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Cancer Research


M. Llanos Casanova, Cristina Blázquez, Jesús Martínez-Palacio, Concepción Villanueva, M. Jesús Fernández-Aceñero, John W. Huffman, José L. Jorcano and Manuel Guzmán
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors 
J. Clin. Invest. January 1 2003, 111:43-50. ( PDF Full Text)

Manuel Guzmán
Cannabinoids: potential anticancer agents
Nature Reviews Cancer 3, 745-755 (October 2003) | doi:10.1038/nrc1188
 Abstract |  Reprint

Thomas W. Klein, Cathy Newton, Kellie Larsen, Lily Lu, Izabella Perkins, Liang Nong and Herman Friedman
The cannabinoid system and immune modulation 
Journal of Leukocyte Biology. 2003, October 1;74:486-496

Sarfaraz S, Adhami VM, Syed DN, Afaq F, Mukhtar H
Cannabinoids for cancer treatment: progress and promise
Cancer Res. 2008 Jan 15;68(2):339-42
 Abstract |  Reprint


Glioblastoma


Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, Lee J, Pakdel A, Allison J, Limbad C, Moore DH, Yount GL, Desprez PY, McAllister SD
Cannabidiol Enhances the Inhibitory Effects of {Delta}9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
Mol Cancer Ther. 2010 Jan 6;. [Epub ahead of print]
  Abstract

Torres S, Lorente M, Rodríguez-Fornés F, Hernández-Tiedra S, Salazar M, García-Taboada E, Barcia J, Guzmán M, Velasco G.
A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma.
Mol Cancer Ther. 2011 Jan;10(1):90-103.
  Abstract |   Related articles


Gliomas


Aguado T, Carracedo A, Julien B, Velasco G, Milman G, Mechoulam R, Alvarez L, Guzmán M, Galve-Roperh I
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
J Biol Chem. 2007 Mar 2;282(9):6854-62. Epub 2007 Jan 2
 Abstract |  Full Text |  Reprint

Cristina Blázquez, María Salazar, Arkaitz Carracedo, Mar Lorente, Ainara Egia, Luis González-Feria, Amador Haro, Guillermo Velasco and Manuel Guzmán
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
Cancer Res. 2008 Mar 15;68(6):1945-52
 Abstract |  Reprint

Blazquez C, Gonzalez-Feria L, Alvarez L, Haro A, Casanova ML, Guzman M
Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas
Cancer Res. 2004 Aug 15;64(16):5617-23
Cristina Blázquez, M. Llanos Casanova, Anna Planas, Teresa Gómez del Pulgar, Concepción Villanueva, María J. Fernández-Aceñero, Julián Aragonés, John W. Huffman, José L. Jorcano, and Manuel Guzmán 
Inhibition of tumor angiogenesis by cannabinoids
The FASEB Journal. 2003 March;17:529-531. Published online January 2, 2003. (
PDF Full Text)

Carracedo A, Geelen MJ, Diez M, Hanada K, Guzman M, Velasco G
Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids
Biochem J. 2004 Jun 1;380(Pt 2):435-40. 

Duntsch C, Divi MK, Jones T, Zhou Q, Krishnamurthy M, Boehm P, Wood G, Sills A, Ii BM
Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma
J Neurooncol. 2005 Nov 29;1-10 [Epub ahead of print]. 

Held-Feindt J, Dorner L, Sahan G, Mehdorn HM, Mentlein R.
Cannabinoid receptors in human astroglial tumors.
J Neurochem. 2006 Aug;98(3):886-93.
Abstract

Teresa Gómez del Pulgar, María L. de Ceballos, Manuel Guzmán, and Guillermo Velasco
Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
J. Biol. Chem., Vol. 277, CNO 39, 36527-36533, September 27, 2002. (PDF Full Text)

Stig O. P. Jacobsson , Thomas Wallin and Christopher J. Fowler 
Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors
J. Pharmacol. Exp. Ther., Vol. 299, CNO 3, 951-959, December 2001. (PDF Full Text) 

Paola Massi, Angelo Vaccani, Stefania Ceruti, Arianna Colombo, Maria P. Abbracchio, and Daniela Parolaro
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 838 - 845. 

Cristina Sánchez, María L. de Ceballos, Teresa Gómez del Pulgar, Daniel Rueda, César Corbacho, Guillermo Velasco, Ismael Galve-Roperh, John W. Huffman, Santiago Ramón y Cajal and Manuel Guzmán
Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor 
Cancer Research, 61, 5784-5789, August 1, 2001. (Full Text)

Velasco G, Galve-Roperh I, Sanchez C, Blazquez C, Guzman M
Hypothesis: cannabinoid therapy for the treatment of gliomas?
Neuropharmacology. 2004 Sep;47(3):315-23

Widmer M, Hanemann O, Zajicek J
High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells
J Neurosci Res. 2008 Jul 9; [Epub ahead of print]
  Abstract


Nonsteroid Anti-Infl Drugs


Rene Anikwue, John W. Huffman, Zachary L. Martin and Sandra P. Welch 
Decrease in Efficacy and Potency of Nonsteroidal Anti-Inflammatory Drugs by Chronic Δ9-Tetrahydrocannabinol Administration
J. Pharmacol. Exp. Ther., Vol. 303, CNO 1, 340-346, October 2002. (PDF Full Text) 


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