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Bromelain

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Cancer Research


Desser L, Holomanova D, Zavadova E, Pavelka K, Mohr T, Herbacek I
Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood
Cancer Chemother Pharmacol 2001 Jul;47 Suppl:S10-5 

Gerard G.
Anticancer treatment and bromelains
Agressologie 1972;13(4):261-74 

Maurer HR
Bromelain: biochemistry, pharmacology and medical use
Cell Mol Life Sci. 2001 Aug;58(9):1234-45 

Taussig SJ, Batkin S
Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update
J Ethnopharmacol 1988 Feb-Mar;22(2):191-203 

Taussig SJ, Szekerczes J, Batkin S
Inhibition of tumour growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus)
Planta Med 1985 Dec;(6):538-9 


Vellini M, Desideri D, Milanese A, Omini C, Daffonchio L, Hernandez A, Brunelli G
Possible involvement of eicosanoids in the pharmacological action of bromelain
Arzneimittelforschung 1986;36(1):110-2 


Gliomas


Fujita M, Kohanbash G, Fellows-Mayle W, Hamilton RL, Komohara Y, Decker SA, Ohlfest JR, Okada H.
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.
Cancer Res. 2011 Feb 15. [Epub ahead of print]
  Abstract |   Related articles

Sharma V, Dixit D, Ghosh S, Sen E.
COX-2 regulates the proliferation of glioma stem like cells.
Neurochem Int. 2011 Jul 7. [Epub ahead of print]
  Abstract |   Related articles

Temel SG, Kahveci Z
Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma
J Mol Histol. 2010 Jan 6;. [Epub ahead of print]
  Abstract

Tysnes BB, Maurer HR, Porwol T, Probst B, Bjerkvig R, Hoover F
Bromelain reversibly inhibits invasive properties of glioma cells
Neoplasia 2001 Nov-Dec;3(6):469-79

  Abstract |   Reprint |   Related articles

Xu K, Gao H, Shu HK.
Celecoxib can induce vascular endothelial growth factor expression and tumor angiogenesis.
Mol Cancer Ther. 2011 Jan;10(1):138-47.
  Abstract |   Related articles


Medulloblastoma


Baryawno N, Sveinbjörnsson B, Eksborg S, Orrego A, Segerström L, Oqvist CO, Holm S, Gustavsson B, Kågedal B, Kogner P, Johnsen JI.
Tumor-growthpromoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets
Neuro Oncol. 2008 Aug 20. [Epub ahead of print]
 Abstract


Monograph


Barrie Cassileth and K. Simon Yeung
Bromelain (Sulphydryl proteolytic enzyme, cysteine-proteinase)
11/07/2002 Memorial Sloar-Kettering Cancer Center (HTML Full Text)


Non-Neoplastic Diseases


Masson M.
Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice

Fortschr Med 1995 Jul 10;113(19):303-6 



Non-CNS Tumors


Beuth J, Ost B, Pakdaman A, Rethfeldt E, Bock PR, Hanisch J, Schneider B
Impact of complementary oral enzyme application on the postoperative treatment results of breast cancer patients--results of an epidemiological multicentre retrolective cohort study
Cancer Chemother Pharmacol 2001 Jul;47 Suppl:S45-54 

Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients
Oncol Rep 1999 Nov-Dec;6(6):1191-9 

Gujral MS, Patnaik PM, Kaul R, Parikh HK, Conradt C, Tamhankar CP, Daftary GV
Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers
Cancer Chemother Pharmacol 2001 Jul;47 Suppl:S23-8 

Kaul R, Mishra BK, Sutradar P, Choudhary V, Gujral MS
The role of Wobe-Mugos in reducing acute sequele of radiation in head and neck cancers--a clinical phase-III randomized trial
Indian J Cancer 1999 Jun-Dec;36(2-4):141-8 

Popiela T, Kulig J, Hanisch J, Bock PR
Influence of a complementary treatment with oral enzymes on patients with colorectal cancers--an epidemiological retrolective cohort study
Cancer Chemother Pharmacol 2001 Jul;47 Suppl:S55-63 


 

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