et al., = 2001). Since our=20 data indicated that PlagL2 activates Wnt/=CE=B2-catenin cascade on = upstream signaling=20 events through upregulating ligand and receptor expression, one would = predict=20 that introduction of DKK1 should suppress PlagL2-mediated Wnt pathway=20 activation. Indeed, while enforced PlagL2 expression in NSC/progenitor = cells=20 significantly increased the TOPflash reporter activities as compared to = the=20 control cells, further cotransfection with DKK1 largely reversed the = stimulatory=20 effect of PlagL2 on the reporter activity (Figures=20 7A). Moreover, introduction of DKK1 into PlagL2-expressing = NSC/progenitor=20 cells partially restored their differentiation potential as demonstrated = by the=20 decreased progenitor marker (Nestin) staining, increased lineage marker=20 (GFAP/Tuj1) expression, and reduced cell proliferation (Figures 7B and 7C). Similar results were obtained when = shRNAs=20 against Wnt6 or Fzd2 were introduced into PlagL2-expressing = NSC/progenitor cells=20 (Figures 7D and 7E and Figure S7B).

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Cancers arise from disturbances = of critical=20 cellular functions impacting self-renewal, differentiation, survival, = and=20 proliferation (Al-Hajj and=20 Clarke, 2004,Hanahan and=20 Weinberg, 2000,Reya=20 et al., 2001) and such disturbances are often driven by genomic = aberrations in cancer cells. In the current study, integrative genomic = and=20 functional analyses led to the identification and validation of PLAGL2 = as a=20 potent oncoprotein frequently targeted for copy number = gain/amplification in=20 human malignant gliomas and colon cancers. Using both normal and = neoplastic=20 NSC/progenitor cells as model systems, we demonstrated that ectopic = PLAGL2=20 expression greatly enhances NSC/progenitor cell self-renewal and = proliferation=20 upon differentiation induction, suggesting that PLAGL2 executes its = oncogenic=20 activities through regulating the state of cellular differentiation.=20 Additionally, we have provided evidence that this function of PLAGL2 = is at=20 least partially attributable to its capacity to activate = Wnt/=CE=B2-catenin=20 signaling.

It has become increasingly clear = that many=20 cancers are heterogeneous, reminiscent of normal tissue renewal with = stem cells=20 at the apex of this hierarchy. The identification of clonogenic = tumor-initiating=20 cells with stem-like features across many different tumor types has = supported=20 the existence of a cellular hierarchy in tumors (Al-Hajj et al., = 2003,Bonnet and Dick, 1997,Hemmati et al., = 2003,O'Brien et al., = 2007,Ricci-Vitiani et al., = 2007,Singh et al., = 2004,Taylor = et al., 2005).=20 These tumor-initiating cells represent a reservoir of self-sustaining = cells with=20 potent proliferative activity, differentiation resistance, and = tumorigenic=20 potential (Clarke=20 et al., 2006,Dick,=20 2008,Gilbertson and Rich,=20 2007,Reya = et al.,=20 2001). Therefore, a relative arrest in differentiation, such as seen = in the=20 PLAGL2-overexpressing GICs, could contribute to malignant glioma = progression=20 through maintenance and expansion of the GIC pool under conditions that = would=20 otherwise lead to their differentiation. Alternatively, the=20 differentiation-resistant state promoted by elevated PLAGL2 expression = could=20 potentially lead to the accrual of self-renewing glioma cells in which = cell=20 proliferation and differentiation are uncoupled and therefore will allow = a=20 plurality of glioma cells to assume indefinite proliferative capacity as = suggested by the blocked differentiation model of = cancer (Buick et al., = 1979).=20 Support for this view derives from the observations that PLAGL2 = overexpression=20 leads to decreased astroglial differentiation, enhanced renewal in NSCs = under=20 differentiation induction conditions, increased CD133+ subpopulations, = and=20 enhanced GIC tumorigenicity in vivo.

We provide further evidence that = enhanced=20 PLAGL2 expression contributes to the progression of a subset of human = malignant=20 gliomas through regulating their differentiation and renewal. Unlike = normal NSCs=20 that undergo progressive differentiation along a developmental hierarchy = into=20 lineage-restricted progenitors and then their mature progenies (Alvarez-Buylla et al., = 2001,Gage, 2000,Temple, 2001), human = malignant glioma=20 cells generally show minimal terminal differentiation traits and instead = exhibit=20 robust expression of progenitor markers such as Nestin (Tohyama et al., = 1992).=20 Furthermore, the self-renewal capacity of the isolated GICs tends to = correlate=20 with their tumor grade (Singh=20 et al., 2003), supporting the idea that differentiation=20 arrest=20 represents a common feature of malignant glioma progression. Like PLAGL2, some oncogenes can function to interfere with = normal stem=20 cell differentiation, MYC being a notable example, and = such=20 oncogenes also affect glioma cell differentiation (Ben-Porath et al., = 2008,Bruggeman = et al.,=20 2007,Molofsky=20 et al., 2003,Shachaf=20 et al., 2004). However, PLAGL2's function on differentiation = does not=20 appear to use the MYC axis as suggested by the minimal impact of PLAGL2 = on MYC=20 protein expression (data not shown), suggesting that multiple pathways = can be=20 commandeered to sustain self-renewal of GICs in the face of = differentiation=20 cues. Consistent with this notion, the BMP-BMPR signaling system that = controls=20 the activity of normal brain stem cells can function as a key inhibitory = regulator of GICs by regulating their differentiation status (Bao et al., 2006,Calabrese et al., = 2007,Hemmati = et al., 2003,Lee et al., = 2006,Piccirillo = et al.,=20 2006,Singh = et al.,=20 2004,Son = et al.,=20 2009). For example, dysregulated BMP pathway with epigenetically = silenced=20 BMP receptor 1B (BMPR1B) expression has been = demonstrated to=20 contribute to the tumorigenicity of a subset of malignant gliomas = through=20 blocking their GIC differentiation (Lee et al., 2008). Forced BMPR1B expression in = these GICs=20 restored their differentiation potential and substantially decreased = their=20 tumorigenic potential, reinforcing further the view that targeting these = differentiation control pathways may provide novel treatment avenues for = malignant gliomas.

The canonical Wnt cascade is a = critical=20 regulator of stem cell renewal and differentiation in many tissues (Clevers, 2006,Nusse, 2008,Reya and Clevers, 2005). = During normal=20 brain development, Wnt signaling is required for controlling the size of = the=20 self-renewing NSC/progenitor population (Kalani et al., 2008). Moreover, while attenuation = of Wnt=20 signaling causes a reduction in the NSC/progenitor compartment, its = activation through =CE=B2-catenin can increase the cycling and expansion = of neural=20 precursors (Chenn and Walsh,=20 2002,Zechner et al.,=20 2003), raising the possibility that abnormal Wnt pathway activation = may=20 promote NSC/progenitor transformation. Indeed, uncontrolled Wnt pathway=20 activation through mutations in APC (Huang et al., 2000), =CE=B2-catenin (Zurawel et al., = 1998), or axin=20 (Baeza = et al.,=20 2003,Dahmen = et al.,=20 2001) has been found in a subgroup of medulloblastomas, a = pediatric=20 brain tumor in the cerebellum. Although these specific mutations appear = to be=20 rare in gliomas, the level of =CE=B2-catenin expression appears to be = related to the=20 histological grade in a subset of gliomas (Utsuki et al., 2002). = Sustained=20 =CE=B2-catenin activation independent of the mutations has also been = demonstrated in=20 a subset of breast, ovarian, and pancreatic cancers (Bafico et al., 2004,Wang et al., 2009). = In the=20 present study, our findings that PLAGL2 functions to activate = Wnt/=CE=B2-catenin=20 pathway while repression of Wnt activation in PLAGL2-expressing NSCs = sensitize=20 them to differentiation further support Wnt signaling as a key = contributor to=20 the malignant behavior of at least a subset of malignant gliomas.

Overall, these data support a = model in=20 which PLAGL2 functions primarily to affect gliomagenesis via its impact = on=20 differentiation and self-renewal (Figure 8).=20 In the unstimulated NSC/progenitor cells lacking PLAGL2 overexpression, = the Wnt=20 receptor complexes are not bound by ligands, allowing the = axin/APC/GSK3=CE=B2 complex=20 to phosphorylate =CE=B2-catenin and target it for rapid degradation. = When abnormally=20 overexpressed, PLAGL2 activates Wnt ligand and receptor transcription, = resulting=20 in the disruption of the axin/APC/GSK3=CE=B2 complex, =CE=B2-catenin = stabilization, and=20 its subsequent activation. The activated =CE=B2-catenin is then = transferred into the=20 nucleus and activates its downstream effectors, which functionally = contribute to=20 PLAGL2-mediated differentiation arrest and self-renewal maintenance = under=20 differentiation induction. However, it is worth noting that attenuation = of Wnt=20 signaling in PlagL2-expressing NSCs through either DKK1 overexpression = (Figures 7B and 7C) or Wnt6/Fzd2 knockdown = (Figures 7D and 7E) only partially reverses = PlagL2-mediated NSC/progenitor differentiation suppression, suggesting = that the=20 combined actions of PLAGL2 at multiple points in the pathway are needed = for full=20 effort and/or that other differentiation/renewal pathways contribute to=20 regulation of differentiation processes in gliomas.

In summary, aberrant expression = of PLAGL2=20 can function to sustain normal and neoplastic NSC/progenitor cell = renewal and=20 proliferation under differentiation induction conditions, findings = consistent=20 with the prevailing view that differentiation induction restrains tumor = cell=20 self-renewal and tumorigenic potential (Pierce and Speers, 1988). Indeed, the differentiation = therapy has=20 contributed significantly to the management of leukemia (Wang and Chen, 2008). In = this regard,=20 one would predict that a more detailed understanding of the pathways = governing=20 self-renewal and/or differentiation of NSCs and, by extension, GICs = would=20 provide productive entry points for novel drug development efforts in = malignant=20 gliomas and other cancer types.

The human glioma cell lines = LN215, LN229,=20 A172, Hs683, LN319, LN340, LNZ308, SF767, U87, and U343 and the human = embryonic=20 kidney cell line HEK293T were purchased from American Type Culture = Collection.=20 Frozen tumor specimens and human GIC lines were obtained from the = Memorial=20 Sloan-Kettering Cancer Center tumor bank. All tumor specimens were = collected=20 after obtaining written informed consent preoperatively. This study was = approved=20 by the Institutional Review Boards of the Memorial Sloan-Kettering = Cancer Center=20 and Dana-Farber Cancer Institute. The GICs were generated as described=20 previously (Bao = et al.,=20 2006,Lee = et al.,=20 2006,Piccirillo=20 et al., 2006,Singh=20 et al., 2004) without sorting and maintained as tumor spheres = using=20 low-attachment plates in NeuroCult NS-A proliferation media (human; Stem = Cell=20 Technologies) with growth factors. The common genomic and genetic = mutations of=20 the human glioma cell lines and GICs are included in Table S1.

Primary murine p53^/ and Ink4a/Arf^/=20 Pten^/ astrocytes=20 were isolated from 5-day-old pups as previously described (Bachoo et al., 2002) = and=20 maintained in DMEM containing 10% FBS. Primary murine wild-type, p53^/, and Ink4a/Arf^/ = Pten^/ NSCs were=20 isolated from the SVZ regions of 1-month-old mice as previously = described (Rietze and = Reynolds, 2006,Zheng et al., = 2008) and=20 maintained in NeuroCult NS-A proliferation media (mouse; Stem Cell = Technologies)=20 with growth factors. The orthotopic transplantation was performed as = previously=20 described (Zheng et al.,=20 2008). Animals were followed daily for development of neurological = deficits.=20 All mice experiments were performed with the approval of the Harvard and = Dana-Farber Cancer Institute Institutional Animal Care and Use = Committee.

The following antibodies were = used: GFAP=20 (Dako and BD Biosciences), human nestin, mouse nestin (Chemicon), = Tuj-1=20 (Covance), S-100 (Lab Vision), PS-Smad1/5/8, Smad1 (Cell Signaling), = CD133=20 (Miltenyi Biotech), BrdU (Abcam), HA (Covance), =CE=B2-catenin, = =CE=B2-actin (Santa Cruz=20 Biotechnology), and EGFR (Upstate).

Cells were seeded on = polyornithine=20 (Sigma-Aldrich)- and fibronectin (Sigma-Aldrich)-coated coverslips and = cultured=20 within the indicated media. Cells were fixed with 4% paraformaldehyde = and=20 permeabilized with 0.3% Triton X-100 in PBS and blocked with 1% BSA.=20 Subsequently, samples were incubated with indicated primary antibodies = overnight=20 at 4C and=20 corresponding Alexa Fluor-conjugated secondary antibodies (Invitrogen) 1 = hr at=20 room temperature and mounted with mounting medium with DAPI (Vector).=20 Microscopic images were obtained with a Zeiss LSM 510 confocal = microscope in the=20 Harvard NeuroDiscovery Center optical imaging core, using constant = exposure=20 times for each channel in individual experiments.

Cell invasion assays were = performed in=20 duplicate or triplicate in a Boyden chamber of 24 well inserts coated = with=20 matrix proteins as per the manufacturer's protocol (BD Biosciences). = Cells (2=20 = 105) were washed and then seeded in serum-free DMEM = (Invitrogen).=20 The chemoattractant used was DMEM + 10% FBS. After 18 hr incubation and = removal=20 of the noninvading cells, the chambers were stained with 0.5% Crystal = Violet=20 (Sigma-Aldrich) for 20 min and the invading cells were counted.=20 Anchorage-independent growth assays were performed in duplicate or = triplicate in=20 6 well plates. 10⁴ of indicated cells per well = were seeded=20 in DMEM + 10% FBS containing 0.4% low-melting agarose on the top of = bottom agar=20 containing 1% low-melting agarose DMEM + 10% FBS. After 1421 days, = colonies=20 were stained with iodonitrotetrazoliumchloride (Sigma-Aldrich) and = counted.

NSC self-renewal capacity was = measured by=20 plating 100 cells/ml into 6 or 12 well ultra-low cluster plates in NSC=20 proliferation media containing growth factors (EGF 20 ng/ml and bFGF 10 = ng/ml;=20 Sigma-Aldrich) with or without BMP2 (50 ng/ml; R&D Systems). The = number of=20 neurospheres that formed subsequently per well was quantified after 8 = (no BMP2)=20 or 14 days (with BMP2) and relative sphere formation was plotted versus=20 indicated control.

mRNA expression profiling was = performed at=20 the Dana-Farber Microarray Core facility using the Mouse Genome 430 2.0 = Array=20 (Affymetrix). Student's t test was used to identify differentially=20 expressed genes according to expression profiles. The ingenuity pathway = analysis=20 application was performed to identify canonical pathways that were most=20 significant to the functionally related genes according to the = manufacturer's=20 instruction (Ingenuity Systems). In brief, differentially expressed = genes with=20 threshold p =20 0.05 were mapped into Ingenuity Pathways Analysis database as input. = Complete=20 profiles are deposited on the GEO website under super series accession = number=20 GSE21143.

Tumor-free survivals were = analyzed using=20 Graphpad Prism4. Statistical analyses were performed using nonparametric = Mann-Whitney test. Comparisons of cell growth, self-renewal, and = differentiation=20 were performed using the unpaired Student's t test. For all experiments = with=20 error bars, standard deviation was calculated to indicate the variation = within=20 each experiment and data, and values represent mean SEM.

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Jobs from the Cell Career Network

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BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } BODY { PADDING-RIGHT: 495px; PADDING-LEFT: 495px; FONT-SIZE: 90%; = PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #000; PADDING-TOP: 0px; = FONT-FAMILY: arial,helvetica,"Lucida Grande", Tahoma,verdana,sans-serif; = TEXT-ALIGN: left } #sizer { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MAX-WIDTH: 990px; = PADDING-BOTTOM: 0px; WIDTH: 100%; PADDING-TOP: 0px; TEXT-ALIGN: left } #expander { MIN-WIDTH: 856px; MIN-HEIGHT: 1px; BACKGROUND: = url(../../images/right_bg.gif) repeat-y right top; MARGIN: 0px -495px; = POSITION: relative } DIV.info_outline_closed { BACKGROUND: url(../../images/right_bg_narrow.gif) repeat-y right top } #fulltext_body #expander { BACKGROUND: url(../../images/right_bg_ft.gif) repeat-y right top } BODY.home { BACKGROUND: url(../../images/left_bg.gif) repeat-y left top } BODY.toc { BACKGROUND: url(../../images/left_bg.gif) repeat-y left top } BODY.archive { BACKGROUND: url(../../images/left_bg.gif) repeat-y left top } BODY.wide #expander { BACKGROUND: none transparent scroll repeat 0% 0% } * HTML #expander { HEIGHT: 0px } A { COLOR: #000 } P { MARGIN: 0.8em 0px } .alignright { MARGIN: 0px 10px 10px 0px; TEXT-ALIGN: right } .small { FONT-SIZE: 0.8em } .hide { DISPLAY: none } #header { CLEAR: both; MIN-WIDTH: 1000px; MIN-HEIGHT: 8.75em; BACKGROUND: = #005587; WIDTH: 100% } * HTML #header { HEIGHT: 8.75em } #header H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px } #header H1 IMG { MARGIN: 15px 0px 0px 15px } #header_middle { PADDING-LEFT: 245px; PADDING-TOP: 12px } #cover_images { PADDING-RIGHT: 0px; PADDING-LEFT: 80px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #cover_images A { MARGIN-RIGHT: 5px } #cover_images A IMG { BORDER-RIGHT: #fff 2px solid; BORDER-TOP: #fff 2px solid; BORDER-LEFT: = #fff 2px solid; WIDTH: 72px; BORDER-BOTTOM: #fff 2px solid; HEIGHT: 95px } #cover_images A:hover IMG { BORDER-RIGHT: #aaa 2px solid; BORDER-TOP: #aaa 2px solid; BORDER-LEFT: = #aaa 2px solid; BORDER-BOTTOM: #aaa 2px solid } #console { FONT-SIZE: 0.8em; FLOAT: right; WIDTH: 228px; COLOR: #fff; HEIGHT: = 71px; TEXT-ALIGN: center } #console P { PADDING-RIGHT: 8px; PADDING-LEFT: 0px; FONT-SIZE: 0.8em; = PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #005587; PADDING-TOP: 4px; = TEXT-ALIGN: right } #console A { COLOR: #005587 } #console UL { MARGIN: 10px 1em 10px 0px; LIST-STYLE-TYPE: none } #console UL LI { DISPLAY: inline } #console UL LI A { FONT-WEIGHT: bold; FONT-SIZE: 1.1em; MARGIN-LEFT: 1px; COLOR: #fff; = LINE-HEIGHT: 1.2em; MARGIN-RIGHT: 3px; WHITE-SPACE: nowrap; TEXT-ALIGN: = right } #console FORM#searchBox { PADDING-RIGHT: 2px; PADDING-LEFT: 8px; FONT-SIZE: 1.2em; BACKGROUND: = url(../../images/search_bg.gif) #005587 no-repeat left top; FLOAT: = right; PADDING-BOTTOM: 5px; MARGIN: 4px 10px 0px 0px; WIDTH: 208px; = PADDING-TOP: 7px; HEIGHT: 59px; TEXT-ALIGN: left } #console FORM INPUT { BORDER-RIGHT: #6f9ebd 1px solid; BORDER-TOP: #6f9ebd 1px solid; = BORDER-LEFT: #6f9ebd 1px solid; WIDTH: 131px; BORDER-BOTTOM: #6f9ebd 1px = solid } #console FORM INPUT.radio { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: auto! important; BORDER-TOP-STYLE: none! important; = PADDING-TOP: 0px; BORDER-RIGHT-STYLE: none! important; = BORDER-LEFT-STYLE: none! important; BORDER-BOTTOM-STYLE: none! important } .progressIndicator { PADDING-RIGHT: 14px; DISPLAY: none; PADDING-LEFT: 36px; FONT-WEIGHT: = bold; FONT-SIZE: 1em; BACKGROUND: url(../../images/SIR_Loading.gif) = #4b7837 no-repeat 14px 2px; LEFT: 0px; PADDING-BOTTOM: 2px; COLOR: #fff; = PADDING-TOP: 2px; FONT-FAMILY: arial,helvetica,"Lucida Grande", = Tahoma,verdana,sans-serif; POSITION: absolute; TOP: 0px } INPUT.button { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-WEIGHT: bold; FONT-SIZE: 1em; BACKGROUND: #4b7837; = PADDING-BOTTOM: 2px; BORDER-LEFT: 0px; COLOR: #fff; LINE-HEIGHT: 1em; = PADDING-TOP: 2px; BORDER-BOTTOM: 0px; FONT-FAMILY: = arial,helvetica,"Lucida Grande", Tahoma,verdana,sans-serif } A.button { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 0px; FONT-WEIGHT: bold; FONT-SIZE: 1em; BACKGROUND: #4b7837; = PADDING-BOTTOM: 2px; BORDER-LEFT: 0px; COLOR: #fff; LINE-HEIGHT: 1em; = PADDING-TOP: 2px; BORDER-BOTTOM: 0px; FONT-FAMILY: = arial,helvetica,"Lucida Grande", Tahoma,verdana,sans-serif } A.button { PADDING-RIGHT: 37px! important; DISPLAY: block! important; = PADDING-LEFT: 37px! important; FONT-SIZE: 0.96em; PADDING-BOTTOM: 4px! = important; WIDTH: 4em! important; PADDING-TOP: 4px! important; = TEXT-DECORATION: none } A.button:hover { BACKGROUND: #005587 } INPUT.button:hover { BACKGROUND: #005587 } P A.button { MARGIN: 0px auto } P.buttons INPUT.button { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; PADDING-BOTTOM: 2px; = PADDING-TOP: 2px } #console FORM INPUT.button { FONT-SIZE: 0.85em } #console FORM INPUT.button { WIDTH: 55px! important } #console FORM LABEL { FONT-SIZE: 0.9em; MARGIN-LEFT: 4px; COLOR: #125685 } #global_nav { CLEAR: both; BORDER-RIGHT: white 2px; BORDER-TOP: white 2px solid; = MIN-WIDTH: 1000px; BACKGROUND: #e4ddc5 repeat-x; BORDER-LEFT: white 2px = solid; BORDER-BOTTOM: white 2px solid; HEIGHT: 21px } .globalsubtab UL { PADDING-RIGHT: 0px; LIST-STYLE: none none outside; PADDING-LEFT: 0px; = Z-INDEX: 999999; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; = POSITION: relative } #global_nav UL LI { BORDER-RIGHT: white 2px solid; PADDING-RIGHT: 0px; DISPLAY: block; = PADDING-LEFT: 0px; BACKGROUND: url(../../images/globalnav_bg.gif) = #e4ddc5 repeat-x; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px; POSITION: relative } .globalsubtab UL LI { BORDER-RIGHT: white 2px solid; PADDING-RIGHT: 0px; DISPLAY: block; = PADDING-LEFT: 0px; BACKGROUND: url(../../images/globalnav_bg.gif) = #e4ddc5 repeat-x; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-TOP: 0px; POSITION: relative } .globalsubtab UL LI { BORDER-RIGHT-STYLE: none } #global_nav UL LI.expander A { PADDING-RIGHT: 18px; BACKGROUND-POSITION: right 0.5em; = BACKGROUND-IMAGE: url(/images/arrow.png); BACKGROUND-REPEAT: no-repeat; = BACKGROUND-COLOR: #e4ddc5 } #global_nav UL LI A { BORDER-RIGHT: tan 1px solid; PADDING-RIGHT: 7px; BORDER-TOP: tan 1px = solid; DISPLAY: block; PADDING-LEFT: 7px; FONT-WEIGHT: bold; FONT-SIZE: = 0.8em; BACKGROUND: none transparent scroll repeat 0% 0%; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: tan 1px solid; COLOR: = #0f5988; LINE-HEIGHT: 1.68em; PADDING-TOP: 0px; BORDER-BOTTOM: tan 1px = solid; TEXT-DECORATION: none } .globalsubtab UL LI A { BORDER-RIGHT: tan 1px solid; PADDING-RIGHT: 7px; BORDER-TOP: tan 1px = solid; DISPLAY: block; PADDING-LEFT: 7px; FONT-WEIGHT: bold; FONT-SIZE: = 0.8em; BACKGROUND: none transparent scroll repeat 0% 0%; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: tan 1px solid; COLOR: = #0f5988; LINE-HEIGHT: 1.68em; PADDING-TOP: 0px; BORDER-BOTTOM: tan 1px = solid; TEXT-DECORATION: none } .globalsubtab UL LI A { FONT-SIZE: 0.85em } #global_nav UL LI A:hover { BACKGROUND-COLOR: #f7f3e6 } .globalsubtab UL LI A:hover { BACKGROUND-COLOR: #f7f3e6 } .globalsubtab { BORDER-RIGHT: tan 1px solid; PADDING-RIGHT: 4px; BORDER-TOP: tan 1px = solid; DISPLAY: none; PADDING-LEFT: 4px; FONT-SIZE: 0.8em; Z-INDEX: = 20000; BACKGROUND: #d7cfb5; LEFT: 650px; PADDING-BOTTOM: 2px; = BORDER-LEFT: tan 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: tan 1px = solid; POSITION: absolute; TOP: 148px } #global_nav DIV UL LI A { FONT-SIZE: 0.9em; WIDTH: 105px! important; LINE-HEIGHT: 14px; = WHITE-SPACE: nowrap } .globalsubtab UL LI { MARGIN: 0px 1px 1px 0px } #changeJournaljournals { FLOAT: left; WIDTH: 130px } #changeJournaljournals UL LI A { WIDTH: 110px } #changeJournaltrends { FLOAT: left; WIDTH: 165px } #changeJournaltrends UL LI A { WIDTH: 150px } #changeJournaljournals DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 2px; FONT-WEIGHT: bold; FONT-SIZE: = 1em; PADDING-BOTTOM: 0px; COLOR: #555; PADDING-TOP: 1px } #changeJournaltrends DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 2px; FONT-WEIGHT: bold; FONT-SIZE: = 1em; PADDING-BOTTOM: 0px; COLOR: #555; PADDING-TOP: 1px } #forAuthorsSubTab { LEFT: 280px; WIDTH: 140px; TOP: 148px } #forAuthorsSubTab UL LI A { WIDTH: 125px } #journalInfoSubTab { LEFT: 380px; WIDTH: 160px; TOP: 148px } #journalInfoSubTab UL LI A { WIDTH: 145px } #CellPressSubTab { LEFT: 770px; WIDTH: 110px; TOP: 148px } #CellPressSubTab UL LI A { WIDTH: 92px } #changeJournalSubTab { LEFT: 650px; TOP: 148px } #main_banner { CLEAR: both; BACKGROUND: #e7e3c8; HEIGHT: 90px; TEXT-ALIGN: center } #footer_ad { CLEAR: both; BACKGROUND: #e7e3c8; HEIGHT: 90px; TEXT-ALIGN: center } #footer_ad { BORDER-TOP: #fff 10px solid; Z-INDEX: 1; BACKGROUND: #efefef; WIDTH: = 100% } #main_banner IMG { WIDTH: 728px; HEIGHT: 90px } #footer_ad IMG { WIDTH: 728px; HEIGHT: 90px } #footer_ad A { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #footer_ad IMG { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } DIV#main_banner { CLEAR: both; OVERFLOW: hidden } #main_content { PADDING-RIGHT: 376px; PADDING-LEFT: 10px; FONT-SIZE: 0.85em; = PADDING-BOTTOM: 0px; PADDING-TOP: 10px } #main_fulltext_content { PADDING-RIGHT: 376px; PADDING-LEFT: 10px; FONT-SIZE: 0.85em; = PADDING-BOTTOM: 0px; PADDING-TOP: 10px } #main_fulltext_content { =09 } DIV.info_outline_closed #main_content { PADDING-RIGHT: 73px! important } DIV.info_outline_closed #main_fulltext_content { PADDING-RIGHT: 73px! important } #fulltext_body #main_content { PADDING-RIGHT: 218px! important } #fulltext_body #main_fulltext_content { PADDING-RIGHT: 218px! important } #main_content DL { MARGIN: 10px 0px 20px; LIST-STYLE-TYPE: none } #main_content DT { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px } #main_content DD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: 99%; COLOR: #333; PADDING-TOP: 0px } * HTML #main_content DD { WIDTH: auto } #main_content DD A { COLOR: #233b93 } BODY.home #main_content { PADDING-RIGHT: 376px; PADDING-LEFT: 190px; PADDING-BOTTOM: 0px; = PADDING-TOP: 1px } BODY.archive #main_content { PADDING-RIGHT: 376px; PADDING-LEFT: 190px; PADDING-BOTTOM: 0px; = PADDING-TOP: 1px } BODY.outline_open #main_content { PADDING-RIGHT: 376px; PADDING-LEFT: 190px; PADDING-BOTTOM: 0px; = PADDING-TOP: 1px } BODY.outline_open #main_fulltext_content { PADDING-RIGHT: 376px; PADDING-LEFT: 190px; PADDING-BOTTOM: 0px; = PADDING-TOP: 1px } BODY.archive #main_content { PADDING-RIGHT: 376px; PADDING-LEFT: 190px; PADDING-BOTTOM: 0px; = PADDING-TOP: 1px } BODY.toc #main_content { PADDING-RIGHT: 376px; PADDING-LEFT: 190px; PADDING-BOTTOM: 0px; = PADDING-TOP: 1px } BODY.outline_open { BACKGROUND: url(../../images/left_bg.gif) repeat-y left top } BODY.outline_closed { BACKGROUND: url(../../images/left_bg_narrow.gif) repeat-y left top } BODY.outline_closed #main_content { PADDING-RIGHT: 376px; PADDING-LEFT: 73px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } BODY.outline_closed #main_fulltext_content { PADDING-RIGHT: 376px; PADDING-LEFT: 73px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } BODY.outline_closed #left_column { WIDTH: 63px } BODY.wide #main_content { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; = PADDING-TOP: 10px } #fulltext_body #left_column UL { LIST-STYLE-TYPE: none } DIV.article_links { MARGIN-TOP: 3px; FONT-SIZE: 0.8em; MARGIN-BOTTOM: 5px; COLOR: #333; = LINE-HEIGHT: 1.4em } DIV.article_links A { FONT-SIZE: 1.25em; COLOR: #25428e } #footer { CLEAR: both; BORDER-TOP: #fff 10px solid; BACKGROUND: #eae5c8; HEIGHT: = 6em; TEXT-ALIGN: center } #footer UL { LIST-STYLE-TYPE: none } #top_links UL { LIST-STYLE-TYPE: none } #footer_content { MIN-WIDTH: 450px; MARGIN: 1em auto 0px; WIDTH: 30em } #main_content H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 13px; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 8px; PADDING-TOP: 0px } #main_fulltext_content H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 13px; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 8px; PADDING-TOP: 0px } #footer_content H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 13px 0px 0px; WIDTH: 73px; PADDING-TOP: 0px; HEIGHT: = 51px } #footer_content H4 IMG { DISPLAY: block; WIDTH: 73px; HEIGHT: 51px } * HTML #footer_content H4 A IMG { DISPLAY: none } * HTML #footer_content H4 A { DISPLAY: block; Z-INDEX: 1; BACKGROUND-IMAGE: = url(../../images/cell_press.gif); WIDTH: 73px! important; HEIGHT: 51px! = important } #footer_content FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left } #footer_content UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 0.7em; = PADDING-BOTTOM: 0px; MARGIN: 3px 0px 0px; PADDING-TOP: 0px } #footer_content UL LI { FLOAT: left; COLOR: #888885 } #footer_content UL LI A { MARGIN-LEFT: 3px; COLOR: #888885; TEXT-DECORATION: none } #footer_content UL LI A:hover { TEXT-DECORATION: underline } #footer SELECT { VERTICAL-ALIGN: bottom } #footer INPUT.image { MARGIN: 0px; VERTICAL-ALIGN: bottom } #footer INPUT#footer_go { MARGIN: 0px; VERTICAL-ALIGN: bottom } #footer P.copyright { CLEAR: left; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 0.7em; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 3px; COLOR: #888885; = LINE-HEIGHT: 1.2em; PADDING-TOP: 0px } #footer P.copyright A { COLOR: #888885; TEXT-DECORATION: none } #footer P.copyright A:hover { TEXT-DECORATION: underline } #left_column { BORDER-TOP: #fff 10px solid; FONT-SIZE: 0.85em; BACKGROUND: #e9ece3; = FLOAT: left; WIDTH: 180px; PADDING-TOP: 10px } * HTML #left_column { POSITION: relative } #right_column { BORDER-TOP: #fff 10px solid; FONT-SIZE: 0.85em; BACKGROUND: #dee4f0; = FLOAT: right; WIDTH: 356px; PADDING-TOP: 10px } #fulltext_body #right_column { WIDTH: 208px } DIV.info_outline_closed #right_column { WIDTH: 63px! important } #right_column P { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; MARGIN: = 0px; PADDING-TOP: 10px } #main_boombox { PADDING-LEFT: 10px; MARGIN-BOTTOM: 15px; PADDING-TOP: 10px } #floating_login_form { BORDER-RIGHT: #ccc 2px solid; PADDING-RIGHT: 6px; BORDER-TOP: #ccc 2px = solid; PADDING-LEFT: 6px; FONT-SIZE: 0.8em; Z-INDEX: 2009999; RIGHT: = 9999pt; BACKGROUND: #dee4f0; PADDING-BOTTOM: 6px; BORDER-LEFT: #ccc 2px = solid; WIDTH: 21.8em; COLOR: #005587; PADDING-TOP: 12px; BORDER-BOTTOM: = #ccc 2px solid; POSITION: absolute; TOP: 2.6em } #subscribe_main { CLEAR: both; PADDING-RIGHT: 1em; PADDING-LEFT: 1em; BACKGROUND: = #dee4f0; PADDING-BOTTOM: 1em; MARGIN: 2em 0px 1.5em; WIDTH: 660px; = PADDING-TOP: 1em } #floating_login_form LABEL { CLEAR: left; DISPLAY: block; FONT-WEIGHT: bold; FLOAT: left; WIDTH: = 6.5em; LINE-HEIGHT: 1.7em } #floating_login_form INPUT { BORDER-RIGHT: #6f9ebd 1px solid; BORDER-TOP: #6f9ebd 1px solid; = DISPLAY: block; FLOAT: left; MARGIN-BOTTOM: 5px; BORDER-LEFT: #6f9ebd = 1px solid; WIDTH: 9.5em; BORDER-BOTTOM: #6f9ebd 1px solid } #floating_login_form INPUT.hidden { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; MARGIN: 0px; BORDER-RIGHT-WIDTH: 0px } #login_submit { MARGIN: 5px 0px 0px 6.5em } * HTML #login_submit { MARGIN: 5px 0px 0px 3.3em } #forgotlink { CLEAR: both; DISPLAY: block; FONT-SIZE: 11px; MARGIN-LEFT: 6.8em; = COLOR: #005587 } #floating_login_form #rememberme_label { FONT-WEIGHT: normal; FONT-SIZE: 11px; MARGIN: 2px 0px 0px 6.8em; WIDTH: = 120px! important; LINE-HEIGHT: 1.3em } * HTML #floating_login_form #rememberme_label { MARGIN: 2px 0px 0px 3.4em } #welcome { PADDING-RIGHT: 4px; DISPLAY: block; FONT-SIZE: 0.9em; BACKGROUND: = #e4ddc5; FLOAT: right; COLOR: #a0412f; LINE-HEIGHT: 1.68em; POSITION: = relative; TEXT-ALIGN: right } #auto_login { BORDER-TOP-WIDTH: 0px! important; BORDER-LEFT-WIDTH: 0px! important; = BORDER-BOTTOM-WIDTH: 0px! important; BORDER-RIGHT-WIDTH: 0px! important } A#close_login { DISPLAY: block; PADDING-LEFT: 2px; RIGHT: 4px; PADDING-BOTTOM: 2px; = WIDTH: 18px; LINE-HEIGHT: 18px; POSITION: absolute; TOP: 4px; HEIGHT: = 18px; TEXT-ALIGN: center! important; TEXT-DECORATION: none } A#close_login:hover { BACKGROUND: #4b7639; COLOR: #fff } P.alert { PADDING-RIGHT: 13px; MARGIN-TOP: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 0.85em! important; PADDING-BOTTOM: 0.2em! important; COLOR: #f55; = PADDING-TOP: 0px; TEXT-ALIGN: right } .loginError { PADDING-RIGHT: 13px; MARGIN-TOP: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 0.85em! important; PADDING-BOTTOM: 0.2em! important; COLOR: #f55; = PADDING-TOP: 0px; TEXT-ALIGN: right } #floating_login_form DIV.error { PADDING-RIGHT: 13px; MARGIN-TOP: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 0.85em! important; PADDING-BOTTOM: 0.2em! important; COLOR: #f55; = PADDING-TOP: 0px; TEXT-ALIGN: right } #main_content DIV.alert { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #000 = 1px solid; MARGIN-TOP: 1em; PADDING-LEFT: 36px; FONT-SIZE: 1em; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; WIDTH: 26.3em; = LINE-HEIGHT: 16px! important; PADDING-TOP: 10px; BORDER-BOTTOM: #000 1px = solid; TEXT-ALIGN: left! important } #main_content DIV.registerwide { WIDTH: 620px! important } #main_content DIV.alertwide { WIDTH: 57.3em! important } #main_content .registerform DIV.alert { MARGIN-BOTTOM: 1em! important; WIDTH: 57.5%! important } #main_content #main_search DIV.alert { WIDTH: auto! important } #main_content DIV.errormsg { BACKGROUND: url(../../images/msg_icon_error.gif) #efefef no-repeat 5px = 8px } #main_content DIV.alertmsg { BACKGROUND: url(../../images/msg_icon_alert.gif) #efefef no-repeat 5px = 4px } #main_content DIV.infomsg { BACKGROUND: url(../../images/msg_icon_info.gif) #efefef no-repeat 5px = 4px } #main_content DIV.confirmmsg { BACKGROUND: url(../../images/msg_icon_confirm.gif) #efefef no-repeat = 5px 8px } INPUT.checkbox { FLOAT: left! important; WIDTH: auto! important } #main_content H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 1.1em; = PADDING-BOTTOM: 0px; MARGIN: 10px 0px; PADDING-TOP: 0px } #main_fulltext_content H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 1.1em; = PADDING-BOTTOM: 0px; MARGIN: 10px 0px; PADDING-TOP: 0px } #main_content H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 1.3em; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 5px; COLOR: #a0412f; PADDING-TOP: = 0px } #main_fulltext_content H2 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 1.3em; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 5px; COLOR: #a0412f; PADDING-TOP: = 0px } #main_content H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 1.2em; = PADDING-BOTTOM: 0px; MARGIN: 14px 0px 0px; COLOR: #a0412f; PADDING-TOP: = 0px } #main_fulltext_content H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 1.2em; = PADDING-BOTTOM: 0px; MARGIN: 14px 0px 0px; COLOR: #a0412f; PADDING-TOP: = 0px } #main_fulltext_content DIV.alert { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #000 = 1px solid; MARGIN-TOP: 1em; PADDING-LEFT: 36px; FONT-SIZE: 1em; = PADDING-BOTTOM: 10px; BORDER-LEFT: #000 1px solid; WIDTH: 26.3em; = LINE-HEIGHT: 16px! important; PADDING-TOP: 10px; BORDER-BOTTOM: #000 1px = solid; TEXT-ALIGN: left! important } #main_fulltext_content DIV.alertwide { WIDTH: 39.1em! important } #main_fulltext_content DIV.alertmsg { BACKGROUND: url(../../images/msg_icon_alert.gif) #efefef no-repeat 5px = 4px } #main_abstract_content DIV.alert { BORDER-RIGHT: #000 1px solid; PADDING-RIGHT: 0.5em; BORDER-TOP: #000 = 1px solid; MARGIN-TOP: 1em; PADDING-LEFT: 36px; FONT-SIZE: 0.8em; = PADDING-BOTTOM: 10px; MARGIN-LEFT: 0.8em; BORDER-LEFT: #000 1px solid; = WIDTH: 26.3em; LINE-HEIGHT: 16px! important; PADDING-TOP: 10px; = BORDER-BOTTOM: #000 1px solid; TEXT-ALIGN: left! important } #main_abstract_content DIV.alertwide { WIDTH: 39.1em! important } #main_abstract_content DIV.alertmsg { BACKGROUND: url(../../images/msg_icon_alert.gif) #efefef no-repeat 5px = 4px } #left_column H2 { FONT-SIZE: 1.3em! important; MARGIN: 0px; COLOR: #a0412f } #right_column H2 { FONT-SIZE: 1.3em! important; MARGIN: 0px; COLOR: #a0412f } .cover_panel .handle { DISPLAY: block! important; PADDING-LEFT: 21px; BACKGROUND: = url(../../images/cover_panel_top.gif) no-repeat 0px 0px; PADDING-TOP: = 28px } .cover_panel { BACKGROUND: url(../../images/cover_panel_bottom.gif) no-repeat 0px = 100%; MARGIN-BOTTOM: 20px! important; MARGIN-LEFT: 10px } .cover_panel P { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; FONT-SIZE: 0.9em; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-TOP: 0px; TEXT-ALIGN: center } .home_panel { BACKGROUND: url(../../images/left_panel_bottom.gif) no-repeat 0px 100%; = MARGIN-BOTTOM: 20px; MARGIN-LEFT: 10px } .home_panel .handle { PADDING-LEFT: 15px; BACKGROUND: url(../../images/left_panel_top.gif) = no-repeat 0px 0px; MARGIN: 0px; PADDING-TOP: 15px; POSITION: relative } #article_outline H4 { PADDING-LEFT: 15px; BACKGROUND: url(../../images/left_panel_top.gif) = no-repeat 0px 0px; MARGIN: 0px; PADDING-TOP: 15px; POSITION: relative } #archive_outline H4 { PADDING-LEFT: 15px; BACKGROUND: url(../../images/left_panel_top.gif) = no-repeat 0px 0px; MARGIN: 0px; PADDING-TOP: 15px; POSITION: relative } #article_outline H4 { FONT-SIZE: 1.3em } #archive_outline H4 { FONT-SIZE: 1.3em } #article_outline H4 A { FONT-SIZE: 1em; COLOR: #a0412f; TEXT-DECORATION: none } #archive_outline H4 A { FONT-SIZE: 1em; COLOR: #a0412f; TEXT-DECORATION: none } #left_column UL { PADDING-RIGHT: 0px; PADDING-LEFT: 15px; PADDING-BOTTOM: 10px; = PADDING-TOP: 5px; LIST-STYLE-TYPE: none } #left_column UL LI UL { PADDING-BOTTOM: 0px! important } .home_panel UL LI { PADDING-RIGHT: 20px! important; FONT-SIZE: 0.9em; PADDING-BOTTOM: 5px } .home_panel UL LI A { COLOR: #273c99 } .right_panel { FONT-SIZE: 0.8em; BACKGROUND: url(../../images/right_panel_bottom.gif) = no-repeat 0px 100%; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 5px; = MARGIN-LEFT: 10px } #article_options { FONT-SIZE: 0.8em; BACKGROUND: url(../../images/right_panel_bottom.gif) = no-repeat 0px 100%; MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 5px; = MARGIN-LEFT: 10px } .right_panel { FONT-SIZE: 0.9em } #article_options H4 { FONT-SIZE: 1.4em! important; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 2px! = important } #right_column .right_panel .handle { PADDING-LEFT: 15px; BACKGROUND: url(../../images/right_panel_top.gif) = no-repeat 0px 0px; PADDING-TOP: 15px } #article_options H4.handle { PADDING-LEFT: 15px; BACKGROUND: url(../../images/right_panel_top.gif) = no-repeat 0px 0px; PADDING-TOP: 15px } #fulltext_body #right_column .right_panel .handle { BACKGROUND: url(../../images/right_panel_top_ft.gif) no-repeat 0px 0px } #fulltext_body #article_options H4.handle { BACKGROUND: url(../../images/right_panel_top_ft.gif) no-repeat 0px 0px } #fulltext_body .right_panel { BACKGROUND: url(../../images/right_panel_bottom_ft.gif) no-repeat 0px = 100% } BODY#fulltext_body #article_options { BACKGROUND: url(../../images/right_panel_bottom_ft.gif) no-repeat 0px = 100% } #fulltext_body #article_options H4.handle { POSITION: relative } #right_column H3 { PADDING-RIGHT: 0px; PADDING-LEFT: 15px; FONT-SIZE: 1em; PADDING-BOTTOM: = 5px; MARGIN: 0px; PADDING-TOP: 5px } #right_column H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 15px; FONT-SIZE: 1em; PADDING-BOTTOM: = 5px; MARGIN: 0px; PADDING-TOP: 5px } #right_column H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 15px; FONT-SIZE: 1.3em; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #a0412f; PADDING-TOP: 5px } #right_column .right_panel P { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-SIZE: 1em; = PADDING-BOTTOM: 8px; PADDING-TOP: 8px } #right_column UL { LIST-STYLE: none none outside; MARGIN: 5px } #right_column UL LI { PADDING-RIGHT: 15px; PADDING-LEFT: 14px; BACKGROUND: = url(../../images/right_bull.gif) no-repeat left 0.6em } #fulltext_body #right_column UL LI { BACKGROUND: 0px 50% } #right_column UL LI A { DISPLAY: block; FONT-SIZE: 1.1em; LINE-HEIGHT: 1.5em } #right_column DL { MARGIN: 5px 5px 5px 16px; LIST-STYLE-TYPE: none } #right_column DT { PADDING-RIGHT: 15px } #right_column DD { PADDING-RIGHT: 15px } #right_column DT { FONT-WEIGHT: bold } TABLE#search_results { WIDTH: 99% } TABLE#search_results TH { PADDING-LEFT: 18px } TABLE#search_results TD { PADDING-LEFT: 18px } TABLE#search_results TD { PADDING-BOTTOM: 8px; PADDING-TOP: 8px } TABLE#search_results TH { PADDING-RIGHT: 10px; BACKGROUND: #005587; COLOR: #fff; LINE-HEIGHT: = 1.75em; WHITE-SPACE: nowrap } TABLE#search_results TH.last { TEXT-ALIGN: center } TABLE#search_results TD.last { TEXT-ALIGN: center } TABLE#search_results .col-author { WIDTH: 20% } TABLE#search_results .col-title { WIDTH: 40% } TABLE#search_results TD { PADDING-RIGHT: 10px } TABLE#search_results TR.shade1 TD { BACKGROUND: #fff } TABLE#search_results TR.shade2 TD { BACKGROUND: #e9ece5 } TABLE#search_results TR TD A { COLOR: #233b93 } .registerform STRONG { LINE-HEIGHT: 1.8em } .registerform { PADDING-RIGHT: 1em; PADDING-LEFT: 1em; BACKGROUND: #dee4f0; = PADDING-BOTTOM: 1em; MARGIN: 1em 0px 1.5em; WIDTH: 640px; PADDING-TOP: = 1em } .login_box { PADDING-RIGHT: 1em; PADDING-LEFT: 1em; MIN-HEIGHT: 12.8em; BACKGROUND: = #dee4f0; FLOAT: left; PADDING-BOTTOM: 1em; MARGIN: 1em 1.1em 1.5em 0px; = WIDTH: 28em; PADDING-TOP: 1em } * HTML DIV.login_box { HEIGHT: 12.8em } .ind_sub { HEIGHT: 10em! important } .ind_sub P { MARGIN-TOP: 0px; HEIGHT: 5em! important } .ind_sub A.button { DISPLAY: block! important; FLOAT: none; MARGIN: 0px auto; WIDTH: 22em! = important; TEXT-ALIGN: center } #ppvAccess INPUT.button { DISPLAY: block! important; FLOAT: none; MARGIN: 0px auto; WIDTH: 22em! = important; TEXT-ALIGN: center } #main_content #main_supp A.button { DISPLAY: inline; FLOAT: left; WIDTH: 12em! important; MARGIN-RIGHT: = 0.4em! important; TEXT-ALIGN: center } #main_fulltext_content #main_supp A.button { DISPLAY: inline; FLOAT: left; WIDTH: 12em! important; MARGIN-RIGHT: = 0.4em! important; TEXT-ALIGN: center } .login_box H3 { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px 0px 10px; PADDING-TOP: 0px! = important } DIV.login_box LABEL { CLEAR: left! important; PADDING-RIGHT: 0.7em; DISPLAY: block; FLOAT: = left; WIDTH: 8.7em; LINE-HEIGHT: 2em; WHITE-SPACE: nowrap } .login_box FORM { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #pw_username { LINE-HEIGHT: 2em } DIV.login_box LABEL SPAN.note { FONT-SIZE: 0.8em; WIDTH: 8.5em; LINE-HEIGHT: 1em! important; = WHITE-SPACE: normal! important } DIV.login_box INPUT { DISPLAY: block; FLOAT: left; WIDTH: 10em } .registerform INPUT { DISPLAY: block; FLOAT: left; MARGIN-BOTTOM: 2px; WIDTH: 16em } .registerform FIELDSET LABEL { DISPLAY: block; FLOAT: left; WIDTH: 18em } TABLE#email_alerts { PADDING-BOTTOM: 5px; WIDTH: 640px } #email_alerts TD INPUT { CLEAR: none; FLOAT: left; WIDTH: 20px } #email_alerts LABEL { CLEAR: none! important; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal! important; FLOAT: left! important; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: auto! important; PADDING-TOP: 0px } TABLE#email_alerts TH { MARGIN-TOP: 5px; PADDING-BOTTOM: 2px; BORDER-BOTTOM: #102f1b 1px solid } TABLE#email_alerts TD { LINE-HEIGHT: 1.6em; PADDING-TOP: 2px } P.buttons { TEXT-ALIGN: right } P.alerts { WIDTH: 664px } #edit_search { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; FONT-WEIGHT: = bold; RIGHT: 0px; BACKGROUND: #4b7639; PADDING-BOTTOM: 3px; WIDTH: 6em; = COLOR: #fff; PADDING-TOP: 3px; POSITION: absolute; TOP: 0px; TEXT-ALIGN: = center; TEXT-DECORATION: none } #edit_search:hover { TEXT-DECORATION: underline } P#results_no { POSITION: relative } DIV.result-pages { CLEAR: both; BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 4px; = BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 4px; PADDING-BOTTOM: 4px; = MARGIN: 4px 0px; BORDER-LEFT: #ccc 1px solid; PADDING-TOP: 4px; = BORDER-BOTTOM: #ccc 1px solid } DIV.result-pages P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 20%; PADDING-TOP: 0px } DIV.result-pages UL { FLOAT: right; WIDTH: 70%; LIST-STYLE-TYPE: none; TEXT-ALIGN: right } DIV.result-pages UL LI { DISPLAY: inline } DIV.result-pages UL LI A { COLOR: #25428e } .registerform DIV.alert { MARGIN-BOTTOM: 1em! important; WIDTH: 57.5%! important } .registerform SELECT { FLOAT: left; MARGIN: 0.2em 0px; WIDTH: 39% } SELECT#reg_title { MIN-WIDTH: 16em; WIDTH: 20%; MARGIN-RIGHT: 30% } SELECT#titleId { MIN-WIDTH: 16em; WIDTH: 20%; MARGIN-RIGHT: 30% } SELECT.reg_title { MIN-WIDTH: 16em; WIDTH: 20%; MARGIN-RIGHT: 30% } .register_error { CLEAR: both; FONT-WEIGHT: bold; COLOR: #8e0101 } .subscribe_error { CLEAR: both; FONT-WEIGHT: bold; COLOR: #8e0101 } .feedback_error { CLEAR: both; FONT-WEIGHT: bold; COLOR: #8e0101 } FIELDSET { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: = 0px; BORDER-RIGHT-WIDTH: 0px } FIELDSET.reg_comms LABEL { WIDTH: 100%! important; LINE-HEIGHT: 1.6em; WHITE-SPACE: nowrap } * HTML FIELDSET.reg_comms LABEL { LINE-HEIGHT: 2em } FIELDSET.reg_comms LABEL INPUT { MARGIN-RIGHT: 0.6em! important } * HTML FIELDSET.reg_comms LABEL INPUT { MARGIN-RIGHT: 0.2em! important } A.usernameavailable { DISPLAY: block; FONT-SIZE: 0.9em; FLOAT: left; MARGIN-LEFT: 0.4em; = WIDTH: 16em; LINE-HEIGHT: 2.2em } LABEL#loginlabel { COLOR: #dee4f0! important } LABEL#clearlabel { COLOR: #dee4f0! important } #send { MARGIN-LEFT: 9.5em } #_eventId_login { MARGIN-LEFT: 9.5em } * HTML #send { CLEAR: both; MARGIN-LEFT: 4.75em } .registerform LABEL { CLEAR: left; FONT-WEIGHT: bold } A#alerts_fpw { DISPLAY: block! important; PADDING-LEFT: 2.5em; FONT-SIZE: 0.8em! = important; FLOAT: left; PADDING-BOTTOM: 0.8em; WIDTH: 6.7em } SPAN#fpw { CLEAR: both; DISPLAY: block; PADDING-LEFT: 11.7em; FONT-SIZE: 0.8em! = important; LINE-HEIGHT: 1em } .subscribe_button { FLOAT: left; WIDTH: 247px } .subscribe_button .button { MARGIN-BOTTOM: 8px; WIDTH: 190px } FORM#subscribe_online { FLOAT: left; WIDTH: 247px } FORM#renew_online { FLOAT: left; WIDTH: 247px } FORM#activate { FLOAT: left; WIDTH: 247px } FORM#activate { FLOAT: left; PADDING-BOTTOM: 10px; WIDTH: 230px } .subscribe_button { FLOAT: left; WIDTH: 230px } INPUT.ecomm_go { MARGIN-TOP: 2px; MARGIN-LEFT: 4px! important; LINE-HEIGHT: 1em; HEIGHT: = 22px } .registerform INPUT.button { DISPLAY: block; FLOAT: left; MARGIN-BOTTOM: 2px; WIDTH: 9em } FORM#subscribe { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 20px 0px 10px; WIDTH: 750px; PADDING-TOP: 0px } #select_journal UL { MARGIN-TOP: 5px; MARGIN-LEFT: 20px } select_product UL { MARGIN-TOP: 5px; MARGIN-LEFT: 20px } #your_info UL { MARGIN-TOP: 5px; MARGIN-LEFT: 20px } #select_journal LI { FONT-WEIGHT: bold; COLOR: #005587 } #your_info LI { FONT-WEIGHT: bold; COLOR: #005587 } #j_price { DISPLAY: block; FONT-SIZE: 1.2em; FLOAT: left; WIDTH: 20em; COLOR: = #005587; LINE-HEIGHT: 2em } #select_product LABEL { DISPLAY: block } #subscribe_rates TD { PADDING-BOTTOM: 5px } #subscribe_rates TH { PADDING-BOTTOM: 5px } #ecom_trail { PADDING-RIGHT: 1em; BORDER-TOP: #ccc 1px solid; PADDING-LEFT: 1em; = MARGIN-BOTTOM: 10px; PADDING-BOTTOM: 5px; WIDTH: 640px; PADDING-TOP: = 5px; BORDER-BOTTOM: #ccc 1px solid } .ecom_trail_selected { FONT-WEIGHT: bold; FONT-SIZE: 1.1em; FLOAT: left; WIDTH: 200px; COLOR: = #005587; TEXT-ALIGN: center } .ecom_trail_notselected { FONT-WEIGHT: bold; FONT-SIZE: 1.1em; FLOAT: left; WIDTH: 200px; COLOR: = #333; TEXT-ALIGN: center } .ecom_trail_sep { FLOAT: left; WIDTH: 10px; TEXT-ALIGN: center } #ecom_pricebox { CLEAR: both; DISPLAY: block } P#priceContainer { CLEAR: both; PADDING-RIGHT: 0px! important; DISPLAY: block; = PADDING-LEFT: 0px! important; FONT-SIZE: 1.4em; PADDING-BOTTOM: 10px! = important; WIDTH: 557px; COLOR: #005587; PADDING-TOP: 20px! important } P#priceContainer STRONG.label { WIDTH: 24.5%; COLOR: #000; LINE-HEIGHT: 1em } P#priceContainer INPUT { FONT-SIZE: 0.7em; FLOAT: right } #journal_price { DISPLAY: block; FLOAT: left; MARGIN-LEFT: 20px! important } * HTML #journal_price { MARGIN-LEFT: 0px } #add_button { MARGIN-TOP: 30px; DISPLAY: block; FLOAT: right; MARGIN-RIGHT: 31px } #update_button { FLOAT: right; MARGIN-RIGHT: 31px! important } * HTML #add_button { MARGIN-RIGHT: 16px! important } * HTML #update_button { MARGIN-RIGHT: 16px! important } * HTML INPUT.continue { MARGIN-RIGHT: 16px! important } #discountCode { WIDTH: 280px } #pricing_explanations { CLEAR: both; MARGIN: 30px 0px 0px 20px } INPUT.continue { FLOAT: right! important; MARGIN-RIGHT: 31px! important } .form_panel UL { CLEAR: both; PADDING-RIGHT: 15px; DISPLAY: block; PADDING-LEFT: 25px; = BACKGROUND: url(../../images/form_panel_top.gif) no-repeat 0px 0px; = PADDING-BOTTOM: 15px; MARGIN: 0px; PADDING-TOP: 15px; LIST-STYLE-TYPE: = none } .form_panel LI { FONT-WEIGHT: normal! important; MARGIN-BOTTOM: 0.4em; COLOR: #000! = important; LINE-HEIGHT: 1.4em } .form_panel { CLEAR: both; BACKGROUND: url(../../images/form_panel_bottom.gif) = no-repeat 0px 100%; MARGIN: 20px auto 10px; WIDTH: 580px } .form_panel P.first { PADDING-RIGHT: 15px; PADDING-LEFT: 25px; BACKGROUND: = url(../../images/form_panel_top.gif) no-repeat 0px 0px; PADDING-BOTTOM: = 15px; MARGIN: 0px; PADDING-TOP: 15px } .advanced_search LABEL { CLEAR: left; MARGIN-TOP: 0.5em; DISPLAY: block; FONT-WEIGHT: bold; = FLOAT: left; WIDTH: 21.5% } .registerform LABEL { CLEAR: left; MARGIN-TOP: 0.5em; DISPLAY: block; FONT-WEIGHT: bold; = FLOAT: left; WIDTH: 24.5% } .jrnl_main { WIDTH: 160px! important } .advanced_search INPUT { DISPLAY: block; FLOAT: left; MARGIN: 0.2em 0px; WIDTH: 48.5% } .registerform INPUT { DISPLAY: block; FLOAT: left; MARGIN: 0.2em 0px; WIDTH: 48.5% } .registerform STRONG { DISPLAY: block; FLOAT: left; MARGIN: 0.2em 0px; WIDTH: 48.5% } .registerform STRONG { LINE-HEIGHT: 1.8em } .registerform #email_alerts INPUT { WIDTH: auto! important } .advanced_search INPUT.radio { WIDTH: auto! important } .advanced_search INPUT.button { HEIGHT: 1.8em! important } .advanced_search SELECT { CLEAR: right; FLOAT: left; MARGIN: 0.4em 0px } STRONG.toc_pages { COLOR: #6f6f6f } #short_fields { PADDING-LEFT: 21.5%; PADDING-TOP: 1em } #short_fields LABEL { CLEAR: none; PADDING-LEFT: 0px; FLOAT: left; MARGIN-LEFT: 0px; WIDTH: = auto! important; MARGIN-RIGHT: 0.5em; WHITE-SPACE: nowrap } #radio_fields LABEL { CLEAR: none; PADDING-LEFT: 0px; FLOAT: left; MARGIN-LEFT: 0px; WIDTH: = auto! important; MARGIN-RIGHT: 0.5em; WHITE-SPACE: nowrap } #adv_jnrl_holder LABEL { CLEAR: none; PADDING-LEFT: 0px; FLOAT: left; MARGIN-LEFT: 0px; WIDTH: = auto! important; MARGIN-RIGHT: 0.5em; WHITE-SPACE: nowrap } #from_fields LABEL { CLEAR: none; PADDING-LEFT: 0px; FLOAT: left; MARGIN-LEFT: 0px; WIDTH: = auto! important; MARGIN-RIGHT: 0.5em; WHITE-SPACE: nowrap } #from_fields { PADDING-TOP: 0.5em } #from_fields LABEL { DISPLAY: inline! important; FLOAT: left; WIDTH: auto! important; = POSITION: static } #radio_fields LABEL { LINE-HEIGHT: 1.65em! important; MARGIN-RIGHT: 0.5em } LABEL#srch_from { CLEAR: left; PADDING-LEFT: 24.4%; WIDTH: 100px } LABEL#searchYearFrom { CLEAR: left; PADDING-LEFT: 24.4%; WIDTH: 100px } INPUT#srch_pub_all { MARGIN-BOTTOM: 0.5em } #short_fields INPUT { WIDTH: 2.3em! important; MARGIN-RIGHT: 0.8em } #radio_fields INPUT { CLEAR: none; MARGIN-TOP: 0em; VERTICAL-ALIGN: top; WIDTH: auto! = important; LINE-HEIGHT: 1em! important; MARGIN-RIGHT: 0.2em; = PADDING-TOP: 0px } #from_fields INPUT { CLEAR: none! important; DISPLAY: inline! important; FLOAT: none! = important; VERTICAL-ALIGN: middle; WIDTH: auto! important } FIELDSET { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: 0px } FORM.advanced_search { PADDING-RIGHT: 1em; PADDING-LEFT: 1em; BACKGROUND: #dee4f0; = PADDING-BOTTOM: 1em; MARGIN: 1em 0px 1.5em; PADDING-TOP: 1em } * HTML FORM.advanced_search { MARGIN: 0px } .advanced_search { MARGIN-BOTTOM: 1em! important } FORM.advanced_search P { CLEAR: both } LABEL#label_srch_dates { CLEAR: left; DISPLAY: block; WIDTH: 20.5%! important } FIELDSET#radio_fields { PADDING-TOP: 1em } FIELDSET#misc_fields { PADDING-TOP: 1em } INPUT.srch_submit { MARGIN-TOP: 0.2em! important; FLOAT: left; MARGIN-LEFT: 0.5em! = important; WIDTH: 8em! important } INPUT.srch_reset { MARGIN-TOP: 0.2em! important; FLOAT: left; MARGIN-LEFT: 0.5em! = important; WIDTH: 8em! important } INPUT.srch_reset { DISPLAY: block; MARGIN: 0.5em 0px 0px } #search_tips { CLEAR: left; PADDING-RIGHT: 1em; MARGIN-TOP: 0em; PADDING-LEFT: 1em; = BACKGROUND: #e9ece3; MARGIN-BOTTOM: 1em; PADDING-BOTTOM: 1em; WIDTH: = 700px; MARGIN-RIGHT: 20px; PADDING-TOP: 1em } #search_tips H3 { =09 } #search_tips UL { MARGIN: 1em 2em 1em 2.2em } #search_tips UL LI { MARGIN-BOTTOM: 0.5em } DIV.cell_journals { MARGIN-TOP: 3px; FLOAT: left; WIDTH: 290px } DIV.jrnl_main { =09 } DIV.cell_journals INPUT { CLEAR: left; LINE-HEIGHT: 12px! important } DIV.cell_journals LABEL { CLEAR: right; DISPLAY: block; PADDING-LEFT: 7px! important; = FONT-WEIGHT: normal; WIDTH: 140px; LINE-HEIGHT: 12px! important } .error_note { CLEAR: both } #info1 { DISPLAY: none } #info2 { DISPLAY: none } .ecomm_submit_buttons { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 20px; PADDING-TOP: 25px } .reg_note { CLEAR: both! important; DISPLAY: block! important; FONT-SIZE: 0.9em; = MARGIN-LEFT: 20em! important; COLOR: #333 } .basket_price { FONT-WEIGHT: bold } .basket_subtotal { FONT-SIZE: 1.1em } #basket { MARGIN-TOP: 10px } .basket_billing { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; BACKGROUND: #fff; FLOAT: left; = PADDING-BOTTOM: 15px; MARGIN: 15px 15px 15px 0px; WIDTH: 265px; = PADDING-TOP: 0px } .basket_billing H3 { PADDING-RIGHT: 0px; MARGIN-TOP: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } .registerform H3 { CLEAR: both } #promoCode { WIDTH: 243px } P.price { FONT-SIZE: 1.4em; COLOR: #005587 } SPAN.price-note { PADDING-LEFT: 20px; FONT-WEIGHT: normal; FONT-SIZE: 0.65em; COLOR: #333 } INPUT#clearbutton { MARGIN: 0px 4px 0px 9.5em; WIDTH: 7em! important } * HTML INPUT#clearbutton { MARGIN: 0px 0.4em 0px 4.75em } P.note { FONT-WEIGHT: bold; COLOR: #8e0101 } #rss { PADDING-RIGHT: 1em; PADDING-LEFT: 1em; BACKGROUND: #dee4f0; = PADDING-BOTTOM: 1em; WIDTH: 400px; PADDING-TOP: 0.5em } .search_highlighter { BACKGROUND: #ff0 } #main_content TD .search_highlighter { COLOR: #000! important } #main_content H3 .search_highlighter { COLOR: #000! important } #article_options SPAN.search_highlighter { BACKGROUND-COLOR: transparent! important } #article_outline SPAN.search_highlighter { BACKGROUND-COLOR: transparent! important } P.article_doi SPAN.search_highlighter { BACKGROUND-COLOR: transparent! important } P.article_source SPAN.search_highlighter { BACKGROUND-COLOR: transparent! important } #article_options UL LI { MARGIN-BOTTOM: 3px } #left_column UL LI { MARGIN-BOTTOM: 3px } #article_options UL LI { BACKGROUND: none transparent scroll repeat 0% 0% } #article_options UL LI A { BACKGROUND: none transparent scroll repeat 0% 0% } #subscribe_sum { CLEAR: both; MARGIN-TOP: 10px; BACKGROUND: #fff; WIDTH: 582px } #subscribe_sum TD { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 4px; COLOR: #005587; PADDING-TOP: 4px } #subscribe_sum TD A { DISPLAY: block; FONT-SIZE: 0.8em; BACKGROUND: #4b7639; WIDTH: 1.4em; = COLOR: #fff; TEXT-DECORATION: none } #subscribe_sum TD A:hover { BACKGROUND: #005587 } #subscribe_sum TD A { BORDER-TOP-WIDTH: 0px; DISPLAY: block; BORDER-LEFT-WIDTH: 0px; = FONT-SIZE: 0.8em; BACKGROUND: #4b7639; BORDER-BOTTOM-WIDTH: 0px; MARGIN: = 0px auto; WIDTH: 1.4em; COLOR: #fff; BORDER-RIGHT-WIDTH: 0px; = TEXT-DECORATION: none } #subscribe_sum INPUT.submit { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 0.9em; BACKGROUND: #4b7639; FLOAT: = none! important; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: bottom; WIDTH: 20px; COLOR: #fff; PADDING-TOP: 0px; = TEXT-ALIGN: center; BORDER-RIGHT-WIDTH: 0px } #subscribe_sum FORM { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; MARGIN: 0px; PADDING-TOP: 0px! = important; TEXT-ALIGN: center } #subscribe_sum FORM.radioform { TEXT-ALIGN: left! important } #subscribe_sum TH { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-WEIGHT: bold; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px } A#login_fpw { DISPLAY: block! important; PADDING-LEFT: 2.2em; FONT-SIZE: 0.8em! = important; FLOAT: left; WIDTH: 6.7em } #remember_inline_label { CLEAR: none! important; PADDING-LEFT: 0.25em; FONT-SIZE: 0.8em! = important; FLOAT: left! important; PADDING-BOTTOM: 0.4em; WIDTH: 10em } #main_content #select_product .alert { WIDTH: 565px! important } .infobubble { BORDER-RIGHT: #4b7837 2px solid; PADDING-RIGHT: 10px; BORDER-TOP: = #4b7837 2px solid; DISPLAY: none; PADDING-LEFT: 10px; FONT-SIZE: 1.1em; = Z-INDEX: 100000; LEFT: -317px; PADDING-BOTTOM: 10px; BORDER-LEFT: = #4b7837 2px solid; WIDTH: 290px; TEXT-INDENT: -1px; PADDING-TOP: 8px; = BORDER-BOTTOM: #4b7837 2px solid; POSITION: absolute; TOP: 0px; = BACKGROUND-COLOR: #efefef } .infobubble A { DISPLAY: inline! important } .mlktScroll { BORDER-RIGHT: #cccccc 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #cccccc 1px solid; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; OVERFLOW: = auto; BORDER-LEFT: #cccccc 1px solid; WIDTH: 270px; PADDING-TOP: 2px; = BORDER-BOTTOM: #cccccc 1px solid; HEIGHT: 100px; BACKGROUND-COLOR: = #ffffff } .mlktLink { Z-INDEX: 100000; WIDTH: 280px; POSITION: relative } #fulltext_body .mlktLink { WIDTH: 140px } .mlktEmpty { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px; BACKGROUND-COLOR: #ffffff } P.article_type { FONT-WEIGHT: bold; FONT-SIZE: 1.4em; COLOR: #bab5a2 } #article_abstract H2 { COLOR: #1e1c1d } #article_outline { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 0.9em; Z-INDEX: -1; = BACKGROUND: url(../../images/left_panel_bottom.gif) no-repeat 0px 100%; = LEFT: 10px; MARGIN-BOTTOM: 115px; PADDING-BOTTOM: 0px; WIDTH: 160px; = MARGIN-RIGHT: 1%; PADDING-TOP: 0px; POSITION: fixed; TOP: 273px; HEIGHT: = auto } #archive_outline { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 0.9em; BACKGROUND: = url(../../images/left_panel_bottom.gif) no-repeat 0px 100%; = MARGIN-BOTTOM: 25px; PADDING-BOTTOM: 4px; MARGIN-LEFT: 10px; WIDTH: = 160px; MARGIN-RIGHT: 1%; PADDING-TOP: 0px; TOP: 267px; HEIGHT: auto } * HTML #article_outline { HEIGHT: 220px } * HTML #archive_outline { HEIGHT: 220px } * HTML #archive_outline { MARGIN-TOP: 60px! important; HEIGHT: 220px } #article_outline_list { MARGIN: 7px 7px 10px 0px; OVERFLOW: auto; WIDTH: 135px; MAX-HEIGHT: = 160px! important } #article_outline_list_archive { MARGIN: 7px 7px 10px 0px; OVERFLOW: auto; WIDTH: 135px; MAX-HEIGHT: = 160px! important } DIV.outline_closed DIV#article_outline { DISPLAY: none } DIV.info_outline_closed DIV#article_options { DISPLAY: none } #article_options UL { MARGIN-TOP: 0px } DIV.outline_closed DIV#article_outline UL { DISPLAY: none! important } DIV.outline_closed DIV#article_outline H4 { DISPLAY: none! important } #article_outline UL LI A { PADDING-RIGHT: 4px; DISPLAY: block; FONT-SIZE: 1em; LINE-HEIGHT: 1.4em; = TEXT-DECORATION: none } #article_outline UL LI A:hover { TEXT-DECORATION: underline! important } A#open_link { DISPLAY: none; FONT-WEIGHT: bold; BACKGROUND: = url(../../images/outline_open.jpg) no-repeat left top; LEFT: 10px; = WIDTH: 45px; COLOR: #fff; POSITION: fixed; TOP: 267px; HEIGHT: 146px; = TEXT-ALIGN: center; TEXT-DECORATION: none } A#open_link IMG { DISPLAY: none; LEFT: 19px; POSITION: absolute; TOP: 16px } A#open_link:hover IMG { DISPLAY: block! important } A#open_info_link { DISPLAY: none; FONT-WEIGHT: bold; BACKGROUND: = url(../../images/outline_info_open.jpg) no-repeat left top; MARGIN-LEFT: = 10px; WIDTH: 45px; COLOR: #fff; POSITION: relative; HEIGHT: 146px; = TEXT-ALIGN: center; TEXT-DECORATION: none } A#open_info_link IMG { DISPLAY: none; LEFT: 17px; POSITION: absolute; TOP: 119px } A#open_info_link:hover IMG { DISPLAY: block! important } A#close_link { FONT-SIZE: 0.9em; RIGHT: 12px; POSITION: absolute; TOP: 15px } #close_info_link { FONT-SIZE: 0.9em; RIGHT: 30px; COLOR: #a0412f; POSITION: absolute; TOP: = 20px; TEXT-DECORATION: none } A#close_link:hover { COLOR: #4b7837! important } A#close_info_link:hover { COLOR: #4b7837! important } BODY.outline_closed DIV#article_outline { DISPLAY: none } BODY.outline_closed { =09 } BODY.outline_closed DIV#article_outline UL { DISPLAY: none! important } BODY.outline_closed DIV#article_outline H4 { DISPLAY: none! important } * HTML { BACKGROUND-ATTACHMENT: fixed; BACKGROUND-IMAGE: = url(../../images/spacer.gif); BACKGROUND-REPEAT: no-repeat } * HTML #link_holder { DISPLAY: block; LEFT: 10px; POSITION: absolute; TOP: 0px } * HTML DIV#link_holder { =09 } * HTML #article_outline { MARGIN-TOP: 13px; LEFT: 0px; POSITION: absolute; TOP: 0px } * HTML #toc_outline { MARGIN-TOP: 13px; LEFT: 0px; POSITION: absolute; TOP: 0px } * HTML DIV#article_outline { =09 } * HTML DIV#toc_outline { =09 } H2#top_title { COLOR: #1e1c1d } #fulltext_body H3 { TEXT-TRANSFORM: uppercase } #main_content H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #a0412f; PADDING-TOP: 0px } #main_fulltext_content H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #a0412f; PADDING-TOP: 0px } #main_content H4 A.zoom { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #a0412f; PADDING-TOP: 0px } #main_fulltext_content H4 A.zoom { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; COLOR: #a0412f; PADDING-TOP: 0px } A.ja50-ce-cross-ref { TEXT-DECORATION: none } .ja50-figure { BORDER-RIGHT: #005587 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: = #005587 1px solid; PADDING-LEFT: 10px; BACKGROUND: #e6ebf0; = MARGIN-BOTTOM: 1em; PADDING-BOTTOM: 10px; BORDER-LEFT: #005587 1px = solid; PADDING-TOP: 10px; BORDER-BOTTOM: #005587 1px solid } DIV.large-figure { OVERFLOW-X: auto } .figbox { BORDER-RIGHT: #333 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #333 1px = solid; PADDING-LEFT: 10px; BACKGROUND: #efefef; PADDING-BOTTOM: 10px; = BORDER-LEFT: #333 1px solid; PADDING-TOP: 10px; BORDER-BOTTOM: #333 1px = solid } .article_figure TD IMG { BORDER-RIGHT: #005587 1px solid; BORDER-TOP: #005587 1px solid; = BORDER-LEFT: #005587 1px solid; MARGIN-RIGHT: 1em; BORDER-BOTTOM: = #005587 1px solid } .article_figure TD A:hover IMG { BORDER-RIGHT: #333 1px solid; PADDING-RIGHT: 1px; BORDER-TOP: #333 1px = solid; PADDING-LEFT: 1px; PADDING-BOTTOM: 1px; BORDER-LEFT: #333 1px = solid; MARGIN-RIGHT: 1em; PADDING-TOP: 1px; BORDER-BOTTOM: #333 1px = solid } .ja50-ce-label { FONT-WEIGHT: bold; COLOR: #a0412f } .ja50-ce-caption { PADDING-TOP: 1em } .article_figure_versions { MARGIN-TOP: 2em } .article_figure_versions A { COLOR: #a0412f; MARGIN-RIGHT: 2em } #main_content P.sub_buttons A.button { PADDING-RIGHT: 4px! important; PADDING-LEFT: 4px! important; = PADDING-BOTTOM: 4px! important; MARGIN: 0px; WIDTH: 200px! important; = PADDING-TOP: 4px! important; TEXT-ALIGN: center! important } #main_content_popup { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; WIDTH: = 600px; PADDING-TOP: 10px; POSITION: relative } A#close_popup { PADDING-RIGHT: 4px; DISPLAY: block; PADDING-LEFT: 4px; FONT-WEIGHT: = bold; BACKGROUND: #005587; MARGIN-BOTTOM: 1.2em; PADDING-BOTTOM: 4px; = COLOR: #fff; PADDING-TOP: 4px; TEXT-ALIGN: right; TEXT-DECORATION: none } A#close_popup:hover { TEXT-DECORATION: underline } .left_box { HEIGHT: 16em } .right_box { HEIGHT: 16em } #main_supp { MAX-WIDTH: 650px } * HTML #main_supp { WIDTH: 650px } #main_supp DL { PADDING-BOTTOM: 1em; MARGIN: 0px } #main_supp DT { MARGIN-TOP: 1em; FONT-WEIGHT: normal; MARGIN-BOTTOM: 0.3em } #journal_price { DISPLAY: block; FLOAT: left; MARGIN-LEFT: 100px } * HTML #journal_price { MARGIN-LEFT: 80px } P#priceContainer STRONG.label { WIDTH: 24.5%; COLOR: #000; LINE-HEIGHT: 1em } #add_button { MARGIN-TOP: 30px; DISPLAY: block; FLOAT: right; MARGIN-RIGHT: 31px } #update_button { FLOAT: right; MARGIN-RIGHT: 31px! important } * HTML #add_button { MARGIN-RIGHT: 16px! important } * HTML #update_button { MARGIN-RIGHT: 16px! important } * HTML INPUT.continue { MARGIN-RIGHT: 16px! important } #discountCode { WIDTH: 280px } A#rss_link { PADDING-RIGHT: 0px; PADDING-LEFT: 26px; BACKGROUND: = url(../../../images/rss_icon.gif) no-repeat 0px 0px; PADDING-BOTTOM: = 21px; MARGIN: 0px 0px 15px 15px; WIDTH: 100%; LINE-HEIGHT: 45px; = PADDING-TOP: 3px; HEIGHT: 20px; TEXT-DECORATION: none } #main_content H2.advanced A { FONT-SIZE: 0.8em; Z-INDEX: -1; RIGHT: 0px; MARGIN: 0px; COLOR: #005587; = POSITION: absolute; TOP: 5px; TEXT-DECORATION: none } #checkbox_fields { MARGIN-TOP: 8px; MARGIN-BOTTOM: 0.5em } #main_supp H2 { COLOR: #1e1c1d } P.article_supplement { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 1.3em; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 5px; COLOR: #a0412f; = PADDING-TOP: 0px } .article_comment { PADDING-RIGHT: 20px; PADDING-LEFT: 20px; BACKGROUND: #dee4f0; = MARGIN-BOTTOM: 25px; PADDING-BOTTOM: 20px; PADDING-TOP: 10px } A.top { MARGIN-TOP: 10px; DISPLAY: block; FONT-WEIGHT: bold; COLOR: #005587 } #main_supp H3 { CLEAR: both; MARGIN-BOTTOM: 10px } #main_content_popup { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; WIDTH: = 600px; PADDING-TOP: 10px; POSITION: relative } #feedback_popup { MAX-WIDTH: 480px } * HTML #feedback_popup { WIDTH: 480px } .popup_caption { BORDER-RIGHT: #ccc 2px solid; PADDING-RIGHT: 0.3em; BORDER-TOP: #ccc = 2px solid; PADDING-LEFT: 0.3em; PADDING-BOTTOM: 0.3em; BORDER-LEFT: #ccc = 2px solid; PADDING-TOP: 0.3em; BORDER-BOTTOM: #ccc 2px solid } .popup_caption P { MARGIN-TOP: 0px } A#close_popup { PADDING-RIGHT: 4px; DISPLAY: block; PADDING-LEFT: 4px; FONT-WEIGHT: = bold; BACKGROUND: #005587; MARGIN-BOTTOM: 1.2em; PADDING-BOTTOM: 4px; = COLOR: #fff; PADDING-TOP: 4px; TEXT-ALIGN: right; TEXT-DECORATION: none } A#close_popup:hover { TEXT-DECORATION: underline } #main_content_popup .article_figure_versions { MARGIN: 0.75em 0px } BODY.popup #expander { OVERFLOW: hidden; WIDTH: 650px! important } BODY.popup #expander { BACKGROUND: none transparent scroll repeat 0% 0% } BODY.popup #main_content { OVERFLOW: hidden; WIDTH: 650px! important } #adv_jnrl_holder { FLOAT: left; WIDTH: 450px } #purchase_sub { WIDTH: 28em; TEXT-ALIGN: center! important } #expander #purchase_sub INPUT.button { DISPLAY: block! important; MARGIN: 0px 2em; WIDTH: 22em! important; = FONT-FAMILY: arial,verdana, helvetica; TEXT-ALIGN: center } .registerform SELECT.exp { WIDTH: 120px! important; MARGIN-RIGHT: 5px } #registerStatus { HEIGHT: 20px } STRONG.pages { PADDING-LEFT: 1em } H2#leading_edge { COLOR: #a0412f! important } H2#research { COLOR: #02558b! important } #toc_panel UL { MARGIN-TOP: 15px } #toc_panel UL LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #toc_panel UL LI A { DISPLAY: block; FONT-WEIGHT: bold; PADDING-BOTTOM: 10px; COLOR: = #a0412f; TEXT-DECORATION: none } #toc_panel UL LI A:hover { TEXT-DECORATION: underline } #toc_panel H4 { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-WEIGHT: normal; = FONT-SIZE: 1em } .login_box .ecomm_submit_buttons { PADDING-TOP: 10px! important } #add_j_button { WIDTH: 9.2em } P.caption { PADDING-RIGHT: 0px! important; PADDING-LEFT: 0px! important; = PADDING-BOTTOM: 0px! important; 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http://www.cell.com/css/cell/spryTabbedPanels.css .TabbedPanels { CLEAR: none; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0px; WIDTH: 100%; PADDING-TOP: 0px } .TabbedPanelsTabGroup { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .TabbedPanelsTab { BORDER-RIGHT: #999999 1px solid; PADDING-RIGHT: 10px; LIST-STYLE: none = none outside; BORDER-TOP: #999999 1px solid; PADDING-LEFT: 10px; FLOAT: = left; PADDING-BOTTOM: 2px; MARGIN: 0px 1px 0px 0px; FONT: bold 12px = sans-serif; BORDER-LEFT: #cccccc 1px solid; CURSOR: pointer; COLOR: = #005789; PADDING-TOP: 2px; BORDER-BOTTOM: #999999 1px solid; POSITION: = relative; TOP: 1px; HEIGHT: 19px; BACKGROUND-COLOR: #dddddd; = -moz-user-select: none; -x-system-font: none; font-size-adjust: none; = font-stretch: normal } .TabbedPanelsTabHover { BACKGROUND-COLOR: #cccccc } .TabbedPanelsTabSelected { BORDER-BOTTOM: #eeeeee 1px solid; BACKGROUND-COLOR: #eeeeee } .TabbedPanelsTab A { TEXT-DECORATION: none } .TabbedPanelsContentGroup { CLEAR: both; BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px = solid; BORDER-LEFT: #cccccc 1px solid; WIDTH: 410px; BORDER-BOTTOM: = #cccccc 1px solid; HEIGHT: 420px; BACKGROUND-COLOR: #eeeeee } .TabbedPanelsContent { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; PADDING-BOTTOM: 4px; WIDTH: = 402px; PADDING-TOP: 4px; HEIGHT: 402px } .TabbedPanelsContentExtension { PADDING-TOP: 20px; TEXT-ALIGN: center } .TabbedPanelsContentVisible { =09 } .VTabbedPanels .TabbedPanelsTabGroup { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; FLOAT: = left; BORDER-LEFT: #cccccc 1px solid; WIDTH: 10em; BORDER-BOTTOM: = #cccccc 1px solid; POSITION: relative; HEIGHT: 20em; BACKGROUND-COLOR: = #eeeeee } .VTabbedPanels .TabbedPanelsTab { BORDER-RIGHT: medium none; BORDER-TOP: medium none; FLOAT: none; = MARGIN: 0px; BORDER-LEFT: medium none } .VTabbedPanels .TabbedPanelsTabSelected { BORDER-BOTTOM: #999999 1px solid; BACKGROUND-COLOR: #eeeeee } .VTabbedPanels .TabbedPanelsContentGroup { CLEAR: none; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; = PADDING-BOTTOM: 0px; WIDTH: 30em; PADDING-TOP: 0px; HEIGHT: 20em } .graphicala { BACKGROUND-POSITION: 2px 2px; PADDING-LEFT: 24px; BACKGROUND-IMAGE: = url(../../images/Cell/show_image_icon.gif); BACKGROUND-REPEAT: no-repeat } .videoa { BACKGROUND-POSITION: 2px 4px; PADDING-LEFT: 24px; BACKGROUND-IMAGE: = url(../../images/Cell/show_video_icon.gif); BACKGROUND-REPEAT: no-repeat } .audioa { BACKGROUND-POSITION: 2px 4px; PADDING-LEFT: 24px; BACKGROUND-IMAGE: = url(../../images/Cell/show_audio_icon.gif); BACKGROUND-REPEAT: no-repeat } ------=_NextPart_000_0000_01CAFDBC.7EA03CF0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cell.com/css/cell/spryCollapsiblePanel.css .CollapsiblePanel { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #999 0px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; BORDER-LEFT: = #ccc 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #999 1px solid } .CollapsiblePanelTab { PADDING-LEFT: 4px; BACKGROUND-IMAGE: = url(../../images/Cell/colback.jpg); MARGIN: 0px; FONT: bold 11px = sans-serif; CURSOR: pointer; COLOR: #000; PADDING-TOP: 6px; = BACKGROUND-REPEAT: repeat-x; HEIGHT: 20px; -moz-user-select: none; = -khtml-user-select: none } .CollapsiblePanelContent { PADDING-RIGHT: 3px; BACKGROUND-POSITION: 50% bottom; PADDING-LEFT: = 14px; BACKGROUND-IMAGE: url(../../images/Cell/collapsecontentbg.gif); = PADDING-BOTTOM: 3px; MARGIN: 0px; PADDING-TOP: 3px; BACKGROUND-REPEAT: = repeat-x; BACKGROUND-COLOR: #f7f7f7 } .CollapsiblePanelTab A { COLOR: #000; TEXT-DECORATION: none } .CollapsiblePanelOpen .CollapsiblePanelTab { BACKGROUND-COLOR: #eee } .CollapsiblePanelOpen .CollapsiblePanelTab A { BACKGROUND-POSITION: left 50%; PADDING-LEFT: 12px; BACKGROUND-IMAGE: = url(../../images/Cell/minus.gif); COLOR: #000; PADDING-TOP: 1px; = BACKGROUND-REPEAT: no-repeat } .CollapsiblePanelClosed .CollapsiblePanelTab { =09 } .CollapsiblePanelClosed .CollapsiblePanelTab A { BACKGROUND-POSITION: left 50%; PADDING-LEFT: 12px; BACKGROUND-IMAGE: = url(../../images/Cell/plus.gif); COLOR: #000; PADDING-TOP: 1px; = BACKGROUND-REPEAT: no-repeat } .CollapsiblePanelTabHover { BACKGROUND-COLOR: #ccc } .CollapsiblePanelOpen .CollapsiblePanelTabHover { BACKGROUND-COLOR: #ccc } .CollapsiblePanelFocused .CollapsiblePanelTab { BACKGROUND-COLOR: #3399ff } ------=_NextPart_000_0000_01CAFDBC.7EA03CF0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cell.com/css/cell/aotf.css BODY#aotf { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #centercontainer { BACKGROUND: #f1eed9; TEXT-ALIGN: center } #top_ad { PADDING-RIGHT: 8px; PADDING-LEFT: 8px; PADDING-BOTTOM: 8px; OVERFLOW: = hidden; PADDING-TOP: 8px; HEIGHT: 90px } #main_fulltext_content { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: white; = PADDING-BOTTOM: 0px; MARGIN: 0px auto; OVERFLOW: hidden; WIDTH: 978px; = PADDING-TOP: 0px; TEXT-ALIGN: left } #main_fulltext_content_interior { MARGIN: 7px 10px 3px } #main_fulltext_content_blank { =09 } #article_meta { MARGIN: 0px; OVERFLOW: auto } #article_meta H2 { FONT-SIZE: 18px; MARGIN: 0px 0px 2px } #article_source { FONT-SIZE: 11px } P.article_doi { FONT-SIZE: 11px } #article_options { FONT-SIZE: 11px } #article_source { MARGIN-TOP: 0pt; FLOAT: left; PADDING-TOP: 0pt } #article_options { MARGIN-TOP: 0pt; FLOAT: right; PADDING-TOP: 0pt } #article_options IMG { PADDING-RIGHT: 3px; PADDING-LEFT: 6px; PADDING-BOTTOM: 0px; = VERTICAL-ALIGN: middle; PADDING-TOP: 0px } #global_nav UL { =09 } .ajaxcontainer { POSITION: relative } .figajaxcontainer { POSITION: relative } #ajaxanim { BORDER-RIGHT: #808080 2px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #808080 2px solid; DISPLAY: none; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = Z-INDEX: 999999; BACKGROUND: #ededed; LEFT: 400px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #808080 2px solid; WIDTH: 190px; COLOR: #333333; = PADDING-TOP: 0px; BORDER-BOTTOM: #808080 2px solid; POSITION: absolute; = TOP: 50px; TEXT-ALIGN: center } #figajaxanim { BORDER-RIGHT: #808080 2px solid; PADDING-RIGHT: 0px; BORDER-TOP: = #808080 2px solid; DISPLAY: none; PADDING-LEFT: 0px; FONT-WEIGHT: bold; = Z-INDEX: 999999; BACKGROUND: #ededed; LEFT: 400px; PADDING-BOTTOM: 10px; = BORDER-LEFT: #808080 2px solid; WIDTH: 190px; COLOR: #333333; = PADDING-TOP: 0px; BORDER-BOTTOM: #808080 2px solid; POSITION: absolute; = TOP: 50px; TEXT-ALIGN: center } #load { CLEAR: both; PADDING-RIGHT: 0.75em; BORDER-TOP: #005789 2px solid; = DISPLAY: block; PADDING-LEFT: 0.75em; MIN-HEIGHT: 300px; PADDING-BOTTOM: = 0.75em; OVERFLOW: auto; PADDING-TOP: 0.75em; BACKGROUND-COLOR: #ededed; = TEXT-ALIGN: left } .load_textlimit { WIDTH: 700px } .load_textlimit LI { FONT-SIZE: 1.1em; LINE-HEIGHT: 1.6em } P { FONT-SIZE: 1.1em; LINE-HEIGHT: 1.6em } #details_context UL LI { FONT-SIZE: 1.1em; LINE-HEIGHT: 1.6em } DIV#main_banner { BORDER-TOP: #ffffff 10px solid } #main_banner { CLEAR: both; PADDING-RIGHT: 6px; PADDING-LEFT: 6px; BACKGROUND: #e7e3c8 = 0px 0px; PADDING-BOTTOM: 6px; PADDING-TOP: 6px; HEIGHT: 90px; = TEXT-ALIGN: center } #footer_ad { CLEAR: both; PADDING-RIGHT: 6px; PADDING-LEFT: 6px; BACKGROUND: #e7e3c8 = 0px 0px; PADDING-BOTTOM: 6px; PADDING-TOP: 6px; HEIGHT: 90px; = TEXT-ALIGN: center } #authorslist { MARGIN-BOTTOM: 10px; OVERFLOW: hidden; POSITION: relative } A.author { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-WEIGHT: = bold; FLOAT: left; PADDING-BOTTOM: 1px; CURSOR: default; PADDING-TOP: = 1px; WHITE-SPACE: nowrap; TEXT-DECORATION: none } #authorslist SPAN { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 0px; FONT-WEIGHT: = bold; FLOAT: left; PADDING-BOTTOM: 1px; MARGIN: 0px 6px 0px 0px; = PADDING-TOP: 1px; WHITE-SPACE: nowrap; POSITION: relative; = TEXT-DECORATION: none } #authorslist IMG { FLOAT: left; MARGIN: 4px 0px 0px 2px } #open_affil { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; FONT-WEIGHT: bold; FLOAT: left; = PADDING-BOTTOM: 0px; COLOR: #005789; PADDING-TOP: 4px; WHITE-SPACE: = nowrap } #affil_rightpanel { =09 } #affil_rightpanel UL { PADDING-RIGHT: 0px; LIST-STYLE: none none outside; DISPLAY: block; = PADDING-LEFT: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 3px; = HEIGHT: 20px; BACKGROUND-COLOR: #e0e0e0 } #affil_rightpanel UL LI.affil_hint { FONT-WEIGHT: bold; FLOAT: left; COLOR: #333 } #affil_rightpanel UL LI.affil_hide { FLOAT: right } #close_affil { BACKGROUND-POSITION: left 50%; DISPLAY: block; BACKGROUND-IMAGE: = url(../../images/close.gif); WIDTH: 20px; BACKGROUND-REPEAT: no-repeat; = TEXT-DECORATION: none } #close_affil SPAN { WIDTH: 20px; HEIGHT: 20px } #affiliations { CLEAR: both; BORDER-RIGHT: #cccccc 1px solid; PADDING-RIGHT: 0px; = BORDER-TOP: #cccccc 1px solid; DISPLAY: none; PADDING-LEFT: 0px; = Z-INDEX: 10000; BACKGROUND: url(../../images/affiback.gif) #ebeff9 = repeat-x center top; PADDING-BOTTOM: 0px; MARGIN: 0px; OVERFLOW: hidden; = BORDER-LEFT: #cccccc 1px solid; WIDTH: 926px; PADDING-TOP: 0px; = BORDER-BOTTOM: #cccccc 1px solid; POSITION: absolute } #affiliation_scroller { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 4px; OVERFLOW: = auto; PADDING-TOP: 4px; HEIGHT: 250px } #affiliations A.affil { CLEAR: both; PADDING-RIGHT: 1px; DISPLAY: block; PADDING-LEFT: 1px; = FLOAT: left; PADDING-BOTTOM: 1px; WIDTH: 844px; COLOR: black; = PADDING-TOP: 1px; TEXT-DECORATION: none } .hiliter { BACKGROUND-COLOR: #ffff80 } #affiliations A.hiliter { BORDER-RIGHT: #fc0 1px dotted; PADDING-BOTTOM: 0px; COLOR: black; = BORDER-BOTTOM: #fc0 1px dotted; BACKGROUND-COLOR: #ffff80 } #aotftabs { CLEAR: both; MARGIN: 0px } UL.backtabs { CLEAR: both; PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none } .backtabs LI { DISPLAY: inline; LINE-HEIGHT: normal } .backtabs A { PADDING-RIGHT: 0px; PADDING-LEFT: 6px; FONT-SIZE: 1.4em; BACKGROUND: = url(../../images/Cell/tab-left-TL.gif) no-repeat left top; FLOAT: left; = PADDING-BOTTOM: 0px; MARGIN: 0px 2px 0px 0px; PADDING-TOP: 0px; = TEXT-DECORATION: none } .backtabs A SPAN.tabspan { PADDING-RIGHT: 8px; DISPLAY: block; PADDING-LEFT: 0px; FONT-SIZE: 12px; = BACKGROUND: url(../../images/Cell/tab-right-TL.gif) no-repeat right top; = FLOAT: left; PADDING-BOTTOM: 4px; CURSOR: pointer; COLOR: black; = PADDING-TOP: 3px } SPAN.js-kit-comments-count { =09 } .backtabs STRONG SPAN { CURSOR: default } .backtabs A:hover SPAN { BACKGROUND-POSITION: 100% -150px; COLOR: white } .backtabs .active A { BORDER-TOP-WIDTH: 0px; BACKGROUND-POSITION: 0px -150px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: = 0px } .backtabs .active A SPAN { BACKGROUND-POSITION: 100% -150px; PADDING-BOTTOM: 4px; COLOR: white } .backtabs A:hover { BACKGROUND-POSITION: 0% -150px; TEXT-DECORATION: none } DIV.backtabs A:hover SPAN { BACKGROUND-POSITION: 100% -150px } #tabs_container { MARGIN: 0.75em 0px 0px; BORDER-BOTTOM: #005789 2px solid; TEXT-ALIGN: = left } #tabcontent_abstract { DISPLAY: block } #filmstrip { PADDING-RIGHT: 4px; DISPLAY: block; PADDING-LEFT: 4px; BACKGROUND: = url(../../images/stripbg.gif) #455e8d; PADDING-BOTTOM: 4px; WIDTH: = 2200px; PADDING-TOP: 4px; WHITE-SPACE: nowrap; LIST-STYLE-TYPE: none; = HEIGHT: 126px; TEXT-ALIGN: center } #filmstrip LI { CLEAR: none; FLOAT: left } #filmstrip LI A { COLOR: #000000; TEXT-DECORATION: underline } #filmstrip LI A:hover { CURSOR: pointer; TEXT-DECORATION: none } #filmstrip LI A { PADDING-RIGHT: 4px; DISPLAY: block; PADDING-LEFT: 4px; PADDING-BOTTOM: = 4px; PADDING-TOP: 4px; TEXT-DECORATION: none } #filmstrip LI A SPAN { CLEAR: left; DISPLAY: block; TEXT-DECORATION: underline } #filmstrip LI A:hover { BACKGROUND: #999 } #filmstrip LI A:hover SPAN { CLEAR: left; DISPLAY: block; TEXT-DECORATION: none } #filmstrip LI.active { FONT-WEIGHT: bold; BACKGROUND: #bbb; COLOR: black; TEXT-DECORATION: = none! important } .figdetails { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; PADDING-BOTTOM: 0px; WIDTH: = 50%; PADDING-TOP: 0px } .figdetail_imageHolder { WIDTH: 0px; TEXT-ALIGN: center } .detailstoggle { PADDING-RIGHT: 4px; BORDER-TOP: gray 2px solid; PADDING-LEFT: 4px; = FLOAT: left; PADDING-BOTTOM: 4px; WIDTH: 98%; PADDING-TOP: 4px; = POSITION: relative } .intro-reftoggle { PADDING-RIGHT: 4px; BORDER-TOP: gray 2px solid; PADDING-LEFT: 4px; = FLOAT: left; PADDING-BOTTOM: 4px; WIDTH: 98%; PADDING-TOP: 4px; = POSITION: relative } .detailstoggle UL { PADDING-RIGHT: 0px; PADDING-LEFT: 12px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .detailstoggle UL LI { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 3px; = PADDING-TOP: 0px } #bottom_ad { PADDING-RIGHT: 8px; PADDING-LEFT: 8px; PADDING-BOTTOM: 8px; = PADDING-TOP: 8px } #footer_content { CLEAR: both; PADDING-RIGHT: 0px; MIN-WIDTH: 450px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 12px; MARGIN: 0px auto; WIDTH: 30em; PADDING-TOP: 12px } #footer_content UL { LIST-STYLE: none none outside } #footer_content P.copyright { CLEAR: left; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 0.7em; = PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 3px; COLOR: #888885; = LINE-HEIGHT: 1.2em; PADDING-TOP: 0px } #footer_content P A { COLOR: #888885 } #overlay { DISPLAY: none; Z-INDEX: 10000; BACKGROUND: #000; FILTER: = alpha(opacity=3D65); LEFT: 0px; WIDTH: 100%; BOTTOM: 0px; POSITION: = fixed; TOP: 0px; TEXT-ALIGN: center; opacity: 0.65; -moz-opacity: 0.65 } #overlaycontent { BORDER-RIGHT: red 2px solid; BORDER-TOP: red 2px solid; MARGIN: 0px = auto; BORDER-LEFT: red 2px solid; WIDTH: 600px; BORDER-BOTTOM: red 2px = solid; POSITION: relative; TOP: 30px; HEIGHT: 300px } .cornersbasic { BACKGROUND: white; POSITION: relative } .cornersbasic I.ul { DISPLAY: block; BACKGROUND-IMAGE: url(../../images/corners.gif)! = important; OVERFLOW: auto; WIDTH: 7px; BACKGROUND-REPEAT: no-repeat; = POSITION: absolute; HEIGHT: 7px } .cornersbasic I.ur { DISPLAY: block; BACKGROUND-IMAGE: url(../../images/corners.gif)! = important; OVERFLOW: auto; WIDTH: 7px; BACKGROUND-REPEAT: no-repeat; = POSITION: absolute; HEIGHT: 7px } .cornersbasic I.ll { DISPLAY: block; BACKGROUND-IMAGE: url(../../images/corners.gif)! = important; OVERFLOW: auto; WIDTH: 7px; BACKGROUND-REPEAT: no-repeat; = POSITION: absolute; HEIGHT: 7px } .cornersbasic I.lr { DISPLAY: block; BACKGROUND-IMAGE: url(../../images/corners.gif)! = important; OVERFLOW: auto; WIDTH: 7px; BACKGROUND-REPEAT: no-repeat; = POSITION: absolute; HEIGHT: 7px } .cornersbasic I.ur { BACKGROUND-POSITION: -7px 0px; RIGHT: 0px; TOP: 0px } .cornersbasic I.ll { BACKGROUND-POSITION: 0px -7px; LEFT: 0px; BOTTOM: 0px } .cornersbasic I.lr { BACKGROUND-POSITION: -7px -7px; RIGHT: 0px; BOTTOM: 0px } .cornersbasic I.ul { BACKGROUND-POSITION: 0px 0px; LEFT: 0px; TOP: 0px } #ad_bottom_row { PADDING-RIGHT: 0px; PADDING-LEFT: 20px; PADDING-BOTTOM: 12px; MARGIN: = 0px auto; OVERFLOW: hidden; WIDTH: 1000px; PADDING-TOP: 12px; = TEXT-ALIGN: left } #aotf_ads { CLEAR: both; DISPLAY: block; PADDING-BOTTOM: 10px } #careernetwork { PADDING-RIGHT: 12px; PADDING-LEFT: 12px; FLOAT: left; PADDING-BOTTOM: = 6px; WIDTH: 308px; PADDING-TOP: 6px; HEIGHT: 230px } #careernetwork P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 10px } #careernetwork P SPAN { FONT-SIZE: 11px } #flash_ad { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; FLOAT: left; PADDING-BOTTOM: = 6px; WIDTH: 336px; PADDING-TOP: 6px; HEIGHT: 280px } #flash_ad P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 10px } #flash_ad P SPAN { FONT-SIZE: 11px } #ERA_RC { PADDING-RIGHT: 12px; PADDING-LEFT: 12px; FLOAT: left; PADDING-BOTTOM: = 6px; MARGIN-LEFT: 16px; WIDTH: 280px; PADDING-TOP: 6px; HEIGHT: 230px } #relatedLinksHeader { PADDING-RIGHT: 0px; PADDING-LEFT: 14px; FONT-WEIGHT: bold; FONT-SIZE: = 14px; PADDING-BOTTOM: 0px; COLOR: #a0412f; PADDING-TOP: 0px } .eraHeader { DISPLAY: block } .eraeraHeader { DISPLAY: block } .eraRelatedMicrosites DIV { PADDING-RIGHT: 4px; BORDER-TOP: 0px; PADDING-LEFT: 15px; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 2px; MARGIN: 0px; = PADDING-TOP: 4px } .eraMoreRelatedLinks { PADDING-RIGHT: 0px! important; PADDING-LEFT: 16px! important; = FONT-SIZE: 12px! important; PADDING-BOTTOM: 0px! important; PADDING-TOP: = 5px! important } #jobsad { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; FLOAT: left; PADDING-BOTTOM: = 6px; MARGIN-LEFT: 8px; WIDTH: 311px; PADDING-TOP: 6px; HEIGHT: 280px } #jobsad H4 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: = 14px; PADDING-BOTTOM: 6px; MARGIN: 0px; COLOR: #a0412f; PADDING-TOP: 0px } #jobsad P { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 6px; MARGIN: 0px; PADDING-TOP: 0px } 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DISPLAY: block; FLOAT: right; MARGIN-LEFT: 10px; LIST-STYLE-TYPE: none } UL.graphicalSummary { DISPLAY: block; FLOAT: right; MARGIN-LEFT: 10px } LI.summaryHeading { FONT-WEIGHT: bold; PADDING-BOTTOM: 2px; COLOR: #a0412f; = LIST-STYLE-TYPE: none } UL.graphicalAbstract LI.graphicalAbstractImage { WIDTH: 400px; HEIGHT: 400px } UL.summarySection { MARGIN-TOP: 10px; WIDTH: 75% } UL.summarySection LI.summaryText { PADDING-TOP: 2px; LIST-STYLE-TYPE: none } .worddoc { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 1px; BACKGROUND-POSITION: = 2px 50%; BORDER-TOP: #ccc 1px solid; DISPLAY: inline-block; = PADDING-LEFT: 19px; BACKGROUND-IMAGE: url(../../images/docx.ico); = BORDER-LEFT: #ccc 1px solid; CURSOR: pointer; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-REPEAT: no-repeat; WHITE-SPACE: nowrap; = BACKGROUND-COLOR: #e0e0e0; TEXT-DECORATION: none } .spreadsheet { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 1px; BACKGROUND-POSITION: = 2px 50%; BORDER-TOP: #ccc 1px solid; DISPLAY: inline-block; = PADDING-LEFT: 19px; BACKGROUND-IMAGE: url(../../images/xlsx.ico); = BORDER-LEFT: #ccc 1px solid; CURSOR: pointer; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-REPEAT: no-repeat; WHITE-SPACE: nowrap; = BACKGROUND-COLOR: #e0e0e0; TEXT-DECORATION: none } .presentation { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 1px; BACKGROUND-POSITION: = 2px 50%; BORDER-TOP: #ccc 1px solid; DISPLAY: inline-block; = PADDING-LEFT: 19px; BACKGROUND-IMAGE: url(../../images/pptx.ico); = BORDER-LEFT: #ccc 1px solid; CURSOR: pointer; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-REPEAT: no-repeat; WHITE-SPACE: nowrap; = BACKGROUND-COLOR: #e0e0e0; TEXT-DECORATION: none } .pdfdoc { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 1px; BACKGROUND-POSITION: = 2px 50%; BORDER-TOP: #ccc 1px solid; DISPLAY: inline-block; = PADDING-LEFT: 19px; BACKGROUND-IMAGE: url(../../images/pdft.gif); = BORDER-LEFT: #ccc 1px solid; CURSOR: pointer; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-REPEAT: no-repeat; WHITE-SPACE: nowrap; = BACKGROUND-COLOR: #e0e0e0; TEXT-DECORATION: none } .textdocument { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 1px; BACKGROUND-POSITION: = 2px 50%; BORDER-TOP: #ccc 1px solid; DISPLAY: inline-block; = PADDING-LEFT: 19px; BACKGROUND-IMAGE: url(../../images/notepad.gif); = BORDER-LEFT: #ccc 1px solid; CURSOR: pointer; BORDER-BOTTOM: #999 1px = solid; BACKGROUND-REPEAT: no-repeat; WHITE-SPACE: nowrap; = BACKGROUND-COLOR: #e0e0e0; TEXT-DECORATION: none } .zipfiles { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 1px; BACKGROUND-POSITION: = 2px 50%; BORDER-TOP: #ccc 1px solid; DISPLAY: inline-block; = PADDING-LEFT: 19px; BACKGROUND-IMAGE: = url(../../images/zip-file-icon.gif); BORDER-LEFT: #ccc 1px solid; = CURSOR: pointer; BORDER-BOTTOM: #999 1px solid; BACKGROUND-REPEAT: = no-repeat; WHITE-SPACE: nowrap; BACKGROUND-COLOR: #e0e0e0; = TEXT-DECORATION: none } .videofiles { BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 1px; BACKGROUND-POSITION: = 2px 50%; BORDER-TOP: #ccc 1px solid; DISPLAY: inline-block; = PADDING-LEFT: 30px; BACKGROUND-IMAGE: = url(../../images/video-file-icon.gif); BORDER-LEFT: #ccc 1px solid; = CURSOR: pointer; BORDER-BOTTOM: #999 1px solid; BACKGROUND-REPEAT: = no-repeat; WHITE-SPACE: nowrap; BACKGROUND-COLOR: #e0e0e0; = TEXT-DECORATION: none } .flashvideo { PADDING-RIGHT: 1px; BACKGROUND-POSITION: 2px top; PADDING-LEFT: 19px; = BACKGROUND-IMAGE: url(../../images/flashvideo.gif); CURSOR: pointer; = BACKGROUND-REPEAT: no-repeat } .documentInfo { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #666 1px solid; DISPLAY: = none; FONT-SIZE: 11px; Z-INDEX: 99999; LEFT: 0px; BORDER-LEFT: #666 1px = solid; WIDTH: 300px; BORDER-BOTTOM: #999 1px solid; POSITION: absolute; = TOP: 0px; BACKGROUND-COLOR: #e0e0e0 } .documentInfo UL { OVERFLOW: auto; MAX-HEIGHT: 250px; LIST-STYLE-TYPE: none } .documentInfo SPAN.worddocBig { BACKGROUND-POSITION: 2px 50%; DISPLAY: block; PADDING-BOTTOM: 2px; = WIDTH: 100%; PADDING-TOP: 2px; BORDER-BOTTOM: #577cc2 1px solid; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; BACKGROUND-COLOR: #b8c9e5 } .documentInfo SPAN.spreadsheetBig { BACKGROUND-POSITION: 2px 50%; DISPLAY: block; PADDING-BOTTOM: 2px; = WIDTH: 100%; PADDING-TOP: 2px; BORDER-BOTTOM: #577cc2 1px solid; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; BACKGROUND-COLOR: #8fc668 } .documentInfo SPAN.presentationBig { BACKGROUND-POSITION: 2px 50%; DISPLAY: block; PADDING-BOTTOM: 2px; = WIDTH: 100%; PADDING-TOP: 2px; BORDER-BOTTOM: #e52800 1px solid; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; BACKGROUND-COLOR: #ff8b62 } .documentInfo SPAN.pdfdocBig { BACKGROUND-POSITION: 2px 50%; DISPLAY: block; PADDING-BOTTOM: 2px; = WIDTH: 100%; COLOR: #fff; PADDING-TOP: 2px; BORDER-BOTTOM: #660101 1px = solid; BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; BACKGROUND-COLOR: = #dc0d0d } .documentInfo SPAN.pdfdocBig A { COLOR: #fff } .documentInfo SPAN.textdocumentBig { BACKGROUND-POSITION: 2px 50%; DISPLAY: block; PADDING-BOTTOM: 2px; = WIDTH: 100%; PADDING-TOP: 2px; BORDER-BOTTOM: #34b2b4 1px solid; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; BACKGROUND-COLOR: #64e2e4 } .documentInfo SPAN.zipfilesBig { BACKGROUND-POSITION: 2px 50%; DISPLAY: block; PADDING-BOTTOM: 2px; = WIDTH: 100%; PADDING-TOP: 2px; BORDER-BOTTOM: #cc9e04 1px solid; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; BACKGROUND-COLOR: #fcce34 } .documentInfo SPAN.videofilesBig A { COLOR: #fff } .documentInfo SPAN.videofilesBig { BACKGROUND-POSITION: 2px 50%; DISPLAY: block; PADDING-BOTTOM: 2px; = WIDTH: 100%; COLOR: #fff; PADDING-TOP: 2px; BORDER-BOTTOM: #660101 1px = solid; BACKGROUND-REPEAT: no-repeat; HEIGHT: 16px; BACKGROUND-COLOR: = #1c2a54 } .documentInfo SPAN UL LI.datatype { PADDING-LEFT: 18px; FONT-WEIGHT: bold; FLOAT: left; MARGIN: 0px; = BACKGROUND-COLOR: transparent } .documentInfo SPAN UL LI.downloadlink A { PADDING-RIGHT: 2px; BACKGROUND-POSITION: 3px 50%; PADDING-LEFT: 18px; = FLOAT: left; BACKGROUND-IMAGE: url(../../images/download.jpg); MARGIN: = 0px; BACKGROUND-REPEAT: no-repeat; BACKGROUND-COLOR: transparent } .documentInfo UL LI.title { CLEAR: left; PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; = PADDING-TOP: 3px } .documentInfo UL LI.description { CLEAR: left; PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-TOP: 3px } #expproc-overview-div A.tip { COLOR: #005789; TEXT-DECORATION: none } #figuresTabContent A.tip { COLOR: #005789; TEXT-DECORATION: none } #expproc-overview-div A.tip:hover { TEXT-DECORATION: underline } #figuresTabContent A.tip:hover { TEXT-DECORATION: underline } #expproc-detailed-div A.tip { COLOR: #005789; TEXT-DECORATION: none } #figuresTabContent A.tip { COLOR: #005789; TEXT-DECORATION: none } #expproc-detailed-div A.tip:hover { TEXT-DECORATION: underline } #figuresTabContent A.tip:hover { TEXT-DECORATION: underline } .TabbedPanelsOutline { PADDING-BOTTOM: 2px; LIST-STYLE-TYPE: none } .graphicalAbstractImageSpan { BACKGROUND-POSITION: 1px 1px; DISPLAY: block; WIDTH: 400px; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 400px; TEXT-ALIGN: center } .mmcDownloadLink { CLEAR: both; BACKGROUND-POSITION: left 50%; DISPLAY: block; = PADDING-LEFT: 15px; FONT-WEIGHT: normal; FONT-SIZE: 10px; = BACKGROUND-IMAGE: url(../../images/Cell/download.jpg); COLOR: #900; = PADDING-TOP: 6px; BACKGROUND-REPEAT: no-repeat; WHITE-SPACE: nowrap; = HEIGHT: 25px; TEXT-ALIGN: left } .mmcDownloadAnchor { DISPLAY: block; PADDING-TOP: 6px } .mmcDownloadSpan { BACKGROUND-POSITION: left center; PADDING-LEFT: 15px; FONT-WEIGHT: = normal; FONT-SIZE: 10px; BACKGROUND-IMAGE: = url(../../images/download.jpg); BACKGROUND-REPEAT: no-repeat; = TEXT-ALIGN: left } .graphicalAbstractDownloadLink { FONT-SIZE: 10px; COLOR: #000; TEXT-DECORATION: underline } #videodiv { HEIGHT: 300px } #audiodiv { HEIGHT: 55px } #videoPlayerHolder DIV P { DISPLAY: block; FONT-WEIGHT: normal; COLOR: #000000; TEXT-ALIGN: left } #videoPlayerHolder DIV P A { COLOR: #005789; TEXT-DECORATION: underline } #audioPlayerHolder DIV P { DISPLAY: block; FONT-WEIGHT: normal; COLOR: #000000; TEXT-ALIGN: left } #audioPlayerHolder DIV P A { COLOR: #005789; TEXT-DECORATION: underline } .figuresActivate { PADDING-RIGHT: 2px; BACKGROUND-POSITION: left 50%; BORDER-TOP: #c5d8ed = 1px solid; PADDING-LEFT: 4px; BACKGROUND-IMAGE: = url(../../images/stripbg.gif); PADDING-BOTTOM: 2px; BORDER-LEFT: #455e8d = 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #455e8d 1px solid; = BACKGROUND-REPEAT: repeat; BACKGROUND-COLOR: #455e8d; = BORDER-RIGHT-WIDTH: 0px! important } .figuresActivate A { COLOR: #000000; TEXT-DECORATION: none } .figuresActivate A:hover SPAN { BACKGROUND: none transparent scroll repeat 0% 0% } #figuresActivate { =09 } .audioVideoActivate { PADDING-RIGHT: 2px; BACKGROUND-POSITION: left 50%; BORDER-TOP: #839ac6 = 1px solid; PADDING-LEFT: 4px; BACKGROUND-IMAGE: = url(../../images/stripbg.gif); PADDING-BOTTOM: 2px; BORDER-LEFT: #839ac6 = 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #839ac6 1px solid; = BACKGROUND-REPEAT: repeat; BACKGROUND-COLOR: #839ac6; = BORDER-RIGHT-WIDTH: 0px! important } #audioVideoActivate { =09 } .audioVideoActivate A { COLOR: #000000; TEXT-DECORATION: none } .audioVideoActivate A:hover SPAN { BACKGROUND: none transparent scroll repeat 0% 0% } .wordDocActivate { PADDING-RIGHT: 2px; BACKGROUND-POSITION: left 50%; BORDER-TOP: #839ac6 = 1px solid; PADDING-LEFT: 4px; BACKGROUND-IMAGE: = url(../../images/stripbg.gif); PADDING-BOTTOM: 2px; BORDER-LEFT: #b8c9e5 = 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #b8c9e5 1px solid; = BACKGROUND-REPEAT: repeat; BACKGROUND-COLOR: #b8c9e5; = BORDER-RIGHT-WIDTH: 0px! important } #wordDocActivate { =09 } .wordDocActivate A { COLOR: #000000; TEXT-DECORATION: none } .wordDocActivate A:hover SPAN { BACKGROUND: none transparent scroll repeat 0% 0% } .excelActivate { PADDING-RIGHT: 2px; BACKGROUND-POSITION: left 50%; BORDER-TOP: #839ac6 = 1px solid; PADDING-LEFT: 4px; BACKGROUND-IMAGE: = url(../../images/stripbg.gif); PADDING-BOTTOM: 2px; BORDER-LEFT: #8fc668 = 1px solid; PADDING-TOP: 2px; BORDER-BOTTOM: #8fc668 1px solid; = BACKGROUND-REPEAT: repeat; BACKGROUND-COLOR: #8fc668; = BORDER-RIGHT-WIDTH: 0px! important } #excelActivate { =09 } .excelActivate A { COLOR: #000000; TEXT-DECORATION: none } .excelActivate A:hover SPAN { BACKGROUND: none transparent scroll repeat 0% 0% } .otherActivate { BACKGROUND-POSITION: left 50%; BORDER-TOP: #839ac6 1px solid; = BACKGROUND-IMAGE: url(../../images/stripbg.gif); BORDER-LEFT: #e3ecfd = 1px solid; BORDER-BOTTOM: #e3ecfd 1px solid; BACKGROUND-REPEAT: repeat; = BACKGROUND-COLOR: #e3ecfd; BORDER-RIGHT-WIDTH: 0px! important } #otherActivate { =09 } .otherActivate A { COLOR: #000000; TEXT-DECORATION: none } .otherActivate A:hover SPAN { BACKGROUND: none transparent scroll repeat 0% 0% } .pdfActivate { BORDER-TOP: #839ac6 1px solid; BACKGROUND-IMAGE: = url(../../images/stripbg.gif); BORDER-LEFT: #e0e0e0 1px solid; = BORDER-BOTTOM: #8fc668 0px solid; BACKGROUND-REPEAT: repeat; = BACKGROUND-COLOR: #e0e0e0; BORDER-RIGHT-WIDTH: 0px! important } #pdfActivate { =09 } .pdfActivate A { COLOR: #000000; TEXT-DECORATION: none } .pdfActivate A:hover SPAN { BACKGROUND: none transparent scroll repeat 0% 0% } .audioVideoItems { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .audioVideoItems LI { BORDER-RIGHT: #666 1px solid; BORDER-TOP: #666 1px solid; MARGIN-TOP: = 10px; FLOAT: left; MARGIN-LEFT: 5px; BORDER-LEFT: #666 1px solid; = MARGIN-RIGHT: 5px; BORDER-BOTTOM: #666 1px solid; LIST-STYLE-TYPE: none } .pdfItems { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .pdfItems LI { BORDER-RIGHT: #dc0d0d 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #dc0d0d 1px solid; MARGIN-TOP: 2px; PADDING-LEFT: 2px; FLOAT: left; = PADDING-BOTTOM: 2px; MARGIN-LEFT: 5px; BORDER-LEFT: #dc0d0d 1px solid; = WIDTH: 160px; CURSOR: pointer; MARGIN-RIGHT: 5px; PADDING-TOP: 2px; = BORDER-BOTTOM: #dc0d0d 1px solid; LIST-STYLE-TYPE: none; HEIGHT: 116px; = BACKGROUND-COLOR: #ffffff } .itemspdfType { DISPLAY: block; PADDING-LEFT: 19px; BACKGROUND-IMAGE: = url(../../images/pdft.gif); MARGIN-BOTTOM: 5px; PADDING-TOP: 2px; = BORDER-BOTTOM: #dc0d0d 1px dotted; BACKGROUND-REPEAT: no-repeat; HEIGHT: = 18px; BACKGROUND-COLOR: #e0e0e0 } .openpdfsupplink { PADDING-RIGHT: 17px; BACKGROUND-POSITION: right 50%; FONT-SIZE: 9px; = BACKGROUND-IMAGE: url(../../images/cell/opennew.jpg); PADDING-TOP: 2px; = BACKGROUND-REPEAT: no-repeat } .documentItems { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .documentItems LI { BORDER-RIGHT: #577cc2 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #577cc2 1px solid; MARGIN-TOP: 2px; PADDING-LEFT: 2px; FLOAT: left; = PADDING-BOTTOM: 2px; MARGIN-LEFT: 5px; BORDER-LEFT: #577cc2 1px solid; = WIDTH: 120px; CURSOR: pointer; MARGIN-RIGHT: 5px; PADDING-TOP: 2px; = BORDER-BOTTOM: #577cc2 1px solid; LIST-STYLE-TYPE: none; HEIGHT: 116px; = BACKGROUND-COLOR: #ffffff } .itemsdocType { DISPLAY: block; PADDING-LEFT: 19px; BACKGROUND-IMAGE: = url(../../images/docx.ico); MARGIN-BOTTOM: 5px; PADDING-TOP: 2px; = BORDER-BOTTOM: #577cc2 1px dotted; BACKGROUND-REPEAT: no-repeat; HEIGHT: = 18px; BACKGROUND-COLOR: #b8c9e5 } .itemssimpletext { DISPLAY: block; FONT-SIZE: 11px; OVERFLOW: auto; HEIGHT: 90px } .downloaddocsupplink { PADDING-RIGHT: 17px; BACKGROUND-POSITION: right 50%; FONT-SIZE: 9px; = BACKGROUND-IMAGE: url(../../images/download.jpg); PADDING-TOP: 2px; = BACKGROUND-REPEAT: no-repeat } .itemsexcelType { DISPLAY: block; PADDING-LEFT: 19px; BACKGROUND-IMAGE: = url(../../images/xlsx.ico); MARGIN-BOTTOM: 5px; PADDING-TOP: 2px; = BORDER-BOTTOM: #6a934c 1px dotted; BACKGROUND-REPEAT: no-repeat; HEIGHT: = 18px; BACKGROUND-COLOR: #8fc668 } .downloadexcelsupplink { PADDING-RIGHT: 17px; BACKGROUND-POSITION: right 50%; FONT-SIZE: 9px; = BACKGROUND-IMAGE: url(../../images/download.jpg); PADDING-TOP: 2px; = BORDER-BOTTOM: #6a934c 1px dotted; BACKGROUND-REPEAT: no-repeat; = BACKGROUND-COLOR: #8fc668 } .spreadsheetItems { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .spreadsheetItems LI { BORDER-RIGHT: #6a934c 1px solid; PADDING-RIGHT: 2px; BORDER-TOP: = #6a934c 1px solid; MARGIN-TOP: 2px; PADDING-LEFT: 2px; FLOAT: left; = PADDING-BOTTOM: 2px; MARGIN-LEFT: 5px; BORDER-LEFT: #6a934c 1px solid; = WIDTH: 125px; CURSOR: pointer; MARGIN-RIGHT: 5px; PADDING-TOP: 2px; = BORDER-BOTTOM: #6a934c 1px solid; LIST-STYLE-TYPE: none; HEIGHT: 116px; = BACKGROUND-COLOR: #ffffff } .otherItems { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } .otherItems LI { PADDING-RIGHT: 2px; MARGIN-TOP: 2px; PADDING-LEFT: 2px; FLOAT: left; = PADDING-BOTTOM: 2px; MARGIN-LEFT: 5px; WIDTH: 130px; CURSOR: pointer; = MARGIN-RIGHT: 5px; PADDING-TOP: 2px; LIST-STYLE-TYPE: none; HEIGHT: = 116px; BACKGROUND-COLOR: #ffffff } .presentationItem { BORDER-RIGHT: #ff8b62 1px solid; BORDER-TOP: #ff8b62 1px solid; = BORDER-LEFT: #ff8b62 1px solid; BORDER-BOTTOM: #ff8b62 1px solid } .itemspresentType { DISPLAY: block; PADDING-LEFT: 19px; BACKGROUND-IMAGE: = url(../../images/pptx.ico); MARGIN-BOTTOM: 5px; PADDING-TOP: 4px; = BORDER-BOTTOM: #ff8b62 1px dotted; BACKGROUND-REPEAT: no-repeat; HEIGHT: = 18px; BACKGROUND-COLOR: #ff8b62 } .downloadpresentsupplink { PADDING-RIGHT: 16px; BACKGROUND-POSITION: right 50%; FONT-SIZE: 9px; = BACKGROUND-IMAGE: url(../../images/download.jpg); PADDING-TOP: 2px; = BORDER-BOTTOM: #ff8b62 1px dotted; BACKGROUND-REPEAT: no-repeat; = WHITE-SPACE: nowrap; BACKGROUND-COLOR: #ff8b62 } .textItem { BORDER-RIGHT: #34b2b4 1px solid; BORDER-TOP: #34b2b4 1px solid; = BORDER-LEFT: #34b2b4 1px solid; BORDER-BOTTOM: #34b2b4 1px solid } .itemstextType { DISPLAY: block; PADDING-LEFT: 19px; BACKGROUND-IMAGE: = url(../../images/notepad.gif); MARGIN-BOTTOM: 5px; PADDING-TOP: 4px; = BORDER-BOTTOM: #34b2b4 1px dotted; BACKGROUND-REPEAT: no-repeat; HEIGHT: = 18px; BACKGROUND-COLOR: #64e2e4 } .downloadtextsupplink { PADDING-RIGHT: 17px; BACKGROUND-POSITION: right 50%; FONT-SIZE: 9px; = BACKGROUND-IMAGE: url(../../images/download.jpg); PADDING-TOP: 2px; = BORDER-BOTTOM: #34b2b4 1px dotted; BACKGROUND-REPEAT: no-repeat; = BACKGROUND-COLOR: #64e2e4 } .zipItem { BORDER-RIGHT: #ff8b62 1px solid; BORDER-TOP: #ff8b62 1px solid; = BORDER-LEFT: #ff8b62 1px solid; BORDER-BOTTOM: #ff8b62 1px solid } .itemszipType { DISPLAY: block; PADDING-LEFT: 19px; BACKGROUND-IMAGE: = url(../../images/zip-file-icon.gif); MARGIN-BOTTOM: 5px; PADDING-TOP: = 4px; BORDER-BOTTOM: #cc9e04 1px dotted; BACKGROUND-REPEAT: no-repeat; = HEIGHT: 18px; BACKGROUND-COLOR: #fcce34 } .downloadzipsupplink { PADDING-RIGHT: 17px; BACKGROUND-POSITION: right 50%; FONT-SIZE: 9px; = BACKGROUND-IMAGE: url(../../images/download.jpg); PADDING-TOP: 2px; = BORDER-BOTTOM: #cc9e04 1px dotted; BACKGROUND-REPEAT: no-repeat; = BACKGROUND-COLOR: #fcce34 } .figurePanel { FONT-SIZE: 11px; FLOAT: left } #panelActivators LI A { CURSOR: pointer } #videostrip { PADDING-RIGHT: 4px; DISPLAY: block; PADDING-LEFT: 4px; BACKGROUND: = url(../../images/stripbg.gif) #839ac6; PADDING-BOTTOM: 4px; WIDTH: = 2200px; PADDING-TOP: 4px; WHITE-SPACE: nowrap; LIST-STYLE-TYPE: none; = HEIGHT: 126px; TEXT-ALIGN: center } #videostrip LI { CLEAR: none; FLOAT: left } #videostrip LI A { COLOR: #000000; TEXT-DECORATION: underline } #videostrip LI A:hover { CURSOR: pointer; TEXT-DECORATION: none } #videostrip LI A { PADDING-RIGHT: 4px; DISPLAY: block; PADDING-LEFT: 4px; PADDING-BOTTOM: = 4px; PADDING-TOP: 4px; TEXT-DECORATION: none } #videostrip LI A SPAN { CLEAR: left; DISPLAY: block; TEXT-DECORATION: underline } #videostrip LI A:hover { BACKGROUND: #999 } #videostrip LI A:hover SPAN { CLEAR: left; DISPLAY: block; TEXT-DECORATION: none } #videostrip LI.active { FONT-WEIGHT: bold; BACKGROUND: #bbb; COLOR: black; TEXT-DECORATION: = none! important } .suppinfo UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; MARGIN: 5px = 0px 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #ccc 1px dotted; = LIST-STYLE-TYPE: none } .suppinfo UL.suppinfoheader { BORDER-TOP-WIDTH: 0px; MARGIN-TOP: 0px; BORDER-LEFT-WIDTH: 0px; = BORDER-BOTTOM-WIDTH: 0px; MARGIN-BOTTOM: -10px; BORDER-RIGHT-WIDTH: 0px } .suppinfo A { FONT-SIZE: 12px; COLOR: #005789; TEXT-DECORATION: none } .suppinfo A:hover { TEXT-DECORATION: underline } .suppinfo UL LI { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; = LINE-HEIGHT: 1.6em; PADDING-TOP: 3px } .suppinfo UL LI.suppinfolink { BACKGROUND-COLOR: transparent } .CollapsiblePanelContent A.tip { COLOR: #005789; TEXT-DECORATION: none } .CollapsiblePanelContent A.tip:hover { TEXT-DECORATION: underline } #authorinterviewcarrier { BORDER-RIGHT: #dc9600 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #dc9600 1px solid; PADDING-LEFT: 5px; VISIBILITY: hidden; = PADDING-BOTTOM: 5px; BORDER-LEFT: #dc9600 1px solid; WIDTH: 320px; = PADDING-TOP: 5px; BORDER-BOTTOM: #dc9600 1px solid; POSITION: absolute; = HEIGHT: 30px; BACKGROUND-COLOR: #fcd811 } UL.toolbar LI.audiotool { BACKGROUND-POSITION: left 50%; MARGIN-TOP: 3px; PADDING-LEFT: 28px; = FONT-WEIGHT: bold; FONT-SIZE: 11px; FLOAT: right; BACKGROUND-IMAGE: = url(../../images/Cell/paperclipleft.gif); CURSOR: pointer; MARGIN-RIGHT: = 5px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 18px } UL.toolbar LI.audiotool SPAN { PADDING-RIGHT: 5px; BACKGROUND-POSITION: right 50%; DISPLAY: block; = BACKGROUND-IMAGE: url(../../images/Cell/paperclipright.gif); = PADDING-BOTTOM: 2px; CURSOR: pointer; PADDING-TOP: 2px; = BACKGROUND-REPEAT: no-repeat } UL.toolbar LI.audiotoolon { BACKGROUND-POSITION: left 50%; MARGIN-TOP: 3px; PADDING-LEFT: 28px; = FONT-WEIGHT: bold; FONT-SIZE: 11px; FLOAT: right; BACKGROUND-IMAGE: = url(../../images/Cell/paperclipleftmo.gif); CURSOR: pointer; = MARGIN-RIGHT: 5px; BACKGROUND-REPEAT: no-repeat; HEIGHT: 18px } UL.toolbar LI.audiotoolon SPAN { PADDING-RIGHT: 5px; BACKGROUND-POSITION: right 50%; DISPLAY: block; = BACKGROUND-IMAGE: url(../../images/Cell/papercliprightmo.gif); = PADDING-BOTTOM: 2px; CURSOR: pointer; PADDING-TOP: 2px; = BACKGROUND-REPEAT: no-repeat } UL.toolbar LI.audiotool A { BACKGROUND-POSITION: left 4px; WIDTH: 16px; BACKGROUND-REPEAT: = no-repeat; HEIGHT: 24px } .audioPlayerMessage { DISPLAY: inline; WIDTH: 16px; PADDING-TOP: 4px; POSITION: relative; = HEIGHT: 20px } #audioPlayerClick { DISPLAY: inline; WIDTH: 16px; PADDING-TOP: 4px; POSITION: relative; = HEIGHT: 20px } .audioPlayerInfo { FONT-WEIGHT: normal; COLOR: #000; LIST-STYLE-TYPE: none; TEXT-ALIGN: = left } .flashPlayerHolder { FONT-SIZE: 11px! important; TEXT-ALIGN: left } #summary A.tip { COLOR: #005789; TEXT-DECORATION: none } #summary A.tip:hover { TEXT-DECORATION: underline } #refauthfiltermenuitems { BORDER-RIGHT: #cccccc 1px solid; PADDING-RIGHT: 5px; = BACKGROUND-POSITION: 50% top; BORDER-TOP: #cccccc 1px solid; = PADDING-LEFT: 5px; FONT-SIZE: 11px; BACKGROUND-IMAGE: = url(../../images/affiback.gif); PADDING-BOTTOM: 5px; OVERFLOW: visible; = BORDER-LEFT: #cccccc 1px solid; PADDING-TOP: 5px; BORDER-BOTTOM: #cccccc = 1px solid; BACKGROUND-REPEAT: repeat-x; HEIGHT: auto; BACKGROUND-COLOR: = #ebeff9 } #refauthfiltermenuitems SPAN { PADDING-RIGHT: 5px; DISPLAY: block; PADDING-LEFT: 5px; Z-INDEX: 999999; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px } #refauthfiltermenuitems UL { FLOAT: left; WIDTH: 120px; LIST-STYLE-TYPE: none } #refauthfiltermenuitems UL LI { DISPLAY: block; PADDING-BOTTOM: 1px; WIDTH: 100px; COLOR: #000000; = PADDING-TOP: 1px; TEXT-ALIGN: left } #refauthfiltermenuitems UL LI A { DISPLAY: block; WIDTH: 100%; COLOR: #000000; HEIGHT: 100%; = TEXT-DECORATION: none } #refauthfiltermenuitems UL LI A:hover { DISPLAY: block; WIDTH: 100%; COLOR: #ffffff; HEIGHT: 100%; = BACKGROUND-COLOR: #039 } #refauthfiltermenu { DISPLAY: none; LEFT: 0px; COLOR: #ffffff; POSITION: absolute; TOP: 0px } #reffiltertab { PADDING-RIGHT: 0px; DISPLAY: block; PADDING-LEFT: 5px; PADDING-BOTTOM: = 2px; MARGIN: 0px; PADDING-TOP: 2px; HEIGHT: 20px; BACKGROUND-COLOR: = #666666; TEXT-ALIGN: left } #authorlastnamefirstli { PADDING-LEFT: 0px; FLOAT: left; MARGIN-LEFT: 0px; PADDING-TOP: 3px } #authorlastnamesecondli { PADDING-LEFT: 0px; FLOAT: left; MARGIN-LEFT: 2px } #authorlastnamethirdli { BACKGROUND-POSITION: left 50%; DISPLAY: block; PADDING-LEFT: 0px; = FLOAT: right; BACKGROUND-IMAGE: url(../../images/close.gif); = MARGIN-LEFT: 5px; WIDTH: 20px; PADDING-TOP: 3px; BACKGROUND-REPEAT: = no-repeat; TEXT-DECORATION: none } #authorFilterInputUl { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #authorFilterImageDiv { FLOAT: left } #authorFilterOnImage { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: = url(../../images/Cell/filter.gif); WIDTH: 20px; CURSOR: pointer; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 20px } #authorFilterOffImage { DISPLAY: block; FLOAT: left; BACKGROUND-IMAGE: = url(../../images/Cell/filteroff.gif); WIDTH: 20px; CURSOR: pointer; = BACKGROUND-REPEAT: no-repeat; HEIGHT: 20px } #load A.interref { CURSOR: pointer; COLOR: #005789; TEXT-DECORATION: none } #load A.interref:hover { TEXT-DECORATION: underline } .flashAdLeftCorner { BACKGROUND-POSITION: left top; MARGIN-TOP: -6px; BACKGROUND-IMAGE: = url(../../images/cornersLT.gif)! important; MARGIN-LEFT: -6px; = MARGIN-RIGHT: -6px; BACKGROUND-REPEAT: no-repeat } .flashAdRightCorner { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(../../images/cornersRT.gif)! important; BACKGROUND-REPEAT: = no-repeat; HEIGHT: 6px } .jobsAdTopLeftCorner { BACKGROUND-POSITION: left top; BACKGROUND-IMAGE: = url(../../images/cornersLT.gif)! important; BACKGROUND-REPEAT: no-repeat } .jobsAdTopRightCorner { BACKGROUND-POSITION: right top; BACKGROUND-IMAGE: = url(../../images/cornersRT.gif)! important; BACKGROUND-REPEAT: no-repeat } .jobsAdBottomLeftCorner { BACKGROUND-POSITION: left bottom; LEFT: 0px; BACKGROUND-IMAGE: = url(../../images/cornersLB.gif)! important; WIDTH: 100%; = BACKGROUND-REPEAT: no-repeat; POSITION: absolute; TOP: 264px } .jobsAdBottomRightCorner { BACKGROUND-POSITION: right bottom; BACKGROUND-IMAGE: = url(../../images/cornersRB.gif)! important; WIDTH: 100%; = BACKGROUND-REPEAT: no-repeat } ------=_NextPart_000_0000_01CAFDBC.7EA03CF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cell.com/js/cell/bubble.js function findPosY(obj) { var curtop =3D 0; if(obj.offsetParent) { while(1) { curtop +=3D obj.offsetTop; if(!obj.offsetParent) { break; } obj =3D obj.offsetParent; } } else if(obj.y) { curtop +=3D obj.y; } return curtop; } function getWindowHeight() { var windowHeight=3D0; if(typeof(window.innerHeight) =3D=3D 'number') { windowHeight =3D window.innerHeight; } else { if(document.documentElement && = document.documentElement.clientHeight) { windowHeight =3D document.documentElement.clientHeight; } else { if(document.body && document.body.clientHeight) { windowHeight =3D document.body.clientHeight; } } } return windowHeight; } var OPAC =3D 0; var InfoBubble =3D { bubbleTimeout: 1, currentBubble: null, timeoutBubbleID: null, currentLink: null, show: function(aID, bID) { var disableFade =3D 0; if(this.currentBubble) { disableFade =3D 1; } var aBubble =3D document.getElementById(aID); if(aBubble && aBubble !=3D this.currentBubble) { this.hide(); var aBubbleLink =3D document.getElementById(bID); aBubbleLink.style.background =3D '#EFEFEF'; this.currentLink =3D aBubbleLink; if(disableFade =3D=3D 0) { aBubble.style.filter =3D 'alpha(opacity=3D0)'; aBubble.style.opacity =3D 0; } else { aBubble.style.filter =3D ''; aBubble.style.opacity =3D ''; } aBubble.style.display =3D 'inline'; var heightFromTop =3D findPosY(aBubble) - = document.body.scrollTop; if(getWindowHeight() < (aBubble.offsetHeight + = heightFromTop)) { //aBubble.style.top =3D (getWindowHeight() - = (aBubble.offsetHeight + heightFromTop)) - 5; } else { if(heightFromTop < 0) { aBubble.style.top =3D (Math.abs(heightFromTop)) + 5; } else { aBubble.style.top =3D 5; } } this.currentBubble =3D aBubble; if(disableFade =3D=3D 0) { setTimeout('InfoBubble.fadeIn()',300); OPAC =3D 0; } } if(this.timeoutBubbleID) { clearTimeout(this.timeoutBubbleID); } }, hide: function() { if(this.currentBubble) { this.currentLink.style.background =3D '#FFFFFF'; this.currentBubble.style.display =3D 'none'; this.currentBubble.style.top =3D 0; this.currentBubble =3D null; if(this.timeoutBubbleID) { clearTimeout(this.timeoutBubbleID); }=20 } }, timeout: function() { if(OPAC =3D=3D 0) { InfoBubble.hide(); } else { this.timeoutBubbleID =3D setTimeout('InfoBubble.hide()', = this.bubbleTimeout * 1000); } }, fadeIn: function() { if(this.currentBubble) { OPAC =3D OPAC + .10; OPAC =3D (OPAC>1)?1:OPAC; this.currentBubble.style.filter =3D = 'alpha(opacity=3D'+parseInt(100*OPAC)+')'; this.currentBubble.style.opacity =3D OPAC; if(OPAC<1) { setTimeout('InfoBubble.fadeIn()',25); } } } } ------=_NextPart_000_0000_01CAFDBC.7EA03CF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.cell.com/js/ajax/ajaxEngine.js /* * Copyright 2005 Joe Walker * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. * You may obtain a copy of the License at * * http://www.apache.org/licenses/LICENSE-2.0 * * Unless required by applicable law or agreed to in writing, software * distributed under the License is distributed on an "AS IS" BASIS, * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or = implied. * See the License for the specific language governing permissions and * limitations under the License. */ /** * Declare an object to which we can add real functions. */ if (dwr =3D=3D null) var dwr =3D {}; if (dwr.engine =3D=3D null) dwr.engine =3D {}; if (DWREngine =3D=3D null) var DWREngine =3D dwr.engine; /** * Set an alternative error handler from the default alert box. * @see getahead.org/dwr/browser/engine/errors */ dwr.engine.setErrorHandler =3D function(handler) { dwr.engine._errorHandler =3D handler; }; /** * Set an alternative warning handler from the default alert box. * @see getahead.org/dwr/browser/engine/errors */ dwr.engine.setWarningHandler =3D function(handler) { dwr.engine._warningHandler =3D handler; }; /** * Setter for the text/html handler - what happens if a DWR request gets = an HTML * reply rather than the expected Javascript. Often due to login timeout */ dwr.engine.setTextHtmlHandler =3D function(handler) { dwr.engine._textHtmlHandler =3D handler; }; /** * Set a default timeout value for all calls. 0 (the default) turns = timeouts off. * @see getahead.org/dwr/browser/engine/errors */ dwr.engine.setTimeout =3D function(timeout) { dwr.engine._timeout =3D timeout; }; /** * The Pre-Hook is called before any DWR remoting is done. * @see getahead.org/dwr/browser/engine/hooks */ dwr.engine.setPreHook =3D function(handler) { dwr.engine._preHook =3D handler; }; /** * The Post-Hook is called after any DWR remoting is done. * @see getahead.org/dwr/browser/engine/hooks */ dwr.engine.setPostHook =3D function(handler) { dwr.engine._postHook =3D handler; }; /** * Custom headers for all DWR calls * @see getahead.org/dwr/???? */ dwr.engine.setHeaders =3D function(headers) { dwr.engine._headers =3D headers; }; /** * Custom parameters for all DWR calls * @see getahead.org/dwr/???? */ dwr.engine.setParameters =3D function(parameters) { dwr.engine._parameters =3D parameters; }; /** XHR remoting type constant. See dwr.engine.set[Rpc|Poll]Type() */ dwr.engine.XMLHttpRequest =3D 1; /** XHR remoting type constant. See dwr.engine.set[Rpc|Poll]Type() */ dwr.engine.IFrame =3D 2; /** XHR remoting type constant. See dwr.engine.setRpcType() */ dwr.engine.ScriptTag =3D 3; /** * Set the preferred remoting type. * @param newType One of dwr.engine.XMLHttpRequest or dwr.engine.IFrame = or dwr.engine.ScriptTag * @see getahead.org/dwr/browser/engine/options */ dwr.engine.setRpcType =3D function(newType) { if (newType !=3D dwr.engine.XMLHttpRequest && newType !=3D = dwr.engine.IFrame && newType !=3D dwr.engine.ScriptTag) { dwr.engine._handleError(null, { name:"dwr.engine.invalidRpcType", = message:"RpcType must be one of dwr.engine.XMLHttpRequest or = dwr.engine.IFrame or dwr.engine.ScriptTag" }); return; } dwr.engine._rpcType =3D newType; }; /** * Which HTTP method do we use to send results? Must be one of "GET" or = "POST". * @see getahead.org/dwr/browser/engine/options */ dwr.engine.setHttpMethod =3D function(httpMethod) { if (httpMethod !=3D "GET" && httpMethod !=3D "POST") { dwr.engine._handleError(null, { name:"dwr.engine.invalidHttpMethod", = message:"Remoting method must be one of GET or POST" }); return; } dwr.engine._httpMethod =3D httpMethod; }; /** * Ensure that remote calls happen in the order in which they were sent? = (Default: false) * @see getahead.org/dwr/browser/engine/ordering */ dwr.engine.setOrdered =3D function(ordered) { dwr.engine._ordered =3D ordered; }; /** * Do we ask the XHR object to be asynchronous? (Default: true) * @see getahead.org/dwr/browser/engine/options */ dwr.engine.setAsync =3D function(async) { dwr.engine._async =3D async; }; /** * Does DWR poll the server for updates? (Default: false) * @see getahead.org/dwr/browser/engine/options */ dwr.engine.setActiveReverseAjax =3D function(activeReverseAjax) { if (activeReverseAjax) { // Bail if we are already started if (dwr.engine._activeReverseAjax) return; dwr.engine._activeReverseAjax =3D true; dwr.engine._poll(); } else { // Can we cancel an existing request? if (dwr.engine._activeReverseAjax && dwr.engine._pollReq) = dwr.engine._pollReq.abort(); dwr.engine._activeReverseAjax =3D false; } // TODO: in iframe mode, if we start, stop, start then the second = start may // well kick off a second iframe while the first is still about to = return // we should cope with this but we don't }; /** * The default message handler. * @see getahead.org/dwr/browser/engine/errors */ dwr.engine.defaultErrorHandler =3D function(message, ex) { dwr.engine._debug("Error: " + ex.name + ", " + ex.message, true); if (message =3D=3D null || message =3D=3D "") alert("A server error = has occured."); // Ignore NS_ERROR_NOT_AVAILABLE if Mozilla is being narky else if (message.indexOf("0x80040111") !=3D -1) = dwr.engine._debug(message); else ;//alert(message); }; /** * The default warning handler. * @see getahead.org/dwr/browser/engine/errors */ dwr.engine.defaultWarningHandler =3D function(message, ex) { dwr.engine._debug(message); }; /** * For reduced latency you can group several remote calls together using = a batch. * @see getahead.org/dwr/browser/engine/batch */ dwr.engine.beginBatch =3D function() { if (dwr.engine._batch) { dwr.engine._handleError(null, { name:"dwr.engine.batchBegun", = message:"Batch already begun" }); return; } dwr.engine._batch =3D dwr.engine._createBatch(); }; /** * Finished grouping a set of remote calls together. Go and execute them = all. * @see getahead.org/dwr/browser/engine/batch */ dwr.engine.endBatch =3D function(options) { var batch =3D dwr.engine._batch; if (batch =3D=3D null) { dwr.engine._handleError(null, { name:"dwr.engine.batchNotBegun", = message:"No batch in progress" }); return; } dwr.engine._batch =3D null; if (batch.map.callCount =3D=3D 0) return; // The hooks need to be merged carefully to preserve ordering if (options) dwr.engine._mergeBatch(batch, options); // In ordered mode, we don't send unless the list of sent items is = empty if (dwr.engine._ordered && dwr.engine._batchesLength !=3D 0) { dwr.engine._batchQueue[dwr.engine._batchQueue.length] =3D batch; } else { dwr.engine._sendData(batch); } }; /** @deprecated */ dwr.engine.setPollMethod =3D function(type) { = dwr.engine.setPollType(type); }; dwr.engine.setMethod =3D function(type) { dwr.engine.setRpcType(type); = }; dwr.engine.setVerb =3D function(verb) { dwr.engine.setHttpMethod(verb); = }; dwr.engine.setPollType =3D function() { dwr.engine._debug("Manually = setting the Poll Type is not supported"); }; //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D // Only private stuff below here //=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D /** The original page id sent from the server */ dwr.engine._origScriptSessionId =3D "31D50418F72B5CA6D2388004A4193F37"; /** The session cookie name */ dwr.engine._sessionCookieName =3D "JSESSIONID"; // JSESSIONID /** Is GET enabled for the benefit of Safari? */ dwr.engine._allowGetForSafariButMakeForgeryEasier =3D "false"; /** The script prefix to strip in the case of scriptTagProtection. */ dwr.engine._scriptTagProtection =3D "throw 'allowScriptTagRemoting is = false.';"; /** The default path to the DWR servlet */ dwr.engine._defaultPath =3D "/Cell/dwr"; /** Do we use XHR for reverse ajax because we are not streaming? */ dwr.engine._pollWithXhr =3D "false"; /** The read page id that we calculate */ dwr.engine._scriptSessionId =3D null; /** The function that we use to fetch/calculate a session id */ dwr.engine._getScriptSessionId =3D function() { if (dwr.engine._scriptSessionId =3D=3D null) { dwr.engine._scriptSessionId =3D dwr.engine._origScriptSessionId + = Math.floor(Math.random() * 1000); } return dwr.engine._scriptSessionId; }; /** A function to call if something fails. */ dwr.engine._errorHandler =3D dwr.engine.defaultErrorHandler; /** For debugging when something unexplained happens. */ dwr.engine._warningHandler =3D dwr.engine.defaultWarningHandler; /** A function to be called before requests are marshalled. Can be null. = */ dwr.engine._preHook =3D null; /** A function to be called after replies are received. Can be null. */ dwr.engine._postHook =3D null; /** An map of the batches that we have sent and are awaiting a reply on. = */ dwr.engine._batches =3D {}; /** A count of the number of outstanding batches. Should be =3D=3D to = _batches.length unless prototype has messed things up */ dwr.engine._batchesLength =3D 0; /** In ordered mode, the array of batches waiting to be sent */ dwr.engine._batchQueue =3D []; /** What is the default rpc type */ dwr.engine._rpcType =3D dwr.engine.XMLHttpRequest; /** What is the default remoting method (ie GET or POST) */ dwr.engine._httpMethod =3D "POST"; /** Do we attempt to ensure that calls happen in the order in which they = were sent? */ dwr.engine._ordered =3D false; /** Do we make the calls async? */ dwr.engine._async =3D true; /** The current batch (if we are in batch mode) */ dwr.engine._batch =3D null; /** The global timeout */ dwr.engine._timeout =3D 0; /** ActiveX objects to use when we want to convert an xml string into a = DOM object. */ dwr.engine._DOMDocument =3D ["Msxml2.DOMDocument.6.0", = "Msxml2.DOMDocument.5.0", "Msxml2.DOMDocument.4.0", = "Msxml2.DOMDocument.3.0", "MSXML2.DOMDocument", "MSXML.DOMDocument", = "Microsoft.XMLDOM"]; /** The ActiveX objects to use when we want to do an XMLHttpRequest = call. */ dwr.engine._XMLHTTP =3D ["Msxml2.XMLHTTP.6.0", "Msxml2.XMLHTTP.5.0", = "Msxml2.XMLHTTP.4.0", "MSXML2.XMLHTTP.3.0", "MSXML2.XMLHTTP", = "Microsoft.XMLHTTP"]; /** Are we doing comet or polling? */ dwr.engine._activeReverseAjax =3D false; /** The iframe that we are using to poll */ dwr.engine._outstandingIFrames =3D []; /** The xhr object that we are using to poll */ dwr.engine._pollReq =3D null; /** How many milliseconds between internal comet polls */ dwr.engine._pollCometInterval =3D 200; /** How many times have we re-tried to poll? */ dwr.engine._pollRetries =3D 0; dwr.engine._maxPollRetries =3D 0; /** Do we do a document.reload if we get a text/html reply? */ dwr.engine._textHtmlHandler =3D null; /** If you wish to send custom headers with every request */ dwr.engine._headers =3D null; /** If you wish to send extra custom request parameters with each = request */ dwr.engine._parameters =3D null; /** Undocumented interceptors - do not use */ dwr.engine._postSeperator =3D "\n"; dwr.engine._defaultInterceptor =3D function(data) { return data; }; dwr.engine._urlRewriteHandler =3D dwr.engine._defaultInterceptor; dwr.engine._contentRewriteHandler =3D dwr.engine._defaultInterceptor; dwr.engine._replyRewriteHandler =3D dwr.engine._defaultInterceptor; /** Batch ids allow us to know which batch the server is answering */ dwr.engine._nextBatchId =3D 0; /** A list of the properties that need merging from calls to a batch */ dwr.engine._propnames =3D [ "rpcType", "httpMethod", "async", "timeout", = "errorHandler", "warningHandler", "textHtmlHandler" ]; /** Do we stream, or can be hacked to do so? */ dwr.engine._partialResponseNo =3D 0; dwr.engine._partialResponseYes =3D 1; dwr.engine._partialResponseFlush =3D 2; /** * @private Send a request. Called by the Javascript interface stub * @param path part of URL after the host and before the exec bit = without leading or trailing /s * @param scriptName The class to execute * @param methodName The method on said class to execute * @param func The callback function to which any returned data should = be passed * if this is null, any returned data will be ignored * @param vararg_params The parameters to pass to the above class */ dwr.engine._execute =3D function(path, scriptName, methodName, = vararg_params) { var singleShot =3D false; if (dwr.engine._batch =3D=3D null) { dwr.engine.beginBatch(); singleShot =3D true; } var batch =3D dwr.engine._batch; // To make them easy to manipulate we copy the arguments into an args = array var args =3D []; for (var i =3D 0; i < arguments.length - 3; i++) { args[i] =3D arguments[i + 3]; } // All the paths MUST be to the same servlet if (batch.path =3D=3D null) { batch.path =3D path; } else { if (batch.path !=3D path) { dwr.engine._handleError(batch, { = name:"dwr.engine.multipleServlets", message:"Can't batch requests to = multiple DWR Servlets." }); return; } } // From the other params, work out which is the function (or object = with // call meta-data) and which is the call parameters var callData; var lastArg =3D args[args.length - 1]; if (typeof lastArg =3D=3D "function" || lastArg =3D=3D null) callData = =3D { callback:args.pop() }; else callData =3D args.pop(); // Merge from the callData into the batch dwr.engine._mergeBatch(batch, callData); batch.handlers[batch.map.callCount] =3D { exceptionHandler:callData.exceptionHandler, callback:callData.callback }; // Copy to the map the things that need serializing var prefix =3D "c" + batch.map.callCount + "-"; batch.map[prefix + "scriptName"] =3D scriptName; batch.map[prefix + "methodName"] =3D methodName; batch.map[prefix + "id"] =3D batch.map.callCount; for (i =3D 0; i < args.length; i++) { dwr.engine._serializeAll(batch, [], args[i], prefix + "param" + i); } // Now we have finished remembering the call, we incr the call count batch.map.callCount++; if (singleShot) dwr.engine.endBatch(); }; /** @private Poll the server to see if there is any data waiting */ dwr.engine._poll =3D function(overridePath) { if (!dwr.engine._activeReverseAjax) return; var batch =3D dwr.engine._createBatch(); batch.map.id =3D 0; // TODO: Do we need this?? batch.map.callCount =3D 1; batch.isPoll =3D true; if (dwr.engine._pollWithXhr =3D=3D "true") { batch.rpcType =3D dwr.engine.XMLHttpRequest; batch.map.partialResponse =3D dwr.engine._partialResponseNo; } else { if (navigator.userAgent.indexOf("Gecko/") !=3D -1) { batch.rpcType =3D dwr.engine.XMLHttpRequest; batch.map.partialResponse =3D dwr.engine._partialResponseYes; } // else if (navigator.userAgent.indexOf("; MSIE")) { // batch.rpcType =3D dwr.engine.IFrame; // batch.map.partialResponse =3D dwr.engine._partialResponseYes; // } else if (navigator.userAgent.indexOf("Safari/")) { batch.rpcType =3D dwr.engine.XMLHttpRequest; batch.map.partialResponse =3D dwr.engine._partialResponseYes; } else { batch.rpcType =3D dwr.engine.XMLHttpRequest; batch.map.partialResponse =3D dwr.engine._partialResponseNo; } } batch.httpMethod =3D "POST"; batch.async =3D true; batch.timeout =3D 0; batch.path =3D (overridePath) ? overridePath : = dwr.engine._defaultPath; batch.preHooks =3D []; batch.postHooks =3D []; batch.errorHandler =3D dwr.engine._pollErrorHandler; batch.warningHandler =3D dwr.engine._pollErrorHandler; batch.handlers[0] =3D { callback:function(pause) { dwr.engine._pollRetries =3D 0; setTimeout("dwr.engine._poll()", pause); } }; // Send the data dwr.engine._sendData(batch); if (batch.rpcType =3D=3D dwr.engine.XMLHttpRequest && = batch.map.partialResponse =3D=3D dwr.engine._partialResponseYes) { dwr.engine._checkCometPoll(); } }; /** Try to recover from polling errors */ dwr.engine._pollErrorHandler =3D function(msg, ex) { // if anything goes wrong then just silently try again (up to 3x) = after 10s dwr.engine._pollRetries++; dwr.engine._debug("Reverse Ajax poll failed (pollRetries=3D" + = dwr.engine._pollRetries + "): " + ex.name + " : " + ex.message); if (dwr.engine._pollRetries < dwr.engine._maxPollRetries) { setTimeout("dwr.engine._poll()", 10000); } else { dwr.engine._activeReverseAjax =3D false; dwr.engine._debug("Giving up."); } }; /** @private Generate a new standard batch */ dwr.engine._createBatch =3D function() { var batch =3D { map:{ callCount:0, page:window.location.pathname + window.location.search, httpSessionId:dwr.engine._getJSessionId(), scriptSessionId:dwr.engine._getScriptSessionId() }, charsProcessed:0, paramCount:0, parameters:{}, headers:{}, isPoll:false, handlers:{}, preHooks:[], postHooks:[], rpcType:dwr.engine._rpcType, httpMethod:dwr.engine._httpMethod, async:dwr.engine._async, timeout:dwr.engine._timeout, errorHandler:dwr.engine._errorHandler, warningHandler:dwr.engine._warningHandler, textHtmlHandler:dwr.engine._textHtmlHandler }; if (dwr.engine._preHook) batch.preHooks.push(dwr.engine._preHook); if (dwr.engine._postHook) batch.postHooks.push(dwr.engine._postHook); var propname, data; if (dwr.engine._headers) { for (propname in dwr.engine._headers) { data =3D dwr.engine._headers[propname]; if (typeof data !=3D "function") batch.headers[propname] =3D data; } } if (dwr.engine._parameters) { for (propname in dwr.engine._parameters) { data =3D dwr.engine._parameters[propname]; if (typeof data !=3D "function") batch.parameters[propname] =3D = data; } } return batch; }; /** @private Take further options and merge them into */ dwr.engine._mergeBatch =3D function(batch, overrides) { var propname, data; for (var i =3D 0; i < dwr.engine._propnames.length; i++) { propname =3D dwr.engine._propnames[i]; if (overrides[propname] !=3D null) batch[propname] =3D = overrides[propname]; } if (overrides.preHook !=3D null) = batch.preHooks.unshift(overrides.preHook); if (overrides.postHook !=3D null) = batch.postHooks.push(overrides.postHook); if (overrides.headers) { for (propname in overrides.headers) { data =3D overrides.headers[propname]; if (typeof data !=3D "function") batch.headers[propname] =3D data; } } if (overrides.parameters) { for (propname in overrides.parameters) { data =3D overrides.parameters[propname]; if (typeof data !=3D "function") batch.map["p-" + propname] =3D "" = + data; } } }; /** @private What is our session id? */ dwr.engine._getJSessionId =3D function() { var cookies =3D document.cookie.split(';'); for (var i =3D 0; i < cookies.length; i++) { var cookie =3D cookies[i]; while (cookie.charAt(0) =3D=3D ' ') cookie =3D cookie.substring(1, = cookie.length); if (cookie.indexOf(dwr.engine._sessionCookieName + "=3D") =3D=3D 0) = { return cookie.substring(dwr.engine._sessionCookieName.length + 1, = cookie.length); } } return ""; }; /** @private Check for reverse Ajax activity */ dwr.engine._checkCometPoll =3D function() { for (var i =3D 0; i < dwr.engine._outstandingIFrames.length; i++) { var text =3D ""; var iframe =3D dwr.engine._outstandingIFrames[i]; try { text =3D dwr.engine._getTextFromCometIFrame(iframe); } catch (ex) { dwr.engine._handleWarning(iframe.batch, ex); } if (text !=3D "") dwr.engine._processCometResponse(text, = iframe.batch); } if (dwr.engine._pollReq) { var req =3D dwr.engine._pollReq; var text =3D req.responseText; if (text !=3D null) dwr.engine._processCometResponse(text, = req.batch); } // If the poll resources are still there, come back again if (dwr.engine._outstandingIFrames.length > 0 || dwr.engine._pollReq) = { setTimeout("dwr.engine._checkCometPoll()", = dwr.engine._pollCometInterval); } }; /** @private Extract the whole (executed an all) text from the current = iframe */ dwr.engine._getTextFromCometIFrame =3D function(frameEle) { var body =3D frameEle.contentWindow.document.body; if (body =3D=3D null) return ""; var text =3D body.innerHTML; // We need to prevent IE from stripping line feeds if (text.indexOf("

") =3D=3D 0 || text.indexOf("") =3D=3D 0) =
{
    text =3D text.substring(5, text.length - 7);
  }
  return text;
};

/** @private Some more text might have come in, test and execute the new =
stuff */
dwr.engine._processCometResponse =3D function(response, batch) {
  if (batch.charsProcessed =3D=3D response.length) return;
  if (response.length =3D=3D 0) {
    batch.charsProcessed =3D 0;
    return;
  }

  var firstStartTag =3D response.indexOf("//#DWR-START#", =
batch.charsProcessed);
  if (firstStartTag =3D=3D -1) {
    // dwr.engine._debug("No start tag (search from " + =
batch.charsProcessed + "). skipping '" + =
response.substring(batch.charsProcessed) + "'");
    batch.charsProcessed =3D response.length;
    return;
  }
  // if (firstStartTag > 0) {
  //   dwr.engine._debug("Start tag not at start (search from " + =
batch.charsProcessed + "). skipping '" + =
response.substring(batch.charsProcessed, firstStartTag) + "'");
  // }

  var lastEndTag =3D response.lastIndexOf("//#DWR-END#");
  if (lastEndTag =3D=3D -1) {
    // dwr.engine._debug("No end tag. unchanged charsProcessed=3D" + =
batch.charsProcessed);
    return;
  }

  // Skip the end tag too for next time, remembering CR and LF
  if (response.charCodeAt(lastEndTag + 11) =3D=3D 13 && =
response.charCodeAt(lastEndTag + 12) =3D=3D 10) {
    batch.charsProcessed =3D lastEndTag + 13;
  }
  else {
    batch.charsProcessed =3D lastEndTag + 11;
  }

  var exec =3D response.substring(firstStartTag + 13, lastEndTag);

  dwr.engine._receivedBatch =3D batch;
  dwr.engine._eval(exec);
  dwr.engine._receivedBatch =3D null;
};

/** @private Actually send the block of data in the batch object. */
dwr.engine._sendData =3D function(batch) {
  batch.map.batchId =3D dwr.engine._nextBatchId;
  dwr.engine._nextBatchId++;
  dwr.engine._batches[batch.map.batchId] =3D batch;
  dwr.engine._batchesLength++;
  batch.completed =3D false;

  for (var i =3D 0; i < batch.preHooks.length; i++) {
    batch.preHooks[i]();
  }
  batch.preHooks =3D null;
  // Set a timeout
  if (batch.timeout && batch.timeout !=3D 0) {
    batch.interval =3D setInterval(function() { =
dwr.engine._abortRequest(batch); }, batch.timeout);
  }
  // Get setup for XMLHttpRequest if possible
  if (batch.rpcType =3D=3D dwr.engine.XMLHttpRequest) {
    if (window.XMLHttpRequest) {
      batch.req =3D new XMLHttpRequest();
    }
    // IE5 for the mac claims to support window.ActiveXObject, but =
throws an error when it's used
    else if (window.ActiveXObject && =
!(navigator.userAgent.indexOf("Mac") >=3D 0 && =
navigator.userAgent.indexOf("MSIE") >=3D 0)) {
      batch.req =3D dwr.engine._newActiveXObject(dwr.engine._XMLHTTP);
    }
  }

  var prop, request;
  if (batch.req) {
    // Proceed using XMLHttpRequest
    if (batch.async) {
      batch.req.onreadystatechange =3D function() {
        if (typeof dwr !=3D 'undefined') dwr.engine._stateChange(batch);
      };
    }
    // If we're polling, record this for monitoring
    if (batch.isPoll) {
      dwr.engine._pollReq =3D batch.req;
      // In IE XHR is an ActiveX control so you can't augment it like =
this
      if (!document.all) batch.req.batch =3D batch;
    }
    // Workaround for Safari 1.x POST bug
    var indexSafari =3D navigator.userAgent.indexOf("Safari/");
    if (indexSafari >=3D 0) {
      var version =3D navigator.userAgent.substring(indexSafari + 7);
      if (parseInt(version, 10) < 400) {
        if (dwr.engine._allowGetForSafariButMakeForgeryEasier =3D=3D =
"true") batch.httpMethod =3D "GET";
        else dwr.engine._handleWarning(batch, { =
name:"dwr.engine.oldSafari", message:"Safari GET support disabled. See =
getahead.org/dwr/server/servlet and =
allowGetForSafariButMakeForgeryEasier." });
      }
    }
    batch.mode =3D batch.isPoll ? dwr.engine._ModePlainPoll : =
dwr.engine._ModePlainCall;
    request =3D dwr.engine._constructRequest(batch);
    try {
      batch.req.open(batch.httpMethod, request.url, batch.async);
      try {
        for (prop in batch.headers) {
          var value =3D batch.headers[prop];
          if (typeof value =3D=3D "string") =
batch.req.setRequestHeader(prop, value);
        }
        if (!batch.headers["Content-Type"]) =
batch.req.setRequestHeader("Content-Type", "text/plain");
      }
      catch (ex) {
        dwr.engine._handleWarning(batch, ex);
      }
      batch.req.send(request.body);
      if (!batch.async) dwr.engine._stateChange(batch);
    }
    catch (ex) {
      dwr.engine._handleError(batch, ex);
    }
  }
  else if (batch.rpcType !=3D dwr.engine.ScriptTag) {
    var idname =3D batch.isPoll ? "dwr-if-poll-" + batch.map.batchId : =
"dwr-if-" + batch.map["c0-id"];
    // on IE try to use the htmlfile activex control
    if (batch.isPoll && window.ActiveXObject) {
      batch.htmlfile =3D new window.ActiveXObject("htmlfile");
      batch.htmlfile.open();
      batch.htmlfile.write("");
      //batch.htmlfile.write("");
      batch.htmlfile.write("");
      batch.htmlfile.close();
      batch.htmlfile.parentWindow.dwr =3D dwr;
      batch.document =3D batch.htmlfile;
    }
    else {
      batch.div =3D document.createElement("div");
      // Add the div to the document first, otherwise IE 6 will ignore =
onload handler.
      document.body.appendChild(batch.div);
      batch.div.innerHTML =3D "<iframe src=3D'javascript:void(0)' =
frameborder=3D'0' style=3D'width:0px;height:0px;border:0;' id=3D'" + =
idname + "' name=3D'" + idname + "' =
onload=3D'dwr.engine._iframeLoadingComplete (" + batch.map.batchId + =
");'>";
      batch.document =3D document;
    }
    batch.iframe =3D batch.document.getElementById(idname);
    batch.iframe.batch =3D batch;
    batch.mode =3D batch.isPoll ? dwr.engine._ModeHtmlPoll : =
dwr.engine._ModeHtmlCall;
    if (batch.isPoll) dwr.engine._outstandingIFrames.push(batch.iframe);
    request =3D dwr.engine._constructRequest(batch);
    if (batch.httpMethod =3D=3D "GET") {
      batch.iframe.setAttribute("src", request.url);
    }
    else {
      batch.form =3D batch.document.createElement("form");
      batch.form.setAttribute("id", "dwr-form");
      batch.form.setAttribute("action", request.url);
      batch.form.setAttribute("target", idname);
      batch.form.target =3D idname;
      batch.form.setAttribute("method", batch.httpMethod);
      for (prop in batch.map) {
        var value =3D batch.map[prop];
        if (typeof value !=3D "function") {
          var formInput =3D batch.document.createElement("input");
          formInput.setAttribute("type", "hidden");
          formInput.setAttribute("name", prop);
          formInput.setAttribute("value", value);
          batch.form.appendChild(formInput);
        }
      }
      batch.document.body.appendChild(batch.form);
      batch.form.submit();
    }
  }
  else {
    batch.httpMethod =3D "GET"; // There's no such thing as ScriptTag =
using POST
    batch.mode =3D batch.isPoll ? dwr.engine._ModePlainPoll : =
dwr.engine._ModePlainCall;
    request =3D dwr.engine._constructRequest(batch);
    batch.script =3D document.createElement("script");
    batch.script.id =3D "dwr-st-" + batch.map["c0-id"];
    batch.script.src =3D request.url;
    document.body.appendChild(batch.script);
  }
};

dwr.engine._ModePlainCall =3D "/call/plaincall/";
dwr.engine._ModeHtmlCall =3D "/call/htmlcall/";
dwr.engine._ModePlainPoll =3D "/call/plainpoll/";
dwr.engine._ModeHtmlPoll =3D "/call/htmlpoll/";

/** @private Work out what the URL should look like */
dwr.engine._constructRequest =3D function(batch) {
  // A quick string to help people that use web log analysers
  var request =3D { url:batch.path + batch.mode, body:null };
  if (batch.isPoll =3D=3D true) {
    request.url +=3D "ReverseAjax.dwr";
  }
  else if (batch.map.callCount =3D=3D 1) {
    request.url +=3D batch.map["c0-scriptName"] + "." + =
batch.map["c0-methodName"] + ".dwr";
  }
  else {
    request.url +=3D "Multiple." + batch.map.callCount + ".dwr";
  }
  // Play nice with url re-writing
  var sessionMatch =3D location.href.match(/jsessionid=3D([^?]+)/);
  if (sessionMatch !=3D null) {
    request.url +=3D ";jsessionid=3D" + sessionMatch[1];
  }

  var prop;
  if (batch.httpMethod =3D=3D "GET") {
    // Some browsers (Opera/Safari2) seem to fail to convert the =
callCount value
    // to a string in the loop below so we do it manually here.
    batch.map.callCount =3D "" + batch.map.callCount;
    request.url +=3D "?";
    for (prop in batch.map) {
      if (typeof batch.map[prop] !=3D "function") {
        request.url +=3D encodeURIComponent(prop) + "=3D" + =
encodeURIComponent(batch.map[prop]) + "&";
      }
    }
    request.url =3D request.url.substring(0, request.url.length - 1);
  }
  else {
    // PERFORMANCE: for iframe mode this is thrown away.
    request.body =3D "";
    for (prop in batch.map) {
      if (typeof batch.map[prop] !=3D "function") {
        request.body +=3D prop + "=3D" + batch.map[prop] + =
dwr.engine._postSeperator;
      }
    }
    request.body =3D dwr.engine._contentRewriteHandler(request.body);
  }
  request.url =3D dwr.engine._urlRewriteHandler(request.url);
  return request;
};

/** @private Called by XMLHttpRequest to indicate that something has =
happened */
dwr.engine._stateChange =3D function(batch) {
  var toEval;

  if (batch.completed) {
    dwr.engine._debug("Error: _stateChange() with batch.completed");
    return;
  }

  var req =3D batch.req;
  try {
    if (req.readyState !=3D 4) return;
  }
  catch (ex) {
    dwr.engine._handleWarning(batch, ex);
    // It's broken - clear up and forget this call
    dwr.engine._clearUp(batch);
    return;
  }

  try {
    var reply =3D req.responseText;
    reply =3D dwr.engine._replyRewriteHandler(reply);
    var status =3D req.status; // causes Mozilla to except on page moves

    if (reply =3D=3D null || reply =3D=3D "") {
      dwr.engine._handleWarning(batch, { name:"dwr.engine.missingData", =
message:"No data received from server" });
    }
    else if (status !=3D 200) {
      dwr.engine._handleError(batch, { name:"dwr.engine.http." + status, =
message:req.statusText });
    }
    else {
      var contentType =3D req.getResponseHeader("Content-Type");
      if (!contentType.match(/^text\/plain/) && =
!contentType.match(/^text\/javascript/)) {
        if (contentType.match(/^text\/html/) && typeof =
batch.textHtmlHandler =3D=3D "function") {
          batch.textHtmlHandler();
        }
        else {
          dwr.engine._handleWarning(batch, { =
name:"dwr.engine.invalidMimeType", message:"Invalid content type: '" + =
contentType + "'" });
        }
      }
      else {
        // Comet replies might have already partially executed
        if (batch.isPoll && batch.map.partialResponse =3D=3D =
dwr.engine._partialResponseYes) {
          dwr.engine._processCometResponse(reply, batch);
        }
        else {
          if (reply.search("//#DWR") =3D=3D -1) {
            dwr.engine._handleWarning(batch, { =
name:"dwr.engine.invalidReply", message:"Invalid reply from server" });
          }
          else {
            toEval =3D reply;
          }
        }
      }
    }
  }
  catch (ex) {
    dwr.engine._handleWarning(batch, ex);
  }

  dwr.engine._callPostHooks(batch);

  // Outside of the try/catch so errors propogate normally:
  dwr.engine._receivedBatch =3D batch;
  if (toEval !=3D null) toEval =3D =
toEval.replace(dwr.engine._scriptTagProtection, "");
  dwr.engine._eval(toEval);
  dwr.engine._receivedBatch =3D null;
  dwr.engine._validateBatch(batch);
  dwr.engine._clearUp(batch);
};

/**
 * @private This function is invoked when a batch reply is received.
 * It checks that there is a response for every call in the batch. =
Otherwise,
 * an error will be signaled (a call without a response indicates that =
the=20
 * server failed to send complete batch response).=20
 */
dwr.engine._validateBatch =3D function(batch) {
  // If some call left unreplied, report an error.
  if (!batch.completed) {
    for (var i =3D 0; i < batch.map.callCount; i++) {
      if (batch.handlers[i] !=3D null) {
        dwr.engine._handleWarning(batch, { =
name:"dwr.engine.incompleteReply", message:"Incomplete reply from =
server" });
        break;
      }
    }
  }
}

/** @private Called from iframe onload, check batch using batch-id */
dwr.engine._iframeLoadingComplete =3D function(batchId) {
  // dwr.engine._checkCometPoll();
  var batch =3D dwr.engine._batches[batchId];
  if (batch) dwr.engine._validateBatch(batch);
}

/** @private Called by the server: Execute a callback */
dwr.engine._remoteHandleCallback =3D function(batchId, callId, reply) {
  var batch =3D dwr.engine._batches[batchId];
  if (batch =3D=3D null) {
    dwr.engine._debug("Warning: batch =3D=3D null in =
remoteHandleCallback for batchId=3D" + batchId, true);
    return;
  }
  // Error handlers inside here indicate an error that is nothing to do
  // with DWR so we handle them differently.
  try {
    var handlers =3D batch.handlers[callId];
    batch.handlers[callId] =3D null;
    if (!handlers) {
      dwr.engine._debug("Warning: Missing handlers. callId=3D" + callId, =
true);
    }
    else if (typeof handlers.callback =3D=3D "function") =
handlers.callback(reply);
  }
  catch (ex) {
    dwr.engine._handleError(batch, ex);
  }
};

/** @private Called by the server: Handle an exception for a call */
dwr.engine._remoteHandleException =3D function(batchId, callId, ex) {
  var batch =3D dwr.engine._batches[batchId];
  if (batch =3D=3D null) { dwr.engine._debug("Warning: null batch in =
remoteHandleException", true); return; }
  var handlers =3D batch.handlers[callId];
  batch.handlers[callId] =3D null;
  if (handlers =3D=3D null) { dwr.engine._debug("Warning: null handlers =
in remoteHandleException", true); return; }
  if (ex.message =3D=3D undefined) ex.message =3D "";
  if (typeof handlers.exceptionHandler =3D=3D "function") =
handlers.exceptionHandler(ex.message, ex);
  else if (typeof batch.errorHandler =3D=3D "function") =
batch.errorHandler(ex.message, ex);
};

/** @private Called by the server: The whole batch is broken */
dwr.engine._remoteHandleBatchException =3D function(ex, batchId) {
  var searchBatch =3D (dwr.engine._receivedBatch =3D=3D null && batchId =
!=3D null);
  if (searchBatch) {
    dwr.engine._receivedBatch =3D dwr.engine._batches[batchId];
  }
  if (ex.message =3D=3D undefined) ex.message =3D "";
  dwr.engine._handleError(dwr.engine._receivedBatch, ex);
  if (searchBatch) {
    dwr.engine._receivedBatch =3D null;
    dwr.engine._clearUp(dwr.engine._batches[batchId]);
  }
};

/** @private Called by the server: Reverse ajax should not be used */
dwr.engine._remotePollCometDisabled =3D function(ex, batchId) {
  dwr.engine.setActiveReverseAjax(false);
  var searchBatch =3D (dwr.engine._receivedBatch =3D=3D null && batchId =
!=3D null);
  if (searchBatch) {
    dwr.engine._receivedBatch =3D dwr.engine._batches[batchId];
  }
  if (ex.message =3D=3D undefined) ex.message =3D "";
  dwr.engine._handleError(dwr.engine._receivedBatch, ex);
  if (searchBatch) {
    dwr.engine._receivedBatch =3D null;
    dwr.engine._clearUp(dwr.engine._batches[batchId]);
  }
};

/** @private Called by the server: An IFrame reply is about to start */
dwr.engine._remoteBeginIFrameResponse =3D function(iframe, batchId) {
  if (iframe !=3D null) dwr.engine._receivedBatch =3D iframe.batch;
  dwr.engine._callPostHooks(dwr.engine._receivedBatch);
};

/** @private Called by the server: An IFrame reply is just completing */
dwr.engine._remoteEndIFrameResponse =3D function(batchId) {
  dwr.engine._clearUp(dwr.engine._receivedBatch);
  dwr.engine._receivedBatch =3D null;
};

/** @private This is a hack to make the context be this window */
dwr.engine._eval =3D function(script) {
  if (script =3D=3D null) return null;
  if (script =3D=3D "") { dwr.engine._debug("Warning: blank script", =
true); return null; }
  // dwr.engine._debug("Exec: [" + script + "]", true);
  return eval(script);
};

/** @private Called as a result of a request timeout */
dwr.engine._abortRequest =3D function(batch) {
  if (batch && !batch.completed) {
    clearInterval(batch.interval);
    dwr.engine._clearUp(batch);
    if (batch.req) batch.req.abort();
    dwr.engine._handleError(batch, { name:"dwr.engine.timeout", =
message:"Timeout" });
  }
};

/** @private call all the post hooks for a batch */
dwr.engine._callPostHooks =3D function(batch) {
  if (batch.postHooks) {
    for (var i =3D 0; i < batch.postHooks.length; i++) {
      batch.postHooks[i]();
    }
    batch.postHooks =3D null;
  }
};

/** @private A call has finished by whatever means and we need to shut =
it all down. */
dwr.engine._clearUp =3D function(batch) {
  if (!batch) { dwr.engine._debug("Warning: null batch in =
dwr.engine._clearUp()", true); return; }
  if (batch.completed =3D=3D "true") { dwr.engine._debug("Warning: =
Double complete", true); return; }

  // IFrame tidyup
  if (batch.div) batch.div.parentNode.removeChild(batch.div);
  if (batch.iframe) {
    // If this is a poll frame then stop comet polling
    for (var i =3D 0; i < dwr.engine._outstandingIFrames.length; i++) {
      if (dwr.engine._outstandingIFrames[i] =3D=3D batch.iframe) {
        dwr.engine._outstandingIFrames.splice(i, 1);
      }
    }
    batch.iframe.parentNode.removeChild(batch.iframe);
  }
  if (batch.form) batch.form.parentNode.removeChild(batch.form);

  // XHR tidyup: avoid IE handles increase
  if (batch.req) {
    // If this is a poll frame then stop comet polling
    if (batch.req =3D=3D dwr.engine._pollReq) dwr.engine._pollReq =3D =
null;
    delete batch.req;
  }

  if (batch.map && batch.map.batchId) {
    delete dwr.engine._batches[batch.map.batchId];
    dwr.engine._batchesLength--;
  }

  batch.completed =3D true;

  // If there is anything on the queue waiting to go out, then send it.
  // We don't need to check for ordered mode, here because when ordered =
mode
  // gets turned off, we still process *waiting* batches in an ordered =
way.
  if (dwr.engine._batchQueue.length !=3D 0) {
    var sendbatch =3D dwr.engine._batchQueue.shift();
    dwr.engine._sendData(sendbatch);
  }
};

/** @private Generic error handling routing to save having null checks =
everywhere */
dwr.engine._handleError =3D function(batch, ex) {
  if (typeof ex =3D=3D "string") ex =3D { name:"unknown", message:ex };
  if (ex.message =3D=3D null) ex.message =3D "";
  if (ex.name =3D=3D null) ex.name =3D "unknown";
  if (batch && typeof batch.errorHandler =3D=3D "function") =
batch.errorHandler(ex.message, ex);
  else if (dwr.engine._errorHandler) =
dwr.engine._errorHandler(ex.message, ex);
  if (batch) dwr.engine._clearUp(batch);
};

/** @private Generic error handling routing to save having null checks =
everywhere */
dwr.engine._handleWarning =3D function(batch, ex) {
  if (typeof ex =3D=3D "string") ex =3D { name:"unknown", message:ex };
  if (ex.message =3D=3D null) ex.message =3D "";
  if (ex.name =3D=3D null) ex.name =3D "unknown";
  if (batch && typeof batch.warningHandler =3D=3D "function") =
batch.warningHandler(ex.message, ex);
  else if (dwr.engine._warningHandler) =
dwr.engine._warningHandler(ex.message, ex);
  if (batch) dwr.engine._clearUp(batch);
};

/**
 * @private Marshall a data item
 * @param batch A map of variables to how they have been marshalled
 * @param referto An array of already marshalled variables to prevent =
recurrsion
 * @param data The data to be marshalled
 * @param name The name of the data being marshalled
 */
dwr.engine._serializeAll =3D function(batch, referto, data, name) {
  if (data =3D=3D null) {
    batch.map[name] =3D "null:null";
    return;
  }

  switch (typeof data) {
  case "boolean":
    batch.map[name] =3D "boolean:" + data;
    break;
  case "number":
    batch.map[name] =3D "number:" + data;
    break;
  case "string":
    batch.map[name] =3D "string:" + encodeURIComponent(data);
    break;
  case "object":
    if (data instanceof String) batch.map[name] =3D "String:" + =
encodeURIComponent(data);
    else if (data instanceof Boolean) batch.map[name] =3D "Boolean:" + =
data;
    else if (data instanceof Number) batch.map[name] =3D "Number:" + =
data;
    else if (data instanceof Date) batch.map[name] =3D "Date:" + =
data.getTime();
    else if (data && data.join) batch.map[name] =3D =
dwr.engine._serializeArray(batch, referto, data, name);
    else batch.map[name] =3D dwr.engine._serializeObject(batch, referto, =
data, name);
    break;
  case "function":
    // We just ignore functions.
    break;
  default:
    dwr.engine._handleWarning(null, { name:"dwr.engine.unexpectedType", =
message:"Unexpected type: " + typeof data + ", attempting default =
converter." });
    batch.map[name] =3D "default:" + data;
    break;
  }
};

/** @private Have we already converted this object? */
dwr.engine._lookup =3D function(referto, data, name) {
  var lookup;
  // Can't use a map: getahead.org/ajax/javascript-gotchas
  for (var i =3D 0; i < referto.length; i++) {
    if (referto[i].data =3D=3D data) {
      lookup =3D referto[i];
      break;
    }
  }
  if (lookup) return "reference:" + lookup.name;
  referto.push({ data:data, name:name });
  return null;
};

/** @private Marshall an object */
dwr.engine._serializeObject =3D function(batch, referto, data, name) {
  var ref =3D dwr.engine._lookup(referto, data, name);
  if (ref) return ref;

  // This check for an HTML is not complete, but is there a better way?
  // Maybe we should add: data.hasChildNodes typeof "function" =3D=3D =
true
  if (data.nodeName && data.nodeType) {
    return dwr.engine._serializeXml(batch, referto, data, name);
  }

  // treat objects as an associative arrays
  var reply =3D "Object_" + dwr.engine._getObjectClassName(data) + ":{";
  var element;
  for (element in data) {
    if (typeof data[element] !=3D "function") {
      batch.paramCount++;
      var childName =3D "c" + dwr.engine._batch.map.callCount + "-e" + =
batch.paramCount;
      dwr.engine._serializeAll(batch, referto, data[element], =
childName);

      reply +=3D encodeURIComponent(element) + ":reference:" + childName =
+ ", ";
    }
  }

  if (reply.substring(reply.length - 2) =3D=3D ", ") {
    reply =3D reply.substring(0, reply.length - 2);
  }
  reply +=3D "}";

  return reply;
};

/** @private Returns the classname of supplied argument obj */
dwr.engine._errorClasses =3D { "Error":Error, "EvalError":EvalError, =
"RangeError":RangeError, "ReferenceError":ReferenceError, =
"SyntaxError":SyntaxError, "TypeError":TypeError, "URIError":URIError };
dwr.engine._getObjectClassName =3D function(obj) {
  // Try to find the classname by stringifying the object's constructor
  // and extract  from "function ".
  if (obj && obj.constructor && obj.constructor.toString)
  {
    var str =3D obj.constructor.toString();
    var regexpmatch =3D str.match(/function\s+(\w+)/);
    if (regexpmatch && regexpmatch.length =3D=3D 2) {
      return regexpmatch[1];
    }
  }

  // Now manually test against the core Error classes, as these in some=20
  // browsers successfully match to the wrong class in the=20
  // Object.toString() test we will do later
  if (obj && obj.constructor) {
    for (var errorname in dwr.engine._errorClasses) {
      if (obj.constructor =3D=3D dwr.engine._errorClasses[errorname]) =
return errorname;
    }
  }

  // Try to find the classname by calling Object.toString() on the =
object
  // and extracting  from "[object ]"
  if (obj) {
    var str =3D Object.prototype.toString.call(obj);
    var regexpmatch =3D str.match(/\[object\s+(\w+)/);
    if (regexpmatch && regexpmatch.length=3D=3D2) {
      return regexpmatch[1];
    }
  }

  // Supplied argument was probably not an object, but what is better?
  return "Object";
};

/** @private Marshall an object */
dwr.engine._serializeXml =3D function(batch, referto, data, name) {
  var ref =3D dwr.engine._lookup(referto, data, name);
  if (ref) return ref;

  var output;
  if (window.XMLSerializer) output =3D new =
XMLSerializer().serializeToString(data);
  else if (data.toXml) output =3D data.toXml;
  else output =3D data.innerHTML;

  return "XML:" + encodeURIComponent(output);
};

/** @private Marshall an array */
dwr.engine._serializeArray =3D function(batch, referto, data, name) {
  var ref =3D dwr.engine._lookup(referto, data, name);
  if (ref) return ref;

  var reply =3D "Array:[";
  for (var i =3D 0; i < data.length; i++) {
    if (i !=3D 0) reply +=3D ",";
    batch.paramCount++;
    var childName =3D "c" + dwr.engine._batch.map.callCount + "-e" + =
batch.paramCount;
    dwr.engine._serializeAll(batch, referto, data[i], childName);
    reply +=3D "reference:";
    reply +=3D childName;
  }
  reply +=3D "]";

  return reply;
};

/** @private Convert an XML string into a DOM object. */
dwr.engine._unserializeDocument =3D function(xml) {
  var dom;
  if (window.DOMParser) {
    var parser =3D new DOMParser();
    dom =3D parser.parseFromString(xml, "text/xml");
    if (!dom.documentElement || dom.documentElement.tagName =3D=3D =
"parsererror") {
      var message =3D dom.documentElement.firstChild.data;
      message +=3D "\n" + =
dom.documentElement.firstChild.nextSibling.firstChild.data;
      throw message;
    }
    return dom;
  }
  else if (window.ActiveXObject) {
    dom =3D dwr.engine._newActiveXObject(dwr.engine._DOMDocument);
    dom.loadXML(xml); // What happens on parse fail with IE?
    return dom;
  }
  else {
    var div =3D document.createElement("div");
    div.innerHTML =3D xml;
    return div;
  }
};

/** @param axarray An array of strings to attempt to create ActiveX =
objects from */
dwr.engine._newActiveXObject =3D function(axarray) {
  var returnValue; =20
  for (var i =3D 0; i < axarray.length; i++) {
    try {
      returnValue =3D new ActiveXObject(axarray[i]);
      break;
    }
    catch (ex) { /* ignore */ }
  }
  return returnValue;
};

/** @private Used internally when some message needs to get to the =
programmer */
dwr.engine._debug =3D function(message, stacktrace) {
  var written =3D false;
  try {
    if (window.console) {
      if (stacktrace && window.console.trace) window.console.trace();
      window.console.log(message);
      written =3D true;
    }
    else if (window.opera && window.opera.postError) {
      window.opera.postError(message);
      written =3D true;
    }
  }
  catch (ex) { /* ignore */ }

  if (!written) {
    var debug =3D document.getElementById("dwr-debug");
    if (debug) {
      var contents =3D message + "
" + debug.innerHTML;
      if (contents.length > 2048) contents =3D contents.substring(0, =
2048);
      debug.innerHTML =3D contents;
    }
  }
};


------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/ajax/ajaxUtil.js

/*
 * Copyright 2005 Joe Walker
 *
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at
 *
 *     http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or =
implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
 */

/**
 * Declare an object to which we can add real functions.
 */
if (dwr =3D=3D null) var dwr =3D {};
if (dwr.util =3D=3D null) dwr.util =3D {};
if (DWRUtil =3D=3D null) var DWRUtil =3D dwr.util;

/** @private The flag we use to decide if we should escape html */
dwr.util._escapeHtml =3D true;

/**
 * Set the global escapeHtml flag
 */
dwr.util.setEscapeHtml =3D function(escapeHtml) {
  dwr.util._escapeHtml =3D escapeHtml;
};

/** @private Work out from an options list and global settings if we =
should be esccaping */
dwr.util._shouldEscapeHtml =3D function(options) {
  if (options && options.escapeHtml !=3D null) {
    return options.escapeHtml;
  }
  return dwr.util._escapeHtml;
};

/**
 * Return a string with &, <, >, ' and " replaced with their entities
 * @see TODO
 */
dwr.util.escapeHtml =3D function(original) {
  var div =3D document.createElement('div');
  var text =3D document.createTextNode(original);
  div.appendChild(text);
  return div.innerHTML;
};

/**
 * Replace common XML entities with characters (see =
dwr.util.escapeHtml())
 * @see TODO
 */
dwr.util.unescapeHtml =3D function(original) {
  var div =3D document.createElement('div');
  div.innerHTML =3D original.replace(/<\/?[^>]+>/gi, '');
  return div.childNodes[0] ? div.childNodes[0].nodeValue : '';
};

/**
 * Replace characters dangerous for XSS reasons with visually similar =
characters
 * @see TODO
 */
dwr.util.replaceXmlCharacters =3D function(original) {
  original =3D original.replace("&", "+");
  original =3D original.replace("<", "\u2039");
  original =3D original.replace(">", "\u203A");
  original =3D original.replace("\'", "\u2018");
  original =3D original.replace("\"", "\u201C");
  return original;
};

/**
 * Return true iff the input string contains any XSS dangerous =
characters
 * @see TODO
 */
dwr.util.containsXssRiskyCharacters =3D function(original) {
  return (original.indexOf('&') !=3D -1
    || original.indexOf('<') !=3D -1
    || original.indexOf('>') !=3D -1
    || original.indexOf('\'') !=3D -1
    || original.indexOf('\"') !=3D -1);
};

/**
 * Enables you to react to return being pressed in an input
 * @see http://getahead.org/dwr/browser/util/selectrange
 */
dwr.util.onReturn =3D function(event, action) {
  if (!event) event =3D window.event;
  if (event && event.keyCode && event.keyCode =3D=3D 13) action();
};

/**
 * Select a specific range in a text box. Useful for 'google suggest' =
type functions.
 * @see http://getahead.org/dwr/browser/util/selectrange
 */
dwr.util.selectRange =3D function(ele, start, end) {
  ele =3D dwr.util._getElementById(ele, "selectRange()");
  if (ele =3D=3D null) return;
  if (ele.setSelectionRange) {
    ele.setSelectionRange(start, end);
  }
  else if (ele.createTextRange) {
    var range =3D ele.createTextRange();
    range.moveStart("character", start);
    range.moveEnd("character", end - ele.value.length);
    range.select();
  }
  ele.focus();
};

/**
 * Find the element in the current HTML document with the given id or =
ids
 * @see http://getahead.org/dwr/browser/util/$
 */
if (document.getElementById) {
  dwr.util.byId =3D function() {
    var elements =3D new Array();
    for (var i =3D 0; i < arguments.length; i++) {
      var element =3D arguments[i];
      if (typeof element =3D=3D 'string') {
        element =3D document.getElementById(element);
      }
      if (arguments.length =3D=3D 1) {
        return element;
      }
      elements.push(element);
    }
    return elements;
  };
}
else if (document.all) {
  dwr.util.byId =3D function() {
    var elements =3D new Array();
    for (var i =3D 0; i < arguments.length; i++) {
      var element =3D arguments[i];
      if (typeof element =3D=3D 'string') {
        element =3D document.all[element];
      }
      if (arguments.length =3D=3D 1) {
        return element;
      }
      elements.push(element);
    }
    return elements;
  };
}

/**
 * Alias $ to dwr.util.byId
 * @see http://getahead.org/dwr/browser/util/$
 */
var $;
if (!$) {
  $ =3D dwr.util.byId;
}

/**
 * This function pretty-prints simple data or whole object graphs, f ex =
as an aid in debugging.
 * @see http://getahead.org/dwr/browser/util/todescriptivestring
 */
dwr.util.toDescriptiveString =3D function(data, showLevels, options) {
  if (showLevels =3D=3D=3D undefined) showLevels =3D 1;
  var opt =3D {};
  if (dwr.util._isObject(options)) opt =3D options;
  var defaultoptions =3D {
    escapeHtml:false,
    baseIndent: "",
    childIndent: "\u00A0\u00A0",
    lineTerminator: "\n",
    oneLineMaxItems: 5,
    shortStringMaxLength: 13,
    propertyNameMaxLength: 30=20
  };
  for (var p in defaultoptions) {
    if (!(p in opt)) {
      opt[p] =3D defaultoptions[p];
    }
  }

  var skipDomProperties =3D {
    document:true, ownerDocument:true,
    all:true,
    parentElement:true, parentNode:true, offsetParent:true,
    children:true, firstChild:true, lastChild:true,
    previousSibling:true, nextSibling:true,
    innerHTML:true, outerHTML:true,
    innerText:true, outerText:true, textContent:true,
    attributes:true,
    style:true, currentStyle:true, runtimeStyle:true,
    parentTextEdit:true
  };
 =20
  function recursive(data, showLevels, indentDepth, options) {
    var reply =3D "";
    try {
      // string
      if (typeof data =3D=3D "string") {
        var str =3D data;
        if (showLevels =3D=3D 0 && str.length > =
options.shortStringMaxLength)
          str =3D str.substring(0, options.shortStringMaxLength-3) + =
"...";
        if (options.escapeHtml) {
          // Do the escape separately for every line as escapeHtml() on =
some=20
          // browsers (IE) will strip line breaks and we want to =
preserve them
          var lines =3D str.split("\n");
          for (var i =3D 0; i < lines.length; i++) lines[i] =3D =
dwr.util.escapeHtml(lines[i]);
          str =3D lines.join("\n");
        }
        if (showLevels =3D=3D 0) { // Short format
          str =3D str.replace(/\n|\r|\t/g, function(ch) {
            switch (ch) {
              case "\n": return "\\n";
              case "\r": return "";
              case "\t": return "\\t";
            }
          });
        }
        else { // Long format
          str =3D str.replace(/\n|\r|\t/g, function(ch) {
            switch (ch) {
              case "\n": return options.lineTerminator + =
indent(indentDepth+1, options);
              case "\r": return "";
              case "\t": return "\\t";
            }
          });
        }
        reply =3D '"' + str + '"';
      }
     =20
      // function
      else if (typeof data =3D=3D "function") {
        reply =3D "function";
      }
   =20
      // Array
      else if (dwr.util._isArray(data)) {
        if (showLevels =3D=3D 0) { // Short format (don't show items)
          if (data.length > 0)
            reply =3D "[...]";
          else
            reply =3D "[]";
        }
        else { // Long format (show items)
          var strarr =3D [];
          strarr.push("[");
          var count =3D 0;
          for (var i =3D 0; i < data.length; i++) {
            if (! (i in data)) continue;
            var itemvalue =3D data[i];
            if (count > 0) strarr.push(", ");
            if (showLevels =3D=3D 1) { // One-line format
              if (count =3D=3D options.oneLineMaxItems) {
                strarr.push("...");
                break;
              }
            }
            else { // Multi-line format
              strarr.push(options.lineTerminator + indent(indentDepth+1, =
options));
            }
            if (i !=3D count) {
              strarr.push(i);
              strarr.push(":");
            }
            strarr.push(recursive(itemvalue, showLevels-1, =
indentDepth+1, options));
            count++;
          }
          if (showLevels > 1) strarr.push(options.lineTerminator + =
indent(indentDepth, options));
          strarr.push("]");
          reply =3D strarr.join("");
        }
      }
     =20
      // Objects except Date
      else if (dwr.util._isObject(data) && !dwr.util._isDate(data)) {
        if (showLevels =3D=3D 0) { // Short format (don't show =
properties)
          reply =3D dwr.util._detailedTypeOf(data);
        }
        else { // Long format (show properties)
          var strarr =3D [];
          if (dwr.util._detailedTypeOf(data) !=3D "Object") {
            strarr.push(dwr.util._detailedTypeOf(data));
            if (typeof data.valueOf() !=3D "object") {
              strarr.push(":");
              strarr.push(recursive(data.valueOf(), 1, indentDepth, =
options));
            }
            strarr.push(" ");
          }
          strarr.push("{");
          var isDomObject =3D dwr.util._isHTMLElement(data);=20
          var count =3D 0;
          for (var prop in data) {
            var propvalue =3D data[prop];
            if (isDomObject) {
              if (!propvalue) continue;
              if (typeof propvalue =3D=3D "function") continue;
              if (skipDomProperties[prop]) continue;
              if (prop.toUpperCase() =3D=3D prop) continue;
            }
            if (count > 0) strarr.push(", ");
            if (showLevels =3D=3D 1) { // One-line format
              if (count =3D=3D options.oneLineMaxItems) {
                strarr.push("...");
                break;
              }
            }
            else { // Multi-line format
              strarr.push(options.lineTerminator + indent(indentDepth+1, =
options));
            }
            strarr.push(prop.length > options.propertyNameMaxLength ? =
prop.substring(0, options.propertyNameMaxLength-3) + "..." : prop);
            strarr.push(":");
            strarr.push(recursive(propvalue, showLevels-1, =
indentDepth+1, options));
            count++;
          }
          if (showLevels > 1 && count > 0) =
strarr.push(options.lineTerminator + indent(indentDepth, options));
          strarr.push("}");
          reply =3D strarr.join("");
        }
      }
 =20
      // undefined, null, number, boolean, Date
      else {
        reply =3D "" + data;
      }
 =20
      return reply;
    }
    catch(err) {
      return (err.message ? err.message : ""+err);
    }
  }

  function indent(count, options) {
    var strarr =3D [];
    strarr.push(options.baseIndent);
    for (var i=3D0; i=3D 1) ele =3D nodes.item(0);
  }

  if (ele =3D=3D null) {
    dwr.util._debug("setValue() can't find an element with id/name: " + =
orig + ".");
    return;
  }

  // All paths now lead to some update so we highlight a change
  dwr.util.highlight(ele, options);

  if (dwr.util._isHTMLElement(ele, "select")) {
    if (ele.type =3D=3D "select-multiple" && dwr.util._isArray(val)) =
dwr.util._selectListItems(ele, val);
    else dwr.util._selectListItem(ele, val);
    return;
  }

  if (dwr.util._isHTMLElement(ele, "input")) {
    if (ele.type =3D=3D "radio" || ele.type =3D=3D "checkbox") {
      if (nodes && nodes.length >=3D 1) {
        for (var i =3D 0; i < nodes.length; i++) {
          var node =3D nodes.item(i);
          if (node.type !=3D ele.type) continue;
          if (dwr.util._isArray(val)) {
            node.checked =3D false;
            for (var j =3D 0; j < val.length; j++)
              if (val[j] =3D=3D node.value) node.checked =3D true;
          }
          else {
            node.checked =3D (node.value =3D=3D val);
          }
        }
      }
      else {
        ele.checked =3D (val =3D=3D true);
      }
    }
    else ele.value =3D val;

    return;
  }

  if (dwr.util._isHTMLElement(ele, "textarea")) {
    ele.value =3D val;
    return;
  }

  // If the value to be set is a DOM object then we try importing the =
node
  // rather than serializing it out
  if (val.nodeType) {
    if (val.nodeType =3D=3D 9 /*Node.DOCUMENT_NODE*/) val =3D =
val.documentElement;
    val =3D dwr.util._importNode(ele.ownerDocument, val, true);
    ele.appendChild(val);
    return;
  }

  // Fall back to innerHTML and friends
  if (dwr.util._shouldEscapeHtml(options) && typeof(val) =3D=3D =
"string") {
    if (ele.textContent) ele.textContent =3D val;
    else if (ele.innerText) ele.innerText =3D val;
    else ele.innerHTML =3D dwr.util.escapeHtml(val);
  }
  else {
    ele.innerHTML =3D val;
  }
};

/**
 * @private Find multiple items in a select list and select them. Used =
by setValue()
 * @param ele The select list item
 * @param val The array of values to select
 */
dwr.util._selectListItems =3D function(ele, val) {
  // We deal with select list elements by selecting the matching option
  // Begin by searching through the values
  var found  =3D false;
  var i;
  var j;
  for (i =3D 0; i < ele.options.length; i++) {
    ele.options[i].selected =3D false;
    for (j =3D 0; j < val.length; j++) {
      if (ele.options[i].value =3D=3D val[j]) {
        ele.options[i].selected =3D true;
      }
    }
  }
  // If that fails then try searching through the visible text
  if (found) return;

  for (i =3D 0; i < ele.options.length; i++) {
    for (j =3D 0; j < val.length; j++) {
      if (ele.options[i].text =3D=3D val[j]) {
        ele.options[i].selected =3D true;
      }
    }
  }
};

/**
 * @private Find an item in a select list and select it. Used by =
setValue()
 * @param ele The select list item
 * @param val The value to select
 */
dwr.util._selectListItem =3D function(ele, val) {
  // We deal with select list elements by selecting the matching option
  // Begin by searching through the values
  var found =3D false;
  var i;
  for (i =3D 0; i < ele.options.length; i++) {
    if (ele.options[i].value =3D=3D val) {
      ele.options[i].selected =3D true;
      found =3D true;
    }
    else {
      ele.options[i].selected =3D false;
    }
  }

  // If that fails then try searching through the visible text
  if (found) return;

  for (i =3D 0; i < ele.options.length; i++) {
    ele.options[i].selected =3D (ele.options[i].text =3D=3D val);
  }
};

/**
 * Read the current value for a given HTML element.
 * @see http://getahead.org/dwr/browser/util/getvalue
 */
dwr.util.getValue =3D function(ele, options) {
  if (options =3D=3D null) options =3D {};
  var orig =3D ele;
  if (typeof ele =3D=3D "string") {
    ele =3D dwr.util.byId(ele);
    // We can work with names and need to sometimes for radio buttons, =
and IE has
    // an annoying bug where getElementById() returns an element based =
on name if
    // it doesn't find it by id. Here we don't want to do that, so:
    if (ele && ele.id !=3D orig) ele =3D null;
  }
  var nodes =3D null;
  if (ele =3D=3D null) {
    // Now it is time to look by name
    nodes =3D document.getElementsByName(orig);
    if (nodes.length >=3D 1) ele =3D nodes.item(0);
  }
  if (ele =3D=3D null) {
    dwr.util._debug("getValue() can't find an element with id/name: " + =
orig + ".");
    return "";
  }

  if (dwr.util._isHTMLElement(ele, "select")) {
    // Using "type" property instead of "multiple" as "type" is an =
official=20
    // client-side property since JS 1.1
    if (ele.type =3D=3D "select-multiple") {
      var reply =3D new Array();
      for (var i =3D 0; i < ele.options.length; i++) {
        var item =3D ele.options[i];
        if (item.selected) {
          var valueAttr =3D item.getAttributeNode("value");
          if (valueAttr && valueAttr.specified) {
            reply.push(item.value);
          }
          else {
            reply.push(item.text);
          }
        }
      }
      return reply;
    }
    else {
      var sel =3D ele.selectedIndex;
      if (sel !=3D -1) {
        var item =3D ele.options[sel];
        var valueAttr =3D item.getAttributeNode("value");
        if (valueAttr && valueAttr.specified) {
          return item.value;
        }
        return item.text;
      }
      else {
        return "";
      }
    }
  }

  if (dwr.util._isHTMLElement(ele, "input")) {
    if (ele.type =3D=3D "radio") {
      if (nodes && nodes.length >=3D 1) {
        for (var i =3D 0; i < nodes.length; i++) {
          var node =3D nodes.item(i);
          if (node.type =3D=3D ele.type) {
            if (node.checked) return node.value;
          }
        }
      }
      return ele.checked;
    }
    if (ele.type =3D=3D "checkbox") {
      if (nodes && nodes.length >=3D 1) {
        var reply =3D [];
        for (var i =3D 0; i < nodes.length; i++) {
          var node =3D nodes.item(i);
          if (node.type =3D=3D ele.type) {
            if (node.checked) reply.push(node.value);
          }
        }
        return reply;
      }
      return ele.checked;
    }
    return ele.value;
  }

  if (dwr.util._isHTMLElement(ele, "textarea")) {
    return ele.value;
  }

  if (dwr.util._shouldEscapeHtml(options)) {
    if (ele.textContent) return ele.textContent;
    else if (ele.innerText) return ele.innerText;
  }
  return ele.innerHTML;
};

/**
 * getText() is like getValue() except that it reads the text (and not =
the value) from select elements
 * @see http://getahead.org/dwr/browser/util/gettext
 */
dwr.util.getText =3D function(ele) {
  ele =3D dwr.util._getElementById(ele, "getText()");
  if (ele =3D=3D null) return null;
  if (!dwr.util._isHTMLElement(ele, "select")) {
    dwr.util._debug("getText() can only be used with select elements. =
Attempt to use: " + dwr.util._detailedTypeOf(ele) + " from  id: " + orig =
+ ".");
    return "";
  }

  // This is a bit of a scam because it assumes single select
  // but I'm not sure how we should treat multi-select.
  var sel =3D ele.selectedIndex;
  if (sel !=3D -1) {
    return ele.options[sel].text;
  }
  else {
    return "";
  }
};

/**
 * Given a map, or a recursive structure consisting of arrays and maps, =
call=20
 * setValue() for all leaf entries and use intermediate levels to form =
nested
 * element ids.
 * @see http://getahead.org/dwr/browser/util/setvalues
 */
dwr.util.setValues =3D function(data, options) {
  var prefix =3D "";
  if (options && options.prefix) prefix =3D options.prefix;
  if (options && options.idPrefix) prefix =3D options.idPrefix;
  dwr.util._setValuesRecursive(data, prefix);
};

/**
 * @private Recursive helper for setValues()
 */
dwr.util._setValuesRecursive =3D function(data, idpath) {
  // Array containing objects -> add "[n]" to prefix and make recursive =
call
  // for each item object
  if (dwr.util._isArray(data) && data.length > 0 && =
dwr.util._isObject(data[0])) {
    for (var i =3D 0; i < data.length; i++) {
      dwr.util._setValuesRecursive(data[i], idpath+"["+i+"]");
    }
  }
  // Object (not array) -> handle nested object properties
  else if (dwr.util._isObject(data) && !dwr.util._isArray(data)) {
    for (var prop in data) {
      var subidpath =3D idpath ? idpath+"."+prop : prop;
      // Object (not array), or array containing objects -> call =
ourselves recursively
      if (dwr.util._isObject(data[prop]) && =
!dwr.util._isArray(data[prop])=20
          || dwr.util._isArray(data[prop]) && data[prop].length > 0 && =
dwr.util._isObject(data[prop][0])) {
        dwr.util._setValuesRecursive(data[prop], subidpath);
      }
      // Functions -> skip
      else if (typeof data[prop] =3D=3D "function") {
        // NOP
      }
      // Only simple values left (or array of simple values, or empty =
array)
      // -> call setValue()
      else {
        // Are there any elements with that id or name
        if (dwr.util.byId(subidpath) !=3D null || =
document.getElementsByName(subidpath).length >=3D 1) {
          dwr.util.setValue(subidpath, data[prop]);
        }
      }
    }
  }
};

/**
 * Given a map, or a recursive structure consisting of arrays and maps, =
call=20
 * getValue() for all leaf entries and use intermediate levels to form =
nested
 * element ids.
 * Given a string or element that refers to a form, create an object =
from the=20
 * elements of the form.
 * @see http://getahead.org/dwr/browser/util/getvalues
 */
dwr.util.getValues =3D function(data, options) {
  if (typeof data =3D=3D "string" || dwr.util._isHTMLElement(data)) {
    return dwr.util.getFormValues(data);
  }
  else {
    var prefix =3D "";
    if (options !=3D null && options.prefix) prefix =3D options.prefix;
    if (options !=3D null && options.idPrefix) prefix =3D =
options.idPrefix;
    dwr.util._getValuesRecursive(data, prefix);
    return data;
  }
};

/**
 * Given a string or element that refers to a form, create an object =
from the=20
 * elements of the form.
 * @see http://getahead.org/dwr/browser/util/getvalues
 */
dwr.util.getFormValues =3D function(eleOrNameOrId) {
  var ele =3D null;
  if (typeof eleOrNameOrId =3D=3D "string") {
    ele =3D document.forms[eleOrNameOrId];
    if (ele =3D=3D null) ele =3D dwr.util.byId(eleOrNameOrId);
  }
  else if (dwr.util._isHTMLElement(eleOrNameOrId)) {
    ele =3D eleOrNameOrId;
  }
  if (ele !=3D null) {
    if (ele.elements =3D=3D null) {
      alert("getFormValues() requires an object or reference to a form =
element.");
      return null;
    }
    var reply =3D {};
    var name;
    var value;
    for (var i =3D 0; i < ele.elements.length; i++) {
      if (ele[i].type in {button:0,submit:0,reset:0,image:0,file:0}) =
continue;
      if (ele[i].name) {
        name =3D ele[i].name;
        value =3D dwr.util.getValue(name);
      }
      else {
        if (ele[i].id) name =3D ele[i].id;
        else name =3D "element" + i;
        value =3D dwr.util.getValue(ele[i]);
      }
      reply[name] =3D value;
    }
    return reply;
  }
};

/**
 * @private Recursive helper for getValues().
 */
dwr.util._getValuesRecursive =3D function(data, idpath) {
  // Array containing objects -> add "[n]" to idpath and make recursive =
call
  // for each item object
  if (dwr.util._isArray(data) && data.length > 0 && =
dwr.util._isObject(data[0])) {
    for (var i =3D 0; i < data.length; i++) {
      dwr.util._getValuesRecursive(data[i], idpath+"["+i+"]");
    }
  }
  // Object (not array) -> handle nested object properties
  else if (dwr.util._isObject(data) && !dwr.util._isArray(data)) {
    for (var prop in data) {
      var subidpath =3D idpath ? idpath+"."+prop : prop;
      // Object, or array containing objects -> call ourselves =
recursively
      if (dwr.util._isObject(data[prop]) && =
!dwr.util._isArray(data[prop])
          || dwr.util._isArray(data[prop]) && data[prop].length > 0 && =
dwr.util._isObject(data[prop][0])) {
        dwr.util._getValuesRecursive(data[prop], subidpath);
      }
      // Functions -> skip
      else if (typeof data[prop] =3D=3D "function") {
        // NOP
      }
      // Only simple values left (or array of simple values, or empty =
array)
      // -> call getValue()
      else {
        // Are there any elements with that id or name
        if (dwr.util.byId(subidpath) !=3D null || =
document.getElementsByName(subidpath).length >=3D 1) {
          data[prop] =3D dwr.util.getValue(subidpath);
        }
      }
    }
  }
};

/**
 * Add options to a list from an array or map.
 * @see http://getahead.org/dwr/browser/lists
 */
dwr.util.addOptions =3D function(ele, data/*, options*/) {
  ele =3D dwr.util._getElementById(ele, "addOptions()");
  if (ele =3D=3D null) return;
  var useOptions =3D dwr.util._isHTMLElement(ele, "select");
  var useLi =3D dwr.util._isHTMLElement(ele, ["ul", "ol"]);
  if (!useOptions && !useLi) {
    dwr.util._debug("addOptions() can only be used with select/ul/ol =
elements. Attempt to use: " + dwr.util._detailedTypeOf(ele));
    return;
  }
  if (data =3D=3D null) return;
 =20
  var argcount =3D arguments.length;
  var options =3D {};
  var lastarg =3D arguments[argcount - 1];=20
  if (argcount > 2 && dwr.util._isObject(lastarg)) {
    options =3D lastarg;
    argcount--;
  }
  var arg3 =3D null; if (argcount >=3D 3) arg3 =3D arguments[2];
  var arg4 =3D null; if (argcount >=3D 4) arg4 =3D arguments[3];
  if (!options.optionCreator && useOptions) options.optionCreator =3D =
dwr.util._defaultOptionCreator;
  if (!options.optionCreator && useLi) options.optionCreator =3D =
dwr.util._defaultListItemCreator;

  var text, value, li;
  if (dwr.util._isArray(data)) {
    // Loop through the data that we do have
    for (var i =3D 0; i < data.length; i++) {
      options.data =3D data[i];
      options.text =3D null;
      options.value =3D null;
      if (useOptions) {
        if (arg3 !=3D null) {
          if (arg4 !=3D null) {
            options.text =3D dwr.util._getValueFrom(data[i], arg4);
            options.value =3D dwr.util._getValueFrom(data[i], arg3);
          }
          else options.text =3D options.value =3D =
dwr.util._getValueFrom(data[i], arg3);
        }
        else options.text =3D options.value =3D =
dwr.util._getValueFrom(data[i]);

        if (options.text !=3D null || options.value) {
          var opt =3D options.optionCreator(options);
          opt.text =3D options.text;
          opt.value =3D options.value;
          ele.options[ele.options.length] =3D opt;
        }
      }
      else {
        options.value =3D dwr.util._getValueFrom(data[i], arg3);
        if (options.value !=3D null) {
          li =3D options.optionCreator(options);
          if (dwr.util._shouldEscapeHtml(options)) {
            options.value =3D dwr.util.escapeHtml(options.value);
          }
          li.innerHTML =3D options.value;
          ele.appendChild(li);
        }
      }
    }
  }
  else if (arg4 !=3D null) {
    if (!useOptions) {
      alert("dwr.util.addOptions can only create select lists from =
objects.");
      return;
    }
    for (var prop in data) {
      options.data =3D data[prop];
      options.value =3D dwr.util._getValueFrom(data[prop], arg3);
      options.text =3D dwr.util._getValueFrom(data[prop], arg4);

      if (options.text !=3D null || options.value) {
        var opt =3D options.optionCreator(options);
        opt.text =3D options.text;
        opt.value =3D options.value;
        ele.options[ele.options.length] =3D opt;
      }
    }
  }
  else {
    if (!useOptions) {
      dwr.util._debug("dwr.util.addOptions can only create select lists =
from objects.");
      return;
    }
    for (var prop in data) {
      if (typeof data[prop] =3D=3D "function") continue;
      options.data =3D data[prop];
      if (!arg3) {
        options.value =3D prop;
        options.text =3D data[prop];
      }
      else {
        options.value =3D data[prop];
        options.text =3D prop;
      }
      if (options.text !=3D null || options.value) {
        var opt =3D options.optionCreator(options);
        opt.text =3D options.text;
        opt.value =3D options.value;
        ele.options[ele.options.length] =3D opt;
      }
    }
  }

  // All error routes through this function result in a return, so =
highlight now
  dwr.util.highlight(ele, options);=20
};

/**
 * @private Get the data from an array function for dwr.util.addOptions
 */
dwr.util._getValueFrom =3D function(data, method) {
  if (method =3D=3D null) return data;
  else if (typeof method =3D=3D 'function') return method(data);
  else return data[method];
};

/**
 * @private Default option creation function
 */
dwr.util._defaultOptionCreator =3D function(options) {
  return new Option();
};

/**
 * @private Default list item creation function
 */
dwr.util._defaultListItemCreator =3D function(options) {
  return document.createElement("li");
};

/**
 * Remove all the options from a select list (specified by id)
 * @see http://getahead.org/dwr/browser/lists
 */
dwr.util.removeAllOptions =3D function(ele) {
  ele =3D dwr.util._getElementById(ele, "removeAllOptions()");
  if (ele =3D=3D null) return;
  var useOptions =3D dwr.util._isHTMLElement(ele, "select");
  var useLi =3D dwr.util._isHTMLElement(ele, ["ul", "ol"]);
  if (!useOptions && !useLi) {
    dwr.util._debug("removeAllOptions() can only be used with select, ol =
and ul elements. Attempt to use: " + dwr.util._detailedTypeOf(ele));
    return;
  }
  if (useOptions) {
    ele.options.length =3D 0;
  }
  else {
    while (ele.childNodes.length > 0) {
      ele.removeChild(ele.firstChild);
    }
  }
};

/**
 * Create rows inside a the table, tbody, thead or tfoot element (given =
by id).
 * @see http://getahead.org/dwr/browser/tables
 */
dwr.util.addRows =3D function(ele, data, cellFuncs, options) {
  ele =3D dwr.util._getElementById(ele, "addRows()");
  if (ele =3D=3D null) return;
  if (!dwr.util._isHTMLElement(ele, ["table", "tbody", "thead", =
"tfoot"])) {
    dwr.util._debug("addRows() can only be used with table, tbody, thead =
and tfoot elements. Attempt to use: " + dwr.util._detailedTypeOf(ele));
    return;
  }
  if (!options) options =3D {};
  if (!options.rowCreator) options.rowCreator =3D =
dwr.util._defaultRowCreator;
  if (!options.cellCreator) options.cellCreator =3D =
dwr.util._defaultCellCreator;
  var tr, rowNum;
  if (dwr.util._isArray(data)) {
    for (rowNum =3D 0; rowNum < data.length; rowNum++) {
      options.rowData =3D data[rowNum];
      options.rowIndex =3D rowNum;
      options.rowNum =3D rowNum;
      options.data =3D null;
      options.cellNum =3D -1;
      tr =3D dwr.util._addRowInner(cellFuncs, options);
      if (tr !=3D null) ele.appendChild(tr);
    }
  }
  else if (typeof data =3D=3D "object") {
    rowNum =3D 0;
    for (var rowIndex in data) {
      options.rowData =3D data[rowIndex];
      options.rowIndex =3D rowIndex;
      options.rowNum =3D rowNum;
      options.data =3D null;
      options.cellNum =3D -1;
      tr =3D dwr.util._addRowInner(cellFuncs, options);
      if (tr !=3D null) ele.appendChild(tr);
      rowNum++;
    }
  }

  dwr.util.highlight(ele, options);
};

/**
 * @private Internal function to draw a single row of a table.
 */
dwr.util._addRowInner =3D function(cellFuncs, options) {
  var tr =3D options.rowCreator(options);
  if (tr =3D=3D null) return null;
  for (var cellNum =3D 0; cellNum < cellFuncs.length; cellNum++) {
    var func =3D cellFuncs[cellNum];
    if (typeof func =3D=3D 'function') options.data =3D =
func(options.rowData, options);
    else options.data =3D func || "";
    options.cellNum =3D cellNum;
    var td =3D options.cellCreator(options);
    if (td !=3D null) {
      if (options.data !=3D null) {
        if (dwr.util._isHTMLElement(options.data)) =
td.appendChild(options.data);
        else {
          if (dwr.util._shouldEscapeHtml(options) && =
typeof(options.data) =3D=3D "string") {
            td.innerHTML =3D dwr.util.escapeHtml(options.data);
          }
          else {
            td.innerHTML =3D options.data;
          }
        }
      }
      tr.appendChild(td);
    }
  }
  return tr;
};

/**
 * @private Default row creation function
 */
dwr.util._defaultRowCreator =3D function(options) {
  return document.createElement("tr");
};

/**
 * @private Default cell creation function
 */
dwr.util._defaultCellCreator =3D function(options) {
  return document.createElement("td");
};

/**
 * Remove all the children of a given node.
 * @see http://getahead.org/dwr/browser/tables
 */
dwr.util.removeAllRows =3D function(ele, options) {
  ele =3D dwr.util._getElementById(ele, "removeAllRows()");
  if (ele =3D=3D null) return;
  if (!options) options =3D {};
  if (!options.filter) options.filter =3D function() { return true; };
  if (!dwr.util._isHTMLElement(ele, ["table", "tbody", "thead", =
"tfoot"])) {
    dwr.util._debug("removeAllRows() can only be used with table, tbody, =
thead and tfoot elements. Attempt to use: " + =
dwr.util._detailedTypeOf(ele));
    return;
  }
  var child =3D ele.firstChild;
  var next;
  while (child !=3D null) {
    next =3D child.nextSibling;
    if (options.filter(child)) {
      ele.removeChild(child);
    }
    child =3D next;
  }
};

/**
 * dwr.util.byId(ele).className =3D "X", that we can call from Java =
easily.
 */
dwr.util.setClassName =3D function(ele, className) {
  ele =3D dwr.util._getElementById(ele, "setClassName()");
  if (ele =3D=3D null) return;
  ele.className =3D className;
};

/**
 * dwr.util.byId(ele).className +=3D "X", that we can call from Java =
easily.
 */
dwr.util.addClassName =3D function(ele, className) {
  ele =3D dwr.util._getElementById(ele, "addClassName()");
  if (ele =3D=3D null) return;
  ele.className +=3D " " + className;
};

/**
 * dwr.util.byId(ele).className -=3D "X", that we can call from Java =
easily
 * From code originally by Gavin Kistner
 */
dwr.util.removeClassName =3D function(ele, className) {
  ele =3D dwr.util._getElementById(ele, "removeClassName()");
  if (ele =3D=3D null) return;
  var regex =3D new RegExp("(^|\\s)" + className + "(\\s|$)", 'g');
  ele.className =3D ele.className.replace(regex, '');
};

/**
 * dwr.util.byId(ele).className |=3D "X", that we can call from Java =
easily.
 */
dwr.util.toggleClassName =3D function(ele, className) {
  ele =3D dwr.util._getElementById(ele, "toggleClassName()");
  if (ele =3D=3D null) return;
  var regex =3D new RegExp("(^|\\s)" + className + "(\\s|$)");
  if (regex.test(ele.className)) {
    ele.className =3D ele.className.replace(regex, '');
  }
  else {
    ele.className +=3D " " + className;
  }
};

/**
 * Clone a node and insert it into the document just above the =
'template' node
 * @see http://getahead.org/dwr/???
 */
dwr.util.cloneNode =3D function(ele, options) {
  ele =3D dwr.util._getElementById(ele, "cloneNode()");
  if (ele =3D=3D null) return null;
  if (options =3D=3D null) options =3D {};
  var clone =3D ele.cloneNode(true);
  if (options.idPrefix || options.idSuffix) {
    dwr.util._updateIds(clone, options);
  }
  else {
    dwr.util._removeIds(clone);
  }
  ele.parentNode.insertBefore(clone, ele);
  return clone;
};

/**
 * @private Update all of the ids in an element tree
 */
dwr.util._updateIds =3D function(ele, options) {
  if (options =3D=3D null) options =3D {};
  if (ele.id) {
    ele.setAttribute("id", (options.idPrefix || "") + ele.id + =
(options.idSuffix || ""));
  }
  var children =3D ele.childNodes;
  for (var i =3D 0; i < children.length; i++) {
    var child =3D children.item(i);
    if (child.nodeType =3D=3D 1 /*Node.ELEMENT_NODE*/) {
      dwr.util._updateIds(child, options);
    }
  }
};

/**
 * @private Remove all the Ids from an element
 */
dwr.util._removeIds =3D function(ele) {
  if (ele.id) ele.removeAttribute("id");
  var children =3D ele.childNodes;
  for (var i =3D 0; i < children.length; i++) {
    var child =3D children.item(i);
    if (child.nodeType =3D=3D 1 /*Node.ELEMENT_NODE*/) {
      dwr.util._removeIds(child);
    }
  }
};

/**
 * Clone a template node and its embedded template child nodes according =
to
 * cardinalities (of arrays) in supplied data. =20
 */
dwr.util.cloneNodeForValues =3D function(templateEle, data, options) {
  templateEle =3D dwr.util._getElementById(templateEle, =
"cloneNodeForValues()");
  if (templateEle =3D=3D null) return null;
  if (options =3D=3D null) options =3D {};
  var idpath;
  if (options.idPrefix !=3D null)
    idpath =3D options.idPrefix;
  else
    idpath =3D templateEle.id || "";=20
  return dwr.util._cloneNodeForValuesRecursive(templateEle, data, =
idpath, options);
};

/**
 * @private Recursive helper for cloneNodeForValues().=20
 */
dwr.util._cloneNodeForValuesRecursive =3D function(templateEle, data, =
idpath, options) {
  // Incoming array -> make an id for each item and call clone of the =
template=20
  // for each of them
  if (dwr.util._isArray(data)) {
    var clones =3D [];
    for (var i =3D 0; i < data.length; i++) {
      var item =3D data[i];
      var clone =3D dwr.util._cloneNodeForValuesRecursive(templateEle, =
item, idpath + "[" + i + "]", options);
      clones.push(clone);
    }
    return clones;
  }
  else
  // Incoming object (not array) -> clone the template, add id prefixes, =
add=20
  // clone to DOM, and then recurse into any array properties if they =
contain=20
  // objects and there is a suitable template
  if (dwr.util._isObject(data) && !dwr.util._isArray(data)) {
    var clone =3D templateEle.cloneNode(true);
    if (options.updateCloneStyle && clone.style) {
      for (var propname in options.updateCloneStyle) {
        clone.style[propname] =3D options.updateCloneStyle[propname];
      }
    }
    dwr.util._replaceIds(clone, templateEle.id, idpath);
    templateEle.parentNode.insertBefore(clone, templateEle);
    dwr.util._cloneSubArrays(data, idpath, options);
    return clone;
  }

  // It is an error to end up here so we return nothing
  return null;
};

/**
 * @private Substitute a leading idpath fragment with another idpath for =
all=20
 * element ids tree, and remove ids that don't match the idpath.=20
 */
dwr.util._replaceIds =3D function(ele, oldidpath, newidpath) {
  if (ele.id) {
    var newId =3D null;
    if (ele.id =3D=3D oldidpath) {
      newId =3D newidpath;
    }
    else if (ele.id.length > oldidpath.length) {
      if (ele.id.substr(0, oldidpath.length) =3D=3D oldidpath) {
        var trailingChar =3D ele.id.charAt(oldidpath.length);
        if (trailingChar =3D=3D "." || trailingChar =3D=3D "[") {
          newId =3D newidpath + ele.id.substr(oldidpath.length);
        }
      }
    }
    if (newId) {
      ele.setAttribute("id", newId);
    }
    else {
      ele.removeAttribute("id");
    }
  }
  var children =3D ele.childNodes;
  for (var i =3D 0; i < children.length; i++) {
    var child =3D children.item(i);
    if (child.nodeType =3D=3D 1 /*Node.ELEMENT_NODE*/) {
      dwr.util._replaceIds(child, oldidpath, newidpath);
    }
  }
};

/**
 * @private Finds arrays in supplied data and uses any corresponding =
template=20
 * node to make a clone for each item in the array.=20
 */
dwr.util._cloneSubArrays =3D function(data, idpath, options) {
  for (prop in data) {
    var value =3D data[prop];
    // Look for potential recursive cloning in all array properties
    if (dwr.util._isArray(value)) {
      // Only arrays with objects are interesting for cloning
      if (value.length > 0 && dwr.util._isObject(value[0])) {
        var subTemplateId =3D idpath + "." + prop;
        var subTemplateEle =3D dwr.util.byId(subTemplateId);
        if (subTemplateEle !=3D null) {
          dwr.util._cloneNodeForValuesRecursive(subTemplateEle, value, =
subTemplateId, options);
        }
      }
    }
    // Continue looking for arrays in object properties
    else if (dwr.util._isObject(value)) {
      dwr.util._cloneSubArrays(value, idpath + "." + prop, options);
    }
  }
};

/**
 * @private Helper to turn a string into an element with an error =
message
 */
dwr.util._getElementById =3D function(ele, source) {
  var orig =3D ele;
  ele =3D dwr.util.byId(ele);
  if (ele =3D=3D null) {
    dwr.util._debug(source + " can't find an element with id: " + orig + =
".");
  }
  return ele;
};

/**
 * @private Is the given node an HTML element (optionally of a given =
type)?
 * @param ele The element to test
 * @param nodeName eg "input", "textarea" - check for node name =
(optional)
 *         if nodeName is an array then check all for a match.
 */
dwr.util._isHTMLElement =3D function(ele, nodeName) {
  if (ele =3D=3D null || typeof ele !=3D "object" || ele.nodeName =3D=3D =
null) {
    return false;
  }
  if (nodeName !=3D null) {
    var test =3D ele.nodeName.toLowerCase();
    if (typeof nodeName =3D=3D "string") {
      return test =3D=3D nodeName.toLowerCase();
    }
    if (dwr.util._isArray(nodeName)) {
      var match =3D false;
      for (var i =3D 0; i < nodeName.length && !match; i++) {
        if (test =3D=3D nodeName[i].toLowerCase()) {
          match =3D  true;
        }
      }
      return match;
    }
    dwr.util._debug("dwr.util._isHTMLElement was passed test node name =
that is neither a string or array of strings");
    return false;
  }
  return true;
};

/**
 * @private Like typeOf except that more information for an object is =
returned other than "object"
 */
dwr.util._detailedTypeOf =3D function(x) {
  var reply =3D typeof x;
  if (reply =3D=3D "object") {
    reply =3D Object.prototype.toString.apply(x); // Returns "[object =
class]"
    reply =3D reply.substring(8, reply.length-1);  // Just get the class =
bit
  }
  return reply;
};

/**
 * @private Object detector. Excluding null from objects.
 */
dwr.util._isObject =3D function(data) {
  return (data && typeof data =3D=3D "object");
};

/**
 * @private Array detector. Note: instanceof doesn't work with multiple =
frames.
 */
dwr.util._isArray =3D function(data) {
  return (data && data.join);
};

/**
 * @private Date detector. Note: instanceof doesn't work with multiple =
frames.
 */
dwr.util._isDate =3D function(data) {
  return (data && data.toUTCString) ? true : false;
};

/**
 * @private Used by setValue. Gets around the missing functionallity in =
IE.
 */
dwr.util._importNode =3D function(doc, importedNode, deep) {
  var newNode;

  if (importedNode.nodeType =3D=3D 1 /*Node.ELEMENT_NODE*/) {
    newNode =3D doc.createElement(importedNode.nodeName);

    for (var i =3D 0; i < importedNode.attributes.length; i++) {
      var attr =3D importedNode.attributes[i];
      if (attr.nodeValue !=3D null && attr.nodeValue !=3D '') {
        newNode.setAttribute(attr.name, attr.nodeValue);
      }
    }

    if (typeof importedNode.style !=3D "undefined") {
      newNode.style.cssText =3D importedNode.style.cssText;
    }
  }
  else if (importedNode.nodeType =3D=3D 3 /*Node.TEXT_NODE*/) {
    newNode =3D doc.createTextNode(importedNode.nodeValue);
  }

  if (deep && importedNode.hasChildNodes()) {
    for (i =3D 0; i < importedNode.childNodes.length; i++) {
      newNode.appendChild(dwr.util._importNode(doc, =
importedNode.childNodes[i], true));
    }
  }

  return newNode;
};

/** @private Used internally when some message needs to get to the =
programmer */
dwr.util._debug =3D function(message, stacktrace) {
  var written =3D false;
  try {
    if (window.console) {
      if (stacktrace && window.console.trace) window.console.trace();
      window.console.log(message);
      written =3D true;
    }
    else if (window.opera && window.opera.postError) {
      window.opera.postError(message);
      written =3D true;
    }
  }
  catch (ex) { /* ignore */ }

  if (!written) {
    var debug =3D document.getElementById("dwr-debug");
    if (debug) {
      var contents =3D message + "
" + debug.innerHTML;
      if (contents.length > 2048) contents =3D contents.substring(0, =
2048);
      debug.innerHTML =3D contents;
    }
  }
};


------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/ajax/aotfDwrRenderer.js

function switchTab(articlePii, tabName, is_abstractPage) {
	if (is_abstractPage =3D=3D "true"){
		=
AOTFDwrController.fetchTransformedTabContentForAbstractRequest(articlePii=
, tabName, updateTabContent);
	} else {
		AOTFDwrController.fetchTransformedTabContent(articlePii, tabName, =
updateTabContent);
	}
}

function updateTabContent(str) {
	updatePrimaryTabArea(str);
	insertJavascriptToAllElements();
}

function insertJavascriptToAllElements() {
	if (!isPrimaryTabAreaPopulatedWithReferencesMainTab()) {
		hideauthormenu();
		$("#tempauthfiltdiv").remove();
	}
	if (contextInArticleSelected){
		if(isPrimaryTabAreaPopulatedWithResultsTab()){
			getZoomWidths();
			highlightResultsContext(contextInArticleText);
		}else{
			highlightContext(contextInArticleText);
		}
	}
	if(isPrimaryTabAreaPopulatedWithFiguresTab()) {
		var tabName =3D "Data"; // important - the tabName maps to the XSL =
file
		setupOnClickEventsOnFilmstripImages(tabName);
		getAndSetFigureDetails(tabName);
	}
	if (isPrimaryTabAreaPopulatedWithReferencesSubTab()) {
		setUpTableSortingForReferences();
		setUpContextsForAllReferences();
		if (isPrimaryTabAreaPopulatedWithReferencesMainTab()) {
			creatYearGraph();
			createAuthorFilter();
		}
	}
	if(isPrimaryTabAreaPopulatedWithIntroductionTab()) {
		setUpPopUpReferencesOnTextSubTab();
		setSwitchingOfSubTabs();
	}
=09
	if(isPrimaryTabAreaPopulatedWithResultsTab()){
		var tabName =3D $("ul.backtabs li.active a").attr("href");
		tabName =3D tabName.replace(/^.*#/, '');
		setUpPopUpReferencesOnTextSubTab();
		setSwitchingOfSubTabs();
		setUpZoomImageOnResultsTab(tabName);
	}
=09
	if(isPrimaryTabAreaPopulatedWithRelatedInfoTab()) {
		setSwitchingOfSubTabs();
	}
=09
	if(isPrimaryTabAreaPopulatedWithDiscussionTab()) {
		setUpPopUpReferencesOnTextSubTab();
		setSwitchingOfSubTabs();
		setUpFiguresLinkingOnDiscussionAndExpProceduresTab();
		setAnchorStylesOnDiscussionAndExpProceduresTab();
	}
	if(isPrimaryTabAreaPopulatedWithExperimentalProceduresTab()) {
		setUpPopUpReferencesOnTextSubTab();
		setSwitchingOfSubTabs();
		setUpFiguresLinkingOnDiscussionAndExpProceduresTab();
		setAnchorStylesOnDiscussionAndExpProceduresTab();
	}
=09
	if(isPrimaryTabAreaPopulatedWithSummaryTab()) {
		setUpPopUpReferencesOnTextSubTab();
	}
=09
	miscellaneousJSCallsToMakeAdjustmentsToUI();
}


function miscellaneousJSCallsToMakeAdjustmentsToUI() {
	// Summary/Abstract Tab - Render Article Highlights Coming With Special =
Character Appear as List Items.
	if( $('ul#highlights').length > 0 ) {
		var highlightSectionHtml =3D $('ul#highlights').html();
		var highlightHeadingHtml =3D $('ul#highlights =
li#highlightsHeading').html();
		var highlights =3D $('ul#highlights').html().split('>' + =
highlightHeadingHtml + getListTagBasedOnBrowser())[1];
		//If Highlights already contain List Tags then no alteration Required!
		if ( highlights.match(getListTagBasedOnBrowser()) =3D=3D null ) {
			var specialCharacter =3D "";
			//If the special character has been converted to a glyph then remove =
the complete  element
			if( highlights.substring(0,4) =3D=3D getImageTagBasedOnBrowser() ) {
				specialCharacter =3D highlights.substring(0, highlights.indexOf('>') =
+ 1);
			} else {
				specialCharacter =3D highlights.substring(0,1);
			}
			var highlightsList =3D highlights.split(specialCharacter);
			var createHighlights =3D "";
			for( var i=3D1; i< highlightsList.length; i++) {
				createHighlights =3D createHighlights + "" + highlightsList[i] + =
"";
			}
			$('ul#highlights').html(highlightSectionHtml.replace(highlights, =
createHighlights));
		}
	}
	//If abstract page and the Tab Name in Url is inapporipriate - Show =
Summar Tab as default Tab
	if($('ul#aotftabs').length > 0) {
		if($('ul#aotftabs li.active').length < 1) {
			$('ul#aotftabs li:first').addClass('active');
		}
	}
}

function getImageTagBasedOnBrowser() {
	if(document.all) {
		return '';
	} else {
		return '';
	}
}


// update the primary area of the tab - for some tabs this is the only =
update made
function updatePrimaryTabArea(str) {
	$("#load").html(str);
	$("#ajaxanim").hide();
}

function getAndSetFigureDetails(tabName){
	var figId =3D $("#p1 li:eq(0)").attr('fig');
	switchFiguresInTab(figId, $("#aotf_pii").html(), tabName);
	$("#p1 li:eq(0)").addClass("active");
}

function switchFiguresInTab(figureId, articlePii, tabName) {
    AOTFDwrController.fetchFigureContentForTab(figureId, articlePii, =
tabName, updateFigureDetails);
}

function switchZoomFiguresInResultsTab(refid, articlePii, tabName) {
    AOTFDwrController.fetchFigureContentForTab(refid, articlePii, =
tabName, updateResultsFigureDetails);
}

function updateFigureDetails(str) {
	$("#figdetail").html(str);
	$("#figajaxanim").hide();
	setupCaptionAndContextInFiguresTabToggle();
	setUpPopUpReferencesOnTextSubTab();
}

function updateResultsFigureDetails(str) {
	$("#zoomFigureChangeSource").html(str);
	$("#figajaxanim").hide();
	setUpPopUpReferencesOnTextSubTab();
	setUpClickForResultsZoomInCaption();
}

function isPrimaryTabAreaPopulatedWithFiguresTab() {
	return $("div#figuresTabContent").length > 0;
}

function isPrimaryTabAreaPopulatedWithReferencesSubTab() {
	return $("#refs_table").length > 0;
}

function isPrimaryTabAreaPopulatedWithReferencesMainTab() {
	return $("div#references").length > 0;
}

function isPrimaryTabAreaPopulatedWithIntroductionTab() {
	return $("div#introduction").length > 0;
}

function isPrimaryTabAreaPopulatedWithResultsTab() {
	return $("div#results").length > 0;
}

function isPrimaryTabAreaPopulatedWithRelatedInfoTab() {
	return $("div#relatedinfo").length > 0;
}

function isPrimaryTabAreaPopulatedWithDiscussionTab() {
	return $("div#discussion").length > 0;
}

function isPrimaryTabAreaPopulatedWithExperimentalProceduresTab() {
	return $("div#experimental").length > 0;
}

function isPrimaryTabAreaPopulatedWithSummaryTab() {
	return $("div#summary").length > 0;
}

function setUpZoomImageOnResultsTab(tabName) {
	getZoomWidths();
	$("#zoomresults li a.zoom, #zoomcaptionscroll =
a.zoom").click(function(){
		$("#figajaxanim").show();
		$("#popup_ref").hide();
		var refid=3D$(this).attr("ref");
		switchZoomFiguresInResultsTab(refid, $("#aotf_pii").html(), tabName);
		return false;=09
	});
}

function setUpClickForResultsZoomInCaption() {
	var tabName =3D $("ul.backtabs li.active a").attr("href");
	tabName =3D tabName.replace(/^.*#/, '');
	$("#zoomcaptionscroll a.zoom").click(function(){
		$("#figajaxanim").show();
		$("#popup_ref").hide();
		var refid=3D$(this).attr("ref");
		switchZoomFiguresInResultsTab(refid, $("#aotf_pii").html(), tabName);
		return false;=09
	});
}

function setUpTableSortingForReferences() {
//set up table sorting in ajaxed content.
	//check if the Tab has any references or not!
	if($("tbody#the_tbody tr").length > 0) {
		$(".tablesorter").tablesorter({=20
			sortList: [[0,0]], //default sort first column ascending
			headers: {=20
				// disable third column=20
				2: {=20
					sorter: false=20
				},=20
				3: {=20
					sorter: false=20
				}=20
			}=20
		});=20
	=09
	=09
		//mouseover effect for tables
		$(".tablesorter tbody tr").mouseover(function(){
		  	$(this).css("background-color","#CFCFCF");
		}).mouseout(function(){
		  	$(this).css("background-color","#EDEDED");
		});
		//set up Preview link
		$(".previewlink").click(function(){
			$(this).hide();
			($(this).parent()).parent().find(".preview_block").show();
			$(this).parent().find(".hidepreviewlink").show();		=09
			return false;
		});
		$(".hidepreviewlink").click(function(){
			$(this).hide();
			($(this).parent()).parent().find(".preview_block").hide();
			$(this).parent().find(".previewlink").show();		=09
			return false;
		});
	}
}

function setUpContextsForAllReferences() {
	$(document).ready(function() {
		var contextRefArray =3D $("div.preview_block");
		for(var count =3D 0; count";
	var hasContext =3D false;
	for( var tabNum =3D 0; tabNum < tabNames.length; tabNum++ )
	{
		var contextSentences =3D =
tabNames[tabNum].innerHTML.split(/\.\s|\.<\w*\/\w*>|\.\s*\n/);
		for ( var i =3D 0; i < contextSentences.length; i++ )
		{=09
			var bibRegex =3D new RegExp(bibId+"\\D");
			if(contextSentences[i].match(bibRegex) !=3D null) {
				var createContextStr =3D "";
				createContextStr =3D createContextStr + contextSentences[i] + ".";
				createContextStr =3D createContextStr + "";
				createContextStr =3D createContextStr + "";
				createContextStr =3D createContextStr + "View in Article";
				createContextStr =3D createContextStr + "";
				contextsForARef =3D contextsForARef + createContextStr;
				hasContext =3D true;
			}
		}
	}
	contextsForARef =3D contextsForARef + "";
	if (hasContext) {
		divContextBlock.innerHTML =3D contextsForARef;
		$(divContextBlock).find("a.tip:bib").css({
			'text-decoration': 'none',
			'color': '#000',
			'cursor': 'text'
		});
		$(divContextBlock).find("a[name=3D" + bibId + "]").css("font-weight", =
"bold");
	} else {
		$(divContextBlock).parent().find("li.previewlink").css("display", =
"none");
	}
}

function linkToArticleTab(linktotabname, contextDivId){
	var contextText =3D document.getElementById(contextDivId).innerHTML;
	//if the reference to article exists in same tab then just toggle tabs.
	if(location.href.split("#")[1].toLowerCase()  =3D=3D =
linktotabname.toLowerCase()){
		contextInArticleSelected =3D true;
		contextInArticleText =3D contextText;
		$('.intro-reftoggle').toggle();
		$('div#load ul.backtabs li:first').addClass('active');
		$('div#load ul.backtabs li:last').removeClass('active');
		insertJavascriptToAllElements();
	} //else open another tab via DWR
	else {
		var currenttabobjects =3D $("a[rel=3D'history']");
		for (var i=3D0; i containerleftedge) {
			$("#popup_ref").css( {"left": (containerleftedge - popupwidth) +"px" =
} );
		  }
		  var refname =3D $(this).attr("name");
		  refhtml =3D $("#"+refname).html();
		  $("#refx").html(refhtml.replace(getSpanWithNewLineBasedOnBrowser(), =
' '));
		  if ($('div#popup_ref div#popreflinks a.viewatlink').length > 0)
		  	{
				$("div#popup_ref div#popreflinks a.pubmedlink").css( =
{"border-right": "1px solid #BBBBBB" } );=20
				$("div#popup_ref div#popreflinks a.viewatlink").css( {"padding": =
"0pt 6px 0pt 6pt" } );
		  	}=09

		  $("#popup_ref").show();
		  e.stopPropagation();
		  return false;
	});
}

function getSpanWithNewLineBasedOnBrowser() {
	if(document.all) {
		return '
';
	} else {
		return '
';
	}
}

function setSwitchingOfSubTabs() {
	$(".tabContent ul.backtabs li").click(function(){
		$(".tabContent ul.backtabs li").removeClass("active");=20
		$(this).addClass("active");=20
		$("#popup_ref").hide();
		//$('.intro-reftoggle').toggle(); //show/hide caption or context text =
area TOGGLE not working
		$('.intro-reftoggle').hide();
		var thisid =3D $(this).attr('id');
		$("#"+thisid+"-div").show();
		return false;
	});
}

function setUpFiguresLinkingOnDiscussionAndExpProceduresTab() {
	$("ul.discussion li.textsection a.zoom, ul.experimental li.textsection =
a.zoom").click(function(){
		var refid=3D$(this).attr("ref");
		$("#popup_ref").hide();
        var thumbnailObj =3D document.getElementById('t' + refid);
        if(thumbnailObj) thumbnailObj.scrollIntoView(true);
		return false;=09
	});
}

function setAnchorStylesOnDiscussionAndExpProceduresTab() {
	$("ul.discussion li.textsection a, ul.experimental li.textsection =
a").each(function () {
		var refid=3D$(this).attr("ref");
        var thumbnailObj =3D document.getElementById('t' + refid);
		if(thumbnailObj) {
			var hyperContent =3D $(this).html();
			$(this).html("" + hyperContent + "");
			$(this).find("span").mouseover(function(){
				$(this).css("text-decoration","underline");
			}).mouseout(function(){
				$(this).css("text-decoration","none");
			});
		}
	});
}

function setUpPopUpReferencesOnTextSubTabForIE() {
	dctipobjs =3D $("#details_context .tip");
	dctipobjslen =3D dctipobjs.length;
	for (dctipidx=3D0; dctipidx containerleftedge) {
		$("#popup_ref").css( {"left": (containerleftedge - popupwidth) +"px" } =
);
	  }
	  var refname =3D $(event.srcElement).attr("name");		=20
	  refhtml =3D $("#"+refname).html();
	  $("#refx").html(refhtml.replace(getSpanWithNewLineBasedOnBrowser(), ' =
'));
	  if ($('div#popup_ref div#popreflinks a.viewatlink').length > 0)
		{
			$("div#popup_ref div#popreflinks a.pubmedlink").css( {"border-right": =
"1px solid #BBBBBB" } );=20
			$("div#popup_ref div#popreflinks a.viewatlink").css( {"padding": "0pt =
6px 0pt 6pt" } );
		}=09
	  $("#popup_ref").show();
	  return false;
}

------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/ajax/aotfDwrRendererController.js

if (dwr =3D=3D null) var dwr =3D {};
if (dwr.engine =3D=3D null) dwr.engine =3D {};
if (DWREngine =3D=3D null) var DWREngine =3D dwr.engine;

if (AOTFDwrController =3D=3D null) var AOTFDwrController =3D {};
AOTFDwrController._path =3D '/Cell/dwr';

AOTFDwrController.fetchTransformedTabContent =3D function(p0, p1, =
callback) {
  dwr.engine._execute(AOTFDwrController._path, 'AOTFDwrController', =
'fetchTransformedTabContent', p0, p1, callback);
}

AOTFDwrController.fetchFigureContentForTab =3D function(p0, p1, p2, =
callback) {
  dwr.engine._execute(AOTFDwrController._path, 'AOTFDwrController', =
'fetchFigureContentForTab', p0, p1, p2, callback);
}
AOTFDwrController.fetchTransformedTabContentForAbstractRequest =3D =
function(p0, p1, callback) {
	  dwr.engine._execute(AOTFDwrController._path, 'AOTFDwrController', =
'fetchTransformedTabContentForAbstractRequest', p0, p1, callback);
}



------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/ajax/fullTextDwrRenderer.js

var reflectTagsEnabled=3D1;

function toggleReflectUserPreference() {
	=
FullTextDwrController.toggleReflectUserPreference(getReflectUserPreferenc=
e);
}

function getReflectUserPreference(reflectUserPreference) {
	if(reflectUserPreference) {
		showReflect();
	} else {
		hideReflect();
	}
}

function showReflect() {
	reflectTagsEnabled=3D1;
	$(".reflect_protein").css({'background-color' : '#99FFFF'});
	$(".reflect_chemical").css({'background-color' : '#33FF00'});
	$(".reflect_ambiguous").css({'background-color' : '#FFFF00'});
	hideReflectUnwantedText();
	$("#toggleReflectOption").html("Click here to turn off Reflect.");=20
}

function hideReflect() {
	reflectTagsEnabled=3D0;
	$(".reflect_protein").css({'background-color' : 'transparent'});
	$(".reflect_chemical").css({'background-color' : 'transparent'});
	$(".reflect_ambiguous").css({'background-color' : 'transparent'});
	$("#toggleReflectOption").html("Click here to turn on Reflect.");
}

function hideReflectUnwantedText() {
	hideReflectHeaderIfExceptionThrown();
	hideReflectDiv("left_column");
	hideReflectDiv("right_column");
	hideReflectDiv("article_nav");
	hideReflectDiv("reflectfeedbackbutton");
}

function hideReflect() {
	reflectTagsEnabled=3D0;
	$(".reflect_protein").css({'background-color' : ''});
	$(".reflect_chemical").css({'background-color' : ''});
	$(".reflect_ambiguous").css({'background-color' : ''});
	$("#toggleReflectOption").html("Click here to turn on Reflect.");
}

function hideReflectUnwantedText() {
	hideReflectHeaderIfExceptionThrown();
	$(".reflect_protein").css({'background-color' : ''});
	$(".reflect_chemical").css({'background-color' : ''});
	$(".reflect_ambiguous").css({'background-color' : ''});
	$(".reflect_protein").css({'background-color' : '#99FFFF'});
	$(".reflect_chemical").css({'background-color' : '#33FF00'});
	$(".reflect_ambiguous").css({'background-color' : '#FFFF00'});
	hideReflectDiv("left_column");
	hideReflectDiv("right_column");
	hideReflectDiv("article_nav");
	hideReflectDiv("reflectfeedbackbutton");
}


function hideReflectDiv(divId) {
	$("#" + divId + " .reflect_protein").css({'background-color' : ''});
	$("#" + divId + " .reflect_chemical").css({'background-color' : ''});
	$("#" + divId + " .reflect_ambiguous").css({'background-color' : ''});
	if (document.all){
		hidereflectdivforie(divId);	=09
	}
}

function hidereflectdivforie(divId){
	proteinprobables =3D =
document.getElementById(divId).getElementsByTagName('SPAN');
	if (proteinprobables.length > 0){
		for (i=3D0; i<=3Dproteinprobables.length; i++){
			if (proteinprobables[i]){
				if (proteinprobables[i].className =3D=3D 'reflect_protein'){
					proteinprobables[i].style.backgroundColor =3D'';
				}
				if (proteinprobables[i].className =3D=3D 'reflect_chemical'){
					proteinprobables[i].style.backgroundColor =3D'';
				}
				if (proteinprobables[i].className =3D=3D 'reflect_ambiguous'){
					proteinprobables[i].style.backgroundColor =3D'';
				}
			}
		}
	}
}


function hideReflectHeaderIfExceptionThrown() {
	if($().find(".reflect_protein").length=3D=3D0 &&  =
$().find(".reflect_chemical").length =3D=3D0) {
		$("#reflectfeedbackbutton").css({'display' : 'none'});
	}
}

------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/ajax/fullTextDwrController.js

if (dwr =3D=3D null) var dwr =3D {};
if (dwr.engine =3D=3D null) dwr.engine =3D {};
if (DWREngine =3D=3D null) var DWREngine =3D dwr.engine;

if (FullTextDwrController =3D=3D null) var FullTextDwrController =3D {};
FullTextDwrController._path =3D '/Cell/dwr';

FullTextDwrController.toggleReflectUserPreference =3D function(callback) =
{
  dwr.engine._execute(FullTextDwrController._path, =
'FullTextDwrController', 'toggleReflectUserPreference', callback);
}

------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/cell/jquery-1.3.2.min.js

/*
 * jQuery JavaScript Library v1.3.2
 * http://jquery.com/
 *
 * Copyright (c) 2009 John Resig
 * Dual licensed under the MIT and GPL licenses.
 * http://docs.jquery.com/License
 *
 * Date: 2009-02-19 17:34:21 -0500 (Thu, 19 Feb 2009)
 * Revision: 6246
 */
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l=3Dthis,g,y=3Dl.jQuery,p=3Dl.$,o=3Dl.jQuery=3Dl.$=3Dfunction(E,F){return=
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H){M=3DL.getComputedStyle(J,null);N-=3DJ.scrollTop,I-=3DJ.scrollLeft;if(J=
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er&&!(o.offset.doesAddBorderForTableAndCells&&/^t(able|d|h)$/i.test(J.tag=
Name))){N+=3DparseInt(M.borderTopWidth,10)||0,I+=3DparseInt(M.borderLeftW=
idth,10)||0}F=3DG,G=3DJ.offsetParent}if(o.offset.subtractsBorderForOverfl=
owNotVisible&&M.overflow!=3D=3D"visible"){N+=3DparseInt(M.borderTopWidth,=
10)||0,I+=3DparseInt(M.borderLeftWidth,10)||0}E=3DM}if(E.position=3D=3D=3D=
"relative"||E.position=3D=3D=3D"static"){N+=3DK.offsetTop,I+=3DK.offsetLe=
ft}if(E.position=3D=3D=3D"fixed"){N+=3DMath.max(H.scrollTop,K.scrollTop),=
I+=3DMath.max(H.scrollLeft,K.scrollLeft)}return{top:N,left:I}}}o.offset=3D=
{initialize:function(){if(this.initialized){return}var =
L=3Ddocument.body,F=3Ddocument.createElement("div"),H,G,N,I,M,E,J=3DL.sty=
le.marginTop,K=3D'
';M=3D{position:"absolute",to=
p:0,left:0,margin:0,border:0,width:"1px",height:"1px",visibility:"hidden"=
};for(E in =
M){F.style[E]=3DM[E]}F.innerHTML=3DK;L.insertBefore(F,L.firstChild);H=3DF=
.firstChild,G=3DH.firstChild,I=3DH.nextSibling.firstChild.firstChild;this=
.doesNotAddBorder=3D(G.offsetTop!=3D=3D5);this.doesAddBorderForTableAndCe=
lls=3D(I.offsetTop=3D=3D=3D5);H.style.overflow=3D"hidden",H.style.positio=
n=3D"relative";this.subtractsBorderForOverflowNotVisible=3D(G.offsetTop=3D=
=3D=3D-5);L.style.marginTop=3D"1px";this.doesNotIncludeMarginInBodyOffset=
=3D(L.offsetTop=3D=3D=3D0);L.style.marginTop=3DJ;L.removeChild(F);this.in=
itialized=3Dtrue},bodyOffset:function(E){o.offset.initialized||o.offset.i=
nitialize();var =
G=3DE.offsetTop,F=3DE.offsetLeft;if(o.offset.doesNotIncludeMarginInBodyOf=
fset){G+=3DparseInt(o.curCSS(E,"marginTop",true),10)||0,F+=3DparseInt(o.c=
urCSS(E,"marginLeft",true),10)||0}return{top:G,left:F}}};o.fn.extend({pos=
ition:function(){var I=3D0,H=3D0,F;if(this[0]){var =
G=3Dthis.offsetParent(),J=3Dthis.offset(),E=3D/^body|html$/i.test(G[0].ta=
gName)?{top:0,left:0}:G.offset();J.top-=3Dj(this,"marginTop");J.left-=3Dj=
(this,"marginLeft");E.top+=3Dj(G,"borderTopWidth");E.left+=3Dj(G,"borderL=
eftWidth");F=3D{top:J.top-E.top,left:J.left-E.left}}return =
F},offsetParent:function(){var =
E=3Dthis[0].offsetParent||document.body;while(E&&(!/^body|html$/i.test(E.=
tagName)&&o.css(E,"position")=3D=3D"static")){E=3DE.offsetParent}return =
o(E)}});o.each(["Left","Top"],function(F,E){var =
G=3D"scroll"+E;o.fn[G]=3Dfunction(H){if(!this[0]){return null}return =
H!=3D=3Dg?this.each(function(){this=3D=3Dl||this=3D=3Ddocument?l.scrollTo=
(!F?H:o(l).scrollLeft(),F?H:o(l).scrollTop()):this[G]=3DH}):this[0]=3D=3D=
l||this[0]=3D=3Ddocument?self[F?"pageYOffset":"pageXOffset"]||o.boxModel&=
&document.documentElement[G]||document.body[G]:this[0][G]}});o.each(["Hei=
ght","Width"],function(I,G){var =
E=3DI?"Left":"Top",H=3DI?"Right":"Bottom",F=3DG.toLowerCase();o.fn["inner=
"+G]=3Dfunction(){return =
this[0]?o.css(this[0],F,false,"padding"):null};o.fn["outer"+G]=3Dfunction=
(K){return this[0]?o.css(this[0],F,false,K?"margin":"border"):null};var =
J=3DG.toLowerCase();o.fn[J]=3Dfunction(K){return =
this[0]=3D=3Dl?document.compatMode=3D=3D"CSS1Compat"&&document.documentEl=
ement["client"+G]||document.body["client"+G]:this[0]=3D=3Ddocument?Math.m=
ax(document.documentElement["client"+G],document.body["scroll"+G],documen=
t.documentElement["scroll"+G],document.body["offset"+G],document.document=
Element["offset"+G]):K=3D=3D=3Dg?(this.length?o.css(this[0],J):null):this=
.css(J,typeof K=3D=3D=3D"string"?K:K+"px")}})})();
------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/cell/loginValidator.js

function validateLogin() {
	if(document.getElementById("userName").value=3D=3D"" || =
document.getElementById("password").value=3D=3D"") {
		document.getElementById("loginError").innerHTML =3D "Please enter a =
valid User Name and Password.";
		return false;
	}
	return true;
}

function validateAlertsLogin() {
	if(document.eaLogin.userName.value=3D=3D"" || =
document.eaLogin.password.value=3D=3D"") {
		document.getElementById("alertsLoginError").innerHTML =3D "Please =
enter a valid User Name and Password.";
		return false;
	}
	return true;
}

function validateLoginForDiagnosticPage() {
	if(document.getElementById("userName").value=3D=3D"" || =
document.getElementById("password").value=3D=3D"") {
		return false;
	}
	return true;
}

function validateRenewOnlineLogin() {
	if(document.renewLoginForm.userName.value=3D=3D"" || =
document.renewLoginForm.password.value=3D=3D"") {
		document.getElementById("renewOnlineloginError").innerHTML =3D "Please =
enter a valid User Name and Password.";
		document.getElementById("renewOnlineloginError").className =3D "alert =
errormsg";
		return false;
	}
	return true;
}

------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/cell/header.js

/*New Login form*/

$(document).ready(function(){
	$(".expander a").hover(
			function(){
				var tabId =3D $(this).attr("id");
				document.getElementById(tabId+"SubTab").style.display =3D 'block';
				/*$("#"+tabId+"SubTab").show();*/
			},
			function(){
				var tabId =3D $(this).attr("id");
				$("#"+tabId+"SubTab").hide();
			});
	$(".globalsubtab").hover(
			function(){
				$(this).show();
			},
			function(){
				$(this).hide();
			});

	$('#login_link').click(
		function(){
		=
if(document.getElementById('floating_login_form').style.right=3D=3D'20pt'=
){	=09
			=
document.getElementById('floating_login_form').style.right=3D'9999pt';
		} else {
			document.getElementById('floating_login_form').style.right=3D'20pt';
			document.forms.LoginForm.userName.focus();
		}
	=09
		return false;
	});
	checkForLoginError();
	checkForMissingTabs();

}); //ready

function checkForLoginError() {
	if (document.getElementById('login_link')) {
		if (document.getElementById('loginError').innerHTML !=3D '') {
			document.getElementById('floating_login_form').style.right =3D '0pt';
		}
	}
}

function checkForMissingTabs(){
=09
	if($('#newArticles').length =3D=3D 0){
		$("#forAuthorsSubTab").css("left","185px");
		$("#journalInfoSubTab").css("left","290px");
		$("#changeJournalSubTab").css("left","560px");
		$("#CellPressSubTab").css("left","680px");

		if($('#journalInfoSubTab').length =3D=3D 0){
			$("#changeJournalSubTab").css("left","420px");
			$("#CellPressSubTab").css("left","540px");
		}

		if($('#forAuthorsSubTab').length =3D=3D 0){
			$("#journalInfoSubTab").css("left","195px");
			$("#changeJournalSubTab").css("left","460px");
			$("#CellPressSubTab").css("left","585px");
		}=09
	=09
		if(($('#journalInfoSubTab').length =3D=3D 0) && =
($('#forAuthorsSubTab').length =3D=3D 0)){
			$("#changeJournalSubTab").css("left","320px");
			$("#CellPressSubTab").css("left","445px");
		}
	} else {
	=09
		if($('#journalInfoSubTab').length =3D=3D 0){
			$("#changeJournalSubTab").css("left","505px");
			$("#CellPressSubTab").css("left","630px");
		}

		if($('#forAuthorsSubTab').length =3D=3D 0){
			$("#journalInfoSubTab").css("left","285px");
			$("#changeJournalSubTab").css("left","555px");
			$("#CellPressSubTab").css("left","675px");

			if($('#journalInfoSubTab').length =3D=3D 0){
				$("#changeJournalSubTab").css("left","412px");
				$("#CellPressSubTab").css("left","535px");
			}
		}
	}
}
------=_NextPart_000_0000_01CAFDBC.7EA03CF0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.cell.com/js/cell/utils.js

function LTrim( value ) {
=09
	var re =3D /\s*((\S+\s*)*)/;
	return value.replace(re, "$1");
=09
}

// Removes ending whitespaces
function RTrim( value ) {
	var re =3D /((\s*\S+)*)\s*/;
	return value.replace(re, "$1");
=09
}

// Removes leading and ending whitespaces
function trim( value ) {
	return LTrim(RTrim(value));
}


function validateInputField(fieldId, minLength, errorDivId, =
errorMessage) {
	var trimmedFieldValue =3D new =
String(trim(document.getElementById(fieldId).value));
	if(trimmedFieldValue.length < minLength) {
	=09
		setErrorMessage(fieldId,errorMessage);
		return false;
	} else {
		if(document.getElementById(errorDivId).innerHTML !=3D "")
			removeErrorMessage(fieldId);
		return true;
	}
}

function validateInputFieldForSimpleForms(fieldId, minLength, =
errorDivId, errorMessage) {
	var trimmedFieldValue =3D new =
String(trim(document.getElementById(fieldId).value));
	if(trimmedFieldValue.length < minLength) {
		document.getElementById(errorDivId).className =3D "alert errormsg";
		document.getElementById(errorDivId).innerHTML =3D errorMessage;
		document.getElementById(errorDivId).style.display =3D "block";
		return false;
	} else {
	=09
		if(document.getElementById(errorDivId).innerHTML !=3D "")
		{
			document.getElementById(errorDivId).innerHTML =3D "";
			document.getElementById(errorDivId).className =3D "";
			document.getElementById(errorDivId).style.display =3D "none";=09
		}
		return true;
	}
}

function validateActivateInputField(fieldId, minLength, errorDivId, =
errorMessage) {
	var trimmedFieldValue =3D new =
String(trim(document.getElementById(fieldId).value));
	var message =3D document.getElementById(errorDivId).innerHTML;
	if(trimmedFieldValue.length < minLength) {=09
		document.getElementById(errorDivId).innerHTML =3D errorMessage;
		document.getElementById(errorDivId).className =3D "alert errormsg =
alertwide";
		document.getElementById(errorDivId).style.display =3D "block";
		return false;
	}else if(!(message =3D=3D errorMessage)){
		return true;
	}=20
	else {=09
		document.getElementById(errorDivId).innerHTML =3D "";
		document.getElementById(errorDivId).className =3D "";
		document.getElementById(errorDivId).style.display =3D "none";	=09
		return true;
	}
}

function validateActivateInputFieldForSimpleForms(fieldId, minLength, =
errorDivId, errorMessage) {
	var trimmedFieldValue =3D new =
String(trim(document.getElementById(fieldId).value));
	var message =3D document.getElementById(errorDivId).innerHTML;
	if(trimmedFieldValue.length < minLength) {=09
		document.getElementById(errorDivId).innerHTML =3D errorMessage;
		document.getElementById(errorDivId).className =3D "alert errormsg";
		document.getElementById(errorDivId).style.display =3D "block";
		return false;
	}else if(!(message =3D=3D errorMessage)){
		return true;
	}=20
	else {=09
		document.getElementById(errorDivId).innerHTML =3D "";
		document.getElementById(errorDivId).className =3D "";
		document.getElementById(errorDivId).style.display =3D "none";=09
		return true;
	}
}
function validateCustomerNumberInputField(fieldId, minLength, =
errorDivId, errorMessage) {
	var trimmedFieldValue =3D new =
String(trim(document.getElementById(fieldId).value));
	if(trimmedFieldValue.length < minLength) {
=09
		document.getElementById(errorDivId).innerHTML =3D errorMessage;
		return false;
	}=20
	else {
			if(document.getElementById(errorDivId).innerHTML !=3D "")
				document.getElementById(errorDivId).innerHTML =3D "";
			return true;
		}
		return true;
}

function validateSelectField(fieldId, errorDivId, errorMessage) {
	if(document.getElementById(fieldId).selectedIndex=3D=3D0) {
		setErrorMessage(fieldId,errorMessage);
		return false;
	} else {
		removeErrorMessage(fieldId);
		return true;
	}
}

function validateEmailField(emailAddressDivId, errorDivId, errorMessage) =
{
	var trimmedFieldValue =3D new =
String(trim(document.getElementById(emailAddressDivId).value));
	var emailReg =3D =
/^([a-zA-Z0-9_\.\-])+\@(([a-zA-Z0-9\-])+\.)+([a-zA-Z0-9]{2,4})+$/;
	var regex =3D new RegExp(emailReg);
	var valid =3D regex.test(trimmedFieldValue);
	if(valid) {
		if(document.getElementById(errorDivId).innerHTML !=3D "")
			removeErrorMessage(emailAddressDivId,errorMessage);
	} else {
		setErrorMessage(emailAddressDivId,errorMessage);
	}
	return valid;
}

function validateEmailFieldForSimpleForms(emailAddressDivId, errorDivId, =
errorMessage) {
	var trimmedFieldValue =3D new =
String(trim(document.getElementById(emailAddressDivId).value));
	var emailReg =3D =
/^([a-zA-Z0-9_\.\-])+\@(([a-zA-Z0-9\-])+\.)+([a-zA-Z0-9]{2,4})+$/;
	var regex =3D new RegExp(emailReg);
	var valid =3D regex.test(trimmedFieldValue);

	if(valid) {
			if(document.getElementById(errorDivId).innerHTML !=3D ""){
					document.getElementById(errorDivId).innerHTML =3D "";
					document.getElementById(errorDivId).className =3D "";
					document.getElementById(errorDivId).style.display =3D "none";
			}
		} else {
			document.getElementById(errorDivId).innerHTML =3D errorMessage;		=09
			document.getElementById(errorDivId).className =3D "alert errormsg";
			document.getElementById(errorDivId).style.display =3D "block";
		}
	return valid;
}

function validateUserName() {
	return validateInputField('registrationUsername', 6, =
'registrationUsername_error', 'Please enter a User Name that is at least =
6 characters long.');
}

function validatePassword() {
	return validateInputField('registrationPassword', 6, =
'registrationPassword_error', 'Please enter a Password that is at least =
6 characters long.');
}

function validateConfirmPassword() {
	if(document.getElementById('registrationPassword').value !=3D =
document.getElementById('confirmPassword').value) {
		document.getElementById('confirmPassword_error').innerHTML =3D "Please =
ensure the Passwords match.";
		return false;
	} else {
		document.getElementById('confirmPassword_error').innerHTML =3D "";
		return true;
	}=09
}

function doCitationDownload()
{
	var url =3D "about:blank";
    var windowOptions =3D =
"width=3D680,height=3D480,innerWidth=3D680,innerHeight=3D480,top=3D0,left=
=3D50,screenX=3D0,screenY=3D0,scrollbars=3Dyes,resizable=3Dyes,toolbar=3D=
yes,status=3Dyes";   =09
	//var windowOptions =3D =
"width=3D700,height=3D500,left=3D150,top=3D150,screenX=3D150,screenY=3D15=
0,resizable=3Dyes,scrollbars=3Dno";
	var form =3D document.forms["citationExportForm"];
	var popWin =3D window.open(url,"ExportCitations",windowOptions);
    popWin.focus();
    form.target =3D "ExportCitations";
    form.submit();
	return true;
}

function getElementsByClassName(strClass, strTag, objContElm) {
  strTag =3D strTag || "*";
  objContElm =3D objContElm || document;
  var objColl =3D objContElm.getElementsByTagName(strTag);
  if (!objColl.length &&  strTag =3D=3D "*" &&  objContElm.all) objColl =
=3D objContElm.all;
  var arr =3D new Array();
  var delim =3D strClass.indexOf('|') !=3D -1  ? '|' : ' ';
  var arrClass =3D strClass.split(delim);
  for (var i =3D 0, j =3D objColl.length; i < j; i++) {
    var arrObjClass =3D objColl[i].className.split(' ');
    if (delim =3D=3D ' ' && arrClass.length > arrObjClass.length) =
continue;
    var c =3D 0;
    comparisonLoop:
    for (var k =3D 0, l =3D arrObjClass.length; k < l; k++) {
      for (var m =3D 0, n =3D arrClass.length; m < n; m++) {
        if (arrClass[m] =3D=3D arrObjClass[k]) c++;
        if (( delim =3D=3D '|' && c =3D=3D 1) || (delim =3D=3D ' ' && c =
=3D=3D arrClass.length)) {
          arr.push(objColl[i]);
          break comparisonLoop;
        }
      }
    }
  }
  return arr;
}

function onLoadOfFullText(cont)
{
// To cover IE 5.0's lack of the push method
Array.prototype.push =3D function(value) {
  this[this.length] =3D value;
}
//var cont =3D document.getElementById('main_content');

if(!is_safari){
var crosslinks =3D getElementsByClassName('ja50-ce-cross-ref','a', =
cont);
for(i=3D0;i]*>[\s\S]+<\/a>/ig,"");
			newdiv.innerHTML =3D reftest;
			this.appendChild(newdiv);
				}
			}

	crosslinks[i].onmouseout=3Dfunction(){
		this.style.position =3D "static";	=09
		myname =3D this.getAttribute('name');
		if(myname.indexOf('bib') !=3D-1){
			refid =3D myname.replace('back-','');
		    var oNodeToRemove =3D document.getElementById(refid+'box');
		    if(oNodeToRemove)
		    oNodeToRemove.parentNode.removeChild(oNodeToRemove);
		}
	}
	}
}
}
function refresh()
{
	var sURL =3D unescape(window.location.pathname);
    window.location.href =3D sURL;
}
function reloadWithParam(paramName , paramValue)
{
	var sURL =3D unescape(window.location.pathname);
	sURL =3D sURL + '?' +paramName +'=3D' + paramValue;
    window.location.href =3D sURL;
}

function archivelist() {

       // if the user clicks on an anchor link within a top-level list =
item in ul#article_outline_list_archive,
       // make the child UL be class 'open'=20
       archivepanel =3D =
document.getElementById('article_outline_list_archive');
       mylinks =3D archivepanel.getElementsByTagName('A');
       for (var i=3D0; i=3D 4);  // changed to =
is_minor for
                                                // consistency - dmr, =
011001
    var is_navonly      =3D (is_nav && ((agt.indexOf(";nav") !=3D -1) ||
                          (agt.indexOf("; nav") !=3D -1)) );

    var is_nav6   =3D (is_nav && is_major=3D=3D6);    // new 010118 mhp
    var is_nav6up =3D (is_nav && is_minor >=3D 6); // new 010118 mhp

    var is_nav5   =3D (is_nav && is_major =3D=3D 5 && !is_nav6); // =
checked for ns6
    var is_nav5up =3D (is_nav && is_minor >=3D 5);

    var is_nav7   =3D (is_nav && is_major =3D=3D 7);
    var is_nav7up =3D (is_nav && is_minor >=3D 7);

    var is_nav8   =3D (is_nav && is_major =3D=3D 8);
    var is_nav8up =3D (is_nav && is_minor >=3D 8);

    var is_ie   =3D ((iePos!=3D-1) && (!is_opera) && (!is_khtml));
    var is_ie3  =3D (is_ie && (is_major < 4));

    var is_ie4   =3D (is_ie && is_major =3D=3D 4);
    var is_ie4up =3D (is_ie && is_minor >=3D 4);
    var is_ie5   =3D (is_ie && is_major =3D=3D 5);
    var is_ie5up =3D (is_ie && is_minor >=3D 5);
   =20
    var is_ie5_5  =3D (is_ie && (agt.indexOf("msie 5.5") !=3D-1)); // =
020128 new - abk
    var is_ie5_5up =3D(is_ie && is_minor >=3D 5.5);                // =
020128 new - abk
=09
    var is_ie6   =3D (is_ie && is_major =3D=3D 6);
    var is_ie6up =3D (is_ie && is_minor >=3D 6);

    var is_ie7   =3D (is_ie && is_major =3D=3D 7);
    var is_ie7up =3D (is_ie && is_minor >=3D 7);

// KNOWN BUG: On AOL4, returns false if IE3 is embedded browser
    // or if this is the first browser window opened.  Thus the
    // variables is_aol, is_aol3, and is_aol4 aren't 100% reliable.

    var is_aol   =3D (agt.indexOf("aol") !=3D -1);
    var is_aol3  =3D (is_aol && is_ie3);
    var is_aol4  =3D (is_aol && is_ie4);
    var is_aol5  =3D (agt.indexOf("aol 5") !=3D -1);
    var is_aol6  =3D (agt.indexOf("aol 6") !=3D -1);
    var is_aol7  =3D ((agt.indexOf("aol 7")!=3D-1) || =
(agt.indexOf("aol7")!=3D-1));
    var is_aol8  =3D ((agt.indexOf("aol 8")!=3D-1) || =
(agt.indexOf("aol8")!=3D-1));

    var is_webtv =3D (agt.indexOf("webtv") !=3D -1);
   =20
    // new 020128 - abk
   =20
    var is_TVNavigator =3D ((agt.indexOf("navio") !=3D -1) || =
(agt.indexOf("navio_aoltv") !=3D -1));=20
    var is_AOLTV =3D is_TVNavigator;

    var is_hotjava =3D (agt.indexOf("hotjava") !=3D -1);
    var is_hotjava3 =3D (is_hotjava && (is_major =3D=3D 3));
    var is_hotjava3up =3D (is_hotjava && (is_major >=3D 3));

    // end new
=09
    // *** JAVASCRIPT VERSION CHECK ***
    // Useful to workaround Nav3 bug in which Nav3
    // loads